Product References
Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells.
Nature communications
Rožmanić C,Lisnić B,Pribanić Matešić M,Mihalić A,Hiršl L,Park E,Lesac Brizić A,Indenbirken D,Viduka I,Šantić M,Adler B,Yokoyama WM,Krmpotić A,Juranić Lisnić V,Jonjić S,Brizić I
Published figure using CD49b (Integrin alpha 2) monoclonal antibody (Product # 12-5971-82) in Flow Cytometry
Thu Oct 12 00:00:00 EDT 2023
Mesenchymal stromal cells equipped by IFNα empower T cells with potent anti-tumor immunity.
Oncogene
Zhang T,Wang Y,Li Q,Lin L,Xu C,Xue Y,Hu M,Shi Y,Wang Y
12-5971-82 was used in Flow Cytometry to conclude that IFNα-MSCs represent a novel tumor immunotherapy strategy, especially when combined with PD-L1 blockade.
Tue Mar 01 00:00:00 EST 2022
PRMT5 Deficiency Enforces the Transcriptional and Epigenetic Programs of Klrg1+CD8+ Terminal Effector T Cells and Promotes Cancer Development.
Journal of immunology (Baltimore, Md. : 1950)
Zheng Y,Chen Z,Zhou B,Chen S,Han L,Chen N,Ma Y,Xie G,Yang J,Nie H,Shen L
12-5971-82 was used in Flow cytometry/Cell sorting to validate the importance of targeting PRMT5 in tumor treatment, because PRMT5 deficiency enforced Klrg1+ terminal CD8+ T cell development and eliminated antitumor activity.
Sat Jan 15 00:00:00 EST 2022
Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells.
The Journal of experimental medicine
Hosokawa H,Koizumi M,Masuhara K,Romero-Wolf M,Tanaka T,Nakayama T,Rothenberg EV
Published figure using CD49b (Integrin alpha 2) monoclonal antibody (Product # 12-5971-82) in Flow Cytometry
Mon Aug 02 00:00:00 EDT 2021
The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude.
The Journal of experimental medicine
Li ZY,Morman RE,Hegermiller E,Sun M,Bartom ET,Maienschein-Cline M,Sigvardsson M,Kee BL
12-5971-82 was used in Flow Cytometry to demonstrate that ID2 sets a threshold for TCF1 during NK cell development, thus controlling the balance of immature and terminally differentiated cells that support future NK cell responses.
Mon Jun 07 00:00:00 EDT 2021
Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis.
Science signaling
Lovisa S,Fletcher-Sananikone E,Sugimoto H,Hensel J,Lahiri S,Hertig A,Taduri G,Lawson E,Dewar R,Revuelta I,Kato N,Wu CJ,Bassett RL,Putluri N,Zeisberg M,Zeisberg EM,LeBleu VS,Kalluri R
12-5971 was used in Flow cytometry/Cell sorting to demonstrate a functional role for EndMT in the response to kidney capillary endothelial injury and highlight the contribution of endothelial-epithelial cross-talk in the development of kidney fibrosis with a potential for therapeutic intervention.
Tue Jun 09 00:00:00 EDT 2020
Aicardi-Goutières syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer.
PLoS genetics
Deasy SK,Uehara R,Vodnala SK,Yang HH,Dass RA,Hu Y,Lee MP,Crouch RJ,Hunter KW
12-5971-82 was used in Flow Cytometry to highlight a potential new target for combination with immunotherapies and may contribute to a better understanding of the etiology of Aicardi-Goutières Syndrome autoimmunity.
Wed May 01 00:00:00 EDT 2019
Aicardi-Goutières syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer.
PLoS genetics
Deasy SK,Uehara R,Vodnala SK,Yang HH,Dass RA,Hu Y,Lee MP,Crouch RJ,Hunter KW
12-5971-82 was used in Flow Cytometry to highlight a potential new target for combination with immunotherapies and may contribute to a better understanding of the etiology of Aicardi-Goutières Syndrome autoimmunity.
Wed May 01 00:00:00 EDT 2019
Synergized regulation of NK cell education by NKG2A and specific Ly49 family members.
Nature communications
Zhang X,Feng J,Chen S,Yang H,Dong Z
12-5971 was used in Flow cytometry/Cell sorting to provide genetic evidence supporting that NKG2A and the inhibitory members of Ly49 family receptors synergize to regulate NK cell education.
Fri Nov 01 00:00:00 EDT 2019
The immunoproteasome-specific inhibitor ONX 0914 reverses susceptibility to acute viral myocarditis.
EMBO molecular medicine
Althof N,Goetzke CC,Kespohl M,Voss K,Heuser A,Pinkert S,Kaya Z,Klingel K,Beling A
12-5971 was used in Flow cytometry/Cell sorting to describe ONX 0914 as highly protective during severe heart disease so could show this as a potent drug for the treatment of severe virus-mediated inflammation of the heart.
Thu Feb 01 00:00:00 EST 2018
Lenalidomide and Programmed Death-1 Blockade Synergistically Enhances the Effects of Dendritic Cell Vaccination in a Model of Murine Myeloma.
Frontiers in immunology
Vo MC,Jung SH,Chu TH,Lee HJ,Lakshmi TJ,Park HS,Kim HJ,Rhee JH,Lee JJ
12-5971 was used in Flow cytometry/Cell sorting to investigate the efficacy of dendritic cell vaccination in combination with lenalidomide and PD-1 blockade in a model of murine myeloma.
Sun Jan 03 00:00:00 EST 2021
Targeting of the Yersinia pestis F1 capsular antigen by innate-like B1b cells mediates a rapid protective response against bubonic plague.
NPJ vaccines
Levy Y,Vagima Y,Tidhar A,Aftalion M,Gur D,Nili U,Chitlaru T,Zauberman A,Mamroud E
Thu Oct 01 00:00:00 EDT 2020
Silencing the CSF-1 Axis Using Nanoparticle Encapsulated siRNA Mitigates Viral and Autoimmune Myocarditis.
Frontiers in immunology
Meyer IS,Goetzke CC,Kespohl M,Sauter M,Heuser A,Eckstein V,Vornlocher HP,Anderson DG,Haas J,Meder B,Katus HA,Klingel K,Beling A,Leuschner F
12-5971 was used in Flow cytometry/Cell sorting to assess the expression of colony stimulating factor 1 in patients with myocarditis.
Tue Sep 24 00:00:00 EDT 2019
Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway.
Cell death and differentiation
Shime H,Matsumoto M,Seya T
12-5971 was used in Flow cytometry/Cell sorting to study the response of CD11b+Ly6G+ granulocytic myeloid-derived suppressor cells to polyI:C in an EL4 tumour implant model.
Wed Mar 01 00:00:00 EST 2017
Differential effect of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) on leukocyte infiltration during contact hypersensitivity responses.
PeerJ
Early M,Schroeder WG,Unnithan R,Gilchrist JM,Muller WA,Schenkel A
Mon Dec 14 00:00:00 EST 2020
Induced p53 loss in mouse luminal cells causes clonal expansion and development of mammary tumours.
Nature communications
Tao L,Xiang D,Xie Y,Bronson RT,Li Z
12-5971 was used in Flow cytometry/Cell sorting to investigate how p53 deficiency contributes to breast tumourigenesis from luminal cells.
Mon Feb 13 00:00:00 EST 2017
Mononuclear Phagocytes Are Dispensable for Cardiac Remodeling in Established Pressure-Overload Heart Failure.
PloS one
Patel B,Ismahil MA,Hamid T,Bansal SS,Prabhu SD
12-5971 was used in Flow cytometry/Cell sorting to assess for alterations in MPs.
Thu Aug 10 00:00:00 EDT 2017
The breast tumor microenvironment alters the phenotype and function of natural killer cells.
Cellular & molecular immunology
Krneta T,Gillgrass A,Chew M,Ashkar AA
Published figure using CD49b (Integrin alpha 2) monoclonal antibody (Product # 12-5971-82) in Flow Cytometry
Thu Sep 01 00:00:00 EDT 2016
Laminin 521 maintains differentiation potential of mouse and human satellite cell-derived myoblasts during long-term culture expansion.
Skeletal muscle
Penton CM,Badarinarayana V,Prisco J,Powers E,Pincus M,Allen RE,August PR
12-5971 was used in Flow cytometry/Cell sorting to demonstrate laminin 521 is a superior substrate for both short-term and long-term myogenic cell culture applications compared to other commonly utilized substrates.
Tue Dec 13 00:00:00 EST 2016
Taxanes enhance trastuzumab-mediated ADCC on tumor cells through NKG2D-mediated NK cell recognition.
Oncotarget
Di Modica M,Sfondrini L,Regondi V,Varchetta S,Oliviero B,Mariani G,Bianchi GV,Generali D,Balsari A,Triulzi T,Tagliabue E
12-5971 was used in Flow cytometry/Cell sorting to indicate that taxanes increase tumor susceptibility to ADCC by acting on tumor and NK cells.
Tue Jan 05 00:00:00 EST 2016
Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential.
PloS one
Qualai J,Li LX,Cantero J,Tarrats A,Fernández MA,Sumoy L,Rodolosse A,McSorley SJ,Genescà M
12-5971 was used in Flow cytometry/Cell sorting to find markers associated with non-conventional T cell subsets, including γδ T cells and invariant natural killer T cells.
Thu Mar 16 00:00:00 EDT 2017
LRBA is Essential for Allogeneic Responses in Bone Marrow Transplantation.
Scientific reports
Park MY,Sudan R,Srivastava N,Neelam S,Youngs C,Wang JW,Engelman RW,Kerr WG
12-5971 was used in Flow cytometry/Cell sorting to investigate the immune function of LRBA, showing that it is essential for allogenic responses in bone marrow transplantation.
Tue Nov 08 00:00:00 EST 2016
Dietary lactosucrose suppresses influenza A (H1N1) virus infection in mice.
Bioscience of microbiota, food and health
Kishino E,Takemura N,Masaki H,Ito T,Nakazawa M
12-5971 was used in Flow cytometry/Cell sorting to examine the effects of lactosucrose (4(G)-β-D-galactosylsucrose) on influenza A virus infections in mice.
Mon Nov 23 00:00:00 EST 2015
Interferon-γ-Mediated Natural Killer Cell Activation by an Aqueous Panax ginseng Extract.
Evidence-based complementary and alternative medicine : eCAM
Takeda K,Okumura K
12-5971 was used in Flow cytometry/Cell sorting to examine the effects of P. ginseng extracts on the cytotoxic activity of NK cells.
Wed Dec 09 00:00:00 EST 2015
Impaired CD8(+) T cell immunity after allogeneic bone marrow transplantation leads to persistent and severe respiratory viral infection.
Transplant immunology
Gowdy KM,Martinu T,Nugent JL,Manzo ND,Zhang HL,Kelly FL,Holtzman MJ,Palmer SM
12-5971 was used in Flow cytometry/Cell sorting to study whether antiviral T cell immunity is impaired as a consequence of allogeneic bone marrow transplantation, and is responsible for increased susceptibility to respiratory viral infections.
Thu Jan 01 00:00:00 EST 2015
Enhanced Control of Bladder-Associated Tumors Using Shrimp Anti-Lipopolysaccharide Factor (SALF) Antimicrobial Peptide as a Cancer Vaccine Adjuvant in Mice.
Marine drugs
Huang HN,Rajanbabu V,Pan CY,Chan YL,Chen JY,Wu CJ
12-5971-82 was used in Immunohistochemistry (PFA fixed) to show that SALF added to cell culture media inhibits growth progression of MBT-2, and that SALF together with inactivated MBT-2 lysate elevates the level of inflammasome activity, and modulates the levels of IL-1β, MCP-1, IL-6, IL-12, and TNF-α in mouse macrophages.
Thu May 21 00:00:00 EDT 2015
Signaling pathways activated by a protease allergen in basophils.
Proceedings of the National Academy of Sciences of the United States of America
Rosenstein RK,Bezbradica JS,Yu S,Medzhitov R
12-5971 was used in Flow cytometry/Cell sorting to study signaling pathways activated by a protease allergen in basophils.
Tue Nov 18 00:00:00 EST 2014
T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes.
Mucosal immunology
Chu DK,Mohammed-Ali Z,Jiménez-Saiz R,Walker TD,Goncharova S,Llop-Guevara A,Kong J,Gordon ME,Barra NG,Gillgrass AE,Van Seggelen H,Khan WI,Ashkar AA,Bramson JL,Humbles AA,Kolbeck R,Waserman S,Jordana M
12-5971 was used in Flow cytometry/Cell sorting to reveal intestinal Th2 priming is initiated by an autocrine/paracrine acting CD4(+) Th cell-intrinsic IL-4 program that is controlled by DC OX40L.
Sat Nov 01 00:00:00 EDT 2014
Attenuating mutations in nsP1 reveal tissue-specific mechanisms for control of Ross River virus infection.
Journal of virology
Stoermer Burrack KA,Hawman DW,Jupille HJ,Oko L,Minor M,Shives KD,Gunn BM,Long KM,Morrison TE
12-5971 was used in an ELISA assay to demonstrate non-synonymous nucleotide alterations between the nsP1 and DC5692 genes determine virulence in a mouse model of Ross river virus.
Tue Apr 01 00:00:00 EDT 2014
Inhibition of eIF5A results in aberrant uterine natural killer cell function and embryo loss in mice.
American journal of reproductive immunology (New York, N.Y. : 1989)
Qin X,Liu X,Shan B,Shi L,Sharma S,Wu J,Lin Y
12-5971 was used in Flow cytometry/Cell sorting to investigate the effects of N1-guanyl-1,7-diaminoheptane, an inhibitor of eukaryotic initiation factor 5A, on natural killer cells in vitro.
Sat Mar 01 00:00:00 EST 2014
Interferon-mediated innate immune responses against malaria parasite liver stages.
Cell reports
Miller JL,Sack BK,Baldwin M,Vaughan AM,Kappe SHI
12-5971 was used in Flow cytometry/Cell sorting to demonstrate innate immune sensing of malaria parasite liver-stage infection and that the ensuing innate responses can eliminate the parasite.
Thu Apr 24 00:00:00 EDT 2014
Repeated exposure to Lutzomyia intermedia sand fly saliva induces local expression of interferon-inducible genes both at the site of injection in mice and in human blood.
PLoS neglected tropical diseases
Weinkopff T,de Oliveira CI,de Carvalho AM,Hauyon-La Torre Y,Muniz AC,Miranda JC,Barral A,Tacchini-Cottier F
12-5971 was used in Flow cytometry/Cell sorting to demonstrate that repeated exposure to Lu. intermedia SGS induces the expression of potentially host-protective IFN-inducible genes.
Mon Sep 08 00:00:00 EDT 2014
IL-2/anti-IL-2 complex attenuates renal ischemia-reperfusion injury through expansion of regulatory T cells.
Journal of the American Society of Nephrology : JASN
Kim MG,Koo TY,Yan JJ,Lee E,Han KH,Jeong JC,Ro H,Kim BS,Jo SK,Oh KH,Surh CD,Ahn C,Yang J
12-5971 was used in Flow cytometry/Cell sorting to evaluate IL-2C as a therapeutic strategy for the attenuation of acute kidney injury.
Tue Oct 01 00:00:00 EDT 2013
Concordant mast cell and basophil production by individual hematopoietic blast colony-forming cells.
Proceedings of the National Academy of Sciences of the United States of America
Metcalf D,Ng AP,Baldwin TM,Di Rago L,Mifsud S
12-5971 was used in Flow cytometry/Cell sorting to investigate the ability of murine bone marrow blast colony-forming cells to generate mast cells and basophils.
Tue May 28 00:00:00 EDT 2013
Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1.
PLoS pathogens
Caignard G,Leiva-Torres GA,Leney-Greene M,Charbonneau B,Dumaine A,Fodil-Cornu N,Pyzik M,Cingolani P,Schwartzentruber J,Dupaul-Chicoine J,Guo H,Saleh M,Veillette A,Lathrop M,Blanchette M,Majewski J,Pearson A,Vidal SM
12-5971 was used in Flow cytometry/Cell sorting to identify host factors involved in HSV-1 and herpes simplex encephalitis susceptibility in an in vivo HSV-1 infectious model.
Sun Sep 01 00:00:00 EDT 2013
Sequential engagement of FcεRI on Mast Cells and Basophil Histamine H(4) Receptor and FcεRI in Allergic Rhinitis.
Journal of immunology (Baltimore, Md. : 1950)
Shiraishi Y,Jia Y,Domenico J,Joetham A,Karasuyama H,Takeda K,Gelfand EW
12-5971 was used in Flow cytometry/Cell sorting to demonstrate how the development of allergic rhinitis has two distinct stages: histamine release from FcεRI-activated mast cells, followed by histamine-mediated recruitment of H(4)R-expressing basophils to the nasal cavity.
Tue Jan 15 00:00:00 EST 2013
Uterine natural killer cells severely decrease in number at gestation day 6 in mice.
Biology of reproduction
Takashima A,Ishikawa F,Kuwabara T,Tanaka Y,Kinoshita T,Ito M,Kakiuchi T
12-5971 was used in Flow cytometry/Cell sorting to study how uterine NK cells or their precursors migrate into the uterus, mature, and produce interferon-gamma to support pregnancy in mice.
Tue Oct 01 00:00:00 EDT 2013
Interferon gamma and T cells inhibit osteogenesis induced by allogeneic mesenchymal stromal cells.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Dighe AS,Yang S,Madhu V,Balian G,Cui Q
12-5971 was used in Flow cytometry/Cell sorting to investigate whether MSCs can be used for bone repair, showing that interferon gamma and T cells inhibit osteogenesis induced by allogeneic MSCs.
Fri Feb 01 00:00:00 EST 2013
Production of bioactive soluble interleukin-15 in complex with interleukin-15 receptor alpha from a conditionally-replicating oncolytic HSV-1.
PloS one
Gaston DC,Odom CI,Li L,Markert JM,Roth JC,Cassady KA,Whitley RJ,Parker JN
12-5971 was used in Flow cytometry/Cell sorting to engineer an oncolytic type-1 herpes simplex virus, producing bioactive IL-15.
Wed Dec 17 00:00:00 EST 2014
G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising CD8+ T cell immune responses.
Journal of hematology & oncology
Rubinstein MP,Salem ML,Doedens AL,Moore CJ,Chiuzan C,Rivell GL,Cole DJ,Goldrath AW
12-5971 was used in Flow cytometry/Cell sorting to evaluate whether the biological activity of G-CSF can be improved by pre-association with anti-G-CSF monoclonal antibodies prior to injection.
Tue Oct 01 00:00:00 EDT 2013
Mechanisms of NK cell-macrophage Bacillus anthracis crosstalk: a balance between stimulation by spores and differential disruption by toxins.
PLoS pathogens
Klezovich-Bénard M,Corre JP,Jusforgues-Saklani H,Fiole D,Burjek N,Tournier JN,Goossens PL
12-5971 was used in Flow cytometry/Cell sorting to investigate the mechanisms of cytokine and cellular signalling that underlies NK-cell activation by B. anthraci.
Sun Jan 01 00:00:00 EST 2012
Expression, regulation, and function of atypical chemerin receptor CCRL2 on endothelial cells.
Journal of immunology (Baltimore, Md. : 1950)
Monnier J,Lewén S,O'Hara E,Huang K,Tu H,Butcher EC,Zabel BA
12-5971 was used in Flow cytometry/Cell sorting to show that CCRL2 and VCAM-1 are upregulated on vascular endothelial cells by proinflammatory stimuli.
Sun Jul 15 00:00:00 EDT 2012
Lactobacillus gasseri suppresses Th17 pro-inflammatory response and attenuates allergen-induced airway inflammation in a mouse model of allergic asthma.
The British journal of nutrition
Jan RL,Yeh KC,Hsieh MH,Lin YL,Kao HF,Li PH,Chang YS,Wang JY
12-5971 was used in Flow cytometry/Cell sorting to show that oral administration of Lactobacillus gasseri can attenuate symptoms of allergen-induced airway inflammation in a mouse model of asthma.
Sat Jul 14 00:00:00 EDT 2012
Role of suppressor of cytokine signaling-1 in murine atherosclerosis.
PloS one
Grothusen C,Schuett H,Hillmer A,Lumpe S,Grote K,Ballmaier M,Bleich A,Glage S,Tietge UJ,Luchtefeld M,Schieffer B
12-5971 was used in Flow cytometry/Cell sorting to investigate the impact of systemic SOCS-1 deficiency on atherogenesis in the low-density lipoprotein receptor deficient murine model of atherosclerosis.
Wed Jul 17 00:00:00 EDT 2013
Endostatin gene therapy stimulates upregulation of ICAM-1 and VCAM-1 in a metastatic renal cell carcinoma model.
Cancer gene therapy
Chaves KC,Peron JP,Chammas R,Turaça LT,Pesquero JB,Braga MS,Foguer K,Schor N,Bellini MH
12-5971-82 was used in Flow cytometry/Cell sorting to demonstrate an antitumor inflammatory effect of Endostatin (ES) in an mRCC model, and this effect is mediated by an increase in ICAM-1 and VCAM-1 expression in tumor-associated endothelial cells.
Wed Aug 01 00:00:00 EDT 2012
Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independently of MHC.
Blood
Barao I,Alvarez M,Ames E,Orr MT,Stefanski HE,Blazar BR,Lanier LL,Anderson SK,Redelman D,Murphy WJ
12-5971 was used in Flow cytometry/Cell sorting to show that during reconstitution after HSCT and various activation stimuli, preferential expansion of the Ly49G2 receptor on NK cells occurs independently of MHC haplotype.
Thu Jun 30 00:00:00 EDT 2011
Distinct MHC class I-dependent NK cell-activating receptors control cytomegalovirus infection in different mouse strains.
The Journal of experimental medicine
Pyzik M,Charbonneau B,Gendron-Pontbriand EM,Babić M,Krmpotić A,Jonjić S,Vidal SM
12-5971 was used in Flow cytometry/Cell sorting to study how multiple activating Ly49 receptors may participate in H-2-dependent recognition of MCMV infection, providing a common mechanism of NK cell-mediated resistance against viral infection.
Mon May 09 00:00:00 EDT 2011
Activation of cytotoxic and regulatory functions of NK cells by Sindbis viral vectors.
PloS one
Granot T,Venticinque L,Tseng JC,Meruelo D
12-5971 was used in Flow cytometry/Cell sorting to study how Sindbis virus therapy affects NK cell function in SCID mice bearing human ovarian carcinoma tumors.
Fri Sep 30 00:00:00 EDT 2011
Neutrophil-derived CCL3 is essential for the rapid recruitment of dendritic cells to the site of Leishmania major inoculation in resistant mice.
PLoS pathogens
Charmoy M,Brunner-Agten S,Aebischer D,Auderset F,Launois P,Milon G,Proudfoot AE,Tacchini-Cottier F
12-5971 was used in Flow cytometry/Cell sorting to determine that the selective release of neutrophil-secreted chemokines may regulate the development of immune responses to pathogens.
Fri Feb 05 00:00:00 EST 2010
Ability of IDO to attenuate liver injury in alpha-galactosylceramide-induced hepatitis model.
Journal of immunology (Baltimore, Md. : 1950)
Ito H,Hoshi M,Ohtaki H,Taguchi A,Ando K,Ishikawa T,Osawa Y,Hara A,Moriwaki H,Saito K,Seishima M
12-5971 was used in Flow cytometry/Cell sorting to study the immunological effects of IDO in α-galactosylceramide (α-GalCer)-induced hepatitis.
Fri Oct 15 00:00:00 EDT 2010
Influenza infection leads to increased susceptibility to subsequent bacterial superinfection by impairing NK cell responses in the lung.
Journal of immunology (Baltimore, Md. : 1950)
Small CL,Shaler CR,McCormick S,Jeyanathan M,Damjanovic D,Brown EG,Arck P,Jordana M,Kaushic C,Ashkar AA,Xing Z
12-5971 was used in Flow cytometry/Cell sorting to identify weakened NK cell response in the lung to be a critical mechanism for flu-mediated susceptibility to bacterial superinfection.
Mon Feb 15 00:00:00 EST 2010
Intracellular staining for analysis of the expression and phosphorylation of signal transducers and activators of transcription (STATs) in NK cells.
Methods in molecular biology (Clifton, N.J.)
Miyagi T,Lee SH,Biron CA
12-5971 was used in Flow cytometry/Cell sorting to develop approaches to measure the levels of expression and activation of signalling molecules.
Fri Feb 26 00:00:00 EST 2010
Effect of polyI:C cotreatment on halothane-induced liver injury in mice.
Hepatology (Baltimore, Md.)
Cheng L,You Q,Yin H,Holt M,Franklin C,Ju C
12-5971 was used in Flow cytometry/Cell sorting to investigate the effect of viral infection on halothane-induced hepatotoxicity in mice using a viral RNA mimetic.
Thu Jan 01 00:00:00 EST 2009
Characterization of natural killer cells in nonobese diabetic/severely compromised immunodeficient mice during pregnancy.
Fertility and sterility
Lin Y,Zhong Y,Saito S,Chen Y,Shen W,Di J,Zeng S
12-5971 was used in Flow cytometry/Cell sorting to characterize uterine natural killer cells in non-obese diabetic/severely compromised immunodeficient mice and investigate their role in pregnancy tolerance.
Mon Jun 01 00:00:00 EDT 2009
Natural killer cells modulate overt autoimmunity to homeostasis in nonobese diabetic mice after anti-CD3 F(ab')2 antibody treatment through secreting transforming growth factor-beta.
The American journal of pathology
Chen G,Han G,Wang J,Wang R,Xu R,Shen B,Qian J,Li Y
12-5971 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the use of anti-CD3 for treatment of overt autoimmunity, showing that natural killer cells modulate autoimmunity through secreting TGF-beta.
Tue Sep 01 00:00:00 EDT 2009
In vivo expansion of activated naive CD8+ T cells and NK cells driven by complexes of IL-2 and anti-IL-2 monoclonal antibody as novel approach of cancer immunotherapy.
Journal of immunology (Baltimore, Md. : 1950)
Tomala J,Chmelova H,Mrkvan T,Rihova B,Kovar M
12-5971 was used in Flow cytometry/Cell sorting to investigate the potential for replacement of IL-2 by IL-2 immunocomplexes for cancer therapy.
Thu Oct 15 00:00:00 EDT 2009
Lymphocytes in the development of lung inflammation: a role for regulatory CD4+ T cells in indirect pulmonary lung injury.
Journal of immunology (Baltimore, Md. : 1950)
Venet F,Chung CS,Huang X,Lomas-Neira J,Chen Y,Ayala A
12-5971 was used in Flow cytometry/Cell sorting to demonstrate that CD4(+) regulatory T-cells are critical in control of neutrophil recruitment in indirect acute lung injury.
Tue Sep 01 00:00:00 EDT 2009
Deficient major histocompatibility complex-linked innate murine cytomegalovirus immunity in MA/My.L-H2b mice and viral downregulation of H-2k class I proteins.
Journal of virology
Xie X,Dighe A,Clark P,Sabastian P,Buss S,Brown MG
12-5971 was used in Flow cytometry/Cell sorting to show that replacement of MA/My H-2k with C57L H-2b susceptibility genes led to a remarkable loss of innate virus immunity.
Mon Jan 01 00:00:00 EST 2007
Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}.
Proceedings of the National Academy of Sciences of the United States of America
Rubinstein MP,Kovar M,Purton JF,Cho JH,Boyman O,Surh CD,Sprent J
12-5971 was used in Flow cytometry/Cell sorting to study how IL-2 function is markedly inhibited by binding to soluble IL-2Ralpha.
Tue Jun 13 00:00:00 EDT 2006
Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization.
The Journal of experimental medicine
Setoguchi R,Hori S,Takahashi T,Sakaguchi S
12-5971 was used in Flow cytometry/Cell sorting to evidence the homeostatic maintenance of Foxp3-expressing CD25+CD4+ regulatory T cells by interleukin (IL)-2, the neutralisation of which, produces a wide spectrum of T cell-mediated autoimmune diseases.
Mon Mar 07 00:00:00 EST 2005
Exogenous interleukin-12 protects against lethal infection with coxsackievirus B4.
Journal of virology
Potvin DM,Metzger DW,Lee WT,Collins DN,Ramsingh AI
12-5971 was used in Flow cytometry/Cell sorting to suggest that interleukin-12 treatment during coxsackievirus B4 infection is able to suppress the immunopathological mechanisms that lead to chronic disease.
Fri Aug 01 00:00:00 EDT 2003
