Invitrogen

CD44 Monoclonal Antibody (IM7), Super Bright™ 780, eBioscience™

FIGURE: 1 / 96

CD44 Antibody (78-0441-80) in Flow

Staining of mouse splenocytes with with CD3e Monoclonal Antibody, APC (Product # 17-0031-82) and 0.25 µg of Rat IgG2b kappa Isotype Control, Super Bright 780 (Product # 78-4031-82) (left) or 0.25 µg of CD44 Monoclonal Antibody, Super Bright 780 (right). Total viable cells were used for analysis.

CD44 Antibody in Immunocytochemistry (ICC/IF)

CD44 Antibody in Immunocytochemistry, Flow Cytometry (ICC/IF, Flow)

CD44 Antibody in Immunohistochemistry (IHC)

Product Image Gallery

Product Details

78-0441-80

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 10 publications 10 publications

Immunocytochemistry (ICC/IF)

View 9 publications 9 publications

Flow Cytometry (Flow)

0.5 µg/test

View 94 publications 94 publications

Neutralization (Neu)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Not Applicable

Host/Isotype

Rat / IgG2b, kappa

Recommended Isotype Control

Rat IgG2b kappa Isotype Control (eB149/10H5), Super Bright™ 780, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

IM7

Conjugate

Super Bright™ 780 Super Bright™ 780 Super Bright™ 780

Excitation/Emission Max

413/780 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with BSA

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2722969

Product Specific Information

Description: The IM7 monoclonal antibody reacts with all isoforms of mouse CD44 (Pgp-1). CD44 is expressed by hematopoietic and non-hematopoietic cells. Bone marrow myeloid cells and memory T cells highly express this antigen and peripheral B and T cells can upregulate the expression of CD44. CD44 functions as an adhesion molecule through its binding to hyaluronate, an extracellular matrix component.

Applications Reported: This IM7 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This IM7 antibody has been tested by flow cytometric analysis of mouse bone marrow cells and splenocyte suspensions. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Super Bright 780 is a tandem dye that can be excited with the violet laser line (405 nm) and emits at 780 nm. We recommend using a 780/60 bandpass filter. Please make sure that your instrument is capable of detecting this fluorochrome.

When using two or more Super Bright dye-conjugated antibodies in a staining panel, it is recommended to use Super Bright Complete Staining Buffer (Product # SB-4401) to minimize any non-specific polymer interactions. Please refer to the datasheet for Super Bright Staining Buffer for more information.

In some experiments, we have observed that compensation values for Super Bright 780-conjugated antibodies are higher in the violet 450/50 channel when using UltraComp eBeads microspheres (Product # 01-2222-42) as compared to single-color stained cells. In such circumstances, we would recommend setting compensation with cells. We have also observed this in some experiments using AbC Total Antibody Compensation beads (Product # A10497).

Light sensitivity: This tandem dye is sensitive to photo-induced oxidation. Protect this vial and stained samples from light.

Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-8222) (100 µL of cell sample + 100 µL of IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product # 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.

Excitation: 405 nm; Emission: 780 nm; Laser: Violet Laser

Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company.

Target Information

CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

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Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

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Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

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Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.

Immunity

Bonavita E,Bromley CP,Jonsson G,Pelly VS,Sahoo S,Walwyn-Brown K,Mensurado S,Moeini A,Flanagan E,Bell CR,Chiang SC,Chikkanna-Gowda CP,Rogers N,Silva-Santos B,Jaillon S,Mantovani A,Reis e Sousa C,Guerra N,Davis DM,Zelenay S

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Tue Dec 15 00:00:00 EST 2020

Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4⁺ T Cell Pathogenicity and Suppresses Autoimmunity.

Cell metabolism

Angiari S,Runtsch MC,Sutton CE,Palsson-McDermott EM,Kelly B,Rana N,Kane H,Papadopoulou G,Pearce EL,Mills KHG,O'Neill LAJ

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Tue Feb 04 00:00:00 EST 2020

Transfer of metastatic traits via miR-200c in extracellular vesicles derived from colorectal cancer stem cells is inhibited by atractylenolide I.

Clinical and translational medicine

Tang D,Xu X,Ying J,Xie T,Cao G

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Sat Aug 01 00:00:00 EDT 2020

Cancer cells educate natural killer cells to a metastasis-promoting cell state.

The Journal of cell biology

Chan IS,Knútsdóttir H,Ramakrishnan G,Padmanaban V,Warrier M,Ramirez JC,Dunworth M,Zhang H,Jaffee EM,Bader JS,Ewald AJ

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Immunocytochemistry

Mon Sep 07 00:00:00 EDT 2020

Distinct roles of PIK3CA in the enrichment and maintenance of cancer stem cells in head and neck squamous cell carcinoma.

Molecular oncology

Chen X,Cao Y,Sedhom W,Lu L,Liu Y,Wang H,Oka M,Bornstein S,Said S,Song J,Lu SL

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

Down-Regulated Exosomal MicroRNA-221 - 3p Derived From Senescent Mesenchymal Stem Cells Impairs Heart Repair.

Frontiers in cell and developmental biology

Sun L,Zhu W,Zhao P,Zhang J,Lu Y,Zhu Y,Zhao W,Liu Y,Chen Q,Zhang F

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Dexamethasone inhibits stemness maintenance and enhances chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation of HIF‑1α and Oct4.

International journal of oncology

Jiang Z,Zhang C,Liu X,Ma X,Bian X,Xiao X,Gao R,Sun Y,Wu W,Zhao P

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2020

Extracellular HMGB-1 activates inflammatory signaling in tendon cells and tissues.

Therapeutic advances in chronic disease

Zhang C,Gu X,Zhao G,Wang W,Shao J,Zhu J,Yuan T,Sun J,Nie D,Zhou Y

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Sun Apr 17 00:00:00 EDT 2022

miR‑210 enhances mesenchymal stem cell‑modulated neural precursor cell migration.

Molecular medicine reports

Wang F,Zhu J,Zheng J,Duan W,Zhou Z

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2020

Identification, characterization and microRNA expression profiling of side population cells in human oral squamous cell carcinoma Tca8113 cell lines.

Molecular medicine reports

Luo W,Liu RS,E LL,Bai Y,Kong XP,Liu HW,Wu H,Liu HC

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2020

Resveratrol rescues TNF‑α‑induced inhibition of osteogenesis in human periodontal ligament stem cells via the ERK1/2 pathway.

Molecular medicine reports

Yuan J,Wang X,Ma D,Gao H,Zheng D,Zhang J

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Fri May 01 00:00:00 EDT 2020

Chronic expression of p16^INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation.

Nature communications

Azazmeh N,Assouline B,Winter E,Ruppo S,Nevo Y,Maly A,Meir K,Witkiewicz AK,Cohen J,Rizou SV,Pikarsky E,Luxenburg C,Gorgoulis VG,Ben-Porath I

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Immunohistochemistry

Mon Jun 01 00:00:00 EDT 2020

Critical role of WNK1 in MYC-dependent early mouse thymocyte development.

eLife

Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Wed Oct 14 00:00:00 EDT 2020

Effect of Combining Low Temperature Plasma, Negative Pressure Wound Therapy, and Bone Marrow Mesenchymal Stem Cells on an Acute Skin Wound Healing Mouse Model.

International journal of molecular sciences

Cui HS,Joo SY,Cho YS,Park JH,Kim JB,Seo CH

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Sat May 23 00:00:00 EDT 2020

Targeted expression profiling reveals distinct stages of early canine fibroblast reprogramming are regulated by 2-oxoglutarate hydroxylases.

Stem cell research & therapy

Tobias IC,Kao MC,Parmentier T,Hunter H,LaMarre J,Betts DH

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Immunocytochemistry

Wed Dec 09 00:00:00 EST 2020

Targeted expression profiling reveals distinct stages of early canine fibroblast reprogramming are regulated by 2-oxoglutarate hydroxylases.

Stem cell research & therapy

Tobias IC,Kao MC,Parmentier T,Hunter H,LaMarre J,Betts DH

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Immunocytochemistry

Wed Dec 09 00:00:00 EST 2020

Inhibition of EZH2 ameliorates bacteria-induced liver injury by repressing RUNX1 in dendritic cells.

Cell death & disease

Wang Y,Wang Q,Wang B,Gu Y,Yu H,Yang W,Ren X,Qian F,Zhao X,Xiao Y,Zhang Y,Jin M,Zhu M

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Diacerein treatment prevents colitis-associated cancer in mice.

World journal of clinical oncology

Paulino DSM,Mendes MCS,Camargo JA,Brambilla SR,Wood Dos Santos T,Ribeiro ML,Carvalheira JBC

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Immunohistochemistry

Thu Sep 24 00:00:00 EDT 2020

Graphene-based 2D constructs for enhanced fibroblast support.

PloS one

Safina I,Bourdo SE,Algazali KM,Kannarpady G,Watanabe F,Vang KB,Biris AS

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Immunocytochemistry

Tue Aug 04 00:00:00 EDT 2020

Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer.

Cancers

Witschen PM,Chaffee TS,Brady NJ,Huggins DN,Knutson TP,LaRue RS,Munro SA,Tiegs L,McCarthy JB,Nelson AC,Schwertfeger KL

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Fri May 22 00:00:00 EDT 2020

Head and Neck Cancer Stem Cell-Enriched Spheroid Model for Anticancer Compound Screening.

Cells

Goričan L,Gole B,Potočnik U

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Thu Jul 16 00:00:00 EDT 2020

Head and Neck Cancer Stem Cell-Enriched Spheroid Model for Anticancer Compound Screening.

Cells

Goričan L,Gole B,Potočnik U

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Thu Jul 16 00:00:00 EDT 2020

Profiling and Targeting of Energy and Redox Metabolism in Grade 2 Bladder Cancer Cells with Different Invasiveness Properties.

Cells

Pasquale V,Ducci G,Campioni G,Ventrici A,Assalini C,Busti S,Vanoni M,Vago R,Sacco E

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Fri Dec 11 00:00:00 EST 2020

Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals.

Cell & bioscience

Jiang M,Ye J,Wang X,Li N,Wang Y,Shi Y

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Thu Apr 14 00:00:00 EDT 2022

Requirements for the differentiation of innate T-bet^high memory-phenotype CD4⁺ T lymphocytes under steady state.

Nature communications

Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Mon Jul 06 00:00:00 EDT 2020

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.

Nature communications

Toubal A,Kiaf B,Beaudoin L,Cagninacci L,Rhimi M,Fruchet B,da Silva J,Corbett AJ,Simoni Y,Lantz O,Rossjohn J,McCluskey J,Lesnik P,Maguin E,Lehuen A

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Fri Jul 24 00:00:00 EDT 2020

Localized cocktail chemoimmunotherapy after in situ gelation to trigger robust systemic antitumor immune responses.

Science advances

Chao Y,Liang C,Tao H,Du Y,Wu D,Dong Z,Jin Q,Chen G,Xu J,Xiao Z,Chen Q,Wang C,Chen J,Liu Z

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2020

Utility Evaluation of Porcine Enteroids as PDCoV Infection Model in vitro.

Frontiers in microbiology

Luo H,Zheng J,Chen Y,Wang T,Zhang Z,Shan Y,Xu J,Yue M,Fang W,Li X

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Obesity-Altered Adipose Stem Cells Promote Radiation Resistance of Estrogen Receptor Positive Breast Cancer through Paracrine Signaling.

International journal of molecular sciences

Sabol RA,Villela VA,Denys A,Freeman BT,Hartono AB,Wise RM,Harrison MAA,Sandler MB,Hossain F,Miele L,Bunnell BA

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Wed Apr 15 00:00:00 EDT 2020

CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling.

Cell death & disease

Huang R,Wang S,Wang N,Zheng Y,Zhou J,Yang B,Wang X,Zhang J,Guo L,Wang S,Chen Z,Wang Z,Xiang S

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Thu Apr 16 00:00:00 EDT 2020

A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation.

Circulation research

Lu X,Rudemiller NP,Wen Y,Ren J,Hammer GE,Griffiths R,Privratsky JR,Yang B,Sparks MA,Crowley SD

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Fri Dec 06 00:00:00 EST 2019

Hypoxia changes chemotaxis behaviour of mesenchymal stem cells via HIF-1α signalling.

Journal of cellular and molecular medicine

Xu W,Xu R,Li Z,Wang Y,Hu R

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2019

The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway.

EBioMedicine

Seo D,Jung SM,Park JS,Lee J,Ha J,Kim M,Park SH

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Fri Nov 01 00:00:00 EDT 2019

Better therapeutic potential of bone marrow-derived mesenchymal stem cells compared with chorionic villi-derived mesenchymal stem cells in airway injury model.

Regenerative medicine

Ji S,Wu C,Tong L,Wang L,Zhou J,Chen C,Song Y

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2019

Overexpression of Aiolos promotes epithelial-mesenchymal transition and cancer stem cell-like properties in lung cancer cells.

Scientific reports

Hung JJ,Kao YS,Huang CH,Hsu WH

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Thu Feb 28 00:00:00 EST 2019

BMX-ARHGAP fusion protein maintains the tumorigenicity of gastric cancer stem cells by activating the JAK/STAT3 signaling pathway.

Cancer cell international

Xu XF,Gao F,Wang JJ,Long C,Chen X,Tao L,Yang L,Ding L,Ji Y

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Fri Apr 08 00:00:00 EDT 2022

Sex Differences in Mouse Popliteal Lymph Nodes.

Scientific reports

Dill-Garlow R,Chen KE,Walker AM

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Wed Jan 30 00:00:00 EST 2019

ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.

Nature communications

Cao Y,Trillo-Tinoco J,Sierra RA,Anadon C,Dai W,Mohamed E,Cen L,Costich TL,Magliocco A,Marchion D,Klar R,Michel S,Jaschinski F,Reich RR,Mehrotra S,Cubillos-Ruiz JR,Munn DH,Conejo-Garcia JR,Rodriguez PC

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Wed Mar 20 00:00:00 EDT 2019

BRCA1 regulates the cancer stem cell fate of breast cancer cells in the context of hypoxia and histone deacetylase inhibitors.

Scientific reports

Kim H,Lin Q,Yun Z

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Thu Jul 04 00:00:00 EDT 2019

Visfatin Mediates Malignant Behaviors through Adipose-Derived Stem Cells Intermediary in Breast Cancer.

Cancers

Huang JY,Wang YY,Lo S,Tseng LM,Chen DR,Wu YC,Hou MF,Yuan SF

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Fri Dec 20 00:00:00 EST 2019

Growth Factor Screening in Dystrophic Muscles Reveals PDGFB/PDGFRB-Mediated Migration of Interstitial Stem Cells.

International journal of molecular sciences

Camps J,Grosemans H,Gijsbers R,Maes C,Sampaolesi M

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Tue Mar 05 00:00:00 EST 2019

Bryostatin-1 alleviates experimental multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Tue Feb 27 00:00:00 EST 2018

Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.

Oncogene

Solomon H,Dinowitz N,Pateras IS,Cooks T,Shetzer Y,Molchadsky A,Charni M,Rabani S,Koifman G,Tarcic O,Porat Z,Kogan-Sakin I,Goldfinger N,Oren M,Harris CC,Gorgoulis VG,Rotter V

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Thu Mar 01 00:00:00 EST 2018

The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells.

Breast cancer research : BCR

Kim H,Lin Q,Glazer PM,Yun Z

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Tue Mar 06 00:00:00 EST 2018

SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer.

The Journal of cell biology

Viotti M,Wilson C,McCleland M,Koeppen H,Haley B,Jhunjhunwala S,Klijn C,Modrusan Z,Arnott D,Classon M,Stephan JP,Mellman I

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Mon Feb 05 00:00:00 EST 2018

Polymethoxylated Flavones from Orange Peels Inhibit Cell Proliferation in a 3D Cell Model of Human Colorectal Cancer.

Nutrition and cancer

Silva I,Estrada MF,V Pereira C,da Silva AB,Bronze MR,Alves PM,Duarte CMM,Brito C,Serra AT

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Immunocytochemistry

Wed Apr 03 00:00:00 EDT 2019

LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/β-catenin pathway and predicts poor survival of glioma patients.

Journal of experimental & clinical cancer research : CR

Zhang J,Cai H,Sun L,Zhan P,Chen M,Zhang F,Ran Y,Wan J

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Immunohistochemistry

Wed Sep 12 00:00:00 EDT 2018

mTOR Modulates CD8+ T Cell Differentiation in Mice with Invasive Pulmonary Aspergillosis.

Open life sciences

Wang H,Xiao Y,Su L,Cui N,Liu D

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Mon Jan 01 00:00:00 EST 2018

RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.

The Journal of biological chemistry

Ge J,Burnier L,Adamopoulou M,Kwa MQ,Schaks M,Rottner K,Brakebusch C

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Fri Jun 15 00:00:00 EDT 2018

A high-yield isolation and enrichment strategy for human lung microvascular endothelial cells.

Pulmonary circulation

Gaskill C,Majka SM

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

ST6GALNAC1 plays important roles in enhancing cancer stem phenotypes of colorectal cancer via the Akt pathway.

Oncotarget

Ogawa T,Hirohashi Y,Murai A,Nishidate T,Okita K,Wang L,Ikehara Y,Satoyoshi T,Usui A,Kubo T,Nakastugawa M,Kanaseki T,Tsukahara T,Kutomi G,Furuhata T,Hirata K,Sato N,Mizuguchi T,Takemasa I,Torigoe T

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Immunohistochemistry

Fri Dec 22 00:00:00 EST 2017

Equine-Induced Pluripotent Stem Cells Retain Lineage Commitment Toward Myogenic and Chondrogenic Fates.

Stem cell reports

Quattrocelli M,Giacomazzi G,Broeckx SY,Ceelen L,Bolca S,Spaas JH,Sampaolesi M

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Immunocytochemistry

Tue Jan 12 00:00:00 EST 2016

Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.

Cell transplantation

Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Mon Nov 16 00:00:00 EST 2015

Validation of the effects of TGF-β1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical properties.

Cancer cell international

Wu TH,Chou YW,Chiu PH,Tang MJ,Hu CW,Yeh ML

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Mon Mar 03 00:00:00 EST 2014

Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion.

Cancer research

Ferrari-Amorotti G,Fragliasso V,Esteki R,Prudente Z,Soliera AR,Cattelani S,Manzotti G,Grisendi G,Dominici M,Pieraccioli M,Raschellà G,Chiodoni C,Colombo MP,Calabretta B

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2013

The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering.

The Journal of biological chemistry

Yang C,Cao M,Liu H,He Y,Xu J,Du Y,Liu Y,Wang W,Cui L,Hu J,Gao F

Published figure using CD44 monoclonal antibody (Product # 78-0441-80) in Flow Cytometry

Fri Dec 14 00:00:00 EST 2012

Bioinformatics

Protein Aliases: CD44; CD44 antigen; CD44 molecule; CDw44; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; ECMR-III; ECMRIII; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; hyaluronan receptor; Hyaluronate receptor; Ly-24; Lymphocyte antigen 24; PGP I; PGP-1; PGP-I; PGPI; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; sCD 44; sCD44; soluble CD 44; soluble CD44

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Gene Aliases: AU023126; AW121933; AW146109; CD44; CDW44; CSPG8; ECMR-III; HCELL; HERMES; HUTCH-I; IN; LHR; Ly-24; MC56; MDU2; MDU3; MIC4; Pgp-1; Pgp1

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UniProt ID: (Human) Q16064, (Mouse) P15379

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Entrez Gene ID: (Human) 960, (Mouse) 12505

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Function(s)

cytokine receptor activity protein binding collagen binding hyaluronic acid binding hyalurononglucosaminidase activity epidermal growth factor receptor binding protein kinase binding cytokine binding phosphoprotein binding transmembrane signal receptor

Process(es)

cell-matrix adhesion single organismal cell-cell adhesion extracellular matrix disassembly extracellular matrix organization hyaluronan catabolic process positive regulation of peptidyl-serine phosphorylation positive regulation of heterotypic cell-cell adhesion negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of DNA damage response, signal transduction by p53 class mediator cellular response to fibroblast growth factor stimulus positive regulation of peptidyl-tyrosine phosphorylation leukocyte migration cartilage development interferon-gamma-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade monocyte aggregation positive regulation of monocyte aggregation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of cell growth branching involved in ureteric bud morphogenesis wound healing involved in inflammatory response positive regulation of adaptive immune response negative regulation of mature B cell apoptotic process cell adhesion positive regulation of gene expression Wnt signaling pathway cell migration neuron projection development positive regulation of neutrophil apoptotic process macrophage fusion branching involved in prostate gland morphogenesis

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CD44 Monoclonal Antibody (IM7), Super Bright™ 780, eBioscience™

CD44 Antibody (78-0441-80) in Flow

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78-0441-80

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