Product References
OTULIN protects the intestinal epithelium from apoptosis during inflammation and infection.
Cell death & disease
Verboom L,Anderson CJ,Jans M,Petta I,Blancke G,Martens A,Sze M,Hochepied T,Ravichandran KS,Vereecke L,van Loo G
56-0451-82 was used in Flow cytometry/Cell sorting to identify OTULIN as a major anti-apoptotic protein in the intestinal epithelium and provide mechanistic insights into how OTULIN deficiency drives gastrointestinal inflammation in ORAS patients.
Sat Aug 19 00:00:00 EDT 2023
ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jiang Y,Ma C,Hu Y,Yang Y,Ma C,Wu C,Liu L,Wen S,Moynagh PN,Wang B,Yang S
56-0451-82 was used in Flow cytometry/Cell sorting to demonstrate the important role of ECSIT in regulating YAP protein translation to control intestinal homeostasis and tumorigenesis.
Fri Sep 01 00:00:00 EDT 2023
An mRNA-based T-cell-inducing antigen strengthens COVID-19 vaccine against SARS-CoV-2 variants.
Nature communications
Tai W,Feng S,Chai B,Lu S,Zhao G,Chen D,Yu W,Ren L,Shi H,Lu J,Cai Z,Pang M,Tan X,Wang P,Lin J,Sun Q,Peng X,Cheng G
56-0451-82 was used in Flow cytometry/Cell sorting to demonstrate the necessity to strengthen the vaccine effectiveness by comprehensively stimulating both humoral and cellular responses, thereby offering insight for optimizing the design of COVID-19 vaccines.
Tue May 23 00:00:00 EDT 2023
Endothelial progenitor cells derived from embryonic stem cells prevent alveolar simplification in a murine model of bronchopulmonary dysplasia.
Frontiers in cell and developmental biology
Kolesnichenko OA,Flood HM,Zhang Y,Ustiyan V,Cuervo Jimenez HK,Kalin TV,Kalinichenko VV
56-0451-82 was used in Flow cytometry/Cell sorting to provide a proof-of-principle that cell therapy with ESC-derived c-KIT+FOXF1+ EPCs can prevent alveolar simplification in a hyperoxia-induced BPD mouse model.
Sat Jul 01 00:00:00 EDT 2023
CD11c+ microglia promote white matter repair after ischemic stroke.
Cell death & disease
Jia J,Zheng L,Ye L,Chen J,Shu S,Xu S,Bao X,Xia S,Liu R,Xu Y,Zhang M
56-0451-82 was used in Flow cytometry/Cell sorting to suggest that spontaneous white matter repair occurs after ischemic stroke, while CD11c+ microglia play critical roles in this white matter restorative progress.
Fri Feb 24 00:00:00 EST 2023
Inhibition of antiapoptotic BCL-2 proteins with ABT-263 induces fibroblast apoptosis, reversing persistent pulmonary fibrosis.
JCI insight
Cooley JC,Javkhlan N,Wilson JA,Foster DG,Edelman BL,Ortiz LA,Schwartz DA,Riches DW,Redente EF
56-0451-82 was used in Flow cytometry/Cell sorting to demonstrate that antiapoptotic BCL-2 family members are expressed by fibroblasts in both human and murine progressive fibrotic lung disease, that these fibroblasts are highly primed, and that treatment with ABT-263 induced fibroblast apoptosis and reduced fibrosis in 2 preclinical models of PF-ILD.
Wed Feb 08 00:00:00 EST 2023
Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer.
Journal of pharmaceutical analysis
Sun X,Zhou L,Wang Y,Deng G,Cao X,Ke B,Wu X,Gu Y,Cheng H,Xu Q,Du Q,Chen H,Sun Y
56-0451-82 was used in Flow cytometry/Cell sorting to provide new insights into the anti-tumor effects of CBD.
Sat Jul 01 00:00:00 EDT 2023
Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes.
Nature
Maschalidi S,Mehrotra P,Keçeli BN,De Cleene HKL,Lecomte K,Van der Cruyssen R,Janssen P,Pinney J,van Loo G,Elewaut D,Massie A,Hoste E,Ravichandran KS
56-0451-82 was used in Flow cytometry/Cell sorting to reveal that the membrane transporter SLC7A11 acts as a molecular brake on efferocytosis, the process by which dying cells are removed, and that inhibiting SLC7A11 function can accelerate wound healing.
Wed Jun 01 00:00:00 EDT 2022
IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence.
Nature communications
Chiang HY,Lu HH,Sudhakar JN,Chen YW,Shih NS,Weng YT,Shui JW
56-0451-82 was used in Flow Cytometry to conclude that IL-18 in return regulates Stat3-mediated anti-microbial response in Paneth cells, Akt-Tcf4-triggered expansion of Lgr5+ stem cells to facilitate tissue repair, and AIEC clearance by promoting IFNγ+ T cells.
Tue Feb 15 00:00:00 EST 2022
NF-κB-inducing kinase (NIK) is activated in pancreatic β-cells but does not contribute to the development of diabetes.
Cell death & disease
Xiao P,Takiishi T,Violato NM,Licata G,Dotta F,Sebastiani G,Marselli L,Singh SP,Sze M,Van Loo G,Dejardin E,Gurzov EN,Cardozo AK
56-0451-82 was used in Flow cytometry/Cell sorting to suggest that NIK activation is dispensable for the development of diabetes.
Thu May 19 00:00:00 EDT 2022
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Ma C,Li S,Hu Y,Ma Y,Wu Y,Wu C,Liu X,Wang B,Hu G,Zhou J,Yang S
56-0451 was used in Flow cytometry/Cell sorting to identify a new role for AIM2 in controlling the onset of EAE.
Mon May 03 00:00:00 EDT 2021
Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia.
Molecular psychiatry
Ledo JH,Liebmann T,Zhang R,Chang JC,Azevedo EP,Wong E,Silva HM,Troyanskaya OG,Bustos V,Greengard P
56-0451 was used in Flow cytometry/Cell sorting to demonstrate a novel mechanism by which PS1 modulates microglial function and contributes to Alzheimer's -associated phenotypes.
Fri Oct 01 00:00:00 EDT 2021
Polarization of Type 1 Macrophages Is Associated with the Severity of Viral Encephalitis Caused by Japanese Encephalitis Virus and Dengue Virus.
Cells
Jhan MK,Chen CL,Shen TJ,Tseng PC,Wang YT,Satria RD,Yu CY,Lin CF
56-0451-82 was used in Flow cytometry/Cell sorting to show that flavivirus infection, such as JEV and DENV, promoted type 1 macrophage polarization in the brain associated with encephalitic severity.
Mon Nov 15 00:00:00 EST 2021
Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements.
Cell reports
Symeonidou V,Jakobczyk H,Bashanfer S,Malouf C,Fotopoulou F,Kotecha RS,Anderson RA,Finch AJ,Ottersbach K
56-0451-82 was used in Flow Cytometry to define a conserved fetal transcriptional signature characterized by a prominent proliferative and oncogenic nature that persists in infant ALL blasts.
Tue Oct 26 00:00:00 EDT 2021
TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling.
Cell reports
Agarwal P,Li H,Choi K,Hueneman K,He J,Welner RS,Starczynowski DT,Bhatia R
56-0451-82 was used in Flow Cytometry to find that TNF-α-mediated alterations in CML BM stromal niches enhance support of LSC maintenance and growth via CXCL1-CXCR2 signaling and that CXCR2 inhibition effectively depletes CML LSCs.
Tue Jul 13 00:00:00 EDT 2021
Mesenchymal stem cells attenuate liver fibrosis by targeting Ly6Chi/lo macrophages through activating the cytokine-paracrine and apoptotic pathways.
Cell death discovery
Li YH,Shen S,Shao T,Jin MT,Fan DD,Lin AF,Xiang LX,Shao JZ
56-0451-82 was used in Flow Cytometry to provide insights into the functional role of bone marrow-derived sesenchymal stem cell in alleviating liver fibrosis.
Mon Sep 13 00:00:00 EDT 2021
The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching.
Immunity
Xu J,Zanvit P,Hu L,Tseng PY,Liu N,Wang F,Liu O,Zhang D,Jin W,Guo N,Han Y,Yin J,Cain A,Hoon MA,Wang S,Chen W
56-0451 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying itching associated with cutaneous wound healing, focusing on the contribution of soluble factors released during healing.
Tue Aug 18 00:00:00 EDT 2020
Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair.
Cell stem cell
Shook BA,Wasko RR,Mano O,Rutenberg-Schoenberg M,Rudolph MC,Zirak B,Rivera-Gonzalez GC,López-Giráldez F,Zarini S,Rezza A,Clark DA,Rendl M,Rosenblum MD,Gerstein MB,Horsley V
56-0451-82 was used in Flow Cytometry to identify an essential role for adipocyte lipolysis in regulating inflammation and repair after injury in skin.
Thu Jun 04 00:00:00 EDT 2020
Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation.
The Journal of experimental medicine
Devos M,Tanghe G,Gilbert B,Dierick E,Verheirstraeten M,Nemegeer J,de Reuver R,Lefebvre S,De Munck J,Rehwinkel J,Vandenabeele P,Declercq W,Maelfait J
56-0451 was used in Flow cytometry/Cell sorting to show that sensing of endogenous nucleic acids by ZBP1 is critical in driving skin pathology characterised by antiviral and IL-17 immune responses.
Mon Jul 06 00:00:00 EDT 2020
PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-Induced Pathological Vascular Fibrosis and Remodeling-Brief Report.
Arteriosclerosis, thrombosis, and vascular biology
Lu S,Strand KA,Mutryn MF,Tucker RM,Jolly AJ,Furgeson SB,Moulton KS,Nemenoff RA,Weiser-Evans MCM
56-0451 was used in Flow cytometry/Cell sorting to show treatment of pathological vascular fibrosis could be mediated by pharmacological upregulation of PTEN.
Sat Feb 01 00:00:00 EST 2020
Maternal obesity increases offspring's mammary cancer recurrence and impairs tumor immune response.
Endocrine-related cancer
Zhang X,de Oliveira Andrade F,Zhang H,Cruz I,Clarke R,Gaur P,Verma V,Hilakivi-Clarke L
56-0451 was used in Flow cytometry/Cell sorting to study if maternal obesity-inducing high fat diet (HFD) not only increases offspring's mammary cancer risk but also impairs response to antiestrogen tamoxifen.
Tue Sep 01 00:00:00 EDT 2020
IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network.
Journal of immunology (Baltimore, Md. : 1950)
Sun L,Girnary M,Wang L,Jiao Y,Zeng E,Mercer K,Zhang J,Marchesan JT,Yu N,Moss K,Lei YL,Offenbacher S,Zhang S
56-0451 was used in Flow cytometry/Cell sorting to determine the effects of IL-10 on IL-17-mediated periodontitis-associated inflammatory networks.
Wed Apr 15 00:00:00 EDT 2020
Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.
Scientific reports
Alkhani A,Levy CS,Tsui M,Rosenberg KA,Polovina K,Mattis AN,Mack M,Van Dyken S,Wang BM,Maher JJ,Nijagal A
56-0451 was used in Flow cytometry/Cell sorting to demonstrate that Ly6cLo non-classical monocytes promote resolution of RRV-mediated perinatal liver infammation in both the physiologic environment of the late gestation fetus, and in the neonatal pup.
Tue Apr 28 00:00:00 EDT 2020
Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy.
Journal for immunotherapy of cancer
Gao H,Wu Y,Shi J,Zhang X,Liu T,Hu B,Jia B,Wan Y,Liu Z,Wang F
56-0451 was used in Flow cytometry/Cell sorting to demonstrate that 99mTc-MY1523 SPECT/CT allowed a real-time, quantitative and dynamic mapping of PD-L1 expression in vivo, and the imaging-guided PD-L1 blockade immunotherapy significantly enhanced the therapeutic efficacy.
Sun Nov 01 00:00:00 EDT 2020
Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development.
PloS one
Ledo JH,Zhang R,Mesin L,Mourão-Sá D,Azevedo EP,Troyanskaya OG,Bustos V,Greengard P
56-0451 was used in Flow cytometry/Cell sorting to show that PS1 functional connections appear through interaction hubs at Pu.1, Irf8 and Rela-p65 transcription factors.
Tue Oct 13 00:00:00 EDT 2020
Protocol for Flow Cytometric Detection of Immune Cell Infiltration in the Epidermis and Dermis of a Psoriasis Mouse Model.
STAR protocols
Lou F,Sun Y,Wang H
56-0451-82 was used in Flow Cytometry to establish a mouse model of psoriasis and flow cytometric detection of immune cells in the inflamed epidermis and dermis.
Fri Dec 18 00:00:00 EST 2020
Resolving Fates and Single-Cell Transcriptomes of Hematopoietic Stem Cell Clones by PolyloxExpress Barcoding.
Cell stem cell
Pei W,Shang F,Wang X,Fanti AK,Greco A,Busch K,Klapproth K,Zhang Q,Quedenau C,Sauer S,Feyerabend TB,Höfer T,Rodewald HR
56-0451 was used in Flow cytometry/Cell sorting to develop the PolyloxExpress allele, enabling Cre-recombinase-dependent RNA barcoding in situ.
Thu Sep 03 00:00:00 EDT 2020
CNS Immune Profiling in a Dengue Virus-Infected Immunocompetent Outbred ICR Mice Strain.
Frontiers in cellular and infection microbiology
Shen TJ,Chen CL,Jhan MK,Tseng PC,Lin CF
56-0451 was used in Flow cytometry/Cell sorting to indicate a CNS immune profile of DENV infection and hypothetical CNS immunity in response to DENV infection.
Thu Jun 17 00:00:00 EDT 2021
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine.
Nature communications
Campesato LF,Budhu S,Tchaicha J,Weng CH,Gigoux M,Cohen IJ,Redmond D,Mangarin L,Pourpe S,Liu C,Zappasodi R,Zamarin D,Cavanaugh J,Castro AC,Manfredi MG,McGovern K,Merghoub T,Wolchok JD
56-0451 was used in Flow cytometry/Cell sorting to show that the AHR pathway is selectively active in IDO/TDO-overexpressing tumors and is associated with resistance to immune checkpoint inhibitors.
Tue Aug 11 00:00:00 EDT 2020
Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas.
Nature communications
Sudhakar JN,Lu HH,Chiang HY,Suen CS,Hwang MJ,Wu SY,Shen CN,Chang YM,Li FA,Liu FT,Shui JW
56-0451 was used in Flow cytometry/Cell sorting to show in gut epithelial cells, galectin-9 is enriched in lysosomes and predominantly binds to lysosome-associated membrane protein 2 (Lamp2) in a Asn(N)-glycan dependent manner.
Thu Aug 27 00:00:00 EDT 2020
Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow.
Immunity
Walker JA,Clark PA,Crisp A,Barlow JL,Szeto A,Ferreira ACF,Rana BMJ,Jolin HE,Rodriguez-Rodriguez N,Sivasubramaniam M,Pannell R,Cruickshank J,Daly M,Haim-Vilmovsky L,Teichmann SA,McKenzie ANJ
56-0451 was used in Flow cytometry/Cell sorting to identify a discrete ILC2-committed population and delineated transition states between early progenitors and a highly heterogeneous ILC1, ILC3, and NK precursor cell cluster.
Tue Jul 16 00:00:00 EDT 2019
Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche.
Immunity
Bonnardel J,T'Jonck W,Gaublomme D,Browaeys R,Scott CL,Martens L,Vanneste B,De Prijck S,Nedospasov SA,Kremer A,Van Hamme E,Borghgraef P,Toussaint W,De Bleser P,Mannaerts I,Beschin A,van Grunsven LA,Lambrecht BN,Taghon T,Lippens S,Elewaut D,Saeys Y,Guilliams M
56-0451-82 was used in Flow Cytometry to show that the Kupffer cell niche is composed of stellate cells, hepatocytes, and endothelial cells that together imprint the liver-specific macrophage identity.
Tue Oct 15 00:00:00 EDT 2019
Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.
Cell host & microbe
Leech JM,Dhariwala MO,Lowe MM,Chu K,Merana GR,Cornuot C,Weckel A,Ma JM,Leitner EG,Gonzalez JR,Vasquez KS,Diep BA,Scharschmidt TC
56-0451-82 was used in Flow cytometry/Cell sorting to study how skin colonization by commensal Staphylococcus epidermidis facilitates immune tolerance preferentially in neonates via induction of antigen-specific regulatory T cells.
Wed Dec 11 00:00:00 EST 2019
Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells.
Cell stem cell
Agarwal P,Isringhausen S,Li H,Paterson AJ,He J,Gomariz Á,Nagasawa T,Nombela-Arrieta C,Bhatia R
56-0451-82 was used in Flow Cytometry to highlight a critical role of niche-specific effects of Cxcl12 expression in maintaining quiescence of TKI-resistant LSC populations.
Thu May 02 00:00:00 EDT 2019
SIRT1 regulates metabolism and leukemogenic potential in CML stem cells.
The Journal of clinical investigation
Abraham A,Qiu S,Chacko BK,Li H,Paterson A,He J,Agarwal P,Shah M,Welner R,Darley-Usmar VM,Bhatia R
56-0451 was used in Flow cytometry/Cell sorting to demonstrate an important role for SIRT1 in leukemia development.
Mon Jun 10 00:00:00 EDT 2019
Inhibition of EphB4-Ephrin-B2 Signaling Reprograms the Tumor Immune Microenvironment in Head and Neck Cancers.
Cancer research
Bhatia S,Oweida A,Lennon S,Darragh LB,Milner D,Phan AV,Mueller AC,Van Court B,Raben D,Serkova NJ,Wang XJ,Jimeno A,Clambey ET,Pasquale EB,Karam SD
56-0451 was used in Flow cytometry/Cell sorting to show EphB4-ephrin-B2 inhibition displayed tumor growth suppression, indicating a possible alternative for those that cannot receive anti-PDL1 therapy.
Wed May 15 00:00:00 EDT 2019
CSF1R antagonism limits local restimulation of antiviral CD8+ T cells during viral encephalitis.
Journal of neuroinflammation
Funk KE,Klein RS
56-0451 was used in Flow cytometry/Cell sorting to highlight the impact of colony-stimulating factor 1 receptor antagonism on APC activation in the CNS and periphery and the importance of microglia in orchestrating the CNS immune response following neurotropic viral infection.
Thu Jan 31 00:00:00 EST 2019
Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti-PD-1 response in NSCLC.
Life science alliance
Bullock BL,Kimball AK,Poczobutt JM,Neuwelt AJ,Li HY,Johnson AM,Kwak JW,Kleczko EK,Kaspar RE,Wagner EK,Hopp K,Schenk EL,Weiser-Evans MC,Clambey ET,Nemenoff RA
56-0451-82 was used in Flow Cytometry to demonstrate that targeted enhancement of tumor-intrinsic IFNγ signaling can induce a cascade of changes associated with increased therapeutic vulnerability.
Sat Jun 01 00:00:00 EDT 2019
Dietary calories and lipids synergistically shape adipose tissue cellularity during postnatal growth.
Molecular metabolism
Meln I,Wolff G,Gajek T,Koddebusch J,Lerch S,Harbrecht L,Hong W,Bayindir-Buchhalter I,Krunic D,Augustin HG,Vegiopoulos A
56-0451-82 was used in Flow cytometry/Cell sorting to show that dietary lipids and calories differentially and synergistically drive adipose tissue proliferative growth and the programming of the metabolic syndrome in childhood.
Sat Jun 01 00:00:00 EDT 2019
A natural killer-dendritic cell axis defines checkpoint therapy-responsive tumor microenvironments.
Nature medicine
Barry KC,Hsu J,Broz ML,Cueto FJ,Binnewies M,Combes AJ,Nelson AE,Loo K,Kumar R,Rosenblum MD,Alvarado MD,Wolf DM,Bogunovic D,Bhardwaj N,Daud AI,Ha PK,Ryan WR,Pollack JL,Samad B,Asthana S,Chan V,Krummel MF
56-0451 was used in Flow cytometry/Cell sorting to reveal that innate immune stimulatory dendritic cells and natural killer cells cluster together as an excellent prognostic tool for T cell-directed immunotherapy and that these innate cells are necessary for enhanced T cell tumor responses, suggesting this axis as a target for new therapies.
Wed Aug 01 00:00:00 EDT 2018
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.
Immunity
Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC
56-0451 was used in Immunohistochemistry to indicate that the VHL-HIF-glycolysis axis is essential for the late-stage maturation and function of ILC2s via targeting IL-33-ST2 pathway.
Tue Feb 20 00:00:00 EST 2018
Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression.
Cancer research
Kwak JW,Laskowski J,Li HY,McSharry MV,Sippel TR,Bullock BL,Johnson AM,Poczobutt JM,Neuwelt AJ,Malkoski SP,Weiser-Evans MC,Lambris JD,Clambey ET,Thurman JM,Nemenoff RA
56-0451 was used in Flow cytometry/Cell sorting to study the mechanism relating complement activation to tumour progression in multiple immunocompetent orthotopic models of lung cancer.
Mon Jan 01 00:00:00 EST 2018
Quantification of airway fibrosis in asthma by flow cytometry.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Reichard A,Wanner N,Stuehr E,Alemagno M,Weiss K,Queisser K,Erzurum S,Asosingh K
56-0451 was used in Flow cytometry to develop a novel method to quantify myofibroblast collagen expression in asthmatic lungs.
Sun Jul 01 00:00:00 EDT 2018
Group 2 innate lymphoid cells protect lung endothelial cells from pyroptosis in sepsis.
Cell death & disease
Lai D,Tang J,Chen L,Fan EK,Scott MJ,Li Y,Billiar TR,Wilson MA,Fang X,Shu Q,Fan J
56-0451 was used in Flow cytometry/Cell sorting to describe the function of ILC2 in the regulation of lung inflammation by protecting lung endothelial cell from pyroptosis.
Tue Mar 06 00:00:00 EST 2018
Integrin CD11b activation drives anti-tumor innate immunity.
Nature communications
Schmid MC,Khan SQ,Kaneda MM,Pathria P,Shepard R,Louis TL,Anand S,Woo G,Leem C,Faridi MH,Geraghty T,Rajagopalan A,Gupta S,Ahmed M,Vazquez-Padron RI,Cheresh DA,Gupta V,Varner JA
56-0451 was used in Flow cytometry/Cell sorting to identify CD11b as a negative regulator of immune suppression and a target for cancer immune therapy.
Wed Dec 19 00:00:00 EST 2018
Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation.
Cell
Ali N,Zirak B,Rodriguez RS,Pauli ML,Truong HA,Lai K,Ahn R,Corbin K,Lowe MM,Scharschmidt TC,Taravati K,Tan MR,Ricardo-Gonzalez RR,Nosbaum A,Bertolini M,Liao W,Nestle FO,Paus R,Cotsarelis G,Abbas AK,Rosenblum MD
56-0451 was used in Flow cytometry/Cell sorting to study the role of regulatory T cells in hair follicles and hair follicle stem cell biology.
Thu Jun 01 00:00:00 EDT 2017
Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.
Cell host & microbe
Scharschmidt TC,Vasquez KS,Pauli ML,Leitner EG,Chu K,Truong HA,Lowe MM,Sanchez Rodriguez R,Ali N,Laszik ZG,Sonnenburg JL,Millar SE,Rosenblum MD
56-0451 was used in Flow cytometry/Cell sorting to show that hair follicle (HF) development facilitates the accumulation of regulatory T cells in neonatal skin and that upon skin entry these cells localise to HFs.
Wed Apr 12 00:00:00 EDT 2017
IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model.
PLoS medicine
Xu J,Guardado J,Hoffman R,Xu H,Namas R,Vodovotz Y,Xu L,Ramadan M,Brown J,Turnquist HR,Billiar TR
56-0451 was used in Flow cytometry/Cell sorting to suggest that IL33 may initiate early detrimental type 2 immune responses after trauma through ILC2 regulation of neutrophil IL5 production.
Sat Jul 01 00:00:00 EDT 2017
Hypoxia-Inducible Factor 1α Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury.
The American journal of pathology
McClendon J,Jansing NL,Redente EF,Gandjeva A,Ito Y,Colgan SP,Ahmad A,Riches DWH,Chapman HA,Mason RJ,Tuder RM,Zemans RL
56-0451 was used in Flow cytometry/Cell sorting to study whether hypoxia-inducible factor 1α promotes proliferation and spreading of alveolar type II cells during repair after lung injury.
Tue Aug 01 00:00:00 EDT 2017
Ionizing radiation sensitizes tumors to PD-L1 immune checkpoint blockade in orthotopic murine head and neck squamous cell carcinoma.
Oncoimmunology
Oweida A,Lennon S,Calame D,Korpela S,Bhatia S,Sharma J,Graham C,Binder D,Serkova N,Raben D,Heasley L,Clambey E,Nemenoff R,Karam SD
56-0451 was used in Flow cytometry/Cell sorting to investigate whether local radiation can transform the tumour immune landscape and render poorly immunogenic head and neck squamous cell carcinoma tumours sensitive to PD-L1 inhibition.
Fri Apr 08 00:00:00 EDT 2022
Myeloid Wnt ligands are required for normal development of dermal lymphatic vasculature.
PloS one
Muley A,Odaka Y,Lewkowich IP,Vemaraju S,Yamaguchi TP,Shawber C,Dickie BH,Lang RA
56-0451 was used in Flow cytometry/Cell sorting to establish that Wnt ligands from macrophages play an important role in development of the lymphatic capillary vessels.
Thu Oct 19 00:00:00 EDT 2017
Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment.
The Journal of clinical investigation
Starobinets H,Ye J,Broz M,Barry K,Goldsmith J,Marsh T,Rostker F,Krummel M,Debnath J
56-0451 was used in Flow cytometry/Cell sorting to evaluate how autophagy inhibition impacts the antitumor immune response in immune-competent mouse models of melanoma and mammary cancer.
Thu Dec 01 00:00:00 EST 2016
β-Catenin Stabilization in Skin Fibroblasts Causes Fibrotic Lesions by Preventing Adipocyte Differentiation of the Reticular Dermis.
The Journal of investigative dermatology
Mastrogiannaki M,Lichtenberger BM,Reimer A,Collins CA,Driskell RR,Watt FM
56-0451 was used in Flow cytometry/Cell sorting to study how Wnt/β-catenin signalling may control adipogenic cell fate within the lower dermis, which potentially contributes to the pathogenesis of fibrotic skin diseases.
Wed Jun 01 00:00:00 EDT 2016
DUX4 induces a transcriptome more characteristic of a less-differentiated cell state and inhibits myogenesis.
Journal of cell science
Knopp P,Krom YD,Banerji CR,Panamarova M,Moyle LA,den Hamer B,van der Maarel SM,Zammit PS
56-0451 was used in Flow cytometry/Cell sorting to investigate the role of DUX4 in the inhibition of myogenesis and in facioscapulohumeral muscular dystrophy.
Sat Oct 15 00:00:00 EDT 2016
The Use of Toll-like Receptor 4 Agonist to Reshape the Immune Signature in Ovarian Cancer.
Anticancer research
Vindevogel E,Baert T,VAN Hoylandt A,Verbist G,Vande Velde G,Garg AD,Agostinis P,Vergote I,Coosemans AN
56-0451 was used in Flow cytometry/Cell sorting to investigate whether LPS is a beneficial adjuvant in dendritic cell mono-immunotherapy of ovarian cancer.
Tue Nov 01 00:00:00 EDT 2016
Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.
Cell reports
Barrett NA,Malouf C,Kapeni C,Bacon WA,Giotopoulos G,Jacobsen SEW,Huntly BJ,Ottersbach K
56-0451 was used in Flow cytometry/Cell sorting to elucidate the contribution of MII-AF4 in B cell acute lymphoblastic leukaemia early development in the mouse embryo.
Tue Jul 26 00:00:00 EDT 2016
The ontogeny of Butyrophilin-like (Btnl) 1 and Btnl6 in murine small intestine.
Scientific reports
Lebrero-Fernández C,Bas-Forsberg A
56-0451 was used in Flow cytometry/Cell sorting to show that the expression of Btnl1 and Btnl6 is delayed in the murine neonatal gut.
Tue Aug 16 00:00:00 EDT 2016
KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.
Nature medicine
Shankman LS,Gomez D,Cherepanova OA,Salmon M,Alencar GF,Haskins RM,Swiatlowska P,Newman AA,Greene ES,Straub AC,Isakson B,Randolph GJ,Owens GK
56-0451 was used in Flow cytometry/Cell sorting to show how KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.
Mon Jun 01 00:00:00 EDT 2015
Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.
Nature neuroscience
Haines JD,Herbin O,de la Hera B,Vidaurre OG,Moy GA,Sun Q,Fung HY,Albrecht S,Alexandropoulos K,McCauley D,Chook YM,Kuhlmann T,Kidd GJ,Shacham S,Casaccia P
56-0451 was used in Flow cytometry/Cell sorting to reveal that CRM1 inhibitors have the ability to modulate the export of molecules associated with both axonal damage and also neuroprotection.
Wed Apr 01 00:00:00 EDT 2015
The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity.
Nature communications
Sag D,Cekic C,Wu R,Linden J,Hedrick CC
56-0451 was used in Flow cytometry/Cell sorting to demonstrate that the absence of ABCG1 inhibits tumour growth through modulation of macrophage function within the tumour.
Fri Feb 27 00:00:00 EST 2015
Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.
Nature communications
Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W
56-0451 was used in Flow cytometry/Cell sorting to show that the addition of antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.
Tue Sep 29 00:00:00 EDT 2015
Type 1 diabetes in NOD mice unaffected by mast cell deficiency.
Diabetes
Gutierrez DA,Fu W,Schonefeldt S,Feyerabend TB,Ortiz-Lopez A,Lampi Y,Liston A,Mathis D,Rodewald HR
56-0451 was used in Flow cytometry/Cell sorting to investigate the role of mast cells in the onset and incidence of type 1 diabetes, showing that mast cell deficiency does not affect diabetes.
Sat Nov 01 00:00:00 EDT 2014
Dynamic changes in macrophage activation and proliferation during the development and resolution of intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Little MC,Hurst RJ,Else KJ
56-0451 was used in Flow cytometry/Cell sorting to study intestinal inflammation and the dynamic changes in macrophage activation and proliferation that occur during this process.
Sat Nov 01 00:00:00 EDT 2014
BMP pathway regulation of and by macrophages.
PloS one
Talati M,West J,Zaynagetdinov R,Hong CC,Han W,Blackwell T,Robinson L,Blackwell TS,Lane K
56-0451 was used in Flow cytometry/Cell sorting to investigate the impact of BMPR2 mutations on SMAD signalling.
Tue Jan 06 00:00:00 EST 2015
Peripheral elevation of TNF-α leads to early synaptic abnormalities in the mouse somatosensory cortex in experimental autoimmune encephalomyelitis.
Proceedings of the National Academy of Sciences of the United States of America
Yang G,Parkhurst CN,Hayes S,Gan WB
56-0451 was used in Flow cytometry/Cell sorting to examine the effect of inflammation and cytokine elevation on synaptic connections in the primary somatosensory cortex in a mouse model of EAE.
Tue Jun 18 00:00:00 EDT 2013
Isolation, characterization, and transplantation of cardiac endothelial cells.
BioMed research international
Pratumvinit B,Reesukumal K,Janebodin K,Ieronimakis N,Reyes M
56-0451 was used in Flow cytometry/Cell sorting to develop a method to expand the study of endothelial cell biology for multiple clinical applications..
Tue Jun 17 00:00:00 EDT 2014
IL-33 induces innate lymphoid cell-mediated airway inflammation by activating mammalian target of rapamycin.
The Journal of allergy and clinical immunology
Salmond RJ,Mirchandani AS,Besnard AG,Bain CC,Thomson NC,Liew FY
56-0451 was used in Flow cytometry/Cell sorting to investigate the role of mTOR signalling in the activation of TH2, ILC and IL-33 inflammation responses.
Thu Nov 01 00:00:00 EDT 2012
Non-invasive longitudinal imaging of tumor progression using an (111)indium labeled CXCR4 peptide antagonist.
American journal of nuclear medicine and molecular imaging
Buckle T,van Berg NS,Kuil J,Bunschoten A,Oldenburg J,Borowsky AD,Wesseling J,Masada R,Oishi S,Fujii N,van Leeuwen FW
56-0451 was used in Flow cytometry/Cell sorting to elucidate a therapeutic approach to attenuate fibrosis by specifically targeting TβRI kinase in LOXL2-expressing cells.
Thu Nov 08 00:00:00 EST 2012
Tonic BCR signaling represses receptor editing via Raf- and calcium-dependent signaling pathways.
Immunology letters
Ramsey LB,Vegoe AL,Miller AT,Cooke MP,Farrar MA
56-0451 was used in Flow cytometry/Cell sorting to provide evidence that enhanced BCR signalling at the immature B cell stage of development suppresses light chain receptor editing.
Wed Mar 30 00:00:00 EDT 2011
Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.
Blood
Böiers C,Buza-Vidas N,Jensen CT,Pronk CJ,Kharazi S,Wittmann L,Sitnicka E,Hultquist A,Jacobsen SE
56-0451 was used in Flow cytometry/Cell sorting to investigate the role of FLT3 in early granulocyte-monocyte progenitors (GMPs), showing that most GMPs are derived from FLT3-expressing progenitors.
Thu Jun 17 00:00:00 EDT 2010
