Product References
Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response.
Cell reports
Hu Q,Xu T,Zhang M,Zhang H,Liu Y,Li HB,Chen C,Zheng J,Zhang Z,Li F,Shen N,Zhang W,Melnick A,Huang C
17-0041-82 was used in Flow cytometry/Cell sorting to reveal that differential dynamics of Bach2 protein and transcripts in activated B cells control their cell-fate outcomes and imprint the fates of their descendant effector cells.
Tue Jul 05 00:00:00 EDT 2022
Transient Systemic Autophagy Inhibition Is Selectively and Irreversibly Deleterious to Lung Cancer.
Cancer research
Khayati K,Bhatt V,Lan T,Alogaili F,Wang W,Lopez E,Hu ZS,Gokhale S,Cassidy L,Narita M,Xie P,White E,Guo JY
17-0041-82 was used in Flow Cytometry to generate reversible tumor-specific and systemic autophagy loss mouse models of KrasG12D/+;p53-/- (KP) non-small cell lung cancer (NSCLC).
Fri Dec 02 00:00:00 EST 2022
Ex Vivo and In Vitro Methods for Detection of Bioactive Staphylococcal Enterotoxins.
Methods in molecular biology (Clifton, N.J.)
Rasooly R,Do P,Hernlem B
17-0041-82 was used in Flow cytometry/Cell sorting to investigate detection methods for Staphylococcal enterotoxins.
Wed Jan 19 00:00:00 EST 2022
Multifaceted modes of action of the anticancer probiotic Enterococcus hirae.
Cell death and differentiation
Goubet AG,Wheeler R,Fluckiger A,Qu B,Lemaître F,Iribarren K,Mondragón L,Tidjani Alou M,Pizzato E,Durand S,Derosa L,Aprahamian F,Bossut N,Moya-Nilges M,Derrien D,Chen G,Leduc M,Joseph A,Pons N,Le Chatelier E,Segata N,Yonekura S,Iebba V,Kepp O,Raoult D,André F,Kroemer G,Boneca IG,Zitvogel L,Daillère R
17-0041-82 was used in Flow cytometry/Cell sorting to surmise that immunological, metabolic, epithelial, and microbial modes of action of the live E. hirae cooperate to circumvent primary resistance to therapy.
Thu Jul 01 00:00:00 EDT 2021
Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ.
Aging cell
Webb LMC,Fra-Bido S,Innocentin S,Matheson LS,Attaf N,Bignon A,Novarino J,Fazilleau N,Linterman MA
17-0041-82 was used in Flow Cytometry to show increased formation of Tfh precursors (pre-Tfh) but no associated increase in germinal centre (GC)-Tfh cells in aged mice, suggesting age-driven promotion of only early Tfh cell differentiation.
Fri Jan 01 00:00:00 EST 2021
Peptidylprolyl isomerase C (Ppic) regulates invariant Natural Killer T cell (iNKT) differentiation in mice.
European journal of immunology
Paiva RS,Ramos CV,Azenha SR,Alves C,Basto AP,Graca L,Martins VC
17-0041-82 was used in Flow Cytometry to show that Ppic is dispensable for myeloid cells, platelets, erythrocytes, αβ and γδ T lymphocytes in vivo in the steady state, while being involved in B and iNKT cell differentiation.
Sun Aug 01 00:00:00 EDT 2021
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Nature communications
Yang Z,Xu G,Wang B,Liu Y,Zhang L,Jing T,Tang M,Xu X,Jiao K,Xiang L,Fu Y,Tang D,Zhang X,Jin W,Zhuang G,Zhao X,Liu Y
17-0041-82 was used in Flow Cytometry to show that the deubiquitinase USP12 is commonly downregulated in the KrasG12D-driven mouse lung tumour and human non-small cell lung cancer owing to the activation of AKT-mTOR signalling.
Wed Aug 11 00:00:00 EDT 2021
Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology.
Science advances
Da Mesquita S,Herz J,Wall M,Dykstra T,de Lima KA,Norris GT,Dabhi N,Kennedy T,Baker W,Kipnis J
17-0041 was used in Flow cytometry/Cell sorting to test a hypothesis that an age-related reduction in C-C chemokine receptor type 7 (CCR7)-dependent egress of immune cells through the lymphatic vasculature mediates some aspects of brain aging and potentially exacerbates cognitive decline and Alzheimer's disease-like brain β-amyloid (Aβ) pathology.
Sat May 01 00:00:00 EDT 2021
Systemic Delivery of Oncolytic Adenovirus to Tumors Using Tumor-Infiltrating Lymphocytes as Carriers.
Cells
Santos J,Heiniö C,Quixabeira D,Zafar S,Clubb J,Pakola S,Cervera-Carrascon V,Havunen R,Kanerva A,Hemminki A
17-0041-82 was used in Flow Cytometry to show in vivo in different models that virus could be delivered to tumors with TILs as carriers.
Thu Apr 22 00:00:00 EDT 2021
Systemic Delivery of Oncolytic Adenovirus to Tumors Using Tumor-Infiltrating Lymphocytes as Carriers.
Cells
Santos J,Heiniö C,Quixabeira D,Zafar S,Clubb J,Pakola S,Cervera-Carrascon V,Havunen R,Kanerva A,Hemminki A
17-0041-82 was used in Flow Cytometry to show in vivo in different models that virus could be delivered to tumors with TILs as carriers.
Thu Apr 22 00:00:00 EDT 2021
Plasmacytoid Dendritic Cells and Type I Interferon Promote Extrafollicular B Cell Responses to Extracellular Self-DNA.
Immunity
Soni C,Perez OA,Voss WN,Pucella JN,Serpas L,Mehl J,Ching KL,Goike J,Georgiou G,Ippolito GC,Sisirak V,Reizis B
17-0041-82 was used in Flow Cytometry to establish extrafollicular B cell differentiation into short-lived AFCs as a key mechanism of anti-DNA autoreactivity and reveal a major contribution of pDCs, endosomal Toll-like receptors (TLRs), and IFN-I to this pathway.
Tue Jun 16 00:00:00 EDT 2020
Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.
Immunity
Lou F,Sun Y,Xu Z,Niu L,Wang Z,Deng S,Liu Z,Zhou H,Bai J,Yin Q,Cai X,Sun L,Wang H,Li Q,Wu Z,Chen X,Gu J,Shi YL,Tao W,Ginhoux F,Wang H
17-0041-82 was used in Flow Cytometry to suggest that urea cycle hyperreactivity and excessive polyamine generation in psoriatic keratinocytes promote self-RNA sensation and PP6 deregulation in keratinocytes is a pivotal event that amplifies the inflammatory circuits in psoriasis.
Tue Jul 14 00:00:00 EDT 2020
An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.
Immunity
Chopp LB,Gopalan V,Ciucci T,Ruchinskas A,Rae Z,Lagarde M,Gao Y,Li C,Bosticardo M,Pala F,Livak F,Kelly MC,Hannenhalli S,Bosselut R
17-0041-82 was used in Flow Cytometry to identify mouse and human αβ thymocyte developmental trajectories.
Tue Dec 15 00:00:00 EST 2020
An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.
Immunity
Chopp LB,Gopalan V,Ciucci T,Ruchinskas A,Rae Z,Lagarde M,Gao Y,Li C,Bosticardo M,Pala F,Livak F,Kelly MC,Hannenhalli S,Bosselut R
17-0041-82 was used in Flow Cytometry to identify mouse and human αβ thymocyte developmental trajectories.
Tue Dec 15 00:00:00 EST 2020
Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response.
Cancer cell
Béguelin W,Teater M,Meydan C,Hoehn KB,Phillip JM,Soshnev AA,Venturutti L,Rivas MA,Calvo-Fernández MT,Gutierrez J,Camarillo JM,Takata K,Tarte K,Kelleher NL,Steidl C,Mason CE,Elemento O,Allis CD,Kleinstein SH,Melnick AM
17-0041 was used in Flow cytometry/Cell sorting to show that EZH2 mutations initiate FL by attenuating germinal center(GC) B cell requirement for T cell help and driving slow expansion of GC centrocytes that become enmeshed with and dependent on follicular dendritic cells.
Mon May 11 00:00:00 EDT 2020
BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse.
Cell stem cell
Jia L,Zhang W,Wang CY
17-0041-82 was used in Flow Cytometry to suggest that targeting BMI1 may enable immune checkpoint blockade to inhibit metastatic tumor growth and prevent tumor relapse by activating cell-intrinsic immunity, in addition to purging CSCs.
Thu Aug 06 00:00:00 EDT 2020
Dynamic regulation of chromatin organizer SATB1 via TCR-induced alternative promoter switch during T-cell development.
Nucleic acids research
Patta I,Madhok A,Khare S,Gottimukkala KP,Verma A,Giri S,Dandewad V,Seshadri V,Lal G,Misra-Sen J,Galande S
17-0041 was used in Flow cytometry/Cell sorting to study the mechanism regulating expression of SATB1 during T-cell development.
Fri Jun 19 00:00:00 EDT 2020
ILC2s are the predominant source of intestinal ILC-derived IL-10.
The Journal of experimental medicine
Bando JK,Gilfillan S,Di Luccia B,Fachi JL,Sécca C,Cella M,Colonna M
17-0041 was used in Flow cytometry/Cell sorting to report the absence of an intestinal regulatory ILC population distinct from group 1 ILCs (ILC1s), ILC2s, and ILC3s in (1) mice bred in our animal facility; (2) mice from The Jackson Laboratory, Taconic Biosciences, and Charles River Laboratories; and (3) mice subjected to intestinal inflammation.
Mon Feb 03 00:00:00 EST 2020
Contact-dependent delivery of IL-2 by dendritic cells to CD4 T cells in the contraction phase promotes their long-term survival.
Protein & cell
Tong D,Zhang L,Ning F,Xu Y,Hu X,Shi Y
17-0041-82 was used in Flow Cytometry to report here that resting, previously antigen-stimulated CD4 T cells maintain a minimalist response to dendritic cells after their peak activation in vitro.
Sat Feb 01 00:00:00 EST 2020
Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer.
Cell death and differentiation
Nguyen PM,Dagley LF,Preaudet A,Lam N,Giam M,Fung KY,Aizel K,van Duijneveldt G,Tan CW,Hirokawa Y,Yip HYK,Love CG,Poh AR,Cruz A,Burstroem C,Feltham R,Abdirahman SM,Meiselbach K,Low RRJ,Palmieri M,Ernst M,Webb AI,Burgess T,Sieber OM,Bouillet P,Putoczki TL
17-0041-82 was used in Flow Cytometry to study a role for Bcl-G in colon cancer.
Sat Feb 01 00:00:00 EST 2020
Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Elsayed R,Kurago Z,Cutler CW,Arce RM,Gerber J,Celis E,Sultan H,Elashiry M,Meghil M,Sun C,Auersvald CM,Awad ME,Zeitoun R,Elsayed R,Eldin M Elshikh M,Isales C,Elsalanty ME
17-0041-82 was used in Flow Cytometry to conclude that the mechanism of Zol-induced osteonecrosis of the jaw involves disruption of DC immune functions required to clear bacterial infection and activate T cell effector response.
Sat Feb 01 00:00:00 EST 2020
Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Elsayed R,Kurago Z,Cutler CW,Arce RM,Gerber J,Celis E,Sultan H,Elashiry M,Meghil M,Sun C,Auersvald CM,Awad ME,Zeitoun R,Elsayed R,Eldin M Elshikh M,Isales C,Elsalanty ME
17-0041-82 was used in Flow Cytometry to conclude that the mechanism of Zol-induced osteonecrosis of the jaw involves disruption of DC immune functions required to clear bacterial infection and activate T cell effector response.
Sat Feb 01 00:00:00 EST 2020
MiR-1165-3p Suppresses Th2 Differentiation via Targeting IL-13 and PPM1A in a Mouse Model of Allergic Airway Inflammation.
Allergy, asthma & immunology research
Wang Z,Ji N,Chen Z,Sun Z,Wu C,Yu W,Hu F,Huang M,Zhang M
17-0041 was used in Flow cytometry/Cell sorting to investigate the associations between Th2 differentiation and miR-1165b-3p in asthma as well as the possible mechanisms.
Tue Sep 01 00:00:00 EDT 2020
Adipose tissue dendritic cell signals are required to maintain T cell homeostasis and obesity-induced expansion.
Molecular and cellular endocrinology
Porsche CE,Delproposto JB,Patrick E,Zamarron BF,Lumeng CN
17-0041 was used in Flow cytometry/Cell sorting to investigate the contribution of dendritic cells to adipose tissue derived chronic inflammation as professional antigen presenting cells in adipose issue.
Sun Apr 05 00:00:00 EDT 2020
Mesenchymal stem cells protect against malaria pathogenesis by reprogramming erythropoiesis in the bone marrow.
Cell death discovery
Thakur RS,Awasthi V,Sanyal A,Chatterjee S,Rani S,Chauhan R,Kalkal M,Tiwari M,Pande V,Das J
17-0041 was used in Flow cytometry/Cell sorting to suggest that MSCs play a critical role in host protection against malaria infection by modulating erythropoiesis and lymphopoiesis.
Sun Nov 15 00:00:00 EST 2020
Lactate Limits T Cell Proliferation via the NAD(H) Redox State.
Cell reports
Quinn WJ,Jiao J,TeSlaa T,Stadanlick J,Wang Z,Wang L,Akimova T,Angelin A,Schäfer PM,Cully MD,Perry C,Kopinski PK,Guo L,Blair IA,Ghanem LR,Leibowitz MS,Hancock WW,Moon EK,Levine MH,Eruslanov EB,Wallace DC,Baur JA,Beier UH
17-0041-82 was used in Flow Cytometry to show that the nicotinamide adenine dinucleotide (NAD) redox state controls T cell glycolysis via glyceraldehyde 3-phosphate dehydrogenase (GAPDH), as well as glucose-derived serine production.
Tue Dec 15 00:00:00 EST 2020
Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells.
Cell reports
Morelli AE,Sumpter TL,Rojas-Canales DM,Bandyopadhyay M,Chen Z,Tkacheva O,Shufesky WJ,Wallace CT,Watkins SC,Berger A,Paige CJ,Falo LD,Larregina AT
17-0041 was used in Flow cytometry/Cell sorting to demonstrate an effect of the NK1R in T cells that is relevant for immunotherapies based on pro-inflammatory neuropeptides and its receptors.
Tue Mar 10 00:00:00 EDT 2020
Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross.
Cell reports
Martin MD,Sompallae R,Winborn CS,Harty JT,Badovinac VP
17-0041 was used in Flow cytometry/Cell sorting to advance the utility of the Collaborative Cross (CC) as a tool to analyze the immune response to viral infection.
Tue Apr 14 00:00:00 EDT 2020
Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response.
Nature cancer
Poillet-Perez L,Sharp DW,Yang Y,Laddha SV,Ibrahim M,Bommareddy PK,Hu ZS,Vieth J,Haas M,Bosenberg MW,Rabinowitz JD,Cao J,Guan JL,Ganesan S,Chan CS,Mehnert JM,Lattime EC,White E
17-0041-82 was used in Flow Cytometry to study autophagy promotion of tumor immune tolerance in regulating T-cell function and limiting interferon gene stimulation.
Tue Sep 01 00:00:00 EDT 2020
Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function.
Frontiers in immunology
Wang A,Yang M,Liang R,Zhu F,Zhu F,Liu X,Han Y,Lin R,Wang X,Li D,Li H,Yuan X,Zhao H,Li B
17-0041 was used in Flow cytometry/Cell sorting to investigate how mouse double minute 2 homolog effects the function of regulatory T cells.
Mon Apr 05 00:00:00 EDT 2021
Treatment and Prevention of Lung Cancer Using a Virus-Infected Reprogrammed Somatic Cell-Derived Tumor Cell Vaccination (VIReST) Regime.
Frontiers in immunology
Zhang Z,Lu S,Dunmall LSC,Wang Z,Cheng Z,Zhang Z,Yan W,Chu Y,Gao D,Wang N,Li Y,Wang J,Li Y,Ji Y,Shan D,Li K,Wang P,Dong Y,Dong J,Lemoine NR,Pei D,Zhang L,Wang Y
17-0041 was used in Flow cytometry/Cell sorting to establish how a Virus-Infected Reprogrammed Somatic cell-derived Tumor cell (VIReST) vaccination regime can be utilised for treatment or prevention of lung cancer development in at-risk individuals.
Fri Apr 30 00:00:00 EDT 2021
IFN-γ promoted exosomes from mesenchymal stem cells to attenuate colitis via miR-125a and miR-125b.
Cell death & disease
Yang R,Huang H,Cui S,Zhou Y,Zhang T,Zhou Y
17-0041-82 was used in Flow Cytometry to investigate the potential anti-inflammatory effects of bone marrow mesenchymal stem cell-derived exosomes.
Thu Jul 30 00:00:00 EDT 2020
Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer.
Immunity
Dmitrieva-Posocco O,Dzutsev A,Posocco DF,Hou V,Yuan W,Thovarai V,Mufazalov IA,Gunzer M,Shilovskiy IP,Khaitov MR,Trinchieri G,Waisman A,Grivennikov SI
17-0041-82 was used in Flow Cytometry to examine the impact of IL-1 signaling, a key regulator of the IL-17 pathway, in different cell types within the CRC microenvironment.
Tue Jan 15 00:00:00 EST 2019
Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.
Cell host & microbe
Gogokhia L,Buhrke K,Bell R,Hoffman B,Brown DG,Hanke-Gogokhia C,Ajami NJ,Wong MC,Ghazaryan A,Valentine JF,Porter N,Martens E,O'Connell R,Jacob V,Scherl E,Crawford C,Stephens WZ,Casjens SR,Longman RS,Round JL
17-0041 was used in Flow cytometry/Cell sorting to indicate that bacteriophages can alter mucosal immunity to impact mammalian health.
Wed Feb 13 00:00:00 EST 2019
Localized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity against Disseminated Subcutaneous and Intracranial Melanomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Jiang H,Shin DH,Nguyen TT,Fueyo J,Fan X,Henry V,Carrillo CC,Yi Y,Alonso MM,Collier TL,Yuan Y,Lang FF,Gomez-Manzano C
17-0041 was used in Flow cytometry/Cell sorting to show that localized intratumoral injection of Delta-24-RGDOX induces an in situ antovaccination of the treated melanoma, the effect of which changes the immune landscape of the treated mice, resulting in systemic immunity against disseminated s.c. and i.c. tumors.
Fri Nov 15 00:00:00 EST 2019
Blocking meningeal lymphatic drainage aggravates Parkinson's disease-like pathology in mice overexpressing mutated α-synuclein.
Translational neurodegeneration
Zou W,Pu T,Feng W,Lu M,Zheng Y,Du R,Xiao M,Hu G
17-0041 was used in Flow cytometry/Cell sorting to suggest that brain lymphatic clearance dysfunction may be an aggravating factor in PD pathology.
Fri Apr 08 00:00:00 EDT 2022
Persistent Malfunction of Glymphatic and Meningeal Lymphatic Drainage in a Mouse Model of Subarachnoid Hemorrhage.
Experimental neurobiology
Pu T,Zou W,Feng W,Zhang Y,Wang L,Wang H,Xiao M
17-0041-82 was used in Flow Cytometry to demonstrate persistent malfunction of glymphatic and meningeal lymphatic drainage and related neuropathological damages after SAH.
Fri Feb 01 00:00:00 EST 2019
Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation.
Science advances
Lee YS,Riopel M,Cabrales P,Bandyopadhyay GK
17-0041-82 was used in Flow Cytometry to understand obesity-induced changes in liver oxygen homeostasis and find that liver HIF-1α expression was increased mainly by soluble factors released from obese adipocytes, leading to decreased incretin effects.
Mon Jul 01 00:00:00 EDT 2019
An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses.
NPJ vaccines
Li G,Adam A,Luo H,Shan C,Cao Z,Fontes-Garfias CR,Sarathy VV,Teleki C,Winkelmann ER,Liang Y,Sun J,Bourne N,Barrett ADT,Shi PY,Wang T
17-0041-82 was used in Flow cytometry/Cell sorting to suggest that the ZIKV NS4B-C100S mutant may serve as a candidate ZIKV LAV due to its attenuated phenotype and high immunogenicity.
Thu Oct 01 00:00:00 EDT 2020
Next Generation Sequencing for Long Non-coding RNAs Profile for CD4+ T Cells in the Mouse Model of Acute Asthma.
Frontiers in genetics
Wang Z,Ji N,Chen Z,Wu C,Sun Z,Yu W,Hu F,Huang M,Zhang M
17-0041-82 was used in Flow Cytometry to explore the lncRNAs profile in the CD4+T cells from the mouse model of acute asthma.
Fri Apr 08 00:00:00 EDT 2022
Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.
Frontiers in immunology
Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y
17-0041 was used in Flow cytometry/Cell sorting to establish Tpl2 as a critical mediator of MDSC recruitment and highlight the therapeutic potential of Tpl2 for the treatment of fulminant hepatitis (FH).
Wed Oct 14 00:00:00 EDT 2020
Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity.
Nature metabolism
Seo JB,Riopel M,Cabrales P,Huh JY,Bandyopadhyay GK,Andreyev AY,Murphy AN,Beeman SC,Smith GI,Klein S,Lee YS,Olefsky JM
17-0041-82 was used in Flow Cytometry to demonstrate that increased adipocyte O2 demand, mediated by ANT2 activity, is the dominant cause of adipocyte hypoxia.
Tue Jan 01 00:00:00 EST 2019
Frontline Science: Abnormalities in the gut mucosa of non-obese diabetic mice precede the onset of type 1 diabetes.
Journal of leukocyte biology
Miranda MCG,Oliveira RP,Torres L,Aguiar SLF,Pinheiro-Rosa N,Lemos L,Guimarães MA,Reis D,Silveira T,Ferreira Ê,Moreira TG,Cara DC,Maioli TU,Kelsall BL,Carlos D,Faria AMC
17-0041-82 was used in Flow cytometry/Cell sorting to show that disorders in the intestinal mucosa of NOD mice can potentially interfere with the development of T1D due the close relationship between the gut and the pancreas.
Sun Sep 01 00:00:00 EDT 2019
The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis.
Frontiers in pharmacology
Hansel C,Erschfeld S,Baues M,Lammers T,Weiskirchen R,Trautwein C,Kroy DC,Drescher HK
17-0041 was used in Flow cytometry/Cell sorting to investigate the expression profile of inhibitory T cell receptors on CD4 and CD8 T cells in a mouse model of non-alcoholic steatohepatitis.
Wed Sep 30 00:00:00 EDT 2020
The immune mediated role of extracellular HMGB1 in a heterotopic model of bladder cancer radioresistance.
Scientific reports
Ayoub M,Shinde-Jadhav S,Mansure JJ,Alvarez F,Connell T,Seuntjens J,Piccirillo CA,Kassouf W
17-0041 was used in Flow cytometry/Cell sorting to identify extracellular HMGB1 is involved in the promotion of pro-tumor immune mechanisms in bladder cancer radioresistance.
Tue Apr 23 00:00:00 EDT 2019
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
17-0041 was used in Flow cytometry/Cell sorting to study circular RNA-mediated maintenance of hematopoeitic stem cell homeostasis.
Tue Apr 17 00:00:00 EDT 2018
PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity.
Clinical cancer research : an official journal of the American Association for Cancer Research
Buchan SL,Fallatah M,Thirdborough SM,Taraban VY,Rogel A,Thomas LJ,Penfold CA,He LZ,Curran MA,Keler T,Al-Shamkhani A
17-0041 was used in Flow cytometry/Cell sorting to show that suboptimal T-cell invigoration in cancer patients undergoing treatment with PD-1 checkpoint blockers will be improved by dual PD-1 blockade and CD27 agonism.
Tue May 15 00:00:00 EDT 2018
Anti-CD200 attenuates concanavalin A induced hepatitis via modulating the imbalance of CD4+ T lymphocyte differentiation in mice.
American journal of translational research
Zhao X,Ding S,Geng C,Man Z,Pan M,Sun L,Hu B,Wang H
17-0041 was used in Flow cytometry/Cell sorting to research the effect of CD200 on the differentiation of CD4+ T lymphocyte.
Wed Sep 30 00:00:00 EDT 2020
Regulated Release of Cryptococcal Polysaccharide Drives Virulence and Suppresses Immune Cell Infiltration into the Central Nervous System.
Infection and immunity
Denham ST,Verma S,Reynolds RC,Worne CL,Daugherty JM,Lane TE,Brown JCS
17-0041 was used in Flow cytometry/Cell sorting to show that exo-glucuronoxylomannan (exo-GXM) performs a different role from capsule GXM during infection, altering cell size and suppressing inflammation.
Thu Mar 01 00:00:00 EST 2018
Absence of Receptor Guanylyl Cyclase C Enhances Ileal Damage and Reduces Cytokine and Antimicrobial Peptide Production during Oral Salmonella enterica Serovar Typhimurium Infection.
Infection and immunity
Majumdar S,Mishra V,Nandi S,Abdullah M,Barman A,Raghavan A,Nandi D,Visweswariah SS
17-0041 was used in Flow cytometry/Cell sorting to suggest that the receptor guanylyl cyclase C confers a survival advantage during gut-mediated Salmonella enterica serovar Typhimurium pathogenesis.
Tue May 01 00:00:00 EDT 2018
Human umbilical cord-derived mesenchymal stem cells ameliorate the enteropathy of food allergies in mice.
Experimental and therapeutic medicine
Yan N,Xu J,Zhao C,Wu Y,Gao F,Li C,Zhou W,Xiao T,Zhou X,Shao Q,Xia S
17-0041-82 was used in Flow Cytometry to that CSFV (classical swine fever virus) infection reduces pyruvate levels while promotes lactate release in pigs and in PK-15 cells.
Sat Dec 01 00:00:00 EST 2018
STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia.
Cell reports
Saint Fleur-Lominy S,Maus M,Vaeth M,Lange I,Zee I,Suh D,Liu C,Wu X,Tikhonova A,Aifantis I,Feske S
17-0041 was used in Flow cytometry/Cell sorting to investigate the role of store-operated Ca2+ entry mediated by ORAI1, and STIM1 and STIM2 in T-cell acute lymphoblastic leukaemia.
Tue Sep 11 00:00:00 EDT 2018
Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Peng J,Xiao Y,Li W,Yang Q,Tan L,Jia Y,Qu Y,Qian Z
17-0041 was used in Flow cytometry/Cell sorting to demonstrate that NLG919/IR780 micelles combine PTT, immunotherapy, suppress the tumour margin and distal tumour growth post photothermal therapy.
Tue May 01 00:00:00 EDT 2018
Galectin-8 Favors the Presentation of Surface-Tethered Antigens by Stabilizing the B Cell Immune Synapse.
Cell reports
Obino D,Fetler L,Soza A,Malbec O,Saez JJ,Labarca M,Oyanadel C,Del Valle Batalla F,Goles N,Chikina A,Lankar D,Segovia-Miranda F,Garcia C,Léger T,Gonzalez A,Espéli M,Lennon-Duménil AM,Yuseff MI
17-0041 was used in Flow cytometry/Cell sorting to examine the mechanism by which Galectin-8 favours the presentation of surface-tethered antigens.
Tue Dec 11 00:00:00 EST 2018
Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge.
Nature communications
Yi S,Zhai J,Niu R,Zhu G,Wang M,Liu J,Huang H,Wang Y,Jing X,Kang L,Song W,Shi Y,Tang H
17-0041 was used in Flow cytometry/Cell sorting to suggest that different lung antigen-presenting cells modulate lung cDC1-mediated eosinophil recruitment dynamically.
Mon Sep 24 00:00:00 EDT 2018
A protocol for generating induced T cells by reprogramming B cells in vivo.
Cell regeneration (London, England)
Weng Q,Hu F,Zhang M,Dong Y,Lv C,Wang Y,Liu X,Wang J
17-0041-82 was used in Flow cytometry/Cell sorting to describe a protocol for generating functional T cells from Hoxb5-expressing B cells in vivo.
Sat Sep 01 00:00:00 EDT 2018
Interference with KCTD9 inhibits NK cell activation and ameliorates fulminant liver failure in mice.
BMC immunology
Zhang X,Zhu L,Zhou Y,Shi A,Wang H,Han M,Wan X,Kilonzo SB,Luo X,Chen T,Ning Q
17-0041 was used in Flow cytometry/Cell sorting to propose that target inhibition of KCTD9 may prohibit NK cells activity and thus ameliorate liver damage in viral fulminant hepatitis.
Mon Jun 25 00:00:00 EDT 2018
ADAMTS1 protease is required for a balanced immune cell repertoire and tumour inflammatory response.
Scientific reports
Rodríguez-Baena FJ,Redondo-García S,Peris-Torres C,Martino-Echarri E,Fernández-Rodríguez R,Plaza-Calonge MDC,Anderson P,Rodríguez-Manzaneque JC
17-0041-82 was used in Flow Cytometry to confirm a pro-inflammatory landscape in the absence of ADAMTS1, correlating with tumour blockade, supporting its novel role as a modulator of the immune cell response.
Thu Aug 30 00:00:00 EDT 2018
Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation.
Scientific reports
Chen EW,Brzostek J,Gascoigne NRJ,Rybakin V
17-0041 was used in Flow cytometry/Cell sorting to develop a screening strategy for the identification of small molecules affecting T cell receptor (TCR) signalling based on the uncoupling of TCR stimulation from cellular responses in developing thymocytes.
Tue Jul 03 00:00:00 EDT 2018
Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity.
Frontiers in immunology
Araujo Furlan CL,Tosello Boari J,Rodriguez C,Canale FP,Fiocca Vernengo F,Boccardo S,Beccaria CG,Adoue V,Joffre O,Gruppi A,Montes CL,Acosta Rodriguez EV
17-0041 was used in Flow cytometry/Cell sorting to study the role of regulatory T cells during Trypanosoma cruzi infection.
Thu Sep 26 00:00:00 EDT 2019
CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production.
Cell death & disease
Yu L,Yang F,Zhang F,Guo D,Li L,Wang X,Liang T,Wang J,Cai Z,Jin H
17-0041 was used in Flow cytometry/Cell sorting to study the importance of the C-type lectin receptor CD69 to the suppressive function of Tregs.
Wed Sep 05 00:00:00 EDT 2018
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
17-0041 was used in Flow cytometry/Cell sorting to identify a regulatory subpopulation of innate lymphoid cells that exists in the gut, and harbour a unique gene identity.
Thu Sep 21 00:00:00 EDT 2017
Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity.
Cell metabolism
Westerterp M,Gautier EL,Ganda A,Molusky MM,Wang W,Fotakis P,Wang N,Randolph GJ,D'Agati VD,Yvan-Charvet L,Tall AR
17-0041 was used in Flow cytometry/Cell sorting to identify an essential role of DC cholesterol efflux pathways in maintaining immune tolerance.
Tue Jun 06 00:00:00 EDT 2017
Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.
Cancer research
Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B
17-0041-82 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.
Wed Nov 01 00:00:00 EDT 2017
Modulation of Endoplasmic Reticulum Stress Controls CD4+ T-cell Activation and Antitumor Function.
Cancer immunology research
Thaxton JE,Wallace C,Riesenberg B,Zhang Y,Paulos CM,Beeson CC,Liu B,Li Z
17-0041 was used in Flow cytometry/Cell sorting to investigate whether the endoplasmic reticulum stress response may be important for CD4+ T-cell activation and whether gp96 is integral to this process.
Tue Aug 01 00:00:00 EDT 2017
Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency.
Gut microbes
Jacobs JP,Lin L,Goudarzi M,Ruegger P,McGovern DP,Fornace AJ,Borneman J,Xia L,Braun J
17-0041 was used in Flow cytometry/Cell sorting to identify polymorphisms near C1galt1 and its molecular chaperone, Cosmc, were associated with altered composition of the colonic mucosal microbiota.
Mon Jan 02 00:00:00 EST 2017
Primary Heligmosomoides polygyrus bakeri infection induces myeloid-derived suppressor cells that suppress CD4+ Th2 responses and promote chronic infection.
Mucosal immunology
Valanparambil RM,Tam M,Jardim A,Geary TG,Stevenson MM
17-0041 was used in in vitro experiments to study the exact identity and role of the F4/80-CD11b+Gr+ cells accumulating around encysting larvae in intestinal tissue during primary Heligmosomoides polygyrus bakeri infection in mice.
Sun Jan 01 00:00:00 EST 2017
IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection.
PLoS pathogens
Valanparambil RM,Tam M,Gros PP,Auger JP,Segura M,Gros P,Jardim A,Geary TG,Ozato K,Stevenson MM
17-0041 was used in Flow cytometry/Cell sorting to study the role of interferon regulatory factor-8 on Th2 immunity to Helimosomoides polygyrus bakeri infection.
Sun Oct 01 00:00:00 EDT 2017
Adenoviral production of interleukin-2 at the tumor site removes the need for systemic postconditioning in adoptive cell therapy.
International journal of cancer
Santos JM,Havunen R,Siurala M,Cervera-Carrascon V,Tähtinen S,Sorsa S,Anttila M,Karell P,Kanerva A,Hemminki A
17-0041-82 was used in Flow Cytometry to study the efficacy and safety of intratumorally administered IL-2 coding adenoviruses in combination with lymphocyte therapy in Syrian hamsters bearing pancreatic tumours.
Sun Oct 01 00:00:00 EDT 2017
Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells.
Nature communications
Downs-Canner S,Berkey S,Delgoffe GM,Edwards RP,Curiel T,Odunsi K,Bartlett DL,Obermajer N
17-0041 was used in Flow cytometry/Cell sorting to demonstrate the tumour-associated conversion of Th17 cells to Treg cells and identify transdifferentiation-associated markers.
Tue Mar 14 00:00:00 EDT 2017
Herpes simplex virus-1 infects the olfactory bulb shortly following ocular infection and exhibits a long-term inflammatory profile in the form of effector and HSV-1-specific T cells.
Journal of neuroinflammation
Menendez CM,Carr DJJ
17-0041 was used in Flow cytometry/Cell sorting to characterise the capacity of Herpes simplex virus 1 to establish latency within olfactory bulb tissue and profile the local T lymphocyte response.
Fri Jun 23 00:00:00 EDT 2017
The Phytochemical Bergenin Enhances T Helper 1 Responses and Anti-Mycobacterial Immunity by Activating the MAP Kinase Pathway in Macrophages.
Frontiers in cellular and infection microbiology
Dwivedi VP,Bhattacharya D,Yadav V,Singh DK,Kumar S,Singh M,Ojha D,Ranganathan A,Van Kaer L,Chattopadhyay D,Das G
17-0041 was used in Flow cytometry/Cell sorting to study the role of bergenin in the activation of MAP kinase and ERK pathways in macrophages for host protection against TB.
Wed Dec 27 00:00:00 EST 2017
Naïve helper T cells with high CD5 expression have increased calcium signaling.
PloS one
Freitas CMT,Hamblin GJ,Raymond CM,Weber KS
17-0041 was used in Flow cytometry/Cell sorting to examine the role of CD5 expression and calcium signaling in the primary response of T cells, using two Listeria monocytogenes specific T helper cells (LLO118 and LLO56).
Tue Sep 26 00:00:00 EDT 2017
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop.
Nature communications
Béguelin W,Rivas MA,Calvo Fernández MT,Teater M,Purwada A,Redmond D,Shen H,Challman MF,Elemento O,Singh A,Melnick AM
17-0041 was used in Flow cytometry/Cell sorting to show EZH2 mediates germinal centre formation through epigenetic silencing of CDKN1A and release of cell cycle checkpoints.
Thu Oct 12 00:00:00 EDT 2017
Immunomodulatory Effects of Adipose Tissue-Derived Stem Cells on Concanavalin A-Induced Acute Liver Injury in Mice.
Cell medicine
Yoshizumi Y,Yukawa H,Iwaki R,Fujinaka S,Kanou A,Kanou Y,Yamada T,Nakagawa S,Ohara T,Nakagiri K,Ogihara Y,Tsutsui Y,Hayashi Y,Ishigami M,Baba Y,Ishikawa T
17-0041 was used in Flow cytometry/Cell sorting to evaluate the therapeutic effects of adipose tissue-derived stem cells on fulminant hepatic failure.
Sun Jan 08 00:00:00 EST 2017
Low energy X-ray (grenz ray) treatment of purified islets prior to allotransplant markedly decreases passenger leukocyte populations.
Islets
Pawlick R,Gala-Lopez B,Pepper AR,Abualhassan N,Bruni A,Suzuki K,Rayat G,Elliott JF,Shapiro AMJ
17-0041-82 was used in Flow cytometry/Cell sorting to suggest that brief treatment of isolated islets with low energy grenz rays before allotransplantation can significantly reduce passenger leukocytes and promote graft survival, possibly by inducing donor dendritic cells to differentiate toward a tolerogenic phenotype.
Tue Jul 04 00:00:00 EDT 2017
IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis.
Scientific reports
Peshkova IO,Fatkhullina AR,Mikulski Z,Ley K,Koltsova EK
17-0041 was used in Flow cytometry/Cell sorting to study the role of IL-27R in controlling myeloid cell accumulation and activation in atherosclerosis.
Tue May 23 00:00:00 EDT 2017
γδT cells but not αβT cells contribute to sepsis-induced white matter injury and motor abnormalities in mice.
Journal of neuroinflammation
Zhang X,Rocha-Ferreira E,Li T,Vontell R,Jabin D,Hua S,Zhou K,Nazmi A,Albertsson AM,Sobotka K,Ek J,Thornton C,Hagberg H,Mallard C,Leavenworth JW,Zhu C,Wang X
17-0041 was used in Flow cytometry/Cell sorting to study the contribution of different T cell subsets to white matter injury and consequent behavioural changes.
Wed Dec 20 00:00:00 EST 2017
The Effects of Tacrolimus on T-Cell Proliferation Are Short-Lived: A Pilot Analysis of Immune Function Testing.
Transplantation direct
Laskin BL,Jiao J,Baluarte HJ,Amaral S,Furth SL,Akimova T,Hancock WW,Levine MH,Reese PP,Beier UH
17-0041 was used in Flow cytometry/Cell sorting to develop an immune function assay to measure T-cell proliferation after exposure to immunosuppression in vivo.
Tue Aug 01 00:00:00 EDT 2017
Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease.
Scientific reports
Ogawa Y,He H,Mukai S,Imada T,Nakamura S,Su CW,Mahabole M,Tseng SC,Tsubota K
17-0041 was used in Immunohistochemistry to help prove the concept that subcutaneous and subconjunctival injection of HC-HA/PTX3 is a novel approach to prevent dry eye disease caused by cGVHD.
Mon Feb 06 00:00:00 EST 2017
Cooperation of Oncolytic Herpes Virotherapy and PD-1 Blockade in Murine Rhabdomyosarcoma Models.
Scientific reports
Chen CY,Wang PY,Hutzen B,Sprague L,Swain HM,Love JK,Stanek JR,Boon L,Conner J,Cripe TP
17-0041 was used in Flow cytometry/Cell sorting to show the combination of PD-1 blockade and oHSV-1 may be an effective treatment strategy for childhood soft tissue sarcoma.
Wed May 24 00:00:00 EDT 2017
Distinctive Expression of Bcl-2 Factors in Regulatory T Cells Determines a Pharmacological Target to Induce Immunological Tolerance.
Frontiers in immunology
Gabriel SS,Bon N,Chen J,Wekerle T,Bushell A,Fehr T,Cippà PE
17-0041 was used in Flow cytometry/Cell sorting to show that blocking the intrinsic apoptosis pathway with a Bcl-2/Bcl-xL inhibitor (ABT-737) caused a selective depletion of effector T cells and a relative enrichment of Tregs in vivo.
Mon Mar 14 00:00:00 EDT 2016
Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Song Y,Kumar V,Wei HX,Qiu J,Stanley P
17-0041 was used in Magnetic cell separation to investigate the roles for maniac fringe (MFNG) and radical fringe (RFNG) in T cell development, RFNG in B cell development, and Fringes in T and B cell activation, showing that they promote T and B cell development.
Fri Jan 01 00:00:00 EST 2016
Low dose of GRP78-targeting subtilase cytotoxin improves the efficacy of photodynamic therapy in vivo.
Oncology reports
Gabrysiak M,Wachowska M,Barankiewicz J,Pilch Z,Ratajska A,Skrzypek E,Winiarska M,Domagala A,Rygiel TP,Jozkowicz A,Boon L,Golab J,Firczuk M
17-0041 was used in Flow cytometry/Cell sorting to identify factors allowing for the most immunogenic response to photodynamic therapy.
Wed Jun 01 00:00:00 EDT 2016
Low-Dose Intestinal Trichuris muris Infection Alters the Lung Immune Microenvironment and Can Suppress Allergic Airway Inflammation.
Infection and immunity
Chenery AL,Antignano F,Burrows K,Scheer S,Perona-Wright G,Zaph C
17-0041 was used in Flow cytometry/Cell sorting to study crosstalk between the intestine and lung during disease, showing that low-dose intestinal Trichuris muris infection alters the lung immune microenvironment.
Mon Feb 01 00:00:00 EST 2016
CD38 gene-modified dendritic cells inhibit murine asthma development by increasing IL-12 production and promoting Th1 cell differentiation.
Molecular medicine reports
Wang J,Zhu W,Chen Y,Lin Z,Ma S
17-0041 was used in Flow cytometry/Cell sorting to assess whether CD38 expression affects dendritic cell function in asthma development.
Tue Nov 01 00:00:00 EDT 2016
CD4+ T cell responses in Balb/c mice with food allergy induced by trinitrobenzene sulfonic acid and ovalbumin.
Molecular medicine reports
Sun CY,Bai J,Hu TY,Cheng BH,Ma L,Fan XQ,Yang PC,Zheng PY,Liu ZQ
17-0041-82 was used in Flow Cytometry to suggest that TNBS, as a hapten, combined with food antigens may lead to a Th2 cell response in the intestinal mucosa.
Wed Jun 01 00:00:00 EDT 2016
Cell Type Preference of a Novel Human Derived Cell-Permeable Peptide dNP2 and TAT in Murine Splenic Immune Cells.
PloS one
Lim S,Lee JA,Koo JH,Kang TG,Ha SJ,Choi JM
17-0041 was used in Flow cytometry/Cell sorting to demonstrate that uptake of cell-permeable peptides differs between phagocytic and non-phagocytic immune cells.
Tue Jul 11 00:00:00 EDT 2017
Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.
Nature communications
Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B
17-0041 was used in Flow cytometry/Cell sorting to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.
Mon Nov 21 00:00:00 EST 2016
Streptomycin treatment alters the intestinal microbiome, pulmonary T cell profile and airway hyperresponsiveness in a cystic fibrosis mouse model.
Scientific reports
Bazett M,Bergeron ME,Haston CK
17-0041 was used in Flow cytometry/Cell sorting to reveal a potential intestinal microbiome influence on lung response in BALB/c Cftr(tm1UNC) mice.
Tue Jan 12 00:00:00 EST 2016
Enhanced Anti-Tumor Efficacy through a Combination of Integrin αvβ6-Targeted Photodynamic Therapy and Immune Checkpoint Inhibition.
Theranostics
Gao L,Zhang C,Gao D,Liu H,Yu X,Lai J,Wang F,Lin J,Liu Z
17-0041 was used in Flow cytometry/Cell sorting to investigate whether integrin αvβ6-targeted photodynamic therapy (PDT) of tumors using a DSAB-HK could trigger the host immune response, showing that DSAB-HK led to inhibited growth of 4T1 tumours and promoted maturation of dendritic cells.
Tue Dec 13 00:00:00 EST 2016
Enlarged colitogenic T cell population paradoxically supports colitis prevention through the B-lymphocyte-dependent peripheral generation of CD4(+)Foxp3(+) Treg cells.
Scientific reports
do Canto FB,Campos SM,Granato A,da Silva RF,de Paiva LS,Nóbrega A,Bellio M,Fucs R
17-0041 was used in Flow cytometry/Cell sorting to show that augmentation of naïve T cell numbers in the inoculum of RAG KO mice suppresses colon disease and promotes immune homeostasis.
Wed Jun 29 00:00:00 EDT 2016
Gastric LTi cells promote lymphoid follicle formation but are limited by IRAK-M and do not alter microbial growth.
Mucosal immunology
Shiu J,Piazuelo MB,Ding H,Czinn SJ,Drakes ML,Banerjee A,Basappa N,Kobayashi KS,Fricke WF,Blanchard TG
17-0041 was used in Flow cytometry/Cell sorting to investigate the role of lymphoid tissue inducer cells in the gastric mucosa in the context of microbial infection.
Tue Sep 01 00:00:00 EDT 2015
The immunosuppressive enzyme IL4I1 promotes FoxP3(+) regulatory T lymphocyte differentiation.
European journal of immunology
Cousin C,Aubatin A,Le Gouvello S,Apetoh L,Castellano F,Molinier-Frenkel V
17-0041 was used in Flow cytometry/Cell sorting to study the effect of IL4I1 on naive CD4+ T cell differentiation.
Mon Jun 01 00:00:00 EDT 2015
Intratumoral INF-γ triggers an antiviral state in GL261 tumor cells: a major hurdle to overcome for oncolytic vaccinia virus therapy of cancer.
Molecular therapy oncolytics
Kober C,Weibel S,Rohn S,Kirscher L,Szalay AA
17-0041 was used in Flow cytometry/Cell sorting to identify microenvironmental factors, which may be decisive for failure or success of oncolytic VACV therapy.
Wed Apr 27 00:00:00 EDT 2016
MHC-mismatched mixed chimerism mediates thymic deletion of cross-reactive autoreactive T cells and prevents insulitis in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950)
Racine JJ,Zhang M,Wang M,Morales W,Shen C,Zeng D
17-0041 was used in Flow cytometry/Cell sorting to investigate whether mismatched MHC class II in mixed chimeras mediates deletion of cross-reactive autoreactive thymocytes.
Thu Jan 01 00:00:00 EST 2015
Monitoring and cell-specific deletion of C5aR1 using a novel floxed GFP-C5aR1 reporter knock-in mouse.
Journal of immunology (Baltimore, Md. : 1950)
Karsten CM,Laumonnier Y,Eurich B,Ender F,Bröker K,Roy S,Czabanska A,Vollbrandt T,Figge J,Köhl J
17-0041 was used in in vitro experiments to study cell-specific deletion of C5aR1 using a GFP-reporter knock-in mouse model.
Sun Feb 15 00:00:00 EST 2015
MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR.
Journal of immunology (Baltimore, Md. : 1950)
Singh Y,Garden OA,Lang F,Cobb BS
17-0041 was used in Flow cytometry/Cell sorting to understand miRNA function in Treg development..
Tue Dec 15 00:00:00 EST 2015
Programmed cell death receptor ligand 1 modulates the regulatory T cells' capacity to repress shock/sepsis-induced indirect acute lung injury by recruiting phosphatase SRC homology region 2 domain-containing phosphatase 1.
Shock (Augusta, Ga.)
Tang L,Bai J,Chung CS,Lomas-Neira J,Chen Y,Huang X,Ayala A
17-0041 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which the programmed cell death receptor 1 ligand suppresses lung injury.
Thu Jan 01 00:00:00 EST 2015
Immunostimulatory Effects Triggered by Enterococcus faecalis CECT7121 Probiotic Strain Involve Activation of Dendritic Cells and Interferon-Gamma Production.
PloS one
Molina MA,Díaz AM,Hesse C,Ginter W,Gentilini MV,Nuñez GG,Canellada AM,Sparwasser T,Berod L,Castro MS,Manghi MA
17-0041 was used in Flow cytometry/Cell sorting to elucidate the influence of E. faecalis CECT7121 on dendritic cells and the outcome of the immune responses.
Tue Apr 19 00:00:00 EDT 2016
Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization.
Nature communications
Lu G,Zhang R,Geng S,Peng L,Jayaraman P,Chen C,Xu F,Yang J,Li Q,Zheng H,Shen K,Wang J,Liu X,Wang W,Zheng Z,Qi CF,Si C,He JC,Liu K,Lira SA,Sikora AG,Li L,Xiong H
17-0041 was used in Flow cytometry/Cell sorting to show that iNOS-deficient mice display enhanced classically activated M1 macrophage polarization without major effects on alternatively activated M2 macrophages.
Fri Mar 27 00:00:00 EDT 2015
Inhibition of iNOS activity enhances the anti-tumor effects of alpha-galactosylceramide in established murine cancer model.
Oncotarget
Ito H,Ando T,Seishima M
17-0041 was used in Flow cytometry/Cell sorting to investigate how the inhibition of iNOS expression could enhance the therapeutic efficacy of GalCer via the increase of tumor antigen-specific immune response and the suppression of MDSCs.
Tue Dec 08 00:00:00 EST 2015
IKK2 inhibition using TPCA-1-loaded PLGA microparticles attenuates laser-induced choroidal neovascularization and macrophage recruitment.
PloS one
Gaddipati S,Lu Q,Kasetti RB,Miller MC,Lu Q,Trent JO,Kaplan HJ,Li Q
17-0041 was used in Flow cytometry/Cell sorting to suggest a potential clinical application of TPCA-1 delivered by microparticles in treatment of CNV in the patients with age-related macular degeneration and other retinal neovascularization diseases.
Thu Apr 07 00:00:00 EDT 2016
Standard sub-thermoneutral caging temperature influences radiosensitivity of hematopoietic stem and progenitor cells.
PloS one
Povinelli BJ,Kokolus KM,Eng JW,Dougher CW,Curtin L,Capitano ML,Sailsbury-Ruf CT,Repasky EA,Nemeth MJ
17-0041 was used in Flow cytometry/Cell sorting to demonstrate that chronic stress of laboratory mice increases the resistance of hematopoietic stem and progenitor cells to irradiation-induced apoptosis.
Tue Feb 09 00:00:00 EST 2016
T cell responses are elicited against Respiratory Syncytial Virus in the absence of signalling through TLRs, RLRs and IL-1R/IL-18R.
Scientific reports
Goritzka M,Pereira C,Makris S,Durant LR,Johansson C
17-0041 was used in Flow cytometry/Cell sorting to highlight an unappreciated level of redundancy in pathways that couple innate virus sensing to adaptive immunity.
Mon Dec 21 00:00:00 EST 2015
Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic mice.
Science translational medicine
Faith JJ,Ahern PP,Ridaura VK,Cheng J,Gordon JI
17-0041 was used in Flow cytometry/Cell sorting to describe a method in which a clonally arrayed collection of cultured, sequenced bacteria was generated from one of several human fecal microbiota samples found to transmit a particular phenotype to recipient germ-free mice.
Wed Jan 22 00:00:00 EST 2014
The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells.
The EMBO journal
Jurkin J,Henkel T,Nielsen AF,Minnich M,Popow J,Kaufmann T,Heindl K,Hoffmann T,Busslinger M,Martinez J
17-0041 was used in Flow cytometry/Cell sorting to investigate the mammalian ligase required for cleavage of XBP1, showing that tRNA ligase complex mediates splicing of XBP1 mRNA.
Wed Dec 17 00:00:00 EST 2014
Elimination of IL-10-inducing T-helper epitopes from an IGFBP-2 vaccine ensures potent antitumor activity.
Cancer research
Cecil DL,Holt GE,Park KH,Gad E,Rastetter L,Childs J,Higgins D,Disis ML
17-0041 was used in Flow cytometry/Cell sorting to investigate the deletion of immunosuppressive epitopes from an IGFBP-2 cancer vaccine as a novel strategy to increase antitumor activity.
Thu May 15 00:00:00 EDT 2014
CX3CR1⁺ cells facilitate the activation of CD4 T cells in the colonic lamina propria during antigen-driven colitis.
Mucosal immunology
Rossini V,Zhurina D,Radulovic K,Manta C,Walther P,Riedel CU,Niess JH
17-0041 was used in Flow cytometry/Cell sorting to study immune cell communication during the development of transfer colitis.
Thu May 01 00:00:00 EDT 2014
Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells.
Molecular metabolism
Singer K,DelProposto J,Morris DL,Zamarron B,Mergian T,Maley N,Cho KW,Geletka L,Subbaiah P,Muir L,Martinez-Santibanez G,Lumeng CN
17-0041 was used in Flow cytometry/Cell sorting to demonstrate how metabolic signals potentiate leukocyte production and dietary priming of haematopoietic progenitors contributes to adipose tissue inflammation.
Mon Sep 01 00:00:00 EDT 2014
Mast cells expedite control of pulmonary murine cytomegalovirus infection by enhancing the recruitment of protective CD8 T cells to the lungs.
PLoS pathogens
Ebert S,Becker M,Lemmermann NA,Büttner JK,Michel A,Taube C,Podlech J,Böhm V,Freitag K,Thomas D,Holtappels R,Reddehase MJ,Stassen M
17-0041 was used in Flow cytometry/Cell sorting to explore the role of mast cells in the recruitment of protective CD8 T cells to the lungs during systemic infection.
Tue Apr 01 00:00:00 EDT 2014
T/B-cell interactions are more transient in response to weak stimuli in SLE-prone mice.
European journal of immunology
Sinai P,Dozmorov IM,Song R,Schwartzberg PL,Wakeland EK,Wülfing C
17-0041 was used in in vitro experiments to analyse primary T and B cells from a mouse model of systemic lupus erythematosus prior to the onset of disease.
Mon Dec 01 00:00:00 EST 2014
In vivo cellular tropism of gorilla simian foamy virus in blood of infected humans.
Journal of virology
Rua R,Betsem E,Montange T,Buseyne F,Gessain A
17-0041 was used in Flow cytometry/Cell sorting to show that CD8+, CD4+, and B lymphocytes are major cellular targets of SFV in the blood of infected humans.
Sat Nov 01 00:00:00 EDT 2014
Roles of major histocompatibility complex class II in inducing protective immune responses to influenza vaccination.
Journal of virology
O E,Lee YT,Ko EJ,Kim KH,Lee YN,Song JM,Kwon YM,Kim MC,Perez DR,Kang SM
17-0041 was used in Flow cytometry/Cell sorting to study the roles of major histocompatibility complex class II in inducing protective immune responses to influenza vaccination.
Tue Jul 01 00:00:00 EDT 2014
Yeast virus-derived stimulator of the innate immune system augments the efficacy of virus vector-based immunotherapy.
Journal of virology
Claudepierre MC,Hortelano J,Schaedler E,Kleinpeter P,Geist M,Remy-Ziller C,Brandely R,Tosch C,Laruelle L,Jawhari A,Menguy T,Marchand JB,Romby P,Schultz P,Hartmann G,Rooke R,Bonnefoy JY,Preville X,Rittner K
17-0041 was used in Flow cytometry/Cell sorting to show that the choice of an appropriate immune modulator can enhance vaccine function.
Thu May 01 00:00:00 EDT 2014
Active players in resolution of shock/sepsis induced indirect lung injury: immunomodulatory effects of Tregs and PD-1.
Journal of leukocyte biology
Tang L,Bai J,Chung CS,Lomas-Neira J,Chen Y,Huang X,Ayala A
17-0041 was used in Flow cytometry/Cell sorting to explore the ability of Tregs to modify the innate immune response induced by experimental iALI.
Sat Nov 01 00:00:00 EDT 2014
Dendritic cell-MHC class II and Itk regulate functional development of regulatory innate memory CD4+ T cells in bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950)
Huang W,Qi Q,Hu J,Huang F,Laufer TM,August A
17-0041 was used in Flow cytometry/Cell sorting to demonstrate that dendritic cells-MHCII and IL-2-inducible T cell kinase regulate the functional development of IMP CD4(+) T cells.
Tue Apr 01 00:00:00 EDT 2014
Cytokine-regulated neutrophil recruitment is required for brain but not spinal cord inflammation during experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Simmons SB,Liggitt D,Goverman JM
17-0041 was used in Flow cytometry/Cell sorting to investigate the pathways that determine whether damage occurs in the brain or spinal cord in multiple sclerosis, showing that cytokine-regulated neutrophil recruitment is required for brain but not spinal cord.
Tue Jul 15 00:00:00 EDT 2014
Oral combined therapy with probiotics and alloantigen induces B cell-dependent long-lasting specific tolerance.
Journal of immunology (Baltimore, Md. : 1950)
Mercadante AC,Perobelli SM,Alves AP,Gonçalves-Silva T,Mello W,Gomes-Santos AC,Miyoshi A,Azevedo V,Faria AM,Bonomo A
17-0041 was used in Flow cytometry/Cell sorting to suggest that combined therapy is a promising strategy for prevention of GVHD with preservation of graft-versus-leukemia in allogenic HSCT.
Sat Feb 15 00:00:00 EST 2014
IκBε is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner.
Journal of immunology (Baltimore, Md. : 1950)
Alves BN,Tsui R,Almaden J,Shokhirev MN,Davis-Turak J,Fujimoto J,Birnbaum H,Ponomarenko J,Hoffmann A
17-0041 was used in Flow cytometry/Cell sorting to illustrate the importance of kinetic considerations in understanding the functional specificity of negative-feedback regulators.
Tue Apr 01 00:00:00 EDT 2014
Salidroside attenuates concanavalin A-induced hepatitis via modulating cytokines secretion and lymphocyte migration in mice.
Mediators of inflammation
Hu B,Zou Y,Liu S,Wang J,Zhu J,Li J,Bo L,Deng X
17-0041 was used in Flow cytometry/Cell sorting to study the modulation of cytokine secretion and lymphocyte migration in mice by the attenuation of concanavalin A-induced hepatitis by Salidroside.
Thu Dec 18 00:00:00 EST 2014
Autophagy is a critical regulator of memory CD8(+) T cell formation.
eLife
Puleston DJ,Zhang H,Powell TJ,Lipina E,Sims S,Panse I,Watson AS,Cerundolo V,Townsend AR,Klenerman P,Simon AK
17-0041 was used in Flow cytometry/Cell sorting to show that mice lacking the autophagy gene Atg7 in T cells failed to establish CD8(+) T cell memory to influenza and MCMV infection.
Tue Nov 11 00:00:00 EST 2014
Homo-oligomerization of the activating natural killer cell receptor NKp30 ectodomain increases its binding affinity for cellular ligands.
The Journal of biological chemistry
Herrmann J,Berberich H,Hartmann J,Beyer S,Davies K,Koch J
17-0041 was used in Flow cytometry/Cell sorting to investigate the molecular details of ligand recognition by NKp30.
Fri Jan 10 00:00:00 EST 2014
Simultaneous inhibition of T helper 2 and T regulatory cell differentiation by small molecules enhances Bacillus Calmette-Guerin vaccine efficacy against tuberculosis.
The Journal of biological chemistry
Bhattacharya D,Dwivedi VP,Kumar S,Reddy MC,Van Kaer L,Moodley P,Das G
17-0041 was used in Flow cytometry/Cell sorting to study the inhibition of Th2 cells and Tregs and the subsequent enhancement of the BCG vaccine efficacy.
Fri Nov 28 00:00:00 EST 2014
A systematic comparison of the anti-tumoural activity and toxicity of the three Adv-TKs.
PloS one
Gao Q,Chen C,Ji T,Wu P,Han Z,Fang H,Li F,Liu Y,Hu W,Gong D,Zhang Z,Wang S,Zhou J,Ma D
17-0041 was used in Flow cytometry/Cell sorting to evaluate the efficacy and safety of adenovirus 5 vectors.
Thu Jan 15 00:00:00 EST 2015
The use of anchored agonists of phagocytic receptors for cancer immunotherapy: B16-F10 murine melanoma model.
PloS one
Janotová T,Jalovecká M,Auerová M,Švecová I,Bruzlová P,Maierová V,Kumžáková Z,Cunátová Š,Vlčková Z,Caisová V,Rozsypalová P,Lukáčová K,Vácová N,Wachtlová M,Salát J,Lieskovská J,Kopecký J,Ženka J
17-0041 was used in Flow cytometry/Cell sorting to assess the anti-tumour potential of fusing phagocytic receptor agonists to cancer cells.
Thu Sep 18 00:00:00 EDT 2014
SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis.
PloS one
Lo Sasso G,Menzies KJ,Mottis A,Piersigilli A,Perino A,Yamamoto H,Schoonjans K,Auwerx J
17-0041 was used in Flow cytometry/Cell sorting to investigate SIRT2 protection against development of inflammatory processes.
Tue Nov 24 00:00:00 EST 2015
Small molecule-directed immunotherapy against recurrent infection by Mycobacterium tuberculosis.
The Journal of biological chemistry
Bhattacharya D,Dwivedi VP,Maiga M,Maiga M,Van Kaer L,Bishai WR,Das G
17-0041 was used in Flow cytometry/Cell sorting to investigate small molecule-directed immunotherapy against Th2 and regulatory T cell subsets to reduce recurrent Mycobacterium tuberculosis infection and drug resistance.
Fri Jun 06 00:00:00 EDT 2014
Isoniazid induces apoptosis of activated CD4+ T cells: implications for post-therapy tuberculosis reactivation and reinfection.
The Journal of biological chemistry
Tousif S,Singh DK,Ahmad S,Moodley P,Bhattacharyya M,Van Kaer L,Das G
17-0041 was used in Flow cytometry/Cell sorting to show that Isoniazid treatment of Mycobacterium tuberculosis treatment is associated with immune impairment.
Fri Oct 31 00:00:00 EDT 2014
Hemozoin induces hepatic inflammation in mice and is differentially associated with liver pathology depending on the Plasmodium strain.
PloS one
Deroost K,Lays N,Pham TT,Baci D,Van den Eynde K,Komuta M,Prato M,Roskams T,Schwarzer E,Opdenakker G,Van den Steen PE
17-0041 was used in Flow cytometry/Cell sorting to elucidate the contribution of hemozoin to hepatic injury in mouse malaria models.
Tue Jan 26 00:00:00 EST 2016
CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.
The Journal of clinical investigation
Lionakis MS,Swamydas M,Fischer BG,Plantinga TS,Johnson MD,Jaeger M,Green NM,Masedunskas A,Weigert R,Mikelis C,Wan W,Lee CC,Lim JK,Rivollier A,Yang JC,Laird GM,Wheeler RT,Alexander BD,Perfect JR,Gao JL,Kullberg BJ,Netea MG,Murphy PM
17-0041 was used in Flow cytometry/Cell sorting to elucidate the roles of innate immune cells in the pathogenesis of C. albicans.
Sun Dec 01 00:00:00 EST 2013
Mesenchymal stem cells are mobilized from the bone marrow during inflammation.
Frontiers in immunology
Koning JJ,Kooij G,de Vries HE,Nolte MA,Mebius RE
17-0041 was used in Flow cytometry/Cell sorting to analyse mesenchymal stem- and T-cell migration during experimental allergic encephalomyelitis.
Wed Mar 06 00:00:00 EST 2013
IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
PLoS pathogens
Schmitz I,Schneider C,Fröhlich A,Frebel H,Christ D,Leonard WJ,Sparwasser T,Oxenius A,Freigang S,Kopf M
17-0041 was used in Flow cytometry/Cell sorting to investigate the role of Foxp3+ regulatory T (Treg) cells during viral infections, showing that IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
Mon Dec 09 00:00:00 EST 2013
Ikaros promotes rearrangement of TCR α genes in an Ikaros null thymoma cell line.
European journal of immunology
Collins B,Clambey ET,Scott-Browne J,White J,Marrack P,Hagman J,Kappler JW
17-0041 was used in Flow cytometry/Cell sorting to study the functions of Ikaros in immune cells in transition from pre-T cells to CD4(+) CD8(+) thymocytes.
Fri Feb 01 00:00:00 EST 2013
Intensity of the humoral response to cytomegalovirus is associated with the phenotypic and functional status of the immune system.
Journal of virology
Alonso Arias R,Moro-García MA,Echeverría A,Solano-Jaurrieta JJ,Suárez-García FM,López-Larrea C
17-0041 was used in Flow cytometry/Cell sorting to study the association of the phenotypic and functional status of the immune system with the intensity of the humoral response to Cytomegalovirus.
Mon Apr 01 00:00:00 EDT 2013
Parental dietary fat intake alters offspring microbiome and immunity.
Journal of immunology (Baltimore, Md. : 1950)
Myles IA,Fontecilla NM,Janelsins BM,Vithayathil PJ,Segre JA,Datta SK
17-0041 was used in Flow cytometry/Cell sorting to reveal that parental fat consumption can leave a "lard legacy", impacting offspring immunity and health.
Sun Sep 15 00:00:00 EDT 2013
Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development.
Journal of immunology (Baltimore, Md. : 1950)
Li J,Zhao Z,Carter C,Ehrlich LI,Bedford MT,Richie ER
17-0041 was used in Flow cytometry/Cell sorting to demonstrate how CARM1 is a key epigenetic regulator of hematopoiesis that affects multiple lineages at various stages of differentiation.
Tue Jan 15 00:00:00 EST 2013
The novel role of IL-7 ligation to IL-7 receptor in myeloid cells of rheumatoid arthritis and collagen-induced arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Chen Z,Kim SJ,Chamberlain ND,Pickens SR,Volin MV,Volkov S,Arami S,Christman JW,Prabhakar BS,Swedler W,Mehta A,Sweiss N,Shahrara S
17-0041 was used in Flow cytometry/Cell sorting to study the role of IL7/IL7R in myeloid cells of rheumatoid arthritis and collagen induced arthritis.
Wed May 15 00:00:00 EDT 2013
Interaction of CD99 with its paralog CD99L2 positively regulates CD99L2 trafficking to cell surfaces.
Journal of immunology (Baltimore, Md. : 1950)
Nam G,Lee YK,Lee HY,Ma MJ,Araki M,Araki K,Lee S,Lee IS,Choi EY
17-0041 was used in Flow cytometry/Cell sorting to explore the interaction between mouse CD99 and its paralog CD99-like 2, and the consequences of this interaction.
Sun Dec 01 00:00:00 EST 2013
Ganciclovir prophylaxis improves late murine cytomegalovirus-induced renal allograft damage.
Transplantation
Shimamura M,Seleme MC,Guo L,Saunders U,Schoeb TR,George JF,Britt WJ
17-0041 was used in Flow cytometry/Cell sorting to examine the lasting effect of Ganciclovir treatment on renal allografts after the discontinuation of prophylaxis.
Tue Jan 15 00:00:00 EST 2013
Ontogeny and localization of the cells produce IL-2 in healthy animals.
Cytokine
Yamamoto M,Seki Y,Iwai K,Ko I,Martin A,Tsuji N,Miyagawa S,Love RB,Iwashima M
17-0041 was used in Flow cytometry/Cell sorting to study how a group of Tr1 cells may have additional roles in immune homeostasis through IL-2 production to aid in the maintenance of other regulatory T cells..
Fri Mar 01 00:00:00 EST 2013
Resistance to malaria by enhanced phagocytosis of erythrocytes in LMP7-deficient mice.
PloS one
Duan X,Imai T,Chou B,Tu L,Himeno K,Suzue K,Hirai M,Taniguchi T,Okada H,Shimokawa C,Hisaeda H
17-0041 was used in Flow cytometry/Cell sorting to study how RBCs of LMP7-deficient mice were more likely to deform in response to infection with malaria parasites.
Tue Sep 17 00:00:00 EDT 2013
Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.
Blood
Li Z,Huang H,Li Y,Jiang X,Chen P,Arnovitz S,Radmacher MD,Maharry K,Elkahloun A,Yang X,He C,He M,Zhang Z,Dohner K,Neilly MB,Price C,Lussier YA,Zhang Y,Larson RA,Le Beau MM,Caligiuri MA,Bullinger L,Valk PJ,Delwel R,Lowenberg B,Liu PP,Marcucci G,Bloomfield CD,Rowley JD,Chen J
17-0041 was used in Flow cytometry/Cell sorting to study the prognostic impact of the four members of the miR-181 family in patients with CA-AML.
Thu Mar 08 00:00:00 EST 2012
Interleukin-27 receptor limits atherosclerosis in Ldlr-/- mice.
Circulation research
Koltsova EK,Kim G,Lloyd KM,Saris CJ,von Vietinghoff S,Kronenberg M,Ley K
17-0041 was used in Flow cytometry/Cell sorting to establish a novel role for IL-27 receptor signalling in limiting arterial inflammation and atherosclerosis.
Fri Oct 26 00:00:00 EDT 2012
Divergent requirement for Gαs and cAMP in the differentiation and inflammatory profile of distinct mouse Th subsets.
The Journal of clinical investigation
Li X,Murray F,Koide N,Goldstone J,Dann SM,Chen J,Bertin S,Fu G,Weinstein LS,Chen M,Corr M,Eckmann L,Insel PA,Raz E
17-0041 was used in Flow cytometry/Cell sorting to demonstrate that altering cAMP levels in CD4(+) T cells could provide an immunomodulatory approach targeting specific Th subsets.
Thu Mar 01 00:00:00 EST 2012
Plasmacytoid dendritic cells play a key role in promoting atherosclerosis in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology
Macritchie N,Grassia G,Sabir SR,Maddaluno M,Welsh P,Sattar N,Ialenti A,Kurowska-Stolarska M,McInnes IB,Brewer JM,Garside P,Maffia P
17-0041 was used in Flow cytometry/Cell sorting to identify a potential role for pDC targeting in the control of the pathology of coronary artery disease.
Thu Nov 01 00:00:00 EDT 2012
Diabetogenic T-cell clones recognize an altered peptide of chromogranin A.
Diabetes
Delong T,Baker RL,He J,Barbour G,Bradley B,Haskins K
17-0041 was used in Flow cytometry/Cell sorting to investigate the role of WE14 in diabetes.
Sat Dec 01 00:00:00 EST 2012
T cells interact with T cells via CD40-CD154 to promote autoimmunity in type 1 diabetes.
European journal of immunology
Baker RL,Mallevaey T,Gapin L,Haskins K
17-0041 was used in Flow cytometry/Cell sorting to investigate how CD40 may be an important signalling molecule on autoreactive CD4+ T cells and contribute to their pathogenic effector function.
Thu Mar 01 00:00:00 EST 2012
CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential.
Journal of immunology (Baltimore, Md. : 1950)
Radulovic K,Manta C,Rossini V,Holzmann K,Kestler HA,Wegenka UM,Nakayama T,Niess JH
17-0041 was used in Flow cytometry/Cell sorting to demonstrate that CD69 knockout can modulate mucosal CD4 T cells and increase colitis levels in a mouse transfer model of the disease.
Wed Feb 15 00:00:00 EST 2012
Arsenic trioxide exerts antitumor activity through regulatory T cell depletion mediated by oxidative stress in a murine model of colon cancer.
Journal of immunology (Baltimore, Md. : 1950)
Thomas-Schoemann A,Batteux F,Mongaret C,Nicco C,Chéreau C,Annereau M,Dauphin A,Goldwasser F,Weill B,Lemare F,Alexandre J
17-0041 was used in Flow cytometry/Cell sorting to examine the potential for As(2)O(3) to enhance adoptive immunotherapy strategies in human cancer.
Sat Dec 01 00:00:00 EST 2012
Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasis.
Journal of immunology (Baltimore, Md. : 1950)
Obata Y,Takahashi D,Ebisawa M,Kakiguchi K,Yonemura S,Jinnohara T,Kanaya T,Fujimura Y,Ohmae M,Hase K,Ohno H
17-0041 was used in Flow cytometry/Cell sorting to demonstrate that mice with an IEC-specific deletion in a TF that mediates Notch signalling spontaneously develop colitis.
Thu Mar 01 00:00:00 EST 2012
Requirement for diverse TCR specificities determines regulatory T cell activity in a mouse model of autoimmune arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Oh S,Aitken M,Simons DM,Basehoar A,Garcia V,Kropf E,Caton AJ
17-0041 was used in Flow cytometry/Cell sorting to investigate why CD4(+)CD25(+)Foxp3(+) Tregs allow organ-specific autoimmunity, showing that polyclonal Tregs suppressed Th17 cell formation and prevented arthritis development, but clonotypic Tregs did not, indicating that diverse TCR specificities are required.
Tue May 01 00:00:00 EDT 2012
Epigenetic alterations may regulate temporary reversal of CD4(+) T cell activation caused by trichloroethylene exposure.
Toxicological sciences : an official journal of the Society of Toxicology
Gilbert KM,Nelson AR,Cooney CA,Reisfeld B,Blossom SJ
17-0041 was used in Flow cytometry/Cell sorting to investigate the epigenetic effects of trichloroethylene exposure on the activation state of CD4+ T cells.
Tue May 01 00:00:00 EDT 2012
PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization.
Science signaling
Mahtani-Patching J,Neves JF,Pang DJ,Stoenchev KV,Aguirre-Blanco AM,Silva-Santos B,Pennington DJ
17-0041 was used in Flow cytometry/Cell sorting to demonstrate that signal initiation by preTCR and TCRγδ during thymocyte development does not require regions of the extracellular domains that were implicated in receptor oligomerisation.
Tue Jul 19 00:00:00 EDT 2011
Early secreted antigen ESAT-6 of Mycobacterium tuberculosis promotes protective T helper 17 cell responses in a toll-like receptor-2-dependent manner.
PLoS pathogens
Chatterjee S,Dwivedi VP,Singh Y,Siddiqui I,Sharma P,Van Kaer L,Chattopadhyay D,Das G
17-0041 was used in Flow cytometry/Cell sorting to provide evidence that early secreted antigenic target protein 6, expressed by the virulent M. tb strain H37Rv but not by BCG, promotes vaccine-enhancing Th17 cell responses.
Tue Nov 01 00:00:00 EDT 2011
Functional redundancy between thymic CD8α+ and Sirpα+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins.
Journal of immunology (Baltimore, Md. : 1950)
Atibalentja DF,Murphy KM,Unanue ER
17-0041 was used in Flow cytometry/Cell sorting to evaluate the presentation of blood-derived protein Ags by antigen presenting cells in the thymus.
Tue Feb 01 00:00:00 EST 2011
TRAIL/DR5 plays a critical role in NK cell-mediated negative regulation of dendritic cell cross-priming of T cells.
Journal of immunology (Baltimore, Md. : 1950)
Iyori M,Zhang T,Pantel H,Gagne BA,Sentman CL
17-0041 was used in Flow cytometry/Cell sorting to indicate a novel alternative pathway for DC/NK cell interactions in antitumor immunity.
Thu Sep 15 00:00:00 EDT 2011
The magnitude of CD4(+) T-cell activation rather than TCR diversity determines the outcome of Leishmania infection in mice.
Parasite immunology
Xin L,Wanderley JL,Wang Y,Vargas-Inchaustegui DA,Soong L
17-0041 was used in Flow cytometry/Cell sorting to investigate TCR usage in Leishmania-specific, IFN-γ-producing CD4(+) T cells, showing that the magnitude of activation rather than TCR diversity determines the outcome of infection.
Tue Mar 01 00:00:00 EST 2011
Notch3 is dispensable for thymocyte β-selection and Notch1-induced T cell leukemogenesis.
PloS one
Suliman S,Tan J,Xu K,Kousis PC,Kowalski PE,Chang G,Egan SE,Guidos C
17-0041 was used in Flow cytometry/Cell sorting to assess the essentiality of Notch3 signalling for T cell development and leukaemogenesis.
Tue Feb 28 00:00:00 EST 2012
Ex vivo generation of regulatory T cells: characterization and therapeutic evaluation in a model of chronic colitis.
Methods in molecular biology (Clifton, N.J.)
Karlsson F,Robinson-Jackson SA,Gray L,Zhang S,Grisham MB
17-0041 was used in Flow cytometry/Cell sorting to develop a relatively simple ex vivo method to generate large numbers of Foxp3-expressing iTregs.
Wed Feb 02 00:00:00 EST 2011
Visualization of immune response kinetics in full allogeneic chimeras.
American journal of blood research
Elkin G,Prigozhina TB,Slavin S,Gurevitch O,Khitrin S,Resnick IB
17-0041 was used in Flow cytometry/Cell sorting to visualise the changes in full chimera immune response kinetics after co-transplantation of donor and host hematopoietic cells together.
Thu Aug 23 00:00:00 EDT 2012
The C104R mutant impairs the function of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) through haploinsufficiency.
The Journal of allergy and clinical immunology
Lee JJ,Jabara HH,Garibyan L,Rauter I,Sannikova T,Dillon SR,Bram R,Geha RS
17-0041 was used in Flow cytometry/Cell sorting to investigate the effect of C76R mutations on TACI function in mice.
Wed Dec 01 00:00:00 EST 2010
Replication allows inactivation of a knocked-in locus control region in inappropriate cell lineages.
Proceedings of the National Academy of Sciences of the United States of America
Menzel U,Ktistaki E,Tolaini M,Veiga-Fernandes H,Kioussis D
17-0041 was used in Flow cytometry/Cell sorting to explore the effect of a locus control region on a developmentally regulated locus in the mouse CD8 gene complex.
Tue Sep 28 00:00:00 EDT 2010
The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Pastorino S,Renganathan H,Caliva MJ,Filbert EL,Opoku-Ansah J,Sulzmaier FJ,Gawecka JE,Werlen G,Shaw AS,Ramos JW
17-0041 was used in Flow cytometry/Cell sorting to investigate the physiological function of PEA-15, showing that it negatively regulates T-cell receptor signalling.
Sun Aug 01 00:00:00 EDT 2010
IL-12 suppresses vascular endothelial growth factor receptor 3 expression on tumor vessels by two distinct IFN-gamma-dependent mechanisms.
Journal of immunology (Baltimore, Md. : 1950)
Sorensen EW,Gerber SA,Frelinger JG,Lord EM
17-0041 was used in Flow cytometry/Cell sorting to determine how IL-12 exerts an antiangiogenic effect on tumour blood vessels.
Mon Feb 15 00:00:00 EST 2010
Differential geminin requirement for proliferation of thymocytes and mature T cells.
Journal of immunology (Baltimore, Md. : 1950)
Karamitros D,Kotantaki P,Lygerou Z,Veiga-Fernandes H,Pachnis V,Kioussis D,Taraviras S
17-0041 was used in Flow cytometry/Cell sorting to gain insight into the in vivo role of Geminin in progenitor cell division and differentiation.
Mon Mar 01 00:00:00 EST 2010
Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis.
Journal of immunology (Baltimore, Md. : 1950)
Herbert DR,Orekov T,Roloson A,Ilies M,Perkins C,O'Brien W,Cederbaum S,Christianson DW,Zimmermann N,Rothenberg ME,Finkelman FD
17-0041 was used in Flow cytometry experiments to demonstrate that arginase I produced by alternatively activated macrophages prevents cachexia, neutrophilia, and endotoxemia during acute schistosomiasis.
Tue Jun 01 00:00:00 EDT 2010
Enteric flora expands gut lamina propria CX3CR1+ dendritic cells supporting inflammatory immune responses under normal and inflammatory conditions.
Journal of immunology (Baltimore, Md. : 1950)
Niess JH,Adler G
17-0041 was used in Flow cytometry/Cell sorting to study how the local accumulation of CX3CR1+ dendritic cells may depend on the enteric flora supporting inflammatory immune responses.
Mon Feb 15 00:00:00 EST 2010
Contrasting roles for all-trans retinoic acid in TGF-beta-mediated induction of Foxp3 and Il10 genes in developing regulatory T cells.
The Journal of experimental medicine
Maynard CL,Hatton RD,Helms WS,Oliver JR,Stephensen CB,Weaver CT
17-0041 was used in Flow cytometry/Cell sorting to investigate alternative roles for all-trans retinoic acid in developing regulatory T cells.
Mon Feb 16 00:00:00 EST 2009
Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice.
The Journal of experimental medicine
Gräbner R,Lötzer K,Döpping S,Hildner M,Radke D,Beer M,Spanbroek R,Lippert B,Reardon CA,Getz GS,Fu YX,Hehlgans T,Mebius RE,van der Wall M,Kruspe D,Englert C,Lovas A,Hu D,Randolph GJ,Weih F,Habenicht AJ
17-0041 was used in Flow cytometry/Cell sorting to investigate how the LTbetaR pathway has a major role in shaping the immunological characteristics and overall integrity of the arterial wall.
Fri Jan 16 00:00:00 EST 2009
The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression.
Journal of immunology (Baltimore, Md. : 1950)
Cen O,Ueda A,Guzman L,Jain J,Bassiri H,Nichols KE,Stein PL
17-0041 was used in Flow cytometry/Cell sorting to study the mechanism by which signalling lymphocytic activation molecule-associated protein exerts control over natural killer T cell development and cytokine production.
Sun Feb 01 00:00:00 EST 2009
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation.
Journal of immunology (Baltimore, Md. : 1950)
Lal G,Zhang N,van der Touw W,Ding Y,Ju W,Bottinger EP,Reid SP,Levy DE,Bromberg JS
17-0041 was used in Flow cytometry/Cell sorting to investigate Foxp3 as the master switch for Tregs, showing that expression is regulated by DNA methylation in Tregs.
Thu Jan 01 00:00:00 EST 2009
The survival of memory CD4+ T cells within the gut lamina propria requires OX40 and CD30 signals.
Journal of immunology (Baltimore, Md. : 1950)
Withers DR,Jaensson E,Gaspal F,McConnell FM,Eksteen B,Anderson G,Agace WW,Lane PJL
17-0041 was used in Flow cytometry/Cell sorting to investigate how signals through CD30 and OX40 may be required for the survival of CD4+ T cells within the gut lamina propria.
Thu Oct 15 00:00:00 EDT 2009
Distinct roles for MyD88 and Toll-like receptor 2 during Leishmania braziliensis infection in mice.
Infection and immunity
Vargas-Inchaustegui DA,Tai W,Xin L,Hogg AE,Corry DB,Soong L
17-0041 was used in Flow cytometry/Cell sorting to investigate whether TLRs are involved in L. braziliensis-mediated dendritic cell activation, showing distinct roles for MyD88 and TLR2 in infection.
Wed Jul 01 00:00:00 EDT 2009
Mechanism of T cell tolerance induction by murine hepatic Kupffer cells.
Hepatology (Baltimore, Md.)
You Q,Cheng L,Kedl RM,Ju C
17-0041 was used in Flow cytometry/Cell sorting to examine the ability of Kupffer cells to present antigens and to suppress T cell activation by splenic dendritic cells.
Mon Sep 01 00:00:00 EDT 2008
Defective positive selection results in T cell lymphopenia and increased autoimmune diabetes in ADAP-deficient BDC2.5-C57BL/6 mice.
European journal of immunology
Zou L,Mendez F,Martin-Orozco N,Peterson EJ
17-0041 was used in Flow cytometry/Cell sorting to investigate the role of ADAP in a T cell-driven autoimmune response, showing that deficiency leads to defective positive selection in T cell lymphopenia and increased autoimmune diabetes.
Tue Apr 01 00:00:00 EDT 2008
Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome.
The American journal of pathology
Gongora MC,Lob HE,Landmesser U,Guzik TJ,Martin WD,Ozumi K,Wall SM,Wilson DS,Murthy N,Gravanis M,Fukai T,Harrison DG
17-0041 was used in Flow cytometry/Cell sorting to study the role of acute SOD3 reduction in lung injury.
Wed Oct 01 00:00:00 EDT 2008
Inhalation of Staphylococcus aureus enterotoxin A induces IFN-gamma and CD8 T cell-dependent airway and interstitial lung pathology in mice.
Journal of immunology (Baltimore, Md. : 1950)
Muralimohan G,Rossi RJ,Guernsey LA,Thrall RS,Vella AT
17-0041 was used in Flow cytometry/Cell sorting to investigate molecular mediators involved in bacterial superantigen-mediated pulmonary disease, showing that inhalation induces IFN-gamma and CD8 T cell-dependent airway and interstitial lung pathology.
Mon Sep 01 00:00:00 EDT 2008
Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.
Investigative ophthalmology & visual science
Mochimaru H,Usui T,Yaguchi T,Nagahama Y,Hasegawa G,Usui Y,Shimmura S,Tsubota K,Amano S,Kawakami Y,Ishida S
Thu May 01 00:00:00 EDT 2008
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla.
The Journal of experimental medicine
Rossi SW,Kim MY,Leibbrandt A,Parnell SM,Jenkinson WE,Glanville SH,McConnell FM,Scott HS,Penninger JM,Jenkinson EJ,Lane PJ,Anderson G
17-0041 was used in Flow cytometry/Cell sorting to demonstrate a novel role for a CD4(+)3(-) inducer cell population, showing that RANK signals regulate development of Aire-expressing epithelial cells in the thymic medulla.
Mon Jun 11 00:00:00 EDT 2007
Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.
Circulation
Yang Z,Day YJ,Toufektsian MC,Xu Y,Ramos SI,Marshall MA,French BA,Linden J
Tue Nov 07 00:00:00 EST 2006
An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes.
International immunology
Tellier J,van Meerwijk JP,Romagnoli P
17-0041 was used in Flow cytometry/Cell sorting to investigate factors that affect the levels of Tregs in the thymus.
Wed Nov 01 00:00:00 EST 2006
Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling.
Genes & development
Taghon TN,David ES,Zúñiga-Pflücker JC,Rothenberg EV
17-0041 was used in Flow cytometry/Cell sorting to study how Notch/Delta signaling is not sufficient for T-lineage specification and commitment, but can be permissive for the maintenance and proliferation of uncommitted progenitors.
Fri Apr 15 00:00:00 EDT 2005
Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis.
The Journal of experimental medicine
Rifa'i M,Kawamoto Y,Nakashima I,Suzuki H
17-0041 was used in Flow cytometry/Cell sorting to investigate the effect of transfer of CD8+CD122+ cells into CD122-deficient neonates, showing that CD8+CD122+ regulatory T cells are essential for T cell homeostasis.
Mon Nov 01 00:00:00 EST 2004
