Product References
Pyruvate dehydrogenase kinase supports macrophage NLRP3 inflammasome activation during acute inflammation.
Cell reports
Meyers AK,Wang Z,Han W,Zhao Q,Zabalawi M,Duan L,Liu J,Zhang Q,Manne RK,Lorenzo F,Quinn MA,Song Q,Fan D,Lin HK,Furdui CM,Locasale JW,McCall CE,Zhu X
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Tue Jan 31 00:00:00 EST 2023
Platelets exacerbate cardiovascular inflammation in a murine model of Kawasaki disease vasculitis.
JCI insight
Kocatürk B,Lee Y,Nosaka N,Abe M,Martinon D,Lane ME,Moreira D,Chen S,Fishbein MC,Porritt RA,Franklin BS,Noval Rivas M,Arditi M
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Mon Jul 24 00:00:00 EDT 2023
Pexidartinib synergize PD-1 antibody through inhibiting treg infiltration by reducing TAM-derived CCL22 in lung adenocarcinoma.
Frontiers in pharmacology
Zhang W,Jiang X,Zou Y,Yuan L,Wang X
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Tue Mar 28 00:00:00 EDT 2023
MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα.
Signal transduction and targeted therapy
Feng L,Li C,Zeng LW,Gao D,Sun YH,Zhong L,Lin H,Shu HB,Li S
17-1152-82 was used in Flow Cytometry to show that the plasma membrane-associated E3 ubiquitin ligase MARCH3 negatively regulates IL-3-triggered signaling.
Mon Jan 24 00:00:00 EST 2022
MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα.
Signal transduction and targeted therapy
Feng L,Li C,Zeng LW,Gao D,Sun YH,Zhong L,Lin H,Shu HB,Li S
17-1152-82 was used in Flow Cytometry to show that the plasma membrane-associated E3 ubiquitin ligase MARCH3 negatively regulates IL-3-triggered signaling.
Mon Jan 24 00:00:00 EST 2022
Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling.
The Journal of biological chemistry
Yan Q,Gao H,Yao Q,Ling K,Xiao G
17-1152-82 was used in Flow Cytometry to determine whether phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) plays a role in skeletal development and homeostasis and what the underlying mechanisms are.
Tue Mar 01 00:00:00 EST 2022
Loss of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) in mesenchymal stem cells leads to osteopenia by impairing bone remodeling.
The Journal of biological chemistry
Yan Q,Gao H,Yao Q,Ling K,Xiao G
17-1152-82 was used in Flow Cytometry to determine whether phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (Pip5k1c) plays a role in skeletal development and homeostasis and what the underlying mechanisms are.
Tue Mar 01 00:00:00 EST 2022
The cephalic phase of insulin release is modulated by IL-1β.
Cell metabolism
Wiedemann SJ,Trimigliozzi K,Dror E,Meier DT,Molina-Tijeras JA,Rachid L,Le Foll C,Magnan C,Schulze F,Stawiski M,Häuselmann SP,Méreau H,Böni-Schnetzler M,Donath MY
17-1152-82 was used in Flow cytometry/Cell sorting to describe that this incretin-like effect of IL-1β involves neuronal transmission.
Tue Jul 05 00:00:00 EDT 2022
Lysosomal acid lipase, CSF1R, and PD-L1 determine functions of CD11c+ myeloid-derived suppressor cells.
JCI insight
Zhao T,Liu S,Ding X,Johnson EM,Hanna NH,Singh K,Sen CK,Wan J,Du H,Yan C
17-1152-82 was used in Flow cytometry/Cell sorting to investigate if CD11c+ cells switched their functions to immune suppression and tumor growth stimulation through CSF1R/PD-L1 upregulation and metabolic reprogramming.
Thu Sep 08 00:00:00 EDT 2022
The microbiota regulates hematopoietic stem cell fate decisions by controlling iron availability in bone marrow.
Cell stem cell
Zhang D,Gao X,Li H,Borger DK,Wei Q,Yang E,Xu C,Pinho S,Frenette PS
17-1152-82 was used in Flow cytometry/Cell sorting to reveal an intricate interplay between the microbiota, macrophages, and iron, and their essential roles in regulating critical HSC fate decisions under stress.
Thu Feb 03 00:00:00 EST 2022
Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single-cell profiling.
The EMBO journal
Wieghofer P,Hagemeyer N,Sankowski R,Schlecht A,Staszewski O,Amann L,Gruber M,Koch J,Hausmann A,Zhang P,Boneva S,Masuda T,Hilgendorf I,Goldmann T,Böttcher C,Priller J,Rossi FM,Lange C,Prinz M
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Mon Mar 15 00:00:00 EDT 2021
Low-dose 2-deoxy glucose stabilises tolerogenic dendritic cells and generates potent in vivo immunosuppressive effects.
Cellular and molecular life sciences : CMLS
Christofi M,Le Sommer S,Mölzer C,Klaska IP,Kuffova L,Forrester JV
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Mon Mar 01 00:00:00 EST 2021
Monocyte Subsets With High Osteoclastogenic Potential and Their Epigenetic Regulation Orchestrated by IRF8.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Das A,Wang X,Kang J,Coulter A,Shetty AC,Bachu M,Brooks SR,Dell'Orso S,Foster BL,Fan X,Ozato K,Somerman MJ,Thumbigere-Math V
17-1152-82 was used in Flow Cytometry to provide novel insights into the transcription factors and active cis-regulatory elements that regulate OC differentiation.
Fri Jan 01 00:00:00 EST 2021
HOXA11 plays critical roles in disease progression and response to cytarabine in AML.
Oncology reports
Fu JF,Shih LY,Yen TH
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Thu Jul 01 00:00:00 EDT 2021
Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia.
Molecular metabolism
La Rose AM,Bazioti V,Hoogerland JA,Svendsen AF,Groenen AG,van Faassen M,Rutten MGS,Kloosterhuis NJ,Dethmers-Ausema B,Nijland JH,Mithieux G,Rajas F,Kuipers F,Lukens MV,Soehnlein O,Oosterveer MH,Westerterp M
17-1152-82 was used in Flow Cytometry to evaluate the effect of glycemic control on leukocyte levels and coagulation in glycogen storage disease type 1a.
Mon Nov 01 00:00:00 EDT 2021
Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia.
Molecular metabolism
La Rose AM,Bazioti V,Hoogerland JA,Svendsen AF,Groenen AG,van Faassen M,Rutten MGS,Kloosterhuis NJ,Dethmers-Ausema B,Nijland JH,Mithieux G,Rajas F,Kuipers F,Lukens MV,Soehnlein O,Oosterveer MH,Westerterp M
17-1152-82 was used in Flow Cytometry to evaluate the effect of glycemic control on leukocyte levels and coagulation in glycogen storage disease type 1a.
Mon Nov 01 00:00:00 EDT 2021
Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy.
Journal of neuroinflammation
Oladiran O,Shi XQ,Yang M,Fournier S,Zhang J
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Mon Mar 22 00:00:00 EDT 2021
CX3CR1 But Not CCR2 Expression Is Required for the Development of Autoimmune Peripheral Neuropathy in Mice.
Frontiers in immunology
Oladiran O,Shi XQ,Fournier S,Zhang J
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Tue Dec 21 00:00:00 EST 2021
Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics.
eLife
Serrano-Lopez J,Hegde S,Kumar S,Serrano J,Fang J,Wellendorf AM,Roche PA,Rangel Y,Carrington LJ,Geiger H,Grimes HL,Luther S,Maillard I,Sanchez-Garcia J,Starczynowski DT,Cancelas JA
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Thu Apr 08 00:00:00 EDT 2021
Assessing Lupus-Like Disease in Murine Model Systems.
Current protocols
Lee HY,Celhar T,Fairhurst AM
17-1152-82 was used in Flow Cytometry to evaluate the underlying immunological features of the disease, as a more sensitive strategy to understand the disease itself and the mechanisms of potential novel therapeutics.
Mon Nov 01 00:00:00 EDT 2021
Radiation causes tissue damage by dysregulating inflammasome-gasdermin D signaling in both host and transplanted cells.
PLoS biology
Xiao J,Wang C,Yao JC,Alippe Y,Yang T,Kress D,Sun K,Kostecki KL,Monahan JB,Veis DJ,Abu-Amer Y,Link DC,Mbalaviele G
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2020
Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model.
Glia
Boeck M,Thien A,Wolf J,Hagemeyer N,Laich Y,Yusuf D,Backofen R,Zhang P,Boneva S,Stahl A,Hilgendorf I,Agostini H,Prinz M,Wieghofer P,Schlunck G,Schlecht A,Lange C
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2020
Myeloid atg5 deletion impairs n-3 PUFA-mediated atheroprotection.
Atherosclerosis
Wang Z,Sequeira RC,Zabalawi M,Madenspacher J,Boudyguina E,Ou T,Nelson JM,Nie Y,Zhao Q,Fessler MB,Zhu X
17-1152 was used in Flow cytometry/Cell sorting to study how macrophage autophagy impacts atherosclerotic progression when comparing dietary n-3 PUFA supplementation vs. saturated fat feeding.
Sat Feb 01 00:00:00 EST 2020
Characterization and regulation of osteoclast precursors following chronic Porphyromonas gingivalis infection.
Journal of leukocyte biology
Zhao Y,Li Z,Su L,Ballesteros-Tato A,Katz J,Michalek SM,Feng X,Zhang P
17-1152-82 was used in Flow Cytometry to provide new insights into the characterization and regulation of OCP following a chronic bacterial infection.
Thu Oct 01 00:00:00 EDT 2020
MOSPD2 is a therapeutic target for the treatment of CNS inflammation.
Clinical and experimental immunology
Yacov N,Kafri P,Salem Y,Propheta-Meiran O,Feldman B,Breitbart E,Mendel I
17-1152 was used in Flow cytometry/Cell sorting to study the therapeutic potential of MOSPD2 in central nervous system disease.
Sat Aug 01 00:00:00 EDT 2020
Androgen Receptor Signaling Positively Regulates Monocytic Development.
Frontiers in immunology
Consiglio CR,Gollnick SO
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Thu Apr 29 00:00:00 EDT 2021
Distinct Transcriptional Responses across Tissue-Resident Macrophages to Short-Term and Long-Term Metabolic Challenge.
Cell reports
Brykczynska U,Geigges M,Wiedemann SJ,Dror E,Böni-Schnetzler M,Hess C,Donath MY,Paro R
17-1152 was used in Flow cytometry/Cell sorting to provide a resource for assessing the impact of nutrition and over-nutrition on the spectrum of macrophages across tissues with a potential for identification of systemic responses.
Tue Feb 04 00:00:00 EST 2020
Counter Regulation of Spic by NF-κB and STAT Signaling Controls Inflammation and Iron Metabolism in Macrophages.
Cell reports
Alam Z,Devalaraja S,Li M,To TKJ,Folkert IW,Mitchell-Velasquez E,Dang MT,Young P,Wilbur CJ,Silverman MA,Li X,Chen YH,Hernandez PT,Bhattacharyya A,Bhattacharya M,Levine MH,Haldar M
17-1152 was used in Flow cytometry/Cell sorting to uncover a pathway wherein counter-regulation of Spic by NF-κB and STATs attune inflammatory responses and iron metabolism in macrophages.
Tue Jun 30 00:00:00 EDT 2020
A Two-Cell Model for IL-1β Release Mediated by Death-Receptor Signaling.
Cell reports
Donado CA,Cao AB,Simmons DP,Croker BA,Brennan PJ,Brenner MB
17-1152 was used in Flow cytometry/Cell sorting to describe an alternative, two-cell model for IL-1β release where invariant natural killer T (iNKT) cells use the death receptor pathway to instruct antigen-presenting cells to secrete IL-1β.
Tue Apr 07 00:00:00 EDT 2020
The cis-Regulatory Atlas of the Mouse Immune System.
Cell
Yoshida H,Lareau CA,Ramirez RN,Rose SA,Maier B,Wroblewska A,Desland F,Chudnovskiy A,Mortha A,Dominguez C,Tellier J,Kim E,Dwyer D,Shinton S,Nabekura T,Qi Y,Yu B,Robinette M,Kim KW,Wagers A,Rhoads A,Nutt SL,Brown BD,Mostafavi S,Buenrostro JD,Benoist C
17-1152-82 was used in Flow Cytometry to generate matched epigenome and transcriptome measurements in 86 primary cell types that span the mouse immune system and its differentiation cascade.
Thu Feb 07 00:00:00 EST 2019
Concomitant type I IFN and M-CSF signaling reprograms monocyte differentiation and drives pro-tumoral arginase production.
EBioMedicine
Tong Y,Zhou L,Yang L,Guo P,Cao Y,Qin FX,Liu J
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Tue Jan 01 00:00:00 EST 2019
Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.
Cell stem cell
McKenzie MD,Ghisi M,Oxley EP,Ngo S,Cimmino L,Esnault C,Liu R,Salmon JM,Bell CC,Ahmed N,Erlichster M,Witkowski MT,Liu GJ,Chopin M,Dakic A,Simankowicz E,Pomilio G,Vu T,Krsmanovic P,Su S,Tian L,Baldwin TM,Zalcenstein DA,DiRago L,Wang S,Metcalf D,Johnstone RW,Croker BA,Lancaster GI,Murphy AJ,Naik SH,Nutt SL,Pospisil V,Schroeder T,Wall M,Dawson MA,Wei AH,de Thé H,Ritchie ME,Zuber J,Dickins RA
17-1152 was used in Flow cytometry/Cell sorting to investigate cancer stem cell plasticity in acute myeloid leukemia.
Thu Aug 01 00:00:00 EDT 2019
Myeloid Folliculin balances mTOR activation to maintain innate immunity homeostasis.
JCI insight
Li J,Wada S,Weaver LK,Biswas C,Behrens EM,Arany Z
17-1152 was used in Flow cytometry/Cell sorting to investigate the effects of LPS on the tumour suppressor folliculin.
Thu Mar 07 00:00:00 EST 2019
Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells.
Frontiers in immunology
Zwick M,Ulas T,Cho YL,Ried C,Grosse L,Simon C,Bernhard C,Busch DH,Schultze JL,Buchholz VR,Stutte S,Brocker T
17-1152-82 was used in Flow Cytometry to suggest that Ppef2 is crucial to support survival of immature CD8+ DCs, while Ppef2 down-regulation during DC-maturation limits T cell responses.
Tue Oct 27 00:00:00 EDT 2020
c-Myb Exacerbates Atherosclerosis through Regulation of Protective IgM-Producing Antibody-Secreting Cells.
Cell reports
Shikatani EA,Besla R,Ensan S,Upadhye A,Khyzha N,Li A,Emoto T,Chiu F,Degousee N,Moreau JM,Perry HM,Thayaparan D,Cheng HS,Pacheco S,Smyth D,Noyan H,Zavitz CCJ,Bauer CMT,Hilgendorf I,Libby P,Swirski FK,Gommerman JL,Fish JE,Stampfli MR,Cybulsky MI,Rubin BB,Paige CJ,Bender TP,McNamara CA,Husain M,Robbins CS
17-1152-82 was used in Flow Cytometry to identify the nuclear transcription factor c-Myb as an important mediator of atherosclerotic disease in mice.
Tue May 21 00:00:00 EDT 2019
Bone loss in C57BL/6J-OlaHsd mice, a substrain of C57BL/6J carrying mutated alpha-synuclein and multimerin-1 genes.
Journal of cellular physiology
Liron T,Raphael B,Hiram-Bab S,Bab IA,Gabet Y
17-1152 was used in Flow cytometry/Cell sorting to elucidate unexplained differences in murine basal bone measurements between different research centres and the importance of specifying the exact substrain type.
Mon Jan 01 00:00:00 EST 2018
Captopril mitigates splenomegaly and myelofibrosis in the Gata1low murine model of myelofibrosis.
Journal of cellular and molecular medicine
Corey SJ,Jha J,McCart EA,Rittase WB,George J,Mattapallil JJ,Mehta H,Ognoon M,Bylicky MA,Summers TA,Day RM
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor 1 Shed by ADAM17 Drives Mouse Macrophage Proliferation in Acute and Chronic Inflammation.
Molecular and cellular biology
Tang J,Frey JM,Wilson CL,Moncada-Pazos A,Levet C,Freeman M,Rosenfeld ME,Stanley ER,Raines EW,Bornfeldt KE
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
Advanced Glycation End Products Enhance Murine Monocyte Proliferation in Bone Marrow and Prime Them into an Inflammatory Phenotype through MAPK Signaling.
Journal of diabetes research
Jin X,Liu L,Zhang Y,Xiang Y,Yin G,Lu Y,Shi L,Dong J,Shen C
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Wed Oct 10 00:00:00 EDT 2018
GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function.
Frontiers in immunology
Sun L,Rautela J,Delconte RB,Souza-Fonseca-Guimaraes F,Carrington EM,Schenk RL,Herold MJ,Huntington ND,Lew AM,Xu Y,Zhan Y
17-1152 was used in Flow cytometry/Cell sorting to study whether the dosage of GM-CSF regulates the development of three types of myeloid cells from cultured bone marrow cells.
Fri Sep 20 00:00:00 EDT 2019
Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy.
Scientific reports
Katschke KJ,Xi H,Cox C,Truong T,Malato Y,Lee WP,McKenzie B,Arceo R,Tao J,Rangell L,Reichelt M,Diehl L,Elstrott J,Weimer RM,van Lookeren Campagne M
17-1152 was used in Flow cytometry to demonstrate that complement is activated on photoreceptor outer segments in the retina peripheral to atrophic lesions associated with geographic autotrophy.
Wed May 09 00:00:00 EDT 2018
Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes.
Nature communications
Westhorpe CLV,Norman MU,Hall P,Snelgrove SL,Finsterbusch M,Li A,Lo C,Tan ZH,Li S,Nilsson SK,Kitching AR,Hickey MJ
17-1152 was used in Flow cytometry/Cell sorting to determine how effector CD4+ T cells respond to intravascular antigens.
Wed Feb 21 00:00:00 EST 2018
Diabetes impairs wound healing by Dnmt1-dependent dysregulation of hematopoietic stem cells differentiation towards macrophages.
Nature communications
Yan J,Tie G,Wang S,Tutto A,DeMarco N,Khair L,Fazzio TG,Messina LM
17-1152 was used in Flow cytometry/Cell sorting to demonstrate for the first time that type 2 diabetes mellitus induces an haematopoietic stem cell-autonomous mechanism that causes impaired wound healing.
Tue Jan 02 00:00:00 EST 2018
Aryl Hydrocarbon Receptor Controls Monocyte Differentiation into Dendritic Cells versus Macrophages.
Immunity
Goudot C,Coillard A,Villani AC,Gueguen P,Cros A,Sarkizova S,Tang-Huau TL,Bohec M,Baulande S,Hacohen N,Amigorena S,Segura E
Tue Sep 19 00:00:00 EDT 2017
Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (≥C20)-acyl chains in macrophages.
Journal of lipid research
Wall VZ,Barnhart S,Kramer F,Kanter JE,Vivekanandan-Giri A,Pennathur S,Bolego C,Ellis JM,Gijón MA,Wolfgang MJ,Bornfeldt KE
17-1152 was used in Flow cytometry/Cell sorting to investigate the downstream effects of lipopolysaccharide-induced induction of acyl-CoA thioesterase 7, and its role in inflammatory settings in myeloid cells.
Thu Jun 01 00:00:00 EDT 2017
Erythropoietin enhances Kupffer cell number and activity in the challenged liver.
Scientific reports
Gilboa D,Haim-Ohana Y,Deshet-Unger N,Ben-Califa N,Hiram-Bab S,Reuveni D,Zigmond E,Gassmann M,Gabet Y,Varol C,Neumann D
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Mon Sep 04 00:00:00 EDT 2017
Erythropoietin enhances Kupffer cell number and activity in the challenged liver.
Scientific reports
Gilboa D,Haim-Ohana Y,Deshet-Unger N,Ben-Califa N,Hiram-Bab S,Reuveni D,Zigmond E,Gassmann M,Gabet Y,Varol C,Neumann D
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Mon Sep 04 00:00:00 EDT 2017
TLR2-/- Mice Display Increased Clearance of Dermatophyte Trichophyton mentagrophytes in the Setting of Hyperglycemia.
Frontiers in cellular and infection microbiology
Almeida DF,Fraga-Silva TF,Santos AR,Finato AC,Marchetti CM,Golim MA,Lara VS,Arruda MS,Venturini J
17-1152 was used in Flow cytometry/Cell sorting to demonstrate that TLR2 diminishes the development of adaptive immune responses during experimental deep dermatophytosis and, in a diabetic scenario, acts to intensify a non-protective inflammatory response.
Mon Sep 18 00:00:00 EDT 2017
Longitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature.
Nature communications
Reismann D,Stefanowski J,Günther R,Rakhymzhan A,Matthys R,Nützi R,Zehentmeier S,Schmidt-Bleek K,Petkau G,Chang HD,Naundorf S,Winter Y,Melchers F,Duda G,Hauser AE,Niesner RA
17-1152 was used in Flow cytometry/Cell sorting to develop longitudinal intravital imaging of the bone marrow to analyse cellular dynamics within the deep marrow.
Mon Dec 18 00:00:00 EST 2017
Hepatic JAK2 protects against atherosclerosis through circulating IGF-1.
JCI insight
Sivasubramaniyam T,Schroer SA,Li A,Luk CT,Shi SY,Besla R,Dodington DW,Metherel AH,Kitson AP,Brunt JJ,Lopes J,Wagner KU,Bazinet RP,Bendeck MP,Robbins CS,Woo M
17-1152 was used in Flow cytometry/Cell sorting to determine the role of hepatic Jak2 in atherosclerosis.
Thu Jul 20 00:00:00 EDT 2017
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
The Journal of clinical investigation
Cole CB,Verdoni AM,Ketkar S,Leight ER,Russler-Germain DA,Lamprecht TL,Demeter RT,Magrini V,Ley TJ
17-1152 was used in Flow cytometry/Cell sorting to suggest that PML-RARA requires DNMT3A to initiate acute promyelocytic leukemia in mice.
Fri Jan 01 00:00:00 EST 2016
IL-33 amplifies an innate immune response in the degenerating retina.
The Journal of experimental medicine
Xi H,Katschke KJ,Li Y,Truong T,Lee WP,Diehl L,Rangell L,Tao J,Arceo R,Eastham-Anderson J,Hackney JA,Iglesias A,Cote-Sierra J,Elstrott J,Weimer RM,van Lookeren Campagne M
17-1152 was used in Flow cytometry/Cell sorting to demonstrate a central role for IL-33 in regulating mononuclear phagocyte recruitment to the photoreceptor layer and position IL-33 signaling as a potential therapeutic target in macular degenerative diseases.
Mon Feb 08 00:00:00 EST 2016
Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1.
Arteriosclerosis, thrombosis, and vascular biology
Herbin O,Regelmann AG,Ramkhelawon B,Weinstein EG,Moore KJ,Alexandropoulos K
17-1152 was used in Flow cytometry/Cell sorting to analyse the role of Chat-H in atherosclerosis development, showing that monocyte adhesion and plaque recruitment is regulated by Chat-H/SHEP1.
Thu Sep 01 00:00:00 EDT 2016
Platelets Guide Leukocytes to Their Sites of Extravasation.
PLoS biology
Zuchtriegel G,Uhl B,Puhr-Westerheide D,Pörnbacher M,Lauber K,Krombach F,Reichel CA
17-1152 was used in Flow cytometry/Cell sorting to uncover a platelet-directed, spatiotemporally organised, multicellular crosstalk that is essential for effective trafficking of leukocytes to the site of inflammation.
Sun May 01 00:00:00 EDT 2016
CX3CR1 deficiency delays acute skeletal muscle injury repair by impairing macrophage functions.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhao W,Lu H,Wang X,Ransohoff RM,Zhou L
17-1152 was used in Flow cytometry/Cell sorting to study the role of CX3CR1 in regulating intramuscular macrophage number and function in acute injury repair.
Fri Jan 01 00:00:00 EST 2016
Enforced Expression of Hoxa3 Inhibits Classical and Promotes Alternative Activation of Macrophages In Vitro and In Vivo.
Journal of immunology (Baltimore, Md. : 1950)
Al Sadoun H,Burgess M,Hentges KE,Mace KA
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
PER1 prevents excessive innate immune response during endotoxin-induced liver injury through regulation of macrophage recruitment in mice.
Cell death & disease
Wang T,Wang Z,Yang P,Xia L,Zhou M,Wang S,Du J,Zhang J
17-1152 was used in Flow cytometry/Cell sorting to reveal that Per1 interaction with PPAR-γ prevents an excessive innate immune response in endotoxin-induced liver injury.
Thu Apr 07 00:00:00 EDT 2016
Intravaginal Chlamydia trachomatis Challenge Infection Elicits TH1 and TH17 Immune Responses in Mice That Promote Pathogen Clearance and Genital Tract Damage.
PloS one
Vicetti Miguel RD,Quispe Calla NE,Pavelko SD,Cherpes TL
17-1152 was used in Flow cytometry/Cell sorting to determine if intravaginal infection with occulogenital Chlamydia trachomatis is a possible mouse model for Chlamydia infection in humans.
Fri Aug 04 00:00:00 EDT 2017
Perivascular Mast Cells Govern Shear Stress-Induced Arteriogenesis by Orchestrating Leukocyte Function.
Cell reports
Chillo O,Kleinert EC,Lautz T,Lasch M,Pagel JI,Heun Y,Troidl K,Fischer S,Caballero-Martinez A,Mauer A,Kurz ARM,Assmann G,Rehberg M,Kanse SM,Nieswandt B,Walzog B,Reichel CA,Mannell H,Preissner KT,Deindl E
17-1152 was used in Flow cytometry/Cell sorting to find that perivascular mast cells are central regulators of shear stress-induced arteriogenesis by orchestrating leukocyte function and growth factor/cytokine release.
Tue Aug 23 00:00:00 EDT 2016
Both Cerebral and Hematopoietic Deficiencies in CCR2 Result in Uncontrolled Herpes Simplex Virus Infection of the Central Nervous System in Mice.
PloS one
Menasria R,Canivet C,Piret J,Gosselin J,Boivin G
17-1152 was used in Flow cytometry/Cell sorting to study how CCR2 expressed on cells of the CNS is important for the control of HSV-1 replication and the inflammatory environment during experimental encephalitis.
Tue Jul 18 00:00:00 EDT 2017
Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.
Nature neuroscience
Haines JD,Herbin O,de la Hera B,Vidaurre OG,Moy GA,Sun Q,Fung HY,Albrecht S,Alexandropoulos K,McCauley D,Chook YM,Kuhlmann T,Kidd GJ,Shacham S,Casaccia P
17-1152 was used in Flow cytometry/Cell sorting to reveal that CRM1 inhibitors have the ability to modulate the export of molecules associated with both axonal damage and also neuroprotection.
Wed Apr 01 00:00:00 EDT 2015
Deficiency in lymphotoxin β receptor protects from atherosclerosis in apoE-deficient mice.
Circulation research
Grandoch M,Feldmann K,Göthert JR,Dick LS,Homann S,Klatt C,Bayer JK,Waldheim JN,Rabausch B,Nagy N,Oberhuber A,Deenen R,Köhrer K,Lehr S,Homey B,Pfeffer K,Fischer JW
17-1152 was used in Flow cytometry/Cell sorting to elucidate the role of lymphotoxin Β receptor in atherosclerosis.
Fri Apr 10 00:00:00 EDT 2015
Inefficient clearance of myelin debris by microglia impairs remyelinating processes.
The Journal of experimental medicine
Lampron A,Larochelle A,Laflamme N,Préfontaine P,Plante MM,Sánchez MG,Yong VW,Stys PK,Tremblay MÈ,Rivest S
17-1152 was used in Flow cytometry/Cell sorting to investigate how there may be no efficient remyelination after a primary demyelinating insult, if myelin clearance by microglia is impaired.
Mon Apr 06 00:00:00 EDT 2015
Low-dose TNF augments fracture healing in normal and osteoporotic bone by up-regulating the innate immune response.
EMBO molecular medicine
Chan JK,Glass GE,Ersek A,Freidin A,Williams GA,Gowers K,Espirito Santo AI,Jeffery R,Otto WR,Poulsom R,Feldmann M,Rankin SM,Horwood NJ,Nanchahal J
17-1152 was used in Flow cytometry/Cell sorting to investigate the optimal treatment course of low-dose recombinant human TNF to augment bone fracture repair in a mouse model, and the major cells involved.
Fri May 01 00:00:00 EDT 2015
Spatiotemporal expression dynamics of selectins govern the sequential extravasation of neutrophils and monocytes in the acute inflammatory response.
Arteriosclerosis, thrombosis, and vascular biology
Zuchtriegel G,Uhl B,Hessenauer ME,Kurz AR,Rehberg M,Lauber K,Krombach F,Reichel CA
17-1152 was used in Flow cytometry/Cell sorting to provide novel insights into the mechanisms initiating the sequential infiltration of the perivascular tissue by neutrophils and monocytes in the acute inflammatory response.
Wed Apr 01 00:00:00 EDT 2015
The late endosomal adaptor molecule p14 (LAMTOR2) regulates TGFβ1-mediated homeostasis of Langerhans cells.
The Journal of investigative dermatology
Sparber F,Tripp CH,Komenda K,Scheffler JM,Clausen BE,Huber LA,Romani N,Stoitzner P
17-1152 was used in Flow cytometry/Cell sorting to study regulation of TGFβ1-mediated homeostasis of Langerhans cells by the late endosomal adaptor molecule p14 (LAMTOR2).
Thu Jan 01 00:00:00 EST 2015
Myeloid Cell-Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Knuever J,Willenborg S,Ding X,Akyüz MD,Partridge L,Niessen CM,Brüning JC,Eming SA
17-1152 was used in Flow cytometry/Cell sorting to provide evidence for a proinflammatory IR/IGF-1R-dependent pathway in myeloid cells which may be useful in the treatment against DM.
Tue Dec 01 00:00:00 EST 2015
Infiltration Pattern of Blood Monocytes into the Central Nervous System during Experimental Herpes Simplex Virus Encephalitis.
PloS one
Menasria R,Canivet C,Piret J,Boivin G
17-1152 was used in Flow cytometry/Cell sorting to suggest that blood monocyte-derived macrophages infiltrate the CNS and may contribute, with resident microglia, to the innate immune response seen during experimental HSE.
Wed Aug 17 00:00:00 EDT 2016
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
Nature immunology
Agudo J,Ruzo A,Tung N,Salmon H,Leboeuf M,Hashimoto D,Becker C,Garrett-Sinha LA,Baccarini A,Merad M,Brown BD
17-1152 was used in Flow cytometry/Cell sorting to identify the miR-126-VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs.
Wed Jan 01 00:00:00 EST 2014
Endothelial C-type natriuretic peptide maintains vascular homeostasis.
The Journal of clinical investigation
Moyes AJ,Khambata RS,Villar I,Bubb KJ,Baliga RS,Lumsden NG,Xiao F,Gane PJ,Rebstock AS,Worthington RJ,Simone MI,Mota F,Rivilla F,Vallejo S,Peiró C,Sánchez Ferrer CF,Djordjevic S,Caulfield MJ,MacAllister RJ,Selwood DL,Ahluwalia A,Hobbs AJ
17-1152 was used in Flow cytometry/Cell sorting to evaluate mice with endothelial-specific deletion of C-type natriuretic peptide (CNP), showing that it is essential for multiple aspects of vascular regulation.
Mon Sep 01 00:00:00 EDT 2014
The promotion of breast cancer metastasis caused by inhibition of CSF-1R/CSF-1 signaling is blocked by targeting the G-CSF receptor.
Cancer immunology research
Swierczak A,Cook AD,Lenzo JC,Restall CM,Doherty JP,Anderson RL,Hamilton JA
17-1152 was used in Neutralization experiments to investigate the effect of blocking CSF-1R/CSF-1 signalling in breast cancer.
Fri Aug 01 00:00:00 EDT 2014
Protective role for Toll-like receptor-9 in the development of atherosclerosis in apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology
Koulis C,Chen YC,Hausding C,Ahrens I,Kyaw TS,Tay C,Allen T,Jandeleit-Dahm K,Sweet MJ,Akira S,Bobik A,Peter K,Agrotis A
17-1152 was used in Flow cytometry/Cell sorting to investigate whether TLR9 has a role in the development of atherosclerosis in apolipoprotein E-deficient mice.
Sat Mar 01 00:00:00 EST 2014
Atorvastatin improves plaque stability in ApoE-knockout mice by regulating chemokines and chemokine receptors.
PloS one
Nie P,Li D,Hu L,Jin S,Yu Y,Cai Z,Shao Q,Shen J,Yi J,Xiao H,Shen L,He B
17-1152 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms of the protective effect of statins against atherosclerosis.
Thu Jan 22 00:00:00 EST 2015
STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13.
Nature communications
Zhang H,Hu H,Greeley N,Jin J,Matthews AJ,Ohashi E,Caetano MS,Li HS,Wu X,Mandal PK,McMurray JS,Moghaddam SJ,Sun SC,Watowich SS
17-1152 was used in Flow cytometry/Cell sorting to investigate the mechanism by which STAT3 curbs pro-inflammatory cytokine production mediated by NF-κB signalling, showing that it restrains signalling by suppressing expression of Ubc13.
Mon Dec 15 00:00:00 EST 2014
Local proliferation dominates lesional macrophage accumulation in atherosclerosis.
Nature medicine
Robbins CS,Hilgendorf I,Weber GF,Theurl I,Iwamoto Y,Figueiredo JL,Gorbatov R,Sukhova GK,Gerhardt LM,Smyth D,Zavitz CC,Shikatani EA,Parsons M,van Rooijen N,Lin HY,Husain M,Libby P,Nahrendorf M,Weissleder R,Swirski FK
17-1152 was used in Flow cytometry/Cell sorting to study the underlying molecular mechanisms of macrophage accumulation in atherosclerosis.
Sun Sep 01 00:00:00 EDT 2013
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
Nature cell biology
Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors.
The Journal of experimental medicine
Chen YL,Chen TT,Pai LM,Wesoly J,Bluyssen HA,Lee CK
17-1152 was used in Flow cytometry/Cell sorting to define a critical role for the FL/IFN-I/Flt3 axis in plasmacytoid dendritic cell differentiation from common lymphoid progenitors.
Mon Nov 18 00:00:00 EST 2013
Resolvin E1 regulates osteoclast fusion via DC-STAMP and NFATc1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhu M,Van Dyke TE,Gyurko R
17-1152 was used in Flow cytometry/Cell sorting to evaluate the contribution of the proresolution mediator resolvin E1 (RvE1) on the resolution phase during inflammatory bone disease.
Thu Aug 01 00:00:00 EDT 2013
Amelioration of experimental autoimmune encephalomyelitis by the quinoline-3-carboxamide paquinimod: reduced priming of proinflammatory effector CD4(+) T cells.
The American journal of pathology
Helmersson S,Sundstedt A,Deronic A,Leanderson T,Ivars F
17-1152 was used in Flow cytometry/Cell sorting to show that paquinimod treatment during the first 5 days after induction of experimental autoimmune encephalomyelitis eases disease symptoms.
Wed May 01 00:00:00 EDT 2013
Recipient myeloid-derived immunomodulatory cells induce PD-1 ligand-dependent donor CD4+Foxp3+ regulatory T cell proliferation and donor-recipient immune tolerance after murine nonmyeloablative bone marrow transplantation.
Journal of immunology (Baltimore, Md. : 1950)
van der Merwe M,Abdelsamed HA,Seth A,Ong T,Vogel P,Pillai AB
17-1152 was used in Flow cytometry/Cell sorting to investigate the specific mechanisms of immune tolerance following TLI/ATS conditioning, showing the induction of PD-1 ligand-dependent donor Treg proliferation and donor-recipient immune tolerance.
Sun Dec 01 00:00:00 EST 2013
Inflammation and resolution are associated with upregulation of fatty acid β-oxidation in Zymosan-induced peritonitis.
PloS one
Fujieda Y,Manno A,Hayashi Y,Rhodes N,Guo L,Arita M,Bamba T,Fukusaki E
17-1152 was used in Flow cytometry/Cell sorting to study how the resolution of inflammation, and inflammation itself, may be associated with the upregulation of fatty acid β-oxidation in Zymosan-induced peritonitis.
Thu Jan 16 00:00:00 EST 2014
The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function.
American journal of clinical and experimental immunology
Noonan T,Lukas S,Peet GW,Pelletier J,Panzenbeck M,Hanidu A,Mazurek S,Wasti R,Rybina I,Roma T,Kronkaitis A,Shoultz A,Souza D,Jiang H,Nabozny G,Modis LK
17-1152 was used in Flow cytometry/Cell sorting to assess the relative contribution of the features of vascular adhesion protein-1 to its function.
Thu Jul 25 00:00:00 EDT 2013
N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells.
Blood
Greenbaum AM,Revollo LD,Woloszynek JR,Civitelli R,Link DC
17-1152 was used in Flow cytometry/Cell sorting to investigate whether N-cadherin expression on osteoblast lineage cells regulates HSC function and quiescence, showing that it is not required.
Thu Jul 12 00:00:00 EDT 2012
Mechanisms of indirect acute lung injury: a novel role for the coinhibitory receptor, programmed death-1.
Annals of surgery
Monaghan SF,Thakkar RK,Heffernan DS,Huang X,Chung CS,Lomas-Neira J,Cioffi WG,Ayala A
17-1152 was used in Flow cytometry/Cell sorting to investigate how PD-1 expression contributes to mortality after the induction of indirect-acute lung injury.
Sun Jan 01 00:00:00 EST 2012
In vivo inhibition of c-MYC in myeloid cells impairs tumor-associated macrophage maturation and pro-tumoral activities.
PloS one
Pello OM,Chèvre R,Laoui D,De Juan A,Lolo F,Andrés-Manzano MJ,Serrano M,Van Ginderachter JA,Andrés V
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Mon Feb 25 00:00:00 EST 2013
Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice.
The Journal of experimental medicine
Christopher MJ,Rao M,Liu F,Woloszynek JR,Link DC
17-1152 was used in Flow cytometry/Cell sorting to suggest a model in which G-CSFR signals in bone marrow monocytic cells inhibit the production of trophic factors required for osteoblast lineage cell maintenance.
Mon Feb 14 00:00:00 EST 2011
Activating transcription factor 4 regulates osteoclast differentiation in mice.
The Journal of clinical investigation
Cao H,Yu S,Yao Z,Galson DL,Jiang Y,Zhang X,Fan J,Lu B,Guan Y,Luo M,Lai Y,Zhu Y,Kurihara N,Patrene K,Roodman GD,Xiao G
17-1152 was used in Flow cytometry/Cell sorting to illustrate the potential of ATF4 as a therapeutic target for treating bone diseases associated with increased OCL activity.
Sun Aug 01 00:00:00 EDT 2010
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells.
The Journal of experimental medicine
Edelson BT,KC W,Juang R,Kohyama M,Benoit LA,Klekotka PA,Moon C,Albring JC,Ise W,Michael DG,Bhattacharya D,Stappenbeck TS,Holtzman MJ,Sung SS,Murphy TL,Hildner K,Murphy KM
17-1152 was used in Flow cytometry/Cell sorting to study the relationship between nonlymphoid CD103-expressing dendritic cells (DCs) and other DC subsets.
Mon Apr 12 00:00:00 EDT 2010
Regulation of granulocyte and macrophage populations of murine bone marrow cells by G-CSF and CD137 protein.
PloS one
Jiang D,Schwarz H
17-1152 was used in Flow cytometry/Cell sorting to confirm the role of CD137 ligand signalling in regulating myelopoiesis, and demonstrate that this growth promoting influence is restricted to the monocytic lineage.
Mon Dec 13 00:00:00 EST 2010
Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis.
The Journal of biological chemistry
Chen Y,Wang X,Di L,Fu G,Chen Y,Bai L,Liu J,Feng X,McDonald JM,Michalek S,He Y,Yu M,Fu YX,Wen R,Wu H,Wang D
Published figure using CD115 (c-fms) monoclonal antibody (Product # 17-1152-82) in Flow Cytometry
Fri Oct 24 00:00:00 EDT 2008
-Flow-20170216130641.jpg?time=20240507 "CD115 (c-fms) Antibody in Flow Cytometry (Flow)")
-Flow-20170216130641.jpg?time=20240507)
-Flow-20170216130641.jpg?time=20240507?time=20240507 "CD115 (c-fms) Antibody (17-1152-82) in Flow")
