Product References
HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway.
Journal of experimental & clinical cancer research : CR
Liu Y,Xu Q,Deng F,Zheng Z,Luo J,Wang P,Zhou J,Lu X,Zhang L,Chen Z,Zhang Q,Chen Q,Zuo D
14-0289-82 was used in Cell Culture to identify HERC2 functions as a previously unknown modulator of the JAK2/STAT3 pathway, thereby promoting inflammation-induced stemness and immune evasion in HCC.
Wed Feb 01 00:00:00 EST 2023
CHI3L1 enhances melanoma lung metastasis via regulation of T cell co-stimulators and CTLA-4/B7 axis.
Frontiers in immunology
Ma B,Kamle S,Akosman B,Khan H,Lee CM,Lee CG,Elias JA
Published figure using CD28 monoclonal antibody (Product # 14-0289-82) in Flow Cytometry
Tue Jan 10 00:00:00 EST 2023
Combination of Expanded Allogeneic NK Cells and T Cell-Based Immunotherapy Exert Enhanced Antitumor Effects.
Cancers
Wang X,Yang X,Wang Y,Chen Y,Yang Y,Shang S,Wang W,Wang Y
14-0289-82 was used in Cell Culture to develop an efficient manufacturing system that relies on genetically modified K562 cells for the expansion of high-quality NK cells derived from peripheral blood mononuclear cells.
Fri Dec 30 00:00:00 EST 2022
Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.
Cell
Béziat V,Rapaport F,Hu J,Titeux M,Bonnet des Claustres M,Bourgey M,Griffin H,Bandet É,Ma CS,Sherkat R,Rokni-Zadeh H,Louis DM,Changi-Ashtiani M,Delmonte OM,Fukushima T,Habib T,Guennoun A,Khan T,Bender N,Rahman M,About F,Yang R,Rao G,Rouzaud C,Li J,Shearer D,Balogh K,Al Ali F,Ata M,Dabiri S,Momenilandi M,Nammour J,Alyanakian MA,Leruez-Ville M,Guenat D,Materna M,Marcot L,Vladikine N,Soret C,Vahidnezhad H,Youssefian L,Saeidian AH,Uitto J,Catherinot É,Navabi SS,Zarhrate M,Woodley DT,Jeljeli M,Abraham T,Belkaya S,Lorenzo L,Rosain J,Bayat M,Lanternier F,Lortholary O,Zakavi F,Gros P,Orth G,Abel L,Prétet JL,Fraitag S,Jouanguy E,Davis MM,Tangye SG,Notarangelo LD,Marr N,Waterboer T,Langlais D,Doorbar J,Hovnanian A,Christensen N,Bossuyt X,Shahrooei M,Casanova JL
14-0289-82 was used in Flow cytometry/Cell sorting to conclude that human CD28-dependent T cell responses are largely redundant for protective immunity.
Thu Jul 08 00:00:00 EDT 2021
Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19.
Immunity
Szabo PA,Dogra P,Gray JI,Wells SB,Connors TJ,Weisberg SP,Krupska I,Matsumoto R,Poon MML,Idzikowski E,Morris SE,Pasin C,Yates AJ,Ku A,Chait M,Davis-Porada J,Guo XV,Zhou J,Steinle M,Mackay S,Saqi A,Baldwin MR,Sims PA,Farber DL
Published figure using CD28 monoclonal antibody (Product # 14-0289-82) in Flow Cytometry
Tue Apr 13 00:00:00 EDT 2021
Effects of the Antidiabetic Drugs Evogliptin and Sitagliptin on the Immune Function of CD26/DPP4 in Th1 Cells.
Biomolecules & therapeutics
Yoon H,Sung JH,Song MJ
Published figure using CD28 monoclonal antibody (Product # 14-0289-82) in Flow Cytometry
Mon Mar 01 00:00:00 EST 2021
CD19 Chimeric Antigen Receptor-Exosome Targets CD19 Positive B-lineage Acute Lymphocytic Leukemia and Induces Cytotoxicity.
Cancers
Haque S,Vaiselbuh SR
Published figure using CD28 monoclonal antibody (Product # 14-0289-82) in Flow Cytometry
Fri Mar 19 00:00:00 EDT 2021
Differences in Maturation Status and Immune Phenotypes of Circulating Helios+ and Helios- Tregs and Their Disrupted Correlations With Monocyte Subsets in Autoantibody-Positive T1D Individuals.
Frontiers in immunology
Zhang Y,Zhang J,Shi Y,Shen M,Lv H,Chen S,Feng Y,Chen H,Xu X,Yang T,Xu K
14-0289-82 was used in Flow Cytometry to explore the immunological changes in circulating Helios+ and Helios- regulator T-cells in type 1 diabetes.
Wed Sep 15 00:00:00 EDT 2021
Differences in Maturation Status and Immune Phenotypes of Circulating Helios+ and Helios- Tregs and Their Disrupted Correlations With Monocyte Subsets in Autoantibody-Positive T1D Individuals.
Frontiers in immunology
Zhang Y,Zhang J,Shi Y,Shen M,Lv H,Chen S,Feng Y,Chen H,Xu X,Yang T,Xu K
14-0289-82 was used in Flow Cytometry to explore the immunological changes in circulating Helios+ and Helios- regulator T-cells in type 1 diabetes.
Wed Sep 15 00:00:00 EDT 2021
SIRT1 is downregulated by autophagy in senescence and ageing.
Nature cell biology
Xu C,Wang L,Fozouni P,Evjen G,Chandra V,Jiang J,Lu C,Nicastri M,Bretz C,Winkler JD,Amaravadi R,Garcia BA,Adams PD,Ott M,Tong W,Johansen T,Dou Z,Berger SL
Published figure using CD28 monoclonal antibody (Product # 14-0289-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.
The Journal of cell biology
Xu X,Hou B,Fulzele A,Masubuchi T,Zhao Y,Wu Z,Hu Y,Jiang Y,Ma Y,Wang H,Bennett EJ,Fu G,Hui E
Published figure using CD28 monoclonal antibody (Product # 14-0289-82) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2020
Expression of CD27 and CD28 on γδ T cells from the peripheral blood of patients with allergic rhinitis.
Experimental and therapeutic medicine
Wang Q,Sun Q,Chen Q,Li H,Liu D
Published figure using CD28 monoclonal antibody (Product # 14-0289-82) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2020
Human Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence.
Cell reports
Swadling L,Pallett LJ,Diniz MO,Baker JM,Amin OE,Stegmann KA,Burton AR,Schmidt NM,Jeffery-Smith A,Zakeri N,Suveizdyte K,Froghi F,Fusai G,Rosenberg WM,Davidson BR,Schurich A,Simon AK,Maini MK
Published figure using CD28 monoclonal antibody (Product # 14-0289-82) in T-Cell Activation
Tue Jan 21 00:00:00 EST 2020
Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis.
Cancers
Darvekar S,Juzenas P,Oksvold M,Kleinauskas A,Holien T,Christensen E,Stokke T,Sioud M,Peng Q
Published figure using CD28 monoclonal antibody (Product # 14-0289-82) in Flow Cytometry
Thu Feb 06 00:00:00 EST 2020
RAB11FIP5-Deficient Mice Exhibit Cytokine-Related Transcriptomic Signatures.
ImmunoHorizons
Li D,Bradley T,Cain DW,Pedroza-Pacheco I,Aggelakopoulou M,Parks R,Barr M,Xia SM,Scearce R,Bowman C,Stevens G,Newman A,Hora B,Chen Y,Riebe K,Wang Y,Sempowski G,Saunders KO,Borrow P,Haynes BF
Published figure using CD28 monoclonal antibody (Product # 14-0289-82) in Functional assay
Tue Nov 10 00:00:00 EST 2020
Repositioning liothyronine for cancer immunotherapy by blocking the interaction of immune checkpoint TIGIT/PVR.
Cell communication and signaling : CCS
Zhou X,Du J,Wang H,Chen C,Jiao L,Cheng X,Zhou X,Chen S,Gou S,Zhao W,Zhai W,Chen J,Gao Y
14-0289 was used in Flow cytometry/Cell sorting to discover how liothyronine could serve as a potential candidate for cancer immunotherapy by blocking the immune checkpoint TIGIT/PVR.
Mon Sep 07 00:00:00 EDT 2020
Intratumoral interleukin-9 delineates a distinct immunogenic class of gastric cancer patients with better prognosis and adjuvant chemotherapeutic response.
Oncoimmunology
Fang H,Li R,Gu Y,Fei Y,Jin K,Chen Y,Cao Y,Liu X,Lv K,Wang J,Yu K,Lin C,Liu H,Li H,He H,Zhang W,Zhang H,Shen Z
14-0289-82 was used in In vitro Assay to suggest that IL-9 expression could act as an independent predictor for overall survival and ACT response and enhancing IL-9 signaling might represent an important therapeutic strategy in gastric cancer.
Tue Dec 15 00:00:00 EST 2020
The effect of smoking on chronic inflammation, immune function and blood cell composition.
Scientific reports
Elisia I,Lam V,Cho B,Hay M,Li MY,Yeung M,Bu L,Jia W,Norton N,Lam S,Krystal G
14-0289-82 was used in Functional assay to evaluate the effects of smoking on inflammatory markers, innate and adaptive immune responses to bacterial and viral challenges and blood cell composition.
Tue Nov 10 00:00:00 EST 2020
Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion.
Nature immunology
Sawant DV,Yano H,Chikina M,Zhang Q,Liao M,Liu C,Callahan DJ,Sun Z,Sun T,Tabib T,Pennathur A,Corry DB,Luketich JD,Lafyatis R,Chen W,Poholek AC,Bruno TC,Workman CJ,Vignali DAA
14-0289-82 was used in T-Cell Activation to reveal previously unappreciated cooperative roles for Treg cell-derived IL-10 and IL-35 in promoting BLIMP1-dependent exhaustion of CD8+ TILs that limits effective anti-tumor immunity.
Sat Jun 01 00:00:00 EDT 2019
Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3.
Journal for immunotherapy of cancer
Trovato R,Fiore A,Sartori S,Canè S,Giugno R,Cascione L,Paiella S,Salvia R,De Sanctis F,Poffe O,Anselmi C,Hofer F,Sartoris S,Piro G,Carbone C,Corbo V,Lawlor R,Solito S,Pinton L,Mandruzzato S,Bassi C,Scarpa A,Bronte V,Ugel S
14-0289 was used in Flow cytometry/Cell sorting to report that PDAC patients show increased levels of both circulating and tumor-infiltrating MDSC-like cells.
Wed Sep 18 00:00:00 EDT 2019
Antisense oligonucleotide targeting CD39 improves anti-tumor T cell immunity.
Journal for immunotherapy of cancer
Kashyap AS,Thelemann T,Klar R,Kallert SM,Festag J,Buchi M,Hinterwimmer L,Schell M,Michel S,Jaschinski F,Zippelius A
14-0289-82 was used in Flow Cytometry to targeting of CD39 by ASOs represents a promising state-of-the art therapeutic approach to improve immune responses against tumors.
Tue Mar 12 00:00:00 EDT 2019
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade.
Nature medicine
Thommen DS,Koelzer VH,Herzig P,Roller A,Trefny M,Dimeloe S,Kiialainen A,Hanhart J,Schill C,Hess C,Savic Prince S,Wiese M,Lardinois D,Ho PC,Klein C,Karanikas V,Mertz KD,Schumacher TN,Zippelius A
14-0289 was used in Flow cytometry/Cell sorting to compare transcriptional, metabolic and functional signatures of intratumoral CD8+ T lymphocyte populations with high, intermediate and no PD-1 expression from non-small-cell lung cancer patients.
Sun Jul 01 00:00:00 EDT 2018
Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1.
The Journal of experimental medicine
Jeng MY,Hull PA,Fei M,Kwon HS,Tsou CL,Kasler H,Ng CP,Gordon DE,Johnson J,Krogan N,Verdin E,Ott M
Published figure using CD28 monoclonal antibody (Product # 14-0289-82) in Flow Cytometry
Tue Jan 02 00:00:00 EST 2018
Systemic surfaceome profiling identifies target antigens for immune-based therapy in subtypes of advanced prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America
Lee JK,Bangayan NJ,Chai T,Smith BA,Pariva TE,Yun S,Vashisht A,Zhang Q,Park JW,Corey E,Huang J,Graeber TG,Wohlschlegel J,Witte ON
Tue May 08 00:00:00 EDT 2018
Multiple Homozygous Variants in the STING-Encoding TMEM173 Gene in HIV Long-Term Nonprogressors.
Journal of immunology (Baltimore, Md. : 1950)
Nissen SK,Pedersen JG,Helleberg M,Kjær K,Thavachelvam K,Obel N,Tolstrup M,Jakobsen MR,Mogensen TH
14-0289 was used in Functional assays to examine the presence and possible immunological role of multiple homozygous single-nucleotide polymorphisms in the stimulator of IFN genes (STING) encoding gene TMEM173 involved in IFN induction and T cell proliferation in HIV LTNP patients.
Tue May 15 00:00:00 EDT 2018
FUNDAMANT: an interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer's disease.
Alzheimer's research & therapy
Novak P,Schmidt R,Kontsekova E,Kovacech B,Smolek T,Katina S,Fialova L,Prcina M,Parrak V,Dal-Bianco P,Brunner M,Staffen W,Rainer M,Ondrus M,Ropele S,Smisek M,Sivak R,Zilka N,Winblad B,Novak M
14-0289 was used in Flow cytometry/Cell sorting to follow-up on patients following a 24-week phase 1 trial on the active vaccine AADvac1 against pathological tau protein.
Wed Oct 24 00:00:00 EDT 2018
Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3.
BMC biology
Schmidt A,Marabita F,Kiani NA,Gross CC,Johansson HJ,Éliás S,Rautio S,Eriksson M,Fernandes SJ,Silberberg G,Ullah U,Bhatia U,Lähdesmäki H,Lehtiö J,Gomez-Cabrero D,Wiendl H,Lahesmaa R,Tegnér J
14-0289 was used in Flow cytometry/Cell sorting to study the mechanisms underlying Treg differentiation and the regulation of FOXP3.
Mon May 07 00:00:00 EDT 2018
Beyond Type 1 Regulatory T Cells: Co-expression of LAG3 and CD49b in IL-10-Producing T Cell Lineages.
Frontiers in immunology
Huang W,Solouki S,Carter C,Zheng SG,August A
14-0289 was used in Sample Preparation to investigate the co-expression of LAG3 and CD49b in IL-10-producing T Cell lineages.
Tue Oct 08 00:00:00 EDT 2019
Immunophenotypic characterization of human T cells after in vitro exposure to different silicone breast implant surfaces.
PloS one
Cappellano G,Ploner C,Lobenwein S,Sopper S,Hoertnagl P,Mayerl C,Wick N,Pierer G,Wick G,Wolfram D
14-0289 was used in Flow cytometry/Cell sorting to study the immune response of human peripheral blood mononuclear cells (PBMC) to silicone breast implants.
Mon Mar 19 00:00:00 EDT 2018
Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens.
Nature
Khodadoust MS,Olsson N,Wagar LE,Haabeth OA,Chen B,Swaminathan K,Rawson K,Liu CL,Steiner D,Lund P,Rao S,Zhang L,Marceau C,Stehr H,Newman AM,Czerwinski DK,Carlton VE,Moorhead M,Faham M,Kohrt HE,Carette J,Green MR,Davis MM,Levy R,Elias JE,Alizadeh AA
14-0289 was used in Flow cytometry/Cell sorting to demonstrate that an integrative approach combining major histocompatibility complex isolation, peptide identification, and exome sequencing is an effective platform to uncover tumour neoantigens.
Thu Mar 30 00:00:00 EDT 2017
Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells.
The Journal of allergy and clinical immunology
Chen HH,Händel N,Ngeow J,Muller J,Hühn M,Yang HT,Heindl M,Berbers RM,Hegazy AN,Kionke J,Yehia L,Sack U,Bläser F,Rensing-Ehl A,Reifenberger J,Keith J,Travis S,Merkenschlager A,Kiess W,Wittekind C,Walker L,Ehl S,Aretz S,Dustin ML,Eng C,Powrie F,Uhlig HH
14-0289 was used in Flow cytometry/Cell sorting to investigate Treg cells in patients with heterozygous germline PTEN mutations, showing a significant effect on T- and B-cell immunity.
Wed Feb 01 00:00:00 EST 2017
Differentially Expressed Potassium Channels Are Associated with Function of Human Effector Memory CD8+ T Cells.
Frontiers in immunology
Sim JH,Kim KS,Park H,Kim KJ,Lin H,Kim TJ,Shin HM,Kim G,Lee DS,Park CW,Lee DH,Kang I,Kim SJ,Cho CH,Doh J,Kim HR
14-0289 was used in Flow cytometry to suggest that IL-7RαhighEM CD8+T cells with functional potassium channels may be a reservoir for effector CD8+T cells during peripheral inflammation.
Wed Nov 20 00:00:00 EST 2019
CD4 T-Cell Dysregulation in Psoriatic Arthritis Reveals a Regulatory Role for IL-22.
Frontiers in immunology
Ezeonyeji A,Baldwin H,Vukmanovic-Stejic M,Ehrenstein MR
14-0289 was used in Flow cytometry/Cell sorting to examine the role of IL-22 in patients with psoriatic arthritis (PsA).
Sat Jan 09 00:00:00 EST 2021
T-cell responses targeting HIV Nef uniquely correlate with infected cell frequencies after long-term antiretroviral therapy.
PLoS pathogens
Thomas AS,Jones KL,Gandhi RT,McMahon DK,Cyktor JC,Chan D,Huang SH,Truong R,Bosque A,Macedo AB,Kovacs C,Benko E,Eron JJ,Bosch RJ,Lalama CM,Simmens S,Walker BD,Mellors JW,Jones RB
14-0289 was used in Functional assays to investigate whether HIV antigen recognition persists in antiretroviral therapy-treated individuals due to low-level or episodic protein expression.
Fri Sep 01 00:00:00 EDT 2017
D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes.
Molecular and cellular biology
Witte A,Meineke B,Sticht J,Philipsen L,Kuropka B,Müller AJ,Freund C,Schraven B,Kliche S
14-0289 was used in in vitro experiments to gain an understanding of how Src kinase-associated phosphoprotein (SKAP55) controls TCR-mediated β2-integrin lymphocyte function-associated antigen 1 (LFA-1) activation.
Sat Apr 01 00:00:00 EDT 2017
Frequency of CD4+CD161+ T Cell and Interleukin-10 Expression in Inflammatory Bowel Diseases.
Acta histochemica et cytochemica
Tsuchiya K,Ikeda T,Batmunkh B,Choijookhuu N,Ishizaki H,Hotokezaka M,Hishikawa Y,Nanashima A
14-0289 was used in Flow cytometry/Cell sorting to investigate the expression of CD4(+)CD161(+) T cells and IL-10 in inflammatory bowel disease patients.
Tue Feb 28 00:00:00 EST 2017
A human immunodeficiency syndrome caused by mutations in CARMIL2.
Nature communications
Schober T,Magg T,Laschinger M,Rohlfs M,Linhares ND,Puchalka J,Weisser T,Fehlner K,Mautner J,Walz C,Hussein K,Jaeger G,Kammer B,Schmid I,Bahia M,Pena SD,Behrends U,Belohradsky BH,Klein C,Hauck F
14-0289 was used in Flow cytometry/Cell sorting to show that human CARMIL2-deficiency is associated with defective CD28-mediated TCR co-signalling and impaired cytoskeletal dynamics.
Mon Jan 23 00:00:00 EST 2017
ITK signalling via the Ras/IRF4 pathway regulates the development and function of Tr1 cells.
Nature communications
Huang W,Solouki S,Koylass N,Zheng SG,August A
14-0289 was used in Flow cytometry/Cell sorting to report findings for the functional development of type 1 regulatory T cells by TCR/ITK signalling.
Wed Jun 21 00:00:00 EDT 2017
Down-regulation of microRNA-451a facilitates the activation and proliferation of CD4+ T cells by targeting Myc in patients with dilated cardiomyopathy.
The Journal of biological chemistry
Zeng Z,Wang K,Li Y,Xia N,Nie S,Lv B,Zhang M,Tu X,Li Q,Tang T,Cheng X
Fri Apr 07 00:00:00 EDT 2017
MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential.
Oncoimmunology
Tigue NJ,Bamber L,Andrews J,Ireland S,Hair J,Carter E,Sridharan S,Jovanović J,Rees DG,Springall JS,Solier E,Li YM,Chodorge M,Perez-Martinez D,Higazi DR,Oberst M,Kennedy M,Black CM,Yan L,Schwickart M,Maguire S,Cann JA,de Haan L,Young LL,Vaughan T,Wilkinson RW,Stewart R
14-0289 was used in Flow cytometry/Cell sorting to design an effective agonist of human glucocorticoid-induced tumour necrosis factor for use as a potential cancer therapy.
Tue Jan 12 00:00:00 EST 2021
Functional characterization of T-cells from palatine tonsils in patients with chronic tonsillitis.
PloS one
Geißler K,Markwart R,Requardt RP,Weigel C,Schubert K,Scherag A,Rubio I,Guntinas-Lichius O
14-0289 was used in Flow cytometry/Cell sorting to analyse and characterise the response of tonsillar T-cells from chronic tonsillitis to antigenic stimulation.
Mon Oct 16 00:00:00 EDT 2017
Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF-TNF-RII binding in rheumatoid arthritis.
The Journal of experimental medicine
Nguyen DX,Ehrenstein MR
14-0289 was used in Functional assays to investigate whether TNF boosts of inhibits regulatory T cells (T reg cells), showing that anti-TNF drives regulatory T cell expansion by promoting membrane TNF-TNF-RII binding, in rheumatoid arthritis.
Mon Jun 27 00:00:00 EDT 2016
Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF-TNF-RII binding in rheumatoid arthritis.
The Journal of experimental medicine
Nguyen DX,Ehrenstein MR
14-0289 was used in Functional assays to investigate whether TNF boosts of inhibits regulatory T cells (T reg cells), showing that anti-TNF drives regulatory T cell expansion by promoting membrane TNF-TNF-RII binding, in rheumatoid arthritis.
Mon Jun 27 00:00:00 EDT 2016
Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment.
PLoS pathogens
Bender RR,Muth A,Schneider IC,Friedel T,Hartmann J,Plückthun A,Maisner A,Buchholz CJ
14-0289 was used in Functional assays to demonstrate that pseudotyping of lentiviral vectors (LVs) with receptor-targeted Nipah virus glycoproteins is an effective LV gene delivery strategy to specific cells.
Wed Jun 01 00:00:00 EDT 2016
Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation.
PLoS pathogens
Abdel-Mohsen M,Chavez L,Tandon R,Chew GM,Deng X,Danesh A,Keating S,Lanteri M,Samuels ML,Hoh R,Sacha JB,Norris PJ,Niki T,Shikuma CM,Hirashima M,Deeks SG,Ndhlovu LC,Pillai SK
14-0289 was used in Functional assays to investigate whether galectin-9 modulates HIV transcription, showing that it is a potent mediator of HIV transcription and reactivation.
Wed Jun 01 00:00:00 EDT 2016
The Distribution of Human Stem Cell-like Memory T Cell in Lung Cancer.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Hong H,Gu Y,Sheng SY,Lu CG,Zou JY,Wu CY
Published figure using CD28 monoclonal antibody (Product # 14-0289-82) in Flow Cytometry
Thu Jan 04 00:00:00 EST 2018
CD28 family of receptors on T cells in chronic HBV infection: Expression characteristics, clinical significance and correlations with PD-1 blockade.
Molecular medicine reports
Tang ZS,Hao YH,Zhang EJ,Xu CL,Zhou Y,Zheng X,Yang DL
Published figure using CD28 monoclonal antibody (Product # 14-0289-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
Effect of cytokine-induced killer cells on immune function in patients with lung cancer.
Oncology letters
Pan Y,Wu Y,Ji J,Cai H,Wang H,Jiang Y,Sang L,Yang J,Gao Y,Liu Y,Yin L,Zhang LI
14-0289 was used in Functional assays to evaluate the effect of cytokine-induced killer cells on immune function in lung cancer patients.
Fri Apr 01 00:00:00 EDT 2016
Non-random pairing of CD46 isoforms with skewing towards BC2 and C2 in activated and memory/effector T cells.
Scientific reports
Hansen AS,Bundgaard BB,Møller BK,Höllsberg P
14-0289 was used in Flow cytometry/Cell sorting to suggest a mechanism by which alterations in CD46 isoforms may temporarily regulate the immune response.
Fri Oct 14 00:00:00 EDT 2016
Follicular Lymphoma Tregs Have a Distinct Transcription Profile Impacting Their Migration and Retention in the Malignant Lymph Node.
PloS one
Nedelkovska H,Rosenberg AF,Hilchey SP,Hyrien O,Burack WR,Quataert SA,Baker CM,Azadniv M,Welle SL,Ansell SM,Kim M,Bernstein SH
14-0289 was used in Functional assays to study the unique number, phenotype, and function of follicular lymphoma nodal regulatory T cells.
Mon Jul 10 00:00:00 EDT 2017
IL-7 Induces SAMHD1 Phosphorylation in CD4+ T Lymphocytes, Improving Early Steps of HIV-1 Life Cycle.
Cell reports
Coiras M,Bermejo M,Descours B,Mateos E,García-Pérez J,López-Huertas MR,Lederman MM,Benkirane M,Alcamí J
14-0289 was used in Functional assays to investigate the mechanisms involved in the establishment of latent HIV-1 virus reservoirs.
Tue Mar 08 00:00:00 EST 2016
Combining FoxP3 and Helios with GARP/LAP markers can identify expanded Treg subsets in cancer patients.
Oncotarget
Abd Al Samid M,Chaudhary B,Khaled YS,Ammori BJ,Elkord E
14-0289 was used in in vitro experiments to demonstrate that studying a combination of Treg-specific markers could be used to more accurately determine expanded Treg subsets and to understand their contribution in cancer settings.
Tue Mar 22 00:00:00 EDT 2016
A key role of GARP in the immune suppressive tumor microenvironment.
Oncotarget
Hahn SA,Neuhoff A,Landsberg J,Schupp J,Eberts D,Leukel P,Bros M,Weilbaecher M,Schuppan D,Grabbe S,Tueting T,Lennerz V,Sommer C,Jonuleit H,Tuettenberg A
14-0289 was used in Functional assays to show that the Treg activation marker GARP is expressed on human primary melanoma.
Tue Jul 12 00:00:00 EDT 2016
Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation.
Proceedings of the National Academy of Sciences of the United States of America
Green MR,Kihira S,Liu CL,Nair RV,Salari R,Gentles AJ,Irish J,Stehr H,Vicente-Dueñas C,Romero-Camarero I,Sanchez-Garcia I,Plevritis SK,Arber DA,Batzoglou S,Levy R,Alizadeh AA
14-0289 was used in Flow cytometry/Cell sorting to suggest a role for the CREBBP in contributing to immune evasion via decreased antigen presentation in follicular lymphomas.
Tue Mar 10 00:00:00 EDT 2015
PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer.
Cancer immunology research
Severson JJ,Serracino HS,Mateescu V,Raeburn CD,McIntyre RC,Sams SB,Haugen BR,French JD
14-0289 was used in Functional assays to determine that the release of PD-1 and Tim-3, and the inhibition of Tregs, may encourage tumour elimination in metastatic differentiated thyroid cancer.
Mon Jun 01 00:00:00 EDT 2015
Induced PD-L1 expression mediates acquired resistance to agonistic anti-CD40 treatment.
Cancer immunology research
Zippelius A,Schreiner J,Herzig P,Müller P
14-0289 was used in Flow cytometry/Cell sorting to uncover a novel mechanism of acquired resistance to agonistic CD40 stimulation in tumours, and show how this mechanism can be successfully circumvented.
Sun Mar 01 00:00:00 EST 2015
Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers.
Journal of virology
Walker WE,Kurscheid S,Joshi S,Lopez CA,Goh G,Choi M,Barakat L,Francis J,Fisher A,Kozal M,Zapata H,Shaw A,Lifton R,Sutton RE,Fikrig E
14-0289 was used in Flow cytometry/Cell sorting to examine CD4(+) T cell resistance to HIV in a group of elite controllers.
Fri May 01 00:00:00 EDT 2015
Monocyte:T-cell interaction regulates human T-cell activation through a CD28/CD46 crosstalk.
Immunology and cell biology
Charron L,Doctrinal A,Ni Choileain S,Astier AL
14-0289-82 was used in Functional assay to identify a crosstalk between two main costimulatory pathways and provide novel insights into the regulation of human T-cell activation.
Thu Oct 01 00:00:00 EDT 2015
Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus.
Arthritis research & therapy
Sim JH,Kim HR,Chang SH,Kim IJ,Lipsky PE,Lee J
14-0289 was used in Functional assays to determine that IL-10 can regulate the immune capacity of pre-naïve B cells and their ability to enhance the development of autoimmunity.
Sat Jul 25 00:00:00 EDT 2015
Immunodeficiency and autoimmune enterocolopathy linked to NFAT5 haploinsufficiency.
Journal of immunology (Baltimore, Md. : 1950)
Boland BS,Widjaja CE,Banno A,Zhang B,Kim SH,Stoven S,Peterson MR,Jones MC,Su HI,Crowe SE,Bui JD,Ho SB,Okugawa Y,Goel A,Marietta EV,Khosroheidari M,Jepsen K,Aramburu J,López-Rodríguez C,Sandborn WJ,Murray JA,Harismendy O,Chang JT
14-0289 was used in Functional assays to study the immune cell populations of a young man with autoimmune enterocolopathy and unexplained infections.
Sun Mar 15 00:00:00 EDT 2015
Cutting edge: circulating plasmablasts induce the differentiation of human T follicular helper cells via IL-6 production.
Journal of immunology (Baltimore, Md. : 1950)
Chavele KM,Merry E,Ehrenstein MR
14-0289 was used in Flow cytometry/Cell sorting to identify a reciprocal interaction between circulating human plasmablasts and Tfh cells which drives Tfh cell differentiation.
Sun Mar 15 00:00:00 EDT 2015
The Nrf2 activator tBHQ inhibits T cell activation of primary human CD4 T cells.
Cytokine
Turley AE,Zagorski JW,Rockwell CE
14-0289 was used in Functional assays to investigate the effect of Nrf2 on human immune cells, showing that the Nrf2 activator tBHQ inhibits T cell activation.
Sun Feb 01 00:00:00 EST 2015
The APPEESFRS Peptide, Restricted by the HLA-B*35:01 Molecule, and the APPEESFRF Variant Derived from an Autologous HIV-1 Strain Induces Polyfunctional Responses in CD8+ T Cells.
BioResearch open access
Acevedo-Sáenz L,Carmona-Pérez L,Velilla-Hernández PA,Delgado JC,Rugeles L MT
14-0289 was used in Flow cytometry/Cell sorting to determine the effector profile and maturation phenotype of CD8+ T-cells targeting the consensus APPEESFRS (AS9) epitope and its variant APPEESFRF (AF9).
Fri Aug 28 00:00:00 EDT 2015
Vaccination Expands Antigen-Specific CD4+ Memory T Cells and Mobilizes Bystander Central Memory T Cells.
PloS one
Li Causi E,Parikh SC,Chudley L,Layfield DM,Ottensmeier CH,Stevenson FK,Di Genova G
14-0289-82 was used in Flow Cytometry to compare the differentiation, function, activation and proliferative status of blood vaccine-specific and bystander CD4+ T helper memory cells.
Mon May 23 00:00:00 EDT 2016
Murine K2P5.1 Deficiency Has No Impact on Autoimmune Neuroinflammation due to Compensatory K2P3.1- and KV1.3-Dependent Mechanisms.
International journal of molecular sciences
Bittner S,Bobak N,Hofmann MS,Schuhmann MK,Ruck T,Göbel K,Brück W,Wiendl H,Meuth SG
14-0289 was used in Functional assays to investigate the effect of K2P5.1 knockout on T cells.
Fri Jul 24 00:00:00 EDT 2015
Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes.
PLoS pathogens
Jones RB,O'Connor R,Mueller S,Foley M,Szeto GL,Karel D,Lichterfeld M,Kovacs C,Ostrowski MA,Trocha A,Irvine DJ,Walker BD
14-0289 was used in Flow cytometry/Cell sorting to study the impact of three histone deacetylase inhibitors in clinical development on T-cell effector functions.
Fri Aug 01 00:00:00 EDT 2014
NKG2D- and CD28-mediated costimulation regulate CD8+ T cell chemotaxis through different mechanisms: the role of Cdc42/N-WASp.
Journal of leukocyte biology
Serrano-Pertierra E,Cernuda-Morollón E,López-Larrea C
14-0289 was used in Functional assays to analyse the function of the NKG2D receptor in human CD8(+) T cell chemotaxis toward a CXCL12 gradient.
Sat Mar 01 00:00:00 EST 2014
Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans.
Journal of immunology (Baltimore, Md. : 1950)
Wertheimer AM,Bennett MS,Park B,Uhrlaub JL,Martinez C,Pulko V,Currier NL,Nikolich-Žugich D,Kaye J,Nikolich-Žugich J
Published figure using CD28 monoclonal antibody (Product # 14-0289-82) in Flow Cytometry
Sat Mar 01 00:00:00 EST 2014
N-glycosylation of asparagine 8 regulates surface expression of major histocompatibility complex class I chain-related protein A (MICA) alleles dependent on threonine 24.
The Journal of biological chemistry
Mellergaard M,Skovbakke SL,Schneider CL,Lauridsen F,Andresen L,Jensen H,Skov S
Published figure using CD28 monoclonal antibody (Product # 14-0289-82) in T-Cell Activation
Fri Jul 18 00:00:00 EDT 2014
Detailed characterization of tumor infiltrating lymphocytes in two distinct human solid malignancies show phenotypic similarities.
Journal for immunotherapy of cancer
Kovacsovics-Bankowski M,Chisholm L,Vercellini J,Tucker CG,Montler R,Haley D,Newell P,Ma J,Tseng P,Wolf R,Vetto JT,Hammill C,Hansen P,Weinberg AD
Published figure using CD28 monoclonal antibody (Product # 14-0289-82) in Flow Cytometry
Mon Dec 01 00:00:00 EST 2014
T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production.
Blood
Riches JC,Davies JK,McClanahan F,Fatah R,Iqbal S,Agrawal S,Ramsay AG,Gribben JG
14-0289 was used in Functional assays to demonstrate that although CLL CD8+ T-cells exhibit features of T-cell exhaustion, they retain the ability to produce cytokines.
Thu Feb 28 00:00:00 EST 2013
Soluble GARP has potent antiinflammatory and immunomodulatory impact on human CD4⁺ T cells.
Blood
Hahn SA,Stahl HF,Becker C,Correll A,Schneider FJ,Tuettenberg A,Jonuleit H
14-0289 was used in Functional assays to analyse the impact of a soluble glycoprotein A repetitions predominant (GARP) protein on human CD4+ T cell differentiation and activation.
Thu Aug 15 00:00:00 EDT 2013
B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms.
Journal of autoimmunity
Podojil JR,Liu LN,Marshall SA,Chiang MY,Goings GE,Chen L,Langermann S,Miller SD
14-0289 was used in Functional assays to investigate the inhibition of mouse and human T-cell function and treatment of EAE via IL-10/Treg-dependent mechanisms through B7-H4Ig.
Thu Aug 01 00:00:00 EDT 2013
Activation of the transcriptional function of the NF-κB protein c-Rel by O-GlcNAc glycosylation.
Science signaling
Ramakrishnan P,Clark PM,Mason DE,Peters EC,Hsieh-Wilson LC,Baltimore D
14-0289 was used in Functional assays to investigate the role of O-GlcNAcylation on NF-κB activity, showing that c-Rel is activated.
Tue Aug 27 00:00:00 EDT 2013
Methylation of FOXP3 in regulatory T cells is related to the severity of coronary artery disease.
Atherosclerosis
Jia L,Zhu L,Wang JZ,Wang XJ,Chen JZ,Song L,Wu YJ,Sun K,Yuan ZY,Hui R
14-0289 was used in Flow cytometry/Cell sorting to demonstrate that reduction in regulatory T-cells is associated with acute coronary syndrome in atherosclerotic patients.
Sat Jun 01 00:00:00 EDT 2013
Mesenchymal stem cells from periapical lesions modulate differentiation and functional properties of monocyte-derived dendritic cells.
European journal of immunology
Dokić J,Tomić S,Marković M,Milosavljević P,Colić M
Mon Jul 01 00:00:00 EDT 2013
Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR is required for initiation of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Chen J,Cascio J,Magee JD,Techasintana P,Gubin MM,Dahm GM,Calaluce R,Yu S,Atasoy U
14-0289 was used in Flow cytometry/Cell sorting to reveal a HuR-induced posttranscriptional regulatory mechanism of Th17 cell differentiation that influences IL-17 expression and autoimmune neuroinflammation.
Sun Dec 01 00:00:00 EST 2013
Fine-tuning of regulatory T cell function: the role of calcium signals and naive regulatory T cells for regulatory T cell deficiency in multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950)
Schwarz A,Schumacher M,Pfaff D,Schumacher K,Jarius S,Balint B,Wiendl H,Haas J,Wildemann B
14-0289 was used in Functional assays to investigate the mechanisms underlying impaired suppressor functions in Tregs in multiple sclerosis, showing that calcium signals and naive regulatory T cells play a role.
Wed May 15 00:00:00 EDT 2013
Nuclear translocation of MEK1 triggers a complex T cell response through the corepressor silencing mediator of retinoid and thyroid hormone receptor.
Journal of immunology (Baltimore, Md. : 1950)
Guo L,Chen C,Liang Q,Karim MZ,Gorska MM,Alam R
14-0289 was used in Functional assays to show that MEK1 translocates to the nucleus following TCR stimulation and interacts with the nuclear co-repressor SMRT in CD4 T cells.
Tue Jan 01 00:00:00 EST 2013
Human neonatal naive CD4+ T cells have enhanced activation-dependent signaling regulated by the microRNA miR-181a.
Journal of immunology (Baltimore, Md. : 1950)
Palin AC,Ramachandran V,Acharya S,Lewis DB
14-0289 was used in Functional assays to investigate the developmental differences in immune function between human neonates and adults, showing that neonatal naive CD4+ T cells have enhanced activation-dependent signalling.
Fri Mar 15 00:00:00 EDT 2013
LAT1 is a critical transporter of essential amino acids for immune reactions in activated human T cells.
Journal of immunology (Baltimore, Md. : 1950)
Hayashi K,Jutabha P,Endou H,Sagara H,Anzai N
14-0289-82 was used in Western Blotting to uncover the previously unknown mechanism by which T cells accelerate essential amino acid uptake upon activation and adapt to essential amino acid starvation.
Tue Oct 15 00:00:00 EDT 2013
Intercellular adhesion molecule 1 mediates migration of Th1 and Th17 cells across human retinal vascular endothelium.
Investigative ophthalmology & visual science
Bharadwaj AS,Schewitz-Bowers LP,Wei L,Lee RW,Smith JR
14-0289 was used in Flow cytometry/Cell sorting to investigate the ability of human Th1- and Th17-polarised cells to cross a simulated human retinal endothelium, and examined the role of IgG superfamily members in this process.
Wed Oct 23 00:00:00 EDT 2013
Anti-KIT designer T cells for the treatment of gastrointestinal stromal tumor.
Journal of translational medicine
Katz SC,Burga RA,Naheed S,Licata LA,Thorn M,Osgood D,Nguyen CT,Espat NJ,Fletcher JA,Junghans RP
14-0289 was used in Flow cytometry/Cell sorting to develop a novel anti-KIT chimeric immune receptor to target KIT+ gastrointestinal stromal tumours using designer T cells.
Thu Feb 21 00:00:00 EST 2013
Protection against H5N1 highly pathogenic avian and pandemic (H1N1) 2009 influenza virus infection in cynomolgus monkeys by an inactivated H5N1 whole particle vaccine.
PloS one
Nakayama M,Shichinohe S,Itoh Y,Ishigaki H,Kitano M,Arikata M,Pham VL,Ishida H,Kitagawa N,Okamatsu M,Sakoda Y,Ichikawa T,Tsuchiya H,Nakamura S,Le QM,Ito M,Kawaoka Y,Kida H,Ogasawara K
14-0289 was used in Flow cytometry/Cell sorting to examine the efficacy of the H5N1 vaccine candidate Vac-3 against two clades of H5N1 HPAIV strains in cynomolgus macaques.
Tue Mar 03 00:00:00 EST 2015
Antibody-mediated targeting of the Orai1 calcium channel inhibits T cell function.
PloS one
Cox JH,Hussell S,Søndergaard H,Roepstorff K,Bui JV,Deer JR,Zhang J,Li ZG,Lamberth K,Kvist PH,Padkjær S,Haase C,Zahn S,Odegard VH
14-0289 was used in Functional assays to investigate the use of ion channels as therapeutic targets for the treatment of autoimmunity and other diseases.
Mon Oct 06 00:00:00 EDT 2014
Mycobacterial phosphatidylinositol mannoside 6 (PIM6) up-regulates TCR-triggered HIV-1 replication in CD4+ T cells.
PloS one
Rodriguez ME,Loyd CM,Ding X,Karim AF,McDonald DJ,Canaday DH,Rojas RE
14-0289 was used in Functional assays to study the direct effects of different MTB molecules on HIV-1 replication in T cells.
Tue Aug 05 00:00:00 EDT 2014
Incomplete normalization of regulatory t-cell frequency in the gut mucosa of Colombian HIV-infected patients receiving long-term antiretroviral treatment.
PloS one
Rueda CM,Velilla PA,Chougnet CA,Rugeles MT
14-0289 was used in Functional assays to assess the frequency and phenotype of regulatory T-cells within CMV and HIV patients on different treatment regimes.
Tue Sep 23 00:00:00 EDT 2014
A quantitative assessment of costimulation and phosphatase activity on microclusters in early T cell signaling.
PloS one
Witsenburg JJ,Glauner H,Müller JP,Groenewoud JM,Roth G,Böhmer FD,Adjobo-Hermans MJ,Brock R
14-0289 was used in a Functional assay to describe an accessible procedure for the quantitative analysis of stimulus-dependent protein microcluster formation in early T cell signalling.
Sat Feb 21 00:00:00 EST 2015
LINE-1 retrotransposable element DNA accumulates in HIV-1-infected cells.
Journal of virology
Jones RB,Song H,Xu Y,Garrison KE,Buzdin AA,Anwar N,Hunter DV,Mujib S,Mihajlovic V,Martin E,Lee E,Kuciak M,Raposo RA,Bozorgzad A,Meiklejohn DA,Ndhlovu LC,Nixon DF,Ostrowski MA
14-0289 was used in Functional assays to investigate whether HIV-1 infection compromises cellular control of L1 elements, showing that LINE-1 retrotransposable element DNA accumulates in infected cells.
Sun Dec 01 00:00:00 EST 2013
Oligodeoxynucleotides stabilize Helios-expressing Foxp3+ human T regulatory cells during in vitro expansion.
Blood
Kim YC,Bhairavabhotla R,Yoon J,Golding A,Thornton AM,Tran DQ,Shevach EM
14-0289 was used in Flow cytometry/Cell sorting to show that addition of a 25-mer oligonucleotide during Foxp3(+) Treg expansion yields an optimal population for use in cellular biotherapy.
Thu Mar 22 00:00:00 EDT 2012
Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection.
The Journal of experimental medicine
Wang C,McPherson AJ,Jones RB,Kawamura KS,Lin GH,Lang PA,Ambagala T,Pellegrini M,Calzascia T,Aidarus N,Elford AR,Yue FY,Kremmer E,Kovacs CM,Benko E,Tremblay C,Routy JP,Bernard NF,Ostrowski MA,Ohashi PS,Watts TH
14-0289 was used in Functional assays to study the role of TRAF1 on the responses of CD8 T cells to chronic HIV infection.
Mon Jan 16 00:00:00 EST 2012
A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells.
Autophagy
Phadwal K,Alegre-Abarrategui J,Watson AS,Pike L,Anbalagan S,Hammond EM,Wade-Martins R,McMichael A,Klenerman P,Simon AK
Published figure using CD28 monoclonal antibody (Product # 14-0289-82) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2012
K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation.
Journal of leukocyte biology
Wang T,Huang C,Lopez-Coral A,Slentz-Kesler KA,Xiao M,Wherry EJ,Kaufman RE
14-0289 was used in Functional assays to study the ability of SECTM1 to stimulate CD27-dependent T cell proliferation and production of INF-gamma.
Thu Mar 01 00:00:00 EST 2012
K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation.
Journal of leukocyte biology
Wang T,Huang C,Lopez-Coral A,Slentz-Kesler KA,Xiao M,Wherry EJ,Kaufman RE
14-0289 was used in Functional assays to study the ability of SECTM1 to stimulate CD27-dependent T cell proliferation and production of INF-gamma.
Thu Mar 01 00:00:00 EST 2012
Antigen-independent induction of Tim-3 expression on human T cells by the common γ-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway.
Journal of immunology (Baltimore, Md. : 1950)
Mujib S,Jones RB,Lo C,Aidarus N,Clayton K,Sakhdari A,Benko E,Kovacs C,Ostrowski MA
14-0289 was used in Flow cytometry/Cell sorting to show that Tim-3 can be induced via TCR/CD28 costimulation and/or γc cytokines, likely through the PI3K pathway.
Sun Apr 15 00:00:00 EDT 2012
Do plant cyclotides have potential as immunosuppressant peptides?
Journal of natural products
Gründemann C,Koehbach J,Huber R,Gruber CW
14-0289 was used in Functional assays to analyse crude plant extract and observe the antiproliferative effect of a contained cyclotide, kalata B1, on immune cells.
Fri Feb 24 00:00:00 EST 2012
Memory immune responses against pandemic (H1N1) 2009 influenza virus induced by a whole particle vaccine in cynomolgus monkeys carrying Mafa-A1*052:02.
PloS one
Arikata M,Itoh Y,Okamatsu M,Maeda T,Shiina T,Tanaka K,Suzuki S,Nakayama M,Sakoda Y,Ishigaki H,Takada A,Ishida H,Soda K,Pham VL,Tsuchiya H,Nakamura S,Torii R,Shimizu T,Inoko H,Ohkubo I,Kida H,Ogasawara K
14-0289 was used in Functional assays to examine the effectiveness of a vaccine derived from a virus library for pandemic virus infection in immunologically naïve macaques.
Wed Sep 19 00:00:00 EDT 2012
Cannabinoid receptor 2-mediated attenuation of CXCR4-tropic HIV infection in primary CD4+ T cells.
PloS one
Costantino CM,Gupta A,Yewdall AW,Dale BM,Devi LA,Chen BK
14-0289 was used in Functional assays to investigate whether drugs targeting cannabinoid receptors modulate chemokine co-receptor function and regulate HIV-1 infectivity.
Mon Aug 20 00:00:00 EDT 2012
Follicular lymphoma tumor-infiltrating T-helper (T(H)) cells have the same polyfunctional potential as normal nodal T(H) cells despite skewed differentiation.
Blood
Hilchey SP,Rosenberg AF,Hyrien O,Secor-Socha S,Cochran MR,Brady MT,Wang JC,Sanz I,Burack WR,Quataert SA,Bernstein SH
14-0289 was used in Functional assays to evaluate the potential of FL-infiltrating CD4(+) T-helper cells to elicit antitumour effects.
Thu Sep 29 00:00:00 EDT 2011
Significant mobilization of both conventional and regulatory T cells with AMD3100.
Blood
Kean LS,Sen S,Onabajo O,Singh K,Robertson J,Stempora L,Bonifacino AC,Metzger ME,Promislow DE,Mattapallil JJ,Donahue RE
14-0289 was used in Flow cytometry/Cell sorting to indicate that AMD3100 may mobilize a GVHD-protective T-cell repertoire.
Thu Dec 15 00:00:00 EST 2011
Heat shock protein 27 differentiates tolerogenic macrophages that may support human breast cancer progression.
Cancer research
Banerjee S,Lin CF,Skinner KA,Schiffhauer LM,Peacock J,Hicks DG,Redmond EM,Morrow D,Huston A,Shayne M,Langstein HN,Miller-Graziano CL,Strickland J,O'Donoghue L,De AK
14-0289 was used in Functional assays to investigate the role of Hsp27 in breast cancer, showing that Hsp27 differentiates tolerogenic macrophages.
Sat Jan 15 00:00:00 EST 2011
Impairment of regulatory capacity of CD4+CD25+ regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves' disease.
Journal of immunology (Baltimore, Md. : 1950)
Mao C,Wang S,Xiao Y,Xu J,Jiang Q,Jin M,Jiang X,Guo H,Ning G,Zhang Y
14-0289 was used in Functional assays to investigate whether dendritic cells are the main cause of defective regulatory T cell activity in Graves' disease patients.
Fri Apr 15 00:00:00 EDT 2011
Cross-talk between TCR and CCR7 signaling sets a temporal threshold for enhanced T lymphocyte migration.
Journal of immunology (Baltimore, Md. : 1950)
Schaeuble K,Hauser MA,Singer E,Groettrup M,Legler DF
14-0289 was used in in vitro experiments to characterize cross-talk between TCR and CCR7 and provide evidence that the activation status of T cells controls lymphocyte motility.
Thu Dec 01 00:00:00 EST 2011
Costimulation through the CD137/4-1BB pathway protects human melanoma tumor-infiltrating lymphocytes from activation-induced cell death and enhances antitumor effector function.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Hernandez-Chacon JA,Li Y,Wu RC,Bernatchez C,Wang Y,Weber JS,Hwu P,Radvanyi LG
14-0289-82 was used in Functional assay to indicate that 4-1BB costimulation may significantly improve tumor-infiltrating lymphocyte survival during melanoma adoptive T-cell therapy and boost antitumor cytolytic activity.
Fri Apr 01 00:00:00 EDT 2011
Effect of chromium and cobalt ions on primary human lymphocytes in vitro.
Journal of immunotoxicology
Akbar M,Brewer JM,Grant MH
14-0289 was used in Functional assays to investigate the effects of clinically relevant concentrations of Cr(6+) and Co(2+) on primary human lymphocytes.
Wed Jun 01 00:00:00 EDT 2011
Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes.
The Journal of biological chemistry
López-Huertas MR,Mateos E,Díaz-Gil G,Gómez-Esquer F,Sánchez del Cojo M,Alcamí J,Coiras M
14-0289 was used in Functional assays to analyse the effect of Rottlerin, a dose-dependent PKC inhibitor, on HIV-1 replication in T cells.
Fri Aug 05 00:00:00 EDT 2011
Differential expression of CD300a/c on human TH1 and TH17 cells.
BMC immunology
Simhadri VR,Mariano JL,Zhou Q,DeBell KE,Borrego F
14-0289 was used in Flow cytometry/Cell sorting to conclude that the CD300a/c receptors are differentially expressed on human TH1 and TH17 cells, and that their ligation is capable of modulating TCR mediated signals.
Wed Nov 02 00:00:00 EDT 2011
Thymic stromal lymphopoietin from trophoblasts induces dendritic cell-mediated regulatory TH2 bias in the decidua during early gestation in humans.
Blood
Guo PF,Du MR,Wu HX,Lin Y,Jin LP,Li DJ
14-0289 was used in Functional assays to demonstrate that human trophoblasts may contribute to maternal-fetal tolerance by instructing dDCs to induce regulatory TH2 bias in human early pregnancy via TSLP.
Thu Sep 23 00:00:00 EDT 2010
Accumulation of foxp3+ T regulatory cells in draining lymph nodes correlates with disease progression and immune suppression in colorectal cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research
Deng L,Zhang H,Luan Y,Zhang J,Xing Q,Dong S,Wu X,Liu M,Wang S
14-0289 was used in Functional assays to reveal the association between the frequency of Tregs in tumour draining lymph nodes and cancer progression.
Sun Aug 15 00:00:00 EDT 2010
Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America
Colombo SL,Palacios-Callender M,Frakich N,De Leon J,Schmitt CA,Boorn L,Davis N,Moncada S
14-0289 was used in Functional assays to explore how the anaphase-promoting complex/cyclosome-Cdh1 controls the proliferative response of human T lymphocytes.
Tue Nov 02 00:00:00 EDT 2010
Fas ligand gene expression is directly regulated by stress-inducible heat shock transcription factor-1.
Cell death and differentiation
Bouchier-Hayes L,McBride S,van Geelen CM,Nance S,Lewis LK,Pinkoski MJ,Beere HM
14-0289 was used in Flow cytometry/Cell sorting to demonstrate the ability of HSF-1 to mediate stress-inducible expression of FasL.
Tue Jun 01 00:00:00 EDT 2010
An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Larsen CP,Page A,Linzie KH,Russell M,Deane T,Stempora L,Strobert E,Penedo MC,Ward T,Wiseman R,O'Connor D,Miller W,Sen S,Singh K,Kean LS
14-0289 was used in Flow cytometry/Cell sorting to study mixed hematopoietic chimerism and immune tolerance in a novel MHC-defined rhesus macaque model.
Mon Nov 01 00:00:00 EDT 2010
A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells.
Molecular immunology
Getnet D,Grosso JF,Goldberg MV,Harris TJ,Yen HR,Bruno TC,Durham NM,Hipkiss EL,Pyle KJ,Wada S,Pan F,Pardoll DM,Drake CG
14-0289 was used in Functional assays to investigate possible reasons for the observed upregulation of Helios in regulatory T cells.
Thu Apr 01 00:00:00 EDT 2010
Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin.
PloS one
Narayanan S,Silva R,Peruzzi G,Alvarez Y,Simhadri VR,Debell K,Coligan JE,Borrego F
14-0289 was used in Functional assays to investigate a subset within the CD4 T cell population defined by expression of the immunomodulatory receptor CD300a.
Thu May 13 00:00:00 EDT 2010
HCV+ hepatocytes induce human regulatory CD4+ T cells through the production of TGF-beta.
PloS one
Hall CH,Kassel R,Tacke RS,Hahn YS
14-0289 was used in Functional assays to determine whether Hepatitis C virus-infected hepatocytes are capable of inducing regulatory T cells.
Fri Aug 13 00:00:00 EDT 2010
Novel role of plasmacytoid dendritic cells in humans: induction of interleukin-10-producing Treg cells by plasmacytoid dendritic cells in patients with rheumatoid arthritis responding to therapy.
Arthritis and rheumatism
Kavousanaki M,Makrigiannakis A,Boumpas D,Verginis P
14-0289 was used in Functional assays to explore the contribution of dendritic cells to the development of regulatory T cells in a human autoimmune disease setting.
Fri Jan 01 00:00:00 EST 2010
Loss of the Brm-type SWI/SNF chromatin remodeling complex is a strong barrier to the Tat-independent transcriptional elongation of human immunodeficiency virus type 1 transcripts.
Journal of virology
Mizutani T,Ishizaka A,Tomizawa M,Okazaki T,Yamamichi N,Kawana-Tachikawa A,Iwamoto A,Iba H
14-0289 was used in Functional assays to elucidate the epigenetic regulation of Tat-independent HIV transcription following proviral integration, showing that loss of the Brm-type SWI/SNF chromatin remodeling complex is a strong barrier against elongation.
Sun Nov 01 00:00:00 EDT 2009
Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression.
Journal of immunology (Baltimore, Md. : 1950)
Lin JT,Lineberry NB,Kattah MG,Su LL,Utz PJ,Fathman CG,Wu L
14-0289 was used in Functional assays to investigate the role of GRAIL in CD4 T cells, showing that proliferation is controlled by mTOR regulation of GRAIL expression.
Fri May 15 00:00:00 EDT 2009
CD69 gene is differentially regulated in T and B cells by evolutionarily conserved promoter-distal elements.
Journal of immunology (Baltimore, Md. : 1950)
Vazquez BN,Laguna T,Carabana J,Krangel MS,Lauzurica P
14-0289 was used in Functional assays to investigate the molecular mechanism underlying mouse CD69 gene transcription in vivo in T and B cells, showing it is is differentially regulated.
Sun Nov 15 00:00:00 EST 2009
Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras.
FEBS letters
Malik NM,Gilroy DW,Kabouridis PS
14-0289-82 was used in Immunoprecipitation to develop cell-penetrating Ras inhibitors and study their ability to inhibit T-cell activation, showing that anti-CD3/CD28-activated cells had a reduction in cell size, proliferation and increased apoptosis.
Mon Jan 05 00:00:00 EST 2009
Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras.
FEBS letters
Malik NM,Gilroy DW,Kabouridis PS
14-0289-82 was used in Immunoprecipitation to develop cell-penetrating Ras inhibitors and study their ability to inhibit T-cell activation, showing that anti-CD3/CD28-activated cells had a reduction in cell size, proliferation and increased apoptosis.
Mon Jan 05 00:00:00 EST 2009
Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras.
FEBS letters
Malik NM,Gilroy DW,Kabouridis PS
14-0289-82 was used in Immunoprecipitation to develop cell-penetrating Ras inhibitors and study their ability to inhibit T-cell activation, showing that anti-CD3/CD28-activated cells had a reduction in cell size, proliferation and increased apoptosis.
Mon Jan 05 00:00:00 EST 2009
Interaction of human PD-L1 and B7-1.
Molecular immunology
Butte MJ,Peña-Cruz V,Kim MJ,Freeman GJ,Sharpe AH
14-0289 was used in Flow cytometry/Cell sorting to investigate whether human B7-1 and PD-L1 can participate in a similar interaction as murine B7-1 and PD-L1 do, showing that there is interaction of human PD-L1 and B7-1.
Fri Aug 01 00:00:00 EDT 2008
CD3+CD4low and CD3+CD8low are induced by HLA-G: novel human peripheral blood suppressor T-cell subsets involved in transplant acceptance.
Blood
Naji A,Le Rond S,Durrbach A,Krawice-Radanne I,Creput C,Daouya M,Caumartin J,LeMaoult J,Carosella ED,Rouas-Freiss N
14-0289-82 was used in Functional assay to define novel immunosuppressive subpopulations of peripheral blood T cells induced by HLA-G with potent implications in peripheral tolerance.
Sat Dec 01 00:00:00 EST 2007
A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.
The Journal of experimental medicine
Di Bartolo V,Montagne B,Salek M,Jungwirth B,Carrette F,Fourtane J,Sol-Foulon N,Michel F,Schwartz O,Lehmann WD,Acuto O
14-0289 was used in Functional assays to identify 14-3-3epsilon and zeta proteins as SLP-76 binding partners.
Mon Mar 19 00:00:00 EDT 2007
Many NK cell receptors activate ERK2 and JNK1 to trigger microtubule organizing center and granule polarization and cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America
Chen X,Trivedi PP,Ge B,Krzewski K,Strominger JL
14-0289-82 was used in Immunocytochemistry to elucidate the signalling pathways responsible for natural killer cell cytotoxicity.
Tue Apr 10 00:00:00 EDT 2007
Many NK cell receptors activate ERK2 and JNK1 to trigger microtubule organizing center and granule polarization and cytotoxicity.
Proceedings of the National Academy of Sciences of the United States of America
Chen X,Trivedi PP,Ge B,Krzewski K,Strominger JL
14-0289-82 was used in Immunocytochemistry to elucidate the signalling pathways responsible for natural killer cell cytotoxicity.
Tue Apr 10 00:00:00 EDT 2007
Phosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-kappaB activation.
Molecular and cellular biology
Zeng H,Di L,Fu G,Chen Y,Gao X,Xu L,Lin X,Wen R
Published figure using CD28 monoclonal antibody (Product # 14-0289-82) in T-Cell Activation
Sun Jul 01 00:00:00 EDT 2007
Bacterial superantigens bypass Lck-dependent T cell receptor signaling by activating a Galpha11-dependent, PLC-beta-mediated pathway.
Immunity
Bueno C,Lemke CD,Criado G,Baroja ML,Ferguson SS,Rahman AK,Tsoukas CD,McCormick JK,Madrenas J
14-0289 was used in Functional assays to show that this alternative pathway operates in the absence of Lck-dependent tyrosine-phosphorylation events and was initiated by the TCR-dependent activation of raft-enriched heterotrimeric Galpha11 proteins.
Sat Jul 01 00:00:00 EDT 2006
CD28-stimulated ERK2 phosphorylation is required for polarization of the microtubule organizing center and granules in YTS NK cells.
Proceedings of the National Academy of Sciences of the United States of America
Chen X,Allan DSJ,Krzewski K,Ge B,Kopcow H,Strominger JL
14-0289 was used in Flow cytometry/Cell sorting to show CD28 to be an activating receptor necessary for the activation of natural killer cell cytotoxicity.
Wed Jul 05 00:00:00 EDT 2006
CD1d-unrestricted human NKT cells release chemokines upon Fas engagement.
Blood
Giroux M,Denis F
14-0289 was used in Flow cytometry/Cell sorting to investigate whether the Fas ligand was directly or indirectly chemotactic toward neutrophils, showing that CD1d-unrestricted human NKT cells release chemokines upon Fas engagement.
Sat Jan 15 00:00:00 EST 2005
Interleukin-15 increases effector memory CD8+ t cells and NK Cells in simian immunodeficiency virus-infected macaques.
Journal of virology
Mueller YM,Petrovas C,Bojczuk PM,Dimitriou ID,Beer B,Silvera P,Villinger F,Cairns JS,Gracely EJ,Lewis MG,Katsikis PD
14-0289 was used in an ELISpot assay to investigate the in vivo effect of IL-15 treatment in nine SIVmac251-infected cynomolgus macaques.
Fri Apr 01 00:00:00 EST 2005
Interleukin-15 increases effector memory CD8+ t cells and NK Cells in simian immunodeficiency virus-infected macaques.
Journal of virology
Mueller YM,Petrovas C,Bojczuk PM,Dimitriou ID,Beer B,Silvera P,Villinger F,Cairns JS,Gracely EJ,Lewis MG,Katsikis PD
14-0289 was used in an ELISpot assay to investigate the in vivo effect of IL-15 treatment in nine SIVmac251-infected cynomolgus macaques.
Fri Apr 01 00:00:00 EST 2005
