Invitrogen

CD44 Monoclonal Antibody (IM7), APC-eFluor™ 780, eBioscience™

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

96 Published Figures

192 References

View all (259) CD44 antibodies

Datasheet

Protocols

Questions & Answers

Tech Support

Datasheet

Protocols

Questions & Answers

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FIGURE: 1 / 99

CD44 Antibody (47-0441-82) in Flow

Staining of human peripheral blood mononuclear cells with CD45 Pacific Blue, CD61 FITC and CD44 APC-eFluor 780. As expected based on known relative expression patterns, CD44 clone IM7 stains a subset of CD45 negative cells (green), lymphocytes (pink), monocytes (orange) and granulocytes (blue).

Product Image Gallery

CD44 Antibody — Staining of human peripheral blood mononuclear cells with CD45 Pacific Blue, CD61 FITC and CD44 APC-eFluor 780. As expected based on known relative expression patterns, CD44 clone IM7 stains a subset of CD45 negative cells (green), lymphocytes (pink), monocytes (orange) and granulocytes (blue). {RE}

Product Details

47-0441-82

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

0.25 µg/test

View 192 publications 192 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Bat, Fruit fly, Human, Mouse, Non-human primate

Host/Isotype

Rat / IgG2b, kappa

Recommended Isotype Control

Rat IgG2b kappa Isotype Control (eB149/10H5), APC-eFluor™ 780, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

IM7

Conjugate

APC-eFluor™ 780 APC-eFluor™ 780 APC-eFluor™ 780

Excitation/Emission Max

756/785 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1272244

Product Specific Information

Description: The IM7 monoclonal antibody reacts with all isoforms of mouse CD44 (Pgp-1). CD44 is expressed by hematopoietic and non-hematopoietic cells. Bone marrow myeloid cells and memory T cells highly express this antigen and peripheral B and T cells can upregulate the expression of CD44. CD44 functions as an adhesion molecule through its binding to hyaluronate, an extracellular matrix component.

Applications Reported: This IM7 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This IM7 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

APC-eFluor 780 emits at 780 nm and is excited with the Red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome.

Light sensitivity: This tandem is sensitive to photo-induced oxidation. Please protect this vial and stained samples from light.

Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-8222) (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product # 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.

Excitation: 633-647 nm; Emission: 780 nm; Laser: Red Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD44 cell surface antigen is a 100 kDa type 1 transmembrane glycoprotein widely expressed on human leucocytes, white matter of the brain and by some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues. CD44 is a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, cell adhesion and migration. CD44 also participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing. CD44 expression may be up-regulated upon some carcinomas, and it has been speculated that this may be related to metastatic potential. CD44 is expressed by hematopoietic, non-hematopoietic cells, epithelial tissues, and to filopodia in cultured keratinocytes. Further, bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate the expression of CD44 in response to certain stimulatory events. Transcripts for the CD44 gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full-length nature of some of these variants have not been determined. Alternative splicing is the basis for the structural and functional diversity of the CD44 protein. Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 also may be related to tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

A platinum@polymer-catechol nanobraker enables radio-immunotherapy for crippling melanoma tumorigenesis, angiogenesis, and radioresistance.

Bioactive materials

Li W,Yan J,Tian H,Li B,Wang G,Sang W,Zhang Z,Zhang X,Dai Y

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2023

Exercise combined with administration of adipose-derived stem cells ameliorates neuropathic pain after spinal cord injury.

Neural regeneration research

Cheng X,Mao GP,Hu WJ,Yu ZR,Xu YY,Chen W,Li X,Zeng XL,Zhang WW,Chen JW,Wan Y,Wang L

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

Regulatory T-cells and IL-5 mediate pain outcomes in a preclinical model of chronic muscle pain.

Molecular pain

Lenert ME,Szabo-Pardi TA,Burton MD

47-0441-82 was used in Flow cytometry/Cell sorting to provide novel evidence that downregulation of regulatory T-cells play a role in chronic muscle pain pathology in the acidic saline model of FM and that IL-5 signaling is a promising target for future development of therapeutics.

Mon Feb 13 00:00:00 EST 2023

HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease.

JCI insight

Little AJ,Chen PM,Vesely MD,Khan RN,Fiedler J,Garritano J,Maisha FI,McNiff JM,Craft J

47-0441-82 was used in Flow cytometry/Cell sorting to demonstrate in human CLE tissue that the T cell-rich inflammatory infiltrate exhibited increased amounts of HIF-1 and a cytotoxic signature.

Tue Aug 22 00:00:00 EDT 2023

Egr2 and 3 maintain anti-tumour responses of exhausted tumour infiltrating CD8 + T cells.

Cancer immunology, immunotherapy : CII

Symonds ALJ,Miao T,Busharat Z,Li S,Wang P

47-0441-82 was used in Flow cytometry/Cell sorting to conclude that Egr2 and 3 are important for maintaining anti-tumour responses of exhausted CD8 + TILs.

Mon May 01 00:00:00 EDT 2023

Platelet factors attenuate inflammation and rescue cognition in ageing.

Nature

Schroer AB,Ventura PB,Sucharov J,Misra R,Chui MKK,Bieri G,Horowitz AM,Smith LK,Encabo K,Tenggara I,Couthouis J,Gross JD,Chan JM,Luke A,Villeda SA

47-0441-82 was used in Flow cytometry/Cell sorting to show that platelet factors transfer the benefits of young blood to the ageing brain.

Tue Aug 01 00:00:00 EDT 2023

TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.

Frontiers in immunology

O'Neill TJ,Gewies A,Seeholzer T,Krappmann D

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Feb 13 00:00:00 EST 2023

CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.

The Journal of clinical investigation

Sato Y,Oguchi A,Fukushima Y,Masuda K,Toriu N,Taniguchi K,Yoshikawa T,Cui X,Kondo M,Hosoi T,Komidori S,Shimizu Y,Fujita H,Jiang L,Kong Y,Yamanashi T,Seita J,Yamamoto T,Toyokuni S,Hamazaki Y,Hattori M,Yoshikai Y,Boor P,Floege J,Kawamoto H,Murakawa Y,Minato N,Yanagita M

47-0441-82 was used in Flow Cytometry to reveal a previously unappreciated function of CD153/CD30 signaling in TLT formation and propose targeting the CD153/CD30 signaling pathway as a therapeutic target for slowing kidney disease progression.

Tue Jan 18 00:00:00 EST 2022

CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.

The Journal of clinical investigation

Tue Jan 18 00:00:00 EST 2022

FUS-DDIT3 Fusion Oncoprotein Expression Affects JAK-STAT Signaling in Myxoid Liposarcoma.

Frontiers in oncology

Dolatabadi S,Jonasson E,Andersson L,Luna Santamaría M,Lindén M,Österlund T,Åman P,Ståhlberg A

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Feb 23 00:00:00 EST 2022

LncRNA ANRIL-mediated miR-181b-5p/S1PR1 axis is involved in the progression of uremic cardiomyopathy through activating T cells.

Scientific reports

Xu Y,Cao L,Ji S,Shen W

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Oct 27 00:00:00 EDT 2022

Isolation and characterization mesenchymal stem cells from red panda (Ailurus fulgens styani) endometrium.

Conservation physiology

Wang DH,Wu XM,Chen JS,Cai ZG,An JH,Zhang MY,Li Y,Li FP,Hou R,Liu YL

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Sat Jan 01 00:00:00 EST 2022

WDR82-binding long noncoding RNA lncEry controls mouse erythroid differentiation and maturation.

The Journal of experimental medicine

Yang S,Sun G,Wu P,Chen C,Kuang Y,Liu L,Zheng Z,He Y,Gu Q,Lu T,Zhu C,Wang F,Gou F,Yang Z,Zhao X,Yuan S,Yang L,Lu S,Li Y,Lv X,Dong F,Ma Y,Yu J,Ng LG,Shi L,Liu J,Shi L,Cheng T,Cheng H

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Apr 04 00:00:00 EDT 2022

Multivalent state transitions shape the intratumoral composition of small cell lung carcinoma.

Science advances

Gopal P,Petty A,Rogacki K,Bera T,Bareja R,Peacock CD,Abazeed ME

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Dec 14 00:00:00 EST 2022

Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression.

Nature communications

Qi M,Xia Y,Wu Y,Zhang Z,Wang X,Lu L,Dai C,Song Y,Xu K,Ji W,Zhan L

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Feb 16 00:00:00 EST 2022

RNF4~RGMb~BMP6 axis required for osteogenic differentiation and cancer cell survival.

Cell death & disease

Novak R,Ahmad YA,Timaner M,Bitman-Lotan E,Oknin-Vaisman A,Horwitz R,Hartmann O,Reissland M,Buck V,Rosenfeldt M,Nikomarov D,Diefenbacher ME,Shaked Y,Orian A

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Sat Sep 24 00:00:00 EDT 2022

CD44 Promotes Breast Cancer Metastasis through AKT-Mediated Downregulation of Nuclear FOXA2.

Biomedicines

Vadhan A,Hou MF,Vijayaraghavan P,Wu YC,Hu SC,Wang YM,Cheng TL,Wang YY,Yuan SF

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Oct 05 00:00:00 EDT 2022

Circ_RNF13 Regulates the Stemness and Chemosensitivity of Colorectal Cancer by Transcriptional Regulation of DDX27 Mediated by TRIM24 Stabilization.

Cancers

Guo Y,Hu G,Tian B,Ma M,Long F,Chen M

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Dec 16 00:00:00 EST 2022

Smad4 and p53 synergize in suppressing autochthonous intestinal cancer.

Cancer medicine

Park JW,Seo MJ,Cho KS,Kook MC,Jeong JM,Roh SG,Cho SY,Cheon JH,Kim HK

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2022

Amphiphile-CpG vaccination induces potent lymph node activation and COVID-19 immunity in mice and non-human primates.

NPJ vaccines

Seenappa LM,Jakubowski A,Steinbuck MP,Palmer E,Haqq CM,Carter C,Fontenot J,Villinger F,McNeil LK,DeMuth PC

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Oct 28 00:00:00 EDT 2022

Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain.

eLife

Kovacs MA,Cowan MN,Babcock IW,Sibley LA,Still K,Batista SJ,Labuzan SA,Sethi I,Harris TH

47-0441-82 was used in Flow cytometry/Cell sorting to reveal that CNS lymphatic drainage supports the development of peripheral T cell responses against T. gondii but remains dispensable for immune protection of the brain.

Wed Dec 21 00:00:00 EST 2022

NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.

Nature immunology

Gu M,Zhou X,Sohn JH,Zhu L,Jie Z,Yang JY,Zheng X,Xie X,Yang J,Shi Y,Brightbill HD,Kim JB,Wang J,Cheng X,Sun SC

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Disruption of the MSL complex inhibits tumour maintenance by exacerbating chromosomal instability.

Nature cell biology

Monserrat J,Morales Torres C,Richardson L,Wilson TS,Patel H,Domart MC,Horswell S,Song OR,Jiang M,Crawford M,Bui M,Dalal Y,Scaffidi P

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Apr 01 00:00:00 EDT 2021

A TLR7 antagonist restricts interferon-dependent and -independent immunopathology in a mouse model of severe influenza.

The Journal of experimental medicine

Rappe JCF,Finsterbusch K,Crotta S,Mack M,Priestnall SL,Wack A

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Nov 01 00:00:00 EDT 2021

Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.

The Journal of experimental medicine

Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Aug 02 00:00:00 EDT 2021

Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells.

The Journal of experimental medicine

Hosokawa H,Koizumi M,Masuhara K,Romero-Wolf M,Tanaka T,Nakayama T,Rothenberg EV

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Aug 02 00:00:00 EDT 2021

Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccination.

EMBO molecular medicine

Müller K,Gibbins MP,Roberts M,Reyes-Sandoval A,Hill AVS,Draper SJ,Matuschewski K,Silvie O,Hafalla JCR

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Apr 09 00:00:00 EDT 2021

Senescent T Cell Induces Brown Adipose Tissue "Whitening" Via Secreting IFN-γ.

Frontiers in cell and developmental biology

Pan XX,Yao KL,Yang YF,Ge Q,Zhang R,Gao PJ,Ruan CC,Wu F

47-0441 was used in Flow cytometry/Cell sorting to show the phenomenon of brown adipose tissue 'whitening' in old mice, induced by IFN-γ secretion by senescent T cells.

Tue Mar 23 00:00:00 EDT 2021

Senescent T Cell Induces Brown Adipose Tissue "Whitening" Via Secreting IFN-γ.

Frontiers in cell and developmental biology

Pan XX,Yao KL,Yang YF,Ge Q,Zhang R,Gao PJ,Ruan CC,Wu F

47-0441 was used in Flow cytometry/Cell sorting to show the phenomenon of brown adipose tissue 'whitening' in old mice, induced by IFN-γ secretion by senescent T cells.

Tue Mar 23 00:00:00 EDT 2021

Trichinella spiralis Paramyosin Induces Colonic Regulatory T Cells to Mitigate Inflammatory Bowel Disease.

Frontiers in cell and developmental biology

Hao C,Wang W,Zhan B,Wang Z,Huang J,Sun X,Zhu X

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Aug 03 00:00:00 EDT 2021

Downregulation of SLC27A6 by DNA Hypermethylation Promotes Proliferation but Suppresses Metastasis of Nasopharyngeal Carcinoma Through Modulating Lipid Metabolism.

Frontiers in oncology

Zhong X,Yang Y,Li B,Liang P,Huang Y,Zheng Q,Wang Y,Xiao X,Mo Y,Zhang Z,Zhou X,Huang G,Zhao W

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Jan 21 00:00:00 EST 2022

Thrombospondin-2 spatiotemporal expression in skeletal fractures.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Zondervan RL,Jenkins DC,Reicha JD,Hankenson KD

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2021

Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy.

Frontiers in immunology

Agalave NM,Mody PH,Szabo-Pardi TA,Jeong HS,Burton MD

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Sep 20 00:00:00 EDT 2021

Prophylactic efficacy against Mycobacterium tuberculosis using ID93 and lipid-based adjuvant formulations in the mouse model.

PloS one

Baldwin SL,Reese VA,Larsen SE,Beebe E,Guderian J,Orr MT,Fox CB,Reed SG,Coler RN

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Oct 13 00:00:00 EDT 2021

In Vitro Anti-cancer Activity of Adipose-Derived Mesenchymal Stem Cells Increased after Infection with Oncolytic Reovirus.

Advanced pharmaceutical bulletin

Babaei A,Bannazadeh Baghi H,Nezhadi A,Jamalpoor Z

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Valproic acid stimulates myogenesis in pluripotent stem cell-derived mesodermal progenitors in a NOTCH-dependent manner.

Cell death & disease

Breuls N,Giarratana N,Yedigaryan L,Garrido GM,Carai P,Heymans S,Ranga A,Deroose C,Sampaolesi M

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Jul 05 00:00:00 EDT 2021

miR-34a mimic or pre-mir-34a, which is the better option for cancer therapy? KatoIII as a model to study miRNA action in human gastric cancer cells.

Cancer cell international

Jafari N,Abediankenari S,Hossein-Nataj H

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Mar 19 00:00:00 EDT 2021

PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8⁺ T cells at the expense of central memory.

Cell reports

Cannons JL,Villarino AV,Kapnick SM,Preite S,Shih HY,Gomez-Rodriguez J,Kaul Z,Shibata H,Reilley JM,Huang B,Handon R,McBain IT,Gossa S,Wu T,Su HC,McGavern DB,O'Shea JJ,McGuire PJ,Uzel G,Schwartzberg PL

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Oct 12 00:00:00 EDT 2021

MiR-125b-5p Is Involved in Sorafenib Resistance through Ataxin-1-Mediated Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma.

Cancers

Hirao A,Sato Y,Tanaka H,Nishida K,Tomonari T,Hirata M,Bando M,Kida Y,Tanaka T,Kawaguchi T,Wada H,Taniguchi T,Okamoto K,Miyamoto H,Muguruma N,Tanahashi T,Takayama T

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression.

iScience

AbuEid M,McAllister DM,McOlash L,Harwig MC,Cheng G,Drouillard D,Boyle KA,Hardy M,Zielonka J,Johnson BD,Hill RB,Kalyanaraman B,Dwinell MB

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Jun 25 00:00:00 EDT 2021

Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis.

Nature communications

Li H,Wang M,Huang B,Zhu SW,Zhou JJ,Chen DR,Cui R,Zhang M,Sun ZJ

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Dec 09 00:00:00 EST 2021

Therapeutic Potential of Mesenchymal Stem Cells in a Pre-Clinical Model of Diabetic Kidney Disease and Obesity.

International journal of molecular sciences

Sávio-Silva C,Soinski-Sousa PE,Simplício-Filho A,Bastos RMC,Beyerstedt S,Rangel ÉB

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Feb 04 00:00:00 EST 2021

Attenuation of apoptotic cell detection triggers thymic regeneration after damage.

Cell reports

Kinsella S,Evandy CA,Cooper K,Iovino L,deRoos PC,Hopwo KS,Granadier DW,Smith CW,Rafii S,Dudakov JA

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Oct 05 00:00:00 EDT 2021

Protocols for isolation and characterization of mouse placental hemogenic endothelial cells.

STAR protocols

Liang G,Huang B,Wang F,Liu F

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Dec 17 00:00:00 EST 2021

Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.

EBioMedicine

Okada R,Furusawa A,Vermeer DW,Inagaki F,Wakiyama H,Kato T,Nagaya T,Choyke PL,Spanos WC,Allen CT,Kobayashi H

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

3-hydroxyanthranic acid increases the sensitivity of hepatocellular carcinoma to sorafenib by decreasing tumor cell stemness.

Cell death discovery

Gan G,Shi Z,Liu D,Zhang S,Zhu H,Wang Y,Mi J

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Jul 06 00:00:00 EDT 2021

A CD10-OGP Membrane Peptolytic Signaling Axis in Fibroblasts Regulates Lipid Metabolism of Cancer Stem Cells via SCD1.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Yu S,Lu Y,Su A,Chen J,Li J,Zhou B,Liu X,Xia Q,Li Y,Li J,Huang M,Ye Y,Zhao Q,Jiang S,Yan X,Wang X,Di C,Pan J,Su S

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Oct 01 00:00:00 EDT 2021

Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid.

The Journal of biological chemistry

Zhao Y,Cheng R,Zhao Y,Ge W,Yang Y,Ding Z,Xu X,Wang Z,Wu Z,Zhang J

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Oct 01 00:00:00 EDT 2021

A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.

Nature communications

Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure.

Cell death & disease

Yu H,Yang W,Huang J,Miao X,Wang B,Ren X,Gu Y,Wang Q,Ding X,Guo X,Qian F,Zhang Y,Xu H,Zheng L,Jin M

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Dec 16 00:00:00 EST 2021

Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.

Frontiers in immunology

Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Jan 11 00:00:00 EST 2022

Intestinal CD11b⁺ B Cells Ameliorate Colitis by Secreting Immunoglobulin A.

Frontiers in immunology

Fu Y,Wang Z,Yu B,Lin Y,Huang E,Liu R,Zhao C,Lu M,Xu W,Liu H,Liu Y,Wang L,Chu Y

47-0441-82 was used in Flow Cytometry to demonstrate that CD11b+ B cells are essential intestinal suppressive immune cells and the primary source of intestinal IgA, which plays an indispensable role in maintaining intestinal homeostasis.

Fri Jan 07 00:00:00 EST 2022

Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity.

Cell

Giampazolias E,Schulz O,Lim KHJ,Rogers NC,Chakravarty P,Srinivasan N,Gordon O,Cardoso A,Buck MD,Poirier EZ,Canton J,Zelenay S,Sammicheli S,Moncaut N,Varsani-Brown S,Rosewell I,Reis e Sousa C

47-0441-82 was used in Flow Cytometry to reveal a natural barrier to cross-presentation of cancer antigens that dampens anti-tumor CD8+ T cell responses.

Thu Jul 22 00:00:00 EDT 2021

Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.

STAR protocols

Skordos I,Demeyer A,Beyaert R

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Mar 19 00:00:00 EDT 2021

Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.

Immunity

Bonavita E,Bromley CP,Jonsson G,Pelly VS,Sahoo S,Walwyn-Brown K,Mensurado S,Moeini A,Flanagan E,Bell CR,Chiang SC,Chikkanna-Gowda CP,Rogers N,Silva-Santos B,Jaillon S,Mantovani A,Reis e Sousa C,Guerra N,Davis DM,Zelenay S

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Dec 15 00:00:00 EST 2020

Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.

Immunity

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Dec 15 00:00:00 EST 2020

Developmental Relationships of Four Exhausted CD8⁺ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms.

Immunity

Beltra JC,Manne S,Abdel-Hakeem MS,Kurachi M,Giles JR,Chen Z,Casella V,Ngiow SF,Khan O,Huang YJ,Yan P,Nzingha K,Xu W,Amaravadi RK,Xu X,Karakousis GC,Mitchell TC,Schuchter LM,Huang AC,Wherry EJ

47-0441-82 was used in Flow cytometry/Cell sorting to reveal a four-stage developmental hierarchy for Tex cells and define the molecular, transcriptional, and epigenetic mechanisms that could provide opportunities to improve cancer immunotherapy.

Tue May 19 00:00:00 EDT 2020

Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4⁺ T Cell Pathogenicity and Suppresses Autoimmunity.

Cell metabolism

Angiari S,Runtsch MC,Sutton CE,Palsson-McDermott EM,Kelly B,Rana N,Kane H,Papadopoulou G,Pearce EL,Mills KHG,O'Neill LAJ

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Feb 04 00:00:00 EST 2020

Transfer of metastatic traits via miR-200c in extracellular vesicles derived from colorectal cancer stem cells is inhibited by atractylenolide I.

Clinical and translational medicine

Tang D,Xu X,Ying J,Xie T,Cao G

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Sat Aug 01 00:00:00 EDT 2020

Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling.

PLoS pathogens

Still KM,Batista SJ,O'Brien CA,Oyesola OO,Früh SP,Webb LM,Smirnov I,Kovacs MA,Cowan MN,Hayes NW,Thompson JA,Tait Wojno ED,Harris TH

47-0441 was used in Flow cytometry/Cell sorting to show that IL-33 is expressed by oligodendrocytes and astrocytes during T. gondii infection, is released locally into the cerebrospinal fluid of T. gondii-infected animals, and is required for control of infection.

Thu Oct 01 00:00:00 EDT 2020

Distinct roles of PIK3CA in the enrichment and maintenance of cancer stem cells in head and neck squamous cell carcinoma.

Molecular oncology

Chen X,Cao Y,Sedhom W,Lu L,Liu Y,Wang H,Oka M,Bornstein S,Said S,Song J,Lu SL

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

Down-Regulated Exosomal MicroRNA-221 - 3p Derived From Senescent Mesenchymal Stem Cells Impairs Heart Repair.

Frontiers in cell and developmental biology

Sun L,Zhu W,Zhao P,Zhang J,Lu Y,Zhu Y,Zhao W,Liu Y,Chen Q,Zhang F

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Dexamethasone inhibits stemness maintenance and enhances chemosensitivity of hepatocellular carcinoma stem cells by inducing deSUMOylation of HIF‑1α and Oct4.

International journal of oncology

Jiang Z,Zhang C,Liu X,Ma X,Bian X,Xiao X,Gao R,Sun Y,Wu W,Zhao P

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2020

Extracellular HMGB-1 activates inflammatory signaling in tendon cells and tissues.

Therapeutic advances in chronic disease

Zhang C,Gu X,Zhao G,Wang W,Shao J,Zhu J,Yuan T,Sun J,Nie D,Zhou Y

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Sun Apr 17 00:00:00 EDT 2022

miR‑210 enhances mesenchymal stem cell‑modulated neural precursor cell migration.

Molecular medicine reports

Wang F,Zhu J,Zheng J,Duan W,Zhou Z

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2020

Identification, characterization and microRNA expression profiling of side population cells in human oral squamous cell carcinoma Tca8113 cell lines.

Molecular medicine reports

Luo W,Liu RS,E LL,Bai Y,Kong XP,Liu HW,Wu H,Liu HC

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2020

Resveratrol rescues TNF‑α‑induced inhibition of osteogenesis in human periodontal ligament stem cells via the ERK1/2 pathway.

Molecular medicine reports

Yuan J,Wang X,Ma D,Gao H,Zheng D,Zhang J

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2020

Critical role of WNK1 in MYC-dependent early mouse thymocyte development.

eLife

Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Oct 14 00:00:00 EDT 2020

Critical role of WNK1 in MYC-dependent early mouse thymocyte development.

eLife

Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Oct 14 00:00:00 EDT 2020

Effect of Combining Low Temperature Plasma, Negative Pressure Wound Therapy, and Bone Marrow Mesenchymal Stem Cells on an Acute Skin Wound Healing Mouse Model.

International journal of molecular sciences

Cui HS,Joo SY,Cho YS,Park JH,Kim JB,Seo CH

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Sat May 23 00:00:00 EDT 2020

Targeted expression profiling reveals distinct stages of early canine fibroblast reprogramming are regulated by 2-oxoglutarate hydroxylases.

Stem cell research & therapy

Tobias IC,Kao MC,Parmentier T,Hunter H,LaMarre J,Betts DH

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Dec 09 00:00:00 EST 2020

Chemotherapeutic Stress Influences Epithelial-Mesenchymal Transition and Stemness in Cancer Stem Cells of Triple-Negative Breast Cancer.

International journal of molecular sciences

Li X,Strietz J,Bleilevens A,Stickeler E,Maurer J

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Jan 08 00:00:00 EST 2020

Inhibition of EZH2 ameliorates bacteria-induced liver injury by repressing RUNX1 in dendritic cells.

Cell death & disease

Wang Y,Wang Q,Wang B,Gu Y,Yu H,Yang W,Ren X,Qian F,Zhao X,Xiao Y,Zhang Y,Jin M,Zhu M

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Tumor Cell Associated Hyaluronan-CD44 Signaling Promotes Pro-Tumor Inflammation in Breast Cancer.

Cancers

Witschen PM,Chaffee TS,Brady NJ,Huggins DN,Knutson TP,LaRue RS,Munro SA,Tiegs L,McCarthy JB,Nelson AC,Schwertfeger KL

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri May 22 00:00:00 EDT 2020

Utility Evaluation of Porcine Enteroids as PDCoV Infection Model in vitro.

Frontiers in microbiology

Luo H,Zheng J,Chen Y,Wang T,Zhang Z,Shan Y,Xu J,Yue M,Fang W,Li X

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Head and Neck Cancer Stem Cell-Enriched Spheroid Model for Anticancer Compound Screening.

Cells

Goričan L,Gole B,Potočnik U

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Jul 16 00:00:00 EDT 2020

Obesity-Altered Adipose Stem Cells Promote Radiation Resistance of Estrogen Receptor Positive Breast Cancer through Paracrine Signaling.

International journal of molecular sciences

Sabol RA,Villela VA,Denys A,Freeman BT,Hartono AB,Wise RM,Harrison MAA,Sandler MB,Hossain F,Miele L,Bunnell BA

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Apr 15 00:00:00 EDT 2020

CCL5 derived from tumor-associated macrophages promotes prostate cancer stem cells and metastasis via activating β-catenin/STAT3 signaling.

Cell death & disease

Huang R,Wang S,Wang N,Zheng Y,Zhou J,Yang B,Wang X,Zhang J,Guo L,Wang S,Chen Z,Wang Z,Xiang S

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Apr 16 00:00:00 EDT 2020

Profiling and Targeting of Energy and Redox Metabolism in Grade 2 Bladder Cancer Cells with Different Invasiveness Properties.

Cells

Pasquale V,Ducci G,Campioni G,Ventrici A,Assalini C,Busti S,Vanoni M,Vago R,Sacco E

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Dec 11 00:00:00 EST 2020

Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals.

Cell & bioscience

Jiang M,Ye J,Wang X,Li N,Wang Y,Shi Y

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Apr 14 00:00:00 EDT 2022

Requirements for the differentiation of innate T-bet^high memory-phenotype CD4⁺ T lymphocytes under steady state.

Nature communications

Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Jul 06 00:00:00 EDT 2020

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.

JCI insight

Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A

47-0441 was used in Flow cytometry/Cell sorting to study can serve as a foundation for trials testing immunotherapeutic approaches in patients with ovarian GCT.

Thu Aug 20 00:00:00 EDT 2020

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.

Nature communications

Toubal A,Kiaf B,Beaudoin L,Cagninacci L,Rhimi M,Fruchet B,da Silva J,Corbett AJ,Simoni Y,Lantz O,Rossjohn J,McCluskey J,Lesnik P,Maguin E,Lehuen A

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Jul 24 00:00:00 EDT 2020

Localized cocktail chemoimmunotherapy after in situ gelation to trigger robust systemic antitumor immune responses.

Science advances

Chao Y,Liang C,Tao H,Du Y,Wu D,Dong Z,Jin Q,Chen G,Xu J,Xiao Z,Chen Q,Wang C,Chen J,Liu Z

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2020

A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation.

Circulation research

Lu X,Rudemiller NP,Wen Y,Ren J,Hammer GE,Griffiths R,Privratsky JR,Yang B,Sparks MA,Crowley SD

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Dec 06 00:00:00 EST 2019

A Novel Form of 4-1BBL Prevents Cancer Development via Nonspecific Activation of CD4⁺ T and Natural Killer Cells.

Cancer research

Barsoumian HB,Batra L,Shrestha P,Bowen WS,Zhao H,Egilmez NK,Gomez-Gutierrez JG,Yolcu ES,Shirwan H

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Feb 15 00:00:00 EST 2019

Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice.

Genome research

Alriyami M,Marchand L,Li Q,Du X,Olivier M,Polychronakos C

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Sun Dec 01 00:00:00 EST 2019

PTCy ameliorates GVHD by restoring regulatory and effector T-cell homeostasis in recipients with PD-1 blockade.

Blood advances

Ikegawa S,Meguri Y,Kondo T,Sugiura H,Sando Y,Nakamura M,Iwamoto M,Maeda Y,Matsuoka KI

47-0441-82 was used in Flow Cytometry to present that the influence of PD-1 blockade differed within T-cell subsets and caused unbalanced reconstitution of T-cell subsets, resulting in severe GVHD. PTCy successfully restored T-cell homeostasis and ameliorated GVHD induced by PD-1-/- donor T cells.

Tue Dec 10 00:00:00 EST 2019

The ROP16III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival.

PLoS pathogens

Tuladhar S,Kochanowsky JA,Bhaskara A,Ghotmi Y,Chandrasekaran S,Koshy AA

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Anisomycin inhibits angiogenesis in ovarian cancer by attenuating the molecular sponge effect of the lncRNA‑Meg3/miR‑421/PDGFRA axis.

International journal of oncology

Ye W,Ni Z,Yicheng S,Pan H,Huang Y,Xiong Y,Liu T

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Sun Dec 01 00:00:00 EST 2019

Hypoxia changes chemotaxis behaviour of mesenchymal stem cells via HIF-1α signalling.

Journal of cellular and molecular medicine

Xu W,Xu R,Li Z,Wang Y,Hu R

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2019

Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro.

Stem cells international

Sun B,Luo X,Yang C,Liu P,Yang Y,Dong X,Yang Z,Xu J,Zhang Y,Li L

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu May 13 00:00:00 EDT 2021

HMGB3 silence inhibits breast cancer cell proliferation and tumor growth by interacting with hypoxia-inducible factor 1α.

Cancer management and research

Gu J,Xu T,Huang QH,Zhang CM,Chen HY

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Sep 29 00:00:00 EDT 2020

TGF‑β induces periodontal ligament stem cell senescence through increase of ROS production.

Molecular medicine reports

Fan C,Ji Q,Zhang C,Xu S,Sun H,Li Z

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Effects of demographic factors on adipogenic and chondrogenic differentiation in bone marrow-derived stem cells.

Experimental and therapeutic medicine

Lee H,Min SK,Park JB

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed May 01 00:00:00 EDT 2019

The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway.

EBioMedicine

Seo D,Jung SM,Park JS,Lee J,Ha J,Kim M,Park SH

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Nov 01 00:00:00 EDT 2019

BMX-ARHGAP fusion protein maintains the tumorigenicity of gastric cancer stem cells by activating the JAK/STAT3 signaling pathway.

Cancer cell international

Xu XF,Gao F,Wang JJ,Long C,Chen X,Tao L,Yang L,Ding L,Ji Y

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Apr 08 00:00:00 EDT 2022

BRCA1 regulates the cancer stem cell fate of breast cancer cells in the context of hypoxia and histone deacetylase inhibitors.

Scientific reports

Kim H,Lin Q,Yun Z

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Jul 04 00:00:00 EDT 2019

Visfatin Mediates Malignant Behaviors through Adipose-Derived Stem Cells Intermediary in Breast Cancer.

Cancers

Huang JY,Wang YY,Lo S,Tseng LM,Chen DR,Wu YC,Hou MF,Yuan SF

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Dec 20 00:00:00 EST 2019

Better therapeutic potential of bone marrow-derived mesenchymal stem cells compared with chorionic villi-derived mesenchymal stem cells in airway injury model.

Regenerative medicine

Ji S,Wu C,Tong L,Wang L,Zhou J,Chen C,Song Y

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2019

Overexpression of Aiolos promotes epithelial-mesenchymal transition and cancer stem cell-like properties in lung cancer cells.

Scientific reports

Hung JJ,Kao YS,Huang CH,Hsu WH

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Feb 28 00:00:00 EST 2019

Qa-1-Restricted CD8⁺ T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection.

Cell reports

Anderson CK,Reilly EC,Lee AY,Brossay L

47-0441 was used in Flow cytometry/Cell sorting to study compensatory mechanisms in immune responses to viruses when classical T cell immunity has been evaded.

Tue Apr 09 00:00:00 EDT 2019

Sex Differences in Mouse Popliteal Lymph Nodes.

Scientific reports

Dill-Garlow R,Chen KE,Walker AM

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Jan 30 00:00:00 EST 2019

ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.

Nature communications

Cao Y,Trillo-Tinoco J,Sierra RA,Anadon C,Dai W,Mohamed E,Cen L,Costich TL,Magliocco A,Marchion D,Klar R,Michel S,Jaschinski F,Reich RR,Mehrotra S,Cubillos-Ruiz JR,Munn DH,Conejo-Garcia JR,Rodriguez PC

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Mar 20 00:00:00 EDT 2019

Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair.

Cell reports

Colunga T,Hayworth M,Kreß S,Reynolds DM,Chen L,Nazor KL,Baur J,Singh AM,Loring JF,Metzger M,Dalton S

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Mar 05 00:00:00 EST 2019

MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner.

Frontiers in immunology

Demeyer A,Skordos I,Driege Y,Kreike M,Hochepied T,Baens M,Staal J,Beyaert R

47-0441 was used in Flow cytometry/Cell sorting to establish that suppression of autoimmune responses is due to the T-cell intrinsic role of MALT1 proteolytic activity.

Mon Oct 05 00:00:00 EDT 2020

Reprogramming the adjuvant properties of aluminum oxyhydroxide with nanoparticle technology.

NPJ vaccines

Orr MT,Khandhar AP,Seydoux E,Liang H,Gage E,Mikasa T,Beebe EL,Rintala ND,Persson KH,Ahniyaz A,Carter D,Reed SG,Fox CB

47-0441-82 was used in Flow Cytometry to determine whether the particle size and aggregated state of aluminum oxyhydroxide affects its adjuvant activity.

Thu Oct 01 00:00:00 EDT 2020

Growth Factor Screening in Dystrophic Muscles Reveals PDGFB/PDGFRB-Mediated Migration of Interstitial Stem Cells.

International journal of molecular sciences

Camps J,Grosemans H,Gijsbers R,Maes C,Sampaolesi M

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Mar 05 00:00:00 EST 2019

Conserved regulation of RNA processing in somatic cell reprogramming.

BMC genomics

Kanitz A,Syed AP,Kaji K,Zavolan M

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Jan 31 00:00:00 EST 2019

Intracellular delivery of mRNA to human primary T cells with microfluidic vortex shedding.

Scientific reports

Jarrell JA,Twite AA,Lau KHWJ,Kashani MN,Lievano AA,Acevedo J,Priest C,Nieva J,Gottlieb D,Pawell RS

47-0441 was used in Flow cytometry/Cell sorting to show microfluidic vortex shedding mediates intracellular delivery of mRNA into primary human T lymphocytes.

Fri Mar 01 00:00:00 EST 2019

Bryostatin-1 alleviates experimental multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM

47-0441 was used in Flow cytometry/Cell sorting to study the effects of bryostatin-1 on the pathology of murine experimental autoimmune encephalomyelitis, with potential applications in progressive forms of multiple sclerosis.

Tue Feb 27 00:00:00 EST 2018

Bryostatin-1 alleviates experimental multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM

Tue Feb 27 00:00:00 EST 2018

CD4⁺ T Cell Fate Decisions Are Stochastic, Precede Cell Division, Depend on GITR Co-Stimulation, and Are Associated With Uropodium Development.

Frontiers in immunology

Cobbold SP,Adams E,Howie D,Waldmann H

47-0441 was used in Flow cytometry/Cell sorting to develop an in vitro model of T cell differentiation suited to testing how manipulation of components of the microenvironment might be therapeutically exploited.

Mon Jan 31 00:00:00 EST 2022

Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.

Oncogene

Solomon H,Dinowitz N,Pateras IS,Cooks T,Shetzer Y,Molchadsky A,Charni M,Rabani S,Koifman G,Tarcic O,Porat Z,Kogan-Sakin I,Goldfinger N,Oren M,Harris CC,Gorgoulis VG,Rotter V

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Mar 01 00:00:00 EST 2018

The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells.

Breast cancer research : BCR

Kim H,Lin Q,Glazer PM,Yun Z

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Mar 06 00:00:00 EST 2018

SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer.

The Journal of cell biology

Viotti M,Wilson C,McCleland M,Koeppen H,Haley B,Jhunjhunwala S,Klijn C,Modrusan Z,Arnott D,Classon M,Stephan JP,Mellman I

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Feb 05 00:00:00 EST 2018

Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43.

Experimental and therapeutic medicine

Li Z,Zhang S,Cao L,Li W,Ye YC,Shi ZX,Wang ZR,Sun LX,Wang JW,Jia LT,Wang W

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

mTOR Modulates CD8+ T Cell Differentiation in Mice with Invasive Pulmonary Aspergillosis.

Open life sciences

Wang H,Xiao Y,Su L,Cui N,Liu D

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Jan 01 00:00:00 EST 2018

Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.

Nature communications

Sun C,Lan P,Han Q,Huang M,Zhang Z,Xu G,Song J,Wang J,Wei H,Zhang J,Sun R,Zhang C,Tian Z

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Mar 28 00:00:00 EDT 2018

Inhibition of Fas associated phosphatase 1 (Fap1) facilitates apoptosis of colon cancer stem cells and enhances the effects of oxaliplatin.

Oncotarget

Huang W,Bei L,Eklund EA

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri May 25 00:00:00 EDT 2018

An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer.

eLife

Li J,Choi PS,Chaffer CL,Labella K,Hwang JH,Giacomelli AO,Kim JW,Ilic N,Doench JG,Ly SH,Dai C,Hagel K,Hong AL,Gjoerup O,Goel S,Ge JY,Root DE,Zhao JJ,Brooks AN,Weinberg RA,Hahn WC

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Jul 30 00:00:00 EDT 2018

Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.

Nature communications

Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Nov 08 00:00:00 EST 2018

RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.

The Journal of biological chemistry

Ge J,Burnier L,Adamopoulou M,Kwa MQ,Schaks M,Rottner K,Brakebusch C

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Jun 15 00:00:00 EDT 2018

Selective Export into Extracellular Vesicles and Function of tRNA Fragments during T Cell Activation.

Cell reports

Chiou NT,Kageyama R,Ansel KM

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Dec 18 00:00:00 EST 2018

Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.

Cancer cell

Turaj AH,Hussain K,Cox KL,Rose-Zerilli MJJ,Testa J,Dahal LN,Chan HTC,James S,Field VL,Carter MJ,Kim HJ,West JJ,Thomas LJ,He LZ,Keler T,Johnson PWM,Al-Shamkhani A,Thirdborough SM,Beers SA,Cragg MS,Glennie MJ,Lim SH

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Dec 11 00:00:00 EST 2017

Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.

Cell stem cell

Ruetz T,Pfisterer U,Di Stefano B,Ashmore J,Beniazza M,Tian TV,Kaemena DF,Tosti L,Tan W,Manning JR,Chantzoura E,Ottosson DR,Collombet S,Johnsson A,Cohen E,Yusa K,Linnarsson S,Graf T,Parmar M,Kaji K

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Dec 07 00:00:00 EST 2017

Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.

The Journal of clinical investigation

Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

The Journal of experimental medicine

Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Jun 05 00:00:00 EDT 2017

Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells.

Proceedings of the National Academy of Sciences of the United States of America

Bierie B,Pierce SE,Kroeger C,Stover DG,Pattabiraman DR,Thiru P,Liu Donaher J,Reinhardt F,Chaffer CL,Keckesova Z,Weinberg RA

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Mar 21 00:00:00 EDT 2017

Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8⁺ T-cell Differentiation during the Immune Response to Invasive Pulmonary Aspergillosis.

Chinese medical journal

Cui N,Wang H,Su LX,Zhang JH,Long Y,Liu DW

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Sat May 20 00:00:00 EDT 2017

The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice.

Journal of immunology (Baltimore, Md. : 1950)

Sitrin J,Suto E,Wuster A,Eastham-Anderson J,Kim JM,Austin CD,Lee WP,Behrens TW

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Aug 15 00:00:00 EDT 2017

A high-yield isolation and enrichment strategy for human lung microvascular endothelial cells.

Pulmonary circulation

Gaskill C,Majka SM

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Comparison of Four Protocols to Generate Chondrocyte-Like Cells from Human Induced Pluripotent Stem Cells (hiPSCs).

Stem cell reviews and reports

Suchorska WM,Augustyniak E,Richter M,Trzeciak T

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.

Scientific reports

Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Sep 29 00:00:00 EDT 2017

Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.

Nature communications

Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Oct 11 00:00:00 EDT 2017

Glutamic Pyruvate Transaminase GPT2 Promotes Tumorigenesis of Breast Cancer Cells by Activating Sonic Hedgehog Signaling.

Theranostics

Cao Y,Lin SH,Wang Y,Chin YE,Kang L,Mi J

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Apr 30 00:00:00 EDT 2018

IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.

JCI insight

Le Saout C,Luckey MA,Villarino AV,Smith M,Hasley RB,Myers TG,Imamichi H,Park JH,O'Shea JJ,Lane HC,Catalfamo M

47-0441 was used in Flow cytometry/Cell sorting to propose a model in which T cells undergoing lymphopenia-induced proliferation upregulate STAT1 protein, switching on an alternate IL-7-dependent program.

Thu Nov 16 00:00:00 EST 2017

SOCS3 treatment prevents the development of alopecia areata by inhibiting CD8+ T cell-mediated autoimmune destruction.

Oncotarget

Gao Z,Jin YQ,Wu W

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue May 16 00:00:00 EDT 2017

Extrafollicular CD4⁺ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.

Nature communications

Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

Extrafollicular CD4⁺ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.

Nature communications

Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB.

PloS one

Gao SY,Zheng GS,Wang L,Liang YJ,Zhang SE,Lao XM,Li K,Liao GQ

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Sep 18 00:00:00 EDT 2017

Oligodendrocyte death results in immune-mediated CNS demyelination.

Nature neuroscience

Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.

The Journal of experimental medicine

Drennan MB,Govindarajan S,Verheugen E,Coquet JM,Staal J,McGuire C,Taghon T,Leclercq G,Beyaert R,van Loo G,Lambrecht BN,Elewaut D

47-0441 was used in Flow cytometry/Cell sorting to show that negative regulation of TCR signalling during NKT development controls the differentiation and survival of NKT1 and NKT2 cells.

Mon Sep 19 00:00:00 EDT 2016

SOX2 and PI3K Cooperate to Induce and Stabilize a Squamous-Committed Stem Cell Injury State during Lung Squamous Cell Carcinoma Pathogenesis.

PLoS biology

Kim BR,Van de Laar E,Cabanero M,Tarumi S,Hasenoeder S,Wang D,Virtanen C,Suzuki T,Bandarchi B,Sakashita S,Pham NA,Lee S,Keshavjee S,Waddell TK,Tsao MS,Moghal N

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Nov 01 00:00:00 EDT 2016

Stem Cells Antigen-1 Enriches for a Cancer Stem Cell-Like Subpopulation in Mouse Gastric Cancer.

Stem cells (Dayton, Ohio)

Park JW,Park JM,Park DM,Kim DY,Kim HK

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.

Journal of immunology (Baltimore, Md. : 1950)

Menendez CM,Jinkins JK,Carr DJ

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Aug 15 00:00:00 EDT 2016

Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice.

Journal of immunology (Baltimore, Md. : 1950)

Sood S,Brownlie RJ,Garcia C,Cowan G,Salmond RJ,Sakaguchi S,Zamoyska R

47-0441 was used in Flow cytometry/Cell sorting to show that small perturbations in TCR signal transduction pathways can have profound consequences on T cell differentiation and the development of autoimmune disease.

Fri Jul 15 00:00:00 EDT 2016

Evaluation of the irritancy and hypersensitivity potential following topical application of didecyldimethylammonium chloride.

Journal of immunotoxicology

Anderson SE,Shane H,Long C,Lukomska E,Meade BJ,Marshall NB

47-0441 was used in Flow cytometry/Cell sorting to investigate the irritancy and hypersensivity potential of didecyldimethylammonium chloride (DDAC).

Fri Jul 01 00:00:00 EDT 2016

Effects of nerve growth factor and basic fibroblast growth factor dual gene modification on rat bone marrow mesenchymal stem cell differentiation into neuron-like cells in vitro.

Molecular medicine reports

Hu Y,Zhang Y,Tian K,Xun C,Wang S,Lv D

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Comparable roles of CD44v8-10 and CD44s in the development of bone metastases in a mouse model.

Oncology letters

Hiraga T,Nakamura H

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2016

Cryptotanshinone targets tumor-initiating cells through down-regulation of stemness genes expression.

Oncology letters

Zhang Y,Cabarcas SM,Zheng JI,Sun L,Mathews LA,Zhang X,Lin H,Farrar WL

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Jun 01 00:00:00 EDT 2016

PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.

Biology open

Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Sun May 15 00:00:00 EDT 2016

Sertoli cell condition medium can induce germ like cells from bone marrow derived mesenchymal stem cells.

Iranian journal of basic medical sciences

Monfared MH,Minaee B,Rastegar T,Khrazinejad E,Barbarestani M

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Nov 01 00:00:00 EDT 2016

A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.

Nature communications

Jeric I,Maurer G,Cavallo AL,Raguz J,Desideri E,Tarkowski B,Parrini M,Fischer I,Zatloukal K,Baccarini M

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Dec 21 00:00:00 EST 2016

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.

Nature communications

Brinkman CC,Iwami D,Hritzo MK,Xiong Y,Ahmad S,Simon T,Hippen KL,Blazar BR,Bromberg JS

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Jun 21 00:00:00 EDT 2016

The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states.

BMC biology

Toneff MJ,Sreekumar A,Tinnirello A,Hollander PD,Habib S,Li S,Ellis MJ,Xin L,Mani SA,Rosen JM

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Jun 17 00:00:00 EDT 2016

Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production.

Stem cell research & therapy

Camilleri ET,Gustafson MP,Dudakovic A,Riester SM,Garces CG,Paradise CR,Takai H,Karperien M,Cool S,Sampen HJ,Larson AN,Qu W,Smith J,Dietz AB,van Wijnen AJ

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Aug 11 00:00:00 EDT 2016

Adjuvanted multi-epitope vaccines protect HLA-A*11:01 transgenic mice against Toxoplasma gondii.

JCI insight

El Bissati K,Chentoufi AA,Krishack PA,Zhou Y,Woods S,Dubey JP,Vang L,Lykins J,Broderick KE,Mui E,Suzuki Y,Sa Q,Bi S,Cardona N,Verma SK,Fraczek L,Reardon CA,Sidney J,Alexander J,Sette A,Vedvick T,Fox C,Guderian JA,Reed S,Roberts CW,McLeod R

47-0441 was used in Flow cytometry/Cell sorting to develop multi-epitope DNA or protein vaccines with TLR4 ligand emulsion adjuvant to protect against Toxoplasma gondii.

Thu Sep 22 00:00:00 EDT 2016

Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages.

Scientific reports

Zhou P,Chionh YT,Irac SE,Ahn M,Jia Ng JH,Fossum E,Bogen B,Ginhoux F,Irving AT,Dutertre CA,Wang LF

47-0441 was used in Flow cytometry/Cell sorting to successfully generate bat bone marrow-derived DC and macrophages.

Fri Dec 09 00:00:00 EST 2016

Llgl1 prevents metaplastic survival driven by epidermal growth factor dependent migration.

Oncotarget

Greenwood E,Maisel S,Ebertz D,Russ A,Pandey R,Schroeder J

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Sep 20 00:00:00 EDT 2016

Cell surface galectin-3 defines a subset of chemoresistant gastrointestinal tumor-initiating cancer cells with heightened stem cell characteristics.

Cell death & disease

Ilmer M,Mazurek N,Byrd JC,Ramirez K,Hafley M,Alt E,Vykoukal J,Bresalier RS

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Aug 11 00:00:00 EDT 2016

Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle.

The Journal of clinical investigation

Quattrocelli M,Swinnen M,Giacomazzi G,Camps J,Barthélemy I,Ceccarelli G,Caluwé E,Grosemans H,Thorrez L,Pelizzo G,Muijtjens M,Verfaillie CM,Blot S,Janssens S,Sampaolesi M

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2015

Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.

Cancer research

Zhang S,Chung WC,Wu G,Egan SE,Miele L,Xu K

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri May 15 00:00:00 EDT 2015

Enrichment of Human Stem-Like Prostate Cells with s-SHIP Promoter Activity Uncovers a Role in Stemness for the Long Noncoding RNA H19.

Stem cells and development

Bauderlique-Le Roy H,Vennin C,Brocqueville G,Spruyt N,Adriaenssens E,Bourette RP

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri May 15 00:00:00 EDT 2015

Multi-Drug Resistance ABC Transporter Inhibition Enhances Murine Ventral Prostate Stem/Progenitor Cell Differentiation.

Stem cells and development

Samant MD,Jackson CM,Felix CL,Jones AJ,Goodrich DW,Foster BA,Huss WJ

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri May 15 00:00:00 EDT 2015

Special AT-rich sequence-binding protein-1 participates in the maintenance of breast cancer stem cells through regulation of the Notch signaling pathway and expression of Snail1 and Twist1.

Molecular medicine reports

Sun Z,Zhang C,Zou X,Jiang G,Xu Z,Li W,Xie H

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2015

Reprogramming Roadblocks Are System Dependent.

Stem cell reports

Chantzoura E,Skylaki S,Menendez S,Kim SI,Johnsson A,Linnarsson S,Woltjen K,Chambers I,Kaji K

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Sep 08 00:00:00 EDT 2015

Multi-lineage differentiation of human umbilical cord Wharton's Jelly Mesenchymal Stromal Cells mediates changes in the expression profile of stemness markers.

PloS one

Ali H,Al-Yatama MK,Abu-Farha M,Behbehani K,Al Madhoun A

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Mar 25 00:00:00 EDT 2016

MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation.

Stem cell reports

Tan Y,AlKhamees B,Jia D,Li L,Couture JF,Figeys D,Jinushi M,Wang L

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Nov 10 00:00:00 EST 2015

Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spatial learning and memory in mouse middle cerebral artery occlusion model.

Stem cell research & therapy

Zhou F,Gao S,Wang L,Sun C,Chen L,Yuan P,Zhao H,Yi Y,Qin Y,Dong Z,Cao L,Ren H,Zhu L,Li Q,Lu B,Liang A,Xu GT,Zhu H,Gao Z,Ma J,Xu J,Chen X

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Sat May 09 00:00:00 EDT 2015

The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.

Nature immunology

Salmond RJ,Brownlie RJ,Morrison VL,Zamoyska R

47-0441 was used in Flow cytometry/Cell sorting to study how loss-of-function PTPN22 alleles can lead to the population expansion of effector and/or memory T cells and a predisposition to human autoimmunity.

Mon Sep 01 00:00:00 EDT 2014

Intravascular staining for discrimination of vascular and tissue leukocytes.

Nature protocols

Anderson KG,Mayer-Barber K,Sung H,Beura L,James BR,Taylor JJ,Qunaj L,Griffith TS,Vezys V,Barber DL,Masopust D

47-0441 was used in Flow cytometry/Cell sorting to outline a protocol for the validation and use of intravascular staining to define innate and adaptive immune cells in mice.

Wed Jan 01 00:00:00 EST 2014

Serum- and growth-factor-free three-dimensional culture system supports cartilage tissue formation by promoting collagen synthesis via Sox9-Col2a1 interaction.

Tissue engineering. Part A

Ahmed N,Iu J,Brown CE,Taylor DW,Kandel RA

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Aug 01 00:00:00 EDT 2014

Tumor-suppressive activity of Lunatic Fringe in prostate through differential modulation of Notch receptor activation.

Neoplasia (New York, N.Y.)

Zhang S,Chung WC,Wu G,Egan SE,Xu K

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Sat Feb 01 00:00:00 EST 2014

FOXF1 mediates mesenchymal stem cell fusion-induced reprogramming of lung cancer cells.

Oncotarget

Wei HJ,Nickoloff JA,Chen WH,Liu HY,Lo WC,Chang YT,Yang PC,Wu CW,Williams DF,Gelovani JG,Deng WP

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Wed Oct 15 00:00:00 EDT 2014

Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.

PloS one

Xiao GY,Liu IH,Cheng CC,Chang CC,Lee YH,Cheng WT,Wu SC

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu May 28 00:00:00 EDT 2015

Validation of the effects of TGF-β1 on tumor recurrence and prognosis through tumor retrieval and cell mechanical properties.

Cancer cell international

Wu TH,Chou YW,Chiu PH,Tang MJ,Hu CW,Yeh ML

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Mar 03 00:00:00 EST 2014

High-resolution analysis with novel cell-surface markers identifies routes to iPS cells.

Nature

O'Malley J,Skylaki S,Iwabuchi KA,Chantzoura E,Ruetz T,Johnsson A,Tomlinson SR,Linnarsson S,Kaji K

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Jul 04 00:00:00 EDT 2013

miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.

Nature cell biology

Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2013

GATA3 suppresses metastasis and modulates the tumour microenvironment by regulating microRNA-29b expression.

Nature cell biology

Chou J,Lin JH,Brenot A,Kim JW,Provot S,Werb Z

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2013

Inhibiting interactions of lysine demethylase LSD1 with snail/slug blocks cancer cell invasion.

Cancer research

Ferrari-Amorotti G,Fragliasso V,Esteki R,Prudente Z,Soliera AR,Cattelani S,Manzotti G,Grisendi G,Dominici M,Pieraccioli M,Raschellà G,Chiodoni C,Colombo MP,Calabretta B

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2013

Evidence for a multipotent mammary progenitor with pregnancy-specific activity.

Breast cancer research : BCR

Kaanta AS,Virtanen C,Selfors LM,Brugge JS,Neel BG

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Dec 08 00:00:00 EST 2014

Persistent enteric murine norovirus infection is associated with functionally suboptimal virus-specific CD8 T cell responses.

Journal of virology

Tomov VT,Osborne LC,Dolfi DV,Sonnenberg GF,Monticelli LA,Mansfield K,Virgin HW,Artis D,Wherry EJ

47-0441 was used in Flow cytometry/Cell sorting to investigate the magnitude, location, and dynamics of the murine norovirus-specific immune response.

Sat Jun 01 00:00:00 EDT 2013

The CD44+ ALDH+ population of human keratinocytes is enriched for epidermal stem cells with long-term repopulating ability.

Stem cells (Dayton, Ohio)

Szabo AZ,Fong S,Yue L,Zhang K,Strachan LR,Scalapino K,Mancianti ML,Ghadially R

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Apr 01 00:00:00 EDT 2013

Estrogen and progesterone together expand murine endometrial epithelial progenitor cells.

Stem cells (Dayton, Ohio)

Janzen DM,Cheng D,Schafenacker AM,Paik DY,Goldstein AS,Witte ON,Jaroszewicz A,Pellegrini M,Memarzadeh S

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Apr 01 00:00:00 EDT 2013

Clonally diverse T cell homeostasis is maintained by a common program of cell-cycle control.

Journal of immunology (Baltimore, Md. : 1950)

Hogan T,Shuvaev A,Commenges D,Yates A,Callard R,Thiebaut R,Seddon B

47-0441 was used in Flow cytometry/Cell sorting to analyse the heterogenous proliferative response of T cell clones to lymphopenia using in vivo and mathematical models.

Mon Apr 15 00:00:00 EDT 2013

Increased invasion and tumorigenicity capacity of CD44+/CD24- breast cancer MCF7 cells in vitro and in nude mice.

Cancer cell international

Yan W,Chen Y,Yao Y,Zhang H,Wang T

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Mon Jun 24 00:00:00 EDT 2013

Microvesicles derived from human umbilical cord Wharton's jelly mesenchymal stem cells attenuate bladder tumor cell growth in vitro and in vivo.

PloS one

Wu S,Ju GQ,Du T,Zhu YJ,Liu GH

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue Oct 22 00:00:00 EDT 2013

Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.

The Journal of experimental medicine

Austin WR,Armijo AL,Campbell DO,Singh AS,Hsieh T,Nathanson D,Herschman HR,Phelps ME,Witte ON,Czernin J,Radu CG

47-0441 was used in Flow cytometry/Cell sorting to investigate a functional link between nucleotide deficiency, replication stress, and two enzymes of the nucleoside salvage pathway: deoxycytidine kinase and thymidine kinase.

Mon Nov 19 00:00:00 EST 2012

Nitric oxide inhibits the accumulation of CD4+CD44hiTbet+CD69lo T cells in mycobacterial infection.

European journal of immunology

Pearl JE,Torrado E,Tighe M,Fountain JJ,Solache A,Strutt T,Swain S,Appelberg R,Cooper AM

47-0441 was used in Flow cytometry/Cell sorting to support the hypothesis that effector T cells in mycobacterial granulomata are not a uniform effector population but exist in distinct subsets with differential susceptibility to the regulatory effects of nitric oxide.

Sat Dec 01 00:00:00 EST 2012

Increased protection from vaccinia virus infection in mice genetically prone to lymphoproliferative disorders.

Journal of virology

Seedhom MO,Mathurin KS,Kim SK,Welsh RM

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Jun 01 00:00:00 EDT 2012

Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation.

Stem cells (Dayton, Ohio)

Paik DY,Janzen DM,Schafenacker AM,Velasco VS,Shung MS,Cheng D,Huang J,Witte ON,Memarzadeh S

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Nov 01 00:00:00 EDT 2012

A critical role for Rictor in T lymphopoiesis.

Journal of immunology (Baltimore, Md. : 1950)

Tang F,Wu Q,Ikenoue T,Guan KL,Liu Y,Zheng P

47-0441 was used in Flow cytometry/Cell sorting to investigate the signalling pathway required for T lymphopoiesis, showing a critical role for Rictor.

Wed Aug 15 00:00:00 EDT 2012

The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering.

The Journal of biological chemistry

Yang C,Cao M,Liu H,He Y,Xu J,Du Y,Liu Y,Wang W,Cui L,Hu J,Gao F

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Dec 14 00:00:00 EST 2012

The high and low molecular weight forms of hyaluronan have distinct effects on CD44 clustering.

The Journal of biological chemistry

Yang C,Cao M,Liu H,He Y,Xu J,Du Y,Liu Y,Wang W,Cui L,Hu J,Gao F

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Dec 14 00:00:00 EST 2012

GLI1 confers profound phenotypic changes upon LNCaP prostate cancer cells that include the acquisition of a hormone independent state.

PloS one

Nadendla SK,Hazan A,Ward M,Harper LJ,Moutasim K,Bianchi LS,Naase M,Ghali L,Thomas GJ,Prowse DM,Philpott MP,Neill GW

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Sep 30 00:00:00 EDT 2011

Two host factors regulate persistence of H7-specific T cells injected in tumor-bearing mice.

PloS one

Meunier MC,Baron C,Perreault C

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Fri Feb 13 00:00:00 EST 2009

Effects of Culturing on the Stability of the Putative Murine Adipose Derived Stem Cells Markers.

The open stem cell journal

Maddox JR,Liao X,Li F,Niyibizi C

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2009

Modulation of naive CD4+ T-cell responses to an airway antigen during pulmonary mycobacterial infection.

Infection and immunity

Anis MM,Fulton SA,Reba SM,Harding CV,Boom WH

Published figure using CD44 monoclonal antibody (Product # 47-0441-82) in Flow Cytometry

Tue May 01 00:00:00 EDT 2007

Bioinformatics

Protein Aliases: CD44; CD44 antigen; CD44 molecule; CDw44; cell surface glycoprotein CD44; chondroitin sulfate proteoglycan 8; ECMR-III; ECMRIII; Epican; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; Heparan sulfate proteoglycan; Hermes antigen; homing function and Indian blood group system; HUTCH-I; hyaluronan receptor; Hyaluronate receptor; Ly-24; Lymphocyte antigen 24; PGP I; PGP-1; PGP-I; PGPI; Phagocytic glycoprotein 1; Phagocytic glycoprotein I; sCD 44; sCD44; soluble CD 44; soluble CD44

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Gene Aliases: AU023126; AW121933; AW146109; CD44; CDW44; CSPG8; ECMR-III; HCELL; HERMES; HUTCH-I; IN; LHR; Ly-24; MC56; MDU2; MDU3; MIC4; Pgp-1; Pgp1

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UniProt ID: (Human) Q16064, (Mouse) P15379

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Entrez Gene ID: (Human) 960, (Mouse) 12505

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Function(s)

cytokine receptor activity protein binding collagen binding hyaluronic acid binding hyalurononglucosaminidase activity epidermal growth factor receptor binding protein kinase binding cytokine binding phosphoprotein binding transmembrane signal receptor

Process(es)

cell-matrix adhesion single organismal cell-cell adhesion extracellular matrix disassembly extracellular matrix organization hyaluronan catabolic process positive regulation of peptidyl-serine phosphorylation positive regulation of heterotypic cell-cell adhesion negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of DNA damage response, signal transduction by p53 class mediator cellular response to fibroblast growth factor stimulus positive regulation of peptidyl-tyrosine phosphorylation leukocyte migration cartilage development interferon-gamma-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade monocyte aggregation positive regulation of monocyte aggregation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of cell growth branching involved in ureteric bud morphogenesis wound healing involved in inflammatory response positive regulation of adaptive immune response negative regulation of mature B cell apoptotic process cell adhesion positive regulation of gene expression Wnt signaling pathway cell migration neuron projection development positive regulation of neutrophil apoptotic process macrophage fusion branching involved in prostate gland morphogenesis

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CD44 Monoclonal Antibody (IM7), APC-eFluor™ 780, eBioscience™

CD44 Antibody (47-0441-82) in Flow

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47-0441-82

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