Product References
A combination of genetically engineered oncolytic virus and melittin-CpG for cancer viro-chemo-immunotherapy.
BMC medicine
Bahreyni A,Liu H,Mohamud Y,Xue YC,Fan YM,Zhang YL,Luo H
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Immunohistochemistry
Wed May 24 00:00:00 EDT 2023
Protocol for PPP1R15A-inhibited mouse model establishment with subcutaneous B16F1 tumor and single-cell analysis.
STAR protocols
Wang R,Wang M,Pei S,Zhang Y,Guo S,Guo W,Wu Z,Wang H,Li Y,Zhu Y,Meng LH,Lang J,Jin G,Xiao Y,Hu L,Kong X
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Fri Dec 15 00:00:00 EST 2023
MCL-1 Inhibitor S63845 Distinctively Affects Intramedullary and Extramedullary Hematopoiesis.
Pharmaceutics
Zhang H,Li F,Yang M,Zhang W,He M,Xu H,Wang C,Zhang Y,Wang W,Gao Y,Du X,Li Y
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Tue Mar 28 00:00:00 EDT 2023
Peripheral Neutrophils-Derived Matrix Metallopeptidase-9 Induces Postoperative Cognitive Dysfunction in Aged Mice.
Frontiers in aging neuroscience
Huang L,Tian W,Chen X,Xu H,Dai W,Zhang Y,Wu X,Yu W,Tian J,Su D
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Mon Mar 14 00:00:00 EDT 2022
NK cells require immune checkpoint receptor LILRB4/gp49B to control neurotropic Zika virus infections in mice.
JCI insight
Lee HN,Manangeeswaran M,Lewkowicz AP,Engel K,Chowdhury M,Garige M,Eckhaus MA,Sourbier C,Ireland DD,Verthelyi D
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Tue Feb 08 00:00:00 EST 2022
Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage.
Cell death & disease
Del Rio Oliva M,Basler M
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2022
The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude.
The Journal of experimental medicine
Li ZY,Morman RE,Hegermiller E,Sun M,Bartom ET,Maienschein-Cline M,Sigvardsson M,Kee BL
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Mon Jun 07 00:00:00 EDT 2021
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.
The Journal of experimental medicine
Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Mon Aug 02 00:00:00 EDT 2021
The Effect of miR-520b on Macrophage Polarization and T Cell Immunity by Targeting PTEN in Breast Cancer.
Journal of oncology
Zhu Q,Yuan J,He Y,Hu Y
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Immunohistochemistry
Wed Apr 27 00:00:00 EDT 2022
Exosomal lncRNA SNHG10 derived from colorectal cancer cells suppresses natural killer cell cytotoxicity by upregulating INHBC.
Cancer cell international
Huang Y,Luo Y,Ou W,Wang Y,Dong D,Peng X,Luo Y
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
Expression of CCRL2 Inhibits Tumor Growth by Concentrating Chemerin and Inhibiting Neoangiogenesis.
Cancers
Al Delbany D,Robert V,Dubois-Vedrenne I,Del Prete A,Vernimmen M,Radi A,Lefort A,Libert F,Wittamer V,Sozzani S,Parmentier M
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Tue Oct 05 00:00:00 EDT 2021
Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.
EBioMedicine
Okada R,Furusawa A,Vermeer DW,Inagaki F,Wakiyama H,Kato T,Nagaya T,Choyke PL,Spanos WC,Allen CT,Kobayashi H
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
A novel miR1983-TLR7-IFNβ circuit licenses NK cells to kill glioma cells, and is under the control of galectin-1.
Oncoimmunology
Shah D,Comba A,Faisal SM,Kadiyala P,Baker GJ,Alghamri MS,Doherty R,Zamler D,Nuñez G,Castro MG,Lowenstein PR
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Mon Aug 02 00:00:00 EDT 2021
Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation.
eLife
Wilfahrt D,Philips RL,Lama J,Kizerwetter M,Shapiro MJ,McCue SA,Kennedy MM,Rajcula MJ,Zeng H,Shapiro VS
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Protein Assays and Analysis
Thu Dec 02 00:00:00 EST 2021
Sequencing, cloning, and antigen binding analysis of monoclonal antibodies isolated from single mouse B cells.
STAR protocols
Viant C,Escolano A,Chen ST,Nussenzweig MC
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Fri Jun 18 00:00:00 EDT 2021
The enrichment of neutrophil extracellular traps impair the placentas of systemic lupus erythematosus through accumulating decidual NK cells.
Scientific reports
Jiang M,Shen N,Zhou H,Wang Y,Lin S,Wu J,Di W
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Thu Mar 25 00:00:00 EDT 2021
Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer.
Cell research
Wang S,Qu Y,Xia P,Chen Y,Zhu X,Zhang J,Wang G,Tian Y,Ying J,Fan Z
14-5941-82 was used in Flow Cytometry to profile tumor infiltrating innate lymphoid cells in colorectal cancer at early and late stages.
Wed Jul 01 00:00:00 EDT 2020
Hippo Signaling Pathway Has a Critical Role in Zika Virus Replication and in the Pathogenesis of Neuroinflammation.
The American journal of pathology
Garcia G,Paul S,Beshara S,Ramanujan VK,Ramaiah A,Nielsen-Saines K,Li MMH,French SW,Morizono K,Kumar A,Arumugaswami V
14-5941-82 was used in Immunohistochemistry to study the pathophysiological mechanisms of Zika virus-mediated ocular and neuronal pathology.
Wed Apr 01 00:00:00 EDT 2020
Secreted Phospholipase A2 Group X Acts as an Adjuvant for Type 2 Inflammation, Leading to an Allergen-Specific Immune Response in the Lung.
Journal of immunology (Baltimore, Md. : 1950)
Ogden HL,Lai Y,Nolin JD,An D,Frevert CW,Gelb MH,Altemeier WA,Hallstrand TS
14-5941-82 was used in Flow Cytometry to demonstrate that exogenous and endogenous sPLA2s play an important role in peripheral sensitization, resulting in airway responses to inhaled Ags.
Mon Jun 15 00:00:00 EDT 2020
Intestinal vitamin D receptor knockout protects from oxazolone-induced colitis.
Cell death & disease
Shi Y,Liu Z,Cui X,Zhao Q,Liu T
14-5941 was used in Western Blotting to identify that intestinal vitamin D receptor knockout protected against oxazolone-induced colitis in mice by blocking Th2 cell response and reducing the function of intestinal invariant natural killer T cells.
Mon Jun 15 00:00:00 EDT 2020
Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.
STAR protocols
Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Fri Jun 19 00:00:00 EDT 2020
Dendritic Cells and Myeloid Derived Suppressor Cells Fully Responsive to Stimulation via Toll-Like Receptor 4 Are Rapidly Induced from Bone-Marrow Cells by Granulocyte-Macrophage Colony-Stimulating Factor.
Vaccines
Kong YY,Wilson K,Apostolopoulos V,Plebanski M
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Sat Sep 12 00:00:00 EDT 2020
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.
Nature
Escolano A,Gristick HB,Abernathy ME,Merkenschlager J,Gautam R,Oliveira TY,Pai J,West AP,Barnes CO,Cohen AA,Wang H,Golijanin J,Yost D,Keeffe JR,Wang Z,Zhao P,Yao KH,Bauer J,Nogueira L,Gao H,Voll AV,Montefiori DC,Seaman MS,Gazumyan A,Silva M,McGuire AT,Stamatatos L,Irvine DJ,Wells L,Martin MA,Bjorkman PJ,Nussenzweig MC
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Sat Jun 01 00:00:00 EDT 2019
Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis.
Blood
Albeituni S,Verbist KC,Tedrick PE,Tillman H,Picarsic J,Bassett R,Nichols KE
14-5941-82 was used in Flow Cytometry to show that ruxolitinib operates through IFN-γ-dependent and -independent mechanisms to dampen HLH by targeting the deleterious effects of T cells and neutrophils, with the latter representing an unappreciated and understudied cell type that contributes to HLH pathogenesis.
Thu Jul 11 00:00:00 EDT 2019
Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria.
The Journal of experimental medicine
Melo-Gonzalez F,Kammoun H,Evren E,Dutton EE,Papadopoulou M,Bradford BM,Tanes C,Fardus-Reid F,Swann JR,Bittinger K,Mabbott NA,Vallance BA,Willinger T,Withers DR,Hepworth MR
14-5941-82 was used in Flow Cytometry to study the mechanisms that modulate the magnitude and quality of T cell-dependent IgA responses.
Mon Apr 01 00:00:00 EDT 2019
miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity.
PLoS biology
Łyszkiewicz M,Winter SJ,Witzlau K,Föhse L,Brownlie R,Puchałka J,Verheyden NA,Kunze-Schumacher H,Imelmann E,Blume J,Raha S,Sekiya T,Yoshimura A,Frueh JT,Ullrich E,Huehn J,Weiss S,Gutierrez MG,Prinz I,Zamoyska R,Ziętara N,Krueger A
14-5941-82 was used in Flow Cytometry to propose that intrathymic miR-181a/b-1 controls development of Treg cells and imposes a developmental legacy on their peripheral function.
Fri Mar 01 00:00:00 EST 2019
Inhibition of T cell activation and function by the adaptor protein CIN85.
Science signaling
Kong MS,Hashimoto-Tane A,Kawashima Y,Sakuma M,Yokosuka T,Kometani K,Onishi R,Carpino N,Ohara O,Kurosaki T,Phua KK,Saito T
14-5941-82 was used in Flow Cytometry to show that CIN85 (Cbl-interacting protein of 85 kDa) limited T cell responses to T cell receptor stimulation.
Tue Feb 05 00:00:00 EST 2019
Diabetes-mediated IL-17A enhances retinal inflammation, oxidative stress, and vascular permeability.
Cellular immunology
Sigurdardottir S,Zapadka TE,Lindstrom SI,Liu H,Taylor BE,Lee CA,Kern TS,Taylor PR
14-5941-82 was used in Flow Cytometry to examine the role of IL-17A in the development of retinal inflammation and long-term vascular pathology in diabetic mice.
Mon Jul 01 00:00:00 EDT 2019
Deletion of C-C Motif Chemokine Ligand 5 Worsens Invariant Natural Killer T-Cell-Mediated Hepatitis via Compensatory Up-regulation of CXCR2-Related Chemokine Activity.
Cellular and molecular gastroenterology and hepatology
Chen L,Gu J,Qian Y,Li M,Qian Y,Xu M,Li J,Wen Y,Xia L,Li J,Xia Q,Kong X,Wu H
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Tue Jun 04 00:00:00 EDT 2019
Synergized regulation of NK cell education by NKG2A and specific Ly49 family members.
Nature communications
Zhang X,Feng J,Chen S,Yang H,Dong Z
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Fri Nov 01 00:00:00 EDT 2019
Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells.
JCI insight
Huang A,Shinde PV,Huang J,Senff T,Xu HC,Margotta C,Häussinger D,Willnow TE,Zhang J,Pandyra AA,Timm J,Weggen S,Lang KS,Lang PA
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Thu Sep 05 00:00:00 EDT 2019
Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia.
Nature communications
Hayashi Y,Goyama S,Liu X,Tamura M,Asada S,Tanaka Y,Fukuyama T,Wunderlich M,O'Brien E,Mizukawa B,Yamazaki S,Matsumoto A,Yamasaki S,Shibata T,Matsuda K,Sashida G,Takizawa H,Kitamura T
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Fri Oct 25 00:00:00 EDT 2019
Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses.
eLife
Carpentier KS,Davenport BJ,Haist KC,McCarthy MK,May NA,Robison A,Ruckert C,Ebel GD,Morrison TE
14-5941-82 was used in Flow Cytometry to reveal a previously unrecognized innate immune pathway that controls alphavirus viremia and dissemination in vertebrate hosts, ultimately influencing disease severity and likely transmission efficiency.
Wed Oct 09 00:00:00 EDT 2019
Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection.
Frontiers in immunology
Schreiber M,Weigelt M,Karasinsky A,Anastassiadis K,Schallenberg S,Petzold C,Bonifacio E,Kretschmer K,Hommel A
14-5941 was used in Flow cytometry/Cell sorting to show that transient hyperexpression of IL-7 can impair immune regulation, through disturbances in lymphocyte development pathways, and decrease graft survival time, even under immunosuppression.
Mon Sep 14 00:00:00 EDT 2020
Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.
Oncoimmunology
Salerno F,Guislain A,Freen-Van Heeren JJ,Nicolet BP,Young HA,Wolkers MC
14-5941 was used in Flow cytometry/Cell sorting to conclude that post-transcriptional mechanisms could be modulated to potentiate effective T cell therapies in cancer.
Tue Jan 12 00:00:00 EST 2021
Female and male mouse lung group 2 innate lymphoid cells differ in gene expression profiles and cytokine production.
PloS one
Mathä L,Shim H,Steer CA,Yin YH,Martinez-Gonzalez I,Takei F
14-5941-82 was used in Flow Cytometry to suggest that female ILC2s are more readily activated than male ILC2s due to their gene expression at the naïve state, which is potentially influenced by the lung environment.
Mon Dec 16 00:00:00 EST 2019
Endogenous glucocorticoids control host resistance to viral infection through the tissue-specific regulation of PD-1 expression on NK cells.
Nature immunology
Quatrini L,Wieduwild E,Escaliere B,Filtjens J,Chasson L,Laprie C,Vivier E,Ugolini S
14-5941 was used in Flow cytometry/Cell sorting to study the pleiotropic effects of endogenous glucocorticoids and their role in response to viral infection.
Sat Sep 01 00:00:00 EDT 2018
Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy.
Nature immunology
Barkal AA,Weiskopf K,Kao KS,Gordon SR,Rosental B,Yiu YY,George BM,Markovic M,Ring NG,Tsai JM,McKenna KM,Ho PY,Cheng RZ,Chen JY,Barkal LJ,Ring AM,Weissman IL,Maute RL
14-5941 was used in Flow cytometry/Cell sorting to demonstrate that expression of the common MHC class I component β2-microglobulin (β2M) by cancer cells directly protects them from phagocytosis.
Mon Jan 01 00:00:00 EST 2018
Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection.
The Journal of experimental medicine
Nair S,Huynh JP,Lampropoulou V,Loginicheva E,Esaulova E,Gounder AP,Boon ACM,Schwarzkopf EA,Bradstreet TR,Edelson BT,Artyomov MN,Stallings CL,Diamond MS
14-5941 was used in Flow cytometry/Cell sorting to study the role of Immune responsive gene 1 in the modulation of inflammation during Mycobacterium tuberculosis infection.
Mon Apr 02 00:00:00 EDT 2018
Co-infection with Chikungunya virus alters trafficking of pathogenic CD8+ T cells into the brain and prevents Plasmodium-induced neuropathology.
EMBO molecular medicine
Teo TH,Howland SW,Claser C,Gun SY,Poh CM,Lee WW,Lum FM,Ng LF,Rénia L
14-5941 was used in Flow cytometry/Cell sorting to study the effects of Chikungunya virus co-infection on the severity and susceptibility of malaria infection.
Mon Jan 01 00:00:00 EST 2018
Natural Killer Cell Recruitment to the Lung During Influenza A Virus Infection Is Dependent on CXCR3, CCR5, and Virus Exposure Dose.
Frontiers in immunology
Carlin LE,Hemann EA,Zacharias ZR,Heusel JW,Legge KL
14-5941 was used in Flow cytometry/Cell sorting to demonstrate that there is an increased accumulation of NK cells in the link in high-dose vs. low-dose infections of influenza A virus.
Fri Jun 07 00:00:00 EDT 2019
IFN-γ protects from apoptotic neutrophil-mediated tissue injury during acute Listeria monocytogenes infection.
European journal of immunology
Wang G,Lin A,Han Q,Zhao H,Tian Z,Zhang J
14-5941-82 was used in Miscellaneous to demonstrate that neutrophils are an important source of IFN-γ at the early stage of LM infection, which is characterized by both LM elimination and tissue-protective effects.
Sat Sep 01 00:00:00 EDT 2018
Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Kostrzewski T,Borg AJ,Meng Y,Filipovic I,Male V,Wack A,DiMaggio PA,Brady HJM
14-5941 was used in Flow cytometry/Cell sorting to reveal mechanisms in NK cell development and that E4bp4 is a central hub to process extrinsic stimuli.
Thu Feb 15 00:00:00 EST 2018
CD8+ T cells mediate the antitumor activity of frankincense and myrrh in hepatocellular carcinoma.
Journal of translational medicine
Xu C,Lu X,Liu W,Chen A,Meng G,Zhang H,Li B,Zhang Y,Wu J,Wei J
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Mon May 21 00:00:00 EDT 2018
Plasmodium co-infection protects against chikungunya virus-induced pathologies.
Nature communications
Teo TH,Lum FM,Ghaffar K,Chan YH,Amrun SN,Tan JJL,Lee CYP,Chua TK,Carissimo G,Lee WWL,Claser C,Rajarethinam R,Rénia L,Ng LFP
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Tue Sep 25 00:00:00 EDT 2018
TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival.
Nature communications
Zhu L,Xie X,Zhang L,Wang H,Jie Z,Zhou X,Shi J,Zhao S,Zhang B,Cheng X,Sun SC
14-5941 was used in Flow cytometry/Cell sorting to study the mechanism of IL-15 function in autophagy and natural killer cell survival.
Wed Jul 18 00:00:00 EDT 2018
Inhibiting Glycogen Synthase Kinase 3 Reverses Obesity-Induced White Adipose Tissue Inflammation by Regulating Apoptosis Inhibitor of Macrophage/CD5L-Mediated Macrophage Migration.
Arteriosclerosis, thrombosis, and vascular biology
Wang L,Wang Y,Zhang C,Li J,Meng Y,Dou M,Noguchi CT,Di L
14-5941-82 was used in Flow cytometry/Cell sorting to examine the potential mechanism by which GSK3 in modulating obesity-induced visceral adipose tissue (VAT) inflammation.
Sat Sep 01 00:00:00 EDT 2018
A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.
Nature communications
Guarnerio J,Mendez LM,Asada N,Menon AV,Fung J,Berry K,Frenette PS,Ito K,Pandolfi PP
14-5941 was used in Flow cytometry/Cell sorting to show Pml in mesenchymal stem cells regulate pro-inflammatory cytokines which may sustain leukemic cells.
Thu Jan 04 00:00:00 EST 2018
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.
Nature immunology
Shan Q,Zeng Z,Xing S,Li F,Hartwig SM,Gullicksrud JA,Kurup SP,Van Braeckel-Budimir N,Su Y,Martin MD,Varga SM,Taniuchi I,Harty JT,Peng W,Badovinac VP,Xue HH
14-5941 was used in Flow cytometry/Cell sorting to show that Runx3-mediated Tcf7 repression coordinately enforced acquisition of cytotoxic functions and protected the cytotoxic lineage integrity by preventing TFH-lineage deviation.
Tue Aug 01 00:00:00 EDT 2017
Differentiation of human and murine induced pluripotent stem cells to microglia-like cells.
Nature neuroscience
Pandya H,Shen MJ,Ichikawa DM,Sedlock AB,Choi Y,Johnson KR,Kim G,Brown MA,Elkahloun AG,Maric D,Sweeney CL,Gossa S,Malech HL,McGavern DB,Park JK
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Mon May 01 00:00:00 EDT 2017
Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma.
The Journal of experimental medicine
Takahashi T,Asano Y,Sugawara K,Yamashita T,Nakamura K,Saigusa R,Ichimura Y,Toyama T,Taniguchi T,Akamata K,Noda S,Yoshizaki A,Tsuruta D,Trojanowska M,Sato S
14594182 was used in flow cytometry to explore the contribution of epithelial cells to systemic sclerosis pathogenesis
Mon Apr 03 00:00:00 EDT 2017
Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity.
The Journal of experimental medicine
Chen S,Cai C,Li Z,Liu G,Wang Y,Blonska M,Li D,Du J,Lin X,Yang M,Dong Z
14-5941-82 was used in Flow Cytometry to examine NKT cell development and humoral immunity in mice completely deficient in SFR.
Wed Feb 01 00:00:00 EST 2017
A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells.
Leukemia
Cheadle EJ,Lipowska-Bhalla G,Dovedi SJ,Fagnano E,Klein C,Honeychurch J,Illidge TM
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Sat Jul 01 00:00:00 EDT 2017
NK-Cell Recruitment Is Necessary for Eradication of Peritoneal Carcinomatosis with an IL12-Expressing Maraba Virus Cellular Vaccine.
Cancer immunology research
Alkayyal AA,Tai LH,Kennedy MA,de Souza CT,Zhang J,Lefebvre C,Sahi S,Ananth AA,Mahmoud AB,Makrigiannis AP,Cron GO,Macdonald B,Marginean EC,Stojdl DF,Bell JC,Auer RC
14-5941 was used in Flow cytometry/Cell sorting to suggest that an MG1-IL12-ICV is a promising therapy that could provide benefit to the thousands of patients diagnosed with PC each year.
Wed Mar 01 00:00:00 EST 2017
A non-canonical function of Ezh2 preserves immune homeostasis.
EMBO reports
Vasanthakumar A,Xu D,Lun AT,Kueh AJ,van Gisbergen KP,Iannarella N,Li X,Yu L,Wang D,Williams BR,Lee SC,Majewski IJ,Godfrey DI,Smyth GK,Alexander WS,Herold MJ,Kallies A,Nutt SL,Allan RS
14-5941 was used in Flow cytometry/Cell sorting to identify a chromatin-independent function of enhancer of zeste 2 that impacts on the development of the immune system.
Sat Apr 01 00:00:00 EDT 2017
Mycobacterium tuberculosis infection modulates adipose tissue biology.
PLoS pathogens
Beigier-Bompadre M,Montagna GN,Kühl AA,Lozza L,Weiner J,Kupz A,Vogelzang A,Mollenkopf HJ,Löwe D,Bandermann S,Dorhoi A,Brinkmann V,Matuschewski K,Kaufmann SHE
14-5941 was used in Flow cytometry/Cell sorting to conclude that adipose tissue is a potential niche for Mtb and that due to infection CD8+ T cells and NK cells are attracted to this tissue.
Sun Oct 01 00:00:00 EDT 2017
IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury.
Frontiers in neurology
Gao W,Li F,Zhou Z,Xu X,Wu Y,Zhou S,Yin D,Sun D,Xiong J,Jiang R,Zhang J
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis.
Nature communications
Krzywinska E,Kantari-Mimoun C,Kerdiles Y,Sobecki M,Isagawa T,Gotthardt D,Castells M,Haubold J,Millien C,Viel T,Tavitian B,Takeda N,Fandrey J,Vivier E,Sexl V,Stockmann C
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Fri Nov 17 00:00:00 EST 2017
Alternative activation generates IL-10 producing type 2 innate lymphoid cells.
Nature communications
Seehus CR,Kadavallore A,Torre B,Yeckes AR,Wang Y,Tang J,Kaye J
14-5941 was used in Flow Cytometry to demonstrate the generation of a previously unappreciated IL-10 producing type 2 innate lymphoid cell effector cell population.
Fri Dec 01 00:00:00 EST 2017
A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages.
eLife
Morales AJ,Carrero JA,Hung PJ,Tubbs AT,Andrews JM,Edelson BT,Calderon B,Innes CL,Paules RS,Payton JE,Sleckman BP
14-5941 was used in Flow cytometry/Cell sorting to investigate the role of genotoxic agents produced by macrophages in inflammasome activation.
Fri Mar 31 00:00:00 EDT 2017
Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis.
PloS one
Tornack J,Reece ST,Bauer WM,Vogelzang A,Bandermann S,Zedler U,Stingl G,Kaufmann SH,Melchers F
14-5941-82 was used in Flow Cytometry to conclude that LT-pHSCs, together with MSCs of Mtb-infected humans and mice serve as a hitherto unappreciated quiescent cellular depot for Mtb during latent TB infection.
Tue Sep 05 00:00:00 EDT 2017
A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.
Nature genetics
Jabara HH,Boyden SE,Chou J,Ramesh N,Massaad MJ,Benson H,Bainter W,Fraulino D,Rahimov F,Sieff C,Liu ZJ,Alshemmari SH,Al-Ramadi BK,Al-Dhekri H,Arnaout R,Abu-Shukair M,Vatsayan A,Silver E,Ahuja S,Davies EG,Sola-Visner M,Ohsumi TK,Andrews NC,Notarangelo LD,Fleming MD,Al-Herz W,Kunkel LM,Geha RS
14-5941 was used in Flow cytometry/Cell sorting to demonstrate the importance of TfR1 in adaptive immunity.
Fri Jan 01 00:00:00 EST 2016
Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.
Nature immunology
Monticelli LA,Buck MD,Flamar AL,Saenz SA,Tait Wojno ED,Yudanin NA,Osborne LC,Hepworth MR,Tran SV,Rodewald HR,Shah H,Cross JR,Diamond JM,Cantu E,Christie JD,Pearce EL,Artis D
14-5941 was used in Flow cytometry/Cell sorting to identify Arg1 as a key regulator of group 2 innate lymphoid cell bioenergetics that control proliferative capacity and pro-inflammatory functions.
Wed Jun 01 00:00:00 EDT 2016
Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.
Circulation research
Sager HB,Hulsmans M,Lavine KJ,Moreira MB,Heidt T,Courties G,Sun Y,Iwamoto Y,Tricot B,Khan OF,Dahlman JE,Borodovsky A,Fitzgerald K,Anderson DG,Weissleder R,Libby P,Swirski FK,Nahrendorf M
14-5941 was used in Flow cytometry/Cell sorting to elucidate the origin and roles of macrophages in the post-myocardial infarction remodelling of nonischaemic remote myocardium.
Fri Sep 16 00:00:00 EDT 2016
The breast tumor microenvironment alters the phenotype and function of natural killer cells.
Cellular & molecular immunology
Krneta T,Gillgrass A,Chew M,Ashkar AA
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Thu Sep 01 00:00:00 EDT 2016
Hypoxia-Inducible Factor-2α Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury.
Journal of the American Society of Nephrology : JASN
Zhang J,Han C,Dai H,Hou J,Dong Y,Cui X,Xu L,Zhang M,Xia Q
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
TNF and CD28 Signaling Play Unique but Complementary Roles in the Systemic Recruitment of Innate Immune Cells after Staphylococcus aureus Enterotoxin A Inhalation.
Journal of immunology (Baltimore, Md. : 1950)
Svedova J,Tsurutani N,Liu W,Khanna KM,Vella AT
14-5941 was used in Flow cytometry/Cell sorting to investigate how Staphylococcus aureus enterotoxins spread systemically and trigger inflammatory cascades.
Wed Jun 01 00:00:00 EDT 2016
NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation.
Nature communications
Yang M,Chen S,Du J,He J,Wang Y,Li Z,Liu G,Peng W,Zeng X,Li D,Xu P,Guo W,Chang Z,Wang S,Tian Z,Dong Z
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Wed Sep 07 00:00:00 EDT 2016
Independent control of natural killer cell responsiveness and homeostasis at steady-state by CD11c+ dendritic cells.
Scientific reports
Luu TT,Ganesan S,Wagner AK,Sarhan D,Meinke S,Garbi N,Hämmerling G,Alici E,Kärre K,Chambers BJ,Höglund P,Kadri N
14-5941 was used in Flow cytometry/Cell sorting to study the effect of DC depletion on resting NK cell function.
Thu Dec 01 00:00:00 EST 2016
CRISPR-Mediated Triple Knockout of SLAMF1, SLAMF5 and SLAMF6 Supports Positive Signaling Roles in NKT Cell Development.
PloS one
Huang B,Gomez-Rodriguez J,Preite S,Garrett LJ,Harper UL,Schwartzberg PL
14-5941 was used in Flow cytometry/Cell sorting to elucidate the contribution of the SLAM receptors in immunodysregulation observed in X-linked lymphoproliferative syndrome Type 1.
Mon Jul 24 00:00:00 EDT 2017
Stat3 Signaling Promotes Survival And Maintenance Of Medullary Thymic Epithelial Cells.
PLoS genetics
Lomada D,Jain M,Bolner M,Reeh KA,Kang R,Reddy MC,DiGiovanni J,Richie ER
14-5941 was used in Flow cytometry/Cell sorting to demonstrate that in addition to the NFkB pathway, Stat3-mediated signals play an essential role in regulating mTEC cellularity and medullary region homeostasis.
Fri Jan 01 00:00:00 EST 2016
Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage.
The Journal of experimental medicine
Aparicio-Domingo P,Romera-Hernandez M,Karrich JJ,Cornelissen F,Papazian N,Lindenbergh-Kortleve DJ,Butler JA,Boon L,Coles MC,Samsom JN,Cupedo T
14-5941 was used in Flow cytometry/Cell sorting to investigate the cellular mechanisms that control tissue protection and mucosal healing in response to intestinal damage.
Mon Oct 19 00:00:00 EDT 2015
Nonblocking Monoclonal Antibody Targeting Soluble MIC Revamps Endogenous Innate and Adaptive Antitumor Responses and Eliminates Primary and Metastatic Tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research
Lu S,Zhang J,Liu D,Li G,Staveley-O'Carroll KF,Li Z,Wu JD
14-5941-82 was used in Flow Cytometry to evaluate the therapeutic effect of a monoclonal antibody targeting soluble MHC I-chain-related molecule in a clinically relevant transgenic animal model.
Sun Nov 01 00:00:00 EDT 2015
Tumor-derived inducible heat-shock protein 70 (HSP70) is an essential component of anti-tumor immunity.
Oncogene
Dodd K,Nance S,Quezada M,Janke L,Morrison JB,Williams RT,Beere HM
14-5941 was used in Immunohistochemistry on frozen tissues to support a role for tumor-derived HSP70 in facilitating anti-tumor immunity to limit tumor growth.
Thu Mar 05 00:00:00 EST 2015
Peptide-MHC-I from Endogenous Antigen Outnumber Those from Exogenous Antigen, Irrespective of APC Phenotype or Activation.
PLoS pathogens
Sei JJ,Haskett S,Kaminsky LW,Lin E,Truckenmiller ME,Bellone CJ,Buller RM,Norbury CC
14-5941 was used in Flow cytometry/Cell sorting to suggest that direct antigen presentation is the dominant pathway in mice during mousepox.
Mon Jun 01 00:00:00 EDT 2015
Activated NKT cells imprint NK-cell differentiation, functionality and education.
European journal of immunology
Riese P,Trittel S,May T,Cicin-Sain L,Chambers BJ,Guzmán CA
14-5941-82 was used in Flow Cytometry to study the cellular cross-talk between natural killer T cells and natural killer cells.
Mon Jun 01 00:00:00 EDT 2015
Anti-herpes Activity of Vinegar-processed Daphne genkwa Flos Via Enhancement of Natural Killer Cell Activity.
Immune network
Uyangaa E,Choi JY,Ryu HW,Oh SR,Eo SK
14-5941 was used in Flow cytometry/Cell sorting to demonstrate that enhanced resistance to HSV-1 infection by treatment with vp-genkwa is associated with NK cell activation.
Wed Apr 01 00:00:00 EDT 2015
Cutting edge: NF-κB p65 and c-Rel control epidermal development and immune homeostasis in the skin.
Journal of immunology (Baltimore, Md. : 1950)
Grinberg-Bleyer Y,Dainichi T,Oh H,Heise N,Klein U,Schmid RM,Hayden MS,Ghosh S
14-5941-82 was used in Flow Cytometry to analyse the function of canonical NF-κB in the epidermis using CRE-mediated deletion of p65 and c-Rel in keratinocytes.
Sun Mar 15 00:00:00 EDT 2015
IL-15 Superagonist-Mediated Immunotoxicity: Role of NK Cells and IFN-γ.
Journal of immunology (Baltimore, Md. : 1950)
Guo Y,Luan L,Rabacal W,Bohannon JK,Fensterheim BA,Hernandez A,Sherwood ER
14-5941 was used in Neutralization experiments to investigate the effect of IL-15 SA on physiologic and immunologic functions of mice.
Tue Sep 01 00:00:00 EDT 2015
SHIP1 intrinsically regulates NK cell signaling and education, resulting in tolerance of an MHC class I-mismatched bone marrow graft in mice.
Journal of immunology (Baltimore, Md. : 1950)
Gumbleton M,Vivier E,Kerr WG
14-5941 was used in Flow cytometry/Cell sorting to define the intracellular molecular events that culminate in tolerance and functional competency of educated NK cells.
Sun Mar 15 00:00:00 EDT 2015
Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.
PloS one
Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Thu Apr 28 00:00:00 EDT 2016
Metronomic cyclophosphamide eradicates large implanted GL261 gliomas by activating antitumor Cd8+ T-cell responses and immune memory.
Oncoimmunology
Wu J,Waxman DJ
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2015
Mechanisms of immunity in post-exposure vaccination against Ebola virus infection.
PloS one
Bradfute SB,Anthony SM,Stuthman KS,Ayithan N,Tailor P,Shaia CI,Bray M,Ozato K,Bavari S
14-5941 was used in Functional assays to analyse the expression levels of various cytokines in the serum of mice given an Ebola virus-like particle.
Tue Feb 23 00:00:00 EST 2016
DNAM-1 expression marks an alternative program of NK cell maturation.
Cell reports
Martinet L,Ferrari De Andrade L,Guillerey C,Lee JS,Liu J,Souza-Fonseca-Guimaraes F,Hutchinson DS,Kolesnik TB,Nicholson SE,Huntington ND,Smyth MJ
14-5941 was used in Flow cytometry/Cell sorting to reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.
Tue Apr 07 00:00:00 EDT 2015
Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint.
PloS one
Tamehiro N,Oda H,Shirai M,Suzuki H
14-5941 was used in Flow cytometry/Cell sorting to indicate that an excess amount of RhoH is able to initiate pre-TCR signalling in the absence of pre-TCR complexes.
Mon Apr 25 00:00:00 EDT 2016
Vitamin D deficiency decreases survival of bacterial meningoencephalitis in mice.
Journal of neuroinflammation
Djukic M,Sostmann N,Bertsch T,Mecke M,Nessler S,Manig A,Hanisch UK,Triebel J,Bollheimer LC,Sieber C,Nau R
14-5941 was used in Flow cytometry/Cell sorting to suggest a detrimental role of vitamin D deficiency in bacterial central nervous system infections.
Wed Jan 07 00:00:00 EST 2015
Deficient Natural Killer Dendritic Cell Responses Underlay the Induction of Theiler's Virus-Induced Autoimmunity.
mBio
Chastain EM,Getts DR,Miller SD
14-5941 was used in Flow cytometry/Cell sorting to determine that disease-susceptible SJL/J mice lacked a unique innate immune population, which plays a role in early CNS virus clearance.
Tue Aug 04 00:00:00 EDT 2015
Anti-Inflammatory Effects of IL-27 in Zymosan-Induced Peritonitis: Inhibition of Neutrophil Recruitment Partially Explained by Impaired Mobilization from Bone Marrow and Reduced Chemokine Levels.
PloS one
Watzlawick R,Kenngott EE,Liu FD,Schwab JM,Hamann A
14-5941 was used in Flow cytometry/Cell sorting to determine the role of IL-27 in innate immune responses.
Tue May 24 00:00:00 EDT 2016
Depletion of B220+NK1.1+ cells enhances the rejection of established melanoma by tumor-specific CD4+ T cells.
Oncoimmunology
Wilson KA,Goding SR,Neely HR,Harris KM,Antony PA
14-5941 was used in Flow cytometry/Cell sorting to show that interferon-producing killer dendritic cells are an important inhibitor of the CD4(+) T cell response to melanoma.
Sat Aug 01 00:00:00 EDT 2015
A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.
Nature medicine
Herranz D,Ambesi-Impiombato A,Palomero T,Schnell SA,Belver L,Wendorff AA,Xu L,Castillo-Martin M,Llobet-Navás D,Cordon-Cardo C,Clappier E,Soulier J,Ferrando AA
14-5941 was used in Flow cytometry/Cell sorting to identify N-Me as a long-range oncogenic enhancer implicated directly in the pathogenesis of human leukaemia.
Wed Oct 01 00:00:00 EDT 2014
α-1-Antitrypsin (AAT)-modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics.
Blood
Marcondes AM,Karoopongse E,Lesnikova M,Margineantu D,Welte T,Dinarello CA,Hockenbery D,Janciauskiene S,Deeg HJ
14-5941 was used in Flow cytometry/Cell sorting to investigate the role of α-1-antitrypsin in graft-versus-host disease, showing that α-1-Antitrypsin-modified donor cells suppress graft-versus-host disease but enhance the graft-versus-leukemia effect.
Thu Oct 30 00:00:00 EDT 2014
The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.
The Journal of experimental medicine
Male V,Nisoli I,Kostrzewski T,Allan DS,Carlyle JR,Lord GM,Wack A,Brady HJ
14-5941 was used in Flow cytometry/Cell sorting to propose that E4bp4 is required for commitment to the NK lineage and can promote NK development by directly regulating the expression of the downstream transcription factors Eomes and Id2.
Mon Apr 07 00:00:00 EDT 2014
Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination.
Proceedings of the National Academy of Sciences of the United States of America
Rashkovan M,Vadnais C,Ross J,Gigoux M,Suh WK,Gu W,Kosan C,Möröy T
14-5941 was used in Flow cytometry/Cell sorting to show how the protein Miz-1 restricts p53-dependent apoptosis in pro-B and pre-T cells actively rearranging antigen receptor genes.
Tue Dec 16 00:00:00 EST 2014
The Critical Role of IL-15-PI3K-mTOR Pathway in Natural Killer Cell Effector Functions.
Frontiers in immunology
Nandagopal N,Ali AK,Komal AK,Lee SH
14-5941 was used in Flow cytometry/Cell sorting to investigate whether the effect of IL-15 priming of NK cells can be extended to other cytokines, showing a critical role of the IL-15-PI3K-mTOR in NK effector functions.
Mon May 05 00:00:00 EDT 2014
Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells.
Mucosal immunology
Chan IH,Jain R,Tessmer MS,Gorman D,Mangadu R,Sathe M,Vives F,Moon C,Penaflor E,Turner S,Ayanoglu G,Chang C,Basham B,Mumm JB,Pierce RH,Yearley JH,McClanahan TK,Phillips JH,Cua DJ,Bowman EP,Kastelein RA,LaFace D
14-5941 was used in Flow cytometry/Cell sorting to reveal an explicit role for IL-23-mediated initiation of gut tumorigenesis and implicate a key role for IL-23R(+) ILC3 in the absence of overt cellular infiltrate recruitment.
Tue Jul 01 00:00:00 EDT 2014
Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection.
PLoS pathogens
Whitney PG,Bär E,Osorio F,Rogers NC,Schraml BU,Deddouche S,LeibundGut-Landmann S,Reis e Sousa C
14-5941 was used in Flow cytometry/Cell sorting to study the contribution of a specific signalling pathway involved in fungal recognition by dendritic cells during immune responses to fungal pathogens.
Tue Jul 01 00:00:00 EDT 2014
Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection.
PLoS pathogens
Whitney PG,Bär E,Osorio F,Rogers NC,Schraml BU,Deddouche S,LeibundGut-Landmann S,Reis e Sousa C
14-5941 was used in Flow cytometry/Cell sorting to study the contribution of a specific signalling pathway involved in fungal recognition by dendritic cells during immune responses to fungal pathogens.
Tue Jul 01 00:00:00 EDT 2014
Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii.
Immunology and cell biology
Han SJ,Melichar HJ,Coombes JL,Chan SW,Koshy AA,Boothroyd JC,Barton GM,Robey EA
14-5941 was used in Flow cytometry/Cell sorting to show that inflammatory monocytes, but not neutrophils, produce IFN-β in response to T. gondii infection.
Sat Nov 01 00:00:00 EDT 2014
Cutting edge: CD8+ recent thymic emigrants exhibit increased responses to low-affinity ligands and improved access to peripheral sites of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Berkley AM,Fink PJ
14-5941-82 was used in Flow Cytometry to investigate if the maturation state of peripheral T cells impacts the response to bacterial infection due to intrinsic differences in TCR signaling.
Wed Oct 01 00:00:00 EDT 2014
Innate immune cell CD45 regulates lymphopenia-induced T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Saunders AE,Shim YA,Johnson P
14-5941 was used in Flow cytometry/Cell sorting to demonstrate a novel role for CD45 on innate immune cells in promoting lymphopenia-induced T cell proliferation.
Mon Sep 15 00:00:00 EDT 2014
Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface.
PloS one
Habbeddine M,Verbeke P,Karaz S,Bobé P,Kanellopoulos-Langevin C
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Wed Jun 10 00:00:00 EDT 2015
A flagellin-derived toll-like receptor 5 agonist stimulates cytotoxic lymphocyte-mediated tumor immunity.
PloS one
Leigh ND,Bian G,Ding X,Liu H,Aygun-Sunar S,Burdelya LG,Gudkov AV,Cao X
14-5941 was used in Flow cytometry/Cell sorting to assess the immunogenic capabilities of CBLB502, a toll-like receptor 5 agonist.
Wed Sep 17 00:00:00 EDT 2014
Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.
PloS one
May SL,Zhou Q,Lewellen M,Carter CM,Coffey D,Highfill SL,Bucher CM,Matise I,Morse HC,O'Sullivan MG,Schutten M,Johnson C,Bellgrau D,Blazar BR,Modiano JF
14-5941 was used in Magnetic cell separation to study how Nfatc2 and Tob1 are non-redundant regulators of lymphocyte homeostasis.
Mon Oct 19 00:00:00 EDT 2015
Intraperitoneal prophylaxis with CpG oligodeoxynucleotides protects neutropenic mice against intracerebral Escherichia coli K1 infection.
Journal of neuroinflammation
Ribes S,Meister T,Ott M,Redlich S,Janova H,Hanisch UK,Nessler S,Nau R
14-5941 was used in Flow cytometry/Cell sorting to suggest that systemic administration of CpG ODN may help to prevent bacterial CNS infections in immunocompromised individuals.
Thu Jan 23 00:00:00 EST 2014
Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection.
Cell host & microbe
Jordan S,Ruzsics Z,Mitrović M,Baranek T,Arapović J,Krmpotić A,Vivier E,Dalod M,Jonjić S,Dölken L,Koszinowski UH
14-5941 was used in Neutralization experiments to investigate the underlying mechanisms of extramedullary hematopoiesis.
Wed May 15 00:00:00 EDT 2013
Natural killer cells are required for extramedullary hematopoiesis following murine cytomegalovirus infection.
Cell host & microbe
Jordan S,Ruzsics Z,Mitrović M,Baranek T,Arapović J,Krmpotić A,Vivier E,Dalod M,Jonjić S,Dölken L,Koszinowski UH
14-5941 was used in Neutralization experiments to investigate the underlying mechanisms of extramedullary hematopoiesis.
Wed May 15 00:00:00 EDT 2013
Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells.
Nature immunology
Cohen NR,Brennan PJ,Shay T,Watts GF,Brigl M,Kang J,Brenner MB
14-5941 was used in Flow cytometry/Cell sorting to profile gene expression in invariant natural killer T cells during ontogeny and in peripheral subsets.
Tue Jan 01 00:00:00 EST 2013
Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100.
Blood
Leonhardt F,Grundmann S,Behe M,Bluhm F,Dumont RA,Braun F,Fani M,Riesner K,Prinz G,Hechinger AK,Gerlach UV,Dierbach H,Penack O,Schmitt-Gräff A,Finke J,Weber WA,Zeiser R
14-5941-82 was used in Flow Cytometry to identify negative regulation of GvHD-related neovascularization by miR-100.
Thu Apr 25 00:00:00 EDT 2013
Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation.
The Journal of clinical investigation
Kansara M,Leong HS,Lin DM,Popkiss S,Pang P,Garsed DW,Walkley CR,Cullinane C,Ellul J,Haynes NM,Hicks R,Kuijjer ML,Cleton-Jansen AM,Hinds PW,Smyth MJ,Thomas DM
14-5941 was used in Flow cytometry/Cell sorting to indicate that overcoming the immune response to senescence is a rate-limiting step in the formation of IR-induced osteosarcoma.
Sun Dec 01 00:00:00 EST 2013
HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.
The Journal of experimental medicine
Gautier EL,Westerterp M,Bhagwat N,Cremers S,Shih A,Abdel-Wahab O,Lütjohann D,Randolph GJ,Levine RL,Tall AR,Yvan-Charvet L
14-5941 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms leading to high metabolic rate in myeloproliferative disorders, showing that HDL and Glut1 inhibition reverse hypermetabolic state.
Mon Feb 11 00:00:00 EST 2013
Epithelial cell TGFβ signaling induces acute tubular injury and interstitial inflammation.
Journal of the American Society of Nephrology : JASN
Gentle ME,Shi S,Daehn I,Zhang T,Qi H,Yu L,D'Agati VD,Schlondorff DO,Bottinger EP
14-5941 was used in Flow cytometry/Cell sorting to suggest that TGFβ signaling in the tubular epithelium alone is sufficient to cause acute tubular injury and inflammation.
Mon Apr 01 00:00:00 EDT 2013
NK cells are necessary for recovery of corneal CD11c+ dendritic cells after epithelial abrasion injury.
Journal of leukocyte biology
Gao Y,Li Z,Hassan N,Mehta P,Burns AR,Tang X,Smith CW
14-5941 was used in in vivo experiments to investigate the mechanisms controlling CD11c(+) MHCII(+) DCs during corneal epithelial wound healing.
Thu Aug 01 00:00:00 EDT 2013
Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity.
Molecular and cellular biology
Zhong MC,Veillette A
14-5941 was used in Flow cytometry/Cell sorting to explore the therapeutic potential of blocking the SLAM-associated protein (SAP) for human autoimmune diseases.
Fri Mar 01 00:00:00 EST 2013
Toll-like receptor 7 mediates early innate immune responses to malaria.
Infection and immunity
Baccarella A,Fontana MF,Chen EC,Kim CC
14-5941 was used in Flow cytometry/Cell sorting to investigate other MYD88-dependent receptors contributing to antimalarial responses, showing that toll-like receptor 7 mediates early innate immune responses to malaria.
Sun Dec 01 00:00:00 EST 2013
Cross-activating invariant NKT cells and kupffer cells suppress cholestatic liver injury in a mouse model of biliary obstruction.
PloS one
Duwaerts CC,Sun EP,Cheng CW,van Rooijen N,Gregory SH
14-5941 was used in Flow cytometry/Cell sorting to investigate whether iNKT and Kupffer cell suppression of neutrophil-dependent liver injury is interdependent, showing that cross-activation allows suppression of injury.
Fri Jul 11 00:00:00 EDT 2014
Trogocytosis as a mechanistic link between chimerism and prenatal tolerance.
Chimerism
Alhajjat AM,Strong BS,Durkin ET,Turner LE,Wadhwani RK,Midura EF,Keswani SG,Shaaban AF
14-5941 was used in Flow cytometry/Cell sorting to investigate the mechanisms leading to NK cell tolerance in prenatal chimeras, showing trogocytosis as a mechanistic link between chimerism and prenatal tolerance.
Thu Nov 06 00:00:00 EST 2014
Molecular definition of the identity and activation of natural killer cells.
Nature immunology
Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL
14-5941 was used in Flow cytometry/Cell sorting to systematically define the transcriptome of mouse natural killer cells in several contexts.
Mon Oct 01 00:00:00 EDT 2012
Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a.
Blood
Berent-Maoz B,Montecino-Rodriguez E,Signer RA,Dorshkind K
14-5941 was used in Flow cytometry/Cell sorting to define a genetic basis for thymocyte progenitor aging.
Thu Jun 14 00:00:00 EDT 2012
VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression.
Cancer research
Doloff JC,Waxman DJ
Published figure using NK1.1 monoclonal antibody (Product # 14-5941-82) in Flow Cytometry
Thu Mar 01 00:00:00 EST 2012
Reverse signaling through the costimulatory ligand CD137L in epithelial cells is essential for natural killer cell-mediated acute tissue inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Kim HJ,Lee JS,Kim JD,Cha HJ,Kim A,Lee SK,Lee SC,Kwon BS,Mittler RS,Cho HR,Kwon B
14-5941 was used in Flow cytometry/Cell sorting to determine the specific step at which CD137-CD137L interactions regulate renal ischemia-reperfusion injury-induced inflammation in a mouse model.
Tue Jan 03 00:00:00 EST 2012
c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis.
Science signaling
Piao X,Komazawa-Sakon S,Nishina T,Koike M,Piao JH,Ehlken H,Kurihara H,Hara M,Van Rooijen N,Schütz G,Ohmuraya M,Uchiyama Y,Yagita H,Okumura K,He YW,Nakano H
14-5941 was used in Flow cytometry/Cell sorting to investigate the role of c-Flip in postnatal intestine and liver development, showing that homeostasis is maintained by inhibiting apoptosis and programmed necrosis.
Tue Dec 18 00:00:00 EST 2012
Differential effects of stimulatory factors on natural killer cell activities of young and aged mice.
The journals of gerontology. Series A, Biological sciences and medical sciences
Nogusa S,Murasko DM,Gardner EM
14-5941 was used in Flow cytometry/Cell sorting to demonstrate the differential response of natural killer cells from young and aged mice to cytokine stimulation.
Sat Sep 01 00:00:00 EDT 2012
Protein kinase C-θ clustering at immunological synapses amplifies effector responses in NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Merino E,Abeyweera TP,Firth MA,Zawislak CL,Basu R,Liu X,Sun JC,Huse M
14-5941 was used in Functional assays to study the role of compartmentalised PKC signalling in natural killer cell activation.
Thu Nov 15 00:00:00 EST 2012
Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses.
Infection and immunity
Kanistanon D,Powell DA,Hajjar AM,Pelletier MR,Cohen IE,Way SS,Skerrett SJ,Wang X,Raetz CR,Ernst RK
14-5941 was used in Flow cytometry/Cell sorting to study the pathogenic effects of LPS modifications at the lipid A component of a Francisella novicida mutant.
Thu Mar 01 00:00:00 EST 2012
CCR2 defines a distinct population of NK cells and mediates their migration during influenza virus infection in mice.
PloS one
van Helden MJ,Zaiss DM,Sijts AJ
14-5941 was used in Flow cytometry/Cell sorting to determine the role of CCR2 in NK cell migration during intranasal influenza virus infection, showing that it defines a distinct population of NK cells and mediates their migration.
Mon Jun 10 00:00:00 EDT 2013
NK cells suppress experimental cholestatic liver injury by an interleukin-6-mediated, Kupffer cell-dependent mechanism.
Journal of hepatology
Cheng CW,Duwaerts CC,Rooijen Nv,Wintermeyer P,Mott S,Gregory SH
14-5941 was used in Flow cytometry/Cell sorting to investigate the response of NK cells to liver injury that occurs in a mouse model of biliary obstruction.
Fri Apr 01 00:00:00 EDT 2011
Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking.
Blood
Mayol K,Biajoux V,Marvel J,Balabanian K,Walzer T
14-5941 was used in Flow cytometry/Cell sorting to investigate the role of CXCR4 and S1P5 in natural killer cell trafficking.
Thu Nov 03 00:00:00 EDT 2011
Recent thymic emigrants are biased against the T-helper type 1 and toward the T-helper type 2 effector lineage.
Blood
Hendricks DW,Fink PJ
14-5941 was used in Flow cytometry/Cell sorting to investigate the relationships between recent thymic emigrants and T-helper type 1 and 2 cells.
Thu Jan 27 00:00:00 EST 2011
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.
The Journal of experimental medicine
Wang L,Rubinstein R,Lines JL,Wasiuk A,Ahonen C,Guo Y,Lu LF,Gondek D,Wang Y,Fava RA,Fiser A,Almo S,Noelle RJ
14-5941 was used in Flow cytometry/Cell sorting to show that VISTA has functional activities that are nonredundant with other Ig superfamily members and may play a role in the development of autoimmunity.
Mon Mar 14 00:00:00 EDT 2011
CD11b⁺, Ly6G⁺ cells produce type I interferon and exhibit tissue protective properties following peripheral virus infection.
PLoS pathogens
Fischer MA,Davies ML,Reider IE,Heipertz EL,Epler MR,Sei JJ,Ingersoll MA,Rooijen NV,Randolph GJ,Norbury CC
14-5941 was used in Flow cytometry/Cell sorting to demonstrate that innate immune effector cells contain a peripheral poxvirus infection, preventing systemic spread of the virus.
Tue Nov 01 00:00:00 EDT 2011
Genetic labeling reveals altered turnover and stability of innate lymphocytes in latent mouse cytomegalovirus infection.
Journal of immunology (Baltimore, Md. : 1950)
Busche A,Schmitz S,Fleige H,Robbins SH,Walzer T,Stewart CA,Förster R,Messerle M,Prinz I
14-5941 was used in Flow cytometry/Cell sorting to determine that antiviral immune responses may induce sustained alterations in natural killer cell populations.
Tue Mar 01 00:00:00 EST 2011
Bioluminescent imaging reveals divergent viral pathogenesis in two strains of Stat1-deficient mice, and in αßγ interferon receptor-deficient mice.
PloS one
Pasieka TJ,Collins L,O'Connor MA,Chen Y,Parker ZM,Berwin BL,Piwnica-Worms DR,Leib DA
14-5941 was used in Flow cytometry/Cell sorting to examine HSV-1 pathogenesis in Stat1(-/-) mice and in IFNαβγR(-/-) mice, showing divergent viral pathogenesis between mouse strains.
Tue Feb 14 00:00:00 EST 2012
FTY720 reduces post-ischemic brain lymphocyte influx but does not improve outcome in permanent murine cerebral ischemia.
PloS one
Liesz A,Sun L,Zhou W,Schwarting S,Mracsko E,Zorn M,Bauer H,Sommer C,Veltkamp R
14-5941 was used in Flow cytometry/Cell sorting to detect a reduction of lymphocyte brain invasion by FTY720.
Fri Oct 14 00:00:00 EDT 2011
Induction of anti-glioma natural killer cell response following multiple low-dose intracerebral CpG therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Alizadeh D,Zhang L,Brown CE,Farrukh O,Jensen MC,Badie B
14-5941 was used in Flow cytometry/Cell sorting to suggest that multiple low-dose intratumoral injections of CpG-ODN can eradicate intracranial gliomas, potentially through mechanisms involving NK-mediated effector function.
Thu Jul 01 00:00:00 EDT 2010
Notch dimerization is required for leukemogenesis and T-cell development.
Genes & development
Liu H,Chi AW,Arnett KL,Chiang MY,Xu L,Shestova O,Wang H,Li YM,Bhandoola A,Aster JC,Blacklow SC,Pear WS
14-5941 was used in Flow cytometry/Cell sorting to show that dimeric Notch transcriptional complexes are required for T-cell maturation and leukemic transformation but are dispensable for T-cell fate specification from a multipotential precursor.
Mon Nov 01 00:00:00 EDT 2010
Direct TLR2 signaling is critical for NK cell activation and function in response to vaccinia viral infection.
PLoS pathogens
Martinez J,Huang X,Yang Y
14-5941 was used in in vivo experiments to study the mechanisms underlying natural killer cell function in response to poxviruses.
Fri Mar 12 00:00:00 EST 2010
T-bet and eomesodermin are required for T cell-mediated antitumor immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Zhu Y,Ju S,Chen E,Dai S,Li C,Morel P,Liu L,Zhang X,Lu B
14-5941 was used in Flow cytometry/Cell sorting to define T-bet and Eomes as critical regulators of T cell-mediated immune responses against tumours.
Wed Sep 15 00:00:00 EDT 2010
Chronic cigarette smoke exposure primes NK cell activation in a mouse model of chronic obstructive pulmonary disease.
Journal of immunology (Baltimore, Md. : 1950)
Motz GT,Eppert BL,Wortham BW,Amos-Kroohs RM,Flury JL,Wesselkamper SC,Borchers MT
14-5941 was used in Flow cytometry/Cell sorting to demonstrate an entirely novel mechanism of NK cell activation resulting from chronic cigarette smoke exposure.
Thu Apr 15 00:00:00 EDT 2010
Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment.
Blood
Swee LK,Bosco N,Malissen B,Ceredig R,Rolink A
14-5941 was used in Flow cytometry/Cell sorting to show unique aspects in the regulation of Treg homeostasis by DCs and reinforce the relevance of FLT3L treatment in GVHD.
Thu Jun 18 00:00:00 EDT 2009
Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection.
The Journal of experimental medicine
Orr MT,Sun JC,Hesslein DG,Arase H,Phillips JH,Takai T,Lanier LL
14-5941 was used in Western Blotting to demonstrate that optimal NK cell-mediated immunity to MCMV depends on Ly49H signalling through both DAP10 and DAP12.
Mon Apr 13 00:00:00 EDT 2009
In vivo expression of signaling proteins in reconstituted NK cells.
Journal of immunological methods
Orr SJ,Quigley L,McVicar DW
14-5941 was used in Flow cytometry/Cell sorting to develop a novel technique to generate NK cells in vivo, all of which express a gene of interest.
Fri Jan 30 00:00:00 EST 2009
NK cell-activating receptors require PKC-theta for sustained signaling, transcriptional activation, and IFN-gamma secretion.
Blood
Tassi I,Cella M,Presti R,Colucci A,Gilfillan S,Littman DR,Colonna M
14-5941 was used in Functional assays to indicate that NK cell-activating receptors require protein kinase-C to generate sustained intracellular signals that promote transcriptional activation, inducing IFN-gamma production.
Sat Nov 15 00:00:00 EST 2008
Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus.
The Journal of experimental medicine
Iijima N,Linehan MM,Zamora M,Butkus D,Dunn R,Kehry MR,Laufer TM,Iwasaki A
14-5941 was used in Neutralization experiments to investigate the antiviral mechanism of Th1, showing that dendritic cells and B cells maximise mucosal Th1 memory response to herpes simplex virus.
Mon Dec 22 00:00:00 EST 2008
Unique receptor repertoire in mouse uterine NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Yadi H,Burke S,Madeja Z,Hemberger M,Moffett A,Colucci F
14-5941-82 was used in Flow Cytometry to define the receptor repertoire and phenotype of uterine NK cells at mid-gestation in mice.
Sat Nov 01 00:00:00 EDT 2008
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid.
The Journal of experimental medicine
Sun CM,Hall JA,Blank RB,Bouladoux N,Oukka M,Mora JR,Belkaid Y
14-5941 was used in Flow cytometry/Cell sorting to investigate how the intestinal immune system has evolved a self-contained strategy to promote T reg cell neoconversion.
Mon Aug 06 00:00:00 EDT 2007
Novel animal models for Sjögren's syndrome: expression and transfer of salivary gland dysfunction from regulatory T cell-deficient mice.
Journal of autoimmunity
Sharma R,Zheng L,Guo X,Fu SM,Ju ST,Jarjour WN
14-5941 was used in Flow cytometry/Cell sorting to investigate whether salivary and lacrimal glands are targeted in IL-2 knockout, IL-2Ralpha KO and scurfy mice.
Fri Dec 01 00:00:00 EST 2006
