Product References
Soluble NKG2D ligands impair CD8+ T cell antitumor function dependent of NKG2D downregulation in neuroblastoma.
Oncology letters
Zhang Y,Luo F,Dong K
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 14-1079-80) in Flow Cytometry
Sat Jul 01 00:00:00 EDT 2023
Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling.
The Journal of clinical investigation
Ding L,Chen X,Zhang W,Dai X,Guo H,Pan X,Xu Y,Feng J,Yuan M,Gao X,Wang J,Xu X,Li S,Wu H,Cao J,He Q,Yang B
14-1079-80 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to identify a regulator of cell surface PD-L1, provides a ready-to-use small-molecule drug for PD-L1 degradation, and highlights a potential therapeutic target to overcome immune evasion by tumor cells.
Tue Jan 03 00:00:00 EST 2023
A Novel Late-Stage Autophagy Inhibitor That Efficiently Targets Lysosomes Inducing Potent Cytotoxic and Sensitizing Effects in Lung Cancer.
Cancers
Molero-Valenzuela A,Fontova P,Alonso-Carrillo D,Carreira-Barral I,Torres AA,García-Valverde M,Benítez-García C,Pérez-Tomás R,Quesada R,Soto-Cerrato V
14-1079-80 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to design a novel potent anionophore compound that specifically targets lysosomes, called LAI-1 (late-stage autophagy inhibitor-1), and evaluated its role in blocking autophagy and its potential anticancer effects in three lung cancer cell lines from different histological subtypes.
Tue Jul 12 00:00:00 EDT 2022
Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab.
Signal transduction and targeted therapy
Zheng G,Guo Z,Li W,Xi W,Zuo B,Zhang R,Wen W,Yang AG,Jia L
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 14-1079-80) in Flow Cytometry
Wed Jun 23 00:00:00 EDT 2021
Efficient Protein Transfection by Swarms of Chemically Powered Plasmonic Virus-Sized Nanorobots.
ACS nano
Ressnerova A,Novotny F,Michalkova H,Pumera M,Adam V,Heger Z
14-1079-80 was used in Immunocytochemistry-immunoflourescence to show that protein transfection mediated by such nanorobots is an important step forward, challenging the field of nanomedicine and having potential in future translational medical research.
Tue Aug 24 00:00:00 EDT 2021
Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy.
Cell death and differentiation
Humbert M,Seiler K,Mosimann S,Rentsch V,Sharma K,Pandey AV,McKenna SL,Tschan MP
14-1079-80 was used in Immunocytochemistry to understand the role of autophagy in granulocytic differentiation and to define key druggable autophagy targets in this process.
Sun Aug 01 00:00:00 EDT 2021
Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy.
Cell death and differentiation
Humbert M,Seiler K,Mosimann S,Rentsch V,Sharma K,Pandey AV,McKenna SL,Tschan MP
14-1079-80 was used in Immunocytochemistry to understand the role of autophagy in granulocytic differentiation and to define key druggable autophagy targets in this process.
Sun Aug 01 00:00:00 EDT 2021
Circulating prostate cancer cells have differential resistance to fluid shear stress-induced cell death.
Journal of cell science
Hope JM,Bersi MR,Dombroski JA,Clinch AB,Pereles RS,Merryman WD,King MR
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 14-1079-80) in Flow Cytometry
Mon Feb 22 00:00:00 EST 2021
Exosomes in serum‑free cultures of THP‑1 macrophages infected with Mycobacterium tuberculosis.
Molecular medicine reports
Biadglegne F,Rademacher P,De Sulbaran YGJ,König B,Rodloff AC,Zedler U,Dorhoi A,Sack U
14-1079-80 was used in Western Blotting to characterize exosomes released from THP‚1 macrophages cultured in serum‚free, ultra‚centrifuged medium upon infection with the human pathogen Mycobacterium tuberculosis (Mtb).
Mon Nov 01 00:00:00 EDT 2021
Exosomes in serum‑free cultures of THP‑1 macrophages infected with Mycobacterium tuberculosis.
Molecular medicine reports
Biadglegne F,Rademacher P,De Sulbaran YGJ,König B,Rodloff AC,Zedler U,Dorhoi A,Sack U
14-1079-80 was used in Western Blotting to characterize exosomes released from THP‚1 macrophages cultured in serum‚free, ultra‚centrifuged medium upon infection with the human pathogen Mycobacterium tuberculosis (Mtb).
Mon Nov 01 00:00:00 EDT 2021
Analysis of the intracellular traffic of IgG in the context of Down syndrome (trisomy 21).
Scientific reports
Cejas RB,Tamaño-Blanco M,Blanco JG
14-1079-80 was used in Immunocytochemistry to analyse the intracellular traffic of IgG mediated by the human neonatal Fc receptor (FcRn) in fibroblast cell lines with trisomy 21.
Wed May 26 00:00:00 EDT 2021
Analysis of the intracellular traffic of IgG in the context of Down syndrome (trisomy 21).
Scientific reports
Cejas RB,Tamaño-Blanco M,Blanco JG
14-1079-80 was used in Immunocytochemistry to analyse the intracellular traffic of IgG mediated by the human neonatal Fc receptor (FcRn) in fibroblast cell lines with trisomy 21.
Wed May 26 00:00:00 EDT 2021
Spatial and temporal VEGF receptor intracellular trafficking in microvascular and macrovascular endothelial cells.
Scientific reports
Silva JAF,Qi X,Grant MB,Boulton ME
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 14-1079-80) in Immunocytochemistry
Mon Aug 30 00:00:00 EDT 2021
Multiple Immunostainings with Different Epitope Retrievals-The FOLGAS Protocol.
International journal of molecular sciences
von Schoenfeld A,Bronsert P,Poc M,Fuller A,Filby A,Kraft S,Kurowski K,Sörensen K,Huber J,Pfeiffer J,Proietti M,Stehl V,Werner M,Seidl M
14-1079-80 was used in Immunohistochemistry to describe a sequential multistaining protocol for immunohistochemistry, immunofluorescence and CyTOF imaging for formalin-fixed, paraffin-embedded specimens (FFPE) in the formalin gas-phase (FOLGAS), enabling sequential multistaining, independent from the primary and secondary antibodies and retrieval.
Sat Dec 25 00:00:00 EST 2021
Multiple Immunostainings with Different Epitope Retrievals-The FOLGAS Protocol.
International journal of molecular sciences
von Schoenfeld A,Bronsert P,Poc M,Fuller A,Filby A,Kraft S,Kurowski K,Sörensen K,Huber J,Pfeiffer J,Proietti M,Stehl V,Werner M,Seidl M
14-1079-80 was used in Immunohistochemistry to describe a sequential multistaining protocol for immunohistochemistry, immunofluorescence and CyTOF imaging for formalin-fixed, paraffin-embedded specimens (FFPE) in the formalin gas-phase (FOLGAS), enabling sequential multistaining, independent from the primary and secondary antibodies and retrieval.
Sat Dec 25 00:00:00 EST 2021
Erlotinib Promotes Ligand-Induced EGFR Degradation in 3D but Not 2D Cultures of Pancreatic Ductal Adenocarcinoma Cells.
Cancers
Betriu N,Andreeva A,Semino CE
14-1079-80 was used in Immunocytochemistry-immunofluorescence to develop a new model of epithelial growth factor receptor internalization and degradation upon erlotinib treatment in pancreatic ductal adenocarcinoma cells cultured in a 3D self-assembling peptide scaffold.
Tue Sep 07 00:00:00 EDT 2021
Erlotinib Promotes Ligand-Induced EGFR Degradation in 3D but Not 2D Cultures of Pancreatic Ductal Adenocarcinoma Cells.
Cancers
Betriu N,Andreeva A,Semino CE
14-1079-80 was used in Immunocytochemistry-immunofluorescence to develop a new model of epithelial growth factor receptor internalization and degradation upon erlotinib treatment in pancreatic ductal adenocarcinoma cells cultured in a 3D self-assembling peptide scaffold.
Tue Sep 07 00:00:00 EDT 2021
Increased LAMP2A levels correlate with a shorter disease-free survival of HER2 negative breast cancer patients and increased breast cancer cell viability.
Biochemical and biophysical research communications
Tokarchuk I,Janser FA,Schläfli AM,Pinto MT,Humbert M,Niklaus NJ,Berezowska S,Langer R,Tschan MP
14-1079-80 was used in Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to examine the expression of the CMA markers HSP8 and LAMP2A in different breast cancer cell lines.
Fri Sep 10 00:00:00 EDT 2021
Passive Diffusion vs Active pH-Dependent Encapsulation of Tyrosine Kinase Inhibitors Vandetanib and Lenvatinib into Folate-Targeted Ferritin Delivery System.
International journal of nanomedicine
Skubalova Z,Rex S,Sukupova M,Zahalka M,Skladal P,Pribyl J,Michalkova H,Weerasekera A,Adam V,Heger Z
14-1079-80 was used in Immunocytochemistry to show that since the passive loading does not require a reassembly step for which acids are needed, the presented investigation serves as a solid basis for future studies focused on encapsulation of small hydrophobic molecules.
Fri Jan 29 00:00:00 EST 2021
HLA-B*27:05 alters immunodominance hierarchy of universal influenza-specific CD8+ T cells.
PLoS pathogens
Sant S,Quiñones-Parra SM,Koutsakos M,Grant EJ,Loudovaris T,Mannering SI,Crowe J,van de Sandt CE,Rimmelzwaan GF,Rossjohn J,Gras S,Loh L,Nguyen THO,Kedzierska K
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 14-1079-80) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2020
MAVS Genetic Variation Is Associated with Decreased HIV-1 Replication In Vitro and Reduced CD4+ T Cell Infection in HIV-1-Infected Individuals.
Viruses
Stunnenberg M,van Pul L,Sprokholt JK,van Dort KA,Gringhuis SI,Geijtenbeek TBH,Kootstra NA
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 14-1079-80) in Flow Cytometry
Thu Jul 16 00:00:00 EDT 2020
PBRM1 and the glycosylphosphatidylinositol biosynthetic pathway promote tumor killing mediated by MHC-unrestricted cytotoxic lymphocytes.
Science advances
Menasche BL,Davis EM,Wang S,Ouyang Y,Li S,Yu H,Shen J
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 14-1079-80) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2020
Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity.
Cell stem cell
Li Y,Hermanson DL,Moriarity BS,Kaufman DS
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 14-1079-80) in Flow Cytometry
Thu Aug 02 00:00:00 EDT 2018
Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity.
Cell stem cell
Li Y,Hermanson DL,Moriarity BS,Kaufman DS
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 14-1079-80) in Flow Cytometry
Thu Aug 02 00:00:00 EDT 2018
TCF1 expression marks self-renewing human CD8+ T cells.
Blood advances
Kratchmarov R,Magun AM,Reiner SL
14-1079 was used in Flow cytometry/Cell sorting to show analyses of TCF1 expression from patient specimens may become a useful biomarker for adaptive immune function in response to vaccination, infection, autoimmunity, and cancer.
Tue Jul 24 00:00:00 EDT 2018
PD1 is expressed on exhausted T cells as well as virus specific memory CD8+ T cells in the bone marrow of myeloma patients.
Oncotarget
Sponaas AM,Yang R,Rustad EH,Standal T,Thoresen AS,Dao Vo C,Waage A,Slørdahl TS,Børset M,Sundan A
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 14-1079-80) in Flow Cytometry
Fri Aug 10 00:00:00 EDT 2018
Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism.
Nature communications
Arbore G,West EE,Rahman J,Le Friec G,Niyonzima N,Pirooznia M,Tunc I,Pavlidis P,Powell N,Li Y,Liu P,Servais A,Couzi L,Fremeaux-Bacchi V,Placais L,Ferraro A,Walsh PR,Kavanagh D,Afzali B,Lavender P,Lachmann HJ,Kemper C
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 14-1079-80) in Flow Cytometry
Wed Oct 10 00:00:00 EDT 2018
Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.
The Journal of clinical investigation
Kim SM,Roy SG,Chen B,Nguyen TM,McMonigle RJ,McCracken AN,Zhang Y,Kofuji S,Hou J,Selwan E,Finicle BT,Nguyen TT,Ravi A,Ramirez MU,Wiher T,Guenther GG,Kono M,Sasaki AT,Weisman LS,Potma EO,Tromberg BJ,Edwards RA,Hanessian S,Edinger AL
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 14-1079-80) in Immunofluorescence
Tue Nov 01 00:00:00 EDT 2016
Cross-reactive multifunctional CD4+ T cell responses against Salmonella enterica serovars Typhi, Paratyphi A and Paratyphi B in humans following immunization with live oral typhoid vaccine Ty21a.
Clinical immunology (Orlando, Fla.)
Wahid R,Fresnay S,Levine MM,Sztein MB
14107980 was used in flow cytometry to determine the S. Typhi, S. Paratyphi A, and S. Paratyphi B cross-reactive CD4 positive T cell responses elicited by immunization with Ty21a
Thu Dec 01 00:00:00 EST 2016
Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells.
Cell death & disease
Tan KP,Ho MY,Cho HC,Yu J,Hung JT,Yu AL
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 14-1079-80) in Immunofluorescence
Thu Aug 25 00:00:00 EDT 2016
T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma.
Oncoimmunology
Singh N,Kulikovskaya I,Barrett DM,Binder-Scholl G,Jakobsen B,Martinez D,Pawel B,June CH,Kalos MD,Grupp SA
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 14-1079-80) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Lysosomal membrane permeabilization is involved in oxidative stress-induced apoptotic cell death in LAMP2-deficient iPSCs-derived cerebral cortical neurons.
Biochemistry and biophysics reports
Law CY,Siu CW,Fan K,Lai WH,Au KW,Lau YM,Wong LY,Ho JCY,Lee YK,Tse HF,Ng KM
14-1079 was used in Western Blotting to suggest the involvement of lysosomal membrane permeabilization in the LAMP2 deficiency associated neural injury.
Tue Mar 01 00:00:00 EST 2016
A TNFRSF14-FcɛRI-mast cell pathway contributes to development of multiple features of asthma pathology in mice.
Nature communications
Sibilano R,Gaudenzio N,DeGorter MK,Reber LL,Hernandez JD,Starkl PM,Zurek OW,Tsai M,Zahner S,Montgomery SB,Roers A,Kronenberg M,Yu M,Galli SJ
14-1079 was used in Immunofluorescence to study the mechanisms by which TNFSF14 functions to promote airway remodelling in asthma.
Fri Dec 16 00:00:00 EST 2016
Functional dichotomy of Vδ2 γδ T cells in chronic hepatitis C virus infections: role in cytotoxicity but not for IFN-γ production.
Scientific reports
Yin W,Tong S,Zhang Q,Shao J,Liu Q,Peng H,Hu H,Peng M,Hu P,Ren H,Tian Z,Zhang D
14-1079 was used in Flow cytometry/Cell sorting to analyse the phenotype and function of Vδ2 T cells in HCV-infected patients compared to healthy controls.
Thu May 19 00:00:00 EDT 2016
Laparoscopic Technique for Serial Collection of Para-Colonic, Left Colic, and Inferior Mesenteric Lymph Nodes in Macaques.
PloS one
Smedley J,Macalister R,Wangari S,Gathuka M,Ahrens J,Iwayama N,May D,Bratt D,O'Connor M,Munson P,Koday M,Lifson J,Fuller DH
14-1079 was used in Flow cytometry/Cell sorting to describe a minimally invasive laparoscopic technique.
Thu Jul 13 00:00:00 EDT 2017
Munc18-2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T-Lymphocytes.
Traffic (Copenhagen, Denmark)
Dieckmann NM,Hackmann Y,Aricò M,Griffiths GM
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 14-1079-80) in Immunofluorescence
Tue Dec 01 00:00:00 EST 2015
Unexpected heterogeneity of multifunctional T cells in response to superantigen stimulation in humans.
Clinical immunology (Orlando, Fla.)
McArthur MA,Sztein MB
14-1079 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which Staphylococcal enterotoxin B and other superantigens cause toxic shock syndrome.
Fri Feb 01 00:00:00 EST 2013
Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma.
Cancer immunology, immunotherapy : CII
Phuphanich S,Wheeler CJ,Rudnick JD,Mazer M,Wang H,Nuño MA,Richardson JE,Fan X,Ji J,Chu RM,Bender JG,Hawkins ES,Patil CG,Black KL,Yu JS
14-1079 was used in Flow cytometry/Cell sorting to study how expression of four ICT-107 targeted antigens in the pre-vaccine tumors correlated with prolonged overall survival and PFS in ND-GBM patients.
Tue Jan 01 00:00:00 EST 2013
Simian immunodeficiency virus-induced changes in T cell cytokine responses in cynomolgus macaques with latent Mycobacterium tuberculosis infection are associated with timing of reactivation.
Journal of immunology (Baltimore, Md. : 1950)
Mattila JT,Diedrich CR,Lin PL,Phuah J,Flynn JL
14-1079 was used in Flow cytometry/Cell sorting to investigate alterations in multifuctional T cell responses during HIV-M. tuberculosis coinfection in an animal model.
Tue Mar 15 00:00:00 EDT 2011
Simian immunodeficiency virus-induced changes in T cell cytokine responses in cynomolgus macaques with latent Mycobacterium tuberculosis infection are associated with timing of reactivation.
Journal of immunology (Baltimore, Md. : 1950)
Mattila JT,Diedrich CR,Lin PL,Phuah J,Flynn JL
14-1079 was used in Flow cytometry/Cell sorting to investigate alterations in multifuctional T cell responses during HIV-M. tuberculosis coinfection in an animal model.
Tue Mar 15 00:00:00 EDT 2011
Lysosomal localization and mechanism of membrane penetration influence nonenveloped virus activation of the NLRP3 inflammasome.
Virology
Barlan AU,Danthi P,Wiethoff CM
14-1079 was used in Immunofluorescence to examine the extent to which inflammasome activation correlates with adenovirus colocalization with catB-enriched lysosomes.
Sun Apr 10 00:00:00 EDT 2011
Differential effects of TBC1D15 and mammalian Vps39 on Rab7 activation state, lysosomal morphology, and growth factor dependence.
The Journal of biological chemistry
Peralta ER,Martin BC,Edinger AL
14-1079 was used in Immunofluorescence to define the Rab7 GEF and GAP proteins by testing to see if TBC1D15, and mammalian Vps39 function as Rab7 GAP and GEF, respectively.
Fri May 28 00:00:00 EDT 2010
The small chemical vacuolin-1 alters the morphology of lysosomes without inhibiting Ca2+-regulated exocytosis.
EMBO reports
Huynh C,Andrews NW
Published figure using CD107a (LAMP-1) monoclonal antibody (Product # 14-1079-80) in Flow Cytometry
Thu Sep 01 00:00:00 EDT 2005
