Invitrogen

CD44 Monoclonal Antibody (IM7), PE-Cyanine7, eBioscience™

FIGURE: 1 / 99

CD44 Antibody (25-0441-82) in Flow

Staining of C57BL/6 splenocytes with 0.06 µg of Rat IgG2b K Isotype Control PE-Cyanine7 (Product # 25-4031-82) (open histogram) or 0.06 µg of Anti-Human/Mouse CD44 PE-Cyanine7 (filled histogram). Cells in the lymphocyte gate were used for analysis.

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Product Details

25-0441-82

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

0.125 µg/test

View 229 publications 229 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Fruit fly, Human, Mouse, Non-human primate

Host/Isotype

Rat / IgG2b, kappa

Recommended Isotype Control

Rat IgG2b kappa Isotype Control (eB149/10H5), PE-Cyanine7, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

IM7

Conjugate

PE-Cyanine7 PE-Cyanine7 PE-Cyanine7

Excitation/Emission Max

569/780 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_469623

Product Specific Information

Description: The IM7 monoclonal antibody reacts with all isoforms of mouse CD44 (Pgp-1). CD44 is expressed by hematopoietic and non-hematopoietic cells. Bone marrow myeloid cells and memory T cells highly express this antigen and peripheral B and T cells can upregulate the expression of CD44. CD44 functions as an adhesion molecule through its binding to hyaluronate, an extracellular matrix component.

Applications Reported: This IM7 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This IM7 antibody has been tested by flow cytometric analysis of mouse bone marrow cells and splenocytes. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Light sensitivity: This tandem dye is sensitive photo-induced oxidation. Please protect this vial and stained samples from light.

Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-822-49) (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product # 00-5333-54) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.

Excitation: 488-561 nm; Emission: 775 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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25-0441-82 was used in Flow cytometry/Cell sorting to reveal that diverse epigenetic barriers underly resistance to reprogramming of transformed cells.

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FUS-DDIT3 Fusion Oncoprotein Expression Affects JAK-STAT Signaling in Myxoid Liposarcoma.

Frontiers in oncology

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WDR82-binding long noncoding RNA lncEry controls mouse erythroid differentiation and maturation.

The Journal of experimental medicine

Yang S,Sun G,Wu P,Chen C,Kuang Y,Liu L,Zheng Z,He Y,Gu Q,Lu T,Zhu C,Wang F,Gou F,Yang Z,Zhao X,Yuan S,Yang L,Lu S,Li Y,Lv X,Dong F,Ma Y,Yu J,Ng LG,Shi L,Liu J,Shi L,Cheng T,Cheng H

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CD44 Promotes Breast Cancer Metastasis through AKT-Mediated Downregulation of Nuclear FOXA2.

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Frontiers in immunology

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PloS one

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Cell reports

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Cancers

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iScience

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Nature communications

Li H,Wang M,Huang B,Zhu SW,Zhou JJ,Chen DR,Cui R,Zhang M,Sun ZJ

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International journal of molecular sciences

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Cell reports

Kinsella S,Evandy CA,Cooper K,Iovino L,deRoos PC,Hopwo KS,Granadier DW,Smith CW,Rafii S,Dudakov JA

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STAR protocols

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Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

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EBioMedicine

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Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

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Cell death discovery

Gan G,Shi Z,Liu D,Zhang S,Zhu H,Wang Y,Mi J

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

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Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

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The Journal of biological chemistry

Zhao Y,Cheng R,Zhao Y,Ge W,Yang Y,Ding Z,Xu X,Wang Z,Wu Z,Zhang J

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

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Nature communications

Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure.

Cell death & disease

Yu H,Yang W,Huang J,Miao X,Wang B,Ren X,Gu Y,Wang Q,Ding X,Guo X,Qian F,Zhang Y,Xu H,Zheng L,Jin M

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

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Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.

Frontiers in immunology

Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F

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Tue Jan 11 00:00:00 EST 2022

Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2-expressing Treg cells.

Proceedings of the National Academy of Sciences of the United States of America

Ronin E,Pouchy C,Khosravi M,Hilaire M,Grégoire S,Casrouge A,Kassem S,Sleurs D,Martin GH,Chanson N,Lombardi Y,Lalle G,Wajant H,Auffray C,Lucas B,Marodon G,Grinberg-Bleyer Y,Salomon BL

25-0441-82 was used in Flow cytometry/Cell sorting to show that endogenous Treg cells specifically suppress an autoimmune disease by acting in the target tissue during overt inflammation.

Tue Mar 30 00:00:00 EDT 2021

Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.

STAR protocols

Skordos I,Demeyer A,Beyaert R

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Mar 19 00:00:00 EDT 2021

Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.

Immunity

Bonavita E,Bromley CP,Jonsson G,Pelly VS,Sahoo S,Walwyn-Brown K,Mensurado S,Moeini A,Flanagan E,Bell CR,Chiang SC,Chikkanna-Gowda CP,Rogers N,Silva-Santos B,Jaillon S,Mantovani A,Reis e Sousa C,Guerra N,Davis DM,Zelenay S

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Dec 15 00:00:00 EST 2020

Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4⁺ T Cell Pathogenicity and Suppresses Autoimmunity.

Cell metabolism

Angiari S,Runtsch MC,Sutton CE,Palsson-McDermott EM,Kelly B,Rana N,Kane H,Papadopoulou G,Pearce EL,Mills KHG,O'Neill LAJ

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Feb 04 00:00:00 EST 2020

Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.

The Journal of clinical investigation

Webb LM,Sengupta S,Edell C,Piedra-Quintero ZL,Amici SA,Miranda JN,Bevins M,Kennemer A,Laliotis G,Tsichlis PN,Guerau-de-Arellano M

25-0441 was used in Flow cytometry/Cell sorting to demonstrate that PRMT5 expression in recently activated T cells is necessary for the cholesterol biosynthesis metabolic gene expression program that generates RORγt agonistic activity and promotes Th17 differentiation and EAE.

Wed Apr 01 00:00:00 EDT 2020

Transfer of metastatic traits via miR-200c in extracellular vesicles derived from colorectal cancer stem cells is inhibited by atractylenolide I.

Clinical and translational medicine

Tang D,Xu X,Ying J,Xie T,Cao G

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Sat Aug 01 00:00:00 EDT 2020

Distinct roles of PIK3CA in the enrichment and maintenance of cancer stem cells in head and neck squamous cell carcinoma.

Molecular oncology

Chen X,Cao Y,Sedhom W,Lu L,Liu Y,Wang H,Oka M,Bornstein S,Said S,Song J,Lu SL

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

Down-Regulated Exosomal MicroRNA-221 - 3p Derived From Senescent Mesenchymal Stem Cells Impairs Heart Repair.

Frontiers in cell and developmental biology

Sun L,Zhu W,Zhao P,Zhang J,Lu Y,Zhu Y,Zhao W,Liu Y,Chen Q,Zhang F

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Dexamethasone inhibits stemness maintenance and enhances chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation of HIF‑1α and Oct4.

International journal of oncology

Jiang Z,Zhang C,Liu X,Ma X,Bian X,Xiao X,Gao R,Sun Y,Wu W,Zhao P

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2020

Extracellular HMGB-1 activates inflammatory signaling in tendon cells and tissues.

Therapeutic advances in chronic disease

Zhang C,Gu X,Zhao G,Wang W,Shao J,Zhu J,Yuan T,Sun J,Nie D,Zhou Y

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Sun Apr 17 00:00:00 EDT 2022

miR‑210 enhances mesenchymal stem cell‑modulated neural precursor cell migration.

Molecular medicine reports

Wang F,Zhu J,Zheng J,Duan W,Zhou Z

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2020

Identification, characterization and microRNA expression profiling of side population cells in human oral squamous cell carcinoma Tca8113 cell lines.

Molecular medicine reports

Luo W,Liu RS,E LL,Bai Y,Kong XP,Liu HW,Wu H,Liu HC

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2020

Resveratrol rescues TNF‑α‑induced inhibition of osteogenesis in human periodontal ligament stem cells via the ERK1/2 pathway.

Molecular medicine reports

Yuan J,Wang X,Ma D,Gao H,Zheng D,Zhang J

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2020

Critical role of WNK1 in MYC-dependent early mouse thymocyte development.

eLife

Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Wed Oct 14 00:00:00 EDT 2020

Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses.

eLife

Lee J,Zhang J,Chung YJ,Kim JH,Kook CM,González-Navajas JM,Herdman DS,Nürnberg B,Insel PA,Corr M,Mo JH,Tao A,Yasuda K,Rifkin IR,Broide DH,Sciammas R,Webster NJ,Raz E

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Feb 04 00:00:00 EST 2020

Effect of Combining Low Temperature Plasma, Negative Pressure Wound Therapy, and Bone Marrow Mesenchymal Stem Cells on an Acute Skin Wound Healing Mouse Model.

International journal of molecular sciences

Cui HS,Joo SY,Cho YS,Park JH,Kim JB,Seo CH

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Sat May 23 00:00:00 EDT 2020

Targeted expression profiling reveals distinct stages of early canine fibroblast reprogramming are regulated by 2-oxoglutarate hydroxylases.

Stem cell research & therapy

Tobias IC,Kao MC,Parmentier T,Hunter H,LaMarre J,Betts DH

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Wed Dec 09 00:00:00 EST 2020

Chemotherapeutic Stress Influences Epithelial-Mesenchymal Transition and Stemness in Cancer Stem Cells of Triple-Negative Breast Cancer.

International journal of molecular sciences

Li X,Strietz J,Bleilevens A,Stickeler E,Maurer J

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Wed Jan 08 00:00:00 EST 2020

Inhibition of EZH2 ameliorates bacteria-induced liver injury by repressing RUNX1 in dendritic cells.

Cell death & disease

Wang Y,Wang Q,Wang B,Gu Y,Yu H,Yang W,Ren X,Qian F,Zhao X,Xiao Y,Zhang Y,Jin M,Zhu M

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer.

Cancers

Witschen PM,Chaffee TS,Brady NJ,Huggins DN,Knutson TP,LaRue RS,Munro SA,Tiegs L,McCarthy JB,Nelson AC,Schwertfeger KL

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri May 22 00:00:00 EDT 2020

Utility Evaluation of Porcine Enteroids as PDCoV Infection Model in vitro.

Frontiers in microbiology

Luo H,Zheng J,Chen Y,Wang T,Zhang Z,Shan Y,Xu J,Yue M,Fang W,Li X

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Head and Neck Cancer Stem Cell-Enriched Spheroid Model for Anticancer Compound Screening.

Cells

Goričan L,Gole B,Potočnik U

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Thu Jul 16 00:00:00 EDT 2020

Obesity-Altered Adipose Stem Cells Promote Radiation Resistance of Estrogen Receptor Positive Breast Cancer through Paracrine Signaling.

International journal of molecular sciences

Sabol RA,Villela VA,Denys A,Freeman BT,Hartono AB,Wise RM,Harrison MAA,Sandler MB,Hossain F,Miele L,Bunnell BA

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Wed Apr 15 00:00:00 EDT 2020

CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling.

Cell death & disease

Huang R,Wang S,Wang N,Zheng Y,Zhou J,Yang B,Wang X,Zhang J,Guo L,Wang S,Chen Z,Wang Z,Xiang S

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Thu Apr 16 00:00:00 EDT 2020

Profiling and Targeting of Energy and Redox Metabolism in Grade 2 Bladder Cancer Cells with Different Invasiveness Properties.

Cells

Pasquale V,Ducci G,Campioni G,Ventrici A,Assalini C,Busti S,Vanoni M,Vago R,Sacco E

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Dec 11 00:00:00 EST 2020

Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals.

Cell & bioscience

Jiang M,Ye J,Wang X,Li N,Wang Y,Shi Y

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Thu Apr 14 00:00:00 EDT 2022

MicroRNA-9 Fine-Tunes Dendritic Cell Function by Suppressing Negative Regulators in a Cell-Type-Specific Manner.

Cell reports

Cordeiro B,Jeon P,Boukhaled GM,Corrado M,Lapohos O,Roy DG,Williams K,Jones RG,Gruenheid S,Sagan SM,Krawczyk CM

25-0441 was used in Flow cytometry/Cell sorting to demonstrate that miR-9 facilitates the transition of DCs from steady state to mature state by regulating the expression of several negative regulators of DC function in a cell-type-specific manner.

Tue May 05 00:00:00 EDT 2020

Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.

Nature communications

Sidwell T,Liao Y,Garnham AL,Vasanthakumar A,Gloury R,Blume J,Teh PP,Chisanga D,Thelemann C,de Labastida Rivera F,Engwerda CR,Corcoran L,Kometani K,Kurosaki T,Smyth GK,Shi W,Kallies A

25-0441 was used in Flow cytometry/Cell sorting to show homeostasis of thymically-derived and peripherally-derived Treg cells is maintained through the balancing of TCR signaling induced transcriptional activity by Bach2.

Tue Jan 14 00:00:00 EST 2020

Requirements for the differentiation of innate T-bet^high memory-phenotype CD4⁺ T lymphocytes under steady state.

Nature communications

Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Mon Jul 06 00:00:00 EDT 2020

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.

Nature communications

Toubal A,Kiaf B,Beaudoin L,Cagninacci L,Rhimi M,Fruchet B,da Silva J,Corbett AJ,Simoni Y,Lantz O,Rossjohn J,McCluskey J,Lesnik P,Maguin E,Lehuen A

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Jul 24 00:00:00 EDT 2020

Localized cocktail chemoimmunotherapy after in situ gelation to trigger robust systemic antitumor immune responses.

Science advances

Chao Y,Liang C,Tao H,Du Y,Wu D,Dong Z,Jin Q,Chen G,Xu J,Xiao Z,Chen Q,Wang C,Chen J,Liu Z

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2020

The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.

Cell

Collins N,Han SJ,Enamorado M,Link VM,Huang B,Moseman EA,Kishton RJ,Shannon JP,Dixit D,Schwab SR,Hickman HD,Restifo NP,McGavern DB,Schwartzberg PL,Belkaid Y

25-0441-82 was used in Flow Cytometry to show that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction (DR) but dramatically accumulated within the bone marrow (BM), where they adopted a state associated with energy conservation.

Thu Aug 22 00:00:00 EDT 2019

The cis-Regulatory Atlas of the Mouse Immune System.

Cell

Yoshida H,Lareau CA,Ramirez RN,Rose SA,Maier B,Wroblewska A,Desland F,Chudnovskiy A,Mortha A,Dominguez C,Tellier J,Kim E,Dwyer D,Shinton S,Nabekura T,Qi Y,Yu B,Robinette M,Kim KW,Wagers A,Rhoads A,Nutt SL,Brown BD,Mostafavi S,Buenrostro JD,Benoist C

25-0441-82 was used in Flow Cytometry to generate matched epigenome and transcriptome measurements in 86 primary cell types that span the mouse immune system and its differentiation cascade.

Thu Feb 07 00:00:00 EST 2019

The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4⁺ T Cell Peripheralization to Promote Effective Adaptive Immunity.

Immunity

Baptista AP,Gola A,Huang Y,Milanez-Almeida P,Torabi-Parizi P,Urban JF,Shapiro VS,Gerner MY,Germain RN

25-0441 was used in Flow cytometry/Cell sorting to demonstrate evolutionary selection for distinct niches within the LN that promote cellular responses, emphasizing the critical link between fine-grained tissue organization and host defense.

Tue May 21 00:00:00 EDT 2019

A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation.

Circulation research

Lu X,Rudemiller NP,Wen Y,Ren J,Hammer GE,Griffiths R,Privratsky JR,Yang B,Sparks MA,Crowley SD

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Dec 06 00:00:00 EST 2019

A Novel Form of 4-1BBL Prevents Cancer Development via Nonspecific Activation of CD4⁺ T and Natural Killer Cells.

Cancer research

Barsoumian HB,Batra L,Shrestha P,Bowen WS,Zhao H,Egilmez NK,Gomez-Gutierrez JG,Yolcu ES,Shirwan H

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Feb 15 00:00:00 EST 2019

Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice.

Genome research

Alriyami M,Marchand L,Li Q,Du X,Olivier M,Polychronakos C

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Sun Dec 01 00:00:00 EST 2019

The ROP16III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival.

PLoS pathogens

Tuladhar S,Kochanowsky JA,Bhaskara A,Ghotmi Y,Chandrasekaran S,Koshy AA

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Anisomycin inhibits angiogenesis in ovarian cancer by attenuating the molecular sponge effect of the lncRNA‑Meg3/miR‑421/PDGFRA axis.

International journal of oncology

Ye W,Ni Z,Yicheng S,Pan H,Huang Y,Xiong Y,Liu T

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Sun Dec 01 00:00:00 EST 2019

Hypoxia changes chemotaxis behaviour of mesenchymal stem cells via HIF-1α signalling.

Journal of cellular and molecular medicine

Xu W,Xu R,Li Z,Wang Y,Hu R

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2019

Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro.

Stem cells international

Sun B,Luo X,Yang C,Liu P,Yang Y,Dong X,Yang Z,Xu J,Zhang Y,Li L

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Thu May 13 00:00:00 EDT 2021

HMGB3 silence inhibits breast cancer cell proliferation and tumor growth by interacting with hypoxia-inducible factor 1α.

Cancer management and research

Gu J,Xu T,Huang QH,Zhang CM,Chen HY

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Sep 29 00:00:00 EDT 2020

TGF‑β induces periodontal ligament stem cell senescence through increase of ROS production.

Molecular medicine reports

Fan C,Ji Q,Zhang C,Xu S,Sun H,Li Z

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Effects of demographic factors on adipogenic and chondrogenic differentiation in bone marrow-derived stem cells.

Experimental and therapeutic medicine

Lee H,Min SK,Park JB

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Wed May 01 00:00:00 EDT 2019

The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway.

EBioMedicine

Seo D,Jung SM,Park JS,Lee J,Ha J,Kim M,Park SH

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Nov 01 00:00:00 EDT 2019

BRCA1 regulates the cancer stem cell fate of breast cancer cells in the context of hypoxia and histone deacetylase inhibitors.

Scientific reports

Kim H,Lin Q,Yun Z

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Thu Jul 04 00:00:00 EDT 2019

Visfatin Mediates Malignant Behaviors through Adipose-Derived Stem Cells Intermediary in Breast Cancer.

Cancers

Huang JY,Wang YY,Lo S,Tseng LM,Chen DR,Wu YC,Hou MF,Yuan SF

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Dec 20 00:00:00 EST 2019

Better therapeutic potential of bone marrow-derived mesenchymal stem cells compared with chorionic villi-derived mesenchymal stem cells in airway injury model.

Regenerative medicine

Ji S,Wu C,Tong L,Wang L,Zhou J,Chen C,Song Y

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2019

Overexpression of Aiolos promotes epithelial-mesenchymal transition and cancer stem cell-like properties in lung cancer cells.

Scientific reports

Hung JJ,Kao YS,Huang CH,Hsu WH

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Thu Feb 28 00:00:00 EST 2019

BMX-ARHGAP fusion protein maintains the tumorigenicity of gastric cancer stem cells by activating the JAK/STAT3 signaling pathway.

Cancer cell international

Xu XF,Gao F,Wang JJ,Long C,Chen X,Tao L,Yang L,Ding L,Ji Y

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Apr 08 00:00:00 EDT 2022

Sex Differences in Mouse Popliteal Lymph Nodes.

Scientific reports

Dill-Garlow R,Chen KE,Walker AM

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Wed Jan 30 00:00:00 EST 2019

ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.

Nature communications

Cao Y,Trillo-Tinoco J,Sierra RA,Anadon C,Dai W,Mohamed E,Cen L,Costich TL,Magliocco A,Marchion D,Klar R,Michel S,Jaschinski F,Reich RR,Mehrotra S,Cubillos-Ruiz JR,Munn DH,Conejo-Garcia JR,Rodriguez PC

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Wed Mar 20 00:00:00 EDT 2019

Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair.

Cell reports

Colunga T,Hayworth M,Kreß S,Reynolds DM,Chen L,Nazor KL,Baur J,Singh AM,Loring JF,Metzger M,Dalton S

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Mar 05 00:00:00 EST 2019

Restricted Expression of the Thymoproteasome Is Required for Thymic Selection and Peripheral Homeostasis of CD8⁺ T Cells.

Cell reports

Tomaru U,Konno S,Miyajima S,Kimoto R,Onodera M,Kiuchi S,Murata S,Ishizu A,Kasahara M

25-0441 was used in Flow cytometry/Cell sorting to find that thymoproteasomes are essential for positive selection but that the subsequent change in peptide repertoire in the medulla is also crucial for thymic selection and that β5t-derived peptide must be confined to the thymus to avoid autoimmunity in peripheral tissues.

Tue Jan 15 00:00:00 EST 2019

Growth Factor Screening in Dystrophic Muscles Reveals PDGFB/PDGFRB-Mediated Migration of Interstitial Stem Cells.

International journal of molecular sciences

Camps J,Grosemans H,Gijsbers R,Maes C,Sampaolesi M

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Mar 05 00:00:00 EST 2019

Conserved regulation of RNA processing in somatic cell reprogramming.

BMC genomics

Kanitz A,Syed AP,Kaji K,Zavolan M

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Thu Jan 31 00:00:00 EST 2019

Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation.

The Journal of experimental medicine

Shin B,Kress RL,Kramer PA,Darley-Usmar VM,Bellis SL,Harrington LE

25-0441 was used in Flow cytometry/Cell sorting to indicate that the chronicity of T cell-mediated inflammation is perpetuated by specific effector CD4 T cells with stem-like properties.

Mon Jul 02 00:00:00 EDT 2018

Bryostatin-1 alleviates experimental multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Feb 27 00:00:00 EST 2018

Subcellular Localization of Antigen in Keratinocytes Dictates Delivery of CD4⁺ T-cell Help for the CTL Response upon Therapeutic DNA Vaccination into the Skin.

Cancer immunology research

Bąbała N,Bovens A,de Vries E,Iglesias-Guimarais V,Ahrends T,Krummel MF,Borst J,Bins AD

25-0441 was used in Flow cytometry/Cell sorting to demonstrate that tight junction protein-1 cannot be used as a marker of tight junctions in a variety of cells.

Sun Jul 01 00:00:00 EDT 2018

Langerin⁺ CD8α⁺ Dendritic Cells Drive Early CD8⁺ T Cell Activation and IL-12 Production During Systemic Bacterial Infection.

Frontiers in immunology

Prendergast KA,Daniels NJ,Petersen TR,Hermans IF,Kirman JR

25-0441 was used in Flow cytometry/Cell sorting to investigate the impact of depleting langerin+ CD8α+ dendritic cells in a murine model of intravenous infection with Mycobacterium bovis bacille Calmette-Guerin.

Mon Jul 01 00:00:00 EDT 2019

Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.

Oncogene

Solomon H,Dinowitz N,Pateras IS,Cooks T,Shetzer Y,Molchadsky A,Charni M,Rabani S,Koifman G,Tarcic O,Porat Z,Kogan-Sakin I,Goldfinger N,Oren M,Harris CC,Gorgoulis VG,Rotter V

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Thu Mar 01 00:00:00 EST 2018

The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells.

Breast cancer research : BCR

Kim H,Lin Q,Glazer PM,Yun Z

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Mar 06 00:00:00 EST 2018

SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer.

The Journal of cell biology

Viotti M,Wilson C,McCleland M,Koeppen H,Haley B,Jhunjhunwala S,Klijn C,Modrusan Z,Arnott D,Classon M,Stephan JP,Mellman I

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Mon Feb 05 00:00:00 EST 2018

Exogenous IL-6 induces mRNA splice variant MBD2_v2 to promote stemness in TP53 wild-type, African American PCa cells.

Molecular oncology

Teslow EA,Bao B,Dyson G,Legendre C,Mitrea C,Sakr W,Carpten JD,Powell I,Bollig-Fischer A

25-0441 was used in Flow cytometry/Cell sorting to identify genes showing differential tumour versus non-cancer adjacent tissue expression patterns unique to African American men or European American men.

Fri Jun 01 00:00:00 EDT 2018

Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43.

Experimental and therapeutic medicine

Li Z,Zhang S,Cao L,Li W,Ye YC,Shi ZX,Wang ZR,Sun LX,Wang JW,Jia LT,Wang W

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

mTOR Modulates CD8+ T Cell Differentiation in Mice with Invasive Pulmonary Aspergillosis.

Open life sciences

Wang H,Xiao Y,Su L,Cui N,Liu D

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Mon Jan 01 00:00:00 EST 2018

Inactivation of TRPM7 kinase in mice results in enlarged spleens, reduced T-cell proliferation and diminished store-operated calcium entry.

Scientific reports

Beesetty P,Wieczerzak KB,Gibson JN,Kaitsuka T,Luu CT,Matsushita M,Kozak JA

25-0441 was used in Flow cytometry/Cell sorting to study the role of TRPM7 channel kinase as a novel modulator of blastogenesis, proliferation and store-operated calcium entry.

Wed Feb 14 00:00:00 EST 2018

Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.

Nature communications

Sun C,Lan P,Han Q,Huang M,Zhang Z,Xu G,Song J,Wang J,Wei H,Zhang J,Sun R,Zhang C,Tian Z

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Wed Mar 28 00:00:00 EDT 2018

Inhibition of Fas associated phosphatase 1 (Fap1) facilitates apoptosis of colon cancer stem cells and enhances the effects of oxaliplatin.

Oncotarget

Huang W,Bei L,Eklund EA

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri May 25 00:00:00 EDT 2018

An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer.

eLife

Li J,Choi PS,Chaffer CL,Labella K,Hwang JH,Giacomelli AO,Kim JW,Ilic N,Doench JG,Ly SH,Dai C,Hagel K,Hong AL,Gjoerup O,Goel S,Ge JY,Root DE,Zhao JJ,Brooks AN,Weinberg RA,Hahn WC

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Mon Jul 30 00:00:00 EDT 2018

A protocol for generating induced T cells by reprogramming B cells in vivo.

Cell regeneration (London, England)

Weng Q,Hu F,Zhang M,Dong Y,Lv C,Wang Y,Liu X,Wang J

25-0441-82 was used in Flow cytometry/Cell sorting to describe a protocol for generating functional T cells from Hoxb5-expressing B cells in vivo.

Sat Sep 01 00:00:00 EDT 2018

A protocol for generating induced T cells by reprogramming B cells in vivo.

Cell regeneration (London, England)

Weng Q,Hu F,Zhang M,Dong Y,Lv C,Wang Y,Liu X,Wang J

25-0441-82 was used in Flow cytometry/Cell sorting to describe a protocol for generating functional T cells from Hoxb5-expressing B cells in vivo.

Sat Sep 01 00:00:00 EDT 2018

Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.

Nature communications

Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Thu Nov 08 00:00:00 EST 2018

RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.

The Journal of biological chemistry

Ge J,Burnier L,Adamopoulou M,Kwa MQ,Schaks M,Rottner K,Brakebusch C

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Jun 15 00:00:00 EDT 2018

Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.

Immunity, inflammation and disease

Omodho B,Miao T,Symonds ALJ,Singh R,Li S,Wang P

25-0441 was used in Flow cytometry/Cell sorting to show that despite impaired proliferation and IL2 production, tolerant T cells can display inflammatory responses in response to antigen stimulation and this is controlled at least partly by Egr2 and 3.

Fri Jun 01 00:00:00 EDT 2018

Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation.

Cell reports

Chiou NT,Kageyama R,Ansel KM

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Dec 18 00:00:00 EST 2018

The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells.

Immunity

Xu L,Huang Q,Wang H,Hao Y,Bai Q,Hu J,Li Y,Wang P,Chen X,He R,Li B,Yang X,Zhao T,Zhang Y,Wang Y,Ou J,Liang H,Wu Y,Zhou X,Ye L

25-0441-82 was used in Flow Cytometry to study the effect of mTORC1 on Tfr cell differentiation by activating the TCF-1-Bcl-6 axis during immunization or infection.

Tue Sep 19 00:00:00 EDT 2017

Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.

Cancer cell

Turaj AH,Hussain K,Cox KL,Rose-Zerilli MJJ,Testa J,Dahal LN,Chan HTC,James S,Field VL,Carter MJ,Kim HJ,West JJ,Thomas LJ,He LZ,Keler T,Johnson PWM,Al-Shamkhani A,Thirdborough SM,Beers SA,Cragg MS,Glennie MJ,Lim SH

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Mon Dec 11 00:00:00 EST 2017

Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity.

Cell metabolism

Westerterp M,Gautier EL,Ganda A,Molusky MM,Wang W,Fotakis P,Wang N,Randolph GJ,D'Agati VD,Yvan-Charvet L,Tall AR

25-0441 was used in Flow cytometry/Cell sorting to identify an essential role of DC cholesterol efflux pathways in maintaining immune tolerance.

Tue Jun 06 00:00:00 EDT 2017

Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.

Cell stem cell

Ruetz T,Pfisterer U,Di Stefano B,Ashmore J,Beniazza M,Tian TV,Kaemena DF,Tosti L,Tan W,Manning JR,Chantzoura E,Ottosson DR,Collombet S,Johnsson A,Cohen E,Yusa K,Linnarsson S,Graf T,Parmar M,Kaji K

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Thu Dec 07 00:00:00 EST 2017

Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.

The Journal of clinical investigation

Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

The Journal of experimental medicine

Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Mon Jun 05 00:00:00 EDT 2017

A transit-amplifying population underpins the efficient regenerative capacity of the testis.

The Journal of experimental medicine

Carrieri C,Comazzetto S,Grover A,Morgan M,Buness A,Nerlov C,O'Carroll D

25-0441 was used in Flow cytometry/Cell sorting to identify a novel population of Neurog3-expressing spermatogonia, essential for efficient testicular regeneration following injury.

Mon Jun 05 00:00:00 EDT 2017

A type 2 cytokine axis for thymus emigration.

The Journal of experimental medicine

White AJ,Baik S,Parnell SM,Holland AM,Brombacher F,Jenkinson WE,Anderson G

25-0441 was used in Flow cytometry/Cell sorting to show the thymic microenvironment expresses the type 2 IL-4R complex and is functionally responsive to its known ligands, IL-4 and IL-13.

Mon Aug 07 00:00:00 EDT 2017

Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells.

Proceedings of the National Academy of Sciences of the United States of America

Bierie B,Pierce SE,Kroeger C,Stover DG,Pattabiraman DR,Thiru P,Liu Donaher J,Reinhardt F,Chaffer CL,Keckesova Z,Weinberg RA

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Mar 21 00:00:00 EDT 2017

Modulation of Endoplasmic Reticulum Stress Controls CD4⁺ T-cell Activation and Antitumor Function.

Cancer immunology research

Thaxton JE,Wallace C,Riesenberg B,Zhang Y,Paulos CM,Beeson CC,Liu B,Li Z

25-0441 was used in Flow cytometry/Cell sorting to investigate whether the endoplasmic reticulum stress response may be important for CD4+ T-cell activation and whether gp96 is integral to this process.

Tue Aug 01 00:00:00 EDT 2017

A role for the histone H2A deubiquitinase MYSM1 in maintenance of CD8⁺ T cells.

Immunology

Förster M,Boora RK,Petrov JC,Fodil N,Albanese I,Kim J,Gros P,Nijnik A

25-0441 was used in Flow cytometry/Cell sorting to investigate the role of MYSM1 in T-cell development.

Mon May 01 00:00:00 EDT 2017

Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8⁺ T-cell Differentiation during the Immune Response to Invasive Pulmonary Aspergillosis.

Chinese medical journal

Cui N,Wang H,Su LX,Zhang JH,Long Y,Liu DW

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Sat May 20 00:00:00 EDT 2017

The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice.

Journal of immunology (Baltimore, Md. : 1950)

Sitrin J,Suto E,Wuster A,Eastham-Anderson J,Kim JM,Austin CD,Lee WP,Behrens TW

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Aug 15 00:00:00 EDT 2017

A high-yield isolation and enrichment strategy for human lung microvascular endothelial cells.

Pulmonary circulation

Gaskill C,Majka SM

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Role of Prolactin in Promotion of Immune Cell Migration into the Mammary Gland.

Journal of mammary gland biology and neoplasia

Dill R,Walker AM

25-0441 was used in Flow cytometry/Cell sorting to investigate the role of prolactin in immune cell recruitment.

Wed Mar 01 00:00:00 EST 2017

Protein Tyrosine Phosphatase Inhibition Prevents Experimental Cerebral Malaria by Precluding CXCR3 Expression on T Cells.

Scientific reports

Van Den Ham KM,Smith LK,Richer MJ,Olivier M

25-0441 was used in Flow cytometry/Cell sorting to demonstrate that inhibition of protein tyrosine phosphatase activity significantly attenuates T cell sequestration within the brain and prevents the development of neuropathology.

Fri Jul 14 00:00:00 EDT 2017

Comparison of Four Protocols to Generate Chondrocyte-Like Cells from Human Induced Pluripotent Stem Cells (hiPSCs).

Stem cell reviews and reports

Suchorska WM,Augustyniak E,Richter M,Trzeciak T

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

IL-12 Influence mTOR to Modulate CD8⁺ T Cells Differentiation through T-bet and Eomesodermin in Response to Invasive Pulmonary Aspergillosis.

International journal of medical sciences

Wang H,Li J,Han Q,Yang F,Xiao Y,Xiao M,Xu Y,Su L,Cui N,Liu D

25-0441 was used in Flow cytometry/Cell sorting to investigate whether the mTOR signalling pathway regulates the proliferation and differentiation of CD8+ T cells in an invasive pulmonary aspergillosis mouse model.

Mon May 21 00:00:00 EDT 2018

Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.

Scientific reports

Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Sep 29 00:00:00 EDT 2017

Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.

Nature communications

Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Wed Oct 11 00:00:00 EDT 2017

Understanding CD8⁺ T-cell responses toward the native and alternate HLA-A*02:01-restricted WT1 epitope.

Clinical & translational immunology

Nguyen TH,Tan AC,Xiang SD,Goubier A,Harland KL,Clemens EB,Plebanski M,Kedzierska K

25-0441-82 was used in Flow cytometry/Cell sorting to investigate HLA in Wilms' tumour 1 antigen.

Wed Mar 01 00:00:00 EST 2017

Understanding CD8⁺ T-cell responses toward the native and alternate HLA-A*02:01-restricted WT1 epitope.

Clinical & translational immunology

Nguyen TH,Tan AC,Xiang SD,Goubier A,Harland KL,Clemens EB,Plebanski M,Kedzierska K

25-0441-82 was used in Flow cytometry/Cell sorting to investigate HLA in Wilms' tumour 1 antigen.

Wed Mar 01 00:00:00 EST 2017

Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling.

Theranostics

Cao Y,Lin SH,Wang Y,Chin YE,Kang L,Mi J

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Mon Apr 30 00:00:00 EDT 2018

IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.

JCI insight

Le Saout C,Luckey MA,Villarino AV,Smith M,Hasley RB,Myers TG,Imamichi H,Park JH,O'Shea JJ,Lane HC,Catalfamo M

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Thu Nov 16 00:00:00 EST 2017

SOCS3 treatment prevents the development of alopecia areata by inhibiting CD8+ T cell-mediated autoimmune destruction.

Oncotarget

Gao Z,Jin YQ,Wu W

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue May 16 00:00:00 EDT 2017

Extrafollicular CD4⁺ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.

Nature communications

Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

Extrafollicular CD4⁺ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.

Nature communications

Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

Distinct Kinase-Independent Role of RIPK3 in CD11c⁺ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair.

Cell reports

Moriwaki K,Balaji S,Bertin J,Gough PJ,Chan FK

25-0441 was used in Flow cytometry/Cell sorting to study the distinct kinase-independent role of RIPK3 in cytokine-induced tissue repair.

Tue Mar 07 00:00:00 EST 2017

Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB.

PloS one

Gao SY,Zheng GS,Wang L,Liang YJ,Zhang SE,Lao XM,Li K,Liao GQ

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Mon Sep 18 00:00:00 EDT 2017

Oligodendrocyte death results in immune-mediated CNS demyelination.

Nature neuroscience

Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

TGF-β receptor maintains CD4 T helper cell identity during chronic viral infections.

The Journal of clinical investigation

Lewis GM,Wehrens EJ,Labarta-Bajo L,Streeck H,Zuniga EI

25-0441 was used in Flow cytometry/Cell sorting to uncover an eomesodermin-driven CD4 T cell program that is continuously suppressed by TGF-β signalling.

Mon Oct 03 00:00:00 EDT 2016

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.

The Journal of experimental medicine

Drennan MB,Govindarajan S,Verheugen E,Coquet JM,Staal J,McGuire C,Taghon T,Leclercq G,Beyaert R,van Loo G,Lambrecht BN,Elewaut D

25-0441 was used in Flow cytometry/Cell sorting to show that negative regulation of TCR signalling during NKT development controls the differentiation and survival of NKT1 and NKT2 cells.

Mon Sep 19 00:00:00 EDT 2016

SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis.

PLoS biology

Kim BR,Van de Laar E,Cabanero M,Tarumi S,Hasenoeder S,Wang D,Virtanen C,Suzuki T,Bandarchi B,Sakashita S,Pham NA,Lee S,Keshavjee S,Waddell TK,Tsao MS,Moghal N

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Nov 01 00:00:00 EDT 2016

Stem Cells Antigen-1 Enriches for a Cancer Stem Cell-Like Subpopulation in Mouse Gastric Cancer.

Stem cells (Dayton, Ohio)

Park JW,Park JM,Park DM,Kim DY,Kim HK

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.

Journal of immunology (Baltimore, Md. : 1950)

Menendez CM,Jinkins JK,Carr DJ

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Mon Aug 15 00:00:00 EDT 2016

Effects of nerve growth factor and basic fibroblast growth factor dual gene modification on rat bone marrow mesenchymal stem cell differentiation into neuron-like cells in vitro.

Molecular medicine reports

Hu Y,Zhang Y,Tian K,Xun C,Wang S,Lv D

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Comparable roles of CD44v8-10 and CD44s in the development of bone metastases in a mouse model.

Oncology letters

Hiraga T,Nakamura H

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2016

Cryptotanshinone targets tumor-initiating cells through down-regulation of stemness genes expression.

Oncology letters

Zhang Y,Cabarcas SM,Zheng JI,Sun L,Mathews LA,Zhang X,Lin H,Farrar WL

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Wed Jun 01 00:00:00 EDT 2016

PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.

Biology open

Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Sun May 15 00:00:00 EDT 2016

Sertoli cell condition medium can induce germ like cells from bone marrow derived mesenchymal stem cells.

Iranian journal of basic medical sciences

Monfared MH,Minaee B,Rastegar T,Khrazinejad E,Barbarestani M

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Nov 01 00:00:00 EDT 2016

A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.

Nature communications

Jeric I,Maurer G,Cavallo AL,Raguz J,Desideri E,Tarkowski B,Parrini M,Fischer I,Zatloukal K,Baccarini M

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Wed Dec 21 00:00:00 EST 2016

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.

Nature communications

Brinkman CC,Iwami D,Hritzo MK,Xiong Y,Ahmad S,Simon T,Hippen KL,Blazar BR,Bromberg JS

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Jun 21 00:00:00 EDT 2016

The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states.

BMC biology

Toneff MJ,Sreekumar A,Tinnirello A,Hollander PD,Habib S,Li S,Ellis MJ,Xin L,Mani SA,Rosen JM

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Jun 17 00:00:00 EDT 2016

Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production.

Stem cell research & therapy

Camilleri ET,Gustafson MP,Dudakovic A,Riester SM,Garces CG,Paradise CR,Takai H,Karperien M,Cool S,Sampen HJ,Larson AN,Qu W,Smith J,Dietz AB,van Wijnen AJ

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Thu Aug 11 00:00:00 EDT 2016

Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration.

Oncotarget

Greenwood E,Maisel S,Ebertz D,Russ A,Pandey R,Schroeder J

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Sep 20 00:00:00 EDT 2016

Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle.

The Journal of clinical investigation

Quattrocelli M,Swinnen M,Giacomazzi G,Camps J,Barthélemy I,Ceccarelli G,Caluwé E,Grosemans H,Thorrez L,Pelizzo G,Muijtjens M,Verfaillie CM,Blot S,Janssens S,Sampaolesi M

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2015

Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.

Cancer research

Zhang S,Chung WC,Wu G,Egan SE,Miele L,Xu K

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri May 15 00:00:00 EDT 2015

Maspin Expression in Prostate Tumor Cells Averts Stemness and Stratifies Drug Sensitivity.

Cancer research

Bernardo MM,Kaplun A,Dzinic SH,Li X,Irish J,Mujagic A,Jakupovic B,Back JB,Van Buren E,Han X,Dean I,Chen YQ,Heath E,Sakr W,Sheng S

25-0441 was used in Flow cytometry/Cell sorting to demonstrate that the tumour suppressor maspin reduces prostate tumour cell plasticity and enhances tumour sensitivity to salinomycin.

Tue Sep 15 00:00:00 EDT 2015

Premature thymic involution is independent of structural plasticity of the thymic stroma.

European journal of immunology

Franckaert D,Schlenner SM,Heirman N,Gill J,Skogberg G,Ekwall O,Put K,Linterman MA,Dooley J,Liston A

25-0441 was used in Flow cytometry/Cell sorting to investigate thymic involution in FVB/N mice, showing that disruption of the epithelial-endothelial relationship and a progressive loss of pro-T cells precedes involution, and loss of pro-T cells is sufficient to drive premature involution, suggesting that pro-T cells are the main driver of involution.

Fri May 01 00:00:00 EDT 2015

Enrichment of Human Stem-Like Prostate Cells with s-SHIP Promoter Activity Uncovers a Role in Stemness for the Long Noncoding RNA H19.

Stem cells and development

Bauderlique-Le Roy H,Vennin C,Brocqueville G,Spruyt N,Adriaenssens E,Bourette RP

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri May 15 00:00:00 EDT 2015

Multi-Drug Resistance ABC Transporter Inhibition Enhances Murine Ventral Prostate Stem/Progenitor Cell Differentiation.

Stem cells and development

Samant MD,Jackson CM,Felix CL,Jones AJ,Goodrich DW,Foster BA,Huss WJ

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri May 15 00:00:00 EDT 2015

Parasite Manipulation of the Invariant Chain and the Peptide Editor H2-DM Affects Major Histocompatibility Complex Class II Antigen Presentation during Toxoplasma gondii Infection.

Infection and immunity

Leroux LP,Nishi M,El-Hage S,Fox BA,Bzik DJ,Dzierszinski FS

25-0441 was used in Flow cytometry/Cell sorting to show that Toxoplasma gondii modulates the expression of key components of the MHC-II antigen presentation pathway in professional antigen-presenting cells.

Thu Oct 01 00:00:00 EDT 2015

Special AT-rich sequence-binding protein-1 participates in the maintenance of breast cancer stem cells through regulation of the Notch signaling pathway and expression of Snail1 and Twist1.

Molecular medicine reports

Sun Z,Zhang C,Zou X,Jiang G,Xu Z,Li W,Xie H

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2015

Reprogramming Roadblocks Are System Dependent.

Stem cell reports

Chantzoura E,Skylaki S,Menendez S,Kim SI,Johnsson A,Linnarsson S,Woltjen K,Chambers I,Kaji K

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Sep 08 00:00:00 EDT 2015

Multi-lineage differentiation of human umbilical cord Wharton's Jelly Mesenchymal Stromal Cells mediates changes in the expression profile of stemness markers.

PloS one

Ali H,Al-Yatama MK,Abu-Farha M,Behbehani K,Al Madhoun A

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Mar 25 00:00:00 EDT 2016

Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.

Cell transplantation

Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Mon Nov 16 00:00:00 EST 2015

Peritoneal tumor spread in serous ovarian cancer-epithelial mesenchymal status and outcome.

Oncotarget

Auer K,Bachmayr-Heyda A,Aust S,Sukhbaatar N,Reiner AT,Grimm C,Horvat R,Zeillinger R,Pils D

25-0441 was used in Flow cytometry/Cell sorting to analyze the biological mechanisms underlying different modes of peritoneal tumor spread in serous ovarian cancer.

Fri Jul 10 00:00:00 EDT 2015

Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spatial learning and memory in mouse middle cerebral artery occlusion model.

Stem cell research & therapy

Zhou F,Gao S,Wang L,Sun C,Chen L,Yuan P,Zhao H,Yi Y,Qin Y,Dong Z,Cao L,Ren H,Zhu L,Li Q,Lu B,Liang A,Xu GT,Zhu H,Gao Z,Ma J,Xu J,Chen X

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Sat May 09 00:00:00 EDT 2015

CCR10 regulates balanced maintenance and function of resident regulatory and effector T cells to promote immune homeostasis in the skin.

The Journal of allergy and clinical immunology

Xia M,Hu S,Fu Y,Jin W,Yi Q,Matsui Y,Yang J,McDowell MA,Sarkar S,Kalia V,Xiong N

25-0441 was used in Flow cytometry/Cell sorting to investigate the functional importance of CCR10/CCL27 in vivo, showing that CCR10 regulates maintenance and function of regulatory and effector T cells to promote immune homeostasis.

Mon Sep 01 00:00:00 EDT 2014

Comparison of human adipose-derived stem cells isolated from subcutaneous, omental, and intrathoracic adipose tissue depots for regenerative applications.

Stem cells translational medicine

Russo V,Yu C,Belliveau P,Hamilton A,Flynn LE

25-0441 was used in Flow cytometry/Cell sorting to determine that depot selection is an important factor to consider when applying ASCs in tissue-specific cell-based regenerative therapies.

Sat Feb 01 00:00:00 EST 2014

An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells.

Journal of immunology (Baltimore, Md. : 1950)

White AJ,Jenkinson WE,Cowan JE,Parnell SM,Bacon A,Jones ND,Jenkinson EJ,Anderson G

25-0441 was used in Flow cytometry/Cell sorting to investigate whether thymus microenvironments are required in iNKT cell development, showing that medullary thymic epithelial cells are essential for intrathymic development of iNKT cells.

Sat Mar 15 00:00:00 EDT 2014

High-resolution molecular validation of self-renewal and spontaneous differentiation in clinical-grade adipose-tissue derived human mesenchymal stem cells.

Journal of cellular biochemistry

Dudakovic A,Camilleri E,Riester SM,Lewallen EA,Kvasha S,Chen X,Radel DJ,Anderson JM,Nair AA,Evans JM,Krych AJ,Smith J,Deyle DR,Stein JL,Stein GS,Im HJ,Cool SM,Westendorf JJ,Kakar S,Dietz AB,van Wijnen AJ

25-0441 was used in Flow cytometry/Cell sorting to characterise the expression of surface markers on adipose-tissue derived human mesenchymal stromal/stem cells.

Wed Oct 01 00:00:00 EDT 2014

Serum- and growth-factor-free three-dimensional culture system supports cartilage tissue formation by promoting collagen synthesis via Sox9-Col2a1 interaction.

Tissue engineering. Part A

Ahmed N,Iu J,Brown CE,Taylor DW,Kandel RA

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Aug 01 00:00:00 EDT 2014

Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.

PloS one

Beaufort CM,Helmijr JC,Piskorz AM,Hoogstraat M,Ruigrok-Ritstier K,Besselink N,Murtaza M,van Ĳcken WF,Heine AA,Smid M,Koudijs MJ,Brenton JD,Berns EM,Helleman J

25-0441 was used in Flow cytometry/Cell sorting to test for associations between the cellular and molecular features of ovarian cancer cell lines and clinical features of ovarian cancer.

Mon Jan 25 00:00:00 EST 2016

Autophagy is a critical regulator of memory CD8(+) T cell formation.

eLife

Puleston DJ,Zhang H,Powell TJ,Lipina E,Sims S,Panse I,Watson AS,Cerundolo V,Townsend AR,Klenerman P,Simon AK

25-0441 was used in Flow cytometry/Cell sorting to show that mice lacking the autophagy gene Atg7 in T cells failed to establish CD8(+) T cell memory to influenza and MCMV infection.

Tue Nov 11 00:00:00 EST 2014

Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation.

Neoplasia (New York, N.Y.)

Zhang S,Chung WC,Wu G,Egan SE,Xu K

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Sat Feb 01 00:00:00 EST 2014

FOXF1 mediates mesenchymal stem cell fusion-induced reprogramming of lung cancer cells.

Oncotarget

Wei HJ,Nickoloff JA,Chen WH,Liu HY,Lo WC,Chang YT,Yang PC,Wu CW,Williams DF,Gelovani JG,Deng WP

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Wed Oct 15 00:00:00 EDT 2014

Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.

PloS one

Xiao GY,Liu IH,Cheng CC,Chang CC,Lee YH,Cheng WT,Wu SC

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Thu May 28 00:00:00 EDT 2015

Validation of the effects of TGF-β1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical properties.

Cancer cell international

Wu TH,Chou YW,Chiu PH,Tang MJ,Hu CW,Yeh ML

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Mon Mar 03 00:00:00 EST 2014

Direct endothelial junction restoration results in significant tumor vascular normalization and metastasis inhibition in mice.

Oncotarget

Agrawal V,Maharjan S,Kim K,Kim NJ,Son J,Lee K,Choi HJ,Rho SS,Ahn S,Won MH,Ha SJ,Koh GY,Kim YM,Suh YG,Kwon YG

25-0441 was used in Flow cytometry/Cell sorting to examine the tumour vessel modulating activity of Sac-1004.

Thu May 15 00:00:00 EDT 2014

High-resolution analysis with novel cell-surface markers identifies routes to iPS cells.

Nature

O'Malley J,Skylaki S,Iwabuchi KA,Chantzoura E,Ruetz T,Johnsson A,Tomlinson SR,Linnarsson S,Kaji K

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Thu Jul 04 00:00:00 EDT 2013

miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.

Nature cell biology

Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2013

GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.

Nature cell biology

Chou J,Lin JH,Brenot A,Kim JW,Provot S,Werb Z

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2013

Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion.

Cancer research

Ferrari-Amorotti G,Fragliasso V,Esteki R,Prudente Z,Soliera AR,Cattelani S,Manzotti G,Grisendi G,Dominici M,Pieraccioli M,Raschellà G,Chiodoni C,Colombo MP,Calabretta B

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2013

Evidence for a multipotent mammary progenitor with pregnancy-specific activity.

Breast cancer research : BCR

Kaanta AS,Virtanen C,Selfors LM,Brugge JS,Neel BG

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Mon Dec 08 00:00:00 EST 2014

CD22 is required for protection against West Nile virus Infection.

Journal of virology

Ma DY,Suthar MS,Kasahara S,Gale M,Clark EA

25-0441 was used in Flow cytometry/Cell sorting to elucidate the immunological requirements for an antibody response following West Nile virus infection.

Fri Mar 01 00:00:00 EST 2013

The CD44+ ALDH+ population of human keratinocytes is enriched for epidermal stem cells with long-term repopulating ability.

Stem cells (Dayton, Ohio)

Szabo AZ,Fong S,Yue L,Zhang K,Strachan LR,Scalapino K,Mancianti ML,Ghadially R

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Mon Apr 01 00:00:00 EDT 2013

Estrogen and progesterone together expand murine endometrial epithelial progenitor cells.

Stem cells (Dayton, Ohio)

Janzen DM,Cheng D,Schafenacker AM,Paik DY,Goldstein AS,Witte ON,Jaroszewicz A,Pellegrini M,Memarzadeh S

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Mon Apr 01 00:00:00 EDT 2013

A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).

Disease models & mechanisms

Carofino BL,Ayanga B,Justice MJ

25-0441 was used in Flow cytometry/Cell sorting to demonstrate that increased expression of Prdm14 drives development of T-Cell acute lymphoblastic leukemia in mice.

Fri Nov 01 00:00:00 EDT 2013

Homeostatic proliferation of naive CD4+ T cells in mesenteric lymph nodes generates gut-tropic Th17 cells.

Journal of immunology (Baltimore, Md. : 1950)

Kawabe T,Sun SL,Fujita T,Yamaki S,Asao A,Takahashi T,So T,Ishii N

25-0441 was used in Flow cytometry/Cell sorting to evaluate organ-specific naive CD4(+) T cell proliferation and differentiation in the lymphoid and intestinal tissues of mice.

Sat Jun 01 00:00:00 EDT 2013

Distinct Roles for CXCR6(+) and CXCR6(-) CD4(+) T Cells in the Pathogenesis of Chronic Colitis.

PloS one

Mandai Y,Takahashi D,Hase K,Obata Y,Furusawa Y,Ebisawa M,Nakagawa T,Sato T,Katsuno T,Saito Y,Shimaoka T,Yokosuka O,Yokote K,Ohno H

25-0441 was used in Flow cytometry/Cell sorting to elucidate the different roles of CD4(+) T cell subsets in the development of inflammatory bowel disease.

Tue Oct 31 00:00:00 EDT 2017

Increased invasion and tumorigenicity capacity of CD44+/CD24- breast cancer MCF7 cells in vitro and in nude mice.

Cancer cell international

Yan W,Chen Y,Yao Y,Zhang H,Wang T

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Mon Jun 24 00:00:00 EDT 2013

Microvesicles derived from human umbilical cord Wharton's jelly mesenchymal stem cells attenuate bladder tumor cell growth in vitro and in vivo.

PloS one

Wu S,Ju GQ,Du T,Zhu YJ,Liu GH

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue Oct 22 00:00:00 EDT 2013

Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis.

Nature biotechnology

Getts DR,Martin AJ,McCarthy DP,Terry RL,Hunter ZN,Yap WT,Getts MT,Pleiss M,Luo X,King NJ,Shea LD,Miller SD

25-0441 was used in Flow cytometry/Cell sorting to highlight the potential for using microparticles to target natural apoptotic clearance pathways to inactivate pathogenic T cells in autoimmunity.

Sat Dec 01 00:00:00 EST 2012

The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.

Immunity

Hall AO,Beiting DP,Tato C,John B,Oldenhove G,Lombana CG,Pritchard GH,Silver JS,Bouladoux N,Stumhofer JS,Harris TH,Grainger J,Wojno ED,Wagage S,Roos DS,Scott P,Turka LA,Cherry S,Reiner SL,Cua D,Belkaid Y,Elloso MM,Hunter CA

25-0441 was used in Flow cytometry/Cell sorting to study the promotion of distinct Treg cell populations by the cytokines IL-27 and IFN-y, and the role they play in limiting infection induced pathology.

Fri Sep 21 00:00:00 EDT 2012

Fates of CD4+ T cells in a tolerant environment depend on timing and place of antigen exposure.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Burrell BE,Bromberg JS

25-0441 was used in Flow cytometry/Cell sorting to elucidate the key factors that determine the fate of graft reactive T cells.

Thu Mar 01 00:00:00 EST 2012

Increased protection from vaccinia virus infection in mice genetically prone to lymphoproliferative disorders.

Journal of virology

Seedhom MO,Mathurin KS,Kim SK,Welsh RM

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Jun 01 00:00:00 EDT 2012

Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation.

Stem cells (Dayton, Ohio)

Paik DY,Janzen DM,Schafenacker AM,Velasco VS,Shung MS,Cheng D,Huang J,Witte ON,Memarzadeh S

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Thu Nov 01 00:00:00 EDT 2012

The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering.

The Journal of biological chemistry

Yang C,Cao M,Liu H,He Y,Xu J,Du Y,Liu Y,Wang W,Cui L,Hu J,Gao F

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Dec 14 00:00:00 EST 2012

The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering.

The Journal of biological chemistry

Yang C,Cao M,Liu H,He Y,Xu J,Du Y,Liu Y,Wang W,Cui L,Hu J,Gao F

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Dec 14 00:00:00 EST 2012

IL-17-producing invariant NKT cells in lymphoid organs are recent thymic emigrants identified by neuropilin-1 expression.

Blood

Milpied P,Massot B,Renand A,Diem S,Herbelin A,Leite-de-Moraes M,Rubio MT,Hermine O

25-0441 was used in Flow cytometry/Cell sorting to determine the function of recent thymic emigrant invariant natural killer (RTE TiNKT) cells in naive mice.

Thu Sep 15 00:00:00 EDT 2011

The earliest intrathymic precursors of CD8α(+) thymic dendritic cells correspond to myeloid-type double-negative 1c cells.

European journal of immunology

Luche H,Ardouin L,Teo P,See P,Henri S,Merad M,Ginhoux F,Malissen B

25-0441 was used in Flow cytometry/Cell sorting to provide evidence that myeloid-restricted progenitors generate the whole constellation of DCs present in the body, including the thymus.

Mon Aug 01 00:00:00 EDT 2011

A role for IL-27 in limiting T regulatory cell populations.

Journal of immunology (Baltimore, Md. : 1950)

Wojno ED,Hosken N,Stumhofer JS,O'Hara AC,Mauldin E,Fang Q,Turka LA,Levin SD,Hunter CA

25-0441 was used in Flow cytometry/Cell sorting to show that mice that overexpress IL-27 had decreased Treg frequencies and developed spontaneous inflammation.

Fri Jul 01 00:00:00 EDT 2011

Critical appraisal of the side population assay in stem cell and cancer stem cell research.

Cell stem cell

Golebiewska A,Brons NH,Bjerkvig R,Niclou SP

25-0441 was used in Flow cytometry/Cell sorting to evaluate the use of the side population assay in stem cell and cancer stem cell research.

Fri Feb 04 00:00:00 EST 2011

GLI1 confers profound phenotypic changes upon LNCaP prostate cancer cells that include the acquisition of a hormone independent state.

PloS one

Nadendla SK,Hazan A,Ward M,Harper LJ,Moutasim K,Bianchi LS,Naase M,Ghali L,Thomas GJ,Prowse DM,Philpott MP,Neill GW

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Sep 30 00:00:00 EDT 2011

One naive T cell, multiple fates in CD8+ T cell differentiation.

The Journal of experimental medicine

Gerlach C,van Heijst JW,Swart E,Sie D,Armstrong N,Kerkhoven RM,Zehn D,Bevan MJ,Schepers K,Schumacher TN

25-0441 was used in Flow cytometry/Cell sorting to assess the potential for development of single naive T cells into different subsets.

Mon Jun 07 00:00:00 EDT 2010

Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells.

Journal of immunology (Baltimore, Md. : 1950)

Tait ED,Jordan KA,Dupont CD,Harris TH,Gregg B,Wilson EH,Pepper M,Dzierszinski F,Roos DS,Hunter CA

25-0441 was used in Flow cytometry/Cell sorting to show the dendritic cell response to T.gondii alters levels of CD8+ T cells which ultimately determine the outcome of infection.

Sun Aug 01 00:00:00 EDT 2010

High frequencies of virus-specific CD8+ T-cell precursors.

Journal of virology

Seedhom MO,Jellison ER,Daniels KA,Welsh RM

25-0441 was used in Flow cytometry/Cell sorting to examine CD8(+) T-cell precursor frequencies for whole viruses.

Tue Dec 01 00:00:00 EST 2009

Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice.

Journal of immunology (Baltimore, Md. : 1950)

Bianchi T,Pincus LB,Wurbel MA,Rich BE,Kupper TS,Fuhlbrigge RC,Boes M

25-0441 was used in Flow cytometry/Cell sorting to demonstrate that controlled skin homing of T-cells is critical for the maintenance of peripheral immune tolerance to epidermal self-Ags.

Wed Apr 15 00:00:00 EDT 2009

CXCR4 expression functionally discriminates centroblasts versus centrocytes within human germinal center B cells.

Journal of immunology (Baltimore, Md. : 1950)

Caron G,Le Gallou S,Lamy T,Tarte K,Fest T

25-0441 was used in Flow cytometry/Cell sorting to show that CXCR4 expression can properly separate human centroblasts from centrocytes and offer now the possibility to have purified normal counterparts of mature B cell-derived malignancies.

Mon Jun 15 00:00:00 EDT 2009

Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity.

Journal of immunology (Baltimore, Md. : 1950)

McKee AS,Munks MW,MacLeod MK,Fleenor CJ,Van Rooijen N,Kappler JW,Marrack P

25-0441 was used in Flow cytometry/Cell sorting to investigate how the body recognises alum, showing that it induces innate immune responses through macrophage and mast cell sensors.

Thu Oct 01 00:00:00 EDT 2009

Two host factors regulate persistence of H7-specific T cells injected in tumor-bearing mice.

PloS one

Meunier MC,Baron C,Perreault C

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Fri Feb 13 00:00:00 EST 2009

Effects of Culturing on the Stability of the Putative Murine Adipose Derived Stem Cells Markers.

The open stem cell journal

Maddox JR,Liao X,Li F,Niyibizi C

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2009

Immature hematopoietic cells display selective requirements for adhesion- and degranulation-promoting adaptor protein in development and homeostatsis.

European journal of immunology

Dluzniewska J,Zou L,Harmon IR,Ellingson MT,Peterson EJ

25-0441-82 was used in Flow Cytometry to highlight the dynamic regulation of ADAP during T cell maturation and document expression patterns that suggest a possible role for ADAP in development of non-T hematopoietic lineages.

Thu Nov 01 00:00:00 EDT 2007

Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection.

Infection and immunity

Anis MM,Fulton SA,Reba SM,Harding CV,Boom WH

Published figure using CD44 monoclonal antibody (Product # 25-0441-82) in Flow Cytometry

Tue May 01 00:00:00 EDT 2007

Bioinformatics

Protein Aliases: CD44; CD44 antigen; CD44 molecule; CDw44; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; ECMR-III; ECMRIII; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; hyaluronan receptor; Hyaluronate receptor; Ly-24; Lymphocyte antigen 24; PGP I; PGP-1; PGP-I; PGPI; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; sCD 44; sCD44; soluble CD 44; soluble CD44

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Gene Aliases: AU023126; AW121933; AW146109; CD44; CDW44; CSPG8; ECMR-III; HCELL; HERMES; HUTCH-I; IN; LHR; Ly-24; MC56; MDU2; MDU3; MIC4; Pgp-1; Pgp1

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UniProt ID: (Human) Q16064, (Mouse) P15379

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Entrez Gene ID: (Human) 960, (Mouse) 12505

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Function(s)

cytokine receptor activity protein binding collagen binding hyaluronic acid binding hyalurononglucosaminidase activity epidermal growth factor receptor binding protein kinase binding cytokine binding phosphoprotein binding transmembrane signal receptor

Process(es)

cell-matrix adhesion single organismal cell-cell adhesion extracellular matrix disassembly extracellular matrix organization hyaluronan catabolic process positive regulation of peptidyl-serine phosphorylation positive regulation of heterotypic cell-cell adhesion negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of DNA damage response, signal transduction by p53 class mediator cellular response to fibroblast growth factor stimulus positive regulation of peptidyl-tyrosine phosphorylation leukocyte migration cartilage development interferon-gamma-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade monocyte aggregation positive regulation of monocyte aggregation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of cell growth branching involved in ureteric bud morphogenesis wound healing involved in inflammatory response positive regulation of adaptive immune response negative regulation of mature B cell apoptotic process cell adhesion positive regulation of gene expression Wnt signaling pathway cell migration neuron projection development positive regulation of neutrophil apoptotic process macrophage fusion branching involved in prostate gland morphogenesis

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CD44 Monoclonal Antibody (IM7), PE-Cyanine7, eBioscience™

CD44 Antibody (25-0441-82) in Flow

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25-0441-82

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