Invitrogen

CD62L (L-Selectin) Monoclonal Antibody (MEL-14), PE-Cyanine5, eBioscience™

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Antibody Testing Data (1)
Published Figures (63)

CD62L (L-Selectin) Antibody in Flow Cytometry (Flow)

FIGURE: 1 / 64

CD62L (L-Selectin) Antibody (15-0621-82) in Flow

Staining of BALB/c splenocytes with Anti-Mouse CD3e FITC (Product # 11-0031-82) and 0.06 µg of Rat IgG2a K Isotype Control PE-Cyanine5 (Product # 15-4321-80) (left) or 0.06 µg of Anti-Mouse CD62L (L-Selectin) PE-Cyanine5 (right).Total viable cells were used for analysis.

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Product Details

15-0621-82

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

0.125 µg/test

View 53 publications 53 publications

Product Specifications

Species Reactivity

Mouse

Published species

Mouse

Host/Isotype

Rat / IgG2a, kappa

Recommended Isotype Control

Rat IgG2a kappa Isotype Control (eBR2a), PE-Cyanine5, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

MEL-14

Conjugate

PE-Cyanine5 PE-Cyanine5 PE-Cyanine5

Excitation/Emission Max

568/666 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_468767

Product Specific Information

Description: The MEL-14 monoclonal antibody reacts with mouse CD62L, a 76 kDa member of the selectin family. CD62L is expressed by neutrophils, monocytes, and subsets of T, B, and NK cells and binds a number of glycosylated, fucosylated, sulfated sialylated glycoproteins including CD34, glycam-1 and MAdCam-1. These interactions mediate rolling of lymphocytes on activated endothelium at the sites of inflammation and homing of cells to the high endothelial venules (HEV) of peripheral lymphoid tissues.

Applications Reported: The MEL-14 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The MEL-14 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Light sensitivity: This tandem dye is sensitive photo-induced oxidation. Please protect this vial and stained samples from light.

Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-822-49) (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product # 00-5333-54) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.

Excitation: 488-561 nm; Emission: 667 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

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Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression.

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Qi M,Xia Y,Wu Y,Zhang Z,Wang X,Lu L,Dai C,Song Y,Xu K,Ji W,Zhan L

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

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Amphiphile-CpG vaccination induces potent lymph node activation and COVID-19 immunity in mice and non-human primates.

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Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Fri Oct 28 00:00:00 EDT 2022

Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccination.

EMBO molecular medicine

Müller K,Gibbins MP,Roberts M,Reyes-Sandoval A,Hill AVS,Draper SJ,Matuschewski K,Silvie O,Hafalla JCR

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Fri Apr 09 00:00:00 EDT 2021

Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance.

Frontiers in cell and developmental biology

Zhang Q,Liang Z,Zhang J,Lei T,Dong X,Su H,Chen Y,Zhang Z,Tan L,Zhao Y

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Wed Apr 21 00:00:00 EDT 2021

Trichinella spiralis Paramyosin Induces Colonic Regulatory T Cells to Mitigate Inflammatory Bowel Disease.

Frontiers in cell and developmental biology

Hao C,Wang W,Zhan B,Wang Z,Huang J,Sun X,Zhu X

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Tue Aug 03 00:00:00 EDT 2021

CD8⁺ T cells in the central nervous system of mice with herpes simplex infection are highly activated and express high levels of CCR5 and CXCR3.

Journal of neurovirology

Lind L,Svensson A,Thörn K,Krzyzowska M,Eriksson K

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

cDC1 Dependent Accumulation of Memory T Cells Is Required for Chronic Autoimmune Inflammation in Murine Testis.

Frontiers in immunology

Jing Y,Cao M,Zhang B,Long X,Wang X

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Fri Sep 24 00:00:00 EDT 2021

Evaluation of DNA-Launched Virus-Like Particle Vaccines in an Immune Competent Mouse Model of Chikungunya Virus Infection.

Vaccines

Rayner JO,Kim JH,Roberts RW,Wood RR,Fouty B,Solodushko V

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Fri Apr 02 00:00:00 EDT 2021

PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8⁺ T cells at the expense of central memory.

Cell reports

Cannons JL,Villarino AV,Kapnick SM,Preite S,Shih HY,Gomez-Rodriguez J,Kaul Z,Shibata H,Reilley JM,Huang B,Handon R,McBain IT,Gossa S,Wu T,Su HC,McGavern DB,O'Shea JJ,McGuire PJ,Uzel G,Schwartzberg PL

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Tue Oct 12 00:00:00 EDT 2021

Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression.

iScience

AbuEid M,McAllister DM,McOlash L,Harwig MC,Cheng G,Drouillard D,Boyle KA,Hardy M,Zielonka J,Johnson BD,Hill RB,Kalyanaraman B,Dwinell MB

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Fri Jun 25 00:00:00 EDT 2021

Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis.

Nature communications

Li H,Wang M,Huang B,Zhu SW,Zhou JJ,Chen DR,Cui R,Zhang M,Sun ZJ

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Thu Dec 09 00:00:00 EST 2021

Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.

Cell reports

Budhu S,Giese R,Gupta A,Fitzgerald K,Zappasodi R,Schad S,Hirschhorn D,Campesato LF,De Henau O,Gigoux M,Liu C,Mazo G,Deng L,Barker CA,Wolchok JD,Merghoub T

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Type 1 Cytotoxic T Cells Increase in Placenta after Intrauterine Inflammation.

Frontiers in immunology

Liu J,Liu Y,Panda S,Liu A,Lei J,Burd I

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Fri Dec 17 00:00:00 EST 2021

Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.

EBioMedicine

Okada R,Furusawa A,Vermeer DW,Inagaki F,Wakiyama H,Kato T,Nagaya T,Choyke PL,Spanos WC,Allen CT,Kobayashi H

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy.

Journal of neuroinflammation

Oladiran O,Shi XQ,Yang M,Fournier S,Zhang J

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Mon Mar 22 00:00:00 EDT 2021

STING Activated Tumor-Intrinsic Type I Interferon Signaling Promotes CXCR3 Dependent Antitumor Immunity in Pancreatic Cancer.

Cellular and molecular gastroenterology and hepatology

Vonderhaar EP,Barnekow NS,McAllister D,McOlash L,Eid MA,Riese MJ,Tarakanova VL,Johnson BD,Dwinell MB

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Mon Jan 24 00:00:00 EST 2022

A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.

Nature communications

Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.

Frontiers in immunology

Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Tue Jan 11 00:00:00 EST 2022

Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.

STAR protocols

Skordos I,Demeyer A,Beyaert R

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Fri Mar 19 00:00:00 EDT 2021

B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches.

Cell reports

Biram A,Winter E,Denton AE,Zaretsky I,Dassa B,Bemark M,Linterman MA,Yaari G,Shulman Z

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Tue Feb 11 00:00:00 EST 2020

Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.

Nature communications

Sidwell T,Liao Y,Garnham AL,Vasanthakumar A,Gloury R,Blume J,Teh PP,Chisanga D,Thelemann C,de Labastida Rivera F,Engwerda CR,Corcoran L,Kometani K,Kurosaki T,Smyth GK,Shi W,Kallies A

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Tue Jan 14 00:00:00 EST 2020

Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease.

Cell reports

Nguyen HD,Ticer T,Bastian D,Kuril S,Li H,Du H,Yan C,Yu XZ

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Neurokinin-1 Receptor Signaling Is Required for Efficient Ca²⁺ Flux in T-Cell-Receptor-Activated T Cells.

Cell reports

Morelli AE,Sumpter TL,Rojas-Canales DM,Bandyopadhyay M,Chen Z,Tkacheva O,Shufesky WJ,Wallace CT,Watkins SC,Berger A,Paige CJ,Falo LD,Larregina AT

15-0621 was used in Flow cytometry/Cell sorting to demonstrate an effect of the NK1R in T cells that is relevant for immunotherapies based on pro-inflammatory neuropeptides and its receptors.

Tue Mar 10 00:00:00 EDT 2020

Localized cocktail chemoimmunotherapy after in situ gelation to trigger robust systemic antitumor immune responses.

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Chao Y,Liang C,Tao H,Du Y,Wu D,Dong Z,Jin Q,Chen G,Xu J,Xiao Z,Chen Q,Wang C,Chen J,Liu Z

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2020

ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.

Nature communications

Cao Y,Trillo-Tinoco J,Sierra RA,Anadon C,Dai W,Mohamed E,Cen L,Costich TL,Magliocco A,Marchion D,Klar R,Michel S,Jaschinski F,Reich RR,Mehrotra S,Cubillos-Ruiz JR,Munn DH,Conejo-Garcia JR,Rodriguez PC

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Wed Mar 20 00:00:00 EDT 2019

Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer.

Cell reports

Choi H,Deng J,Li S,Silk T,Dong L,Brea EJ,Houghton S,Redmond D,Zhong H,Boiarsky J,Akbay EA,Smith PD,Merghoub T,Wong KK,Wolchok JD

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

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Activated Peyer's patch B cells sample antigen directly from M cells in the subepithelial dome.

Nature communications

Komban RJ,Strömberg A,Biram A,Cervin J,Lebrero-Fernández C,Mabbott N,Yrlid U,Shulman Z,Bemark M,Lycke N

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

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MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance.

Autophagy

Liang Z,Zhang L,Su H,Luan R,Na N,Sun L,Zhao Y,Zhang X,Zhang Q,Li J,Zhang L,Zhao Y

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Fri Mar 22 00:00:00 EDT 2019

Prophylactic vs. Therapeutic Treatment With P2Et Polyphenol-Rich Extract Has Opposite Effects on Tumor Growth.

Frontiers in oncology

Lasso P,Gomez-Cadena A,Urueña C,Donda A,Martinez-Usatorre A,Barreto A,Romero P,Fiorentino S

15-0621 was used in Flow cytometry/Cell sorting to evaluate the ability of P2Et extract to modulate the immune system in both steady state and tumour challenge.

Thu Oct 01 00:00:00 EDT 2020

C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans.

JCI insight

Verghese DA,Chun N,Paz K,Fribourg M,Woodruff TM,Flynn R,Hu Y,Xiong H,Zhang W,Yi Z,Du J,Blazar BR,Heeger PS

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Thu Dec 20 00:00:00 EST 2018

Helminth-induced IL-4 expands bystander memory CD8⁺ T cells for early control of viral infection.

Nature communications

Rolot M,Dougall AM,Chetty A,Javaux J,Chen T,Xiao X,Machiels B,Selkirk ME,Maizels RM,Hokke C,Denis O,Brombacher F,Vanderplasschen A,Gillet L,Horsnell WGC,Dewals BG

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Tue Oct 30 00:00:00 EDT 2018

Stability and function of regulatory T cells expressing the transcription factor T-bet.

Nature

Levine AG,Mendoza A,Hemmers S,Moltedo B,Niec RE,Schizas M,Hoyos BE,Putintseva EV,Chaudhry A,Dikiy S,Fujisawa S,Chudakov DM,Treuting PM,Rudensky AY

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Thu Jun 15 00:00:00 EDT 2017

Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.

Cancer cell

Turaj AH,Hussain K,Cox KL,Rose-Zerilli MJJ,Testa J,Dahal LN,Chan HTC,James S,Field VL,Carter MJ,Kim HJ,West JJ,Thomas LJ,He LZ,Keler T,Johnson PWM,Al-Shamkhani A,Thirdborough SM,Beers SA,Cragg MS,Glennie MJ,Lim SH

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Mon Dec 11 00:00:00 EST 2017

Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.

The Journal of clinical investigation

Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

The Journal of experimental medicine

Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Mon Jun 05 00:00:00 EDT 2017

Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice.

Neurobiology of disease

MacPherson KP,Sompol P,Kannarkat GT,Chang J,Sniffen L,Wildner ME,Norris CM,Tansey MG

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Thu Jun 01 00:00:00 EDT 2017

The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice.

Journal of immunology (Baltimore, Md. : 1950)

Sitrin J,Suto E,Wuster A,Eastham-Anderson J,Kim JM,Austin CD,Lee WP,Behrens TW

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Tue Aug 15 00:00:00 EDT 2017

Batf3-dependent CD8α⁺ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.

EBioMedicine

Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

Extrafollicular CD4⁺ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.

Nature communications

Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

Ceramide synthesis regulates T cell activity and GVHD development.

JCI insight

Sofi MH,Heinrichs J,Dany M,Nguyen H,Dai M,Bastian D,Schutt S,Wu Y,Daenthanasanmak A,Gencer S,Zivkovic A,Szulc Z,Stark H,Liu C,Chang YJ,Ogretmen B,Yu XZ

15-0621 was used in Flow cytometry/Cell sorting to define the involvement of ceramides in the T-cell response to alloantigens present after allogeneic haematopoietic cell transplantation.

Thu May 18 00:00:00 EDT 2017

Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome.

Journal of immunology (Baltimore, Md. : 1950)

Li JT,Melton AC,Su G,Hamm DE,LaFemina M,Howard J,Fang X,Bhat S,Huynh KM,O'Kane CM,Ingram RJ,Muir RR,McAuley DF,Matthay MA,Sheppard D

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2015

Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model.

BioMed research international

Olsen DS,Goar WA,Nichols BA,Bailey KT,Christensen SL,Merriam KR,Reynolds PR,Wilson E,Weber KS,Bridgewater LC

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

Myelin-specific T helper 17 cells promote adult hippocampal neurogenesis through indirect mechanisms.

F1000Research

Niebling J,E Rünker A,Schallenberg S,Kretschmer K,Kempermann G

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Fri Mar 06 00:00:00 EST 2020

STAT4 is required for IL-23 responsiveness in Th17 memory cells and NKT cells.

JAK-STAT

Glosson-Byers NL,Sehra S,Kaplan MH

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2015

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

The Journal of clinical investigation

Dai X,James RG,Habib T,Singh S,Jackson S,Khim S,Moon RT,Liggitt D,Wolf-Yadlin A,Buckner JH,Rawlings DJ

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Wed May 01 00:00:00 EDT 2013

Hepatocyte-specific S100a8 and S100a9 transgene expression in mice causes Cxcl1 induction and systemic neutrophil enrichment.

Cell communication and signaling : CCS

Wiechert L,Németh J,Pusterla T,Bauer C,De Ponti A,Manthey S,Marhenke S,Vogel A,Klingmüller U,Hess J,Angel P

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Sat Dec 15 00:00:00 EST 2012

H2 control of natural T regulatory cell frequency in the lymph node correlates with susceptibility to day 3 thymectomy-induced autoimmune disease.

Journal of immunology (Baltimore, Md. : 1950)

del Rio R,Sun Y,Alard P,Tung KS,Teuscher C

15-0621 was used in Flow cytometry/Cell sorting to confirm that quantitative trait loci on a range of chromosomes control susceptibility to autoimmune ovarian dysgenesis.

Sat Jan 01 00:00:00 EST 2011

Modeling Sjögren's syndrome with Id3 conditional knockout mice.

Immunology letters

Guo Z,Li H,Han M,Xu T,Wu X,Zhuang Y

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Wed Mar 30 00:00:00 EDT 2011

IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.

Journal of immunology (Baltimore, Md. : 1950)

Unsinger J,McGlynn M,Kasten KR,Hoekzema AS,Watanabe E,Muenzer JT,McDonough JS,Tschoep J,Ferguson TA,McDunn JE,Morre M,Hildeman DA,Caldwell CC,Hotchkiss RS

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Thu Apr 01 00:00:00 EDT 2010

Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice.

Blood

Peng B,Ye P,Blazar BR,Freeman GJ,Rawlings DJ,Ochs HD,Miao CH

15-0621 was used in Flow cytometry/Cell sorting to study the formation of inhibitory antibodies during treatment of hemophilia, showing that transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII.

Mon Sep 01 00:00:00 EDT 2008

Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection.

Infection and immunity

Anis MM,Fulton SA,Reba SM,Harding CV,Boom WH

Published figure using CD62L (L-Selectin) monoclonal antibody (Product # 15-0621-82) in Flow Cytometry

Tue May 01 00:00:00 EDT 2007

Bioinformatics

Protein Aliases: CD62 antigen-like family member L; CD62L; hLHRc; L-selectin; LAM-1; LECAM1; Leu-8; Leukocyte adhesion molecule 1; Leukocyte-endothelial cell adhesion molecule 1; Ly-22; Lymph node homing receptor; Lymphocyte antigen 22; Lymphocyte surface MEL-14 antigen

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Gene Aliases: AI528707; CD62L; L-selectin; LECAM-1; Lnhr; Ly-22; Ly-m22; Ly22; Lyam-1; Lyam1; Sell

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UniProt ID: (Mouse) P18337

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Entrez Gene ID: (Mouse) 20343

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Function(s)

protease binding protein binding carbohydrate binding cell adhesion molecule binding glycolipid binding

Process(es)

cell adhesion response to ATP regulation of apoptotic process positive regulation of neutrophil chemotaxis

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD62L (L-Selectin) Monoclonal Antibody (MEL-14), PE-Cyanine5, eBioscience™

CD62L (L-Selectin) Antibody (15-0621-82) in Flow

Product Details

15-0621-82

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

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Bioinformatics

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