Invitrogen

CD44 Monoclonal Antibody (IM7), PE, eBioscience™

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

97 Published Figures

293 References

View all (259) CD44 antibodies

Datasheet

Protocols

Questions & Answers

Tech Support

Datasheet

Protocols

Questions & Answers

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FIGURE: 1 / 99

CD44 Antibody (12-0441-82) in Flow

Differential expression of Anti-Human/Mouse CD44 PE on mouse bone marrow cells. BALB/c bone marrow cells were stained with 0.06 µg of Anti-Human/Mouse CD44 PE. Total viable cells were gated further on their light scatter profile. The lymphoid lineage cells (R2) express Anti-Human/Mouse CD44 PE at an intermediate level, while the myeloid lineage cells (R3 & R4) display much higher levels of Anti-Human/Mouse CD44 PE surface expression. The overlay histogram on each panel (green) is the autofluorescence of cells.

Product Image Gallery

CD44 Antibody — Figure 3. CT targets LNCaP TICs. (A) FACS analysis was performed to determine the percentage of CD44+CD24- cells after treatment with increasing doses of CT (2.5, 5 and 10 uM). Data from a representative experiment (from a total of three) are shown. (B) Percentage of CD44 + CD24 - LNCaP cells compared to untreated control. The percentage reduced in a dose dependent manner, however no statistically significant difference was observed between the control and CT treated groups. (C) Sphere formation assay quantification was performed using increasing doses of CT. (D) The sphere forming ability was significantly inhibited by CT while the dose up to 1.5 uM, (*P<0.05; **P<0.01). (E) Sphere formation assay of CD44 + /CD24 - cells was performed using increasing doses of CT. (F) The sphere forming ability were inhibited by CT while the dose up to 0.625 uM (**P<0.05; *P<0.01). FACS, fluorescent activated cell sorting; CT, cryptotanshinone; TICs, tumor initiating cells. {TM}

Product Details

12-0441-82

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Flow Cytometry (Flow)

0.125 µg/test

View 290 publications 290 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Bovine, Fruit fly, Human, Mouse, Non-human primate, Rabbit, Rat

Host/Isotype

Rat / IgG2b, kappa

Recommended Isotype Control

Rat IgG2b kappa Isotype Control (eB149/10H5), PE, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

IM7

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_465664

Product Specific Information

Description: The IM7 monoclonal antibody reacts with all isoforms of mouse CD44 (Pgp-1). CD44 is expressed by hematopoietic and non-hematopoietic cells. Bone marrow myeloid cells and memory T cells highly express this antigen and peripheral B and T cells can upregulate the expression of CD44. CD44 functions as an adhesion molecule through its binding to hyaluronate, an extracellular matrix component.

Applications Reported: The IM7 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The IM7 antibody has been tested by flow cytometric analysis of mouse bone marrow cells and splenocytes. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

A platinum@polymer-catechol nanobraker enables radio-immunotherapy for crippling melanoma tumorigenesis, angiogenesis, and radioresistance.

Bioactive materials

Li W,Yan J,Tian H,Li B,Wang G,Sang W,Zhang Z,Zhang X,Dai Y

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2023

Exercise combined with administration of adipose-derived stem cells ameliorates neuropathic pain after spinal cord injury.

Neural regeneration research

Cheng X,Mao GP,Hu WJ,Yu ZR,Xu YY,Chen W,Li X,Zeng XL,Zhang WW,Chen JW,Wan Y,Wang L

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

Obesity impairs cardiolipin-dependent mitophagy and therapeutic intercellular mitochondrial transfer ability of mesenchymal stem cells.

Cell death & disease

Sagar S,Faizan MI,Chaudhary N,Singh V,Singh P,Gheware A,Sharma K,Azmi I,Singh VP,Kharya G,Mabalirajan U,Agrawal A,Ahmad T,Sinha Roy S

12-0441-82 was used in Flow cytometry/Cell sorting to provide the first comprehensive molecular understanding of impaired mitophagy in obese-derived MSCs and highlight the importance of pharmacological modulation of these cells for therapeutic intervention.

Sat May 13 00:00:00 EDT 2023

TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.

Frontiers in immunology

O'Neill TJ,Gewies A,Seeholzer T,Krappmann D

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Feb 13 00:00:00 EST 2023

Stabilization of E-cadherin adhesions by COX-2/GSK3β signaling is a targetable pathway in metastatic breast cancer.

JCI insight

Balamurugan K,Poria DK,Sehareen SW,Krishnamurthy S,Tang W,McKennett L,Padmanaban V,Czarra K,Ewald AJ,Ueno NT,Ambs S,Sharan S,Sterneck E

12-0441-82 was used in Flow cytometry/Cell sorting to uncover a mechanism by which metastatic breast cancer cells can maintain E-cadherin-mediated cell-cell adhesions and cell survival, suggesting that some patients with COX-2+/E-cadherin+ breast cancer may benefit from targeting of the PGE2 signaling pathway.

Wed Mar 22 00:00:00 EDT 2023

R274X-mutated Phf6 increased the self-renewal and skewed T cell differentiation of hematopoietic stem cells.

iScience

Lan Y,Yuan S,Guo T,Hou S,Zhao F,Yang W,Cao Y,Chu Y,Jiang E,Yuan W,Wang X

12-0441-82 was used in Flow cytometry/Cell sorting to demonstrate that Phf6R274X plays a critical role in fine-tuning T cells and HSC homeostasis.

Fri Jun 16 00:00:00 EDT 2023

Natural γδT17 cell development and functional acquisition is governed by the mTORC2-c-Maf-controlled mitochondrial fission pathway.

iScience

Wang Y,Qin H,Cai Y,Chen X,Li H,Montoya-Durango DE,Ding C,Hu X,Chariker JH,Sarojini H,Chien S,Rouchka EC,Zhang HG,Zheng J,Qiu F,Yan J

12-0441-82 was used in Flow cytometry/Cell sorting to provide an in-depth insight into the intrinsic link between the mitochondrial OXPHOS pathway and γδT17 thymic programming and functional acquisition.

Fri May 19 00:00:00 EDT 2023

CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.

The Journal of clinical investigation

Sato Y,Oguchi A,Fukushima Y,Masuda K,Toriu N,Taniguchi K,Yoshikawa T,Cui X,Kondo M,Hosoi T,Komidori S,Shimizu Y,Fujita H,Jiang L,Kong Y,Yamanashi T,Seita J,Yamamoto T,Toyokuni S,Hamazaki Y,Hattori M,Yoshikai Y,Boor P,Floege J,Kawamoto H,Murakawa Y,Minato N,Yanagita M

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Jan 18 00:00:00 EST 2022

FUS-DDIT3 Fusion Oncoprotein Expression Affects JAK-STAT Signaling in Myxoid Liposarcoma.

Frontiers in oncology

Dolatabadi S,Jonasson E,Andersson L,Luna Santamaría M,Lindén M,Österlund T,Åman P,Ståhlberg A

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Feb 23 00:00:00 EST 2022

LncRNA ANRIL-mediated miR-181b-5p/S1PR1 axis is involved in the progression of uremic cardiomyopathy through activating T cells.

Scientific reports

Xu Y,Cao L,Ji S,Shen W

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Oct 27 00:00:00 EDT 2022

Isolation and characterization mesenchymal stem cells from red panda (Ailurus fulgens styani) endometrium.

Conservation physiology

Wang DH,Wu XM,Chen JS,Cai ZG,An JH,Zhang MY,Li Y,Li FP,Hou R,Liu YL

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Sat Jan 01 00:00:00 EST 2022

WDR82-binding long noncoding RNA lncEry controls mouse erythroid differentiation and maturation.

The Journal of experimental medicine

Yang S,Sun G,Wu P,Chen C,Kuang Y,Liu L,Zheng Z,He Y,Gu Q,Lu T,Zhu C,Wang F,Gou F,Yang Z,Zhao X,Yuan S,Yang L,Lu S,Li Y,Lv X,Dong F,Ma Y,Yu J,Ng LG,Shi L,Liu J,Shi L,Cheng T,Cheng H

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Apr 04 00:00:00 EDT 2022

Multivalent state transitions shape the intratumoral composition of small cell lung carcinoma.

Science advances

Gopal P,Petty A,Rogacki K,Bera T,Bareja R,Peacock CD,Abazeed ME

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Dec 14 00:00:00 EST 2022

Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression.

Nature communications

Qi M,Xia Y,Wu Y,Zhang Z,Wang X,Lu L,Dai C,Song Y,Xu K,Ji W,Zhan L

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Feb 16 00:00:00 EST 2022

RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.

Cell death & disease

Novak R,Ahmad YA,Timaner M,Bitman-Lotan E,Oknin-Vaisman A,Horwitz R,Hartmann O,Reissland M,Buck V,Rosenfeldt M,Nikomarov D,Diefenbacher ME,Shaked Y,Orian A

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Sat Sep 24 00:00:00 EDT 2022

CD44 Promotes Breast Cancer Metastasis through AKT-Mediated Downregulation of Nuclear FOXA2.

Biomedicines

Vadhan A,Hou MF,Vijayaraghavan P,Wu YC,Hu SC,Wang YM,Cheng TL,Wang YY,Yuan SF

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Oct 05 00:00:00 EDT 2022

Circ_RNF13 Regulates the Stemness and Chemosensitivity of Colorectal Cancer by Transcriptional Regulation of DDX27 Mediated by TRIM24 Stabilization.

Cancers

Guo Y,Hu G,Tian B,Ma M,Long F,Chen M

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Dec 16 00:00:00 EST 2022

Smad4 and p53 synergize in suppressing autochthonous intestinal cancer.

Cancer medicine

Park JW,Seo MJ,Cho KS,Kook MC,Jeong JM,Roh SG,Cho SY,Cheon JH,Kim HK

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2022

Amphiphile-CpG vaccination induces potent lymph node activation and COVID-19 immunity in mice and non-human primates.

NPJ vaccines

Seenappa LM,Jakubowski A,Steinbuck MP,Palmer E,Haqq CM,Carter C,Fontenot J,Villinger F,McNeil LK,DeMuth PC

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Oct 28 00:00:00 EDT 2022

NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.

Nature immunology

Gu M,Zhou X,Sohn JH,Zhu L,Jie Z,Yang JY,Zheng X,Xie X,Yang J,Shi Y,Brightbill HD,Kim JB,Wang J,Cheng X,Sun SC

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Disruption of the MSL complex inhibits tumour maintenance by exacerbating chromosomal instability.

Nature cell biology

Monserrat J,Morales Torres C,Richardson L,Wilson TS,Patel H,Domart MC,Horswell S,Song OR,Jiang M,Crawford M,Bui M,Dalal Y,Scaffidi P

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Apr 01 00:00:00 EDT 2021

A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza.

The Journal of experimental medicine

Rappe JCF,Finsterbusch K,Crotta S,Mack M,Priestnall SL,Wack A

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Nov 01 00:00:00 EDT 2021

Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.

The Journal of experimental medicine

Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Aug 02 00:00:00 EDT 2021

Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells.

The Journal of experimental medicine

Hosokawa H,Koizumi M,Masuhara K,Romero-Wolf M,Tanaka T,Nakayama T,Rothenberg EV

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Aug 02 00:00:00 EDT 2021

Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccination.

EMBO molecular medicine

Müller K,Gibbins MP,Roberts M,Reyes-Sandoval A,Hill AVS,Draper SJ,Matuschewski K,Silvie O,Hafalla JCR

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Apr 09 00:00:00 EDT 2021

Senescent T Cell Induces Brown Adipose Tissue "Whitening" Via Secreting IFN-γ.

Frontiers in cell and developmental biology

Pan XX,Yao KL,Yang YF,Ge Q,Zhang R,Gao PJ,Ruan CC,Wu F

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Mar 23 00:00:00 EDT 2021

Trichinella spiralis Paramyosin Induces Colonic Regulatory T Cells to Mitigate Inflammatory Bowel Disease.

Frontiers in cell and developmental biology

Hao C,Wang W,Zhan B,Wang Z,Huang J,Sun X,Zhu X

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Aug 03 00:00:00 EDT 2021

Downregulation of SLC27A6 by DNA Hypermethylation Promotes Proliferation but Suppresses Metastasis of Nasopharyngeal Carcinoma Through Modulating Lipid Metabolism.

Frontiers in oncology

Zhong X,Yang Y,Li B,Liang P,Huang Y,Zheng Q,Wang Y,Xiao X,Mo Y,Zhang Z,Zhou X,Huang G,Zhao W

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Jan 21 00:00:00 EST 2022

Downregulation of SLC27A6 by DNA Hypermethylation Promotes Proliferation but Suppresses Metastasis of Nasopharyngeal Carcinoma Through Modulating Lipid Metabolism.

Frontiers in oncology

Zhong X,Yang Y,Li B,Liang P,Huang Y,Zheng Q,Wang Y,Xiao X,Mo Y,Zhang Z,Zhou X,Huang G,Zhao W

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Jan 21 00:00:00 EST 2022

Thrombospondin-2 spatiotemporal expression in skeletal fractures.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Zondervan RL,Jenkins DC,Reicha JD,Hankenson KD

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2021

Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy.

Frontiers in immunology

Agalave NM,Mody PH,Szabo-Pardi TA,Jeong HS,Burton MD

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Sep 20 00:00:00 EDT 2021

Prophylactic efficacy against Mycobacterium tuberculosis using ID93 and lipid-based adjuvant formulations in the mouse model.

PloS one

Baldwin SL,Reese VA,Larsen SE,Beebe E,Guderian J,Orr MT,Fox CB,Reed SG,Coler RN

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Oct 13 00:00:00 EDT 2021

In Vitro Anti-cancer Activity of Adipose-Derived Mesenchymal Stem Cells Increased after Infection with Oncolytic Reovirus.

Advanced pharmaceutical bulletin

Babaei A,Bannazadeh Baghi H,Nezhadi A,Jamalpoor Z

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Valproic acid stimulates myogenesis in pluripotent stem cell-derived mesodermal progenitors in a NOTCH-dependent manner.

Cell death & disease

Breuls N,Giarratana N,Yedigaryan L,Garrido GM,Carai P,Heymans S,Ranga A,Deroose C,Sampaolesi M

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Jul 05 00:00:00 EDT 2021

miR-34a mimic or pre-mir-34a, which is the better option for cancer therapy? KatoIII as a model to study miRNA action in human gastric cancer cells.

Cancer cell international

Jafari N,Abediankenari S,Hossein-Nataj H

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Mar 19 00:00:00 EDT 2021

PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8⁺ T cells at the expense of central memory.

Cell reports

Cannons JL,Villarino AV,Kapnick SM,Preite S,Shih HY,Gomez-Rodriguez J,Kaul Z,Shibata H,Reilley JM,Huang B,Handon R,McBain IT,Gossa S,Wu T,Su HC,McGavern DB,O'Shea JJ,McGuire PJ,Uzel G,Schwartzberg PL

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Oct 12 00:00:00 EDT 2021

MiR-125b-5p Is Involved in Sorafenib Resistance through Ataxin-1-Mediated Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma.

Cancers

Hirao A,Sato Y,Tanaka H,Nishida K,Tomonari T,Hirata M,Bando M,Kida Y,Tanaka T,Kawaguchi T,Wada H,Taniguchi T,Okamoto K,Miyamoto H,Muguruma N,Tanahashi T,Takayama T

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression.

iScience

AbuEid M,McAllister DM,McOlash L,Harwig MC,Cheng G,Drouillard D,Boyle KA,Hardy M,Zielonka J,Johnson BD,Hill RB,Kalyanaraman B,Dwinell MB

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Jun 25 00:00:00 EDT 2021

Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis.

Nature communications

Li H,Wang M,Huang B,Zhu SW,Zhou JJ,Chen DR,Cui R,Zhang M,Sun ZJ

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Dec 09 00:00:00 EST 2021

Therapeutic Potential of Mesenchymal Stem Cells in a Pre-Clinical Model of Diabetic Kidney Disease and Obesity.

International journal of molecular sciences

Sávio-Silva C,Soinski-Sousa PE,Simplício-Filho A,Bastos RMC,Beyerstedt S,Rangel ÉB

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Feb 04 00:00:00 EST 2021

Attenuation of apoptotic cell detection triggers thymic regeneration after damage.

Cell reports

Kinsella S,Evandy CA,Cooper K,Iovino L,deRoos PC,Hopwo KS,Granadier DW,Smith CW,Rafii S,Dudakov JA

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Oct 05 00:00:00 EDT 2021

Protocols for isolation and characterization of mouse placental hemogenic endothelial cells.

STAR protocols

Liang G,Huang B,Wang F,Liu F

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Dec 17 00:00:00 EST 2021

Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.

EBioMedicine

Okada R,Furusawa A,Vermeer DW,Inagaki F,Wakiyama H,Kato T,Nagaya T,Choyke PL,Spanos WC,Allen CT,Kobayashi H

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

3-hydroxyanthranic acid increases the sensitivity of hepatocellular carcinoma to sorafenib by decreasing tumor cell stemness.

Cell death discovery

Gan G,Shi Z,Liu D,Zhang S,Zhu H,Wang Y,Mi J

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Jul 06 00:00:00 EDT 2021

A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Yu S,Lu Y,Su A,Chen J,Li J,Zhou B,Liu X,Xia Q,Li Y,Li J,Huang M,Ye Y,Zhao Q,Jiang S,Yan X,Wang X,Di C,Pan J,Su S

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Oct 01 00:00:00 EDT 2021

Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid.

The Journal of biological chemistry

Zhao Y,Cheng R,Zhao Y,Ge W,Yang Y,Ding Z,Xu X,Wang Z,Wu Z,Zhang J

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Oct 01 00:00:00 EDT 2021

A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.

Nature communications

Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure.

Cell death & disease

Yu H,Yang W,Huang J,Miao X,Wang B,Ren X,Gu Y,Wang Q,Ding X,Guo X,Qian F,Zhang Y,Xu H,Zheng L,Jin M

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Dec 16 00:00:00 EST 2021

Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.

Frontiers in immunology

Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Jan 11 00:00:00 EST 2022

Differential activation of Ca²⁺ influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration.

NPJ Regenerative medicine

Ahamad N,Sun Y,Nascimento Da Conceicao V,Xavier Paul Ezhilan CRD,Natarajan M,Singh BB

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Immunohistochemistry

Wed Oct 20 00:00:00 EDT 2021

Differential activation of Ca²⁺ influx channels modulate stem cell potency, their proliferation/viability and tissue regeneration.

NPJ Regenerative medicine

Ahamad N,Sun Y,Nascimento Da Conceicao V,Xavier Paul Ezhilan CRD,Natarajan M,Singh BB

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Immunohistochemistry

Wed Oct 20 00:00:00 EDT 2021

Derivation and Characterization of EGFP-Labeled Rabbit Limbal Mesenchymal Stem Cells and Their Potential for Research in Regenerative Ophthalmology.

Biomedicines

Khorolskaya JI,Perepletchikova DA,Kachkin DV,Zhurenkov KE,Alexander-Sinkler EI,Ivanova JS,Mikhailova NA,Blinova MI

12-0441-82 was used in Flow cytometry/Cell sorting to show that L-MSCs-EGFP may become a useful tool for studying regenerative processes occurring during the treatment of various corneal pathologies, including LSCD, with the use of cell-based technologies.

Wed Sep 01 00:00:00 EDT 2021

Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis.

Cell reports

Nanou A,Bourbouli M,Vetrano S,Schaeper U,Ley S,Kollias G

12-0441-82 was used in Flow Cytometry to investigate in vivo the role of Tumor progression locus 2 (Tpl2), a mitogen-activated protein kinase kinase kinase (MAP3K) member with pleiotropic effects in inflammation and cancer.

Tue May 25 00:00:00 EDT 2021

Increasing cytosolic Ca²⁺ levels restore cell proliferation and stem cell potency in aged MSCs.

Stem cell research

Ahamad N,Sun Y,Singh BB

12-0441-82 was used in Cell Culture to suggest that Ca2+ entry is essential for preventing the loss of aged stem cell function and supplementing Ca2+ not only restored their proliferative potential but, allowed them to develop into younger stem cell lineages that could be critical for regenerative medicine.

Fri Oct 01 00:00:00 EDT 2021

Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.

STAR protocols

Skordos I,Demeyer A,Beyaert R

12-0441-82 was used in Flow Cytometry to provide a protocol for analysis of T cell activation and cytokine production in the thymus, spleen, and blood.

Fri Mar 19 00:00:00 EDT 2021

Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.

STAR protocols

Skordos I,Demeyer A,Beyaert R

12-0441-82 was used in Flow Cytometry to provide a protocol for analysis of T cell activation and cytokine production in the thymus, spleen, and blood.

Fri Mar 19 00:00:00 EDT 2021

Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Sang W,Xie L,Wang G,Li J,Zhang Z,Li B,Guo S,Deng CX,Dai Y

12-0441 was used in Flow cytometry/Cell sorting to presents a multifunctional metal-phenolic nanoplatform for efficient X-ray mediated RT-RDT in combination with immunotherapy and may provide a new therapeutic option for cancer treatment.

Mon Feb 01 00:00:00 EST 2021

Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.

Immunity

Bonavita E,Bromley CP,Jonsson G,Pelly VS,Sahoo S,Walwyn-Brown K,Mensurado S,Moeini A,Flanagan E,Bell CR,Chiang SC,Chikkanna-Gowda CP,Rogers N,Silva-Santos B,Jaillon S,Mantovani A,Reis e Sousa C,Guerra N,Davis DM,Zelenay S

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Dec 15 00:00:00 EST 2020

Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.

Immunity

Lou F,Sun Y,Xu Z,Niu L,Wang Z,Deng S,Liu Z,Zhou H,Bai J,Yin Q,Cai X,Sun L,Wang H,Li Q,Wu Z,Chen X,Gu J,Shi YL,Tao W,Ginhoux F,Wang H

12-0441-82 was used in Flow Cytometry to suggest that urea cycle hyperreactivity and excessive polyamine generation in psoriatic keratinocytes promote self-RNA sensation and PP6 deregulation in keratinocytes is a pivotal event that amplifies the inflammatory circuits in psoriasis.

Tue Jul 14 00:00:00 EDT 2020

Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4⁺ T Cell Pathogenicity and Suppresses Autoimmunity.

Cell metabolism

Angiari S,Runtsch MC,Sutton CE,Palsson-McDermott EM,Kelly B,Rana N,Kane H,Papadopoulou G,Pearce EL,Mills KHG,O'Neill LAJ

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Feb 04 00:00:00 EST 2020

Transfer of metastatic traits via miR-200c in extracellular vesicles derived from colorectal cancer stem cells is inhibited by atractylenolide I.

Clinical and translational medicine

Tang D,Xu X,Ying J,Xie T,Cao G

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Sat Aug 01 00:00:00 EDT 2020

Distinct roles of PIK3CA in the enrichment and maintenance of cancer stem cells in head and neck squamous cell carcinoma.

Molecular oncology

Chen X,Cao Y,Sedhom W,Lu L,Liu Y,Wang H,Oka M,Bornstein S,Said S,Song J,Lu SL

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

Down-Regulated Exosomal MicroRNA-221 - 3p Derived From Senescent Mesenchymal Stem Cells Impairs Heart Repair.

Frontiers in cell and developmental biology

Sun L,Zhu W,Zhao P,Zhang J,Lu Y,Zhu Y,Zhao W,Liu Y,Chen Q,Zhang F

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Inflammatory Cytokines Alter Mesenchymal Stem Cell Mechanosensing and Adhesion on Stiffened Infarct Heart Tissue After Myocardial Infarction.

Frontiers in cell and developmental biology

Zhu D,Wu P,Xiao C,Hu W,Zhang T,Hu X,Chen W,Wang J

12-0441 was used in Flow cytometry/Cell sorting to provide new mechanistic insights of mechanical-inflammation coupling to improve MSC mechanosensing and adhesion.

Tue Nov 17 00:00:00 EST 2020

Dexamethasone inhibits stemness maintenance and enhances chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation of HIF‑1α and Oct4.

International journal of oncology

Jiang Z,Zhang C,Liu X,Ma X,Bian X,Xiao X,Gao R,Sun Y,Wu W,Zhao P

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2020

Extracellular HMGB-1 activates inflammatory signaling in tendon cells and tissues.

Therapeutic advances in chronic disease

Zhang C,Gu X,Zhao G,Wang W,Shao J,Zhu J,Yuan T,Sun J,Nie D,Zhou Y

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Sun Apr 17 00:00:00 EDT 2022

miR‑210 enhances mesenchymal stem cell‑modulated neural precursor cell migration.

Molecular medicine reports

Wang F,Zhu J,Zheng J,Duan W,Zhou Z

12-0441 was used in Flow cytometry/Cell sorting to study the effects of bone marrow-derived mesenchymal stem cells (BMSCs) on neural precursor cell (NPC) migration.

Mon Jun 01 00:00:00 EDT 2020

miR‑210 enhances mesenchymal stem cell‑modulated neural precursor cell migration.

Molecular medicine reports

Wang F,Zhu J,Zheng J,Duan W,Zhou Z

12-0441 was used in Flow cytometry/Cell sorting to study the effects of bone marrow-derived mesenchymal stem cells (BMSCs) on neural precursor cell (NPC) migration.

Mon Jun 01 00:00:00 EDT 2020

Identification, characterization and microRNA expression profiling of side population cells in human oral squamous cell carcinoma Tca8113 cell lines.

Molecular medicine reports

Luo W,Liu RS,E LL,Bai Y,Kong XP,Liu HW,Wu H,Liu HC

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2020

Resveratrol rescues TNF‑α‑induced inhibition of osteogenesis in human periodontal ligament stem cells via the ERK1/2 pathway.

Molecular medicine reports

Yuan J,Wang X,Ma D,Gao H,Zheng D,Zhang J

12-0441-82 was used in Flow cytometry/Cell sorting to investigate the effect of tumor necrosis factor‚α, resveratrol, or the combination of both on the osteogenic differentiation of hPDLSCs, as well as the underlying mechanisms involved.

Fri May 01 00:00:00 EDT 2020

Resveratrol rescues TNF‑α‑induced inhibition of osteogenesis in human periodontal ligament stem cells via the ERK1/2 pathway.

Molecular medicine reports

Yuan J,Wang X,Ma D,Gao H,Zheng D,Zhang J

Fri May 01 00:00:00 EDT 2020

Critical role of WNK1 in MYC-dependent early mouse thymocyte development.

eLife

Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL

12-0441 was used in Flow cytometry/Cell sorting to ind that WNK1 is required for the transition of double negative (DN) thymocytes through the β-selection checkpoint and subsequent proliferation and differentiation into double positive (DP) thymocytes.

Wed Oct 14 00:00:00 EDT 2020

Critical role of WNK1 in MYC-dependent early mouse thymocyte development.

eLife

Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL

Wed Oct 14 00:00:00 EDT 2020

Effect of Combining Low Temperature Plasma, Negative Pressure Wound Therapy, and Bone Marrow Mesenchymal Stem Cells on an Acute Skin Wound Healing Mouse Model.

International journal of molecular sciences

Cui HS,Joo SY,Cho YS,Park JH,Kim JB,Seo CH

12-0441 was used in Flow cytometry/Cell sorting to show combination therapy with LPT, NPWT, and MSC may be a promising strategy for treatment of acute wounds.

Sat May 23 00:00:00 EDT 2020

Effect of Combining Low Temperature Plasma, Negative Pressure Wound Therapy, and Bone Marrow Mesenchymal Stem Cells on an Acute Skin Wound Healing Mouse Model.

International journal of molecular sciences

Cui HS,Joo SY,Cho YS,Park JH,Kim JB,Seo CH

12-0441 was used in Flow cytometry/Cell sorting to show combination therapy with LPT, NPWT, and MSC may be a promising strategy for treatment of acute wounds.

Sat May 23 00:00:00 EDT 2020

Targeted expression profiling reveals distinct stages of early canine fibroblast reprogramming are regulated by 2-oxoglutarate hydroxylases.

Stem cell research & therapy

Tobias IC,Kao MC,Parmentier T,Hunter H,LaMarre J,Betts DH

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Dec 09 00:00:00 EST 2020

Chemotherapeutic Stress Influences Epithelial-Mesenchymal Transition and Stemness in Cancer Stem Cells of Triple-Negative Breast Cancer.

International journal of molecular sciences

Li X,Strietz J,Bleilevens A,Stickeler E,Maurer J

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Jan 08 00:00:00 EST 2020

Inhibition of EZH2 ameliorates bacteria-induced liver injury by repressing RUNX1 in dendritic cells.

Cell death & disease

Wang Y,Wang Q,Wang B,Gu Y,Yu H,Yang W,Ren X,Qian F,Zhao X,Xiao Y,Zhang Y,Jin M,Zhu M

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Inhibition of EZH2 ameliorates bacteria-induced liver injury by repressing RUNX1 in dendritic cells.

Cell death & disease

Wang Y,Wang Q,Wang B,Gu Y,Yu H,Yang W,Ren X,Qian F,Zhao X,Xiao Y,Zhang Y,Jin M,Zhu M

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Neurokinin-1 Receptor Signaling Is Required for Efficient Ca²⁺ Flux in T-Cell-Receptor-Activated T Cells.

Cell reports

Morelli AE,Sumpter TL,Rojas-Canales DM,Bandyopadhyay M,Chen Z,Tkacheva O,Shufesky WJ,Wallace CT,Watkins SC,Berger A,Paige CJ,Falo LD,Larregina AT

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Mar 10 00:00:00 EDT 2020

Neurokinin-1 Receptor Signaling Is Required for Efficient Ca²⁺ Flux in T-Cell-Receptor-Activated T Cells.

Cell reports

Morelli AE,Sumpter TL,Rojas-Canales DM,Bandyopadhyay M,Chen Z,Tkacheva O,Shufesky WJ,Wallace CT,Watkins SC,Berger A,Paige CJ,Falo LD,Larregina AT

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Mar 10 00:00:00 EDT 2020

Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer.

Cancers

Witschen PM,Chaffee TS,Brady NJ,Huggins DN,Knutson TP,LaRue RS,Munro SA,Tiegs L,McCarthy JB,Nelson AC,Schwertfeger KL

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri May 22 00:00:00 EDT 2020

Utility Evaluation of Porcine Enteroids as PDCoV Infection Model in vitro.

Frontiers in microbiology

Luo H,Zheng J,Chen Y,Wang T,Zhang Z,Shan Y,Xu J,Yue M,Fang W,Li X

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Head and Neck Cancer Stem Cell-Enriched Spheroid Model for Anticancer Compound Screening.

Cells

Goričan L,Gole B,Potočnik U

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Jul 16 00:00:00 EDT 2020

Obesity-Altered Adipose Stem Cells Promote Radiation Resistance of Estrogen Receptor Positive Breast Cancer through Paracrine Signaling.

International journal of molecular sciences

Sabol RA,Villela VA,Denys A,Freeman BT,Hartono AB,Wise RM,Harrison MAA,Sandler MB,Hossain F,Miele L,Bunnell BA

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Apr 15 00:00:00 EDT 2020

Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.

Cell reports

Blagih J,Zani F,Chakravarty P,Hennequart M,Pilley S,Hobor S,Hock AK,Walton JB,Morton JP,Gronroos E,Mason S,Yang M,McNeish I,Swanton C,Blyth K,Vousden KH

12-0441 was used in Flow cytometry/Cell sorting to show suppressive regulatory T cells accumulate in tumour cells in the absence of p53 indicating a pathway in which cancer cells circumvent immune destruction.

Tue Jan 14 00:00:00 EST 2020

Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.

Cell reports

Blagih J,Zani F,Chakravarty P,Hennequart M,Pilley S,Hobor S,Hock AK,Walton JB,Morton JP,Gronroos E,Mason S,Yang M,McNeish I,Swanton C,Blyth K,Vousden KH

Tue Jan 14 00:00:00 EST 2020

CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling.

Cell death & disease

Huang R,Wang S,Wang N,Zheng Y,Zhou J,Yang B,Wang X,Zhang J,Guo L,Wang S,Chen Z,Wang Z,Xiang S

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Apr 16 00:00:00 EDT 2020

Profiling and Targeting of Energy and Redox Metabolism in Grade 2 Bladder Cancer Cells with Different Invasiveness Properties.

Cells

Pasquale V,Ducci G,Campioni G,Ventrici A,Assalini C,Busti S,Vanoni M,Vago R,Sacco E

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Dec 11 00:00:00 EST 2020

Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals.

Cell & bioscience

Jiang M,Ye J,Wang X,Li N,Wang Y,Shi Y

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Apr 14 00:00:00 EDT 2022

Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease.

Cell reports

Nguyen HD,Ticer T,Bastian D,Kuril S,Li H,Du H,Yan C,Yu XZ

12-0441 was used in Flow cytometry/Cell sorting to reveal the role of LAL in T cell alloresponse and pathogenicity and validates LAL as a target for controlling GVHD and tumor relapse after allo-HCT.

Tue Oct 27 00:00:00 EDT 2020

Olfactomedin 4 mediation of prostate stem/progenitor-like cell proliferation and differentiation via MYC.

Scientific reports

Li H,Chaitankar V,Zhu J,Chin K,Liu W,Pirooznia M,Rodgers GP

12-0441-82 was used in Flow Cytometry to indicate that OLFM4 is co-expressed with multiple stem/progenitor cell marker genes in prostate epithelial cells and acts as a novel mediator in prostate stem/progenitor cell proliferation and differentiation.

Mon Dec 14 00:00:00 EST 2020

Tissue-Resident PDGFRα⁺ Progenitor Cells Contribute to Fibrosis versus Healing in a Context- and Spatiotemporally Dependent Manner.

Cell reports

Santini MP,Malide D,Hoffman G,Pandey G,D'Escamard V,Nomura-Kitabayashi A,Rovira I,Kataoka H,Ochando J,Harvey RP,Finkel T,Kovacic JC

12-0441 was used in Flow cytometry/Cell sorting to support a context-dependent "yin-yang" biology of tissue-resident mesenchymal progenitor cells, which possess an innate ability to limit injury expansion while also promoting fibrosis in an unfavorable environment.

Tue Jan 14 00:00:00 EST 2020

Requirements for the differentiation of innate T-bet^high memory-phenotype CD4⁺ T lymphocytes under steady state.

Nature communications

Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Jul 06 00:00:00 EDT 2020

Increased FGF-23 levels are linked to ineffective erythropoiesis and impaired bone mineralization in myelodysplastic syndromes.

JCI insight

Weidner H,Baschant U,Lademann F,Ledesma Colunga MG,Balaian E,Hofbauer C,Misof BM,Roschger P,Blouin S,Richards WG,Platzbecker U,Hofbauer LC,Rauner M

12-0441-82 was used in Flow Cytometry to identify FGF-23 as a link between altered bone structure and ineffective erythropoiesis in MDS with the prospects of a targeted therapeutic intervention.

Thu Aug 06 00:00:00 EDT 2020

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.

Nature communications

Toubal A,Kiaf B,Beaudoin L,Cagninacci L,Rhimi M,Fruchet B,da Silva J,Corbett AJ,Simoni Y,Lantz O,Rossjohn J,McCluskey J,Lesnik P,Maguin E,Lehuen A

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Jul 24 00:00:00 EDT 2020

Localized cocktail chemoimmunotherapy after in situ gelation to trigger robust systemic antitumor immune responses.

Science advances

Chao Y,Liang C,Tao H,Du Y,Wu D,Dong Z,Jin Q,Chen G,Xu J,Xiao Z,Chen Q,Wang C,Chen J,Liu Z

12-0441-82 was used in Flow Cytometry to report several "cocktail" therapeutic formulations by mixing immunogenic cell death (ICD)-inducing chemotherapeutics and immune adjuvants together with alginate (ALG) for localized chemoimmunotherapy.

Sun Mar 01 00:00:00 EST 2020

Localized cocktail chemoimmunotherapy after in situ gelation to trigger robust systemic antitumor immune responses.

Science advances

Chao Y,Liang C,Tao H,Du Y,Wu D,Dong Z,Jin Q,Chen G,Xu J,Xiao Z,Chen Q,Wang C,Chen J,Liu Z

Sun Mar 01 00:00:00 EST 2020

A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation.

Circulation research

Lu X,Rudemiller NP,Wen Y,Ren J,Hammer GE,Griffiths R,Privratsky JR,Yang B,Sparks MA,Crowley SD

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Dec 06 00:00:00 EST 2019

A Novel Form of 4-1BBL Prevents Cancer Development via Nonspecific Activation of CD4⁺ T and Natural Killer Cells.

Cancer research

Barsoumian HB,Batra L,Shrestha P,Bowen WS,Zhao H,Egilmez NK,Gomez-Gutierrez JG,Yolcu ES,Shirwan H

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Feb 15 00:00:00 EST 2019

Single-Cell Analysis Reveals Regulatory Gene Expression Dynamics Leading to Lineage Commitment in Early T Cell Development.

Cell systems

Zhou W,Yui MA,Williams BA,Yun J,Wold BJ,Cai L,Rothenberg EV

12-0441 was used in Flow cytometry/Cell sorting to imply that multilineage priming is integral to T cell specification.

Wed Oct 23 00:00:00 EDT 2019

Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice.

Genome research

Alriyami M,Marchand L,Li Q,Du X,Olivier M,Polychronakos C

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Sun Dec 01 00:00:00 EST 2019

The ROP16III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival.

PLoS pathogens

Tuladhar S,Kochanowsky JA,Bhaskara A,Ghotmi Y,Chandrasekaran S,Koshy AA

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Integrin α9 depletion promotes β-catenin degradation to suppress triple-negative breast cancer tumor growth and metastasis.

International journal of cancer

Wang Z,Li Y,Xiao Y,Lin HP,Yang P,Humphries B,Gao T,Yang C

12-0441 was used in Flow cytometry/Cell sorting to indicate that ITGA9 depletion suppresses TNBC tumor growth and metastasis by promoting β-catenin degradation through the ILK/PKA/GSK3 pathway.

Fri Nov 15 00:00:00 EST 2019

Anisomycin inhibits angiogenesis in ovarian cancer by attenuating the molecular sponge effect of the lncRNA‑Meg3/miR‑421/PDGFRA axis.

International journal of oncology

Ye W,Ni Z,Yicheng S,Pan H,Huang Y,Xiong Y,Liu T

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Sun Dec 01 00:00:00 EST 2019

Hypoxia changes chemotaxis behaviour of mesenchymal stem cells via HIF-1α signalling.

Journal of cellular and molecular medicine

Xu W,Xu R,Li Z,Wang Y,Hu R

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2019

Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro.

Stem cells international

Sun B,Luo X,Yang C,Liu P,Yang Y,Dong X,Yang Z,Xu J,Zhang Y,Li L

12-0441 was used in Flow cytometry/Cell sorting to demonstrate that urine-derived stem cells (USC) therapy significantly improves the renal function and histological damage, inhibited the inflammation and apoptosis processes in the kidney, and promoted tubular epithelial proliferation.

Thu May 13 00:00:00 EDT 2021

HMGB3 silence inhibits breast cancer cell proliferation and tumor growth by interacting with hypoxia-inducible factor 1α.

Cancer management and research

Gu J,Xu T,Huang QH,Zhang CM,Chen HY

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Sep 29 00:00:00 EDT 2020

TGF‑β induces periodontal ligament stem cell senescence through increase of ROS production.

Molecular medicine reports

Fan C,Ji Q,Zhang C,Xu S,Sun H,Li Z

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Rats provide a superior model of human stress erythropoiesis.

Experimental hematology

Zhang J,Liu Y,Han X,Mei Y,Yang J,Zhang ZJ,Lu X,Ji P

12-0441 was used in Flow cytometry/Cell sorting to establish rat in vitro and in vivo erythropoiesis models that are more appropriate and superior for the study of human stress erythropoiesis than mouse models.

Tue Oct 01 00:00:00 EDT 2019

Altered expression of leptin and leptin receptor in the development of immune-mediated aplastic anemia in mice.

Experimental and therapeutic medicine

Yin X,Yang J,Liu Y,Zhang J,Xin C,Zhao H,Wang W,Shi X,Cui Z,Li G,Zhao C,Liu X

12-0441 was used in Flow cytometry/Cell sorting to develop an aplastic anemia mouse model in order to study the role of leptin and leptin receptor in the differentiation of mesenchymal stem cells into adipocytes.

Thu Aug 01 00:00:00 EDT 2019

Effects of demographic factors on adipogenic and chondrogenic differentiation in bone marrow-derived stem cells.

Experimental and therapeutic medicine

Lee H,Min SK,Park JB

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed May 01 00:00:00 EDT 2019

The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway.

EBioMedicine

Seo D,Jung SM,Park JS,Lee J,Ha J,Kim M,Park SH

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Nov 01 00:00:00 EDT 2019

IL-17 inhibits CXCL9/10-mediated recruitment of CD8⁺ cytotoxic T cells and regulatory T cells to colorectal tumors.

Journal for immunotherapy of cancer

Chen J,Ye X,Pitmon E,Lu M,Wan J,Jellison ER,Adler AJ,Vella AT,Wang K

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Nov 27 00:00:00 EST 2019

IL-17 inhibits CXCL9/10-mediated recruitment of CD8⁺ cytotoxic T cells and regulatory T cells to colorectal tumors.

Journal for immunotherapy of cancer

Chen J,Ye X,Pitmon E,Lu M,Wan J,Jellison ER,Adler AJ,Vella AT,Wang K

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Nov 27 00:00:00 EST 2019

BRCA1 regulates the cancer stem cell fate of breast cancer cells in the context of hypoxia and histone deacetylase inhibitors.

Scientific reports

Kim H,Lin Q,Yun Z

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Jul 04 00:00:00 EDT 2019

Visfatin Mediates Malignant Behaviors through Adipose-Derived Stem Cells Intermediary in Breast Cancer.

Cancers

Huang JY,Wang YY,Lo S,Tseng LM,Chen DR,Wu YC,Hou MF,Yuan SF

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Dec 20 00:00:00 EST 2019

Autophagy Regulation of Metabolism Is Required for CD8⁺ T Cell Anti-tumor Immunity.

Cell reports

DeVorkin L,Pavey N,Carleton G,Comber A,Ho C,Lim J,McNamara E,Huang H,Kim P,Zacharias LG,Mizushima N,Saitoh T,Akira S,Beckham W,Lorzadeh A,Moksa M,Cao Q,Murthy A,Hirst M,DeBerardinis RJ,Lum JJ

12-0441 was used in Flow cytometry/Cell sorting to demonstrate a cell-autonomous role for autophagy in the regulation of CD8+ T-cell-mediated control of tumors.

Tue Apr 09 00:00:00 EDT 2019

Long noncoding RNA MALAT1 mediates stem cell-like properties in human colorectal cancer cells by regulating miR-20b-5p/Oct4 axis.

Journal of cellular physiology

Tang D,Yang Z,Long F,Luo L,Yang B,Zhu R,Sang X,Cao G,Wang K

12-0441-82 was used in Flow cytometry/Cell sorting to explore the mechanisms through which CSCs maintain their stemness, especially in tumors of colorectal cancer (CRC).

Fri Nov 01 00:00:00 EDT 2019

Better therapeutic potential of bone marrow-derived mesenchymal stem cells compared with chorionic villi-derived mesenchymal stem cells in airway injury model.

Regenerative medicine

Ji S,Wu C,Tong L,Wang L,Zhou J,Chen C,Song Y

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2019

Overexpression of Aiolos promotes epithelial-mesenchymal transition and cancer stem cell-like properties in lung cancer cells.

Scientific reports

Hung JJ,Kao YS,Huang CH,Hsu WH

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Feb 28 00:00:00 EST 2019

Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1.

Cell reports

Gawish R,Bulat T,Biaggio M,Lassnig C,Bago-Horvath Z,Macho-Maschler S,Poelzl A,Simonović N,Prchal-Murphy M,Rom R,Amenitsch L,Ferrarese L,Kornhoff J,Lederer T,Svinka J,Eferl R,Bosmann M,Kalinke U,Stoiber D,Sexl V,Krmpotić A,Jonjić S,Müller M,Strobl B

12-0441 was used in Flow cytometry/Cell sorting to provide genetic evidence that signaling through STAT1 in myeloid cells is required to restrict MCMV at early time points post-infection and to induce compensatory hematopoiesis in the spleen.

Tue Feb 26 00:00:00 EST 2019

BMX-ARHGAP fusion protein maintains the tumorigenicity of gastric cancer stem cells by activating the JAK/STAT3 signaling pathway.

Cancer cell international

Xu XF,Gao F,Wang JJ,Long C,Chen X,Tao L,Yang L,Ding L,Ji Y

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Apr 08 00:00:00 EDT 2022

Sex Differences in Mouse Popliteal Lymph Nodes.

Scientific reports

Dill-Garlow R,Chen KE,Walker AM

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Jan 30 00:00:00 EST 2019

ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.

Nature communications

Cao Y,Trillo-Tinoco J,Sierra RA,Anadon C,Dai W,Mohamed E,Cen L,Costich TL,Magliocco A,Marchion D,Klar R,Michel S,Jaschinski F,Reich RR,Mehrotra S,Cubillos-Ruiz JR,Munn DH,Conejo-Garcia JR,Rodriguez PC

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Mar 20 00:00:00 EDT 2019

Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice.

Nature communications

Yue W,Chen L,Yu L,Zhou B,Yin H,Ren W,Liu C,Guo L,Zhang Y,Sun L,Zhang K,Xu H,Chen Y

Thu May 02 00:00:00 EDT 2019

Bone-derived Nestin-positive mesenchymal stem cells improve cardiac function via recruiting cardiac endothelial cells after myocardial infarction.

Stem cell research & therapy

Lu D,Liao Y,Zhu SH,Chen QC,Xie DM,Liao JJ,Feng X,Jiang MH,He W

12-0441 was used in Flow cytometry/Cell sorting to show that Nestin is a useful marker for the identification of functional BMSCs and indicate that Nestin+ BMSCs could be a better therapeutic candidate for cardiac repair.

Sat Apr 27 00:00:00 EDT 2019

Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair.

Cell reports

Colunga T,Hayworth M,Kreß S,Reynolds DM,Chen L,Nazor KL,Baur J,Singh AM,Loring JF,Metzger M,Dalton S

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Mar 05 00:00:00 EST 2019

Growth Factor Screening in Dystrophic Muscles Reveals PDGFB/PDGFRB-Mediated Migration of Interstitial Stem Cells.

International journal of molecular sciences

Camps J,Grosemans H,Gijsbers R,Maes C,Sampaolesi M

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Mar 05 00:00:00 EST 2019

Conserved regulation of RNA processing in somatic cell reprogramming.

BMC genomics

Kanitz A,Syed AP,Kaji K,Zavolan M

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Jan 31 00:00:00 EST 2019

Interleukin-17-Producing γδ T Cells Originate from SOX13⁺ Progenitors that Are Independent of γδTCR Signaling.

Immunity

Spidale NA,Sylvia K,Narayan K,Miu B,Frascoli M,Melichar HJ,Zhihao W,Kisielow J,Palin A,Serwold T,Love P,Kobayashi M,Yoshimoto M,Jain N,Kang J

12-0441-82 was used in Flow Cytometry to generate reporter mice for the Tγδ17 lineage-defining transcription factor SOX13 and identify fetal-origin, intrathymic Sox13+ progenitors.

Tue Nov 20 00:00:00 EST 2018

Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency.

Cell stem cell

Mor N,Rais Y,Sheban D,Peles S,Aguilera-Castrejon A,Zviran A,Elinger D,Viukov S,Geula S,Krupalnik V,Zerbib M,Chomsky E,Lasman L,Shani T,Bayerl J,Gafni O,Hanna S,Buenrostro JD,Hagai T,Masika H,Vainorius G,Bergman Y,Greenleaf WJ,Esteban MA,Elling U,Levin Y,Massarwa R,Merbl Y,Novershtern N,Hanna JH

12-0441 was used in Flow cytometry/Cell sorting to propose that the Gatad2a-Chd4-Mbd3/NuRD complex is critical for blocking reestablishment of naive pluripotency.

Thu Sep 06 00:00:00 EDT 2018

Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.

The Journal of clinical investigation

Zhao B,Mei Y,Cao L,Zhang J,Sumagin R,Yang J,Gao J,Schipma MJ,Wang Y,Thorsheim C,Zhao L,Stalker T,Stein B,Wen QJ,Crispino JD,Abrams CS,Ji P

12-0441 was used in Flow cytometry/Cell sorting to identify pleckstrin-2 as an effector of the JAK2/STAT5 pathway and a key factor in the pathogenesis of JAK2V617F-induced myeloproliferative neoplasms.

Tue Jan 02 00:00:00 EST 2018

Bryostatin-1 alleviates experimental multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Feb 27 00:00:00 EST 2018

Lenalidomide and Programmed Death-1 Blockade Synergistically Enhances the Effects of Dendritic Cell Vaccination in a Model of Murine Myeloma.

Frontiers in immunology

Vo MC,Jung SH,Chu TH,Lee HJ,Lakshmi TJ,Park HS,Kim HJ,Rhee JH,Lee JJ

12-0441 was used in Flow cytometry/Cell sorting to investigate the efficacy of dendritic cell vaccination in combination with lenalidomide and PD-1 blockade in a model of murine myeloma.

Sun Jan 03 00:00:00 EST 2021

Photochemical Internalization of Peptide Antigens Provides a Novel Strategy to Realize Therapeutic Cancer Vaccination.

Frontiers in immunology

Haug M,Brede G,Håkerud M,Nedberg AG,Gederaas OA,Flo TH,Edwards VT,Selbo PK,Høgset A,Halaas Ø

12-0441 was used in Flow cytometry/Cell sorting to study the ability of photochemical internalisation as a vaccination technology to induce priming of cancer-specific CD8+ cytotoxic T lymphocytes.

Mon Jun 24 00:00:00 EDT 2019

Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.

Oncogene

Solomon H,Dinowitz N,Pateras IS,Cooks T,Shetzer Y,Molchadsky A,Charni M,Rabani S,Koifman G,Tarcic O,Porat Z,Kogan-Sakin I,Goldfinger N,Oren M,Harris CC,Gorgoulis VG,Rotter V

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Mar 01 00:00:00 EST 2018

The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells.

Breast cancer research : BCR

Kim H,Lin Q,Glazer PM,Yun Z

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Mar 06 00:00:00 EST 2018

SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer.

The Journal of cell biology

Viotti M,Wilson C,McCleland M,Koeppen H,Haley B,Jhunjhunwala S,Klijn C,Modrusan Z,Arnott D,Classon M,Stephan JP,Mellman I

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Feb 05 00:00:00 EST 2018

SOX4 contributes to TGF-β-induced epithelial-mesenchymal transition and stem cell characteristics of gastric cancer cells.

Genes & diseases

Peng X,Liu G,Peng H,Chen A,Zha L,Wang Z

12-0441 was used in Flow cytometry/Cell sorting to study a novel role of the TGF-Β/SOX4 signalling axis in the regulation of malignant behaviour of gastric cancer.

Thu Mar 01 00:00:00 EST 2018

Human Bone Marrow Contains Mesenchymal Stromal Stem Cells That Differentiate In Vitro into Contractile Myofibroblasts Controlling T Lymphocyte Proliferation.

Stem cells international

Lecarpentier Y,Schussler O,Sakic A,Rincon-Garriz JM,Soulie P,Bochaton-Piallat ML,Kindler V

12-0441 was used in Flow cytometry/Cell sorting to show that bone marrow derived mesenchymal stromal stem cells cultured in collagen membranes spontaneously differentiate into contractile myofibroblasts exhibiting unexpected properties.

Sun Nov 12 00:00:00 EST 2023

CXCL12 modulates the radiosensitivity of cervical cancer by regulating CD44.

Molecular medicine reports

Fu Z,Zhang P,Luo H,Huang H,Wang F

12-0441 was used in Flow cytometry/Cell sorting to investigate the regulation of stromal cell-derived factor 1 (CXCL12) in the radioresistance of cervical cancer, which was upregulated in tumors in our previous study.

Sat Dec 01 00:00:00 EST 2018

Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43.

Experimental and therapeutic medicine

Li Z,Zhang S,Cao L,Li W,Ye YC,Shi ZX,Wang ZR,Sun LX,Wang JW,Jia LT,Wang W

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Simultaneous isolation of mesenchymal stem cells and endothelial progenitor cells derived from murine bone marrow.

Experimental and therapeutic medicine

Wang X,Zhao Z,Zhang H,Hou J,Feng W,Zhang M,Guo J,Xia J,Ge Q,Chen X,Wu X

12-0441 was used in Flow cytometry/Cell sorting to develop a method for the simultaneous isolation of homogenous populations of mesenchymal stem or stromal cells and endothelial progenitor cells from murine bone marrow.

Sat Dec 01 00:00:00 EST 2018

mTOR Modulates CD8+ T Cell Differentiation in Mice with Invasive Pulmonary Aspergillosis.

Open life sciences

Wang H,Xiao Y,Su L,Cui N,Liu D

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Jan 01 00:00:00 EST 2018

Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.

Nature communications

Sun C,Lan P,Han Q,Huang M,Zhang Z,Xu G,Song J,Wang J,Wei H,Zhang J,Sun R,Zhang C,Tian Z

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Mar 28 00:00:00 EDT 2018

Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling.

Nature communications

Piao W,Xiong Y,Famulski K,Brinkman CC,Li L,Toney N,Wagner C,Saxena V,Simon T,Bromberg JS

12-0441 was used in Flow cytometry/Cell sorting to demonstrate the importance of LTΒR signaling in leukocyte migration and LEC and lymphatic vessel function, and show that antagonist peptides may serve as lead compounds for therapeutic applications.

Wed Aug 01 00:00:00 EDT 2018

Inhibition of Fas associated phosphatase 1 (Fap1) facilitates apoptosis of colon cancer stem cells and enhances the effects of oxaliplatin.

Oncotarget

Huang W,Bei L,Eklund EA

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri May 25 00:00:00 EDT 2018

An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer.

eLife

Li J,Choi PS,Chaffer CL,Labella K,Hwang JH,Giacomelli AO,Kim JW,Ilic N,Doench JG,Ly SH,Dai C,Hagel K,Hong AL,Gjoerup O,Goel S,Ge JY,Root DE,Zhao JJ,Brooks AN,Weinberg RA,Hahn WC

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Jul 30 00:00:00 EDT 2018

Hyaluronan Receptor LYVE-1-Expressing Macrophages Maintain Arterial Tone through Hyaluronan-Mediated Regulation of Smooth Muscle Cell Collagen.

Immunity

Lim HY,Lim SY,Tan CK,Thiam CH,Goh CC,Carbajo D,Chew SHS,See P,Chakarov S,Wang XN,Lim LH,Johnson LA,Lum J,Fong CY,Bongso A,Biswas A,Goh C,Evrard M,Yeo KP,Basu R,Wang JK,Tan Y,Jain R,Tikoo S,Choong C,Weninger W,Poidinger M,Stanley RE,Collin M,Tan NS,Ng LG,Jackson DG,Ginhoux F,Angeli V

12-0441-82 was used in Blocking experiments to unveil a hitherto unknown homeostatic contribution of arterial LYVE-1+ macrophages through the control of collagen production by SMCs and has identified a function of LYVE-1 in leukocytes.

Tue Aug 21 00:00:00 EDT 2018

Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.

Nature communications

Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Nov 08 00:00:00 EST 2018

Helminth-induced IL-4 expands bystander memory CD8⁺ T cells for early control of viral infection.

Nature communications

Rolot M,Dougall AM,Chetty A,Javaux J,Chen T,Xiao X,Machiels B,Selkirk ME,Maizels RM,Hokke C,Denis O,Brombacher F,Vanderplasschen A,Gillet L,Horsnell WGC,Dewals BG

12-0441 was used in Flow cytometry/Cell sorting to study whether helminth-induced type 2 immunity functionally affects the T virtual memory cell compartment.

Tue Oct 30 00:00:00 EDT 2018

Mesenchymal stromal cells-derived matrix Gla protein contribute to the alleviation of experimental colitis.

Cell death & disease

Feng Y,Liao Y,Huang W,Lai X,Luo J,Du C,Lin J,Zhang Z,Qiu D,Liu Q,Shen H,Xiang AP,Zhang Q

12-0441 was used in Flow cytometry/Cell sorting to study the role of matrix Gla protein as a novel mediator of mesenchymal stromal cell-mediated immunomodulation in treating Crohn's disease.

Thu Jun 07 00:00:00 EDT 2018

RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.

The Journal of biological chemistry

Ge J,Burnier L,Adamopoulou M,Kwa MQ,Schaks M,Rottner K,Brakebusch C

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Jun 15 00:00:00 EDT 2018

Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation.

Cell reports

Chiou NT,Kageyama R,Ansel KM

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Dec 18 00:00:00 EST 2018

Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.

Cancer cell

Turaj AH,Hussain K,Cox KL,Rose-Zerilli MJJ,Testa J,Dahal LN,Chan HTC,James S,Field VL,Carter MJ,Kim HJ,West JJ,Thomas LJ,He LZ,Keler T,Johnson PWM,Al-Shamkhani A,Thirdborough SM,Beers SA,Cragg MS,Glennie MJ,Lim SH

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Dec 11 00:00:00 EST 2017

A Predictive Model for Selective Targeting of the Warburg Effect through GAPDH Inhibition with a Natural Product.

Cell metabolism

Liberti MV,Dai Z,Wardell SE,Baccile JA,Liu X,Gao X,Baldi R,Mehrmohamadi M,Johnson MO,Madhukar NS,Shestov AA,Chio IIC,Elemento O,Rathmell JC,Schroeder FC,McDonnell DP,Locasale JW

12-0441 was used in Flow cytometry/Cell sorting to develop a predictive model for selective targeting of the Warburg effect.

Tue Oct 03 00:00:00 EDT 2017

Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.

Cell stem cell

Ruetz T,Pfisterer U,Di Stefano B,Ashmore J,Beniazza M,Tian TV,Kaemena DF,Tosti L,Tan W,Manning JR,Chantzoura E,Ottosson DR,Collombet S,Johnsson A,Cohen E,Yusa K,Linnarsson S,Graf T,Parmar M,Kaji K

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Dec 07 00:00:00 EST 2017

Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.

The Journal of clinical investigation

Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

The Journal of experimental medicine

Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Jun 05 00:00:00 EDT 2017

Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.

Cancer research

Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B

12-0441-82 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.

Wed Nov 01 00:00:00 EDT 2017

KDM4 Inhibition Targets Breast Cancer Stem-like Cells.

Cancer research

Metzger E,Stepputtis SS,Strietz J,Preca BT,Urban S,Willmann D,Allen A,Zenk F,Iovino N,Bronsert P,Proske A,Follo M,Boerries M,Stickeler E,Xu J,Wallace MB,Stafford JA,Kanouni T,Maurer J,Schüle R

12-0441 was used in Flow cytometry/Cell sorting to validate a BCSC culture system for drug screening and proof of concept for KDM4 inhibition as a triple-negative breast cancer treatment.

Wed Nov 01 00:00:00 EDT 2017

Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells.

Proceedings of the National Academy of Sciences of the United States of America

Bierie B,Pierce SE,Kroeger C,Stover DG,Pattabiraman DR,Thiru P,Liu Donaher J,Reinhardt F,Chaffer CL,Keckesova Z,Weinberg RA

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Mar 21 00:00:00 EDT 2017

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

Proceedings of the National Academy of Sciences of the United States of America

Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL

12-0441-82 was used in Flow cytometry/Cell sorting to show that transfusion of red blood cells expressing self-antigen epitopes can alleviate and even prevent signs of disease in experimental autoimmune encephalomyelitis, as well as maintain normoglycemia in a mouse model of type 1 diabetes.

Tue Mar 21 00:00:00 EDT 2017

Opposing effects on the cell cycle of T lymphocytes by Fbxo7 via Cdk6 and p27.

Cellular and molecular life sciences : CMLS

Patel SP,Randle SJ,Gibbs S,Cooke A,Laman H

12-0441 was used in Flow cytometry/Cell sorting to test the physiological role of an F-box protein, Fbxo7, in multiple tissues.

Sat Apr 01 00:00:00 EDT 2017

Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8⁺ T-cell Differentiation during the Immune Response to Invasive Pulmonary Aspergillosis.

Chinese medical journal

Cui N,Wang H,Su LX,Zhang JH,Long Y,Liu DW

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Sat May 20 00:00:00 EDT 2017

CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells.

Journal of leukocyte biology

Myles IA,Zhao M,Nardone G,Olano LR,Reckhow JD,Saleem D,Break TJ,Lionakis MS,Myers TG,Gardina PJ,Kirkpatrick CH,Holland SM,Datta SK

12-0441 was used in Flow cytometry/Cell sorting to show that extracts from antigen-targeted T cells enhance immunity to Staphylococcus aureus and Candida albicans.

Sun Jan 01 00:00:00 EST 2017

The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice.

Journal of immunology (Baltimore, Md. : 1950)

Sitrin J,Suto E,Wuster A,Eastham-Anderson J,Kim JM,Austin CD,Lee WP,Behrens TW

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Aug 15 00:00:00 EDT 2017

Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.

Journal of immunology (Baltimore, Md. : 1950)

Dolina JS,Cechova S,Rudy CK,Sung SJ,Tang WW,Lee J,Hahn YS,Le TH

12-0441 was used in Flow cytometry/Cell sorting to identify the functional role of collectrin in the liver.

Wed Mar 15 00:00:00 EDT 2017

A high-yield isolation and enrichment strategy for human lung microvascular endothelial cells.

Pulmonary circulation

Gaskill C,Majka SM

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Modulation of Innate Immunity by lignin-Carbohydrate, a Novel TLR4 Ligand, Results in Augmentation of Mucosal IgA and Systemic IgG Production.

International journal of molecular sciences

Tsuji R,Ikado K,Fujiwara D

12-0441 was used in Flow cytometry/Cell sorting to investigate immune-stimulatory activity of lignin-rich enzyme lignin in vivo.

Tue Dec 26 00:00:00 EST 2017

Comparison of Four Protocols to Generate Chondrocyte-Like Cells from Human Induced Pluripotent Stem Cells (hiPSCs).

Stem cell reviews and reports

Suchorska WM,Augustyniak E,Richter M,Trzeciak T

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

Interleukin-21 combined with PD-1 or CTLA-4 blockade enhances antitumor immunity in mouse tumor models.

Oncoimmunology

Lewis KE,Selby MJ,Masters G,Valle J,Dito G,Curtis WR,Garcia R,Mink KA,Waggie KS,Holdren MS,Grosso JF,Korman AJ,Jure-Kunkel M,Dillon SR

12-0441 was used in Flow cytometry/Cell sorting to investigate the efficacy of immune-modulatory interleukin-21 combined with checkpoint blockade in several syngeneic mouse tumor models.

Tue Jan 12 00:00:00 EST 2021

Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4.

Nature communications

Campos Carrascosa L,Klein M,Kitagawa Y,Lückel C,Marini F,König A,Guralnik A,Raifer H,Hagner-Benes S,Rädler D,Böck A,Kang C,Lohoff M,Garn H,Schaub B,Berberich-Siebelt F,Sakaguchi S,Bopp T,Huber M

12-0441 was used in Flow cytometry/Cell sorting to study the opposing effects of interferon regulatory factor1 and IRF4 on T helper 9 cell differentiation.

Fri May 12 00:00:00 EDT 2017

Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.

Scientific reports

Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Sep 29 00:00:00 EDT 2017

Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.

Nature communications

Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Oct 11 00:00:00 EDT 2017

Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling.

Theranostics

Cao Y,Lin SH,Wang Y,Chin YE,Kang L,Mi J

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Apr 30 00:00:00 EDT 2018

IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.

JCI insight

Le Saout C,Luckey MA,Villarino AV,Smith M,Hasley RB,Myers TG,Imamichi H,Park JH,O'Shea JJ,Lane HC,Catalfamo M

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Nov 16 00:00:00 EST 2017

SOCS3 treatment prevents the development of alopecia areata by inhibiting CD8+ T cell-mediated autoimmune destruction.

Oncotarget

Gao Z,Jin YQ,Wu W

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue May 16 00:00:00 EDT 2017

A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection.

Scientific reports

Yi P,Liang Y,Yuan DMK,Jie Z,Kwota Z,Chen Y,Cong Y,Fan X,Sun J

12-0441 was used in Flow cytometry/Cell sorting to reveal a significant effect of the IL-23/PI3K/mTORC1 axis on regulating IL-22 production and also identify a novel role of IL-22 in controlling antiviral T cell responses in the non-lymphoid and lymphoid organs during acute and persistent viral infections.

Tue Jun 20 00:00:00 EDT 2017

Ceramide synthesis regulates T cell activity and GVHD development.

JCI insight

Sofi MH,Heinrichs J,Dany M,Nguyen H,Dai M,Bastian D,Schutt S,Wu Y,Daenthanasanmak A,Gencer S,Zivkovic A,Szulc Z,Stark H,Liu C,Chang YJ,Ogretmen B,Yu XZ

12-0441 was used in Flow cytometry/Cell sorting to define the involvement of ceramides in the T-cell response to alloantigens present after allogeneic haematopoietic cell transplantation.

Thu May 18 00:00:00 EDT 2017

Extrafollicular CD4⁺ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.

Nature communications

Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

Extrafollicular CD4⁺ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.

Nature communications

Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB.

PloS one

Gao SY,Zheng GS,Wang L,Liang YJ,Zhang SE,Lao XM,Li K,Liao GQ

12-0441 was used in Flow cytometry/Cell sorting to study the effect of biphosphonates suppressed proteosteoclasts releasing PDGF-BB, and their role in coupling angiogenesis and osteogenesis in BRONJ manifestation.

Mon Sep 18 00:00:00 EDT 2017

Feasibility of placenta-derived mesenchymal stem cells as a tool for studying pregnancy-related disorders.

Scientific reports

Fuchi N,Miura K,Doi H,Li TS,Masuzaki H

12-0441 was used in Flow cytometry/Cell sorting to evaluate the feasibility of using placenta-derived mesenchymal stem cells as a tool to study pregnancy related disorders.

Wed Apr 12 00:00:00 EDT 2017

The cryo-thermal therapy eradicated melanoma in mice by eliciting CD4⁺ T-cell-mediated antitumor memory immune response.

Cell death & disease

He K,Liu P,Xu LX

12-0441 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic efficacy in other aggressive tumor models and further investigate the mechanism of long-term survival induced.

Thu Mar 23 00:00:00 EDT 2017

NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.

Nature

Ma C,Kesarwala AH,Eggert T,Medina-Echeverz J,Kleiner DE,Jin P,Stroncek DF,Terabe M,Kapoor V,ElGindi M,Han M,Thornton AM,Zhang H,Egger M,Luo J,Felsher DW,McVicar DW,Weber A,Heikenwalder M,Greten TF

12-0441 was used in Flow cytometry/Cell sorting to demonstrate that dysregulation of lipid metabolism in NAFLD causes selective loss of CD4(+) T lymphocytes, promoting hepatocarcinogenesis.

Thu Mar 10 00:00:00 EST 2016

Blood pressure regulation by CD4⁺ lymphocytes expressing choline acetyltransferase.

Nature biotechnology

Olofsson PS,Steinberg BE,Sobbi R,Cox MA,Ahmed MN,Oswald M,Szekeres F,Hanes WM,Introini A,Liu SF,Holodick NE,Rothstein TL,Lövdahl C,Chavan SS,Yang H,Pavlov VA,Broliden K,Andersson U,Diamond B,Miller EJ,Arner A,Gregersen PK,Backx PH,Mak TW,Tracey KJ

12-0441 was used in Flow cytometry/Cell sorting to identify CD4 ChAT cells as immune contributors in maintaining blood pressure homeostasis.

Sat Oct 01 00:00:00 EDT 2016

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.

Cell

Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D

12-0441 was used in Flow cytometry/Cell sorting to study how OTULIN may be critical in restraining life-threatening spontaneous inflammation and maintaining immune homeostasis.

Thu Aug 25 00:00:00 EDT 2016

Oligodendrocyte death results in immune-mediated CNS demyelination.

Nature neuroscience

Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells.

Leukemia

Wen S,Dooner M,Cheng Y,Papa E,Del Tatto M,Pereira M,Deng Y,Goldberg L,Aliotta J,Chatterjee D,Stewart C,Carpanetto A,Collino F,Bruno S,Camussi G,Quesenberry P

12-0441 was used in Flow cytometry/Cell sorting to evaluate the capacity of mesenchymal stromal cell-derived extracellular vesicles to rescue murine marrow hematopoietic cells damage following exposure to radiation, showing that damage could be reversed using both murine and human MSC-EVs.

Tue Nov 01 00:00:00 EDT 2016

SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis.

PLoS biology

Kim BR,Van de Laar E,Cabanero M,Tarumi S,Hasenoeder S,Wang D,Virtanen C,Suzuki T,Bandarchi B,Sakashita S,Pham NA,Lee S,Keshavjee S,Waddell TK,Tsao MS,Moghal N

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Nov 01 00:00:00 EDT 2016

IL-12 and IL-4 activate a CD39-dependent intrinsic peripheral tolerance mechanism in CD8(+) T cells.

European journal of immunology

Noble A,Mehta H,Lovell A,Papaioannou E,Fairbanks L

12-0441 was used in Flow cytometry/Cell sorting to study the upregulation of CD39 on CD8(+) T cells and identify a novel pathway of peripheral tolerance.

Wed Jun 01 00:00:00 EDT 2016

Stem Cells Antigen-1 Enriches for a Cancer Stem Cell-Like Subpopulation in Mouse Gastric Cancer.

Stem cells (Dayton, Ohio)

Park JW,Park JM,Park DM,Kim DY,Kim HK

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.

Journal of immunology (Baltimore, Md. : 1950)

Menendez CM,Jinkins JK,Carr DJ

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Aug 15 00:00:00 EDT 2016

Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.

Journal of immunology (Baltimore, Md. : 1950)

Song Y,Kumar V,Wei HX,Qiu J,Stanley P

12-0441 was used in Flow cytometry/Cell sorting to investigate the roles for maniac fringe (MFNG) and radical fringe (RFNG) in T cell development, RFNG in B cell development, and Fringes in T and B cell activation, showing that they promote T and B cell development.

Fri Jan 01 00:00:00 EST 2016

Effects of nerve growth factor and basic fibroblast growth factor dual gene modification on rat bone marrow mesenchymal stem cell differentiation into neuron-like cells in vitro.

Molecular medicine reports

Hu Y,Zhang Y,Tian K,Xun C,Wang S,Lv D

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Comparable roles of CD44v8-10 and CD44s in the development of bone metastases in a mouse model.

Oncology letters

Hiraga T,Nakamura H

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2016

Cryptotanshinone targets tumor-initiating cells through down-regulation of stemness genes expression.

Oncology letters

Zhang Y,Cabarcas SM,Zheng JI,Sun L,Mathews LA,Zhang X,Lin H,Farrar WL

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Jun 01 00:00:00 EDT 2016

PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.

Biology open

Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Sun May 15 00:00:00 EDT 2016

Sertoli cell condition medium can induce germ like cells from bone marrow derived mesenchymal stem cells.

Iranian journal of basic medical sciences

Monfared MH,Minaee B,Rastegar T,Khrazinejad E,Barbarestani M

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Nov 01 00:00:00 EDT 2016

A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.

Nature communications

Jeric I,Maurer G,Cavallo AL,Raguz J,Desideri E,Tarkowski B,Parrini M,Fischer I,Zatloukal K,Baccarini M

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Dec 21 00:00:00 EST 2016

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.

Nature communications

Brinkman CC,Iwami D,Hritzo MK,Xiong Y,Ahmad S,Simon T,Hippen KL,Blazar BR,Bromberg JS

12-0441 was used in Magnetic cell separation to studying Treg cell engagement with the lymphotoxin beta receptor in transendothelial migration.

Tue Jun 21 00:00:00 EDT 2016

B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation.

Scientific reports

Bjarnadóttir K,Benkhoucha M,Merkler D,Weber MS,Payne NL,Bernard CCA,Molnarfi N,Lalive PH

12-0441-82 was used in Flow Cytometry to test the role for transforming growth factor-β1 expression in regulatory B cell function in autoimmune neuroinflammation.

Thu Oct 06 00:00:00 EDT 2016

Potency of umbilical cord blood- and Wharton's jelly-derived mesenchymal stem cells for scarless wound healing.

Scientific reports

Doi H,Kitajima Y,Luo L,Yan C,Tateishi S,Ono Y,Urata Y,Goto S,Mori R,Masuzaki H,Shimokawa I,Hirano A,Li TS

12-0441 was used in Flow cytometry/Cell sorting to determine that umbilical cord blood offers a potential source of MSCs for therapeutic scarless wound healing.

Tue Jan 05 00:00:00 EST 2016

Synovial fluid pretreatment with hyaluronidase facilitates isolation of CD44+ extracellular vesicles.

Journal of extracellular vesicles

Boere J,van de Lest CH,Libregts SF,Arkesteijn GJ,Geerts WJ,Nolte-'t Hoen EN,Malda J,van Weeren PR,Wauben MH

12-0441 was used in Flow cytometry/Cell sorting to facilitate recovery and detection of CD44+ EVs within the HA-rich extracellular matrix.

Thu Aug 11 00:00:00 EDT 2016

The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states.

BMC biology

Toneff MJ,Sreekumar A,Tinnirello A,Hollander PD,Habib S,Li S,Ellis MJ,Xin L,Mani SA,Rosen JM

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Jun 17 00:00:00 EDT 2016

Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production.

Stem cell research & therapy

Camilleri ET,Gustafson MP,Dudakovic A,Riester SM,Garces CG,Paradise CR,Takai H,Karperien M,Cool S,Sampen HJ,Larson AN,Qu W,Smith J,Dietz AB,van Wijnen AJ

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Aug 11 00:00:00 EDT 2016

Stat3 Signaling Promotes Survival And Maintenance Of Medullary Thymic Epithelial Cells.

PLoS genetics

Lomada D,Jain M,Bolner M,Reeh KA,Kang R,Reddy MC,DiGiovanni J,Richie ER

12-0441 was used in Flow cytometry/Cell sorting to demonstrate that in addition to the NFkB pathway, Stat3-mediated signals play an essential role in regulating mTEC cellularity and medullary region homeostasis.

Fri Jan 01 00:00:00 EST 2016

Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration.

Oncotarget

Greenwood E,Maisel S,Ebertz D,Russ A,Pandey R,Schroeder J

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Sep 20 00:00:00 EDT 2016

Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy.

Nature communications

Chen Q,Xu L,Liang C,Wang C,Peng R,Liu Z

12-0441 was used in Immunohistochemistry to investigate the use of immuneadjuvant nanoparticles for photothermal tumour ablation in mice and their potential for cancer immunotherapy.

Fri Oct 21 00:00:00 EDT 2016

Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle.

The Journal of clinical investigation

Quattrocelli M,Swinnen M,Giacomazzi G,Camps J,Barthélemy I,Ceccarelli G,Caluwé E,Grosemans H,Thorrez L,Pelizzo G,Muijtjens M,Verfaillie CM,Blot S,Janssens S,Sampaolesi M

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2015

Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.

Cancer research

Zhang S,Chung WC,Wu G,Egan SE,Miele L,Xu K

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri May 15 00:00:00 EDT 2015

Asporin Is a Fibroblast-Derived TGF-β1 Inhibitor and a Tumor Suppressor Associated with Good Prognosis in Breast Cancer.

PLoS medicine

Maris P,Blomme A,Palacios AP,Costanza B,Bellahcène A,Bianchi E,Gofflot S,Drion P,Trombino GE,Di Valentin E,Cusumano PG,Maweja S,Jerusalem G,Delvenne P,Lifrange E,Castronovo V,Turtoi A

12-0441 was used in Flow cytometry/Cell sorting to show that asporin is a stroma-derived inhibitor of TGF-β1 and a tumor suppressor in breast cancer and indicate the direction of pre-clinical studies.

Tue Sep 01 00:00:00 EDT 2015

Premature thymic involution is independent of structural plasticity of the thymic stroma.

European journal of immunology

Franckaert D,Schlenner SM,Heirman N,Gill J,Skogberg G,Ekwall O,Put K,Linterman MA,Dooley J,Liston A

12-0441 was used in Flow cytometry/Cell sorting to investigate thymic involution in FVB/N mice, showing that disruption of the epithelial-endothelial relationship and a progressive loss of pro-T cells precedes involution, and loss of pro-T cells is sufficient to drive premature involution, suggesting that pro-T cells are the main driver of involution.

Fri May 01 00:00:00 EDT 2015

The expression of mouse CLEC-2 on leucocyte subsets varies according to their anatomical location and inflammatory state.

European journal of immunology

Lowe KL,Navarro-Núñez L,Bénézech C,Nayar S,Kingston BL,Nieswandt B,Barone F,Watson SP,Buckley CD,Desanti GE

12044182 was used in flow cytometry to assess surface expression of C-type lectin-like receptor 2 on hematopoietic cells from peripheral blood and secondary lymphoid organs

Tue Sep 01 00:00:00 EDT 2015

Mouse bone marrow-derived mesenchymal stem cells inhibit leukemia/lymphoma cell proliferation in vitro and in a mouse model of allogeneic bone marrow transplant.

International journal of molecular medicine

Song N,Gao L,Qiu H,Huang C,Cheng H,Zhou H,Lv S,Chen L,Wang J

12-0441 was used in Flow cytometry/Cell sorting to determine that MSCs may be safe and effective when used in allogeneic BMT for the treatment of haemotological malignancies.

Wed Jul 01 00:00:00 EDT 2015

CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer.

Cancer medicine

Yoshida K,Tsujimoto H,Matsumura K,Kinoshita M,Takahata R,Matsumoto Y,Hiraki S,Ono S,Seki S,Yamamoto J,Hase K

12-0441 was used in Flow cytometry/Cell sorting to demonstrate that higher expressions of CD44 and CD47 in gastric cancer cells correlate with higher proliferation and tumorigenicity.

Tue Sep 01 00:00:00 EDT 2015

Enrichment of Human Stem-Like Prostate Cells with s-SHIP Promoter Activity Uncovers a Role in Stemness for the Long Noncoding RNA H19.

Stem cells and development

Bauderlique-Le Roy H,Vennin C,Brocqueville G,Spruyt N,Adriaenssens E,Bourette RP

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri May 15 00:00:00 EDT 2015

Multi-Drug Resistance ABC Transporter Inhibition Enhances Murine Ventral Prostate Stem/Progenitor Cell Differentiation.

Stem cells and development

Samant MD,Jackson CM,Felix CL,Jones AJ,Goodrich DW,Foster BA,Huss WJ

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri May 15 00:00:00 EDT 2015

Special AT-rich sequence-binding protein-1 participates in the maintenance of breast cancer stem cells through regulation of the Notch signaling pathway and expression of Snail1 and Twist1.

Molecular medicine reports

Sun Z,Zhang C,Zou X,Jiang G,Xu Z,Li W,Xie H

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2015

Reprogramming Roadblocks Are System Dependent.

Stem cell reports

Chantzoura E,Skylaki S,Menendez S,Kim SI,Johnsson A,Linnarsson S,Woltjen K,Chambers I,Kaji K

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Sep 08 00:00:00 EDT 2015

Multi-lineage differentiation of human umbilical cord Wharton's Jelly Mesenchymal Stromal Cells mediates changes in the expression profile of stemness markers.

PloS one

Ali H,Al-Yatama MK,Abu-Farha M,Behbehani K,Al Madhoun A

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Mar 25 00:00:00 EDT 2016

Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.

Cell transplantation

Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P

12-0441-82 was used in Flow cytometry/Cell sorting to suggest that physiological differences between fibroblast-like cell populations might lie at the basis of variations in histopathological and/or clinical outcome following cell grafting in mouse brain.

Mon Nov 16 00:00:00 EST 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

12-0441 was used in Flow cytometry/Cell sorting to demonstrate amelioration of experimental autoimmune encephalomyelitis by a blood brain barrier permeable peptide to deliver ctCTLA-4 protein.

Tue Sep 15 00:00:00 EDT 2015

Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spatial learning and memory in mouse middle cerebral artery occlusion model.

Stem cell research & therapy

Zhou F,Gao S,Wang L,Sun C,Chen L,Yuan P,Zhao H,Yi Y,Qin Y,Dong Z,Cao L,Ren H,Zhu L,Li Q,Lu B,Liang A,Xu GT,Zhu H,Gao Z,Ma J,Xu J,Chen X

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Sat May 09 00:00:00 EDT 2015

Allogeneic mesenchymal stem cells inhibited T follicular helper cell generation in rheumatoid arthritis.

Scientific reports

Liu R,Li X,Zhang Z,Zhou M,Sun Y,Su D,Feng X,Gao X,Shi S,Chen W,Sun L

12-0441 was used in Flow cytometry/Cell sorting to reveal a novel suppressive function of mesenchymal stem cells with implications for the treatment of rheumatoid arthritis.

Tue Aug 11 00:00:00 EDT 2015

CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload.

Circulation

Laroumanie F,Douin-Echinard V,Pozzo J,Lairez O,Tortosa F,Vinel C,Delage C,Calise D,Dutaur M,Parini A,Pizzinat N

12-0441 was used in Flow cytometry/Cell sorting to investigate the involvement of T cells in the progression to heart failure using a transverse aortic constriction (TAC) model.

Tue May 27 00:00:00 EDT 2014

Intravascular staining for discrimination of vascular and tissue leukocytes.

Nature protocols

Anderson KG,Mayer-Barber K,Sung H,Beura L,James BR,Taylor JJ,Qunaj L,Griffith TS,Vezys V,Barber DL,Masopust D

12-0441 was used in Immunofluorescence to outline a protocol for the validation and use of intravascular staining to define innate and adaptive immune cells in mice.

Wed Jan 01 00:00:00 EST 2014

CCR10 regulates balanced maintenance and function of resident regulatory and effector T cells to promote immune homeostasis in the skin.

The Journal of allergy and clinical immunology

Xia M,Hu S,Fu Y,Jin W,Yi Q,Matsui Y,Yang J,McDowell MA,Sarkar S,Kalia V,Xiong N

12-0441 was used in Flow cytometry/Cell sorting to investigate the functional importance of CCR10/CCL27 in vivo, showing that CCR10 regulates maintenance and function of regulatory and effector T cells to promote immune homeostasis.

Mon Sep 01 00:00:00 EDT 2014

Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.

Autophagy

Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y

12-0441 was used in Flow cytometry/Cell sorting to study how inflammatory microenvironment-induced autophagy can downregulate the immunosuppressive function of mesenchymal stem cells.

Tue Jul 01 00:00:00 EDT 2014

Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation.

eLife

Baptista AP,Roozendaal R,Reijmers RM,Koning JJ,Unger WW,Greuter M,Keuning ED,Molenaar R,Goverse G,Sneeboer MM,den Haan JM,Boes M,Mebius RE

12-0441 was used in Flow cytometry/Cell sorting to investigate the role of MHC-II in lymph node stromal cells, showing that stromal cells constrain immunity through MHC-II expression.

Wed Nov 19 00:00:00 EST 2014

T Cell factor 1 represses CD8+ effector T cell formation and function.

Journal of immunology (Baltimore, Md. : 1950)

Tiemessen MM,Baert MR,Kok L,van Eggermond MC,van den Elsen PJ,Arens R,Staal FJ

12-0441 was used in Flow cytometry/Cell sorting to explore the role of the Wnt-responsive transcription factor T cell factor 1 in the initial phases of CD8(+) T effector cell formation.

Mon Dec 01 00:00:00 EST 2014

An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection.

Genes and immunity

Lafferty EI,Flaczyk A,Angers I,Homer R,d'Hennezel E,Malo D,Piccirillo CA,Vidal SM,Qureshi ST

12-0441 was used in Flow cytometry/Cell sorting to establish a role for Unc93b1 and endosomal TLRs in the activation of both myeloid and lymphoid cells during the innate immune response to influenza.

Fri Apr 10 00:00:00 EDT 2015

Serum- and growth-factor-free three-dimensional culture system supports cartilage tissue formation by promoting collagen synthesis via Sox9-Col2a1 interaction.

Tissue engineering. Part A

Ahmed N,Iu J,Brown CE,Taylor DW,Kandel RA

12-0441 was used in Flow cytometry/Cell sorting to define the conditions necessary for chondrocytes to form cartilage tissue in vitro.

Fri Aug 01 00:00:00 EDT 2014

Serum- and growth-factor-free three-dimensional culture system supports cartilage tissue formation by promoting collagen synthesis via Sox9-Col2a1 interaction.

Tissue engineering. Part A

Ahmed N,Iu J,Brown CE,Taylor DW,Kandel RA

12-0441 was used in Flow cytometry/Cell sorting to define the conditions necessary for chondrocytes to form cartilage tissue in vitro.

Fri Aug 01 00:00:00 EDT 2014

Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation.

Neoplasia (New York, N.Y.)

Zhang S,Chung WC,Wu G,Egan SE,Xu K

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Sat Feb 01 00:00:00 EST 2014

FOXF1 mediates mesenchymal stem cell fusion-induced reprogramming of lung cancer cells.

Oncotarget

Wei HJ,Nickoloff JA,Chen WH,Liu HY,Lo WC,Chang YT,Yang PC,Wu CW,Williams DF,Gelovani JG,Deng WP

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Wed Oct 15 00:00:00 EDT 2014

BMP-non-responsive Sca1+ CD73+ CD44+ mouse bone marrow derived osteoprogenitor cells respond to combination of VEGF and BMP-6 to display enhanced osteoblastic differentiation and ectopic bone formation.

PloS one

Madhu V,Li CJ,Dighe AS,Balian G,Cui Q

12-0441 was used in Flow cytometry/Cell sorting to study how combined action of VEGF and BMP on MSCs enhances osteoblastic differentiation of MSCs and increases their bone forming ability.

Fri Nov 20 00:00:00 EST 2015

Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.

PloS one

Xiao GY,Liu IH,Cheng CC,Chang CC,Lee YH,Cheng WT,Wu SC

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu May 28 00:00:00 EDT 2015

Validation of the effects of TGF-β1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical properties.

Cancer cell international

Wu TH,Chou YW,Chiu PH,Tang MJ,Hu CW,Yeh ML

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Mar 03 00:00:00 EST 2014

Cytoskeletal regulation of CD44 membrane organization and interactions with E-selectin.

The Journal of biological chemistry

Wang Y,Yago T,Zhang N,Abdisalaam S,Alexandrakis G,Rodgers W,McEver RP

12-0441 was used in Flow cytometry/Cell sorting to demonstrate that spectrin and actin networks regulate CD44 clustering and suggest that ankyrin enhances CD44-mediated neutrophil rolling and signaling.

Fri Dec 19 00:00:00 EST 2014

High-resolution analysis with novel cell-surface markers identifies routes to iPS cells.

Nature

O'Malley J,Skylaki S,Iwabuchi KA,Chantzoura E,Ruetz T,Johnsson A,Tomlinson SR,Linnarsson S,Kaji K

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Jul 04 00:00:00 EDT 2013

Expression of intercellular adhesion molecule 1 by hepatocellular carcinoma stem cells and circulating tumor cells.

Gastroenterology

Liu S,Li N,Yu X,Xiao X,Cheng K,Hu J,Wang J,Zhang D,Cheng S,Liu S

12-0441 was used in Flow cytometry/Cell sorting to demonstrate that the stem cell factor Nanog regulates expression of ICAM-1 in hepatocellular carcinoma cells.

Wed May 01 00:00:00 EDT 2013

miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.

Nature cell biology

Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2013

GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.

Nature cell biology

Chou J,Lin JH,Brenot A,Kim JW,Provot S,Werb Z

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2013

GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.

Nature cell biology

Chou J,Lin JH,Brenot A,Kim JW,Provot S,Werb Z

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2013

MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.

The Journal of experimental medicine

Molnarfi N,Schulze-Topphoff U,Weber MS,Patarroyo JC,Prod'homme T,Varrin-Doyer M,Shetty A,Linington C,Slavin AJ,Hidalgo J,Jenne DE,Wekerle H,Sobel RA,Bernard CC,Shlomchik MJ,Zamvil SS

12-0441 was used in Flow cytometry/Cell sorting to investigate the contribution of B cells to antigen presentation and pathogenic T cell activation in the multiple sclerosis model experimental autoimmune encephalomyelitis.

Mon Dec 16 00:00:00 EST 2013

Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion.

Cancer research

Ferrari-Amorotti G,Fragliasso V,Esteki R,Prudente Z,Soliera AR,Cattelani S,Manzotti G,Grisendi G,Dominici M,Pieraccioli M,Raschellà G,Chiodoni C,Colombo MP,Calabretta B

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2013

Protection of islet grafts through transforming growth factor-β-induced tolerogenic dendritic cells.

Diabetes

Thomas DC,Wong FS,Zaccone P,Green EA,Wållberg M

12-0441 was used in Flow cytometry/Cell sorting to investigate methods to achieve long-term β-islet graft tolerance for diabetes type 1, showing that islets can be protected through expression of TGF-β.

Sun Sep 01 00:00:00 EDT 2013

Mesenchymal stem cells are mobilized from the bone marrow during inflammation.

Frontiers in immunology

Koning JJ,Kooij G,de Vries HE,Nolte MA,Mebius RE

12-0441 was used in Flow cytometry/Cell sorting to analyse mesenchymal stem- and T-cell migration during experimental allergic encephalomyelitis.

Wed Mar 06 00:00:00 EST 2013

Evidence for a multipotent mammary progenitor with pregnancy-specific activity.

Breast cancer research : BCR

Kaanta AS,Virtanen C,Selfors LM,Brugge JS,Neel BG

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Dec 08 00:00:00 EST 2014

Mesenchymal stem cells play an important role in host protective immune responses against malaria by modulating regulatory T cells.

European journal of immunology

Thakur RS,Tousif S,Awasthi V,Sanyal A,Atul PK,Punia P,Das J

12-0441 was used in Flow cytometry/Cell sorting to report that Plasmodium berghei infection of mice leads to massive recruitment of mesenchymal stem cells in secondary lymphoid organs.

Thu Aug 01 00:00:00 EDT 2013

Cellular-FLIP, Raji isoform (c-FLIP R) modulates cell death induction upon T-cell activation and infection.

European journal of immunology

Telieps T,Ewald F,Gereke M,Annemann M,Rauter Y,Schuster M,Ueffing N,von Smolinski D,Gruber AD,Bruder D,Schmitz I

12-0441 was used in Flow cytometry/Cell sorting to study the induction of endogenous murine cellular-FLIPR in activated lymphocytes.

Sat Jun 01 00:00:00 EDT 2013

The CD44+ ALDH+ population of human keratinocytes is enriched for epidermal stem cells with long-term repopulating ability.

Stem cells (Dayton, Ohio)

Szabo AZ,Fong S,Yue L,Zhang K,Strachan LR,Scalapino K,Mancianti ML,Ghadially R

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Apr 01 00:00:00 EDT 2013

Estrogen and progesterone together expand murine endometrial epithelial progenitor cells.

Stem cells (Dayton, Ohio)

Janzen DM,Cheng D,Schafenacker AM,Paik DY,Goldstein AS,Witte ON,Jaroszewicz A,Pellegrini M,Memarzadeh S

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Apr 01 00:00:00 EDT 2013

Ontogeny and localization of the cells produce IL-2 in healthy animals.

Cytokine

Yamamoto M,Seki Y,Iwai K,Ko I,Martin A,Tsuji N,Miyagawa S,Love RB,Iwashima M

12-0441 was used in Flow cytometry/Cell sorting to study how a group of Tr1 cells may have additional roles in immune homeostasis through IL-2 production to aid in the maintenance of other regulatory T cells..

Fri Mar 01 00:00:00 EST 2013

Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.

PloS one

Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K

12-0441 was used in Flow cytometry/Cell sorting to show how Nod2 activates NF-kB in CD4+ T cells, but its expression is dispensable for T cell-induced colitis.

Thu Jul 31 00:00:00 EDT 2014

Roscovitine suppresses CD4+ T cells and T cell-mediated experimental uveitis.

PloS one

Zhang Z,Liu Q,Leskov KS,Wu X,Duan J,Zhang GL,Hall M,Rosenbaum JT

12-0441 was used in Flow cytometry/Cell sorting to test the immunosuppressive effect of roscovitine, a potent CdK2 inhibitor, on CD4+ T cell activation, proliferation, and function.

Mon Jun 30 00:00:00 EDT 2014

Increased invasion and tumorigenicity capacity of CD44+/CD24- breast cancer MCF7 cells in vitro and in nude mice.

Cancer cell international

Yan W,Chen Y,Yao Y,Zhang H,Wang T

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Mon Jun 24 00:00:00 EDT 2013

Microvesicles derived from human umbilical cord Wharton's jelly mesenchymal stem cells attenuate bladder tumor cell growth in vitro and in vivo.

PloS one

Wu S,Ju GQ,Du T,Zhu YJ,Liu GH

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue Oct 22 00:00:00 EDT 2013

γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response.

Immunity

Zeng X,Wei YL,Huang J,Newell EW,Yu H,Kidd BA,Kuhns MS,Waters RW,Davis MM,Weaver CT,Chien YH

12-0441 was used in Flow cytometry/Cell sorting to study the γδ T cell response to the algae protein, phycoerythrin.

Fri Sep 21 00:00:00 EDT 2012

Alterations of peripheral CD4+CD25+Foxp3+ T regulatory cells in mice with STZ-induced diabetes.

Cellular & molecular immunology

Zhen Y,Sun L,Liu H,Duan K,Zeng C,Zhang L,Jin D,Peng J,Ding W,Zhao Y

12-0441 was used in Flow cytometry/Cell sorting to investigate the effect of hyperglycemia on CD4+CD25+Tregs, showing alterations of peripheral CD4+CD25+Foxp3+ Tregs in STZ-induced diabetes.

Sun Jan 01 00:00:00 EST 2012

Trogocytosis of CD80 and CD86 by induced regulatory T cells.

Cellular & molecular immunology

Gu P,Gao JF,D'Souza CA,Kowalczyk A,Chou KY,Zhang L

12-0441 was used in Flow cytometry/Cell sorting to provide a novel understanding of the interaction between iTregs and DCs, and its role in iTreg-mediated immune suppression.

Thu Mar 01 00:00:00 EST 2012

Increased CD8+ T-cell function following castration and immunization is countered by parallel expansion of regulatory T cells.

Cancer research

Tang S,Moore ML,Grayson JM,Dubey P

12-0441 was used in Flow cytometry/Cell sorting to evaluate the effects of concomitant castration and immunisation on T cell function in mice.

Sun Apr 15 00:00:00 EDT 2012

Increased protection from vaccinia virus infection in mice genetically prone to lymphoproliferative disorders.

Journal of virology

Seedhom MO,Mathurin KS,Kim SK,Welsh RM

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Jun 01 00:00:00 EDT 2012

Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation.

Stem cells (Dayton, Ohio)

Paik DY,Janzen DM,Schafenacker AM,Velasco VS,Shung MS,Cheng D,Huang J,Witte ON,Memarzadeh S

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Nov 01 00:00:00 EDT 2012

Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection.

Journal of immunology (Baltimore, Md. : 1950)

Panzer M,Sitte S,Wirth S,Drexler I,Sparwasser T,Voehringer D

12-0441 was used in Flow cytometry/Cell sorting to determine whether different classes of T cells can be converted into IL-4-expressing Th2 cells in vivo by infection of mice with gastrointestinal helminth.

Sun Jan 15 00:00:00 EST 2012

Donor B cells in transplants augment clonal expansion and survival of pathogenic CD4+ T cells that mediate autoimmune-like chronic graft-versus-host disease.

Journal of immunology (Baltimore, Md. : 1950)

Young JS,Wu T,Chen Y,Zhao D,Liu H,Yi T,Johnston H,Racine J,Li X,Wang A,Todorov I,Zeng D

12-0441 was used in Flow cytometry/Cell sorting to investigate the mechanisms whereby donor B cells augment chronic graft-versus-host disease (cGVHD) pathogenesis, showing that B cells augment clonal expansion and survival of pathogenic CD4+ T cells that mediate autoimmune-like cGVHD.

Sun Jul 01 00:00:00 EDT 2012

A critical role for Rictor in T lymphopoiesis.

Journal of immunology (Baltimore, Md. : 1950)

Tang F,Wu Q,Ikenoue T,Guan KL,Liu Y,Zheng P

12-0441 was used in Flow cytometry/Cell sorting to investigate the signalling pathway required for T lymphopoiesis, showing a critical role for Rictor.

Wed Aug 15 00:00:00 EDT 2012

Downregulation of Mcl-1 synergizes the apoptotic response to combined treatment with cisplatin and a novel fiber chimeric oncolytic adenovirus.

Oncology reports

You L,Wang Y,Jin Y,Qian W

12-0441 was used in Flow cytometry/Cell sorting to determine how SG511 sensitises cancer cells to apoptosis by reducing anti-apoptotic Mcl-1 protein levels.

Sun Apr 01 00:00:00 EDT 2012

The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering.

The Journal of biological chemistry

Yang C,Cao M,Liu H,He Y,Xu J,Du Y,Liu Y,Wang W,Cui L,Hu J,Gao F

12-0441 was used in Flow cytometry/Cell sorting to elucidate a molecular- and/or cellular-based mechanism for the biological activities of nHA and oHA.

Fri Dec 14 00:00:00 EST 2012

The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering.

The Journal of biological chemistry

Yang C,Cao M,Liu H,He Y,Xu J,Du Y,Liu Y,Wang W,Cui L,Hu J,Gao F

12-0441 was used in Flow cytometry/Cell sorting to elucidate a molecular- and/or cellular-based mechanism for the biological activities of nHA and oHA.

Fri Dec 14 00:00:00 EST 2012

The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering.

The Journal of biological chemistry

Yang C,Cao M,Liu H,He Y,Xu J,Du Y,Liu Y,Wang W,Cui L,Hu J,Gao F

12-0441 was used in Flow cytometry/Cell sorting to elucidate a molecular- and/or cellular-based mechanism for the biological activities of nHA and oHA.

Fri Dec 14 00:00:00 EST 2012

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.

Nature communications

Yae T,Tsuchihashi K,Ishimoto T,Motohara T,Yoshikawa M,Yoshida GJ,Wada T,Masuko T,Mogushi K,Tanaka H,Osawa T,Kanki Y,Minami T,Aburatani H,Ohmura M,Kubo A,Suematsu M,Takahashi K,Saya H,Nagano O

12-0441 was used in Flow cytometry/Cell sorting to show that epithelial splicing regulatory protein 1-CD44v-xCT axis is thus a potential therapeutic target for the prevention of metastasis.

Wed Jun 06 00:00:00 EDT 2012

Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells.

PloS one

Caserta S,Nausch N,Sawtell A,Drummond R,Barr T,Macdonald AS,Mutapi F,Zamoyska R

12-0441 was used in Flow cytometry/Cell sorting to study the expression of the CD200 receptor on CD4 T cells in response to chronic infection.

Thu Aug 23 00:00:00 EDT 2012

Residual tumor cells that drive disease relapse after chemotherapy do not have enhanced tumor initiating capacity.

PloS one

Hegde GV,de la Cruz C,Eastham-Anderson J,Zheng Y,Sweet-Cordero EA,Jackson EL

12-0441 was used in Flow cytometry/Cell sorting to determine whether tumor re-initiating cells (TRICs) display characteristics of cancer stem cells.

Tue Apr 23 00:00:00 EDT 2013

A critical role for SOCS3 in innate resistance to Toxoplasma gondii.

Cell host & microbe

Whitmarsh RJ,Gray CM,Gregg B,Christian DA,May MJ,Murray PJ,Hunter CA

12-0441 was used in Flow cytometry/Cell sorting to study the role of SOCS3 in suppressing IL-6 signalling during immune responses to T. gondii infection.

Thu Sep 15 00:00:00 EDT 2011

Centrosome docking at the immunological synapse is controlled by Lck signaling.

The Journal of cell biology

Tsun A,Qureshi I,Stinchcombe JC,Jenkins MR,de la Roche M,Kleczkowska J,Zamoyska R,Griffiths GM

12-0441 was used in Flow cytometry/Cell sorting to investigate the role of Lck signalling in the control of centrosome docking at the immunological synapse.

Mon Feb 21 00:00:00 EST 2011

Inferring relevant control mechanisms for interleukin-12 signaling in naïve CD4+ T cells.

Immunology and cell biology

Finley SD,Gupta D,Cheng N,Klinke DJ

12-0441 was used in Flow cytometry/Cell sorting to infer the relative importance of regulatory mechanisms that modulate the activation of STAT4 in naive CD4(+) T cells.

Sat Jan 01 00:00:00 EST 2011

Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility.

Journal of immunology (Baltimore, Md. : 1950)

Kondilis-Mangum HD,Shih HY,Mahowald G,Sleckman BP,Krangel MS

12-0441 was used in Flow cytometry/Cell sorting to analyse the contributions of chromatin accessibility and locus conformation to feedback inhibition.

Thu Dec 15 00:00:00 EST 2011

Alloreactive CD8 T-cell primed/memory responses and accelerated graft rejection in B-cell-deficient sensitized mice.

Transplantation

Ji H,Shen XD,Gao F,Busuttil RW,Zhai Y,Kupiec-Weglinski JW

12-0441 was used in Flow cytometry/Cell sorting to investigate the role of B cell deficiency in primed/memory CD8+ T cell responses and the mechanism of cardiac allograft rejection in sensitised mouse recipients.

Fri May 27 00:00:00 EDT 2011

GLI1 confers profound phenotypic changes upon LNCaP prostate cancer cells that include the acquisition of a hormone independent state.

PloS one

Nadendla SK,Hazan A,Ward M,Harper LJ,Moutasim K,Bianchi LS,Naase M,Ghali L,Thomas GJ,Prowse DM,Philpott MP,Neill GW

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Sep 30 00:00:00 EDT 2011

Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths.

Immunity

Ohnmacht C,Schwartz C,Panzer M,Schiedewitz I,Naumann R,Voehringer D

12-0441 was used in Flow cytometry/Cell sorting to demonstrate that basophils play an important role for protective immunity against helminths and orchestrate chronic allergic inflammation.

Fri Sep 24 00:00:00 EDT 2010

Tumor masses support naive T cell infiltration, activation, and differentiation into effectors.

The Journal of experimental medicine

Thompson ED,Enriquez HL,Fu YX,Engelhard VH

12-0441 was used in Flow cytometry/Cell sorting to study the ways in which tumour masses support naive T cell functions.

Mon Aug 02 00:00:00 EDT 2010

Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells.

Journal of immunology (Baltimore, Md. : 1950)

Tait ED,Jordan KA,Dupont CD,Harris TH,Gregg B,Wilson EH,Pepper M,Dzierszinski F,Roos DS,Hunter CA

12-0441 was used in Flow cytometry/Cell sorting to show the dendritic cell response to T.gondii alters levels of CD8+ T cells which ultimately determine the outcome of infection.

Sun Aug 01 00:00:00 EDT 2010

Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism.

Journal of immunology (Baltimore, Md. : 1950)

Do JS,Fink PJ,Li L,Spolski R,Robinson J,Leonard WJ,Letterio JJ,Min B

12-0441 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the generation of gammadelta T cells, showing that it occurs via a TGF-beta 1-dependent mechanism.

Mon Feb 15 00:00:00 EST 2010

Additive and global functions of HoxA cluster genes in mesoderm derivatives.

Developmental biology

Di-Poï N,Koch U,Radtke F,Duboule D

12-0441 was used in Flow cytometry/Cell sorting to report that mutant mice lacking the entire HoxA cluster in mesodermal lineages display the expected spectrum of postnatal respiratory, cardiac and urogenital defects, previously reported for single gene mutations.

Sat May 15 00:00:00 EDT 2010

Cell-cell cooperation at the T helper cell/mast cell immunological synapse.

Blood

Gaudenzio N,Espagnolle N,Mars LT,Liblau R,Valitutti S,Espinosa E

12-0441 was used in Flow cytometry/Cell sorting to investigate whether cognate interactions between mast cells and class II-restricted CD4(+) T cells occur.

Thu Dec 03 00:00:00 EST 2009

MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization.

The Journal of clinical investigation

Vagima Y,Avigdor A,Goichberg P,Shivtiel S,Tesio M,Kalinkovich A,Golan K,Dar A,Kollet O,Petit I,Perl O,Rosenthal E,Resnick I,Hardan I,Gellman YN,Naor D,Nagler A,Lapidot T

12-0441 was used in Flow cytometry/Cell sorting to study the mechanisms governing haematopoietic progenitor cell mobilisation.

Sun Mar 01 00:00:00 EST 2009

Naringenin: a potential immunomodulator for inhibiting lung fibrosis and metastasis.

Cancer research

Du G,Jin L,Han X,Song Z,Zhang H,Liang W

12-0441 was used in Flow cytometry/Cell sorting to determine whether mouse models of idiopathic pulmonary fibrosis have high incidence of lung cancer, showing that Naringenin could treat lung fibrosis and metastasis.

Wed Apr 01 00:00:00 EDT 2009

Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway.

PLoS pathogens

Kemball CC,Harkins S,Whitmire JK,Flynn CT,Feuer R,Whitton JL

12-0441 was used in Flow cytometry/Cell sorting to evaluate in vitro and in vivo antigen presentation by coxsackievirus B3, showing that it inhibits antigen presentation in vivo.

Thu Oct 01 00:00:00 EDT 2009

Human CD8+CXCR3+ T cells have the same function as murine CD8+CD122+ Treg.

European journal of immunology

Shi Z,Okuno Y,Rifa'i M,Endharti AT,Akane K,Isobe K,Suzuki H

12-0441-82 was used in Flow Cytometry to suggest that human CD8(+)CXCR3(+) T cells are the counterparts of murine CD8(+)CD122(+) Treg.

Sat Aug 01 00:00:00 EDT 2009

Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation.

Journal of immunology (Baltimore, Md. : 1950)

Lal G,Zhang N,van der Touw W,Ding Y,Ju W,Bottinger EP,Reid SP,Levy DE,Bromberg JS

12-0441 was used in Flow cytometry/Cell sorting to investigate Foxp3 as the master switch for Tregs, showing that expression is regulated by DNA methylation in Tregs.

Thu Jan 01 00:00:00 EST 2009

Scalable analysis of flow cytometry data using R/Bioconductor.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Klinke DJ,Brundage KM

12-0441 was used in Flow cytometry/Cell sorting to demonstrate usage of a platform for the graphical and data analysis of flow cytometry data.

Sat Aug 01 00:00:00 EDT 2009

Two host factors regulate persistence of H7-specific T cells injected in tumor-bearing mice.

PloS one

Meunier MC,Baron C,Perreault C

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Fri Feb 13 00:00:00 EST 2009

Effects of Culturing on the Stability of the Putative Murine Adipose Derived Stem Cells Markers.

The open stem cell journal

Maddox JR,Liao X,Li F,Niyibizi C

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2009

Activated CD8 T cells redistribute to antigen-free lymph nodes and exhibit effector and memory characteristics.

Journal of immunology (Baltimore, Md. : 1950)

Brinkman CC,Sheasley-O'Neill SL,Ferguson AR,Engelhard VH

12-0441 was used in Flow cytometry/Cell sorting to characterise the activation and differentiation of CD8 T cells in individual lymphoid compartments over time, and their migration between compartments.

Fri Aug 01 00:00:00 EDT 2008

Homeostasis and effector function of lymphopenia-induced "memory-like" T cells in constitutively T cell-depleted mice.

Journal of immunology (Baltimore, Md. : 1950)

Voehringer D,Liang HE,Locksley RM

12-0441-82 was used in Flow Cytometry to demonstrate that T(ML) cells are not sufficient to mediate an effective immune response in constitutively T cell-depleted mice.

Tue Apr 01 00:00:00 EDT 2008

Characterization of fibroblasts responsible for cartilage destruction in arthritis.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Treese C,Mittag A,Lange F,Tarnok A,Loesche A,Emmrich F,Lehmann J,Sack U

12-0441 was used in Flow cytometry/Cell sorting to show that LS48 is an excellent tool to gain a deeper understanding of synovial fibroblasts in rheumatoid arthritis.

Tue Apr 01 00:00:00 EDT 2008

Primary activation of antigen-specific naive CD4+ and CD8+ T cells following intranasal vaccination with recombinant bacteria.

Infection and immunity

Ciabattini A,Pettini E,Andersen P,Pozzi G,Medaglini D

12-0441 was used in Flow cytometry/Cell sorting to study the primary activation of T cells following mucosal immunisation with recombinant Streptococcus gordonii.

Mon Dec 01 00:00:00 EST 2008

Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.

Proceedings of the National Academy of Sciences of the United States of America

Tsuji M,Shinkura R,Kuroda K,Yabe D,Honjo T

12-0441-82 was used in Flow Cytometry to o investigate where and how Notch regulates early T cell differentiation by using specific up-regulation of Notch signaling by Mint knockout.

Tue Jan 30 00:00:00 EST 2007

Induction of potent CD8+ T-cell responses by novel biodegradable nanoparticles carrying human immunodeficiency virus type 1 gp120.

Journal of virology

Wang X,Uto T,Akagi T,Akashi M,Baba M

12-0441 was used in Flow cytometry/Cell sorting to attempt to construct an efficient protein-based vaccine using gamma-PGA nanoparticles, showing induction of potent CD8+ T-cell responses.

Sat Sep 01 00:00:00 EDT 2007

IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals.

Journal of immunology (Baltimore, Md. : 1950)

Li X,McKinstry KK,Swain SL,Dalton DK

12-0441 was used in Flow cytometry/Cell sorting to investigate IFN-γ-mediated apoptosis mechanisms of CD4+ T Cells during mycobacterial infection, which operate through induction of intra- and extracellular apoptosis signals.

Sun Jul 15 00:00:00 EDT 2007

Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection.

Infection and immunity

Anis MM,Fulton SA,Reba SM,Harding CV,Boom WH

Published figure using CD44 monoclonal antibody (Product # 12-0441-82) in Flow Cytometry

Tue May 01 00:00:00 EDT 2007

TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.

Immunity

Veldhoen M,Hocking RJ,Atkins CJ,Locksley RM,Stockinger B

12-0441 was used in Flow cytometry/Cell sorting to investigate the generation of IL-17-producing T cells from naive CD4 T cells, showing that TGFbeta supports de novo differentiation of IL-17-producing T cells.

Wed Feb 01 00:00:00 EST 2006

Aberrant contraction of antigen-specific CD4 T cells after infection in the absence of gamma interferon or its receptor.

Infection and immunity

Haring JS,Harty JT

12-0441 was used in Flow cytometry/Cell sorting to investigate the role of IFN-gamma in regulating the contraction of Ag-specific CD4 T cells, showing that the absence of IFN-gamma or its receptor after infection led to aberrant contraction of antigen-specific CD4 T cells.

Wed Nov 01 00:00:00 EST 2006

Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling.

Genes & development

Taghon TN,David ES,Zúñiga-Pflücker JC,Rothenberg EV

12-0441 was used in Flow cytometry/Cell sorting to study how Notch/Delta signaling is not sufficient for T-lineage specification and commitment, but can be permissive for the maintenance and proliferation of uncommitted progenitors.

Fri Apr 15 00:00:00 EDT 2005

TOX provides a link between calcineurin activation and CD8 lineage commitment.

The Journal of experimental medicine

Aliahmad P,O'Flaherty E,Han P,Goularte OD,Wilkinson B,Satake M,Molkentin JD,Kaye J

12-0441 was used in Flow cytometry/Cell sorting to demonstrate that up-regulation of TOX in double positive thymocytes is calcineurin dependent, linking the signalling pathway to nuclear changes that occur during positive thymocyte selection..

Mon Apr 19 00:00:00 EDT 2004

Bioinformatics

Protein Aliases: CD44; CD44 antigen; CD44 molecule; CDw44; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; ECMR-III; ECMRIII; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; hyaluronan receptor; Hyaluronate receptor; Ly-24; Lymphocyte antigen 24; PGP I; PGP-1; PGP-I; PGPI; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; sCD 44; sCD44; soluble CD 44; soluble CD44

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Gene Aliases: AU023126; AW121933; AW146109; CD44; CDW44; CSPG8; ECMR-III; HCELL; HERMES; HUTCH-I; IN; LHR; Ly-24; MC56; MDU2; MDU3; MIC4; Pgp-1; Pgp1

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UniProt ID: (Human) Q16064, (Mouse) P15379

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Entrez Gene ID: (Human) 960, (Mouse) 12505

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Function(s)

cytokine receptor activity protein binding collagen binding hyaluronic acid binding hyalurononglucosaminidase activity epidermal growth factor receptor binding protein kinase binding cytokine binding phosphoprotein binding transmembrane signal receptor

Process(es)

cell-matrix adhesion single organismal cell-cell adhesion extracellular matrix disassembly extracellular matrix organization hyaluronan catabolic process positive regulation of peptidyl-serine phosphorylation positive regulation of heterotypic cell-cell adhesion negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of DNA damage response, signal transduction by p53 class mediator cellular response to fibroblast growth factor stimulus positive regulation of peptidyl-tyrosine phosphorylation leukocyte migration cartilage development interferon-gamma-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade monocyte aggregation positive regulation of monocyte aggregation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of cell growth branching involved in ureteric bud morphogenesis wound healing involved in inflammatory response positive regulation of adaptive immune response negative regulation of mature B cell apoptotic process cell adhesion positive regulation of gene expression Wnt signaling pathway cell migration neuron projection development positive regulation of neutrophil apoptotic process macrophage fusion branching involved in prostate gland morphogenesis

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CD44 Monoclonal Antibody (IM7), PE, eBioscience™

CD44 Antibody (12-0441-82) in Flow

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12-0441-82

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