Product References
Swarna Bhasma Induces Antigen-Presenting Abilities of Macrophages and Helps Antigen Experienced CD4+ T Cells to Acquire Th1 Phenotypes Against Leishmania donovani Antigens.
Biological trace element research
Saini S,Anand A,Singh A,Mahapatra B,Sirohi S,Singh S,Singh RK
12-7021-82 was used in Flow cytometry/Cell sorting to suggest a definite potential of swarna bhasma in enhancing the effector functions of phagocytes and CD4+ T cells against L. donovani antigens.
Mon Jan 01 00:00:00 EST 2024
Forsythiaside A Improves the Inhibitory Efficiency of Recombinant Protein Vaccines against Bovine Viral Diarrhea Virus Infection.
International journal of molecular sciences
Yang G,Wang J,Wang S,Zhu Y
Published figure using IL-2 monoclonal antibody (Product # 12-7021-82) in Flow Cytometry
Sat Aug 20 00:00:00 EDT 2022
In vivo genome-wide CRISPR screening identifies ZNF24 as a negative NF-κB modulator in lung cancer.
Cell & bioscience
Liu L,Lei Y,Chen W,Zhou Q,Zheng Z,Zeng G,Liu W,Feng P,Zhang Z,Yu L,Chen L
12-7021-82 was used in Flow cytometry/Cell sorting to reveal an important role played by loss of function of ZNF24 in lung tumorigenesis and shed new light in precision medicine for a portion of lung cancer patients.
Thu Dec 01 00:00:00 EST 2022
In vivo genome-wide CRISPR screening identifies ZNF24 as a negative NF-κB modulator in lung cancer.
Cell & bioscience
Liu L,Lei Y,Chen W,Zhou Q,Zheng Z,Zeng G,Liu W,Feng P,Zhang Z,Yu L,Chen L
12-7021-82 was used in Flow cytometry/Cell sorting to reveal an important role played by loss of function of ZNF24 in lung tumorigenesis and shed new light in precision medicine for a portion of lung cancer patients.
Thu Dec 01 00:00:00 EST 2022
Z. morio Hemolymph Relieves E. coli-Induced Mastitis by Inhibiting Inflammatory Response and Repairing the Blood-Milk Barrier.
International journal of molecular sciences
Zou Y,Wang X,Xu J,Wang S,Li S,Zhu Y,Wang J
Published figure using IL-2 monoclonal antibody (Product # 12-7021-82) in Flow Cytometry
Mon Oct 31 00:00:00 EDT 2022
Impaired Treg-DC interactions contribute to autoimmunity in leukocyte adhesion deficiency type 1.
JCI insight
Klaus T,Wilson AS,Vicari E,Hadaschik E,Klein M,Helbich SSC,Kamenjarin N,Hodapp K,Schunke J,Haist M,Butsch F,Probst HC,Enk AH,Mahnke K,Waisman A,Bednarczyk M,Bros M,Bopp T,Grabbe S
Published figure using IL-2 monoclonal antibody (Product # 12-7021-82) in Flow Cytometry
Thu Dec 22 00:00:00 EST 2022
A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candidate Provides Complete Protection against SARS-CoV-2 Infection in Hamsters.
Journal of virology
Lu M,Zhang Y,Dravid P,Li A,Zeng C,Kc M,Trivedi S,Sharma H,Chaiwatpongsakorn S,Zani A,Kenney A,Cai C,Ye C,Liang X,Qiu J,Martinez-Sobrido L,Yount JS,Boyaka PN,Liu SL,Peeples ME,Kapoor A,Li J
Published figure using IL-2 monoclonal antibody (Product # 12-7021-82) in Flow Cytometry
Mon Sep 27 00:00:00 EDT 2021
Local Sustained GM-CSF Delivery by Genetically Engineered Encapsulated Cells Enhanced Both Cellular and Humoral SARS-CoV-2 Spike-Specific Immune Response in an Experimental Murine Spike DNA Vaccination Model.
Vaccines
Vernet R,Charrier E,Cosset E,Fièvre S,Tomasello U,Grogg J,Mach N
Published figure using IL-2 monoclonal antibody (Product # 12-7021-82) in Flow Cytometry
Mon May 10 00:00:00 EDT 2021
MEF2D sustains activation of effector Foxp3+ Tregs during transplant survival and anticancer immunity.
The Journal of clinical investigation
Di Giorgio E,Wang L,Xiong Y,Akimova T,Christensen LM,Han R,Samanta A,Trevisanut M,Bhatti TR,Beier UH,Hancock WW
12-7021 was used in Flow cytometry/Cell sorting to study the role played by MEF2D in sustaining effector Foxp3+ Treg functions without abrogating their basal actions suggests its suitability for drug discovery efforts in cancer therapy.
Tue Dec 01 00:00:00 EST 2020
Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors.
EMBO molecular medicine
Fan Z,Tian Y,Chen Z,Liu L,Zhou Q,He J,Coleman J,Dong C,Li N,Huang J,Xu C,Zhang Z,Gao S,Zhou P,Ding K,Chen L
12-7021 was used in Flow cytometry/Cell sorting to determine steps within PD-1 signalling pathway that can be targeted in anticancer drugs.
Mon Jun 08 00:00:00 EDT 2020
Blocking interaction between SHP2 and PD-1 denotes a novel opportunity for developing PD-1 inhibitors.
EMBO molecular medicine
Fan Z,Tian Y,Chen Z,Liu L,Zhou Q,He J,Coleman J,Dong C,Li N,Huang J,Xu C,Zhang Z,Gao S,Zhou P,Ding K,Chen L
12-7021 was used in Flow cytometry/Cell sorting to determine steps within PD-1 signalling pathway that can be targeted in anticancer drugs.
Mon Jun 08 00:00:00 EDT 2020
Synthetic DNA Vaccines Adjuvanted with pIL-33 Drive Liver-Localized T Cells and Provide Protection from Plasmodium Challenge in a Mouse Model.
Vaccines
Reeder SM,Reuschel EL,Bah MA,Yun K,Tursi NJ,Kim KY,Chu J,Zaidi FI,Yilmaz I,Hart RJ,Perrin B,Xu Z,Humeau L,Weiner DB,Aly ASI
Published figure using IL-2 monoclonal antibody (Product # 12-7021-82) in Flow Cytometry
Fri Jan 10 00:00:00 EST 2020
Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses.
NPJ vaccines
Brar G,Farhat NA,Sukhina A,Lam AK,Kim YH,Hsu T,Tong L,Lin WW,Ware CF,Blackman MA,Sun R,Wu TT
Published figure using IL-2 monoclonal antibody (Product # 12-7021-82) in Flow Cytometry
Thu Nov 05 00:00:00 EST 2020
PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell-Driven Antitumor Immunity.
Clinical cancer research : an official journal of the American Association for Cancer Research
Buchan SL,Fallatah M,Thirdborough SM,Taraban VY,Rogel A,Thomas LJ,Penfold CA,He LZ,Curran MA,Keler T,Al-Shamkhani A
12-7021 was used in Flow cytometry/Cell sorting to show that suboptimal T-cell invigoration in cancer patients undergoing treatment with PD-1 checkpoint blockers will be improved by dual PD-1 blockade and CD27 agonism.
Tue May 15 00:00:00 EDT 2018
Herpes Zoster DNA Vaccines with IL-7 and IL-33 Molecular Adjuvants Elicit Protective T Cell Immunity.
Immune network
Kim AR,Park J,Kim JH,Kwak JE,Cho Y,Lee H,Jeong M,Park SH,Shin EC
12-7021 was used in Flow cytometry/Cell sorting to evaluate the T cell immunogenicity of Herpes Zoster DNA vaccines.
Mon Oct 01 00:00:00 EDT 2018
Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.
The Journal of clinical investigation
Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF
Published figure using IL-2 monoclonal antibody (Product # 12-7021-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
Vaccination with High-Affinity Epitopes Impairs Antitumor Efficacy by Increasing PD-1 Expression on CD8+ T Cells.
Cancer immunology research
Zahm CD,Colluru VT,McNeel DG
Published figure using IL-2 monoclonal antibody (Product # 12-7021-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2017
A New Adjuvant MTOM Mediates Mycobacterium tuberculosis Subunit Vaccine to Enhance Th1-Type T Cell Immune Responses and IL-2+ T Cells.
Frontiers in immunology
Yu Q,Wang X,Fan X
Published figure using IL-2 monoclonal antibody (Product # 12-7021-82) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.
Nature communications
Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J
Published figure using IL-2 monoclonal antibody (Product # 12-7021-82) in Flow Cytometry
Wed Oct 11 00:00:00 EDT 2017
A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation.
EBioMedicine
Ma J,Teng X,Wang X,Fan X,Wu Y,Tian M,Zhou Z,Li L
Published figure using IL-2 monoclonal antibody (Product # 12-7021-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2017
TGF-β receptor maintains CD4 T helper cell identity during chronic viral infections.
The Journal of clinical investigation
Lewis GM,Wehrens EJ,Labarta-Bajo L,Streeck H,Zuniga EI
12-7021 was used in Flow cytometry/Cell sorting to uncover an eomesodermin-driven CD4 T cell program that is continuously suppressed by TGF-β signalling.
Mon Oct 03 00:00:00 EDT 2016
Trypanosoma brucei Co-opts NK Cells to Kill Splenic B2 B Cells.
PLoS pathogens
Frenkel D,Zhang F,Guirnalda P,Haynes C,Bockstal V,Radwanska M,Magez S,Black SJ
12-7021 was used in Flow cytometry/Cell sorting to investigate the mechanism by which natural killer cells in Trypanosoma brucei infected mice kill B cells, suppress humoral immunity and induce early mortality.
Fri Jul 01 00:00:00 EDT 2016
miR-150 regulates obesity-associated insulin resistance by controlling B cell functions.
Scientific reports
Ying W,Tseng A,Chang RC,Wang H,Lin YL,Kanameni S,Brehm T,Morin A,Jones B,Splawn T,Criscitiello M,Golding MC,Bazer FW,Safe S,Zhou B
12-7021 was used in Flow cytometry/Cell sorting to demonstrate a role for miR-150 in regulating B cell functions in adipose tissue.
Mon Feb 01 00:00:00 EST 2016
mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors.
Scientific reports
Wu T,Zhao Y,Wang H,Li Y,Shao L,Wang R,Lu J,Yang Z,Wang J,Zhao Y
12-7021 was used in Flow cytometry/Cell sorting to offer evidence supporting that mTOR is an intrinsic factor essential for the differentiation and immunosuppressive function of M-MDSCs.
Mon Feb 01 00:00:00 EST 2016
IFN-β Selectively Inhibits IL-2 Production through CREM-Mediated Chromatin Remodeling.
Journal of immunology (Baltimore, Md. : 1950)
Otero DC,Fares-Frederickson NJ,Xiao M,Baker DP,David M
12-7021 was used in Flow cytometry/Cell sorting to investigate the mechanism by which interferon beta limits T cell responses and its potential therapeutic use for multiple sclerosis.
Mon Jun 01 00:00:00 EDT 2015
Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.
Human vaccines & immunotherapeutics
Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X
Published figure using IL-2 monoclonal antibody (Product # 12-7021-82) in Flow Cytometry
Fri Mar 11 00:00:00 EST 2016
Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors.
Oncotarget
Colbeck EJ,Hindley JP,Smart K,Jones E,Bloom A,Bridgeman H,McPherson RC,Turner DG,Ladell K,Price DA,O'Connor RA,Anderton SM,Godkin AJ,Gallimore AM
12-7021 was used in Flow cytometry/Cell sorting to study the enrichment of tumor-infiltrating Treg populations and assess the role of IL-2 in pertubation of Treg frequencies in tumors.
Tue Sep 22 00:00:00 EDT 2015
TLR2 engagement on CD4(+) T cells enhances effector functions and protective responses to Mycobacterium tuberculosis.
European journal of immunology
Reba SM,Li Q,Onwuzulike S,Ding X,Karim AF,Hernandez Y,Fulton SA,Harding CV,Lancioni CL,Nagy N,Rodriguez ME,Wearsch PA,Rojas RE
12-7021-82 was used in Flow cytometry/Cell sorting to examine the role of CD4(+) T-cell-expressed TLR2 in Mycobacterium tuberculosis (MTB) Ag-specific T-cell priming and in protection against MTB infection in vivo.
Thu May 01 00:00:00 EDT 2014
TLR2 engagement on CD4(+) T cells enhances effector functions and protective responses to Mycobacterium tuberculosis.
European journal of immunology
Reba SM,Li Q,Onwuzulike S,Ding X,Karim AF,Hernandez Y,Fulton SA,Harding CV,Lancioni CL,Nagy N,Rodriguez ME,Wearsch PA,Rojas RE
12-7021-82 was used in Flow cytometry/Cell sorting to examine the role of CD4(+) T-cell-expressed TLR2 in Mycobacterium tuberculosis (MTB) Ag-specific T-cell priming and in protection against MTB infection in vivo.
Thu May 01 00:00:00 EDT 2014
Immunosuppression by N-methyl-D-aspartate receptor antagonists is mediated through inhibition of Kv1.3 and KCa3.1 channels in T cells.
Molecular and cellular biology
Kahlfuß S,Simma N,Mankiewicz J,Bose T,Lowinus T,Klein-Hessling S,Sprengel R,Schraven B,Heine M,Bommhardt U
12-7021 was used in Flow cytometry/Cell sorting to investigate the effect of NMDAR antagonists on T-cell function, showing that antagonists cause immunosuppression via inhibition of Kv1.3 and KCa3.1 channels in T-cells.
Sat Mar 01 00:00:00 EST 2014
A new recombinant BCG vaccine induces specific Th17 and Th1 effector cells with higher protective efficacy against tuberculosis.
PloS one
da Costa AC,Costa-Júnior Ade O,de Oliveira FM,Nogueira SV,Rosa JD,Resende DP,Kipnis A,Junqueira-Kipnis AP
12-7021 was used in Flow cytometry/Cell sorting to evaluate the immunogenicity and protection of a new BCG vaccine against TB, showing that it induces specific Th17 and Th1 effector cells with higher protective efficacy.
Fri Dec 18 00:00:00 EST 2015
ZBTB1 is a determinant of lymphoid development.
The Journal of experimental medicine
Siggs OM,Li X,Xia Y,Beutler B
12-7021 was used in Flow cytometry/Cell sorting to identify a mutation causative of complete and cell-intrinsic T cell deficiency.
Mon Jan 16 00:00:00 EST 2012
The location of splenic NKT cells favours their rapid activation by blood-borne antigen.
The EMBO journal
Barral P,Sánchez-Niño MD,van Rooijen N,Cerundolo V,Batista FD
12-7021 was used in an ELISA assay to study the distribution and dynamics of natural killer T cells within the spleen.
Wed May 16 00:00:00 EDT 2012
Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization.
Journal of immunology (Baltimore, Md. : 1950)
Schmidt NW,Harty JT
12-7021 was used in Flow cytometry/Cell sorting to investigate whether unrelated infections will compromise numbers of Plasmodium-specific memory CD8 T cells, showing that attrition of Plasmodium-specific cells is rescued by booster immunisation.
Fri Apr 01 00:00:00 EDT 2011
Development of memory-like autoregulatory CD8+ T cells is CD4+ T cell dependent.
Journal of immunology (Baltimore, Md. : 1950)
Shameli A,Clemente-Casares X,Wang J,Santamaria P
12-7021 was used in Flow cytometry/Cell sorting to demonstrate the CD4+ T cell-dependent nature of the differentiation of a memory-like autoregulatory T cell population in chronic autoimmune responses.
Thu Sep 15 00:00:00 EDT 2011
Combining liver- and blood-stage malaria viral-vectored vaccines: investigating mechanisms of CD8+ T cell interference.
Journal of immunology (Baltimore, Md. : 1950)
Forbes EK,Biswas S,Collins KA,Gilbert SC,Hill AV,Draper SJ
12-7021 was used in Flow cytometry/Cell sorting to investigate the various mechanisms of CD8(+) T cell interference and the implications for the development of a multistage or multicomponent viral vectored malaria vaccine for use in humans.
Sat Oct 01 00:00:00 EDT 2011
CD8+CD122+ regulatory T cells (Tregs) and CD4+ Tregs cooperatively prevent and cure CD4+ cell-induced colitis.
Journal of immunology (Baltimore, Md. : 1950)
Endharti AT,Okuno Y,Shi Z,Misawa N,Toyokuni S,Ito M,Isobe K,Suzuki H
12-7021 was used in Flow cytometry/Cell sorting to investigate the role of CD8(+)CD122(+) regulatory T cells (Tregs) in maintenance of immune homeostasis, showing that CD8(+)CD122(+) Tregs and CD4+ Tregs cooperatively prevent and cure CD4+ cell-induced colitis.
Sat Jan 01 00:00:00 EST 2011
IL-1β promotes TGF-β1 and IL-2 dependent Foxp3 expression in regulatory T cells.
PloS one
Ganesh BB,Bhattacharya P,Gopisetty A,Sheng J,Vasu C,Prabhakar BS
12-7021 was used in an ELISA assay to investigate the differential effects of IL-12 and IL-1β on Foxp3 expression in T cells, showing that IL-1β promotes TGF-β1- and IL-2-dependent Foxp3 expression in Tregs.
Tue Nov 15 00:00:00 EST 2011
Postthymic maturation influences the CD8 T cell response to antigen.
Proceedings of the National Academy of Sciences of the United States of America
Makaroff LE,Hendricks DW,Niec RE,Fink PJ
12-7021 was used in Flow cytometry/Cell sorting to demonstrate that the post-thymic maturation stage influences cell fate decisions and cytokine profiles of stimulated CD8 T-cells.
Tue Mar 24 00:00:00 EDT 2009
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation.
Journal of immunology (Baltimore, Md. : 1950)
Lal G,Zhang N,van der Touw W,Ding Y,Ju W,Bottinger EP,Reid SP,Levy DE,Bromberg JS
12-7021 was used in Functional assays to investigate Foxp3 as the master switch for Tregs, showing that expression is regulated by DNA methylation in Tregs.
Thu Jan 01 00:00:00 EST 2009
Cross-presentation of male seminal fluid antigens elicits T cell activation to initiate the female immune response to pregnancy.
Journal of immunology (Baltimore, Md. : 1950)
Moldenhauer LM,Diener KR,Thring DM,Brown MP,Hayball JD,Robertson SA
12-7021 was used in Flow cytometry/Cell sorting to study how at conception, seminal fluid drives activation and expansion of paternal Ag-reactive CD4(+) and CD8(+) T cell populations.
Mon Jun 15 00:00:00 EDT 2009
Dicer-dependent microRNA pathway safeguards regulatory T cell function.
The Journal of experimental medicine
Liston A,Lu LF,O'Carroll D,Tarakhovsky A,Rudensky AY
12-7021 was used in Flow cytometry/Cell sorting to study regulatory T cell-mediated tolerance, showing that it is dependent on the Dicer-controlled microRNA pathway.
Mon Sep 01 00:00:00 EDT 2008
Adjuvants targeting innate and adaptive immunity synergize to enhance tumor immunotherapy.
Proceedings of the National Academy of Sciences of the United States of America
Verdeil G,Marquardt K,Surh CD,Sherman LA
12-7021 was used in Flow cytometry/Cell sorting to study the combined use of two types of immune adjuvants that synergise to enhance tumour immunotherapy.
Tue Oct 28 00:00:00 EDT 2008
TRAIL deficiency does not rescue impaired CD8+ T cell memory generated in the absence of CD4+ T cell help.
Journal of immunology (Baltimore, Md. : 1950)
Sacks JA,Bevan MJ
12-7021 was used in Flow cytometry/Cell sorting to investigate the role of the proapoptotic molecule TRAIL in unhelped CD8(+) T cells.
Tue Apr 01 00:00:00 EDT 2008
Role of Valpha14+ NKT cells in the development of Hepatitis B virus-specific CTL: activation of Valpha14+ NKT cells promotes the breakage of CTL tolerance.
International immunology
Ito H,Ando K,Ishikawa T,Nakayama T,Taniguchi M,Saito K,Imawari M,Moriwaki H,Yokochi T,Kakumu S,Seishima M
12-7021 was used in Flow cytometry/Cell sorting to open up a new method for clearing the virus from patients with persistent HBV infection.
Tue Jul 01 00:00:00 EDT 2008
The surprising kinetics of the T cell response to live antigenic cells.
Journal of immunology (Baltimore, Md. : 1950)
Tyznik AJ,Bevan MJ
12-7021 was used in Flow cytometry/Cell sorting to demonstrate dramatic differences in host T cell responses to noninflammatory Ags compared with responses to pathogens.
Mon Oct 15 00:00:00 EDT 2007
Prolongation of allograft survival by administration of anti-CD45RB monoclonal antibody is due to alteration of CD45RBhi: CD45RBlo T-cell proportions.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Luke PP,Deng JP,Lian D,O'Connell PJ,Garcia B,Jevnikar AM,Zhong R
12-7021 was used in Flow cytometry/Cell sorting to assess the importance of CD45RBhi T-cell depletion in murine cardiac allograft survival.
Fri Sep 01 00:00:00 EDT 2006
Human ILT2 receptor associates with murine MHC class I molecules in vivo and impairs T cell function.
European journal of immunology
Liang S,Zhang W,Horuzsko A
12-7021 was used in Flow cytometry/Cell sorting to study the function of immunoglobulin-like transcript 2 in vivo.
Fri Sep 01 00:00:00 EDT 2006
