Product References
Forsythiaside A Improves the Inhibitory Efficiency of Recombinant Protein Vaccines against Bovine Viral Diarrhea Virus Infection.
International journal of molecular sciences
Yang G,Wang J,Wang S,Zhu Y
Published figure using IL-2 monoclonal antibody (Product # 17-7021-82) in Flow Cytometry
Sat Aug 20 00:00:00 EDT 2022
In vivo genome-wide CRISPR screening identifies ZNF24 as a negative NF-κB modulator in lung cancer.
Cell & bioscience
Liu L,Lei Y,Chen W,Zhou Q,Zheng Z,Zeng G,Liu W,Feng P,Zhang Z,Yu L,Chen L
Published figure using IL-2 monoclonal antibody (Product # 17-7021-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2022
Z. morio Hemolymph Relieves E. coli-Induced Mastitis by Inhibiting Inflammatory Response and Repairing the Blood-Milk Barrier.
International journal of molecular sciences
Zou Y,Wang X,Xu J,Wang S,Li S,Zhu Y,Wang J
17-7021-82 was used in Flow cytometry/Cell sorting to reveal that Z. morio hemolymph alleviates E. coli-induced mastitis via lessening the inflammatory response by regulating the NLRP3 and ATG5/ATG16L1 signaling pathway, as well as repairing the blood-milk barrier.
Mon Oct 31 00:00:00 EDT 2022
Z. morio Hemolymph Relieves E. coli-Induced Mastitis by Inhibiting Inflammatory Response and Repairing the Blood-Milk Barrier.
International journal of molecular sciences
Zou Y,Wang X,Xu J,Wang S,Li S,Zhu Y,Wang J
17-7021-82 was used in Flow cytometry/Cell sorting to reveal that Z. morio hemolymph alleviates E. coli-induced mastitis via lessening the inflammatory response by regulating the NLRP3 and ATG5/ATG16L1 signaling pathway, as well as repairing the blood-milk barrier.
Mon Oct 31 00:00:00 EDT 2022
Lysosomal acid lipase, CSF1R, and PD-L1 determine functions of CD11c+ myeloid-derived suppressor cells.
JCI insight
Zhao T,Liu S,Ding X,Johnson EM,Hanna NH,Singh K,Sen CK,Wan J,Du H,Yan C
17-7021-82 was used in Flow cytometry/Cell sorting to investigate if CD11c+ cells switched their functions to immune suppression and tumor growth stimulation through CSF1R/PD-L1 upregulation and metabolic reprogramming.
Thu Sep 08 00:00:00 EDT 2022
Elective nodal irradiation mitigates local and systemic immunity generated by combination radiation and immunotherapy in head and neck tumors.
Nature communications
Darragh LB,Gadwa J,Pham TT,Van Court B,Neupert B,Olimpo NA,Nguyen K,Nguyen D,Knitz MW,Hoen M,Corbo S,Joshi M,Zhuang Y,Amann M,Wang XJ,Dow S,Kedl RM,Samedi V,Boss MK,Karam SD
17-7021-82 was used in Flow cytometry/Cell sorting to support using lymphatic sparing radiation therapy for head and neck cancer.
Wed Nov 16 00:00:00 EST 2022
Impaired Treg-DC interactions contribute to autoimmunity in leukocyte adhesion deficiency type 1.
JCI insight
Klaus T,Wilson AS,Vicari E,Hadaschik E,Klein M,Helbich SSC,Kamenjarin N,Hodapp K,Schunke J,Haist M,Butsch F,Probst HC,Enk AH,Mahnke K,Waisman A,Bednarczyk M,Bros M,Bopp T,Grabbe S
Published figure using IL-2 monoclonal antibody (Product # 17-7021-82) in Flow Cytometry
Thu Dec 22 00:00:00 EST 2022
A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candidate Provides Complete Protection against SARS-CoV-2 Infection in Hamsters.
Journal of virology
Lu M,Zhang Y,Dravid P,Li A,Zeng C,Kc M,Trivedi S,Sharma H,Chaiwatpongsakorn S,Zani A,Kenney A,Cai C,Ye C,Liang X,Qiu J,Martinez-Sobrido L,Yount JS,Boyaka PN,Liu SL,Peeples ME,Kapoor A,Li J
Published figure using IL-2 monoclonal antibody (Product # 17-7021-82) in Flow Cytometry
Mon Sep 27 00:00:00 EDT 2021
In Vivo Antigen Expression Regulates CD4 T Cell Differentiation and Vaccine Efficacy against Mycobacterium tuberculosis Infection.
mBio
Clemmensen HS,Dube JY,McIntosh F,Rosenkrands I,Jungersen G,Aagaard C,Andersen P,Behr MA,Mortensen R
17-7021-82 was used in Flow cytometry/Cell sorting to demonstrate that immunization with such antigens can counteract this phenomenon by maintaining antigen-specific T cells in a state of low differentiation.
Tue Apr 20 00:00:00 EDT 2021
Antigen-driven EGR2 expression is required for exhausted CD8+ T cell stability and maintenance.
Nature communications
Wagle MV,Vervoort SJ,Kelly MJ,Van Der Byl W,Peters TJ,Martin BP,Martelotto LG,Nüssing S,Ramsbottom KM,Torpy JR,Knight D,Reading S,Thia K,Miosge LA,Howard DR,Gloury R,Gabriel SS,Utzschneider DT,Oliaro J,Powell JD,Luciani F,Trapani JA,Johnstone RW,Kallies A,Goodnow CC,Parish IA
17-7021-82 was used in Flow cytometry/Cell sorting to show that persistent antigen recognition drives higher EGR2 expression within exhausted versus effector CD8+T cells.
Thu May 13 00:00:00 EDT 2021
Local Sustained GM-CSF Delivery by Genetically Engineered Encapsulated Cells Enhanced Both Cellular and Humoral SARS-CoV-2 Spike-Specific Immune Response in an Experimental Murine Spike DNA Vaccination Model.
Vaccines
Vernet R,Charrier E,Cosset E,Fièvre S,Tomasello U,Grogg J,Mach N
17-7021-82 was used in Flow Cytometry to investigate whether murine Granulocyte-macrophage colony-stimulating factor (GM-CSF) represents a suitable adjuvant for SARS-CoV-2 immunization.
Mon May 10 00:00:00 EDT 2021
Local Sustained GM-CSF Delivery by Genetically Engineered Encapsulated Cells Enhanced Both Cellular and Humoral SARS-CoV-2 Spike-Specific Immune Response in an Experimental Murine Spike DNA Vaccination Model.
Vaccines
Vernet R,Charrier E,Cosset E,Fièvre S,Tomasello U,Grogg J,Mach N
17-7021-82 was used in Flow Cytometry to investigate whether murine Granulocyte-macrophage colony-stimulating factor (GM-CSF) represents a suitable adjuvant for SARS-CoV-2 immunization.
Mon May 10 00:00:00 EDT 2021
Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors.
EMBO molecular medicine
Fan Z,Tian Y,Chen Z,Liu L,Zhou Q,He J,Coleman J,Dong C,Li N,Huang J,Xu C,Zhang Z,Gao S,Zhou P,Ding K,Chen L
Published figure using IL-2 monoclonal antibody (Product # 17-7021-82) in Flow Cytometry
Mon Jun 08 00:00:00 EDT 2020
Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from Plasmodium Challenge in a Mouse Model.
Vaccines
Reeder SM,Reuschel EL,Bah MA,Yun K,Tursi NJ,Kim KY,Chu J,Zaidi FI,Yilmaz I,Hart RJ,Perrin B,Xu Z,Humeau L,Weiner DB,Aly ASI
Published figure using IL-2 monoclonal antibody (Product # 17-7021-82) in Flow Cytometry
Fri Jan 10 00:00:00 EST 2020
Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses.
NPJ vaccines
Brar G,Farhat NA,Sukhina A,Lam AK,Kim YH,Hsu T,Tong L,Lin WW,Ware CF,Blackman MA,Sun R,Wu TT
Published figure using IL-2 monoclonal antibody (Product # 17-7021-82) in Flow Cytometry
Thu Nov 05 00:00:00 EST 2020
Modulation of Vaccine-Induced HIV-1-Specific Immune Responses by Co-Electroporation of PD-L1 Encoding DNA.
Vaccines
Tannig P,Peter AS,Lapuente D,Klessing S,Damm D,Tenbusch M,Überla K,Temchura V
17-7021-82 was used in Flow Cytometry to indicate that co-electroporation of soluble checkpoint ectodomains together with DNA-based vaccines has modulatory effects on vaccine-induced immune responses that could improve vaccine efficacies.
Tue Jan 14 00:00:00 EST 2020
Rescuing ESAT-6 Specific CD4 T Cells From Terminal Differentiation Is Critical for Long-Term Control of Murine Mtb Infection.
Frontiers in immunology
Clemmensen HS,Knudsen NPH,Billeskov R,Rosenkrands I,Jungersen G,Aagaard C,Andersen P,Mortensen R
17-7021-81 was used in Flow Cytometry to show long term control of murine mycobacterium tuberculosis infection is facilitated by rescue of ESAT-6 specific CD4 T cells.
Mon Jun 14 00:00:00 EDT 2021
miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival.
Cell reports
Gagnon JD,Kageyama R,Shehata HM,Fassett MS,Mar DJ,Wigton EJ,Johansson K,Litterman AJ,Odorizzi P,Simeonov D,Laidlaw BJ,Panduro M,Patel S,Jeker LT,Feeney ME,McManus MT,Marson A,Matloubian M,Sanjabi S,Ansel KM
Published figure using IL-2 monoclonal antibody (Product # 17-7021-82) in Flow Cytometry
Tue Aug 20 00:00:00 EDT 2019
Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment.
The Journal of experimental medicine
Lee SH,Charmoy M,Romano A,Paun A,Chaves MM,Cope FO,Ralph DA,Sacks DL
17-7021 was used in Flow cytometry/Cell sorting to study the origin and functional specialisation of dermal macrophages in cutaneous infections.
Tue Jan 02 00:00:00 EST 2018
Molecular architecture and regulation of BCL10-MALT1 filaments.
Nature communications
Schlauderer F,Seeholzer T,Desfosses A,Gehring T,Strauss M,Hopfner KP,Gutsche I,Krappmann D,Lammens K
17-7021 was used in Flow cytometry/Cell sorting to develop a model for the assembly and architecture of the CARD11-BCL10-MALT1 signalling complex and how it functions as a signalling hub in T-lymphocytes.
Tue Oct 02 00:00:00 EDT 2018
Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.
The Journal of clinical investigation
Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF
Published figure using IL-2 monoclonal antibody (Product # 17-7021-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
Vaccination with High-Affinity Epitopes Impairs Antitumor Efficacy by Increasing PD-1 Expression on CD8+ T Cells.
Cancer immunology research
Zahm CD,Colluru VT,McNeel DG
17-7021 was used in Flow cytometry/Cell sorting to investigate whether the dose, MHC affinity, or TCR affinity of an epitope affected the antitumor response via the PD-1/PD-L1 axis in mice.
Tue Aug 01 00:00:00 EDT 2017
A New Adjuvant MTOM Mediates Mycobacterium tuberculosis Subunit Vaccine to Enhance Th1-Type T Cell Immune Responses and IL-2+ T Cells.
Frontiers in immunology
Yu Q,Wang X,Fan X
Wed Nov 20 00:00:00 EST 2019
Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.
Nature communications
Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J
Published figure using IL-2 monoclonal antibody (Product # 17-7021-82) in Flow Cytometry
Wed Oct 11 00:00:00 EDT 2017
A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation.
EBioMedicine
Ma J,Teng X,Wang X,Fan X,Wu Y,Tian M,Zhou Z,Li L
Published figure using IL-2 monoclonal antibody (Product # 17-7021-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2017
NFATc1 controls the cytotoxicity of CD8+ T cells.
Nature communications
Klein-Hessling S,Muhammad K,Klein M,Pusch T,Rudolf R,Flöter J,Qureischi M,Beilhack A,Vaeth M,Kummerow C,Backes C,Schoppmeyer R,Hahn U,Hoth M,Bopp T,Berberich-Siebelt F,Patra A,Avots A,Müller N,Schulze A,Serfling E
17-7021 was used in Flow cytometry/Cell sorting to indicate that NFATc1 is an important regulator of cytotoxic T lymphocyte effector functions.
Mon Sep 11 00:00:00 EDT 2017
NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.
Nature communications
Alrefai H,Muhammad K,Rudolf R,Pham DA,Klein-Hessling S,Patra AK,Avots A,Bukur V,Sahin U,Tenzer S,Goebeler M,Kerstan A,Serfling E
17-7021 was used in Flow cytometry/Cell sorting to indicate a close link between NFATc1 and IL-10 expression in B cells, suggesting that NFATc1 may be a potential target to treat human psoriasis.
Wed May 25 00:00:00 EDT 2016
Mycobacterium tuberculosis multistage antigens confer comprehensive protection against pre- and post-exposure infections by driving Th1-type T cell immunity.
Oncotarget
Ma J,Tian M,Fan X,Yu Q,Jing Y,Wang W,Li L,Zhou Z
17-7021 was used in Flow cytometry/Cell sorting to suggest that multistage-specific antigens could be targets for the next generation TB vaccine.
Tue Sep 27 00:00:00 EDT 2016
Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells.
Nature communications
Meininger I,Griesbach RA,Hu D,Gehring T,Seeholzer T,Bertossi A,Kranich J,Oeckinghaus A,Eitelhuber AC,Greczmiel U,Gewies A,Schmidt-Supprian M,Ruland J,Brocker T,Heissmeyer V,Heyd F,Krappmann D
17-7021 was used in Flow cytometry/Cell sorting to study how TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation.
Tue Apr 12 00:00:00 EDT 2016
Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.
Human vaccines & immunotherapeutics
Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X
17-7021 was used in Flow cytometry/Cell sorting to show the immunogenicity and protective efficacy of the DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.
Fri Mar 11 00:00:00 EST 2016
Inadequate activation of the HBsAg-specific Th cells by APCs leads to hyporesponsiveness to HBsAg vaccine in B10.S mice.
Human vaccines & immunotherapeutics
Li X,Xu J,Lv Z,Wang J,Sun S,Zhu W,Wang B,He R,Qu D
17-7021 was used in Flow cytometry/Cell sorting to study how the activities of APCs were significantly lower in mice immunised with HBsAg vaccine, resulting in an inferior activation of HBsAg-specific Th cells.
Tue Apr 19 00:00:00 EDT 2016
Protection against Mycobacterium tuberculosis infection offered by a new multistage subunit vaccine correlates with increased number of IFN-γ+ IL-2+ CD4+ and IFN-γ+ CD8+ T cells.
PloS one
Wang X,Zhang J,Liang J,Zhang Y,Teng X,Yuan X,Fan X
17-7021 was used in Flow cytometry/Cell sorting to investigate protein subunit vaccinations for control of tuberculosis, showing that a new multistage subunit vaccine increases numbers of T cells and protects against TB.
Wed Mar 09 00:00:00 EST 2016
TLR2 engagement on CD4(+) T cells enhances effector functions and protective responses to Mycobacterium tuberculosis.
European journal of immunology
Reba SM,Li Q,Onwuzulike S,Ding X,Karim AF,Hernandez Y,Fulton SA,Harding CV,Lancioni CL,Nagy N,Rodriguez ME,Wearsch PA,Rojas RE
Published figure using IL-2 monoclonal antibody (Product # 17-7021-82) in Flow Cytometry
Thu May 01 00:00:00 EDT 2014
High-frequency vaccine-induced CD8⁺ T cells specific for an epitope naturally processed during infection with Mycobacterium tuberculosis do not confer protection.
European journal of immunology
Lindenstrøm T,Aagaard C,Christensen D,Agger EM,Andersen P
17-7021 was used in Flow cytometry/Cell sorting to study the role of CD8 T cells in resistance to mycobacterial infections.
Sun Jun 01 00:00:00 EDT 2014
The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis.
Nature communications
Kuwahara M,Suzuki J,Tofukuji S,Yamada T,Kanoh M,Matsumoto A,Maruyama S,Kometani K,Kurosaki T,Ohara O,Nakayama T,Yamashita M
17-7021 was used in Flow cytometry/Cell sorting to show that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, which is accompanied by the senescence-associated secretory phenotype after antigenic stimulation and dysregulated cytokine production.
Wed Apr 02 00:00:00 EDT 2014
IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
PLoS pathogens
Schmitz I,Schneider C,Fröhlich A,Frebel H,Christ D,Leonard WJ,Sparwasser T,Oxenius A,Freigang S,Kopf M
17-7021 was used in Flow cytometry/Cell sorting to investigate the role of Foxp3+ regulatory T (Treg) cells during viral infections, showing that IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
Mon Dec 09 00:00:00 EST 2013
Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Baine I,Basu S,Ames R,Sellers RS,Macian F
17-7021 was used in Flow cytometry/Cell sorting to identify that the transcription factor, Helios, maintains the anergic phenotype of Tregs by suppressing transcription of interleukin 2.
Fri Feb 01 00:00:00 EST 2013
The Thai phase III trial (RV144) vaccine regimen induces T cell responses that preferentially target epitopes within the V2 region of HIV-1 envelope.
Journal of immunology (Baltimore, Md. : 1950)
de Souza MS,Ratto-Kim S,Chuenarom W,Schuetz A,Chantakulkij S,Nuntapinit B,Valencia-Micolta A,Thelian D,Nitayaphan S,Pitisuttithum P,Paris RM,Kaewkungwal J,Michael NL,Rerks-Ngarm S,Mathieson B,Marovich M,Currier JR,Kim JH
17-7021 was used in Flow cytometry/Cell sorting to reveal T cell response of HIV-1 vaccine recipients was directed to a particular region of viral envelope.
Tue May 15 00:00:00 EDT 2012
The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin.
PloS one
Qi Y,Operario DJ,Georas SN,Mosmann TR
17-7021 was used in Flow cytometry/Cell sorting to collate a detailed analysis of the regulation of Amphiregulin expression by human T cell subsets.
Thu Dec 13 00:00:00 EST 2012
Epstein-Barr virus latent membrane protein 2A exacerbates experimental autoimmune encephalomyelitis and enhances antigen presentation function.
Scientific reports
Chang RA,Miller SD,Longnecker R
17-7021 was used in an ELISpot assay to investigate the Epstein-Barr virus as a possible etiological agent involved in multiple sclerosis.
Mon Feb 25 00:00:00 EST 2013
CD4+ T cells modulate expansion and survival but not functional properties of effector and memory CD8+ T cells induced by malaria sporozoites.
PloS one
Overstreet MG,Chen YC,Cockburn IA,Tse SW,Zavala F
17-7021 was used in Flow cytometry/Cell sorting to investigate CD4+ T cells modulation of effector and memory CD8+ T cells, induced by malaria sporozoites.
Tue Jan 04 00:00:00 EST 2011
IL-21 deficiency influences CD8 T cell quality and recall responses following an acute viral infection.
Journal of immunology (Baltimore, Md. : 1950)
Yi JS,Ingram JT,Zajac AJ
17-7021 was used in Flow cytometry/Cell sorting to investigate the importance of IL-21 in determining CD8 T cell function, quality and maintenance following lymphocytic choriomeningitis virus infection in mice.
Fri Oct 15 00:00:00 EDT 2010
Dendritic cell and NK cell reciprocal cross talk promotes gamma interferon-dependent immunity to blood-stage Plasmodium chabaudi AS infection in mice.
Infection and immunity
Ing R,Stevenson MM
17-7021 was used in Immunofluorescence to elucidate the signalling mechanisms underlying interferon-γ-dependent immunity to malaria.
Sun Feb 01 00:00:00 EST 2009
