Product References
Protocol for PPP1R15A-inhibited mouse model establishment with subcutaneous B16F1 tumor and single-cell analysis.
STAR protocols
Wang R,Wang M,Pei S,Zhang Y,Guo S,Guo W,Wu Z,Wang H,Li Y,Zhu Y,Meng LH,Lang J,Jin G,Xiao Y,Hu L,Kong X
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Fri Dec 15 00:00:00 EST 2023
MCL-1 Inhibitor S63845 Distinctively Affects Intramedullary and Extramedullary Hematopoiesis.
Pharmaceutics
Zhang H,Li F,Yang M,Zhang W,He M,Xu H,Wang C,Zhang Y,Wang W,Gao Y,Du X,Li Y
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Tue Mar 28 00:00:00 EDT 2023
Peripheral Neutrophils-Derived Matrix Metallopeptidase-9 Induces Postoperative Cognitive Dysfunction in Aged Mice.
Frontiers in aging neuroscience
Huang L,Tian W,Chen X,Xu H,Dai W,Zhang Y,Wu X,Yu W,Tian J,Su D
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Mon Mar 14 00:00:00 EDT 2022
NK cells require immune checkpoint receptor LILRB4/gp49B to control neurotropic Zika virus infections in mice.
JCI insight
Lee HN,Manangeeswaran M,Lewkowicz AP,Engel K,Chowdhury M,Garige M,Eckhaus MA,Sourbier C,Ireland DD,Verthelyi D
12-5941-82 was used in Flow Cytometry to reveal LILRB4/gp49B as an important regulator of NK cell function during viral infections.
Tue Feb 08 00:00:00 EST 2022
NK cells require immune checkpoint receptor LILRB4/gp49B to control neurotropic Zika virus infections in mice.
JCI insight
Lee HN,Manangeeswaran M,Lewkowicz AP,Engel K,Chowdhury M,Garige M,Eckhaus MA,Sourbier C,Ireland DD,Verthelyi D
12-5941-82 was used in Flow Cytometry to reveal LILRB4/gp49B as an important regulator of NK cell function during viral infections.
Tue Feb 08 00:00:00 EST 2022
Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage.
Cell death & disease
Del Rio Oliva M,Basler M
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2022
Overriding impaired FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in murine diabetic wound.
eLife
Roy R,Zayas J,Singh SK,Delgado K,Wood SJ,Mohamed MF,Frausto DM,Albalawi YA,Price TP,Estupinian R,Giurini EF,Kuzel TM,Zloza A,Reiser J,Shafikhani SH
12-5941-82 was used in Flow cytometry/Cell sorting to posit that CCL3 may have therapeutic potential for the treatment of diabetic foot ulcers if it is applied topically after the surgical debridement process which is intended to reset chronic ulcers into acute fresh wounds.
Thu Feb 03 00:00:00 EST 2022
Mitotic SENP3 activation couples with cGAS signaling in tumor cells to stimulate anti-tumor immunity.
Cell death & disease
Hu G,Chen Y,Yang X,Wang Y,He J,Wang T,Fan Q,Deng L,Tu J,Tan H,Cheng J
12-5941-82 was used in Flow cytometry/Cell sorting to reveal that mitotic SENP3 activation in tumor cells can promote host anti-tumor immune response by coupling with cGAS signaling.
Fri Jul 22 00:00:00 EDT 2022
The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13.
Cellular & molecular immunology
Mulas F,Wang X,Song S,Nishanth G,Yi W,Brunn A,Larsen PK,Isermann B,Kalinke U,Barragan A,Naumann M,Deckert M,Schlüter D
12-5941 was used in Flow cytometry/Cell sorting to reveal that the deubiquitinase OTU domain, ubiquitin aldehyde binding 1 (OTUB1) is upregulated in DCs upon murine Toxoplasma gondii infection and lipopolysaccharide challenge.
Tue Jun 01 00:00:00 EDT 2021
The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude.
The Journal of experimental medicine
Li ZY,Morman RE,Hegermiller E,Sun M,Bartom ET,Maienschein-Cline M,Sigvardsson M,Kee BL
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Mon Jun 07 00:00:00 EDT 2021
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.
The Journal of experimental medicine
Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Mon Aug 02 00:00:00 EDT 2021
Exosomal lncRNA SNHG10 derived from colorectal cancer cells suppresses natural killer cell cytotoxicity by upregulating INHBC.
Cancer cell international
Huang Y,Luo Y,Ou W,Wang Y,Dong D,Peng X,Luo Y
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
Expression of CCRL2 Inhibits Tumor Growth by Concentrating Chemerin and Inhibiting Neoangiogenesis.
Cancers
Al Delbany D,Robert V,Dubois-Vedrenne I,Del Prete A,Vernimmen M,Radi A,Lefort A,Libert F,Wittamer V,Sozzani S,Parmentier M
12-5941-82 was used in Flow cytometry/Cell sorting to show that expression of CCRL2 by tumor cells enhances the local activity of chemerin, which inhibits neoangiogenesis and results in a reduction of tumor growth and progression.
Tue Oct 05 00:00:00 EDT 2021
Expression of CCRL2 Inhibits Tumor Growth by Concentrating Chemerin and Inhibiting Neoangiogenesis.
Cancers
Al Delbany D,Robert V,Dubois-Vedrenne I,Del Prete A,Vernimmen M,Radi A,Lefort A,Libert F,Wittamer V,Sozzani S,Parmentier M
12-5941-82 was used in Flow cytometry/Cell sorting to show that expression of CCRL2 by tumor cells enhances the local activity of chemerin, which inhibits neoangiogenesis and results in a reduction of tumor growth and progression.
Tue Oct 05 00:00:00 EDT 2021
Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.
EBioMedicine
Okada R,Furusawa A,Vermeer DW,Inagaki F,Wakiyama H,Kato T,Nagaya T,Choyke PL,Spanos WC,Allen CT,Kobayashi H
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
A novel miR1983-TLR7-IFNβ circuit licenses NK cells to kill glioma cells, and is under the control of galectin-1.
Oncoimmunology
Shah D,Comba A,Faisal SM,Kadiyala P,Baker GJ,Alghamri MS,Doherty R,Zamler D,Nuñez G,Castro MG,Lowenstein PR
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Mon Aug 02 00:00:00 EDT 2021
Physical restraint mouse models to assess immune responses under stress with or without habituation.
STAR protocols
Ding JX,Rudak PT,Inoue W,Haeryfar SMM
12-5941-82 was used in Flow Cytometry to provide protocols and guidelines in using three mouse restraint models, namely prolonged restraint stress, repeated restraint stress, and chronic variable stress, to examine immunological homeostasis/competence, or lack thereof, under stress with or without habituation.
Fri Dec 17 00:00:00 EST 2021
Sequencing, cloning, and antigen binding analysis of monoclonal antibodies isolated from single mouse B cells.
STAR protocols
Viant C,Escolano A,Chen ST,Nussenzweig MC
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Fri Jun 18 00:00:00 EDT 2021
The enrichment of neutrophil extracellular traps impair the placentas of systemic lupus erythematosus through accumulating decidual NK cells.
Scientific reports
Jiang M,Shen N,Zhou H,Wang Y,Lin S,Wu J,Di W
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Thu Mar 25 00:00:00 EDT 2021
Optimized protocol for immunophenotyping of melanoma and tumor-bearing skin from mouse.
STAR protocols
Krisna SS,Goncalves C,Gagnon N,Huang F,Plourde D,Miller WH,Fritz JH,Del Rincon SV
12-5941-82 was used in Flow cytometry/Cell sorting to determine a protocol for mouse skin isolation and immune cell isolation.
Fri Sep 17 00:00:00 EDT 2021
Mesenchymal stem cells attenuate liver fibrosis by targeting Ly6Chi/lo macrophages through activating the cytokine-paracrine and apoptotic pathways.
Cell death discovery
Li YH,Shen S,Shao T,Jin MT,Fan DD,Lin AF,Xiang LX,Shao JZ
12-5941-82 was used in Flow Cytometry to provide insights into the functional role of bone marrow-derived sesenchymal stem cell in alleviating liver fibrosis.
Mon Sep 13 00:00:00 EDT 2021
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist.
eLife
Glassman CR,Su L,Majri-Morrison SS,Winkelmann H,Mo F,Li P,Pérez-Cruz M,Ho PP,Koliesnik I,Nagy N,Hnizdilova T,Picton LK,Kovar M,Bollyky P,Steinman L,Meyer E,Piehler J,Leonard WJ,Garcia KC
12-5941 was used in Flow cytometry/Cell sorting to show that cytokine partial agonists can be used to calibrate intrinsic differences in response thresholds across responding cell types to narrow pleiotropic actions, which may be generalizable to other cytokine and growth factor systems.
Tue May 18 00:00:00 EDT 2021
Immune-evasive human islet-like organoids ameliorate diabetes.
Nature
Yoshihara E,O'Connor C,Gasser E,Wei Z,Oh TG,Tseng TW,Wang D,Cayabyab F,Dai Y,Yu RT,Liddle C,Atkins AR,Downes M,Evans RM
12-5941 was used in Flow cytometry/Cell sorting to generate human islet-like organoids (HILOs) from induced pluripotent stem cells and show that non-canonical WNT4 signalling drives the metabolic maturation necessary for robust ex vivo glucose-stimulated insulin secretion.
Thu Oct 01 00:00:00 EDT 2020
Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development.
Developmental cell
Dege C,Fegan KH,Creamer JP,Berrien-Elliott MM,Luff SA,Kim D,Wagner JA,Kingsley PD,McGrath KE,Fehniger TA,Palis J,Sturgeon CM
12-5941 was used in Flow cytometry/Cell sorting to identify an extra-embryonic origin of potently cytotoxic NK cells, suggesting that ontogenic origin is a relevant factor in designing hPSC-derived adoptive immunotherapies.
Mon Apr 20 00:00:00 EDT 2020
Critical role of OX40 in drug-induced acute liver injury.
British journal of pharmacology
Zhang C,Jin H,Wang Y,Li C,Zhao X,Li Y,Shi W,Tian Y,Xu H,Tian D,Liu K,Jia J,Sun G,Zhang D
12-5941-82 was used in Flow Cytometry to show that OX40 is a key molecule that promotes both pro-inflammatory macrophage and CD4+ T-cell function, exacerbating paracetamol-induced liver injury.
Wed Jul 01 00:00:00 EDT 2020
Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.
STAR protocols
Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Fri Jun 19 00:00:00 EDT 2020
Lipoteichoic Acid Is Involved in the Ability of the Immunobiotic Strain Lactobacillus plantarum CRL1506 to Modulate the Intestinal Antiviral Innate Immunity Triggered by TLR3 Activation.
Frontiers in immunology
Mizuno H,Arce L,Tomotsune K,Albarracin L,Funabashi R,Vera D,Islam MA,Vizoso-Pinto MG,Takahashi H,Sasaki Y,Kitazawa H,Villena J
12-5941 was used in Flow cytometry/Cell sorting to investigate how liopoteichoic acid contributes to the innate antiviral immune response in lactobilli.
Fri Mar 26 00:00:00 EDT 2021
Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state.
Nature communications
Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A
12-5941 was used in Flow cytometry/Cell sorting to study whether MP CD4+ T cells are functionally heterogeneous and, if so, what signals specify the differentiation of MP cell subpopulations under homeostatic conditions.
Mon Jul 06 00:00:00 EDT 2020
Lymphocyte-Specific Function of the DNA Polymerase Epsilon Subunit Pole3 Revealed by Neomorphic Alleles.
Cell reports
Siamishi I,Iwanami N,Clapes T,Trompouki E,O'Meara CP,Boehm T
12-5941 was used in Flow cytometry/Cell sorting to serve as a paradigm to understand the molecular basis of cell-type-specific non-replicative functions of the ubiquitous POLE complex.
Tue Jun 16 00:00:00 EDT 2020
The Innate Immune Response to Infection Induces Erythropoietin-Dependent Replenishment of the Dendritic Cell Compartment.
Frontiers in immunology
Einwächter H,Heiseke A,Schlitzer A,Gasteiger G,Adler H,Voehringer D,Manz MG,Ruzsics Z,Dölken L,Koszinowski UH,Sparwasser T,Reindl W,Jordan S
12-5941-82 was used in Flow Cytometry to investigate the molecular and cellular mechanisms of inflammation-induced dendritic cell generation.
Mon Apr 19 00:00:00 EDT 2021
Dendritic Cells and Myeloid Derived Suppressor Cells Fully Responsive to Stimulation via Toll-Like Receptor 4 Are Rapidly Induced from Bone-Marrow Cells by Granulocyte-Macrophage Colony-Stimulating Factor.
Vaccines
Kong YY,Wilson K,Apostolopoulos V,Plebanski M
12-5941 was used in Flow cytometry/Cell sorting to unveiled the role for the rapid initiation of productive immunity by GM-CSF.
Sat Sep 12 00:00:00 EDT 2020
Dendritic Cells and Myeloid Derived Suppressor Cells Fully Responsive to Stimulation via Toll-Like Receptor 4 Are Rapidly Induced from Bone-Marrow Cells by Granulocyte-Macrophage Colony-Stimulating Factor.
Vaccines
Kong YY,Wilson K,Apostolopoulos V,Plebanski M
12-5941 was used in Flow cytometry/Cell sorting to unveiled the role for the rapid initiation of productive immunity by GM-CSF.
Sat Sep 12 00:00:00 EDT 2020
Epigenetic Protection of Vertebrate Lymphoid Progenitor Cells by Dnmt1.
iScience
Iwanami N,Takeshita K,Lawir DF,Suetake I,Tajima S,Sikora K,Trancoso I,ÓMeara C,Siamishi I,Takahama Y,Furutani-Seiki M,Kondoh H,Yonezawa Y,Schorpp M,Boehm T
12-5941 was used in Flow cytometry/Cell sorting to identify new recessive dnmt1 alleles in medaka and zebrafish and, guided by the structures of mutant proteins, generated a recessive variant of mouse Dnmt1.
Fri Jul 24 00:00:00 EDT 2020
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.
Nature
Escolano A,Gristick HB,Abernathy ME,Merkenschlager J,Gautam R,Oliveira TY,Pai J,West AP,Barnes CO,Cohen AA,Wang H,Golijanin J,Yost D,Keeffe JR,Wang Z,Zhao P,Yao KH,Bauer J,Nogueira L,Gao H,Voll AV,Montefiori DC,Seaman MS,Gazumyan A,Silva M,McGuire AT,Stamatatos L,Irvine DJ,Wells L,Martin MA,Bjorkman PJ,Nussenzweig MC
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Sat Jun 01 00:00:00 EDT 2019
Immune synapses between mast cells and γδ T cells limit viral infection.
The Journal of clinical investigation
Mantri CK,St John AL
12-5941 was used in Flow cytometry/Cell sorting to show that immune synapse formation between MCs and γδ T cells is a novel mechanism to induce specific and protective immunity at sites of viral infection.
Fri Mar 01 00:00:00 EST 2019
Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development.
Cell systems
Zhou W,Yui MA,Williams BA,Yun J,Wold BJ,Cai L,Rothenberg EV
12-5941 was used in Flow cytometry/Cell sorting to imply that multilineage priming is integral to T cell specification.
Wed Oct 23 00:00:00 EDT 2019
Expression of Bioactive Chemerin by Keratinocytes Inhibits Late Stages of Tumor Development in a Chemical Model of Skin Carcinogenesis.
Frontiers in oncology
Dubois-Vedrenne I,De Henau O,Robert V,Langa F,Javary J,Al Delbany D,Vosters O,Angelats-Canals E,Vernimmen M,Luangsay S,Wittamer V,Parmentier M
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Mon Sep 28 00:00:00 EDT 2020
CD1d highly expressed on DCs reduces lung tumor burden by enhancing antitumor immunity.
Oncology reports
Li Y,Zhao C,Liu J,Lu Z,Lu M,Gu J,Liu R
12-5941 was used in Flow cytometry/Cell sorting to investigate whether CD1d expression on dendritic cells is capable of enhancing anti-tumour immunity, particularly T-cell related immunity.
Wed May 01 00:00:00 EDT 2019
Synergized regulation of NK cell education by NKG2A and specific Ly49 family members.
Nature communications
Zhang X,Feng J,Chen S,Yang H,Dong Z
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Fri Nov 01 00:00:00 EDT 2019
Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells.
JCI insight
Huang A,Shinde PV,Huang J,Senff T,Xu HC,Margotta C,Häussinger D,Willnow TE,Zhang J,Pandyra AA,Timm J,Weggen S,Lang KS,Lang PA
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Thu Sep 05 00:00:00 EDT 2019
Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia.
Nature communications
Hayashi Y,Goyama S,Liu X,Tamura M,Asada S,Tanaka Y,Fukuyama T,Wunderlich M,O'Brien E,Mizukawa B,Yamazaki S,Matsumoto A,Yamasaki S,Shibata T,Matsuda K,Sashida G,Takizawa H,Kitamura T
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Fri Oct 25 00:00:00 EDT 2019
ImmGen report: sexual dimorphism in the immune system transcriptome.
Nature communications
Gal-Oz ST,Maier B,Yoshida H,Seddu K,Elbaz N,Czysz C,Zuk O,Stranger BE,Ner-Gaon H,Shay T
12-5941 was used in Flow cytometry/Cell sorting to show transcriptional sexual dimorphism in macrophages.
Fri Sep 20 00:00:00 EDT 2019
The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis.
Frontiers in pharmacology
Hansel C,Erschfeld S,Baues M,Lammers T,Weiskirchen R,Trautwein C,Kroy DC,Drescher HK
12-5941 was used in Flow cytometry/Cell sorting to investigate the expression profile of inhibitory T cell receptors on CD4 and CD8 T cells in a mouse model of non-alcoholic steatohepatitis.
Wed Sep 30 00:00:00 EDT 2020
PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy.
The Journal of clinical investigation
Zamarin D,Ricca JM,Sadekova S,Oseledchyk A,Yu Y,Blumenschein WM,Wong J,Gigoux M,Merghoub T,Wolchok JD
Mon Apr 02 00:00:00 EDT 2018
Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.
Molecular therapy : the journal of the American Society of Gene Therapy
Ricca JM,Oseledchyk A,Walther T,Liu C,Mangarin L,Merghoub T,Wolchok JD,Zamarin D
Wed Apr 04 00:00:00 EDT 2018
Dysregulation of Kupffer Cells/Macrophages and Natural Killer T Cells in Steatohepatitis in LXRα Knockout Male Mice.
Endocrinology
Endo-Umeda K,Nakashima H,Umeda N,Seki S,Makishima M
Thu Mar 01 00:00:00 EST 2018
CD8+ T cells mediate the antitumor activity of frankincense and myrrh in hepatocellular carcinoma.
Journal of translational medicine
Xu C,Lu X,Liu W,Chen A,Meng G,Zhang H,Li B,Zhang Y,Wu J,Wei J
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Mon May 21 00:00:00 EDT 2018
Plasmodium co-infection protects against chikungunya virus-induced pathologies.
Nature communications
Teo TH,Lum FM,Ghaffar K,Chan YH,Amrun SN,Tan JJL,Lee CYP,Chua TK,Carissimo G,Lee WWL,Claser C,Rajarethinam R,Rénia L,Ng LFP
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Tue Sep 25 00:00:00 EDT 2018
Anti-JNK2 peptide-siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice.
International journal of nanomedicine
Pan H,Palekar RU,Hou KK,Bacon J,Yan H,Springer LE,Akk A,Yang L,Miller MJ,Pham CT,Schlesinger PH,Wickline SA
12-5941-82 was used in Flow cytometry/Cell sorting to devise a flexible platform for preventing the inflammatory drivers at their source to preserve plaque endothelium and mitigate procoagulant risk.
Mon Oct 29 00:00:00 EDT 2018
Inhibiting Glycogen Synthase Kinase 3 Reverses Obesity-Induced White Adipose Tissue Inflammation by Regulating Apoptosis Inhibitor of Macrophage/CD5L-Mediated Macrophage Migration.
Arteriosclerosis, thrombosis, and vascular biology
Wang L,Wang Y,Zhang C,Li J,Meng Y,Dou M,Noguchi CT,Di L
12-5941-82 was used in Flow cytometry/Cell sorting to examine the potential mechanism by which GSK3 in modulating obesity-induced visceral adipose tissue (VAT) inflammation.
Sat Sep 01 00:00:00 EDT 2018
STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis.
Nature medicine
Priego N,Zhu L,Monteiro C,Mulders M,Wasilewski D,Bindeman W,Doglio L,Martínez L,Martínez-Saez E,Ramón Y Cajal S,Megías D,Hernández-Encinas E,Blanco-Aparicio C,Martínez L,Zarzuela E,Muñoz J,Fustero-Torre C,Piñeiro-Yáñez E,Hernández-Laín A,Bertero L,Poli V,Sanchez-Martinez M,Menendez JA,Soffietti R,Bosch-Barrera J,Valiente M
12-5941-82 was used in flow cytometry experiments to describe that brain metastatic cells induce and maintain the co-option of a pro-metastatic program driven by STAT3 in a subpopulation of reactive astrocytes.
Sun Jul 01 00:00:00 EDT 2018
Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.
Immunity
Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,Donath MY
12-5941 was used in Flow cytometry/Cell sorting to provide evidence that an immunometabolic crosstalk between islet-derived IL-33, ILC2s, and myeloid cells fosters insulin secretion.
Tue Nov 21 00:00:00 EST 2017
Differentiation of human and murine induced pluripotent stem cells to microglia-like cells.
Nature neuroscience
Pandya H,Shen MJ,Ichikawa DM,Sedlock AB,Choi Y,Johnson KR,Kim G,Brown MA,Elkahloun AG,Maric D,Sweeney CL,Gossa S,Malech HL,McGavern DB,Park JK
12-5941 was used in Flow cytometry/Cell sorting to develop a technique for induced pluripotent stem cell-derived microglia-like cell differentiation.
Mon May 01 00:00:00 EDT 2017
A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells.
Leukemia
Cheadle EJ,Lipowska-Bhalla G,Dovedi SJ,Fagnano E,Klein C,Honeychurch J,Illidge TM
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Sat Jul 01 00:00:00 EDT 2017
Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy.
Proceedings of the National Academy of Sciences of the United States of America
Engler JB,Kursawe N,Solano ME,Patas K,Wehrmann S,Heckmann N,Lühder F,Reichardt HM,Arck PC,Gold SM,Friese MA
Tue Jan 10 00:00:00 EST 2017
Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway.
Cell death and differentiation
Shime H,Matsumoto M,Seya T
12-5941 was used in Flow cytometry/Cell sorting to study the response of CD11b+Ly6G+ granulocytic myeloid-derived suppressor cells to polyI:C in an EL4 tumour implant model.
Wed Mar 01 00:00:00 EST 2017
IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury.
Frontiers in neurology
Gao W,Li F,Zhou Z,Xu X,Wu Y,Zhou S,Yin D,Sun D,Xiong J,Jiang R,Zhang J
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis.
Nature communications
Krzywinska E,Kantari-Mimoun C,Kerdiles Y,Sobecki M,Isagawa T,Gotthardt D,Castells M,Haubold J,Millien C,Viel T,Tavitian B,Takeda N,Fandrey J,Vivier E,Sexl V,Stockmann C
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Fri Nov 17 00:00:00 EST 2017
LYG1 exerts antitumor function through promoting the activation, proliferation, and function of CD4+ T cells.
Oncoimmunology
Liu H,Zhang Y,Liu Z,Wang P,Mo X,Fu W,Liu W,Cheng Y,Han W
12-5941 was used in Flow cytometry/Cell sorting to reveal a tumor-inhibiting role for LYG1 through promoting the activation, proliferation, and function of CD4+T cells in antitumor immune responses, offering implications for novel tumor immunotherapy.
Tue Jan 12 00:00:00 EST 2021
Mononuclear Phagocytes Are Dispensable for Cardiac Remodeling in Established Pressure-Overload Heart Failure.
PloS one
Patel B,Ismahil MA,Hamid T,Bansal SS,Prabhu SD
12-5941 was used in Flow cytometry/Cell sorting to assess for alterations in MPs.
Thu Aug 10 00:00:00 EDT 2017
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Nature communications
Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP
12-5941 was used in Flow cytometry/Cell sorting to highlight that intratumoral immunomodulation with an oncolytic virus expressing a rationally selected ligand can be an effective strategy to drive systemic efficacy of immune checkpoint blockade.
Mon Feb 13 00:00:00 EST 2017
Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.
Cell
Wang A,Huen SC,Luan HH,Yu S,Zhang C,Gallezot JD,Booth CJ,Medzhitov R
12-5941 was used in an ELISA assay to analyse the effects of anorxia in mouse models wih viral and bacterial infections.
Thu Sep 08 00:00:00 EDT 2016
The breast tumor microenvironment alters the phenotype and function of natural killer cells.
Cellular & molecular immunology
Krneta T,Gillgrass A,Chew M,Ashkar AA
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Thu Sep 01 00:00:00 EDT 2016
Hypoxia-Inducible Factor-2α Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury.
Journal of the American Society of Nephrology : JASN
Zhang J,Han C,Dai H,Hou J,Dong Y,Cui X,Xu L,Zhang M,Xia Q
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
Platelets Guide Leukocytes to Their Sites of Extravasation.
PLoS biology
Zuchtriegel G,Uhl B,Puhr-Westerheide D,Pörnbacher M,Lauber K,Krombach F,Reichel CA
12-5941 was used in Flow cytometry/Cell sorting to uncover a platelet-directed, spatiotemporally organised, multicellular crosstalk that is essential for effective trafficking of leukocytes to the site of inflammation.
Sun May 01 00:00:00 EDT 2016
Dual Function of Ccr5 during Langat Virus Encephalitis: Reduction in Neutrophil-Mediated Central Nervous System Inflammation and Increase in T Cell-Mediated Viral Clearance.
Journal of immunology (Baltimore, Md. : 1950)
Michlmayr D,Bardina SV,Rodriguez CA,Pletnev AG,Lim JK
12-5941 was used in Flow cytometry/Cell sorting to study how Ccr5 is crucial in directing T cells toward the LGTV-infected brain, as well as in suppressing neutrophil-mediated inflammation within the CNS.
Wed Jun 01 00:00:00 EDT 2016
IFNγ is Required for Optimal Antibody-Mediated Immunity against Genital Chlamydia Infection.
Infection and immunity
Naglak EK,Morrison SG,Morrison RP
12-5941 was used in Flow cytometry/Cell sorting to examine the importance of interferon-gamma in antibody-mediated protection against chlamydia infection.
Tue Nov 01 00:00:00 EDT 2016
Protectin D1 reduces concanavalin A-induced liver injury by inhibiting NF-κB-mediated CX3CL1/CX3CR1 axis and NLR family, pyrin domain containing 3 inflammasome activation.
Molecular medicine reports
Ren J,Meng S,Yan B,Yu J,Liu J
12-5941 was used in Flow cytometry/Cell sorting to show that protectin D1 reduces concanavalin A-induced liver injury.
Fri Apr 01 00:00:00 EDT 2016
NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation.
Nature communications
Yang M,Chen S,Du J,He J,Wang Y,Li Z,Liu G,Peng W,Zeng X,Li D,Xu P,Guo W,Chang Z,Wang S,Tian Z,Dong Z
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Wed Sep 07 00:00:00 EDT 2016
Expression of the inhibitory Ly49E receptor is not critically involved in the immune response against cutaneous, pulmonary or liver tumours.
Scientific reports
Filtjens J,Keirsse J,Van Ammel E,Taveirne S,Van Acker A,Kerre T,Taghon T,Vandekerckhove B,Plum J,Van Ginderachter JA,Leclercq G
12-5941 was used in Flow cytometry/Cell sorting to study the involvement of the inhibitory Ly49E NK cell receptor and its activating molecule uPA in skin, lung, and liver tumorigenesis.
Fri Jul 29 00:00:00 EDT 2016
Murine Splenic Natural Killer Cells Do Not Develop Immunological Memory after Re-Encounter with Mycobacterium bovis BCG.
PloS one
Kawahara M,Hasegawa N,Takaku H
12-5941 was used in Flow cytometry/Cell sorting to examine the manner of activation of, and the acquisition of specific memory by, natural killer cells following Bacillus Calmette-Guérin vaccination.
Sun Jul 31 00:00:00 EDT 2016
CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFNγ production and tumor control.
Oncoimmunology
Veinotte L,Gebremeskel S,Johnston B
12-5941 was used in Flow cytometry/Cell sorting to study the co-stimulatory role of CXCR6/CXCL16 interactions in glycolipid-dependent invariant natural killer T (iNKT) cell activation and tumour control, showing that CXCL16-positive dendritic cells enhance iNKT cell-dependent IFNγ production and tumor control.
Wed Jun 01 00:00:00 EDT 2016
Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential.
PloS one
Qualai J,Li LX,Cantero J,Tarrats A,Fernández MA,Sumoy L,Rodolosse A,McSorley SJ,Genescà M
12-5941 was used in Flow cytometry/Cell sorting to find markers associated with non-conventional T cell subsets, including γδ T cells and invariant natural killer T cells.
Thu Mar 16 00:00:00 EDT 2017
Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma.
Nature immunology
Finkin S,Yuan D,Stein I,Taniguchi K,Weber A,Unger K,Browning JL,Goossens N,Nakagawa S,Gunasekaran G,Schwartz ME,Kobayashi M,Kumada H,Berger M,Pappo O,Rajewsky K,Hoshida Y,Karin M,Heikenwalder M,Ben-Neriah Y,Pikarsky E
12-5941 was used in Flow cytometry/Cell sorting to reveal the function of ectopic lymphoid-like structures in cancer.
Tue Dec 01 00:00:00 EST 2015
CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia.
Cell stem cell
Iwasaki M,Liedtke M,Gentles AJ,Cleary ML
12-5941 was used in Flow cytometry/Cell sorting to study how CD93 expression may indicate leukaemia initiating stem cells that have a MLL gene rearrangement.
Thu Oct 01 00:00:00 EDT 2015
Pulmonary receptor for advanced glycation end-products promotes asthma pathogenesis through IL-33 and accumulation of group 2 innate lymphoid cells.
The Journal of allergy and clinical immunology
Oczypok EA,Milutinovic PS,Alcorn JF,Khare A,Crum LT,Manni ML,Epperly MW,Pawluk AM,Ray A,Oury TD
12-5941 was used in Flow cytometry/Cell sorting to demonstrate how the parenchymal factor RAGE mediates lung-specific accumulation of ILC2s that drive allergic airway inflammation in mice.
Tue Sep 01 00:00:00 EDT 2015
B cell autophagy mediates TLR7-dependent autoimmunity and inflammation.
Autophagy
Weindel CG,Richey LJ,Bolland S,Mehta AJ,Kearney JF,Huber BT
12-5941-82 was used in Flow Cytometry to demonstrate that autophagy plays an essential role in TLR7 activation of B cells for the induction of systemic lupus erythematosus.
Mon Apr 18 00:00:00 EDT 2016
Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection.
Journal of immunology (Baltimore, Md. : 1950)
Bardina SV,Michlmayr D,Hoffman KW,Obara CJ,Sum J,Charo IF,Lu W,Pletnev AG,Lim JK
12-5941 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms of inflammatory monocyte migration in West Nile Virus encephalitis, showing differential roles of CCL2 and CCL7 in monocytosis and leukocyte migration.
Sun Nov 01 00:00:00 EDT 2015
Interferon-γ-Mediated Natural Killer Cell Activation by an Aqueous Panax ginseng Extract.
Evidence-based complementary and alternative medicine : eCAM
Takeda K,Okumura K
12-5941 was used in Flow cytometry/Cell sorting to examine the effects of P. ginseng extracts on the cytotoxic activity of NK cells.
Wed Dec 09 00:00:00 EST 2015
Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.
PloS one
Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Thu Apr 28 00:00:00 EDT 2016
Metronomic cyclophosphamide eradicates large implanted GL261 gliomas by activating antitumor Cd8+ T-cell responses and immune memory.
Oncoimmunology
Wu J,Waxman DJ
12-5941 was used in Flow cytometry/Cell sorting to prove that single-agent chemotherapy can eradicate large, established tumours and induce long-term immune memory.
Wed Apr 01 00:00:00 EDT 2015
Alleviation of skin inflammation after Lin(-) cell transplantation correlates with their differentiation into myeloid-derived suppressor cells.
Scientific reports
Jeong Ryu S,Ju JM,Kim W,Bum Kim M,Hee Oh K,Sup Lee D,Lee H,Eun Oh J,Soo Park K,Young Choi E
Tue Oct 06 00:00:00 EDT 2015
Identification of a unique TGF-β-dependent molecular and functional signature in microglia.
Nature neuroscience
Butovsky O,Jedrychowski MP,Moore CS,Cialic R,Lanser AJ,Gabriely G,Koeglsperger T,Dake B,Wu PM,Doykan CE,Fanek Z,Liu L,Chen Z,Rothstein JD,Ransohoff RM,Gygi SP,Antel JP,Weiner HL
12-5941 was used in Flow cytometry/Cell sorting to study gene expression in microglia versus myeloid and other immune cells.
Wed Jan 01 00:00:00 EST 2014
Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis.
The Journal of clinical investigation
Zhou HF,Yan H,Pan H,Hou KK,Akk A,Springer LE,Hu Y,Allen JS,Wickline SA,Pham CT
12-5941 was used in Flow cytometry/Cell sorting to investigate the use of siRNAs in targeted blocking of NF-κB signalling.
Wed Oct 01 00:00:00 EDT 2014
Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection.
Hepatology (Baltimore, Md.)
Huang H,Nace GW,McDonald KA,Tai S,Klune JR,Rosborough BR,Ding Q,Loughran P,Zhu X,Beer-Stolz D,Chang EB,Billiar T,Tsung A
12-5941 was used in Flow cytometry/Cell sorting to determine the role of intracellular HMGB1 in hepatocytes after liver ischaemia-reperfusion.
Thu May 01 00:00:00 EDT 2014
Secretion of IL-16 through TNFR1 and calpain-caspase signaling contributes to MRSA pneumonia.
Mucosal immunology
Ahn DS,Parker D,Planet PJ,Nieto PA,Bueno SM,Prince A
12-5941 was used in Flow cytometry/Cell sorting to study the role of IL-16 in disease progression of S. aureus pneumonia.
Sat Nov 01 00:00:00 EDT 2014
The Vi capsular polysaccharide enables Salmonella enterica serovar typhi to evade microbe-guided neutrophil chemotaxis.
PLoS pathogens
Wangdi T,Lee CY,Spees AM,Yu C,Kingsbury DD,Winter SE,Hastey CJ,Wilson RP,Heinrich V,Bäumler AJ
12-5941 was used in Flow cytometry/Cell sorting to study how the expression of the Vi capsular polysaccharide of S. Typhi obstructs bacterial-guided neutrophil chemotaxis.
Fri Aug 01 00:00:00 EDT 2014
An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
White AJ,Jenkinson WE,Cowan JE,Parnell SM,Bacon A,Jones ND,Jenkinson EJ,Anderson G
12-5941 was used in Flow cytometry/Cell sorting to investigate whether thymus microenvironments are required in iNKT cell development, showing that medullary thymic epithelial cells are essential for intrathymic development of iNKT cells.
Sat Mar 15 00:00:00 EDT 2014
The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage.
Journal of immunology (Baltimore, Md. : 1950)
Lee PH,Puppi M,Schluns KS,Yu-Lee LY,Dong C,Lacorazza HD
12-5941 was used in Flow cytometry/Cell sorting to purified cells CD4+ T cells are inhibited from differentiating into Th17 cells by E74-like Factor 4.
Wed Jan 01 00:00:00 EST 2014
Defect of CARD9 leads to impaired accumulation of gamma interferon-producing memory phenotype T cells in lungs and increased susceptibility to pulmonary infection with Cryptococcus neoformans.
Infection and immunity
Yamamoto H,Nakamura Y,Sato K,Takahashi Y,Nomura T,Miyasaka T,Ishii K,Hara H,Yamamoto N,Kanno E,Iwakura Y,Kawakami K
12-5941 was used in Flow cytometry/Cell sorting to suggest CARD9 KO mice are susceptible to C. neoformans infection due to reduced IFN-γ expressing NK and memory T-cells.
Tue Apr 01 00:00:00 EDT 2014
Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface.
PloS one
Habbeddine M,Verbeke P,Karaz S,Bobé P,Kanellopoulos-Langevin C
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Wed Jun 10 00:00:00 EDT 2015
The use of anchored agonists of phagocytic receptors for cancer immunotherapy: B16-F10 murine melanoma model.
PloS one
Janotová T,Jalovecká M,Auerová M,Švecová I,Bruzlová P,Maierová V,Kumžáková Z,Cunátová Š,Vlčková Z,Caisová V,Rozsypalová P,Lukáčová K,Vácová N,Wachtlová M,Salát J,Lieskovská J,Kopecký J,Ženka J
12-5941 was used in Flow cytometry/Cell sorting to assess the anti-tumour potential of fusing phagocytic receptor agonists to cancer cells.
Thu Sep 18 00:00:00 EDT 2014
A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors.
The Journal of experimental medicine
Chen YL,Chen TT,Pai LM,Wesoly J,Bluyssen HA,Lee CK
12-5941 was used in Flow cytometry/Cell sorting to define a critical role for the FL/IFN-I/Flt3 axis in plasmacytoid dendritic cell differentiation from common lymphoid progenitors.
Mon Nov 18 00:00:00 EST 2013
Infiltrating macrophages are key to the development of seizures following virus infection.
Journal of virology
Cusick MF,Libbey JE,Patel DC,Doty DJ,Fujinami RS
12-5941 was used in Flow cytometry/Cell sorting to implicate infiltrating macrophages as an important source of interleukin-6 that contributes to the development of acute seizures.
Fri Feb 01 00:00:00 EST 2013
IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans.
Journal of immunology (Baltimore, Md. : 1950)
Flaczyk A,Duerr CU,Shourian M,Lafferty EI,Fritz JH,Qureshi ST
12-5941 was used in Flow cytometry/Cell sorting to study how allergic patterns of lung inflammation are mediated as a host response to Cryptococcus neoformans infection.
Sun Sep 01 00:00:00 EDT 2013
Histones activate the NLRP3 inflammasome in Kupffer cells during sterile inflammatory liver injury.
Journal of immunology (Baltimore, Md. : 1950)
Huang H,Chen HW,Evankovich J,Yan W,Rosborough BR,Nace GW,Ding Q,Loughran P,Beer-Stolz D,Billiar TR,Esmon CT,Tsung A
12-5941 was used in Flow cytometry/Cell sorting to investigate the cellular processes that drive sterile inflammatory injury after hepatic ischaemia/reperfusion injury.
Sun Sep 01 00:00:00 EDT 2013
Sox4 is required for the survival of pro-B cells.
Journal of immunology (Baltimore, Md. : 1950)
Sun B,Mallampati S,Gong Y,Wang D,Lefebvre V,Sun X
12-5941 was used in Flow cytometry/Cell sorting to investigate the role of Sox4 in development of mature B cells, showing that it is required for pro-B cell survival.
Fri Mar 01 00:00:00 EST 2013
Human IL-2 mutein with higher antitumor efficacy than wild type IL-2.
Journal of immunology (Baltimore, Md. : 1950)
Carmenate T,Pacios A,Enamorado M,Moreno E,Garcia-Martínez K,Fuente D,León K
12-5941 was used in Flow cytometry/Cell sorting to characterise a human IL-2 mutant for used intreatment of melanoma and renal cell carcinoma, showing that mutant IL-2 has a higher antitumor efficacy and lower toxicity than wild type IL-2.
Sat Jun 15 00:00:00 EDT 2013
Migration of CD11b+ accessory cells during murine lung regeneration.
Stem cell research
Chamoto K,Gibney BC,Lee GS,Ackermann M,Konerding MA,Tsuda A,Mentzer SJ
12-5941 was used in Flow cytometry/Cell sorting to characterise the factors contributing to neoalveolarization within 21 days of pneumonectomy.
Wed May 01 00:00:00 EDT 2013
Role of NK cell subsets in organ-specific murine melanoma metastasis.
PloS one
Ballas ZK,Buchta CM,Rosean TR,Heusel JW,Shey MR
12-5941 was used in Flow cytometry/Cell sorting to examine the organ-specific functions of natural killer cells.
Thu Jan 16 00:00:00 EST 2014
Streptomycin-induced inflammation enhances Escherichia coli gut colonization through nitrate respiration.
mBio
Spees AM,Wangdi T,Lopez CA,Kingsbury DD,Xavier MN,Winter SE,Tsolis RM,Bäumler AJ
12-5941 was used in Flow cytometry/Cell sorting to identify streptomycin-induced changes in the gut that lower resistance to colonisation by facultative anaerobic bacteria.
Tue Jul 02 00:00:00 EDT 2013
Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue.
The Journal of biological chemistry
Patnode ML,Cheng CW,Chou CC,Singer MS,Elin MS,Uchimura K,Crocker PR,Khoo KH,Rosen SD
12-5941 was used in Flow cytometry/Cell sorting to investigate whether keratan sulfate galactose 6-O-sulfotransferase and chondroitin 6-O-sulfotransferase 1 are required for the generation of endogenous Siglec-F ligands.
Fri Sep 13 00:00:00 EDT 2013
Partial depletion of regulatory T cells does not influence the inflammation caused by high dose hemi-body irradiation.
PloS one
Ma S,Richardson JA,Bitmansour A,Solberg TD,Pidikiti R,Song K,Stojadinovic S,Vitetta ES,Meyer JJ
12-5941 was used in Flow cytometry/Cell sorting to investigate the effects of partial depletion of regulatory T cells alongside ionizing radiation on inflammation and tissue injury in mice.
Mon Jul 29 00:00:00 EDT 2013
G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising CD8+ T cell immune responses.
Journal of hematology & oncology
Rubinstein MP,Salem ML,Doedens AL,Moore CJ,Chiuzan C,Rivell GL,Cole DJ,Goldrath AW
12-5941 was used in Flow cytometry/Cell sorting to evaluate whether the biological activity of G-CSF can be improved by pre-association with anti-G-CSF monoclonal antibodies prior to injection.
Tue Oct 01 00:00:00 EDT 2013
NF-Y is necessary for hematopoietic stem cell proliferation and survival.
Blood
Bungartz G,Land H,Scadden DT,Emerson SG
12-5941 was used in Flow cytometry/Cell sorting to show that the trimeric transcription factor NF-Y is critical for the survival of cycling, but not quiescent hematopoietic stem cells.
Thu Feb 09 00:00:00 EST 2012
Thymus-autonomous T cell development in the absence of progenitor import.
The Journal of experimental medicine
Martins VC,Ruggiero E,Schlenner SM,Madan V,Schmidt M,Fink PJ,von Kalle C,Rodewald HR
12-5941 was used in Flow cytometry/Cell sorting to characterise the previously unrecognised capacity of the thymus to sustain T cell development during bone marrow progenitor deprivation.
Mon Jul 30 00:00:00 EDT 2012
IL-33 induces innate lymphoid cell-mediated airway inflammation by activating mammalian target of rapamycin.
The Journal of allergy and clinical immunology
Salmond RJ,Mirchandani AS,Besnard AG,Bain CC,Thomson NC,Liew FY
12-5941 was used in Flow cytometry/Cell sorting to investigate the role of mTOR signalling in the activation of TH2, ILC and IL-33 inflammation responses.
Thu Nov 01 00:00:00 EDT 2012
VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression.
Cancer research
Doloff JC,Waxman DJ
Published figure using NK1.1 monoclonal antibody (Product # 12-5941-82) in Flow Cytometry
Thu Mar 01 00:00:00 EST 2012
Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression.
Journal of leukocyte biology
Rossi LE,Avila DE,Spallanzani RG,Ziblat A,Fuertes MB,Lapyckyj L,Croci DO,Rabinovich GA,Domaica CI,Zwirner NW
12-5941 was used in Flow cytometry/Cell sorting to investigate the effect of histone deacetylase inhibitors on immune cells, showing that they can impair NK cell viability and effector functions.
Wed Feb 01 00:00:00 EST 2012
TLR9 and MyD88 are crucial for the development of protective immunity to malaria.
Journal of immunology (Baltimore, Md. : 1950)
Gowda NM,Wu X,Gowda DC
12-5941 was used in Flow cytometry/Cell sorting to investigate TLR9 and MyD88 regulation of pro/anti-inflammatory cytokines in mice infected with Plasmodium yoelii.
Tue May 15 00:00:00 EDT 2012
Splenocyte apoptosis and autophagy is mediated by interferon regulatory factor 1 during murine endotoxemia.
Shock (Augusta, Ga.)
Zhang L,Cardinal JS,Pan P,Rosborough BR,Chang Y,Yan W,Huang H,Billiar TR,Rosengart MR,Tsung A
12-5941 was used in Flow cytometry/Cell sorting to demonstrate that interferon regulatory factor-1 regulates both immune cell apoptosis and autophagy in a murine endotoxemia model.
Tue May 01 00:00:00 EDT 2012
Augmentation of natural cytotoxicity by chronic low-dose ionizing radiation in murine natural killer cells primed by IL-2.
Journal of radiation research
Sonn CH,Choi JR,Kim TJ,Yu YB,Kim K,Shin SC,Park GH,Shirakawa T,Kim HS,Lee KM
12-5941 was used in Flow cytometry/Cell sorting to demonstrate how exposure to LDR can lead to subtle immune-enhancing effects on NK cells.
Thu Nov 01 00:00:00 EDT 2012
Deleterious effect of the IL-23/IL-17A axis and γδT cells on left ventricular remodeling after myocardial infarction.
Journal of the American Heart Association
Yan X,Shichita T,Katsumata Y,Matsuhashi T,Ito H,Ito K,Anzai A,Endo J,Tamura Y,Kimura K,Fujita J,Shinmura K,Shen W,Yoshimura A,Fukuda K,Sano M
12-5941 was used in Flow cytometry/Cell sorting to explore potential immune pathways involved in left ventricular remodelling as possible preventative therapeutic options.
Mon Oct 01 00:00:00 EDT 2012
A critical role for SOCS3 in innate resistance to Toxoplasma gondii.
Cell host & microbe
Whitmarsh RJ,Gray CM,Gregg B,Christian DA,May MJ,Murray PJ,Hunter CA
12-5941 was used in Flow cytometry/Cell sorting to study the role of SOCS3 in suppressing IL-6 signalling during immune responses to T. gondii infection.
Thu Sep 15 00:00:00 EDT 2011
The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance.
The Journal of experimental medicine
Mortensen M,Soilleux EJ,Djordjevic G,Tripp R,Lutteropp M,Sadighi-Akha E,Stranks AJ,Glanville J,Knight S,Jacobsen SE,Kranc KR,Simon AK
12-5941 was used in Flow cytometry/Cell sorting to show that Atg7 is an essential regulator of adult hematopoietic stem cell maintenance.
Mon Mar 14 00:00:00 EDT 2011
Adenovirus-mediated intratumoral expression of immunostimulatory proteins in combination with systemic Treg inactivation induces tumor-destructive immune responses in mouse models.
Cancer gene therapy
Liu Y,Tuve S,Persson J,Beyer I,Yumul R,Li ZY,Tragoolpua K,Hellström KE,Roffler S,Lieber A
12-5941 was used in Flow cytometry/Cell sorting to investigate the effect of αCTLA4 on cancer.
Wed Jun 01 00:00:00 EDT 2011
Adenovirus-mediated intratumoral expression of immunostimulatory proteins in combination with systemic Treg inactivation induces tumor-destructive immune responses in mouse models.
Cancer gene therapy
Liu Y,Tuve S,Persson J,Beyer I,Yumul R,Li ZY,Tragoolpua K,Hellström KE,Roffler S,Lieber A
12-5941 was used in Flow cytometry/Cell sorting to investigate the effect of αCTLA4 on cancer.
Wed Jun 01 00:00:00 EDT 2011
TCR-dependent and -independent activation underlie liver-specific regulation of NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
Subleski JJ,Hall VL,Wolfe TB,Scarzello AJ,Weiss JM,Chan T,Hodge DL,Back TC,Ortaldo JR,Wiltrout RH
12-5941 was used in Flow cytometry/Cell sorting to investigate TCR -dependent and -independent activation of NKT cells in the liver.
Sat Jan 15 00:00:00 EST 2011
IL-37 is a fundamental inhibitor of innate immunity.
Nature immunology
Nold MF,Nold-Petry CA,Zepp JA,Palmer BE,Bufler P,Dinarello CA
12-5941 was used in Flow cytometry/Cell sorting to determine the function of interleukin 37.
Mon Nov 01 00:00:00 EDT 2010
Oral administration of an active form of vitamin D3 (calcitriol) decreases atherosclerosis in mice by inducing regulatory T cells and immature dendritic cells with tolerogenic functions.
Arteriosclerosis, thrombosis, and vascular biology
Takeda M,Yamashita T,Sasaki N,Nakajima K,Kita T,Shinohara M,Ishida T,Hirata K
12-5941 was used in Flow cytometry/Cell sorting to demonstrate that immune modulation by calcitriol may be a potentially valuable therapeutic approach against atherosclerosis.
Wed Dec 01 00:00:00 EST 2010
Interleukin-15 is critical in the pathogenesis of influenza a virus-induced acute lung injury.
Journal of virology
Nakamura R,Maeda N,Shibata K,Yamada H,Kase T,Yoshikai Y
12-5941 was used in Flow cytometry/Cell sorting to determine why interleukin-15 knockout mice exhibit reduced mortality after infection with influenza virus A.
Tue Jun 01 00:00:00 EDT 2010
Fine-scale staging of T cell lineage commitment in adult mouse thymus.
Journal of immunology (Baltimore, Md. : 1950)
Yui MA,Feng N,Rothenberg EV
12-5941 was used in Flow cytometry/Cell sorting to determine the gene regulatory changes that accompany commitment in adult wild-type double-negative adult thymocytes.
Thu Jul 01 00:00:00 EDT 2010
A role for granzyme M in TLR4-driven inflammation and endotoxicosis.
Journal of immunology (Baltimore, Md. : 1950)
Anthony DA,Andrews DM,Chow M,Watt SV,House C,Akira S,Bird PI,Trapani JA,Smyth MJ
12-5941 was used in Flow cytometry/Cell sorting to demonstrate that granzymes should be considered as potential key regulators of inflammation.
Sun Aug 01 00:00:00 EDT 2010
Efficient isolation of mouse liver NKT cells by perfusion.
PloS one
Fang X,Du P,Liu Y,Tang J
12-5941 was used in Flow cytometry/Cell sorting to develop a simple method to isolate NKT cells using perfusion, with similar yield to the traditional methods.
Wed Apr 21 00:00:00 EDT 2010
Invariant natural killer T cells suppress the neutrophil inflammatory response in a mouse model of cholestatic liver damage.
Gastroenterology
Wintermeyer P,Cheng CW,Gehring S,Hoffman BL,Holub M,Brossay L,Gregory SH
12-5941 was used in Flow cytometry/Cell sorting to show the role of iNKT cells in suppressing the neutrophil proinflammatory response and neutrophil-dependent cholestatic liver damage.
Sun Mar 01 00:00:00 EST 2009
Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury.
Journal of the American Society of Nephrology : JASN
Kinsey GR,Sharma R,Huang L,Li L,Vergis AL,Ye H,Ju ST,Okusa MD
12-5941 was used in Flow cytometry/Cell sorting to investigate whether the anti-inflammatory effects of CD4(+)CD25(+)FoxP3(+) Tregs protect against renal IRI.
Sat Aug 01 00:00:00 EDT 2009
Dendritic cells are required for optimal activation of natural killer functions following primary infection with herpes simplex virus type 1.
Journal of virology
Kassim SH,Rajasagi NK,Ritz BW,Pruett SB,Gardner EM,Chervenak R,Jennings SR
12-5941 was used in Flow cytometry/Cell sorting to provide evidence that functional DCs are required for optimal IFN-gamma expression and cytolytic function by NK cells following HSV-1 infection.
Wed Apr 01 00:00:00 EDT 2009
Gammadelta T lymphocyte homeostasis is negatively regulated by beta2-microglobulin.
Journal of immunology (Baltimore, Md. : 1950)
French JD,Roark CL,Born WK,O'Brien RL
12-5941 was used in Flow cytometry/Cell sorting to investigate the role of β2-microglobulin in regulating gamma-delta T lymphocyte homeostasis.
Sun Feb 15 00:00:00 EST 2009
Treatment with LL-37 peptide enhances antitumor effects induced by CpG oligodeoxynucleotides against ovarian cancer.
Human gene therapy
Chuang CM,Monie A,Wu A,Mao CP,Hung CF
12-5941 was used in Flow cytometry/Cell sorting to demonstrate the potential of combined CpG-ODN-LL-37 peptide treatment for the control of ovarian tumours.
Wed Apr 01 00:00:00 EDT 2009
Interaction of Cowpea mosaic virus (CPMV) nanoparticles with antigen presenting cells in vitro and in vivo.
PloS one
Gonzalez MJ,Plummer EM,Rae CS,Manchester M
12-5941 was used in Flow cytometry/Cell sorting to demonstrate that Cowpea mosaic virus is bound and internalised by subsets of several populations of antigen presenting cells.
Mon Nov 23 00:00:00 EST 2009
IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.
Blood
Rubinstein MP,Lind NA,Purton JF,Filippou P,Best JA,McGhee PA,Surh CD,Goldrath AW
12-5941 was used in Flow cytometry/Cell sorting to study IL-7 and IL-15 regulation of CD8+ T-cell subsets during contraction of the immune response.
Sat Nov 01 00:00:00 EDT 2008
DNAM-1 promotes activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors.
The Journal of experimental medicine
Gilfillan S,Chan CJ,Cella M,Haynes NM,Rapaport AS,Boles KS,Andrews DM,Smyth MJ,Colonna M
12-5941 was used in Flow cytometry/Cell sorting to study the promoted activation of cytotoxic lymphocytes by nonprofessional antigen-presenting cells and tumors by dnam-1.
Mon Dec 22 00:00:00 EST 2008
Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome.
The American journal of pathology
Gongora MC,Lob HE,Landmesser U,Guzik TJ,Martin WD,Ozumi K,Wall SM,Wilson DS,Murthy N,Gravanis M,Fukai T,Harrison DG
12-5941 was used in Flow cytometry/Cell sorting to study the role of acute SOD3 reduction in lung injury.
Wed Oct 01 00:00:00 EDT 2008
The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells.
Blood
Kishimoto H,Ohteki T,Yajima N,Kawahara K,Natsui M,Kawarasaki S,Hamada K,Horie Y,Kubo Y,Arase S,Taniguchi M,Vanhaesebroeck B,Mak TW,Nakano T,Koyasu S,Sasaki T,Suzuki A
12-5941 was used in Flow cytometry/Cell sorting to describe the phenotype of Pten-deficient Valpha14iNKT cells.
Sun Apr 15 00:00:00 EDT 2007
Measles virus infection of SLAM (CD150) knockin mice reproduces tropism and immunosuppression in human infection.
Journal of virology
Ohno S,Ono N,Seki F,Takeda M,Kura S,Tsuzuki T,Yanagi Y
12-5941 was used in Flow cytometry/Cell sorting to investigate the effects on measles infection after replacement of the V domain of mouse SLAM with human SLAM.
Thu Feb 01 00:00:00 EST 2007
Poly I:C prevents T cell-mediated hepatitis via an NK-dependent mechanism.
Journal of hepatology
Wang J,Sun R,Wei H,Dong Z,Gao B,Tian Z
12-5941 was used in Flow cytometry/Cell sorting to study the prevention of T-cell mediated hepatitis by Poly I:C via an NK-dependent mechanism.
Wed Mar 01 00:00:00 EST 2006
Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation.
The Journal of experimental medicine
Lappas CM,Day YJ,Marshall MA,Engelhard VH,Linden J
12-5941 was used in Flow cytometry/Cell sorting to suggest that hepatic reperfusion injury is initiated by the CD1d-dependent activation of NKT cells.
Mon Nov 27 00:00:00 EST 2006
Fusion proteins of Hsp70 with tumor-associated antigen acting as a potent tumor vaccine and the C-terminal peptide-binding domain of Hsp70 being essential in inducing antigen-independent anti-tumor response in vivo.
Cell stress & chaperones
Zhang H,Huang W
12-5941 was used in Flow cytometry/Cell sorting to find that immunization with multiple Hsp70 fusion proteins resulted in a better anti-tumor effect.
Thu Oct 26 00:00:00 EDT 2006
{gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells.
Proceedings of the National Academy of Sciences of the United States of America
French JD,Roark CL,Born WK,O'brien RL
12-5941 was used in Flow cytometry/Cell sorting to investigate how CD8(+) alphabeta T cells are the most potent inhibitors of gammadelta T cell homeostasis and exert their effect by competing for IL-15.
Tue Oct 11 00:00:00 EDT 2005
Cross-presentation of disialoganglioside GD3 to natural killer T cells.
The Journal of experimental medicine
Wu DY,Segal NH,Sidobre S,Kronenberg M,Chapman PB
12-5941 was used in Flow cytometry/Cell sorting to demonstrate that immunising mice with the SK-MEL-28 cell line or with syngeneic APCs loaded with GD3 can induce a GD3-reactive natural killer T cell response.
Mon Jul 07 00:00:00 EDT 2003
