Product References
Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells.
Nature communications
Rožmanić C,Lisnić B,Pribanić Matešić M,Mihalić A,Hiršl L,Park E,Lesac Brizić A,Indenbirken D,Viduka I,Šantić M,Adler B,Yokoyama WM,Krmpotić A,Juranić Lisnić V,Jonjić S,Brizić I
Published figure using CD49b (Integrin alpha 2) monoclonal antibody (Product # 13-5971-82) in Flow Cytometry
Thu Oct 12 00:00:00 EDT 2023
Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells.
The Journal of experimental medicine
Hosokawa H,Koizumi M,Masuhara K,Romero-Wolf M,Tanaka T,Nakayama T,Rothenberg EV
Published figure using CD49b (Integrin alpha 2) monoclonal antibody (Product # 13-5971-82) in Flow Cytometry
Mon Aug 02 00:00:00 EDT 2021
Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells.
The Journal of experimental medicine
Hosokawa H,Koizumi M,Masuhara K,Romero-Wolf M,Tanaka T,Nakayama T,Rothenberg EV
Published figure using CD49b (Integrin alpha 2) monoclonal antibody (Product # 13-5971-82) in Flow Cytometry
Mon Aug 02 00:00:00 EDT 2021
Exosomes derived from retinoblastoma cells enhance tumour deterioration by infiltrating the microenvironment.
Oncology reports
Chen S,Chen X,Qiu J,Chen P,Han X,Wu Y,Zhuang J,Yang M,Wu C,Wu N,Yang Y,Ge J,Yu K,Zhuang J
Published figure using CD49b (Integrin alpha 2) monoclonal antibody (Product # 13-5971-82) in Immunohistochemistry
Fri Jan 01 00:00:00 EST 2021
Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy.
Immunity
Milner JJ,Toma C,He Z,Kurd NS,Nguyen QP,McDonald B,Quezada L,Widjaja CE,Witherden DA,Crowl JT,Shaw LA,Yeo GW,Chang JT,Omilusik KD,Goldrath AW
13-5971 was used in Flow cytometry/Cell sorting to identify discrete lineages of intestinal antigen-specific CD8+ T cells, including a Blimp1hiId3lo tissue-resident effector cell population most prominent in the early phase of acute viral and bacterial infections and a molecularly distinct Blimp1loId3hi tissue-resident memory population that subsequently accumulated at later infection time points.
Tue May 19 00:00:00 EDT 2020
Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease.
Cell reports
Nguyen HD,Ticer T,Bastian D,Kuril S,Li H,Du H,Yan C,Yu XZ
13-5971 was used in Flow cytometry/Cell sorting to reveal the role of LAL in T cell alloresponse and pathogenicity and validates LAL as a target for controlling GVHD and tumor relapse after allo-HCT.
Tue Oct 27 00:00:00 EDT 2020
Critical role of WNK1 in MYC-dependent early mouse thymocyte development.
eLife
Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL
13-5971 was used in Flow cytometry/Cell sorting to ind that WNK1 is required for the transition of double negative (DN) thymocytes through the β-selection checkpoint and subsequent proliferation and differentiation into double positive (DP) thymocytes.
Wed Oct 14 00:00:00 EDT 2020
IL-33-ST2 axis regulates myeloid cell differentiation and activation enabling effective club cell regeneration.
Nature communications
Dagher R,Copenhaver AM,Besnard V,Berlin A,Hamidi F,Maret M,Wang J,Qu X,Shrestha Y,Wu J,Gautier G,Raja R,Aubier M,Kolbeck R,Humbles AA,Pretolani M
13-5971-82 was used in Flow Cytometry to conclude that the IL-33-ST2 axis controls epithelial niche regeneration by activating a large multi-cellular circuit, including monocyte differentiation into competent repairing AAMs, as well as group-2 innate lymphoid cell (ILC2)-mediated AAM activation.
Tue Sep 22 00:00:00 EDT 2020
Interleukin-17-Producing γδ T Cells Originate from SOX13+ Progenitors that Are Independent of γδTCR Signaling.
Immunity
Spidale NA,Sylvia K,Narayan K,Miu B,Frascoli M,Melichar HJ,Zhihao W,Kisielow J,Palin A,Serwold T,Love P,Kobayashi M,Yoshimoto M,Jain N,Kang J
13-5971-82 was used in Flow Cytometry to generate reporter mice for the Tγδ17 lineage-defining transcription factor SOX13 and identify fetal-origin, intrathymic Sox13+ progenitors.
Tue Nov 20 00:00:00 EST 2018
Focal adhesion kinase (FAK) deficiency in mononuclear phagocytes alters murine breast tumor progression.
American journal of cancer research
Llewellyn RA,Gutknecht MF,Thomas KS,Conaway MR,Bouton AH
13-5971 was used in Flow cytometry/Cell sorting to determine that focal adhesion kinase expression in this cell population influences primary breast tumour initiation and growth.
Wed Sep 30 00:00:00 EDT 2020
A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.
eLife
Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY
13-5971 was used in Flow cytometry/Cell sorting to study the activation of Bcl11b, which controls T-cell fate commitment.
Tue Nov 20 00:00:00 EST 2018
The E-Id Protein Axis Specifies Adaptive Lymphoid Cell Identity and Suppresses Thymic Innate Lymphoid Cell Development.
Immunity
Miyazaki M,Miyazaki K,Chen K,Jin Y,Turner J,Moore AJ,Saito R,Yoshida K,Ogawa S,Rodewald HR,Lin YC,Kawamoto H,Murre C
13-5971 was used in Flow cytometry/Cell sorting to propose that the E-Id protein axis specifies innate and adaptive lymphoid cell fate.
Tue May 16 00:00:00 EDT 2017
Quality of TCR signaling determined by differential affinities of enhancers for the composite BATF-IRF4 transcription factor complex.
Nature immunology
Iwata A,Durai V,Tussiwand R,Briseño CG,Wu X,Grajales-Reyes GE,Egawa T,Murphy TL,Murphy KM
13-5971 was used in Flow cytometry/Cell sorting to study the mechanism by which the abundance of IRF4 induces distinct types of responses.
Mon May 01 00:00:00 EDT 2017
Acidic chitinase primes the protective immune response to gastrointestinal nematodes.
Nature immunology
Vannella KM,Ramalingam TR,Hart KM,de Queiroz Prado R,Sciurba J,Barron L,Borthwick LA,Smith AD,Mentink-Kane M,White S,Thompson RW,Cheever AW,Bock K,Moore I,Fitz LJ,Urban JF,Wynn TA
13-5971 was used in Flow cytometry/Cell sorting to use AMCase-deficient mice as a means to dissect the role of the enzyme in several models of helminth infection and type 2 cytokine-driven airway inflammation.
Sun May 01 00:00:00 EDT 2016
The breast tumor microenvironment alters the phenotype and function of natural killer cells.
Cellular & molecular immunology
Krneta T,Gillgrass A,Chew M,Ashkar AA
Published figure using CD49b (Integrin alpha 2) monoclonal antibody (Product # 13-5971-82) in Flow Cytometry
Thu Sep 01 00:00:00 EDT 2016
IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization.
The Journal of experimental medicine
Yoon J,Leyva-Castillo JM,Wang G,Galand C,Oyoshi MK,Kumar L,Hoff S,He R,Chervonsky A,Oppenheim JJ,Kuchroo VK,van den Brink MR,Malefyt Rde W,Tessier PA,Fuhlbrigge R,Rosenstiel P,Terhorst C,Murphy G,Geha RS
13-5971 was used in Flow cytometry/Cell sorting to elucidate the mechanisms behind DC-derived IL-23 in a model of skin inflammation.
Mon Sep 19 00:00:00 EDT 2016
Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.
eLife
Allison KA,Sajti E,Collier JG,Gosselin D,Troutman TD,Stone EL,Hedrick SM,Glass CK
13-5971 was used in Magnetic cell separation to investigate relationship between the strength of antigenic stimulation and the response of mouse CD4+ T cells.
Mon Jul 04 00:00:00 EDT 2016
A novel regulatory macrophage induced by a helminth molecule instructs IL-10 in CD4+ T cells and protects against mucosal inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Ziegler T,Rausch S,Steinfelder S,Klotz C,Hepworth MR,Kühl AA,Burda PC,Lucius R,Hartmann S
13-5971 was used in Magnetic cell separation to investigate the mechanism by which the helminth immunomodulator AvCystatin induces a novel regulatory macrophage able to protect against allergic mucosal inflammation in mice.
Sun Feb 15 00:00:00 EST 2015
DGCR14 induces Il17a gene expression through the RORγ/BAZ1B/RSKS2 complex.
Molecular and cellular biology
Takada I
13-5971 was used in Magnetic cell separation to show the roles of DGCR14, RSK2, and BAZ1B in the transcriptional regulation of Il17a mRNA during TH17 cell differentiation.
Thu Jan 01 00:00:00 EST 2015
Disease severity and mortality can be independently regulated in a mouse model of experimental graft versus host disease.
PloS one
Galvani RG,Lemos R,Areal RB,Salvador PA,Zamboni DS,Wanderley JL,Bonomo A
13-5971 was used in Magnetic cell separation to investigate the exact cause of death in graft versus host disease, showing that disease severity and mortality can be independently regulated.
Mon Oct 19 00:00:00 EDT 2015
Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2.
Cancer immunology research
Jiang H,Wang P,Li X,Wang Q,Deng ZB,Zhuang X,Mu J,Zhang L,Wang B,Yan J,Miller D,Zhang HG
13-5971 was used in Flow cytometry/Cell sorting to indicate that miR17/20a miRNAs function as tumor suppressors by reprogramming tumor cells for natural killer cell-mediated cytotoxicity.
Fri Aug 01 00:00:00 EDT 2014
Establishment of a murine graft-versus-myeloma model using allogeneic stem cell transplantation.
PloS one
Binsfeld M,Beguin Y,Belle L,Otjacques E,Hannon M,Briquet A,Heusschen R,Drion P,Zilberberg J,Bogen B,Baron F,Caers J
13-5971 was used in Flow cytometry/Cell sorting to investigate the anti-myeloma effects of allo-SCT from B10.D2 mice into MHC-matched myeloma-bearing Balb/cJ mice.
Tue Dec 15 00:00:00 EST 2015
Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.
The Journal of experimental medicine
Molofsky AB,Nussbaum JC,Liang HE,Van Dyken SJ,Cheng LE,Mohapatra A,Chawla A,Locksley RM
13-5971 was used in Flow cytometry/Cell sorting to study how ILC2s are resident in visceral adipose tissue and promote eosinophils and alternatively activated macrophages, implicated in metabolic homeostasis.
Mon Mar 11 00:00:00 EDT 2013
Evidence for a multipotent mammary progenitor with pregnancy-specific activity.
Breast cancer research : BCR
Kaanta AS,Virtanen C,Selfors LM,Brugge JS,Neel BG
13-5971 was used in Flow cytometry/Cell sorting to provide data to show the existence of multi-potent mammary progenitor cells that have pregnancy-specific function.
Mon Dec 08 00:00:00 EST 2014
Evidence for a multipotent mammary progenitor with pregnancy-specific activity.
Breast cancer research : BCR
Kaanta AS,Virtanen C,Selfors LM,Brugge JS,Neel BG
13-5971 was used in Flow cytometry/Cell sorting to provide data to show the existence of multi-potent mammary progenitor cells that have pregnancy-specific function.
Mon Dec 08 00:00:00 EST 2014
Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow niche.
Journal of immunology (Baltimore, Md. : 1950)
Zook EC,Zhang S,Gerstein RM,Witte PL,Le PT
13-5971 was used in Flow cytometry/Cell sorting to report that Foxn1 is expressed in wild-type BM and overexpressed in Foxn1Tg.
Sun Dec 01 00:00:00 EST 2013
Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade.
Nature communications
Leyva-Castillo JM,Hener P,Michea P,Karasuyama H,Chan S,Soumelis V,Li M
13-5971 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which thymic stromal lymphopoietin leads to Th2 initiation, showing that it occurs through an orchestrated immune cascade.
Tue Oct 07 00:00:00 EDT 2014
Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory.
The Journal of experimental medicine
Kaji T,Ishige A,Hikida M,Taka J,Hijikata A,Kubo M,Nagashima T,Takahashi Y,Kurosaki T,Okada M,Ohara O,Rajewsky K,Takemori T
13-5971 was used in Flow cytometry/Cell sorting to elucidate two differentiation pathways involved in the generation of B cell memory from germline-encoded and somatically mutated antibodies.
Mon Oct 22 00:00:00 EDT 2012
Transcription factor Smad-independent T helper 17 cell induction by transforming-growth factor-β is mediated by suppression of eomesodermin.
Immunity
Ichiyama K,Sekiya T,Inoue N,Tamiya T,Kashiwagi I,Kimura A,Morita R,Muto G,Shichita T,Takahashi R,Yoshimura A
13-5971 was used in Magnetic cell separation to investigate the molecular mechanisms by which TGF-beta allows Th17 cell differentiation via Smad-independent mechanisms, showing that Eomesodermin is suppressed by TGF-beta via the JNK pathway allowing differentiation.
Fri May 27 00:00:00 EDT 2011
Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and RORγt in mice.
Blood
Yu Y,Wang D,Liu C,Kaosaard K,Semple K,Anasetti C,Yu XZ
13-5971 was used in Functional assays to indicate that GVHD can be prevented by targeting Th1 and Th17 transcription factors without offsetting GVL activity.
Thu Nov 03 00:00:00 EDT 2011
Emergency granulopoiesis promotes neutrophil-dendritic cell encounters that prevent mouse lung allograft acceptance.
Blood
Kreisel D,Sugimoto S,Zhu J,Nava R,Li W,Okazaki M,Yamamoto S,Ibrahim M,Huang HJ,Toth KA,Ritter JH,Krupnick AS,Miller MJ,Gelman AE
13-5971 was used in Magnetic cell separation to identify granulopoiesis-mediated augmentation of alloimmunity as a novel link between innate and adaptive immune responses after organ transplantation.
Thu Dec 01 00:00:00 EST 2011
Vesicular stomatitis virus expressing tumor suppressor p53 is a highly attenuated, potent oncolytic agent.
Journal of virology
Heiber JF,Barber GN
Published figure using CD49b (Integrin alpha 2) monoclonal antibody (Product # 13-5971-82) in Western Blot
Sat Oct 01 00:00:00 EDT 2011
Online nanoflow multidimensional fractionation for high efficiency phosphopeptide analysis.
Molecular & cellular proteomics : MCP
Ficarro SB,Zhang Y,Carrasco-Alfonso MJ,Garg B,Adelmant G,Webber JT,Luckey CJ,Marto JA
13-5971 was used in Flow cytometry/Cell sorting to explore two novel multidimensional fractionation strategies for the gathering of phosphoproteomics data.
Tue Nov 01 00:00:00 EDT 2011
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells.
The Journal of experimental medicine
Edelson BT,KC W,Juang R,Kohyama M,Benoit LA,Klekotka PA,Moon C,Albring JC,Ise W,Michael DG,Bhattacharya D,Stappenbeck TS,Holtzman MJ,Sung SS,Murphy TL,Hildner K,Murphy KM
13-5971 was used in Flow cytometry/Cell sorting to study the relationship between nonlymphoid CD103-expressing dendritic cells (DCs) and other DC subsets.
Mon Apr 12 00:00:00 EDT 2010
Differential geminin requirement for proliferation of thymocytes and mature T cells.
Journal of immunology (Baltimore, Md. : 1950)
Karamitros D,Kotantaki P,Lygerou Z,Veiga-Fernandes H,Pachnis V,Kioussis D,Taraviras S
13-5971 was used in Magnetic cell separation to gain insight into the in vivo role of Geminin in progenitor cell division and differentiation.
Mon Mar 01 00:00:00 EST 2010
Intracellular staining for analysis of the expression and phosphorylation of signal transducers and activators of transcription (STATs) in NK cells.
Methods in molecular biology (Clifton, N.J.)
Miyagi T,Lee SH,Biron CA
13-5971 was used in Flow cytometry/Cell sorting to develop approaches to measure the levels of expression and activation of signalling molecules.
Fri Feb 26 00:00:00 EST 2010
Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection.
The Journal of experimental medicine
Lee HK,Zamora M,Linehan MM,Iijima N,Gonzalez D,Haberman A,Iwasaki A
13-5971 was used in Flow cytometry/Cell sorting to to study the differential roles of migratory and resident DC's in T cell priming after mucosal or skin HSV-1 infection.
Mon Feb 16 00:00:00 EST 2009
Unique receptor repertoire in mouse uterine NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Yadi H,Burke S,Madeja Z,Hemberger M,Moffett A,Colucci F
13-5971-82 was used in Flow Cytometry to define the receptor repertoire and phenotype of uterine NK cells at mid-gestation in mice.
Sat Nov 01 00:00:00 EDT 2008
Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice.
Blood
Nakae S,Suto H,Berry GJ,Galli SJ
13-5971 was used in Flow cytometry/Cell sorting to show that through FcRgamma-independent mechanisms, mast cells (and derived TNF) can enhance an Ag- and Th17 cell-dependent inflammatory response.
Tue May 01 00:00:00 EDT 2007
Loss of T cell receptor-induced Bmi-1 in the KLRG1(+) senescent CD8(+) T lymphocyte.
Proceedings of the National Academy of Sciences of the United States of America
Heffner M,Fearon DT
13-5971 was used in Immunopurification to indicate that Bmi-1 is required for CD8(+) T cell clonal expansion and is positively regulated by receptors that mediate this response.
Tue Aug 14 00:00:00 EDT 2007
