Product References
Embryonic keratin19+ progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla.
Nature communications
Lucas B,White AJ,Klein F,Veiga-Villauriz C,Handel A,Bacon A,Cosway EJ,James KD,Parnell SM,Ohigashi I,Takahama Y,Jenkinson WE,Hollander GA,Lu WY,Anderson G
47-0451-82 was used in Flow cytometry/Cell sorting to identify and define a multipotent mTEC progenitor that emerges during embryogenesis to support mTEC diversity into adult life.
Wed Apr 12 00:00:00 EDT 2023
Macrophage Reprogramming via the Modulation of Unfolded Protein Response with siRNA-Loaded Magnetic Nanoparticles in a TAM-like Experimental Model.
Pharmaceutics
D'Urso A,Oltolina F,Borsotti C,Prat M,Colangelo D,Follenzi A
47-0451-82 was used in Flow cytometry/Cell sorting to provide a novel strategy for the development of new tumor immunotherapies in vivo.
Mon Jun 12 00:00:00 EDT 2023
Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease.
Nature neuroscience
Schäffner E,Bosch-Queralt M,Edgar JM,Lehning M,Strauß J,Fleischer N,Kungl T,Wieghofer P,Berghoff SA,Reinert T,Krueger M,Morawski M,Möbius W,Barrantes-Freer A,Stieler J,Sun T,Saher G,Schwab MH,Wrede C,Frosch M,Prinz M,Reich DS,Flügel A,Stadelmann C,Fledrich R,Nave KA,Stassart RM
47-0451-82 was used in Flow cytometry/Cell sorting to demonstrate that myelin ensheathment itself becomes detrimental for axonal survival and increases the risk of axons degenerating in an autoimmune environment.
Sat Jul 01 00:00:00 EDT 2023
From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia.
Nature communications
Saez-Ayala M,Hoffer L,Abel S,Ben Yaala K,Sicard B,Andrieu GP,Latiri M,Davison EK,Ciufolini MA,Brémond P,Rebuffet E,Roche P,Derviaux C,Voisset E,Montersino C,Castellano R,Collette Y,Asnafi V,Betzi S,Dubreuil P,Combes S,Morelli X
47-0451-82 was used in Flow cytometry/Cell sorting to present the development of a potent inhibitor applying an iterative multidisciplinary approach, which relies on computational design coupled with experimental evaluations.
Mon May 29 00:00:00 EDT 2023
T-cell immunoglobulin- and mucin-domain-containing molecule-4 maintains adipose tissue homeostasis by orchestrating M2 macrophage polarization via nuclear factor kappa B pathway.
Immunology
Ding L,Liang Y,Wang Y,Tong Z,Liu W,Tan S,Zhang J,Wang Y,Wu Z,Liang X,Ma C,Gao L
47-0451-82 was used in Flow cytometry/Cell sorting to reveal that maintainence of adipose tissue homeostasis occurs via Tim-4 by regulating macrophage polarization via NF-κB pathway.
Sun Jan 01 00:00:00 EST 2023
Interventional hydrogel microsphere vaccine as an immune amplifier for activated antitumour immunity after ablation therapy.
Nature communications
Liu X,Zhuang Y,Huang W,Wu Z,Chen Y,Shan Q,Zhang Y,Wu Z,Ding X,Qiu Z,Cui W,Wang Z
47-0451-82 was used in Flow Cytometry to show in an orthotopic pancreatic cancer model in male mice that the hydrogel microsphere vaccine transforms the immunologically cold tumour microenvironment into hot in a safe and efficient manner, thus significantly increasing survival and inhibiting the growth of distant metastases.
Tue Jul 11 00:00:00 EDT 2023
Renal control of life-threatening malarial anemia.
Cell reports
Wu Q,Sacomboio E,Valente de Souza L,Martins R,Kitoko J,Cardoso S,Ademolue TW,Paixão T,Lehtimäki J,Figueiredo A,Norden C,Tharaux PL,Weiss G,Wang F,Ramos S,Soares MP
47-0451-82 was used in Flow Cytometry to identify a transcriptional response that endows renal proximal tubule epithelial cells (RPTECs) with the capacity to store and recycle iron during P. chabaudi chabaudi (Pcc) infection.
Tue Feb 28 00:00:00 EST 2023
Single-cell sequencing reveals homogeneity and heterogeneity of the cytopathological mechanisms in different etiology-induced AKI.
Cell death & disease
Chen Z,Li Y,Yuan Y,Lai K,Ye K,Lin Y,Lan R,Chen H,Xu Y
47-0451-82 was used in Flow Cytometry to provide a potent resource for understanding the pathogenesis of acute kidney injury AKI and early intervention in AKI progression at single-cell resolution.
Thu May 11 00:00:00 EDT 2023
Niche-expressed Galectin-1 is involved in pre-B acute lymphoblastic leukemia relapse through pre-B cell receptor activation.
iScience
Pelletier J,Balzano M,Destin J,Montersino C,Delahaye MC,Marchand T,Bailly AL,Bardin F,Coppin E,Goubard A,Castellano R,de Bruijn MJW,Rip J,Collette Y,Dubreuil P,Tarte K,Broccardo C,Hendriks RW,Schiff C,Vey N,Aurrand-Lions M,Mancini SJC
47-0451-82 was used in Flow cytometry/Cell sorting to show that non-cell autonomous signals transmitted by BM niches represent promising targets to improve B-ALL patient survival.
Fri Apr 21 00:00:00 EDT 2023
Logic-gated antibody pairs that selectively act on cells co-expressing two antigens.
Nature biotechnology
Oostindie SC,Rinaldi DA,Zom GG,Wester MJ,Paulet D,Al-Tamimi K,van der Meijden E,Scheick JR,Wilpshaar T,de Jong B,Hoff-van den Broek M,Grattan RM,Oosterhoff JJ,Vignau J,Verploegen S,Boross P,Beurskens FJ,Lidke DS,Schuurman J,de Jong RN
47-0451-82 was used in Flow cytometry/Cell sorting to show that HexElect® allows selective antibody activity on target cells expressing unique, potentially unexplored combinations of surface antigens.
Sat Oct 01 00:00:00 EDT 2022
Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections.
Cell reports
Brandi P,Conejero L,Cueto FJ,Martínez-Cano S,Dunphy G,Gómez MJ,Relaño C,Saz-Leal P,Enamorado M,Quintas A,Dopazo A,Amores-Iniesta J,Del Fresno C,Nistal-Villán E,Ardavín C,Nieto A,Casanovas M,Subiza JL,Sancho D
47-0451-82 was used in Flow cytometry/Cell sorting to show that intranasal prophylaxis with MV130 modulates the lung immune landscape and provides long-term heterologous protection against viral respiratory infections in mice.
Tue Jan 04 00:00:00 EST 2022
The parasitic worm product ES-62 protects the osteoimmunology axis in a mouse model of obesity-accelerated ageing.
Frontiers in immunology
Harnett MM,Doonan J,Lumb FE,Crowe J,Damink RO,Buitrago G,Duncombe-Moore J,Wilkinson DI,Suckling CJ,Selman C,Harnett W
47-0451-82 was used in Flow cytometry/Cell sorting to report the ability of small drug-like molecule analogues of ES-62 to mimic some of its key actions, particularly in strongly protecting trabecular bone structure, highlighting the translational potential of these studies.
Fri Sep 16 00:00:00 EDT 2022
Lineage tracing clarifies the cellular origin of tissue-resident macrophages in the developing heart.
The Journal of cell biology
Liu K,Jin H,Tang M,Zhang S,Tian X,Zhang M,Han X,Liu X,Tang J,Pu W,Li Y,He L,Yang Z,Lui KO,Zhou B
47-0451-82 was used in Flow cytometry/Cell sorting to generate new genetic tools to trace endocardial cells and reassessed their potential contribution to hematopoietic cells in the developing heart. Fate-mapping analyses revealed that the endocardium contributed minimally to cardiac macrophages and circulating blood cells.
Mon Jun 06 00:00:00 EDT 2022
High-yield enrichment of mouse small intestine intraepithelial lymphocytes by immunomagnetic depletion of EpCAM+ cells.
STAR protocols
Prakhar P,Gonzalez V,Park JH
47-0451-82 was used in Flow Cytometry to describe a magnetic cell separation protocol that employs anti-epithelial cellular adhesion molecule (EpCAM) antibodies to deplete epithelial cells and to enrich for intraepithelial lymphocytes from small intestine tissues.
Fri Mar 18 00:00:00 EDT 2022
NLRP6 Inflammasome Modulates Disease Progression in a Chronic-Plus-Binge Mouse Model of Alcoholic Liver Disease.
Cells
Mainz RE,Albers S,Haque M,Sonntag R,Treichel NS,Clavel T,Latz E,Schneider KM,Trautwein C,Otto T
47-0451-82 was used in Flow cytometry/Cell sorting to evaluate a novel mouse model for ALD characterized by 8-week chronic-plus-binge ethanol administration and to investigate the role of NLRP6 inflammasome for intestinal homeostasis and ALD progression using Nlrp6-/- mice.
Thu Jan 06 00:00:00 EST 2022
Hematopoietic Cells Influence Vascular Development in the Retina.
Cells
Asare-Bediako B,Adu-Agyeiwaah Y,Abad A,Li Calzi S,Floyd JL,Prasad R,DuPont M,Asare-Bediako R,Bustelo XR,Grant MB
47-0451-82 was used in Flow cytometry/Cell sorting to provide further evidence for the underappreciated role of hematopoietic cells in retinal vasculogenesis and the formation of a healthy retina.
Thu Oct 13 00:00:00 EDT 2022
Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence.
iScience
Riding AM,Loudon KW,Guo A,Ferdinand JR,Lok LSC,Richoz N,Stewart A,Castro-Dopico T,Tuong ZK,Fiancette R,Bowyer GS,Fleming A,Gillman ES,Suchanek O,Mahbubani KT,Saeb-Parsy K,Withers D,Dougan G,Clare S,Clatworthy MR
47-0451-82 was used in Flow cytometry/Cell sorting to provide important insights into the orchestration and execution of type 17 immunity in bladder defense.
Fri Jul 15 00:00:00 EDT 2022
Nt5e deficiency does not affect post-stroke inflammation and lesion size in a murine ischemia/reperfusion stroke model.
iScience
Schädlich IS,Schnapauff O,Pöls L,Schrader J,Tolosa E,Rissiek B,Magnus T
47-0451-82 was used in Flow cytometry/Cell sorting to highlight the potential impact of stroke models on study outcome and the need for cross-validation of originally promising immunomodulatory candidates.
Fri Jun 17 00:00:00 EDT 2022
A novel ZsGreen knock-in melanoma cell line reveals the function of CD11b in tumor phagocytosis.
Immunology and cell biology
Zhang L,Feng X,Shen Y,Wang Y,Liu Z,Ma Y,Gu Y,Guo G,Duan L,Lu L,Liang Y,Lawrence T,Huang R
47-0451-82 was used in Flow cytometry/Cell sorting to demonstrate that the ZsGreen-expressing YUMM1.7 melanoma model provides a valuable tool for the study of phagocytosis in vivo.
Sat Oct 01 00:00:00 EDT 2022
Tumor microenvironment remodeling modulates macrophage phenotype in breast cancer lymphangiogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Du Y,Cao M,Liu Y,He Y,Yang C,Zhang G,Fan Y,Gao F
47-0451-82 was used in Flow Cytometry to study the crosstalk between HA in TME and macrophages dependent lymphangiogenesis.
Fri Apr 01 00:00:00 EDT 2022
Candida albicans oscillating UME6 expression during intestinal colonization primes systemic Th17 protective immunity.
Cell reports
Shao TY,Kakade P,Witchley JN,Frazer C,Murray KL,Ene IV,Haslam DB,Hagan T,Noble SM,Bennett RJ,Way SS
47-0451-82 was used in Flow cytometry/Cell sorting to show that dynamic gene expression fluctuations by C. albicans during symbiotic colonization are essential for priming host immunity against disseminated infection.
Tue May 17 00:00:00 EDT 2022
GSDMD-dependent neutrophil extracellular traps promote macrophage-to-myofibroblast transition and renal fibrosis in obstructive nephropathy.
Cell death & disease
Wang Y,Li Y,Chen Z,Yuan Y,Su Q,Ye K,Chen C,Li G,Song Y,Chen H,Xu Y
47-0451-82 was used in Flow cytometry/Cell sorting to investigate the underlying molecular mechanism behind the promotion of renal fibrosis by inflammatory cells.
Mon Aug 08 00:00:00 EDT 2022
IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment.
Immunity
Lin X,Gaudino SJ,Jang KK,Bahadur T,Singh A,Banerjee A,Beaupre M,Chu T,Wong HT,Kim CK,Kempen C,Axelrad J,Huang H,Khalid S,Shah V,Eskiocak O,Parks OB,Berisha A,McAleer JP,Good M,Hoshino M,Blumberg R,Bialkowska AB,Gaffen SL,Kolls JK,Yang VW,Beyaz S,Cadwell K,Kumar P
47-0451-82 was used in Flow cytometry/Cell sorting to suggest that the cross talk between immune cells and stem cells regulates secretory cell lineage commitment and the integrity of the mucosa.
Tue Feb 08 00:00:00 EST 2022
Age-Associated Changes to Lymph Node Fibroblastic Reticular Cells.
Frontiers in aging
Kwok T,Medovich SC,Silva-Junior IA,Brown EM,Haug JC,Barrios MR,Morris KA,Lancaster JN
47-0451-82 was used in Flow cytometry/Cell sorting to address the controversy as to whether aging impacts the composition lymph node stroma and supports a model in which impaired differentiation of lymph node fibroblasts and increased fibrosis inhibits the interactions necessary for naive T cell homeostasis.
Sat Jul 16 00:00:00 EDT 2022
Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity.
Cell
Leonardi I,Gao IH,Lin WY,Allen M,Li XV,Fiers WD,De Celie MB,Putzel GG,Yantiss RK,Johncilla M,Colak D,Iliev ID
47-0451-82 was used in Flow cytometry/Cell sorting to characterize the mycobiota biogeography along the gastrointestinal tract and identified a subset of fungi associated with the intestinal mucosa of mice and humans.
Thu Mar 03 00:00:00 EST 2022
Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota.
Cell
Lima-Junior DS,Krishnamurthy SR,Bouladoux N,Collins N,Han SJ,Chen EY,Constantinides MG,Link VM,Lim AI,Enamorado M,Cataisson C,Gil L,Rao I,Farley TK,Koroleva G,Attig J,Yuspa SH,Fischbach MA,Kassiotis G,Belkaid Y
47-0451-82 was used in Flow Cytometry to determine response to chemical signalling caused by endogenous retrovirus in skin microbiota.
Thu Jul 08 00:00:00 EDT 2021
Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation.
Immunity
Medina CB,Chiu YH,Stremska ME,Lucas CD,Poon I,Tung KS,Elliott MR,Desai B,Lorenz UM,Bayliss DA,Ravichandran KS
47-0451-82 was used in Flow cytometry/Cell sorting to uncover an immunoregulatory role for the nucleotide release channel, Panx1, in T cell crosstalk during airway disease.
Tue Aug 10 00:00:00 EDT 2021
Murine model of colonization with fungal pathogen Candida auris to explore skin tropism, host risk factors and therapeutic strategies.
Cell host & microbe
Huang X,Hurabielle C,Drummond RA,Bouladoux N,Desai JV,Sim CK,Belkaid Y,Lionakis MS,Segre JA
47-0451-82 was used in Flow Cytometry to develop a murine skin topical exposure model for C. auris to dissect risk factors for colonization and to test interventions that might protect patients.
Wed Feb 10 00:00:00 EST 2021
Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling.
The EMBO journal
Wieghofer P,Hagemeyer N,Sankowski R,Schlecht A,Staszewski O,Amann L,Gruber M,Koch J,Hausmann A,Zhang P,Boneva S,Masuda T,Hilgendorf I,Goldmann T,Böttcher C,Priller J,Rossi FM,Lange C,Prinz M
47-0451-82 was used in Flow Cytometry to examine myeloid subsets in distinct parts of the eye during homeostasis.
Mon Mar 15 00:00:00 EDT 2021
Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects.
Basic research in cardiology
Frenis K,Helmstädter J,Ruan Y,Schramm E,Kalinovic S,Kröller-Schön S,Bayo Jimenez MT,Hahad O,Oelze M,Jiang S,Wenzel P,Sommer CJ,Frauenknecht KBM,Waisman A,Gericke A,Daiber A,Münzel T,Steven S
47-0451 was used in Flow cytometry/Cell sorting to determine the role of myeloid cells in the vascular vs. cerebral consequences of exposure to aircraft noise.
Fri Apr 30 00:00:00 EDT 2021
SORLA is required for insulin-induced expansion of the adipocyte precursor pool in visceral fat.
The Journal of cell biology
Schmidt V,Horváth C,Dong H,Blüher M,Qvist P,Wolfrum C,Willnow TE
47-0451-82 was used in Flow Cytometry to identify the insulin-sensitizing receptor SORLA as a molecular factor explaining the distinct proliferative capacity of visceral white adipose tissue.
Mon Dec 06 00:00:00 EST 2021
IGF1R controls mechanosignaling in myofibroblasts required for pulmonary alveologenesis.
JCI insight
He H,Snowball J,Sun F,Na CL,Whitsett JA
47-0451-82 was used in Flow cytometry/Cell sorting to demonstrate that IGF1 receptor gene (Igf1r) expression by a subset of pulmonary fibroblasts is required for normal alveologenesis in mice.
Mon Mar 22 00:00:00 EDT 2021
Generation of neighbor-labeling cells to study intercellular interactions in vivo.
Nature protocols
Ombrato L,Nolan E,Passaro D,Kurelac I,Bridgeman VL,Waclawiczek A,Duarte D,Lo Celso C,Bonnet D,Malanchi I
47-0451-82 was used in Immunohistochemistry to study cell-cell interactions in cancer and metastasis with Cherry-niche.
Mon Feb 01 00:00:00 EST 2021
Colorectal cancer cells utilize autophagy to maintain mitochondrial metabolism for cell proliferation under nutrient stress.
JCI insight
Devenport SN,Singhal R,Radyk MD,Taranto JG,Kerk SA,Chen B,Goyert JW,Jain C,Das NK,Oravecz-Wilson K,Zhang L,Greenson JK,Chen YE,Soleimanpour SA,Reddy P,Lyssiotis CA,Shah YM
47-0451-82 was used in Flow Cytometry to demonstrate a cell-autonomous dependency of autophagy for cell growth in colorectal cancer.
Thu Jun 17 00:00:00 EDT 2021
Generation and utilization of a HEK-293T murine GM-CSF expressing cell line.
PloS one
Robinson EK,Covarrubias S,Zhou S,Carpenter S
47-0451-82 was used in Flow Cytometry to show that supernatant from our GM-CSF HEK293T cell line supports the differentiation of mouse BMDCs or alveolar macrophage culturing, providing an economical alternative to purified GM-CSF.
Wed Sep 15 00:00:00 EDT 2021
Protocols for isolation and characterization of mouse placental hemogenic endothelial cells.
STAR protocols
Liang G,Huang B,Wang F,Liu F
47-0451-82 was used in Immunocytochemistry to describe a protocol for isolation and characterization of the hemogenic endothelial (HE) cells from mouse placenta.
Fri Dec 17 00:00:00 EST 2021
Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells.
Nature metabolism
Schwartz AJ,Goyert JW,Solanki S,Kerk SA,Chen B,Castillo C,Hsu PP,Do BT,Singhal R,Dame MK,Lee HJ,Spence JR,Lakhal-Littleton S,Vander Heiden MG,Lyssiotis CA,Xue X,Shah YM
47-0451-82 was used in Flow Cytometry to demonstrate that hepcidin is activated ectopically in colorectal cancer.
Thu Jul 01 00:00:00 EDT 2021
Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression.
Nature communications
Johann K,Bohn T,Shahneh F,Luther N,Birke A,Jaurich H,Helm M,Klein M,Raker VK,Bopp T,Barz M,Becker C
47-0451-82 was used in Flow cytometry/Cell sorting to show that the release of non-toxic concentrations of an adenylate cyclase (AC) inhibitor from poly(sarcosine)-block-poly(L-glutamic acid γ-benzyl ester) (polypept(o)id) copolymer micelles restores antitumor immunity.
Wed Oct 13 00:00:00 EDT 2021
Testosterone metabolites differentially regulate obesogenesis and fat distribution.
Molecular metabolism
Sebo ZL,Rodeheffer MS
47-0451-80 was used in Flow Cytometry to clarify the role of testosterone and its downstream metabolites in the regulation of fat distribution.
Mon Feb 01 00:00:00 EST 2021
Combined Prebiotic and Microbial Intervention Improves Oral Cholera Vaccination Responses in a Mouse Model of Childhood Undernutrition.
Cell host & microbe
Di Luccia B,Ahern PP,Griffin NW,Cheng J,Guruge JL,Byrne AE,Rodionov DA,Leyn SA,Osterman AL,Ahmed T,Colonna M,Barratt MJ,Delahaye NF,Gordon JI
47-0451-82 was used in Flow Cytometry to provide preclinical proof-of-concept that diet and microbiota influence mucosal immune responses to CT vaccination and identify a candidate synbiotic formulation.
Wed Jun 10 00:00:00 EDT 2020
Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair.
Cell stem cell
Shook BA,Wasko RR,Mano O,Rutenberg-Schoenberg M,Rudolph MC,Zirak B,Rivera-Gonzalez GC,López-Giráldez F,Zarini S,Rezza A,Clark DA,Rendl M,Rosenblum MD,Gerstein MB,Horsley V
47-0451-82 was used in Flow Cytometry to identify an essential role for adipocyte lipolysis in regulating inflammation and repair after injury in skin.
Thu Jun 04 00:00:00 EDT 2020
Immunosuppression by Mutated Calreticulin Released from Malignant Cells.
Molecular cell
Liu P,Zhao L,Loos F,Marty C,Xie W,Martins I,Lachkar S,Qu B,Waeckel-Énée E,Plo I,Vainchenker W,Perez F,Rodriguez D,López-Otin C,van Endert P,Zitvogel L,Kepp O,Kroemer G
47-0451-82 was used in Flow Cytometry to demonstrate the paracrine immunosuppressive effects for exon-9-mutated C-terminally modified calreticulin.
Thu Feb 20 00:00:00 EST 2020
MALT1 targeting suppresses CARD14-induced psoriatic dermatitis in mice.
EMBO reports
Van Nuffel E,Staal J,Baudelet G,Haegman M,Driege Y,Hochepied T,Afonina IS,Beyaert R
47-0451-82 was used in Flow Cytometry to investigate if inducible keratinocyte-specific expression of CARD14E138A in mice rapidly induces epidermal thickening and inflammation as well as increased expression of several genes associated with psoriasis in humans.
Fri Jul 03 00:00:00 EDT 2020
The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet-accelerated mouse model of ageing.
PLoS pathogens
Crowe J,Lumb FE,Doonan J,Broussard M,Tarafdar A,Pineda MA,Landabaso C,Mulvey L,Hoskisson PA,Babayan SA,Selman C,Harnett W,Harnett MM
47-0451-82 was used in Flow Cytometry to investigate the potential of ES-62, an anti-inflammatory secreted product of the filarial nematode Acanthocheilonema viteae, to improve healthspan (the period of life before diseases of ageing appear) by targeting the chronic inflammation that drives metabolic dysregulation underpinning ageing-induced ill-health.
Sun Mar 01 00:00:00 EST 2020
NLRX1 is a key regulator of immune signaling during invasive pulmonary aspergillosis.
PLoS pathogens
Kastelberg B,Tubau-Juni N,Ayubi T,Leung A,Leber A,Hontecillas R,Bassaganya-Riera J,Kale SD
47-0451 was used in Flow cytometry/Cell sorting to point strongly towards the cell-specific and contextual function of Nlrx1 during invasive pulmonary aspergillosis and may lead to novel therapeutics to reduce Th2 responses by CD103+ DCs or heightened recruitment of neutrophils.
Tue Sep 01 00:00:00 EDT 2020
Chemosensitization of prostate cancer stem cells in mice by angiogenin and plexin-B2 inhibitors.
Communications biology
Li S,Goncalves KA,Lyu B,Yuan L,Hu GF
47-0451-82 was used in Flow Cytometry to conclude that monoclonal antibodies of angiogenin and plexin-B2 decrease the stemness of prostate CSCs and sensitize them to chemotherapeutic agents in vitro and in vivo.
Wed Jan 15 00:00:00 EST 2020
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.
Nature communications
Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G
47-0451 was used in Flow cytometry/Cell sorting to study the mechanism that controls the development of αβ T cell lineages in the thymus.
Mon May 04 00:00:00 EDT 2020
Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs.
Cell reports
Gallizioli M,Miró-Mur F,Otxoa-de-Amezaga A,Cugota R,Salas-Perdomo A,Justicia C,Brait VH,Ruiz-Jaén F,Arbaizar-Rovirosa M,Pedragosa J,Bonfill-Teixidor E,Gelderblom M,Magnus T,Cano E,Del Fresno C,Sancho D,Planas AM
47-0451 was used in Flow cytometry/Cell sorting to reveal aspects of the dynamics and functions of brain DCs in the regulation of inflammation and immunity.
Tue Oct 20 00:00:00 EDT 2020
Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia.
Cell reports
Xu G,van Bruggen R,Gualtieri CO,Moradin N,Fois A,Vallerand D,De Sa Tavares Russo M,Bassenden A,Lu W,Tam M,Lesage S,Girouard H,Avizonis DZ,Deblois G,Prchal JT,Stevenson M,Berghuis A,Muir T,Rabinowitz J,Vidal SM,Fodil N,Gros P
47-0451 was used in Flow cytometry/Cell sorting to highlight the importance of BPGM as a regulator of hemoglobin/oxyhemoglobin in malaria pathogenesis and suggest a new potential malaria therapeutic target.
Tue Sep 22 00:00:00 EDT 2020
Effect of Combining Low Temperature Plasma, Negative Pressure Wound Therapy, and Bone Marrow Mesenchymal Stem Cells on an Acute Skin Wound Healing Mouse Model.
International journal of molecular sciences
Cui HS,Joo SY,Cho YS,Park JH,Kim JB,Seo CH
47-0451 was used in Flow cytometry/Cell sorting to show combination therapy with LPT, NPWT, and MSC may be a promising strategy for treatment of acute wounds.
Sat May 23 00:00:00 EDT 2020
Osterix-Cre marks distinct subsets of CD45- and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics.
eLife
Ricci B,Tycksen E,Celik H,Belle JI,Fontana F,Civitelli R,Faccio R
47-0451 was used in Flow cytometry/Cell sorting to find Osx transcript and Osx protein expression early during hematopoiesis, in subsets of hematopoietic stem cells and multipotent progenitor populations.
Wed Aug 05 00:00:00 EDT 2020
Inflammation-Induced Lactate Leads to Rapid Loss of Hepatic Tissue-Resident NK Cells.
Cell reports
Dodard G,Tata A,Erick TK,Jaime D,Miah SMS,Quatrini L,Escalière B,Ugolini S,Vivier E,Brossay L
47-0451 was used in Flow cytometry/Cell sorting to characterize the kinetics and immune response of each of the hepatic NK cell populations to viral challenge and other stimuli.
Tue Jul 07 00:00:00 EDT 2020
MyD88-dependent signaling in non-parenchymal cells promotes liver carcinogenesis.
Carcinogenesis
Mohs A,Kuttkat N,Otto T,Youssef SA,De Bruin A,Trautwein C
47-0451-82 was used in Flow cytometry/Cell sorting to suggest that signaling of Toll-like receptors through MyD88 in non-parenchymal liver cells is required for carcinogenesis during chronic liver injury.
Wed Apr 22 00:00:00 EDT 2020
The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.
Cell
Collins N,Han SJ,Enamorado M,Link VM,Huang B,Moseman EA,Kishton RJ,Shannon JP,Dixit D,Schwab SR,Hickman HD,Restifo NP,McGavern DB,Schwartzberg PL,Belkaid Y
47-0451-82 was used in Flow Cytometry to show that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction (DR) but dramatically accumulated within the bone marrow (BM), where they adopted a state associated with energy conservation.
Thu Aug 22 00:00:00 EDT 2019
The cis-Regulatory Atlas of the Mouse Immune System.
Cell
Yoshida H,Lareau CA,Ramirez RN,Rose SA,Maier B,Wroblewska A,Desland F,Chudnovskiy A,Mortha A,Dominguez C,Tellier J,Kim E,Dwyer D,Shinton S,Nabekura T,Qi Y,Yu B,Robinette M,Kim KW,Wagers A,Rhoads A,Nutt SL,Brown BD,Mostafavi S,Buenrostro JD,Benoist C
47-0451-82 was used in Flow Cytometry to generate matched epigenome and transcriptome measurements in 86 primary cell types that span the mouse immune system and its differentiation cascade.
Thu Feb 07 00:00:00 EST 2019
Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells.
Nature cell biology
Nakahara F,Borger DK,Wei Q,Pinho S,Maryanovich M,Zahalka AH,Suzuki M,Cruz CD,Wang Z,Xu C,Boulais PE,Ma'ayan A,Greally JM,Frenette PS
47-0451-82 was used in Flow Cytometry to provide insight into the transcriptional regulation of the niche with implications for stem cell-based therapies.
Wed May 01 00:00:00 EDT 2019
Natural killer cells limit the clearance of senescent lung adenocarcinoma cells.
Oncogenesis
Stokes KL,Cortez-Retamozo V,Acosta J,Lauderback B,Robles-Oteiza C,Cicchini M,Pittet MJ,Feldser DM
Mon Apr 01 00:00:00 EDT 2019
HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy.
Oncoimmunology
Triulzi T,Forte L,Regondi V,Di Modica M,Ghirelli C,Carcangiu ML,Sfondrini L,Balsari A,Tagliabue E
47-0451 was used in Flow cytometry/Cell sorting to investigate the relationship between HER2 activity and the pro-trastuzumab tumour immune milieu.
Tue Jan 12 00:00:00 EST 2021
Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses.
Nature communications
Kurelac I,Iommarini L,Vatrinet R,Amato LB,De Luise M,Leone G,Girolimetti G,Umesh Ganesh N,Bridgeman VL,Ombrato L,Columbaro M,Ragazzi M,Gibellini L,Sollazzo M,Feichtinger RG,Vidali S,Baldassarre M,Foriel S,Vidone M,Cossarizza A,Grifoni D,Kofler B,Malanchi I,Porcelli AM,Gasparre G
47-0451-82 was used in Flow Cytometry to demonstrate that respiratory complex I-deficient tumours survive and carry out angiogenesis, despite their inability to stabilise Hypoxia Inducible Factor-1 alpha.
Fri Feb 22 00:00:00 EST 2019
Intestinal non-canonical NFκB signaling shapes the local and systemic immune response.
Nature communications
Ramakrishnan SK,Zhang H,Ma X,Jung I,Schwartz AJ,Triner D,Devenport SN,Das NK,Xue X,Zeng MY,Hu Y,Mortensen RM,Greenson JK,Cascalho M,Wobus CE,Colacino JA,Nunez G,Rui L,Shah YM
47-0451 was used in Flow cytometry/Cell sorting to determine the role of Microfold cells in systemic inflammatory responses.
Fri Feb 08 00:00:00 EST 2019
A Humanized Bone Niche Model Reveals Bone Tissue Preservation Upon Targeting Mitochondrial Complex I in Pseudo-Orthotopic Osteosarcoma.
Journal of clinical medicine
Kurelac I,Abarrategi A,Ragazzi M,Iommarini L,Umesh Ganesh N,Snoeks T,Bonnet D,Porcelli AM,Malanchi I,Gasparre G
47-0451 was used in Flow cytometry/Cell sorting to characterize the tumour microenvironment of mitochondrial complex I deficient tumors in a model that represents osteosarcoma development.
Wed Dec 11 00:00:00 EST 2019
Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-κB/TNF-α pathway.
Molecular metabolism
Yang H,Xie T,Li D,Du X,Wang T,Li C,Song X,Xu L,Yi F,Liang X,Gao L,Yang X,Ma C
47-0451 was used in Flow cytometry/Cell sorting to study T cell immunoglobulin domain and mucin domain-3 as a regulator in renal inflammation.
Wed May 01 00:00:00 EDT 2019
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.
Nature medicine
Maryanovich M,Zahalka AH,Pierce H,Pinho S,Nakahara F,Asada N,Wei Q,Wang X,Ciero P,Xu J,Leftin A,Frenette PS
47-0451 was used in Flow cytometry/Cell sorting to determine whether haematopoietic stem cell ageing depends on bone marrow innervation by the sympathetic nervous system.
Fri Jun 01 00:00:00 EDT 2018
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
Thu Jun 28 00:00:00 EDT 2018
Chanzyme TRPM7 Mediates the Ca2+ Influx Essential for Lipopolysaccharide-Induced Toll-Like Receptor 4 Endocytosis and Macrophage Activation.
Immunity
Schappe MS,Szteyn K,Stremska ME,Mendu SK,Downs TK,Seegren PV,Mahoney MA,Dixit S,Krupa JK,Stipes EJ,Rogers JS,Adamson SE,Leitinger N,Desai BN
47-0451-82 was used in Flow cytometry/Cell sorting to study the role of transient receptor potential melastatin-like 7 in mediating the cytosolic Ca2+ elevations essential for lipopolysaccharide-induced macrophage activation.
Tue Jan 16 00:00:00 EST 2018
Quiescent Tissue Stem Cells Evade Immune Surveillance.
Immunity
Agudo J,Park ES,Rose SA,Alibo E,Sweeney R,Dhainaut M,Kobayashi KS,Sachidanandam R,Baccarini A,Merad M,Brown BD
47-0451 was used in Flow cytometry/Cell sorting to identify a link between stem cell quiescence, antigen presentation, and immune evasion.
Tue Feb 20 00:00:00 EST 2018
Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency.
Nature immunology
Kong XF,Martinez-Barricarte R,Kennedy J,Mele F,Lazarov T,Deenick EK,Ma CS,Breton G,Lucero KB,Langlais D,Bousfiha A,Aytekin C,Markle J,Trouillet C,Jabot-Hanin F,Arlehamn CSL,Rao G,Picard C,Lasseau T,Latorre D,Hambleton S,Deswarte C,Itan Y,Abarca K,Moraes-Vasconcelos D,Ailal F,Ikinciogullari A,Dogu F,Benhsaien I,Sette A,Abel L,Boisson-Dupuis S,Schröder B,Nussenzweig MC,Liu K,Geissmann F,Tangye SG,Gros P,Sallusto F,Bustamante J,Casanova JL
47-0451-82 was used in Flow Cytometry to suggest that inherited SPPL2a deficiency in humans underlies mycobacterial disease by decreasing the numbers of cDC2s and impairing IFN-γ production by mycobacterium-specific memory TH1* cells.
Sat Sep 01 00:00:00 EDT 2018
Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression.
Cancer research
Kwak JW,Laskowski J,Li HY,McSharry MV,Sippel TR,Bullock BL,Johnson AM,Poczobutt JM,Neuwelt AJ,Malkoski SP,Weiser-Evans MC,Lambris JD,Clambey ET,Thurman JM,Nemenoff RA
47-0451 was used in Flow cytometry/Cell sorting to study the mechanism relating complement activation to tumour progression in multiple immunocompetent orthotopic models of lung cancer.
Mon Jan 01 00:00:00 EST 2018
Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis.
Journal of cell science
Pala F,Di Girolamo D,Mella S,Yennek S,Chatre L,Ricchetti M,Tajbakhsh S
47-0451 was used in Flow cytometry/Cell sorting to characterise the metabolic pathways that mediate the commitment and differentiation of mouse skeletal muscle stem cells, and how their modulation can influence the cell state.
Fri Jul 27 00:00:00 EDT 2018
A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.
eLife
Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY
47-0451 was used in Flow cytometry/Cell sorting to study the activation of Bcl11b, which controls T-cell fate commitment.
Tue Nov 20 00:00:00 EST 2018
A mesodermal fate map for adipose tissue.
Development (Cambridge, England)
Sebo ZL,Jeffery E,Holtrup B,Rodeheffer MS
47-0451-82 was used in Flow cytometry/Cell sorting to present evidence that 50% of interscapular brown adipocytes are derived from progenitors of the central dermomyotome.
Fri Aug 17 00:00:00 EDT 2018
Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer.
Nature communications
Cazet AS,Hui MN,Elsworth BL,Wu SZ,Roden D,Chan CL,Skhinas JN,Collot R,Yang J,Harvey K,Johan MZ,Cooper C,Nair R,Herrmann D,McFarland A,Deng N,Ruiz-Borrego M,Rojo F,Trigo JM,Bezares S,Caballero R,Lim E,Timpson P,O'Toole S,Watkins DN,Cox TR,Samuel MS,Martín M,Swarbrick A
47-0451 was used in Flow cytometry/Cell sorting to assess the role of tumor-stromal interactions, and how they can be targeted to overcome chemoresistance in triple negative breast cancer.
Tue Jul 24 00:00:00 EDT 2018
Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge.
Nature communications
Yi S,Zhai J,Niu R,Zhu G,Wang M,Liu J,Huang H,Wang Y,Jing X,Kang L,Song W,Shi Y,Tang H
47-0451 was used in Flow cytometry/Cell sorting to suggest that different lung antigen-presenting cells modulate lung cDC1-mediated eosinophil recruitment dynamically.
Mon Sep 24 00:00:00 EDT 2018
Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium.
Cell research
Zhang H,Huang X,Liu K,Tang J,He L,Pu W,Liu Q,Li Y,Tian X,Wang Y,Zhang L,Yu Y,Wang H,Hu R,Wang F,Chen T,Wang QD,Qiao Z,Zhang L,Lui KO,Zhou B
47-0451 was used in Immunohistochemistry to examine the origin of the excessive fibroblasts found within endocardial fibroelastosis-like tissues.
Fri Sep 01 00:00:00 EDT 2017
Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination.
Cancer research
Jiang H,Rivera-Molina Y,Gomez-Manzano C,Clise-Dwyer K,Bover L,Vence LM,Yuan Y,Lang FF,Toniatti C,Hossain MB,Fueyo J
47-0451 was used in Flow cytometry/Cell sorting to demonstrate that combining an oncolytic virus with tumor-targeting immune checkpoint modulators elicits potent in situ autologous cancer vaccination, resulting in an efficacious, tumor-specific, and long-lasting therapeutic effect.
Sat Jul 15 00:00:00 EDT 2017
Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa.
Frontiers in immunology
Blank T,Goldmann T,Koch M,Amann L,Schön C,Bonin M,Pang S,Prinz M,Burnet M,Wagner JE,Biel M,Michalakis S
47-0451 was used in Flow cytometry/Cell sorting to study microglia activation in the development of retinitis pigmentosa.
Wed Nov 20 00:00:00 EST 2019
FHL2 Regulates Natural Killer Cell Development and Activation during Streptococcus pneumoniae Infection.
Frontiers in immunology
Baranek T,Morello E,Valayer A,Aimar RF,Bréa D,Henry C,Besnard AG,Dalloneau E,Guillon A,Dequin PF,Narni-Mancinelli E,Vivier E,Laurent F,Wei Y,Paget C,Si-Tahar M
47-0451 was used in Flow cytometry/Cell sorting to determine the expression and role of FHL2 in natural killer cell biology.
Wed Nov 20 00:00:00 EST 2019
Puberty is an important developmental period for the establishment of adipose tissue mass and metabolic homeostasis.
Adipocyte
Holtrup B,Church CD,Berry R,Colman L,Jeffery E,Bober J,Rodeheffer MS
47-0451 was used in Flow cytometry/Cell sorting to study the effects of exposure to obesogenic stimuli during critical developmental periods on adipose tissue function.
Mon Jul 03 00:00:00 EDT 2017
Batf3-dependent CD8α+ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.
EBioMedicine
Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H
47-0451 was used in Immunofluorescence to show that Batf3-/-Apoe-/- mice, lacking CD8α+ DCs, exhibited a significant reduction in atherogenesis and T help 1 (Th1) cells compared with Apoe-/- controls.
Sat Apr 01 00:00:00 EDT 2017
Injury-Induced Senescence Enables In Vivo Reprogramming in Skeletal Muscle.
Cell stem cell
Chiche A,Le Roux I,von Joest M,Sakai H,Aguín SB,Cazin C,Salam R,Fiette L,Alegria O,Flamant P,Tajbakhsh S,Li H
47-0451 was used in Flow cytometry/Cell sorting to study the effects of acute and chronic injury on transcription-factor-mediated reprogramming in skeletal muscle.
Thu Mar 02 00:00:00 EST 2017
Ankyrin-1 Gene Exhibits Allelic Heterogeneity in Conferring Protection Against Malaria.
G3 (Bethesda, Md.)
Huang HM,Bauer DC,Lelliott PM,Dixon MWA,Tilley L,McMorran BJ,Foote SJ,Burgio G
47-0451 was used in Flow cytometry/Cell sorting to describe the gene encoding erythrocytic ankyrin-1, and outline the resultant exhibition of allelic-dependent heterogeneous phenotypes during murine malarial infection.
Thu Sep 07 00:00:00 EDT 2017
Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.
Cell
Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M
47-0451-82 was used in Mass cytometry to demonstrate a novel mutualistic host-protozoan interaction that increases mucosal host defenses at the cost of an increased risk of inflammatory disease.
Thu Oct 06 00:00:00 EDT 2016
Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.
Cell
Wang A,Huen SC,Luan HH,Yu S,Zhang C,Gallezot JD,Booth CJ,Medzhitov R
47-0451 was used in an ELISA assay to analyse the effects of anorxia in mouse models wih viral and bacterial infections.
Thu Sep 08 00:00:00 EDT 2016
Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis.
Cell stem cell
Rivera-Gonzalez GC,Shook BA,Andrae J,Holtrup B,Bollag K,Betsholtz C,Rodeheffer MS,Horsley V
47-0451 was used in Flow cytometry/Cell sorting to uncover PDGFA as a regulator of adipocyte stem cell self-renewal and proliferation.
Thu Dec 01 00:00:00 EST 2016
Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes.
The Journal of clinical investigation
Inoue T,Abe C,Sung SS,Moscalu S,Jankowski J,Huang L,Ye H,Rosin DL,Guyenet PG,Okusa MD
47-0451 was used in Flow cytometry/Cell sorting to demonstrate that vagus nerve stimulation-mediated attenuation of attenuated acute kidney injury and systemic inflammation depends on α7nAChR-positive splenocytes.
Mon May 02 00:00:00 EDT 2016
IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation.
The Journal of experimental medicine
Lin CC,Bradstreet TR,Schwarzkopf EA,Jarjour NN,Chou C,Archambault AS,Sim J,Zinselmeyer BH,Carrero JA,Wu GF,Taneja R,Artyomov MN,Russell JH,Edelson BT
47-0451 was used in Flow cytometry/Cell sorting to demonstrate that IL-1β induces Bhlhe40 expression in polarized Th17 cells, and Bhlhe40-expressing cells exhibited an encephalitogenic transcriptional signature.
Mon Feb 08 00:00:00 EST 2016
Regionally Restricted Hox Function in Adult Bone Marrow Multipotent Mesenchymal Stem/Stromal Cells.
Developmental cell
Rux DR,Song JY,Swinehart IT,Pineault KM,Schlientz AJ,Trulik KG,Goldstein SA,Kozloff KM,Lucas D,Wellik DM
47-0451 was used in Flow cytometry/Cell sorting to demonstrate Hox11 expression exclusively in multipotent mesenchymal stromal cells in the bone marrow of the adult zeugopod.
Mon Dec 19 00:00:00 EST 2016
Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+ T-cell axis.
Proceedings of the National Academy of Sciences of the United States of America
Brackett CM,Kojouharov B,Veith J,Greene KF,Burdelya LG,Gollnick SO,Abrams SI,Gudkov AV
47-0451 was used in Flow cytometry/Cell sorting to define systemically administered TLR5 agonists as organ-specific immunoadjuvants, enabling efficient antitumor vaccination.
Tue Feb 16 00:00:00 EST 2016
Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1.
Arteriosclerosis, thrombosis, and vascular biology
Herbin O,Regelmann AG,Ramkhelawon B,Weinstein EG,Moore KJ,Alexandropoulos K
47-0451 was used in Flow cytometry/Cell sorting to analyse the role of Chat-H in atherosclerosis development, showing that monocyte adhesion and plaque recruitment is regulated by Chat-H/SHEP1.
Thu Sep 01 00:00:00 EDT 2016
Adipose tissue adaptive response to trans-10,cis-12-conjugated linoleic acid engages alternatively activated M2 macrophages.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Pini M,Touch S,Poirier H,Dalmas E,Niot I,Rouault C,Druart C,Delzenne N,Clément K,André S,Guerre-Millo M
47-0451 was used in Flow cytometry/Cell sorting to reveal a striking resilience of white adipose tissue after a short-term metabolic injury induced by t10,c12-CLA, which relies on alternatively activated M2 macrophage engagement.
Fri Jan 01 00:00:00 EST 2016
Cysteamine broadly improves the anti-plasmodial activity of artemisinins against murine blood stage and cerebral malaria.
Malaria journal
Moradin N,Torre S,Gauthier S,Tam M,Hawari J,Vandercruyssen K,De Spiegeleer B,Fortin A,Stevenson MM,Gros P
47-0451 was used in Flow cytometry/Cell sorting to evaluate the effect of artemisinins and cysteamine combination therapy on malarial phenotypes.
Fri May 06 00:00:00 EDT 2016
Effect of a Ropy Exopolysaccharide-Producing Bifidobacterium animalis subsp. lactis Strain Orally Administered on DSS-Induced Colitis Mice Model.
Frontiers in microbiology
Hidalgo-Cantabrana C,Algieri F,Rodriguez-Nogales A,Vezza T,Martínez-Camblor P,Margolles A,Ruas-Madiedo P,Gálvez J
47-0451 was used in Flow cytometry/Cell sorting to indicate that strains of B. animalis subsp. lactis producing EPS that confer a mucoid-ropy phenotype could represent promising candidates to perform further studies targeting intestinal inflammatory processes.
Mon Jul 04 00:00:00 EDT 2016
CpG-oligodeoxynucleotides exert remarkable antitumor activity against diffuse malignant peritoneal mesothelioma orthotopic xenografts.
Journal of translational medicine
De Cesare M,Sfondrini L,Pennati M,De Marco C,Motta V,Tagliabue E,Deraco M,Balsari A,Zaffaroni N
47-0451 was used in Flow cytometry/Cell sorting to indicate that locally administered CpG-ODN1826 is able to markedly affect the growth of both early- and late-stage DMPM orthotopic xenografts in the absence of severe side effects.
Mon Jan 25 00:00:00 EST 2016
A novel ENU-induced ankyrin-1 mutation impairs parasite invasion and increases erythrocyte clearance during malaria infection in mice.
Scientific reports
Huang HM,Bauer DC,Lelliott PM,Greth A,McMorran BJ,Foote SJ,Burgio G
47-0451 was used in Flow cytometry/Cell sorting to highlight the complex roles that ankyrin plays in mediating malarial resistance.
Wed Nov 16 00:00:00 EST 2016
KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.
Nature medicine
Shankman LS,Gomez D,Cherepanova OA,Salmon M,Alencar GF,Haskins RM,Swiatlowska P,Newman AA,Greene ES,Straub AC,Isakson B,Randolph GJ,Owens GK
47-0451 was used in Flow cytometry/Cell sorting to show how KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.
Mon Jun 01 00:00:00 EDT 2015
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity.
Nature cell biology
Jeffery E,Church CD,Holtrup B,Colman L,Rodeheffer MS
47-0451 was used in Flow cytometry/Cell sorting to study how adipocyte precursor cells are activated depot-specifically at the onset of obesity.
Wed Apr 01 00:00:00 EDT 2015
A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury.
The Journal of experimental medicine
Dal-Secco D,Wang J,Zeng Z,Kolaczkowska E,Wong CH,Petri B,Ransohoff RM,Charo IF,Jenne CN,Kubes P
47-0451 was used in Flow cytometry/Cell sorting to show that phenotypic conversion of monocytes during hepatic injury is essential for optimal repair.
Mon Apr 06 00:00:00 EDT 2015
Osteoprotegerin-Mediated Homeostasis of Rank+ Thymic Epithelial Cells Does Not Limit Foxp3+ Regulatory T Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
McCarthy NI,Cowan JE,Nakamura K,Bacon A,Baik S,White AJ,Parnell SM,Jenkinson EJ,Jenkinson WE,Anderson G
47-0451 was used in Flow cytometry/Cell sorting to elucidate the conditions controlling medullary thymic epithelial cell (mTEC) homeostasis and the production of mTEC-dependent Foxp3(+) Tregs.
Tue Sep 15 00:00:00 EDT 2015
Erythrocytic Iron Deficiency Enhances Susceptibility to Plasmodium chabaudi Infection in Mice Carrying a Missense Mutation in Transferrin Receptor 1.
Infection and immunity
Lelliott PM,McMorran BJ,Foote SJ,Burgio G
47-0451 was used in Flow cytometry/Cell sorting to indicate that TFR1 deficiency alters erythrocyte physiology in a similar way to dietary iron deficiency anemia, promoting intraerythrocytic parasite survival in mice.
Sun Nov 01 00:00:00 EDT 2015
In vivo hematopoietic Myc activation directs a transcriptional signature in endothelial cells within the bone marrow microenvironment.
Oncotarget
Franke K,Vilne B,Prazeres da Costa O,Rudelius M,Peschel C,Oostendorp RA,Keller U
47-0451 was used in Flow cytometry/Cell sorting to study the effect of Myc activation on the frequency of different hematopoietic stem/ progenitor cell subsets.
Tue Sep 08 00:00:00 EDT 2015
Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation.
Journal of neuroinflammation
Cherry JD,Olschowka JA,O'Banion MK
47-0451 was used in Flow cytometry/Cell sorting to examine microglial phenotypes during chronic neuroinflammation in relation to amyloid beta plaque deposition.
Wed Nov 04 00:00:00 EST 2015
A novel autosomal recessive TERT T1129P mutation in a dyskeratosis congenita family leads to cellular senescence and loss of CD34+ hematopoietic stem cells not reversible by mTOR-inhibition.
Aging
Stockklausner C,Raffel S,Klermund J,Bandapalli OR,Beier F,Brümmendorf TH,Bürger F,Sauer SW,Hoffmann GF,Lorenz H,Tagliaferri L,Nowak D,Hofmann WK,Buergermeister R,Kerber C,Rausch T,Korbel JO,Luke B,Trumpp A,Kulozik AE
47-0451 was used in Flow cytometry/Cell sorting to outline limitations of a potential dyskeratosis congenita therapy based on rapamycin.
Sun Nov 01 00:00:00 EDT 2015
Poly(I:C) and CpG-ODN combined aerosolization to treat lung metastases and counter the immunosuppressive microenvironment.
Oncoimmunology
Le Noci V,Tortoreto M,Gulino A,Storti C,Bianchi F,Zaffaroni N,Tripodo C,Tagliabue E,Balsari A,Sfondrini L
47-0451 was used in Flow cytometry/Cell sorting to evaluated aerosol delivery CpG-ODN combined with Poly(I:C) in the treatment of B16 melanoma lung metastases in C57BL/6 mice.
Thu Oct 01 00:00:00 EDT 2015
A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner.
Cancer discovery
Donohoe DR,Holley D,Collins LB,Montgomery SA,Whitmore AC,Hillhouse A,Curry KP,Renner SW,Greenwalt A,Ryan EP,Godfrey V,Heise MT,Threadgill DS,Han A,Swenberg JA,Threadgill DW,Bultman SJ
47-0451 was used in Flow cytometry/Cell sorting to assess whether dietary fiber is protective in colorectal cancer.
Mon Dec 01 00:00:00 EST 2014
Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development.
Developmental cell
Mizoguchi T,Pinho S,Ahmed J,Kunisaki Y,Hanoun M,Mendelson A,Ono N,Kronenberg HM,Frenette PS
47-0451 was used in Flow cytometry/Cell sorting to investigate the developmental origin of stromal cells, showing that osterix marks distinct waves of stromal progenitors during bone marrow development.
Mon May 12 00:00:00 EDT 2014
CD41 is a reliable identification and activation marker for murine basophils in the steady state and during helminth and malarial infections.
European journal of immunology
Bakocevic N,Claser C,Yoshikawa S,Jones LA,Chew S,Goh CC,Malleret B,Larbi A,Ginhoux F,de Lafaille MC,Karasuyama H,Renia L,Ng LG
47-0451 was used in Flow cytometry/Cell sorting to study the CD41 expression within basophils from the blood during both steady state and malarial inections within mice.
Sun Jun 01 00:00:00 EDT 2014
An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
White AJ,Jenkinson WE,Cowan JE,Parnell SM,Bacon A,Jones ND,Jenkinson EJ,Anderson G
47-0451 was used in Flow cytometry/Cell sorting to investigate whether thymus microenvironments are required in iNKT cell development, showing that medullary thymic epithelial cells are essential for intrathymic development of iNKT cells.
Sat Mar 15 00:00:00 EDT 2014
Genetic control of susceptibility to Candida albicans in SM/J mice.
Journal of immunology (Baltimore, Md. : 1950)
Radovanovic I,Leung V,Iliescu A,Bongfen SE,Mullick A,Langlais D,Gros P
47-0451 was used in Flow cytometry/Cell sorting to identify loci associated with increased susceptibility to infection by Candida albicans.
Fri Aug 01 00:00:00 EDT 2014
Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation.
Nature communications
Lin CC,Bradstreet TR,Schwarzkopf EA,Sim J,Carrero JA,Chou C,Cook LE,Egawa T,Taneja R,Murphy TL,Russell JH,Edelson BT
47-0451 was used in Flow cytometry/Cell sorting to study the factors affecting pathogenicity of TH cells in experimental autoimmune encephalomyelitis (EAE), showing that Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in EAE.
Thu Apr 03 00:00:00 EDT 2014
Mast cells play no role in the pathogenesis of postoperative ileus induced by intestinal manipulation.
PloS one
Gomez-Pinilla PJ,Farro G,Di Giovangiulio M,Stakenborg N,Némethova A,de Vries A,Liston A,Feyerabend TB,Rodewald HR,Boeckxstaens GE,Matteoli G
47-0451 was used in Flow cytometry/Cell sorting to investigate the role of mast cells in the development of postoperative ileus, showing that they play no role in the pathogenesis.
Tue Sep 02 00:00:00 EDT 2014
Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration.
Nature medicine
Lucas D,Scheiermann C,Chow A,Kunisaki Y,Bruns I,Barrick C,Tessarollo L,Frenette PS
47-0451 was used in Flow cytometry/Cell sorting to demonstrate the potential benefit of adrenergic nerve protection for shielding hematopoietic niches from injury.
Sat Jun 01 00:00:00 EDT 2013
Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria.
PLoS pathogens
Berghout J,Langlais D,Radovanovic I,Tam M,MacMicking JD,Stevenson MM,Gros P
47-0451 was used in Flow cytometry/Cell sorting to show that inactivation of Irf8 confers protection against the development of cerebral malaria.
Tue Feb 18 00:00:00 EST 2014
Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors.
European journal of immunology
Baik S,Jenkinson EJ,Lane PJ,Anderson G,Jenkinson WE
47-0451 was used in Flow cytometry/Cell sorting to reveal an unexpected overlap in the phenotypic properties of bipotent TECs with their lineage-restricted counterparts.
Fri Mar 01 00:00:00 EST 2013
CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Ehrentraut H,Clambey ET,McNamee EN,Brodsky KS,Ehrentraut SF,Poth JM,Riegel AK,Westrich JA,Colgan SP,Eltzschig HK
47-0451 was used in Flow cytometry/Cell sorting to determine how CD73-dependent adenosine generation in Tregs promotes ALI resolution.
Sat Jun 01 00:00:00 EDT 2013
Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Gattu AK,Swenson ES,Iwakiri Y,Samuel VT,Troiano N,Berry R,Church CD,Rodeheffer MS,Carpenter TO,Chung C
47-0451 was used in Flow cytometry/Cell sorting to assess the contribution of pigment epithelium-derived factor to mesenchymal stem cell fate.
Fri Nov 01 00:00:00 EDT 2013
Predictive computational modeling of the mucosal immune responses during Helicobacter pylori infection.
PloS one
Carbo A,Bassaganya-Riera J,Pedragosa M,Viladomiu M,Marathe M,Eubank S,Wendelsdorf K,Bisset K,Hoops S,Deng X,Alam M,Kronsteiner B,Mei Y,Hontecillas R
47-0451 was used in Flow cytometry/Cell sorting to investigate how CD4+ T-cells and other immune cell subsets are distributed in the gut mucosa during Helicobacter pylori infection.
Sat Jun 07 00:00:00 EDT 2014
Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla.
Journal of immunology (Baltimore, Md. : 1950)
Desanti GE,Cowan JE,Baik S,Parnell SM,White AJ,Penninger JM,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G
47-0451 was used in Flow cytometry/Cell sorting to study how multiple hemopoietic cell types regulate mTEC development through differential provision of RANKL/CD40L during ontogeny, revealing molecular differences in foetal and adult hemopoietic cross-talk.
Sat Dec 15 00:00:00 EST 2012
Granulocytes and vascularization regulate uterine bleeding and tissue remodeling in a mouse menstruation model.
PloS one
Menning A,Walter A,Rudolph M,Gashaw I,Fritzemeier KH,Roese L
47-0451 was used in Flow cytometry/Cell sorting to investigate mechanisms underlying pathogenesis of menstrual disorders, showing that granulocytes and vascularisation regulate uterine bleeding and tissue remodelling.
Thu Jan 10 00:00:00 EST 2013
