Invitrogen

CD4 Monoclonal Antibody (GK1.5), Biotin, eBioscience™

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

96 Published Figures

214 References

View all (605) CD4 antibodies

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CD4 Antibody (13-0041-82) in Flow

Staining of C57BL/6 splenocytes with 0.125 µg of Rat IgG2b kappa Isotype Control Biotin (Product # 13-4031-82) (open histogram) or 0.125 µg of Anti-Mouse CD4 Biotin (filled histogram) followed by Streptavidin PE (Product # 12-4317-87). Total viable cells were used for analysis.

CD4 Antibody in Immunocytochemistry (ICC/IF)

CD4 Antibody in Immunocytochemistry, Flow Cytometry (ICC/IF, Flow)

CD4 Antibody in Immunohistochemistry (Frozen) (IHC (F))

CD4 Antibody in Immunohistochemistry (IHC)

CD4 Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)

Product Image Gallery

CD4 Antibody — Staining of mouse splenocytes. As expected based on known relative expression patterns, CD4 clone GK1.5 stains about 25% of total lymphocytes and does not stain CD45R (B220)+ B cells. Details: Balb/c splenocytes were surface stained with CD45R (B220, clone RA3-6B2) and Rat IgG2b Isotype Control or CD4 (clone GK1.5). Cells in the lymphocyte gate were used for analysis. {RE}

Product Details

13-0041-82

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 20 publications 20 publications

Immunohistochemistry (Frozen) (IHC (F))

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Flow Cytometry (Flow)

0.25 µg/test

View 180 publications 180 publications

Functional Assay (Functional)

View 3 publications 3 publications

Miscellaneous PubMed (Misc)

View 5 publications 5 publications

Product Specifications

Species Reactivity

Mouse

Published species

Fish, Human, Mouse

Host/Isotype

Rat / IgG2b, kappa

Recommended Isotype Control

Rat IgG2b kappa Isotype Control (eB149/10H5), Biotin, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

GK1.5

Conjugate

Biotin Biotin Biotin

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_466325

Product Specific Information

Description: The GK1.5 monoclonal antibody reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor expressed by a majority of thymocytes, subpopulation of mature T cells and dendritic cells. CD4 binds to MHC class II on the surface of antigen presenting cells and plays an important role both in T cell development and in optimal functioning of mature T cells. In T cells, CD4 associates with protein tyrosine kinase p56lck through its cytoplasmic tail. Binding of GK1.5 is blocked by RM4-5.

Applications Reported: The GK1.5 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The GK1.5 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge.

Biomaterials

Sun S,Li E,Zhao G,Tang J,Zuo Q,Cai L,Xu C,Sui C,Ou Y,Liu C,Li H,Ding Y,Li C,Lu D,Zhang W,Luo P,Cheng P,Gao Y,Tu C,Pitard B,Rosenecker J,Wang B,Liu Y,Zou Q,Guan S

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2023

HSF1 promotes CD69⁺ Treg differentiation to inhibit colitis progression.

Theranostics

Yu L,Zhou B,Zhu Y,Li L,Zhong Y,Zhu L,Wang H,Chen H,Xu J,Guo T,Feng L,Wang X,Cai Z,Wang J,Jin H

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Apr 18 00:00:00 EDT 2023

Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-like Autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Hodgson R,Crockford TL,Bhandari A,Kepple JD,Back J,Cawthorne E,Abeler-Dörner L,Laing AG,Clare S,Speak A,Adams DJ,Dougan G,Hayday AC,Deobagkar-Lele M,Cornall RJ,Bull KR

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting.

Frontiers in immunology

Clubb JHA,Kudling TV,Girych M,Haybout L,Pakola S,Hamdan F,Cervera-Carrascon V,Hemmes A,Grönberg-Vähä-Koskela S,Santos JM,Quixabeira DCA,Basnet S,Heiniö C,Arias V,Jirovec E,Kaptan S,Havunen R,Sorsa S,Erikat A,Schwartz J,Anttila M,Aro K,Viitala T,Vattulainen I,Cerullo V,Kanerva A,Hemminki A

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Feb 27 00:00:00 EST 2023

GH18 family glycoside hydrolase Chitinase A of Salmonella enhances virulence by facilitating invasion and modulating host immune responses.

PLoS pathogens

Chandra K,Roy Chowdhury A,Chatterjee R,Chakravortty D

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Apr 01 00:00:00 EDT 2022

Rotenone aggravates PD-like pathology in A53T mutant human α-synuclein transgenic mice in an age-dependent manner.

Frontiers in aging neuroscience

Chen AD,Cao JX,Chen HC,Du HL,Xi XX,Sun J,Yin J,Jing YH,Gao LP

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Aug 26 00:00:00 EDT 2022

IL-33 Deficiency Attenuates Lung Inflammation by Inducing Th17 Response and Impacting the Th17/Treg Balance in LPS-Induced ARDS Mice via Dendritic Cells.

Journal of immunology research

Cheng L,Jiao Y,Jiang W,Zhang X,Zhang L,Jia G

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Dec 27 00:00:00 EST 2022

Interferon-γ Stimulates Interleukin-27 Derived from Dendritic Cells to Regulate Th9 Differentiation through STAT1/3 Pathway.

Disease markers

Xiong P,Liu T,Chen Y,Xu Q,Hu X,Han F,Shi L

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Oct 31 00:00:00 EDT 2022

CD4⁺ CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.

Aging and disease

Shen S,Li Y,Jin M,Fan D,Pan R,Lin A,Chen Y,Xiang L,Zhao RC,Shao J

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2022

Free Fatty Acid Receptor 4 (FFA4) Activation Ameliorates Imiquimod-Induced Psoriasis in Mice.

International journal of molecular sciences

Son SE,Koh JM,Im DS

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Apr 19 00:00:00 EDT 2022

Btla signaling in conventional and regulatory lymphocytes coordinately tempers humoral immunity in the intestinal mucosa.

Cell reports

Stienne C,Virgen-Slane R,Elmén L,Veny M,Huang S,Nguyen J,Chappell E,Balmert MO,Shui JW,Hurchla MA,Kronenberg M,Peterson SN,Murphy KM,Ware CF,Šedý JR

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunohistochemistry

Tue Mar 22 00:00:00 EDT 2022

Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage.

Cell death & disease

Del Rio Oliva M,Basler M

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2022

Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.

Immunity

Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury in a non-human primate model of COVID-19.

Nature nanotechnology

Li Z,Wang Z,Dinh PC,Zhu D,Popowski KD,Lutz H,Hu S,Lewis MG,Cook A,Andersen H,Greenhouse J,Pessaint L,Lobo LJ,Cheng K

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunocytochemistry

Sun Aug 01 00:00:00 EDT 2021

NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.

Nature immunology

Gu M,Zhou X,Sohn JH,Zhu L,Jie Z,Yang JY,Zheng X,Xie X,Yang J,Shi Y,Brightbill HD,Kim JB,Wang J,Cheng X,Sun SC

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase.

International journal of oral science

Zhao X,Liu J,Zhang C,Yu N,Lu Z,Zhang S,Li Y,Li Q,Liu J,Liu D,Pan Y

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss.

The Journal of clinical investigation

Yu W,Zhong L,Yao L,Wei Y,Gui T,Li Z,Kim H,Holdreith N,Jiang X,Tong W,Dyment N,Liu XS,Yang S,Choi Y,Ahn J,Qin L

13-0041 was used in Flow cytometry/Cell sorting to identify MALPs as a critical player in controlling bone remodeling during normal bone metabolism and pathological bone loss in a RANKL-dependent fashion.

Tue Jan 19 00:00:00 EST 2021

Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.

The Journal of experimental medicine

Sasai M,Ma JS,Okamoto M,Nishino K,Nagaoka H,Takashima E,Pradipta A,Lee Y,Kosako H,Suh PG,Yamamoto M

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Jul 05 00:00:00 EDT 2021

High Ambient Temperature Aggravates Experimental Autoimmune Uveitis Symptoms.

Frontiers in cell and developmental biology

Pan S,Tan H,Chang R,Wang Q,Zhu Y,Chen L,Li H,Su G,Zhou C,Cao Q,Kijlstra A,Yang P

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Apr 13 00:00:00 EDT 2021

Dynamic changes in the systemic immune responses of spinal cord injury model mice.

Neural regeneration research

Gao TY,Huang FF,Xie YY,Wang WQ,Wang LD,Mu D,Cui Y,Wang B

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Generation of a Novel Oncolytic Vaccinia Virus Using the IHD-W Strain.

Human gene therapy

Shin J,Hong SO,Kim M,Lee H,Choi H,Kim J,Hong J,Kang H,Lee E,Lee S,Kong B,Kim M,Choi H,Kim S

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

CXCR3 alleviates renal ischemia‑reperfusion injury via increase of Tregs.

Molecular medicine reports

Xian W,Wu J,Li Q,Du X,Wang N,Chen D,Gao W,Cao J

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Jul 01 00:00:00 EDT 2021

Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.

Oncology letters

Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Preliminary analysis of immunoregulatory mechanism of hyperhomocysteinemia-induced brain injury in Wistar-Kyoto rats.

Experimental and therapeutic medicine

Zhang Y,Wang L,Li X,Geng J

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Estrogen receptor beta signaling in CD8⁺ T cells boosts T cell receptor activation and antitumor immunity through a phosphotyrosine switch.

Journal for immunotherapy of cancer

Yuan B,Clark CA,Wu B,Yang J,Drerup JM,Li T,Jin VX,Hu Y,Curiel TJ,Li R

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2021

TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells.

JCI insight

de Mattos Barbosa MG,Lefferts AR,Huynh D,Liu H,Zhang Y,Fu B,Barnes J,Samaniego M,Bram RJ,Geha RS,Shikanov A,Prak ETL,Farkash EA,Platt JL,Cascalho M

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunohistochemistry

Wed Sep 08 00:00:00 EDT 2021

Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy.

Frontiers in immunology

Agalave NM,Mody PH,Szabo-Pardi TA,Jeong HS,Burton MD

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Sep 20 00:00:00 EDT 2021

Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model.

Vaccines

Trofimova O,Korotkaja K,Skrastina D,Jansons J,Spunde K,Isaguliants M,Zajakina A

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Oct 27 00:00:00 EDT 2021

A lymph node-targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2.

Science advances

Steinbuck MP,Seenappa LM,Jakubowski A,McNeil LK,Haqq CM,DeMuth PC

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.

International journal of molecular sciences

Sato S,Shimizu E,He J,Ogawa M,Asai K,Yazu H,Rusch R,Yamane M,Yang F,Fukuda S,Kawakami Y,Tsubota K,Ogawa Y

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunohistochemistry

Sat Apr 03 00:00:00 EDT 2021

Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.

International journal of molecular sciences

Sato S,Shimizu E,He J,Ogawa M,Asai K,Yazu H,Rusch R,Yamane M,Yang F,Fukuda S,Kawakami Y,Tsubota K,Ogawa Y

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunohistochemistry

Sat Apr 03 00:00:00 EDT 2021

Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression.

Clinical and translational medicine

Cheng CS,Tan HY,Wang N,Chen L,Meng Z,Chen Z,Feng Y

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunohistochemistry

Tue Jun 01 00:00:00 EDT 2021

IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation.

Frontiers in immunology

Amobi-McCloud A,Muthuswamy R,Battaglia S,Yu H,Liu T,Wang J,Putluri V,Singh PK,Qian F,Huang RY,Putluri N,Tsuji T,Lugade AA,Liu S,Odunsi K

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Oct 29 00:00:00 EDT 2021

Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells.

Stem cell research & therapy

Liu W,Zhou N,Liu Y,Zhang W,Li X,Wang Y,Zheng R,Zhang Y

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Feb 26 00:00:00 EST 2021

G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence.

Cell death & disease

Sun SN,Ni SH,Li Y,Liu X,Deng JP,Chen ZX,Li H,Feng WJ,Huang YS,Li DN,Xian SX,Yang ZQ,Wang LJ,Lu L

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Jun 08 00:00:00 EDT 2021

Butyrate Improves Skin/Lung Fibrosis and Intestinal Dysbiosis in Bleomycin-Induced Mouse Models.

International journal of molecular sciences

Park HJ,Jeong OY,Chun SH,Cheon YH,Kim M,Kim S,Lee SI

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Mar 09 00:00:00 EST 2021

Mapping Rora expression in resting and activated CD4+ T cells.

PloS one

Haim-Vilmovsky L,Henriksson J,Walker JA,Miao Z,Natan E,Kar G,Clare S,Barlow JL,Charidemou E,Mamanova L,Chen X,Proserpio V,Pramanik J,Woodhouse S,Protasio AV,Efremova M,Griffin JL,Berriman M,Dougan G,Fisher J,Marioni JC,McKenzie ANJ,Teichmann SA

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Nov 12 00:00:00 EST 2021

Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid.

The Journal of biological chemistry

Zhao Y,Cheng R,Zhao Y,Ge W,Yang Y,Ding Z,Xu X,Wang Z,Wu Z,Zhang J

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Oct 01 00:00:00 EDT 2021

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.

Cancers

Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Oct 07 00:00:00 EDT 2021

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.

Cancers

Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Oct 07 00:00:00 EDT 2021

A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.

Nature communications

Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Sang W,Xie L,Wang G,Li J,Zhang Z,Li B,Guo S,Deng CX,Dai Y

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Systemic Delivery of Oncolytic Adenovirus to Tumors Using Tumor-Infiltrating Lymphocytes as Carriers.

Cells

Santos J,Heiniö C,Quixabeira D,Zafar S,Clubb J,Pakola S,Cervera-Carrascon V,Havunen R,Kanerva A,Hemminki A

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Apr 22 00:00:00 EDT 2021

Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response.

Cell reports

Vaena S,Chakraborty P,Lee HG,Janneh AH,Kassir MF,Beeson G,Hedley Z,Yalcinkaya A,Sofi MH,Li H,Husby ML,Stahelin RV,Yu XZ,Mehrotra S,Ogretmen B

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunocytochemistry

Tue May 04 00:00:00 EDT 2021

Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.

Theranostics

Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Jan 28 00:00:00 EST 2022

Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair.

Frontiers in immunology

Ramavath NN,Gadipudi LL,Provera A,Gigliotti LC,Boggio E,Bozzola C,Albano E,Dianzani U,Sutti S

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Feb 14 00:00:00 EST 2022

Remote Limb Ischemic Postconditioning Protects Against Ischemic Stroke by Promoting Regulatory T Cells Thriving.

Journal of the American Heart Association

Yu HH,Ma XT,Ma X,Chen M,Chu YH,Wu LJ,Wang W,Qin C,Tian DS

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Nov 16 00:00:00 EST 2021

TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling.

Cell reports

Agarwal P,Li H,Choi K,Hueneman K,He J,Welner RS,Starczynowski DT,Bhatia R

13-0041-82 was used in Flow Cytometry to find that TNF-α-mediated alterations in CML BM stromal niches enhance support of LSC maintenance and growth via CXCL1-CXCR2 signaling and that CXCR2 inhibition effectively depletes CML LSCs.

Tue Jul 13 00:00:00 EDT 2021

Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.

Frontiers in immunology

Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Jul 05 00:00:00 EDT 2021

Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.

Immunity

Bonavita E,Bromley CP,Jonsson G,Pelly VS,Sahoo S,Walwyn-Brown K,Mensurado S,Moeini A,Flanagan E,Bell CR,Chiang SC,Chikkanna-Gowda CP,Rogers N,Silva-Santos B,Jaillon S,Mantovani A,Reis e Sousa C,Guerra N,Davis DM,Zelenay S

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Dec 15 00:00:00 EST 2020

Splenic Capture and In Vivo Intracellular Biodegradation of Biological-Grade Graphene Oxide Sheets.

ACS nano

Newman L,Jasim DA,Prestat E,Lozano N,de Lazaro I,Nam Y,Assas BM,Pennock J,Haigh SJ,Bussy C,Kostarelos K

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Aug 25 00:00:00 EDT 2020

Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.

The Journal of experimental medicine

Kang YA,Pietras EM,Passegué E

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Mar 02 00:00:00 EST 2020

Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.

The Journal of experimental medicine

Kang YA,Pietras EM,Passegué E

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Mar 02 00:00:00 EST 2020

Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells.

PLoS pathogens

Akhtar MN,Mishra M,Yadav V,Yadav M,Gujar R,Lal S,Kumar R,Khatri N,Sen P

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Th2 cells promote eosinophil-independent pathology in a murine model of allergic bronchopulmonary aspergillosis.

European journal of immunology

Dietschmann A,Schruefer S,Krappmann S,Voehringer D

13-0041-82 was used in Flow Cytometry to use a mouse model of ABPA to investigate the role of eosinophils and T cell-derived IL-4/IL-13 for induction of allergic lung inflammation.

Wed Jul 01 00:00:00 EDT 2020

DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma.

Journal of cellular and molecular medicine

Song Y,Wang Z,Jiang J,Piao Y,Li L,Xu C,Piao H,Li L,Yan G

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.

Journal of cellular and molecular medicine

Wu R,Liu C,Deng X,Chen L,Hao S,Ma L

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.

Journal of Cancer

Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Effects of combined treatment with PD‑L1 Ig and CD40L mAb on immune tolerance in the CBA/J x DBA/2 mouse model.

Molecular medicine reports

Li G,Yang L,Li D,Zhang J,Du L,Xia L,Liu Y,Hu W

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

FUT1 deficiency elicits immune dysregulation and corneal opacity in steady state and under stress.

Cell death & disease

Kim KW,Ryu JS,Ko JH,Kim JY,Kim HJ,Lee HJ,Oh JH,Chung JH,Oh JY

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Apr 24 00:00:00 EDT 2020

Elevated granulocytic myeloid-derived suppressor cells are closely related with elevation of Th17 cells in mice with experimental asthma.

International journal of biological sciences

Xue F,Yu M,Li L,Zhang W,Ma Y,Dong L,Shan W,Zheng Y,Wang T,Feng D,Lv J,Wang X

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Nov 12 00:00:00 EST 2021

Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.

International journal of molecular sciences

Yoon CH,Ryu JS,Hwang HS,Kim MK

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Jun 11 00:00:00 EDT 2020

Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma.

Cells

Martinikova AS,Burocziova M,Stoyanov M,Macurek L

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Sep 10 00:00:00 EDT 2020

Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.

JCI insight

Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Aug 20 00:00:00 EDT 2020

Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.

Communications biology

Waaler J,Mygland L,Tveita A,Strand MF,Solberg NT,Olsen PA,Aizenshtadt A,Fauskanger M,Lund K,Brinch SA,Lycke M,Dybing E,Nygaard V,Bøe SL,Heintz KM,Hovig E,Hammarström C,Corthay A,Krauss S

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Apr 24 00:00:00 EDT 2020

The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function.

International journal of molecular sciences

Subbannayya Y,Haug M,Pinto SM,Mohanty V,Meås HZ,Flo TH,Prasad TSK,Kandasamy RK

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Dec 29 00:00:00 EST 2020

Methylation of a CGATA element inhibits binding and regulation by GATA-1.

Nature communications

Yang L,Chen Z,Stout ES,Delerue F,Ittner LM,Wilkins MR,Quinlan KGR,Crossley M

13-0041 was used in Flow cytometry/Cell sorting to show that the erythroid transcription factor GATA-1 - that typically binds T/AGATA sites - can also recognise CGATA elements, but only if the CpG dinucleotide is unmethylated.

Fri May 22 00:00:00 EDT 2020

ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.

PloS one

Hanson A,Elpek K,Duong E,Shallberg L,Fan M,Johnson C,Wallace M,Mabry GR,Sazinsky S,Pepper L,Shu CJ,Sathyanarayanan S,Zuerndorfer S,Simpson T,Gostissa M,Briskin M,Law D,Michaelson J,Harvey CJ

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Nov 16 00:00:00 EST 2020

Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment.

eLife

Zhong L,Yao L,Tower RJ,Wei Y,Miao Z,Park J,Shrestha R,Wang L,Yu W,Holdreith N,Huang X,Zhang Y,Tong W,Gong Y,Ahn J,Susztak K,Dyment N,Li M,Long F,Chen C,Seale P,Qin L

13-0041 was used in Flow cytometry/Cell sorting to computationally define mesenchymal progenitors at different stages and delineate their bi-lineage differentiation paths in young, adult and aging mice.

Tue Apr 14 00:00:00 EDT 2020

Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.

Scientific reports

Kedzierska AE,Lorek D,Slawek A,Chelmonska-Soyta A

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Jun 29 00:00:00 EDT 2020

Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.

Frontiers in immunology

Yu Y,Wu DM,Li J,Deng SH,Liu T,Zhang T,He M,Zhao YY,Xu Y

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Jun 21 00:00:00 EDT 2021

CD71⁺ Erythroid Cells in Human Neonates Exhibit Immunosuppressive Properties and Compromise Immune Response Against Systemic Infection in Neonatal Mice.

Frontiers in immunology

Elahi S,Vega-López MA,Herman-Miguel V,Ramírez-Estudillo C,Mancilla-Ramírez J,Motyka B,West L,Oyegbami O

13-0041-82 was used in Flow Cytometry to study the frequency and functionality of CD71+ erythroid cells in the peripheral blood of human newborns/children from 1-day to 5-year and compared them with their counterparts in the neonatal mice.

Mon Dec 28 00:00:00 EST 2020

Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.

Nature

Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S

13-0041 was used in Flow cytometry/Cell sorting to identify polyvinyl alcohol as a functionally superior replacement for serum albumin that is compatible with good manufacturing practice.

Mon Jul 01 00:00:00 EDT 2019

Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.

Nature

Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S

13-0041 was used in Flow cytometry/Cell sorting to identify polyvinyl alcohol as a functionally superior replacement for serum albumin that is compatible with good manufacturing practice.

Mon Jul 01 00:00:00 EDT 2019

Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.

Cell host & microbe

Gogokhia L,Buhrke K,Bell R,Hoffman B,Brown DG,Hanke-Gogokhia C,Ajami NJ,Wong MC,Ghazaryan A,Valentine JF,Porter N,Martens E,O'Connell R,Jacob V,Scherl E,Crawford C,Stephens WZ,Casjens SR,Longman RS,Round JL

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Feb 13 00:00:00 EST 2019

Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells.

Cell stem cell

Agarwal P,Isringhausen S,Li H,Paterson AJ,He J,Gomariz Á,Nagasawa T,Nombela-Arrieta C,Bhatia R

13-0041-82 was used in Flow Cytometry to highlight a critical role of niche-specific effects of Cxcl12 expression in maintaining quiescence of TKI-resistant LSC populations.

Thu May 02 00:00:00 EDT 2019

SIRT1 regulates metabolism and leukemogenic potential in CML stem cells.

The Journal of clinical investigation

Abraham A,Qiu S,Chacko BK,Li H,Paterson A,He J,Agarwal P,Shah M,Welner R,Darley-Usmar VM,Bhatia R

13-0041 was used in Flow cytometry/Cell sorting to demonstrate an important role for SIRT1 in leukemia development.

Mon Jun 10 00:00:00 EDT 2019

Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.

Laboratory investigation; a journal of technical methods and pathology

Hensel JA,Khattar V,Ashton R,Ponnazhagan S

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2019

Bryostatin-1 ameliorated experimental colitis in Il-10^-/- Mice by protecting the intestinal barrier and limiting immune dysfunction.

Journal of cellular and molecular medicine

Zuo L,Li J,Ge S,Ge Y,Shen M,Wang Y,Zhou C,Wu R,Hu J

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Aug 01 00:00:00 EDT 2019

Lactobacillus rhamnosus GG attenuates tenofovir disoproxil fumarate-induced bone loss in male mice via gut-microbiota-dependent anti-inflammation.

Therapeutic advances in chronic disease

Liu H,Gu R,Li W,Zhou W,Cong Z,Xue J,Liu Y,Wei Q,Zhou Y

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Sat Apr 09 00:00:00 EDT 2022

Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway.

Mediators of inflammation

Xu Y,Tang X,Yang M,Zhang S,Li S,Chen Y,Liu M,Guo Y,Lu M

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Jun 11 00:00:00 EDT 2019

IL-31 plays dual roles in lung inflammation in an OVA-induced murine asthma model.

Biology open

Huang J,Yue H,Jiang T,Gao J,Shi Y,Shi B,Wu X,Gou X

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Jan 15 00:00:00 EST 2019

Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.

Anti-cancer drugs

Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Epithelial EP4 plays an essential role in maintaining homeostasis in colon.

Scientific reports

Matsumoto Y,Nakanishi Y,Yoshioka T,Yamaga Y,Masuda T,Fukunaga Y,Sono M,Yoshikawa T,Nagao M,Araki O,Ogawa S,Goto N,Hiramatsu Y,Breyer RM,Fukuda A,Seno H

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunohistochemistry

Wed Oct 23 00:00:00 EDT 2019

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses.

NPJ vaccines

Li G,Adam A,Luo H,Shan C,Cao Z,Fontes-Garfias CR,Sarathy VV,Teleki C,Winkelmann ER,Liang Y,Sun J,Bourne N,Barrett ADT,Shi PY,Wang T

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Next Generation Sequencing for Long Non-coding RNAs Profile for CD4⁺ T Cells in the Mouse Model of Acute Asthma.

Frontiers in genetics

Wang Z,Ji N,Chen Z,Wu C,Sun Z,Yu W,Hu F,Huang M,Zhang M

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Apr 08 00:00:00 EDT 2022

Sex Differences in Mouse Popliteal Lymph Nodes.

Scientific reports

Dill-Garlow R,Chen KE,Walker AM

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Jan 30 00:00:00 EST 2019

TLR1/2 Specific Small-Molecule Agonist Suppresses Leukemia Cancer Cell Growth by Stimulating Cytotoxic T Lymphocytes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cen X,Zhu G,Yang J,Yang J,Guo J,Jin J,Nandakumar KS,Yang W,Yin H,Liu S,Cheng K

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri May 17 00:00:00 EDT 2019

Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles.

Cell reports

Cianciaruso C,Beltraminelli T,Duval F,Nassiri S,Hamelin R,Mozes A,Gallart-Ayala H,Ceada Torres G,Torchia B,Ries CH,Ivanisevic J,De Palma M

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Jun 04 00:00:00 EDT 2019

Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia.

Nature medicine

Zhang B,Nguyen LXT,Li L,Zhao D,Kumar B,Wu H,Lin A,Pellicano F,Hopcroft L,Su YL,Copland M,Holyoake TL,Kuo CJ,Bhatia R,Snyder DS,Ali H,Stein AS,Brewer C,Wang H,McDonald T,Swiderski P,Troadec E,Chen CC,Dorrance A,Pullarkat V,Yuan YC,Perrotti D,Carlesso N,Forman SJ,Kortylewski M,Kuo YH,Marcucci G

13-0041 was used in Flow cytometry/Cell sorting to demonstrate how bone marrow endothelial cells supply miR-126 to leukemia stem cells in chronic myelogenous leukemia which modulates their quiescence and self-renewal.

Tue May 01 00:00:00 EDT 2018

Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells.

Immunity

Halim TYF,Rana BMJ,Walker JA,Kerscher B,Knolle MD,Jolin HE,Serrao EM,Haim-Vilmovsky L,Teichmann SA,Rodewald HR,Botto M,Vyse TJ,Fallon PG,Li Z,Withers DR,McKenzie ANJ

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Jun 19 00:00:00 EDT 2018

Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.

Cell stem cell

Yamamoto R,Wilkinson AC,Ooehara J,Lan X,Lai CY,Nakauchi Y,Pritchard JK,Nakauchi H

13-0041 was used in Flow cytometry/Cell sorting to determine the age-related functional changes to the haematopoietic stem cell compartment.

Thu Apr 05 00:00:00 EDT 2018

Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling.

The Journal of clinical investigation

Emmerson A,Trevelin SC,Mongue-Din H,Becker PD,Ortiz C,Smyth LA,Peng Q,Elgueta R,Sawyer G,Ivetic A,Lechler RI,Lombardi G,Shah AM

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Jul 02 00:00:00 EDT 2018

IL1RAP potentiates multiple oncogenic signaling pathways in AML.

The Journal of experimental medicine

Mitchell K,Barreyro L,Todorova TI,Taylor SJ,Antony-Debré I,Narayanagari SR,Carvajal LA,Leite J,Piperdi Z,Pendurti G,Mantzaris I,Paietta E,Verma A,Gritsman K,Steidl U

13-0041 was used in Flow cytometry/Cell sorting to show that targeting of interleukin-1 receptor accessory protein via RNA interference, genetic deletion, or antibodies inhibits acute myeloid leukaemia pathogenesis in vitro and in vivo.

Mon Jun 04 00:00:00 EDT 2018

Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.

Molecular therapy : the journal of the American Society of Gene Therapy

Ricca JM,Oseledchyk A,Walther T,Liu C,Mangarin L,Merghoub T,Wolchok JD,Zamarin D

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Apr 04 00:00:00 EDT 2018

MicroRNA-126 deficiency enhanced the activation and function of CD4⁺ T cells by elevating IRS-1 pathway.

Clinical and experimental immunology

Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells.

World journal of gastroenterology

Müller-Graff FT,Fitzner B,Jaster R,Vollmar B,Zechner D

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Sat Jul 28 00:00:00 EDT 2018

Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.

Evidence-based complementary and alternative medicine : eCAM

Pang P,Zheng K,Wu S,Xu H,Deng L,Shi Y,Chen X

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.

Nature communications

Xu Y,Ikeda S,Sumida K,Yamamoto R,Tanaka H,Minato N

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Mar 02 00:00:00 EST 2018

Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.

JCI insight

McCall CE,Zabalawi M,Liu T,Martin A,Long DL,Buechler NL,Arts RJW,Netea M,Yoza BK,Stacpoole PW,Vachharajani V

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Aug 09 00:00:00 EDT 2018

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.

eLife

Lian G,Gnanaprakasam JR,Wang T,Wu R,Chen X,Liu L,Shen Y,Yang M,Yang J,Chen Y,Vasiliou V,Cassel TA,Green DR,Liu Y,Fan TW,Wang R

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Sep 10 00:00:00 EDT 2018

A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.

Nature communications

Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Apr 18 00:00:00 EDT 2018

Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Peng J,Xiao Y,Li W,Yang Q,Tan L,Jia Y,Qu Y,Qian Z

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue May 01 00:00:00 EDT 2018

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.

eLife

Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Nov 20 00:00:00 EST 2018

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.

Journal of neuroinflammation

Unger MS,Schernthaner P,Marschallinger J,Mrowetz H,Aigner L

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Sep 21 00:00:00 EDT 2018

Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung.

Frontiers in physiology

Lim D,Kim W,Lee C,Bae H,Kim J

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Plasmodium co-infection protects against chikungunya virus-induced pathologies.

Nature communications

Teo TH,Lum FM,Ghaffar K,Chan YH,Amrun SN,Tan JJL,Lee CYP,Chua TK,Carissimo G,Lee WWL,Claser C,Rajarethinam R,Rénia L,Ng LFP

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Sep 25 00:00:00 EDT 2018

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects.

Journal of experimental & clinical cancer research : CR

Xu L,Zhang Y,Tian K,Chen X,Zhang R,Mu X,Wu Y,Wang D,Wang S,Liu F,Wang T,Zhang J,Liu S,Zhang Y,Tu C,Liu H

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Oct 29 00:00:00 EDT 2018

Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice.

mSphere

Quach D,Collins F,Parameswaran N,McCabe L,Britton RA

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells.

Stem cell reports

Wang X,Dong F,Zhang S,Yang W,Yu W,Wang Z,Zhang S,Wang J,Ma S,Wu P,Gao Y,Dong J,Tang F,Cheng T,Ema H

13-0041 was used in Flow cytometry/Cell sorting to examine the effect of transforming growth factor Β1 on haematopoietic stem cell function.

Tue Jul 10 00:00:00 EDT 2018

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy.

Cell

Cabezas-Wallscheid N,Buettner F,Sommerkamp P,Klimmeck D,Ladel L,Thalheimer FB,Pastor-Flores D,Roma LP,Renders S,Zeisberger P,Przybylla A,Schönberger K,Scognamiglio R,Altamura S,Florian CM,Fawaz M,Vonficht D,Tesio M,Collier P,Pavlinic D,Geiger H,Schroeder T,Benes V,Dick TP,Rieger MA,Stegle O,Trumpp A

Thu May 18 00:00:00 EDT 2017

Store-Operated Ca²⁺ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.

Immunity

Vaeth M,Maus M,Klein-Hessling S,Freinkman E,Yang J,Eckstein M,Cameron S,Turvey SE,Serfling E,Berberich-Siebelt F,Possemato R,Feske S

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.

The Journal of clinical investigation

Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

The Journal of experimental medicine

Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Jun 05 00:00:00 EDT 2017

Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination.

Cancer research

Jiang H,Rivera-Molina Y,Gomez-Manzano C,Clise-Dwyer K,Bover L,Vence LM,Yuan Y,Lang FF,Toniatti C,Hossain MB,Fueyo J

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Sat Jul 15 00:00:00 EDT 2017

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

Proceedings of the National Academy of Sciences of the United States of America

Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Mar 21 00:00:00 EDT 2017

Pre/pro-B cells generate macrophage populations during homeostasis and inflammation.

Proceedings of the National Academy of Sciences of the United States of America

Audzevich T,Bashford-Rogers R,Mabbott NA,Frampton D,Freeman TC,Potocnik A,Kellam P,Gilroy DW

13-0041 was used in Flow cytometry/Cell sorting to study the developmental plasticity of immature B cells and their role as the source of tissue resident macrophages.

Tue May 16 00:00:00 EDT 2017

Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.

Acta pharmacologica Sinica

Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Cornea lymphatics drive the CD8⁺ T-cell response to herpes simplex virus-1.

Immunology and cell biology

Gurung HR,Carr MM,Carr DJ

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2017

ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.

RNA biology

Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu May 04 00:00:00 EDT 2017

Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery.

Scientific reports

Ai J,Li J,Gessler DJ,Su Q,Wei Q,Li H,Gao G

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunofluorescence

Mon Jan 09 00:00:00 EST 2017

Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated with Suppressed Inflammatory Transcriptional Networks in the Mouse Colon.

Frontiers in physiology

Yang T,Ahmari N,Schmidt JT,Redler T,Arocha R,Pacholec K,Magee KL,Malphurs W,Owen JL,Krane GA,Li E,Wang GP,Vickroy TW,Raizada MK,Martyniuk CJ,Zubcevic J

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunofluorescence

Thu Oct 01 00:00:00 EDT 2020

Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease.

Scientific reports

Ogawa Y,He H,Mukai S,Imada T,Nakamura S,Su CW,Mahabole M,Tseng SC,Tsubota K

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunohistochemistry

Mon Feb 06 00:00:00 EST 2017

Location of tumor affects local and distant immune cell type and number.

Immunity, inflammation and disease

Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Astaxanthin attenuates total body irradiation-induced hematopoietic system injury in mice via inhibition of oxidative stress and apoptosis.

Stem cell research & therapy

Xue XL,Han XD,Li Y,Chu XF,Miao WM,Zhang JL,Fan SJ

13-0041 was used in Flow cytometry/Cell sorting to suggest that ATX could be used as a potent therapeutic agent to protect the hematopoietic system against TBI-induced bone marrow suppression.

Mon Jan 23 00:00:00 EST 2017

Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury.

Stem cell research & therapy

Zhu D,Tan J,Maleken AS,Muljadi R,Chan ST,Lau SN,Elgass K,Leaw B,Mockler J,Chambers D,Leeman KT,Kim CF,Wallace EM,Lim R

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Nov 10 00:00:00 EST 2017

MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis.

Stem cell reports

Shigemoto-Kuroda T,Oh JY,Kim DK,Jeong HJ,Park SY,Lee HJ,Park JW,Kim TW,An SY,Prockop DJ,Lee RH

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue May 09 00:00:00 EDT 2017

Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mice by Selectively Altering the Gut Microbiota and Promoting Intestinal Gamma-Delta T Cells.

Frontiers in pharmacology

Li M,Gao J,Tang Y,Liu M,Wu S,Qu K,Long X,Li H,Liu M,Liu Y,Yuan J,Mao L,Liu Y,Zheng X,Wang E,Wang J,Yang Y

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies.

PloS one

Min M,Yan BX,Wang P,Landeck L,Chen JQ,Li W,Cai SQ,Zheng M,Man XY

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Jan 16 00:00:00 EST 2018

Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.

Oncoimmunology

Huang RY,Francois A,McGray AR,Miliotto A,Odunsi K

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.

JCI insight

Azzam KM,Madenspacher JH,Cain DW,Lai L,Gowdy KM,Rai P,Janardhan K,Clayton N,Cunningham W,Jensen H,Patel PS,Kearney JF,Taylor GA,Fessler MB

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Aug 17 00:00:00 EDT 2017

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.

Nature communications

Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Feb 13 00:00:00 EST 2017

A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation.

EBioMedicine

Ma J,Teng X,Wang X,Fan X,Wu Y,Tian M,Zhou Z,Li L

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Cell

Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Oct 06 00:00:00 EDT 2016

Foxp3 and Toll-like receptor signaling balance T_reg cell anabolic metabolism for suppression.

Nature immunology

Gerriets VA,Kishton RJ,Johnson MO,Cohen S,Siska PJ,Nichols AG,Warmoes MO,de Cubas AA,MacIver NJ,Locasale JW,Turka LA,Wells AD,Rathmell JC

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2016

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.

Nature cell biology

Pietras EM,Mirantes-Barbeito C,Fong S,Loeffler D,Kovtonyuk LV,Zhang S,Lakshminarasimhan R,Chin CP,Techner JM,Will B,Nerlov C,Steidl U,Manz MG,Schroeder T,Passegué E

13-0041 was used in Flow cytometry/Cell sorting to identify a critical regulatory circuit that tailors HSC responses to acute needs, and is likely to underlie deregulated blood homeostasis in chronic inflammation conditions.

Wed Jun 01 00:00:00 EDT 2016

NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells.

The Journal of experimental medicine

de Valle E,Grigoriadis G,O'Reilly LA,Willis SN,Maxwell MJ,Corcoran LM,Tsantikos E,Cornish JK,Fairfax KA,Vasanthakumar A,Febbraio MA,Hibbs ML,Pellegrini M,Banerjee A,Hodgkin PD,Kallies A,Mackay F,Strasser A,Gerondakis S,Gugasyan R

13-0041 was used in Flow cytometry/Cell sorting to identify a novel role of NFκB1 in preventing multiorgan autoimmunity through the negative regulation of Il-6 gene expression in follicular B cells.

Mon Apr 04 00:00:00 EDT 2016

CD8⁺ T cells drive autoimmune hematopoietic stem cell dysfunction and bone marrow failure.

Journal of autoimmunity

Gravano DM,Al-Kuhlani M,Davini D,Sanders PD,Manilay JO,Hoyer KK

13-0041 was used in Flow cytometry/Cell sorting to investigate whether CD8+ T cells play a non-redundant role in driving bone marrow failure.

Thu Dec 01 00:00:00 EST 2016

CD4 T Helper Cells Instruct Lymphopenia-Induced Memory-Like CD8 T Cells for Control of Acute LCMV Infection.

Frontiers in immunology

Schmitt ME,Sitte S,Voehringer D

13-0041 was used in Immunohistochemistry-immunofluorescence to determine whether memory-like T cells can efficiently respond to foreign antigen and participate in antiviral immunity.

Wed Nov 20 00:00:00 EST 2019

TCR Triggering Induces the Formation of Lck-RACK1-Actinin-1 Multiprotein Network Affecting Lck Redistribution.

Frontiers in immunology

Ballek O,Valečka J,Dobešová M,Broučková A,Manning J,Řehulka P,Stulík J,Filipp D

13-0041 was used in Magnetic cell separation to investigate the mechanism of membrane redistribution for Lck function.

Wed Nov 20 00:00:00 EST 2019

Macrophages are critical to the maintenance of IL-13-dependent lung inflammation and fibrosis.

Mucosal immunology

Borthwick LA,Barron L,Hart KM,Vannella KM,Thompson RW,Oland S,Cheever A,Sciurba J,Ramalingam TR,Fisher AJ,Wynn TA

13-0041 was used in Flow cytometry/Cell sorting to show that macrophages are required for the maintenance of type 2 immunity within affected tissues but not within secondary lymphoid organs.

Fri Jan 01 00:00:00 EST 2016

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.

Immunology

Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2016

p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.

European journal of immunology

Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

New mouse model of acute adult T-cell leukemia generated by transplantation of AKT, BCLxL, and HBZ-transduced T cells.

Cancer science

Kasugai Y,Yoshida N,Ohshima K,Matsuo K,Seto M,Tsuzuki S

13-0041 was used in Flow cytometry/Cell sorting to develop methods to explore the role of candidate genes with the HBZ gene in adult T-cell leukemia/lymphoma development, producing a new mouse model.

Mon Aug 01 00:00:00 EDT 2016

Multispectral Imaging of T and B Cells in Murine Spleen and Tumor.

Journal of immunology (Baltimore, Md. : 1950)

Feng Z,Jensen SM,Messenheimer DJ,Farhad M,Neuberger M,Bifulco CB,Fox BA

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunofluorescence

Sun May 01 00:00:00 EDT 2016

Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.

Journal of immunology (Baltimore, Md. : 1950)

Menendez CM,Jinkins JK,Carr DJ

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Aug 15 00:00:00 EDT 2016

Arrested Hematopoiesis and Vascular Relaxation Defects in Mice with a Mutation in Dhfr.

Molecular and cellular biology

Thoms JA,Knezevic K,Liu JJ,Glaros EN,Thai T,Qiao Q,Campbell H,Packham D,Huang Y,Papathanasiou P,Tunningley R,Whittle B,Yeung AW,Chandrakanthan V,Hesson L,Chen V,Wong JW,Purton LE,Ward RL,Thomas SR,Pimanda JE

13-0041 was used in Western Blotting to identify the genes involved in definitive hematopoiesis, and study the consequences of perturbing dihydrofolate reductase (DHFR) in vivo using a novel mouse model.

Fri Apr 01 00:00:00 EDT 2016

Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.

Molecular medicine reports

Gu L,Deng WS,Sun XF,Zhou H,Xu Q

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.

Biology open

Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Sun May 15 00:00:00 EDT 2016

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.

Nature communications

Brinkman CC,Iwami D,Hritzo MK,Xiong Y,Ahmad S,Simon T,Hippen KL,Blazar BR,Bromberg JS

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Jun 21 00:00:00 EDT 2016

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.

Nature communications

Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Jun 08 00:00:00 EDT 2016

p38 MAPK Inhibitor Insufficiently Attenuates HSC Senescence Administered Long-Term after 6 Gy Total Body Irradiation in Mice.

International journal of molecular sciences

Lu L,Wang YY,Zhang JL,Li DG,Meng AM

13-0041 was used in Flow cytometry/Cell sorting to investigate the effects of SB203580 on long-term TBI-induced myelosuppression.

Wed Jun 08 00:00:00 EDT 2016

Interleukin-10 deficiency impairs regulatory T cell-derived neuropilin-1 functions and promotes Th1 and Th17 immunity.

Scientific reports

Wang S,Gao X,Shen G,Wang W,Li J,Zhao J,Wei YQ,Edwards CK

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Apr 14 00:00:00 EDT 2016

NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.

Nature communications

Alrefai H,Muhammad K,Rudolf R,Pham DA,Klein-Hessling S,Patra AK,Avots A,Bukur V,Sahin U,Tenzer S,Goebeler M,Kerstan A,Serfling E

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed May 25 00:00:00 EDT 2016

Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice.

BMC complementary and alternative medicine

Zhang S,Liu X,Mei L,Wang H,Fang F

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Aug 31 00:00:00 EDT 2016

Flagellin is a strong vaginal adjuvant of a therapeutic vaccine for genital cancer.

Oncoimmunology

Lee SE,Hong SH,Verma V,Lee YS,Duong TN,Jeong K,Uthaman S,Sung YC,Lee JT,Park IK,Min JJ,Rhee JH

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2016

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms.

Cell reports

Choi IY,Piccio L,Childress P,Bollman B,Ghosh A,Brandhorst S,Suarez J,Michalsen A,Cross AH,Morgan TE,Wei M,Paul F,Bock M,Longo VD

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Jun 07 00:00:00 EDT 2016

TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection.

Cell reports

Schleicher U,Paduch K,Debus A,Obermeyer S,König T,Kling JC,Ribechini E,Dudziak D,Mougiakakos D,Murray PJ,Ostuni R,Körner H,Bogdan C

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue May 03 00:00:00 EDT 2016

Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.

Scientific reports

Ochi T,Feng Y,Kitamoto S,Nagao-Kitamoto H,Kuffa P,Atarashi K,Honda K,Teitelbaum DH,Kamada N

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Jun 15 00:00:00 EDT 2016

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Nature

Huang YH,Zhu C,Kondo Y,Anderson AC,Gandhi A,Russell A,Dougan SK,Petersen BS,Melum E,Pertel T,Clayton KL,Raab M,Chen Q,Beauchemin N,Yazaki PJ,Pyzik M,Ostrowski MA,Glickman JN,Rudd CE,Ploegh HL,Franke A,Petsko GA,Kuchroo VK,Blumberg RS

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Jan 15 00:00:00 EST 2015

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.

Nature biotechnology

Kim J,Li WA,Choi Y,Lewin SA,Verbeke CS,Dranoff G,Mooney DJ

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2015

Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner.

Blood

Yi W,Hu X,Chen Z,Liu L,Tian Y,Chen H,Cong YS,Yang F,Zhang L,Rudolph KL,Zhang Z,Zhao Y,Ju Z

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Jul 30 00:00:00 EDT 2015

Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis.

Circulation research

Ye YX,Calcagno C,Binderup T,Courties G,Keliher EJ,Wojtkiewicz GR,Iwamoto Y,Tang J,Pérez-Medina C,Mani V,Ishino S,Johnbeck CB,Knigge U,Fayad ZA,Libby P,Weissleder R,Tawakol A,Dubey S,Belanger AP,Di Carli MF,Swirski FK,Kjaer A,Mulder WJ,Nahrendorf M

13-0041 was used in Flow cytometry/Cell sorting to perform (18)F-FLT positron emission tomography-computed tomography was performed in mice, rabbits, and humans with atherosclerosis.

Fri Oct 23 00:00:00 EDT 2015

Distinct germinal center selection at local sites shapes memory B cell response to viral escape.

The Journal of experimental medicine

Adachi Y,Onodera T,Yamada Y,Daio R,Tsuiji M,Inoue T,Kobayashi K,Kurosaki T,Ato M,Takahashi Y

13-0041 was used in Magnetic cell separation to investigate the cellular events dictating the cross-reactive memory B cell responses, showing that distinct germinal center selection at local sites shapes response to viral escape.

Mon Sep 21 00:00:00 EDT 2015

IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.

The Journal of experimental medicine

Pallangyo CK,Ziegler PK,Greten FR

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Dec 14 00:00:00 EST 2015

Depletion of B cells induces remission of autoimmune hepatitis in mice through reduced antigen presentation and help to T cells.

Hepatology (Baltimore, Md.)

Béland K,Marceau G,Labardy A,Bourbonnais S,Alvarez F

13-0041 was used in Immunohistochemistry-immunofluorescence to study the immunological changes underlying the autoimmune hepatitis remission caused by B-cell depletion in an experimental model of AIH.

Sun Nov 01 00:00:00 EDT 2015

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Developmental cell

Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Sep 14 00:00:00 EDT 2015

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Developmental cell

Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Sep 14 00:00:00 EDT 2015

B cell autophagy mediates TLR7-dependent autoimmunity and inflammation.

Autophagy

Weindel CG,Richey LJ,Bolland S,Mehta AJ,Kearney JF,Huber BT

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunohistochemistry

Mon Apr 18 00:00:00 EDT 2016

IFN-γ ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation.

Proceedings of the National Academy of Sciences of the United States of America

Sosa RA,Murphey C,Robinson RR,Forsthuber TG

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunofluorescence

Tue Sep 08 00:00:00 EDT 2015

Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.

Cell death and differentiation

Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice.

Free radical biology & medicine

Xu G,Wu H,Zhang J,Li D,Wang Y,Wang Y,Zhang H,Lu L,Li C,Huang S,Xing Y,Zhou D,Meng A

13-0041 was used in Flow cytometry/Cell sorting to study how metformin has the potential to be used as a novel radioprotectant to ameliorate TBI-induced long-term BM injury.

Thu Oct 01 00:00:00 EDT 2015

Mice lacking Axl and Mer tyrosine kinase receptors are susceptible to experimental autoimmune orchitis induction.

Immunology and cell biology

Li N,Liu Z,Zhang Y,Chen Q,Liu P,Cheng CY,Lee WM,Chen Y,Han D

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2015

B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses.

Journal of immunology (Baltimore, Md. : 1950)

Pone EJ,Lam T,Lou Z,Wang R,Chen Y,Liu D,Edinger AL,Xu Z,Casali P

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2015

Histone deacetylation of memory T lymphocytes by You-Gui-Wan alleviates allergen-induced eosinophilic airway inflammation in asthma.

Chinese medicine

Zhang HP,Fu JJ,Fan T,Zhang WB,Wang ZL,Wang L,Wang G

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Jun 15 00:00:00 EDT 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Sep 15 00:00:00 EDT 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Sep 15 00:00:00 EDT 2015

Mannan-modified adenovirus targeting TERT and VEGFR-2: A universal tumour vaccine.

Scientific reports

Wang Y,Zhang J,Wu Y,Ding ZY,Luo XM,Liu J,Zhong WN,Deng GH,Xia XY,Deng YT,Wei YQ,Jiang Y

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Jun 18 00:00:00 EDT 2015

Intranasal Administration of Lentiviral miR-135a Regulates Mast Cell and Allergen-Induced Inflammation by Targeting GATA-3.

PloS one

Deng YQ,Yang YQ,Wang SB,Li F,Liu MZ,Hua QQ,Tao ZZ

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue May 31 00:00:00 EDT 2016

Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses.

Stem cell reports

Wang WB,Yen ML,Liu KJ,Hsu PJ,Lin MH,Chen PM,Sudhir PR,Chen CH,Chen CH,Sytwu HK,Yen BL

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Sep 08 00:00:00 EDT 2015

Disease severity and mortality can be independently regulated in a mouse model of experimental graft versus host disease.

PloS one

Galvani RG,Lemos R,Areal RB,Salvador PA,Zamboni DS,Wanderley JL,Bonomo A

13-0041 was used in Magnetic cell separation to investigate the exact cause of death in graft versus host disease, showing that disease severity and mortality can be independently regulated.

Mon Oct 19 00:00:00 EDT 2015

CCR10 regulates balanced maintenance and function of resident regulatory and effector T cells to promote immune homeostasis in the skin.

The Journal of allergy and clinical immunology

Xia M,Hu S,Fu Y,Jin W,Yi Q,Matsui Y,Yang J,McDowell MA,Sarkar S,Kalia V,Xiong N

13-0041 was used in Flow cytometry/Cell sorting to investigate the functional importance of CCR10/CCL27 in vivo, showing that CCR10 regulates maintenance and function of regulatory and effector T cells to promote immune homeostasis.

Mon Sep 01 00:00:00 EDT 2014

Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.

Autophagy

Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Jul 01 00:00:00 EDT 2014

Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.

PLoS pathogens

Ataide MA,Andrade WA,Zamboni DS,Wang D,Souza Mdo C,Franklin BS,Elian S,Martins FS,Pereira D,Reed G,Fitzgerald KA,Golenbock DT,Gazzinelli RT

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2014

Regulation of cyp26a1 on Th17 cells in mouse peri-implantation.

Journal of cellular and molecular medicine

Liu HY,Chao H,Liu ZK,Xia HF,Song Z,Yang Y,Peng JP

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Sat Mar 01 00:00:00 EST 2014

Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.

Human vaccines & immunotherapeutics

Wang S,Wu B,Xue J,Wang M,Chen R,Wang B

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Jan 05 00:00:00 EST 2015

High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Somatostatin inhibits the production of interferon-γ by intestinal epithelial cells during intestinal ischemia-reperfusion in macaques.

Digestive diseases and sciences

Liu L,Tan Q,Hu B,Wu H,Wang C,Tang C

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunohistochemistry

Wed Oct 01 00:00:00 EDT 2014

Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects.

BMC cancer

Tian H,Shi G,Yang G,Zhang J,Li Y,Du T,Wang J,Xu F,Cheng L,Zhang X,Dai L,Chen X,Zhang S,Yang Y,Yu D,Wei Y,Deng H

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Jan 29 00:00:00 EST 2014

Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects.

BMC cancer

Tian H,Shi G,Yang G,Zhang J,Li Y,Du T,Wang J,Xu F,Cheng L,Zhang X,Dai L,Chen X,Zhang S,Yang Y,Yu D,Wei Y,Deng H

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Jan 29 00:00:00 EST 2014

A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking β-glucans.

PloS one

Dong B,Li D,Li R,Chen SC,Liu W,Liu W,Chen L,Chen Y,Zhang X,Tong Z,Xia Y,Xia P,Wang Y,Duan Y

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2015

Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.

Development (Cambridge, England)

Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2013

A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).

Disease models & mechanisms

Carofino BL,Ayanga B,Justice MJ

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Nov 01 00:00:00 EDT 2013

Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice.

Human vaccines & immunotherapeutics

Wu B,Zou Q,Hu Y,Wang B

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2013

Inhibiting TGFβ1 has a protective effect on mouse bone marrow suppression following ionizing radiation exposure in vitro.

Journal of radiation research

Zhang H,Wang YA,Meng A,Yan H,Wang X,Niu J,Li J,Wang H

13-0041 was used in Flow cytometry/Cell sorting to examine if the TGF1 inhibitor, SB431542, can mitigate ionizing radiation-induced bone marrow suppression, showing that inhibition has a protective effect.

Mon Jul 01 00:00:00 EDT 2013

The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine.

PloS one

Radulovic K,Rossini V,Manta C,Holzmann K,Kestler HA,Niess JH

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunofluorescence

Thu Jan 23 00:00:00 EST 2014

The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine.

PloS one

Radulovic K,Rossini V,Manta C,Holzmann K,Kestler HA,Niess JH

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunofluorescence

Thu Jan 23 00:00:00 EST 2014

Enhanced immune response against HIV-1 induced by a heterologous DNA prime-adenovirus boost vaccination using mannosylated polyethyleneimine as DNA vaccine adjuvant.

International journal of nanomedicine

Li M,Jiang Y,Xu C,Zhang Z,Sun X

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Wed Apr 02 00:00:00 EDT 2014

Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.

PloS one

Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Jul 31 00:00:00 EDT 2014

Thymus-autonomous T cell development in the absence of progenitor import.

The Journal of experimental medicine

Martins VC,Ruggiero E,Schlenner SM,Madan V,Schmidt M,Fink PJ,von Kalle C,Rodewald HR

13-0041 was used in Flow cytometry/Cell sorting to characterise the previously unrecognised capacity of the thymus to sustain T cell development during bone marrow progenitor deprivation.

Mon Jul 30 00:00:00 EDT 2012

Cell type-specific targeting dissociates the therapeutic from the adverse effects of protein kinase inhibition in allergic skin disease.

Proceedings of the National Academy of Sciences of the United States of America

Ritprajak P,Hayakawa M,Sano Y,Otsu K,Park JM

13-0041 was used in Magnetic cell separation to show that the effect of interfering with p38α signalling can be either therapeutic or adverse depending on the targeted cell type.

Tue Jun 05 00:00:00 EDT 2012

Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.

PloS one

Gong Y,Wang Z,Liang Z,Duan H,Ouyang L,Yu Q,Xu Z,Shen G,Weng X,Wu X

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Fri Jul 19 00:00:00 EDT 2013

Opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor generate T helper 1 central and effector memory cells.

Immunity

Pepper M,Pagán AJ,Igyártó BZ,Taylor JJ,Jenkins MK

13-0041 was used in Functional assays to study the generation of T helper 1 central and effector memory cells from opposing signals from the Bcl6 transcription factor and the interleukin-2 receptor.

Fri Oct 28 00:00:00 EDT 2011

Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion.

Circulation

Itoh S,Kimura N,Axtell RC,Velotta JB,Gong Y,Wang X,Kajiwara N,Nambu A,Shimura E,Adachi H,Iwakura Y,Saito H,Okumura K,Sudo K,Steinman L,Robbins RC,Nakae S,Fischbein MP

13-0041 was used in Flow cytometry/Cell sorting to investigate the role of interleukin-17 in acute allograft rejection.

Tue Sep 13 00:00:00 EDT 2011

Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis.

Blood

Libregts SF,Gutiérrez L,de Bruin AM,Wensveen FM,Papadopoulos P,van Ijcken W,Ozgür Z,Philipsen S,Nolte MA

13-0041 was used in Flow cytometry/Cell sorting to reveal a molecular mechanism by which chronic exposure to IFN-γ induces expression of IRF-1 and ultimately induces anaemia.

Thu Sep 01 00:00:00 EDT 2011

Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.

The EMBO journal

Sela M,Bogin Y,Beach D,Oellerich T,Lehne J,Smith-Garvin JE,Okumura M,Starosvetsky E,Kosoff R,Libman E,Koretzky G,Kambayashi T,Urlaub H,Wienands J,Chernoff J,Yablonski D

13-0041 was used in Functional assays to identify and determine the function of SLP-76 phosphorylation site Y173.

Fri Jul 01 00:00:00 EDT 2011

Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle.

Molecular medicine (Cambridge, Mass.)

Eghtesad S,Jhunjhunwala S,Little SR,Clemens PR

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunohistochemistry

Sun Mar 25 00:00:00 EDT 2012

T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.

Journal of immunology (Baltimore, Md. : 1950)

Wang R,Xie H,Huang Z,Ma J,Fang X,Ding Y,Sun Z

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2011

Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity.

Gene therapy

Eghtesad S,Zheng H,Nakai H,Epperly MW,Clemens PR

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Immunohistochemistry

Wed Sep 01 00:00:00 EDT 2010

Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals.

Nature immunology

Derudder E,Cadera EJ,Vahl JC,Wang J,Fox CJ,Zha S,van Loo G,Pasparakis M,Schlissel MS,Schmidt-Supprian M,Rajewsky K

13-0041 was used in Magnetic cell separation to define two distinct, consecutive phases of early B cell development that differ in their dependence on IKK-mediated NF-kappaB signaling.

Mon Jun 01 00:00:00 EDT 2009

c-Myb is required for pro-B cell differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Fahl SP,Crittenden RB,Allman D,Bender TP

13-0041 was used in Flow cytometry/Cell sorting to demonstrate that c-Myb is absolutely required for the survival and differentiation of CD19(+) B-lineage cells.

Sun Nov 01 00:00:00 EDT 2009

Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.

Investigative ophthalmology & visual science

Mochimaru H,Usui T,Yaguchi T,Nagahama Y,Hasegawa G,Usui Y,Shimmura S,Tsubota K,Amano S,Kawakami Y,Ishida S

Thu May 01 00:00:00 EDT 2008

Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.

Circulation

Yang Z,Day YJ,Toufektsian MC,Xu Y,Ramos SI,Marshall MA,French BA,Linden J

Tue Nov 07 00:00:00 EST 2006

Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors.

Blood

Zhang J,Raper A,Sugita N,Hingorani R,Salio M,Palmowski MJ,Cerundolo V,Crocker PR

13-0041 was used in Immunofluorescence to analyse the cellular expression pattern and functional properties of Siglec-H.

Mon May 01 00:00:00 EDT 2006

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis.

Proceedings of the National Academy of Sciences of the United States of America

Woolf E,Xiao C,Fainaru O,Lotem J,Rosen D,Negreanu V,Bernstein Y,Goldenberg D,Brenner O,Berke G,Levanon D,Groner Y

Published figure using CD4 monoclonal antibody (Product # 13-0041-82) in Flow Cytometry

Tue Jun 24 00:00:00 EDT 2003

Bioinformatics

Protein Aliases: CD4; CD4 antigen p55; cd4a; fCD4; Leu-3; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4)

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Gene Aliases: Cd4; L3T4; Ly-4

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UniProt ID: (Mouse) P06332

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Entrez Gene ID: (Mouse) 12504

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Function(s)

glycoprotein binding protein binding zinc ion binding coreceptor activity enzyme binding protein kinase binding protein homodimerization activity

Process(es)

cytokine production immune system process induction by virus of host cell-cell fusion immune response cell adhesion cell surface receptor signaling pathway T cell differentiation maintenance of protein location in cell T cell activation T cell selection protein palmitoleylation positive regulation of protein kinase activity positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-negative bacterium positive regulation of calcium-mediated signaling regulation of T cell activation positive regulation of T cell activation

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CD4 Monoclonal Antibody (GK1.5), Biotin, eBioscience™

CD4 Antibody (13-0041-82) in Flow

Product Details

13-0041-82

Immunohistochemistry (IHC)

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Functional Assay (Functional)

Miscellaneous PubMed (Misc)

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Recommended Isotype Control

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