Invitrogen

CD3 Monoclonal Antibody (UCHT1), FITC, eBioscience™

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

38 Published Figures

49 References

View all (504) CD3 antibodies

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CD3 Antibody (11-0038-80) in Flow

Staining of human peripheral blood mononuclear cells with CD45 Pacific Blue, CD19 APC and CD3 FITC. As expected based on known relative expression patterns, CD3 clone UCHT1 stains a subset of lymphocytes (pink), but not monocytes (orange) and granulocytes (blue).

CD3 Antibody in Immunocytochemistry (ICC/IF)

CD3 Antibody in Immunohistochemistry (IHC)

Product Image Gallery

CD3 Antibody — Staining of human peripheral blood cells. As expected based on known relative expression patterns, CD3 clone UCHT1 stains a subset of lymphocytes (T cells) and does not stain monocytes and granulocytes. Details: Normal human whole blood was surface stained with CD3 (clone UCHT1). After staining, red blood cells were lysed using 1-step Fix/Lyse Buffer. Cells in the lymphocyte (purple histogram), monocyte (orange histogram), or granulocyte (blue histogram) gates were used for analysis. {RE}

Product Details

11-0038-80

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

1 µg/test

View 44 publications 44 publications

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1, kappa

Recommended Isotype Control

Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

UCHT1

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_657734

Product Specific Information

Description: The UCHT1 monoclonal antibody reacts with human CD3e, a 20 kDa subunit of the TCR complex. Along with the other CD3 subunits gamma and delta, the epsilon chain is required for proper assembly, trafficking and surface expression of the TCR complex. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells. Crosslinking of TCR via immobilized UCHT1 initiates an intracellular biochemical pathway resulting in cellular activation and proliferation.

Applications Reported: The UCHT1 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This UCHT1 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

IL-36 cytokines imprint a colitogenic phenotype on CD4⁺ T helper cells.

Mucosal immunology

Leon G,Hernandez Santana YE,Irwin N,Giannoudaki E,O'Neill S,Csizmadia I,Gogarty M,Lee TJ,Ruane D,Long A,Fallon PG,Hussey S,Walsh PT

11-0038-80 was used in Immunohistochemistry to reveal an important role for IL-36 cytokines in driving the colitogenic potential of CD4+ T cells and identify a new mechanism through which they may contribute to disease pathogenesis.

Tue Mar 01 00:00:00 EST 2022

Aberrant gut-microbiota-immune-brain axis development in premature neonates with brain damage.

Cell host & microbe

Seki D,Mayer M,Hausmann B,Pjevac P,Giordano V,Goeral K,Unterasinger L,Klebermaß-Schrehof K,De Paepe K,Van de Wiele T,Spittler A,Kasprian G,Warth B,Berger A,Berry D,Wisgrill L

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Wed Oct 13 00:00:00 EDT 2021

Single-cell RNA sequencing reveals ex vivo signatures of SARS-CoV-2-reactive T cells through 'reverse phenotyping'.

Nature communications

Fischer DS,Ansari M,Wagner KI,Jarosch S,Huang Y,Mayr CH,Strunz M,Lang NJ,D'Ippolito E,Hammel M,Mateyka L,Weber S,Wolff LS,Witter K,Fernandez IE,Leuschner G,Milger K,Frankenberger M,Nowak L,Heinig-Menhard K,Koch I,Stoleriu MG,Hilgendorff A,Behr J,Pichlmair A,Schubert B,Theis FJ,Busch DH,Schiller HB,Schober K

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Mon Jul 26 00:00:00 EDT 2021

Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma.

Cell research

Chen YP,Yin JH,Li WF,Li HJ,Chen DP,Zhang CJ,Lv JW,Wang YQ,Li XM,Li JY,Zhang PP,Li YQ,He QM,Yang XJ,Lei Y,Tang LL,Zhou GQ,Mao YP,Wei C,Xiong KX,Zhang HB,Zhu SD,Hou Y,Sun Y,Dean M,Amit I,Wu K,Kuang DM,Li GB,Liu N,Ma J

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Sun Nov 01 00:00:00 EDT 2020

Aging affects responsiveness of peripheral blood mononuclear cells to immunosuppression of periodontal ligament stem cells.

The Journal of international medical research

Li X,Zhang B,Wang H,Zhao X,Zhang Z,Ding G,Wei F

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2020

Involvement of natural killer cells in the pathogenesis of endometriosis in patients with pelvic pain.

The Journal of international medical research

He J,Xu Y,Yi M,Gu C,Zhu Y,Hu G

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2020

Dendritic Cell Maturation Regulates TSPAN7 Function in HIV-1 Transfer to CD4⁺ T Lymphocytes.

Frontiers in cellular and infection microbiology

Perot BP,García-Paredes V,Luka M,Ménager MM

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Wed Mar 17 00:00:00 EDT 2021

Th2-like T Follicular Helper Cells Promote Functional Antibody Production during Plasmodium falciparum Infection.

Cell reports. Medicine

Chan JA,Loughland JR,de Labastida Rivera F,SheelaNair A,Andrew DW,Dooley NL,Wines BD,Amante FH,Webb L,Hogarth PM,McCarthy JS,Beeson JG,Engwerda CR,Boyle MJ

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Tue Dec 22 00:00:00 EST 2020

Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity.

The Journal of clinical investigation

Randzavola LO,Strege K,Juzans M,Asano Y,Stinchcombe JC,Gawden-Bone CM,Seaman MN,Kuijpers TW,Griffiths GM

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Mon Dec 02 00:00:00 EST 2019

Skewed T cell responses to Epstein-Barr virus in long-term asymptomatic kidney transplant recipients.

PloS one

Nakid-Cordero C,Arzouk N,Gauthier N,Tarantino N,Larsen M,Choquet S,Burrel S,Autran B,Vieillard V,Guihot A

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Mon Mar 30 00:00:00 EDT 2020

Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy.

Nature communications

Shi L,Wang J,Ding N,Zhang Y,Zhu Y,Dong S,Wang X,Peng C,Zhou C,Zhou L,Li X,Shi H,Wu W,Long X,Wu C,Liao W

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Thu Nov 28 00:00:00 EST 2019

Biallelic mutations in DNA ligase 1 underlie a spectrum of immune deficiencies.

The Journal of clinical investigation

Maffucci P,Chavez J,Jurkiw TJ,O'Brien PJ,Abbott JK,Reynolds PR,Worth A,Notarangelo LD,Felgentreff K,Cortes P,Boisson B,Radigan L,Cobat A,Dinakar C,Ehlayel M,Ben-Omran T,Gelfand EW,Casanova JL,Cunningham-Rundles C

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Mon Dec 03 00:00:00 EST 2018

Blocking the recruitment of naive CD4⁺ T cells reverses immunosuppression in breast cancer.

Cell research

Su S,Liao J,Liu J,Huang D,He C,Chen F,Yang L,Wu W,Chen J,Lin L,Zeng Y,Ouyang N,Cui X,Yao H,Su F,Huang JD,Lieberman J,Liu Q,Song E

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

Follicular Regulatory T Cells Are Highly Permissive to R5-Tropic HIV-1.

Journal of virology

Miller SM,Miles B,Guo K,Folkvord J,Meditz AL,McCarter MD,Levy DN,MaWhinney S,Santiago ML,Connick E

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Fri Sep 01 00:00:00 EDT 2017

Antigen receptor-redirected T cells derived from hematopoietic precursor cells lack expression of the endogenous TCR/CD3 receptor and exhibit specific antitumor capacities.

Oncoimmunology

Van Caeneghem Y,De Munter S,Tieppo P,Goetgeluk G,Weening K,Verstichel G,Bonte S,Taghon T,Leclercq G,Kerre T,Debets R,Vermijlen D,Abken H,Vandekerckhove B

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes.

Science signaling

So L,Lee J,Palafox M,Mallya S,Woxland CG,Arguello M,Truitt ML,Sonenberg N,Ruggero D,Fruman DA

11-0038 was used in Flow cytometry/Cell sorting to investigate how rapamycin can lead to selective immunosupression of lymphocytes, showing that the 4E-BP-efF4E axis aids in lymphocyte growth and proliferation.

Tue May 31 00:00:00 EDT 2016

Interaction among activated lymphocytes and mesenchymal cells through podoplanin is critical for a high IL-17 secretion.

Arthritis research & therapy

Noack M,Ndongo-Thiam N,Miossec P

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Thu Jun 23 00:00:00 EDT 2016

MAIT cells are activated during human viral infections.

Nature communications

van Wilgenburg B,Scherwitzl I,Hutchinson EC,Leng T,Kurioka A,Kulicke C,de Lara C,Cole S,Vasanawathana S,Limpitikul W,Malasit P,Young D,Denney L,Moore MD,Fabris P,Giordani MT,Oo YH,Laidlaw SM,Dustin LB,Ho LP,Thompson FM,Ramamurthy N,Mongkolsapaya J,Willberg CB,Screaton GR,Klenerman P

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Thu Jun 23 00:00:00 EDT 2016

Dendritic cell-activated cytokine-induced killer cell-mediated immunotherapy is safe and effective for cancer patients >65 years old.

Oncology letters

Liu Y,Liu H,Liu H,He P,Li J,Liu X,Chen L,Wang M,Xi J,Wang H,Zhang H,Zhu Y,Zhu W,Ning J,Guo C,Sun C,Zhang M

11-0038-80 was used in Cell Culture to suggest that the immunotherapy mediated by DC-CIK is safe and effective for cancer patients aged >65 years.

Thu Dec 01 00:00:00 EST 2016

Serum macrophage-derived chemokine/CCL22 levels are associated with glioma risk, CD4 T cell lymphopenia and survival time.

International journal of cancer

Zhou M,Bracci PM,McCoy LS,Hsuang G,Wiemels JL,Rice T,Zheng S,Kelsey KT,Wrensch MR,Wiencke JK

11-0038 was used in Flow cytometry/Cell sorting to study serum macrophage-derived chemokine/CCL22 levels which are associated with glioma risk, CD4 T cell lymphopenia and survival time.

Sat Aug 15 00:00:00 EDT 2015

Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection.

Nature communications

Miles B,Miller SM,Folkvord JM,Kimball A,Chamanian M,Meditz AL,Arends T,McCarter MD,Levy DN,Rakasz EG,Skinner PJ,Connick E

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Tue Oct 20 00:00:00 EDT 2015

Characterization of the in vivo immune network of IDO, tryptophan metabolism, PD-L1, and CTLA-4 in circulating immune cells in melanoma.

Oncoimmunology

Chevolet I,Speeckaert R,Schreuer M,Neyns B,Krysko O,Bachert C,Hennart B,Allorge D,van Geel N,Van Gele M,Brochez L

11-0038 was used in Flow cytometry/Cell sorting to demonstrate that the expression of IDO, PD-L1, and CTLA-4 in the peripheral blood of melanoma patients is strongly interconnected.

Sun Mar 01 00:00:00 EST 2015

Clinical significance of plasmacytoid dendritic cells and myeloid-derived suppressor cells in melanoma.

Journal of translational medicine

Chevolet I,Speeckaert R,Schreuer M,Neyns B,Krysko O,Bachert C,Van Gele M,van Geel N,Brochez L

11-0038 was used in Flow cytometry/Cell sorting to investigate multiple immune cell types in a series of blood samples from melanoma patients with different stages of the disease.

Fri Jan 16 00:00:00 EST 2015

Human mesenchymal stromal cells modulate T-cell responses through TNF-α-mediated activation of NF-κB.

European journal of immunology

Dorronsoro A,Ferrin I,Salcedo JM,Jakobsson E,Fernández-Rueda J,Lang V,Sepulveda P,Fechter K,Pennington D,Trigueros C

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Sat Feb 01 00:00:00 EST 2014

A comparison of DNA methylation specific droplet digital PCR (ddPCR) and real time qPCR with flow cytometry in characterizing human T cells in peripheral blood.

Epigenetics

Wiencke JK,Bracci PM,Hsuang G,Zheng S,Hansen H,Wrensch MR,Rice T,Eliot M,Kelsey KT

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Wed Oct 01 00:00:00 EDT 2014

Trypan blue exclusion assay by flow cytometry.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

Avelar-Freitas BA,Almeida VG,Pinto MC,Mourão FA,Massensini AR,Martins-Filho OA,Rocha-Vieira E,Brito-Melo GE

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Tue Apr 01 00:00:00 EDT 2014

Induction of type I and type III interferons by Borrelia burgdorferi correlates with pathogenesis and requires linear plasmid 36.

PloS one

Krupna-Gaylord MA,Liveris D,Love AC,Wormser GP,Schwartz I,Petzke MM

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Thu Mar 12 00:00:00 EDT 2015

Novel lentiviral vectors with mutated reverse transcriptase for mRNA delivery of TALE nucleases.

Scientific reports

Mock U,Riecken K,Berdien B,Qasim W,Chan E,Cathomen T,Fehse B

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Thu Sep 18 00:00:00 EDT 2014

Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR.

British journal of pharmacology

Vinet J,van Zwam M,Dijkstra IM,Brouwer N,van Weering HR,Watts A,Meijer M,Fokkens MR,Kannan V,Verzijl D,Vischer HF,Smit MJ,Leurs R,Biber K,Boddeke HW

11-0038 was used in Flow cytometry/Cell sorting to study the role of hCCX-CKR in hCXCR3-induced chemotaxis.

Fri Mar 01 00:00:00 EST 2013

Association of a NOD2 gene polymorphism and T-helper 17 cells with presumed ocular toxoplasmosis.

The Journal of infectious diseases

Dutra MS,Béla SR,Peixoto-Rangel AL,Fakiola M,Cruz AG,Gazzinelli A,Quites HF,Bahia-Oliveira LM,Peixe RG,Campos WR,Higino-Rocha AC,Miller NE,Blackwell JM,Antonelli LR,Gazzinelli RT

11-0038 was used in Flow cytometry/Cell sorting to suggest that NOD2 influences the production of IL-17A by CD4 T lymphocytes and might contribute to the development of ocular toxoplasmosis.

Tue Jan 01 00:00:00 EST 2013

Recombinant influenza virus carrying the respiratory syncytial virus (RSV) F85-93 CTL epitope reduces RSV replication in mice.

Journal of virology

De Baets S,Schepens B,Sedeyn K,Schotsaert M,Roose K,Bogaert P,Fiers W,Saelens X

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2013

Assessment of immune interference, antagonism, and diversion following human immunization with biallelic blood-stage malaria viral-vectored vaccines and controlled malaria infection.

Journal of immunology (Baltimore, Md. : 1950)

Elias SC,Collins KA,Halstead FD,Choudhary P,Bliss CM,Ewer KJ,Sheehy SH,Duncan CJ,Biswas S,Hill AV,Draper SJ

11-0038 was used in Flow cytometry/Cell sorting to study the effects of both controlled malaria infection, and human immunisation with biallelic blood-stage malaria viral-vectored vaccines, on the immune system.

Fri Feb 01 00:00:00 EST 2013

IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells.

Journal of immunology (Baltimore, Md. : 1950)

Tang XZ,Jo J,Tan AT,Sandalova E,Chia A,Tan KC,Lee KH,Gehring AJ,De Libero G,Bertoletti A

11-0038 was used in Flow cytometry/Cell sorting to investigate the function of human mucosal-associated invariant T (MAIT) cells in the human liver and peripheral blood, showing that MAIT cells express high levels of IL-7 receptor, which allows regulation of TCR activation of MAIT cells.

Mon Apr 01 00:00:00 EDT 2013

Evaluation of clinical and immunological responses: a 2-year follow-up study in children with allergic rhinitis due to house dust mite.

Mediators of inflammation

Moed H,Gerth van Wijk R,Hendriks RW,van der Wouden JC

11-0038 was used in Flow cytometry/Cell sorting to study allergic rhinitis clinical symptoms and associated in vivo/vitro skin and regulatory T cell responses respectively.

Tue Dec 03 00:00:00 EST 2013

MHC multimer-guided and cell culture-independent isolation of functional T cell receptors from single cells facilitates TCR identification for immunotherapy.

PloS one

Dössinger G,Bunse M,Bet J,Albrecht J,Paszkiewicz PJ,Weißbrich B,Schiedewitz I,Henkel L,Schiemann M,Neuenhahn M,Uckert W,Busch DH

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Flow Cytometry

Mon Nov 11 00:00:00 EST 2013

HER2 as a promising target for cytotoxicity T cells in human melanoma therapy.

PloS one

Ma J,Han H,Liu D,Li W,Feng H,Xue X,Wu X,Niu G,Zhang G,Zhao Y,Liu C,Tao H,Gao B

11-0038 was used in Flow cytometry/Cell sorting to study the expression of HER2 in a number of human melanoma cells and assess the suitability of HER2 as a target for melanoma immunotherapy.

Mon Mar 31 00:00:00 EDT 2014

Cytomegalovirus-specific T-cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells.

Hepatology (Baltimore, Md.)

Brindley SM,Lanham AM,Karrer FM,Tucker RM,Fontenot AP,Mack CL

11-0038 was used in Flow cytometry/Cell sorting to investigate the viral-induced pathogenesis of BA and mechanisms for its associated autoimmunity.

Sun Apr 01 00:00:00 EDT 2012

Decreased NK cells in patients with head and neck cancer determined in archival DNA.

Clinical cancer research : an official journal of the American Association for Cancer Research

Accomando WP,Wiencke JK,Houseman EA,Butler RA,Zheng S,Nelson HH,Kelsey KT

11-0038 was used in Flow cytometry/Cell sorting to investigate a significant depression in NK cells in HNSCC patients that is unrelated to exposures associated with the disease.

Thu Nov 15 00:00:00 EST 2012

Epigenetic biomarkers of T-cells in human glioma.

Epigenetics

Wiencke JK,Accomando WP,Zheng S,Patoka J,Dou X,Phillips JJ,Hsuang G,Christensen BC,Houseman EA,Koestler DC,Bracci P,Wiemels JL,Wrensch M,Nelson HH,Kelsey KT

11-0038 was used in Flow cytometry/Cell sorting to develop a new assay to capture glioma immune biology based on quantitative methylation specific PCR (qMSP) of two T-cell genes.

Sat Dec 01 00:00:00 EST 2012

Ulcerative colitis impairs the acylethanolamide-based anti-inflammatory system reversal by 5-aminosalicylic acid and glucocorticoids.

PloS one

Suárez J,Romero-Zerbo Y,Márquez L,Rivera P,Iglesias M,Bermúdez-Silva FJ,Andreu M,Rodríguez de Fonseca F

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Immunofluorescence

Thu Dec 13 00:00:00 EST 2012

Ulcerative colitis impairs the acylethanolamide-based anti-inflammatory system reversal by 5-aminosalicylic acid and glucocorticoids.

PloS one

Suárez J,Romero-Zerbo Y,Márquez L,Rivera P,Iglesias M,Bermúdez-Silva FJ,Andreu M,Rodríguez de Fonseca F

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Immunofluorescence

Thu Dec 13 00:00:00 EST 2012

Evidence for local dendritic cell activation in pulmonary sarcoidosis.

Respiratory research

Ten Berge B,Kleinjan A,Muskens F,Hammad H,Hoogsteden HC,Hendriks RW,Lambrecht BN,Van den Blink B

11-0038 was used in Flow cytometry/Cell sorting to determine whether, at sites of sarcoidosis, dendritic cells are involved in granuloma formation and maintenance.

Wed Apr 18 00:00:00 EDT 2012

Effects of NOD-like receptors in human B lymphocytes and crosstalk between NOD1/NOD2 and Toll-like receptors.

Journal of leukocyte biology

Petterson T,Jendholm J,Månsson A,Bjartell A,Riesbeck K,Cardell LO

11-0038 was used in Flow cytometry/Cell sorting to investigate how NLRs represent a new pathway for B cell activation and a potentially important host defense system against bacterial infections.

Tue Feb 01 00:00:00 EST 2011

Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease.

Hepatology (Baltimore, Md.)

Syn WK,Oo YH,Pereira TA,Karaca GF,Jung Y,Omenetti A,Witek RP,Choi SS,Guy CD,Fearing CM,Teaberry V,Pereira FE,Adams DH,Diehl AM

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Immunohistochemistry

Tue Jun 01 00:00:00 EDT 2010

Binding and uptake of H-ferritin are mediated by human transferrin receptor-1.

Proceedings of the National Academy of Sciences of the United States of America

Li L,Fang CJ,Ryan JC,Niemi EC,Lebrón JA,Björkman PJ,Arase H,Torti FM,Torti SV,Nakamura MC,Seaman WE

11-0038 was used in Flow cytometry/Cell sorting to demonstrate that TfR1 can bind HFt as well as Tf.

Tue Feb 23 00:00:00 EST 2010

Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus.

Arthritis research & therapy

Li Y,Lee PY,Kellner ES,Paulus M,Switanek J,Xu Y,Zhuang H,Sobel ES,Segal MS,Satoh M,Reeves WH

11-0038 was used in Flow cytometry/Cell sorting to identify a surrogate marker for IFN-I activity in clinical samples for monitoring lupus activity and response to therapy.

Wed Nov 24 00:00:00 EST 2010

Expansion of regulatory T cells in patients with Langerhans cell histiocytosis.

PLoS medicine

Senechal B,Elain G,Jeziorski E,Grondin V,Patey-Mariaud de Serre N,Jaubert F,Beldjord K,Lellouch A,Glorion C,Zerah M,Mary P,Barkaoui M,Emile JF,Boccon-Gibod L,Josset P,Debré M,Fischer A,Donadieu J,Geissmann F

Published figure using CD3 monoclonal antibody (Product # 11-0038-80) in Immunohistochemistry

Wed Aug 01 00:00:00 EDT 2007

T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment.

The American journal of tropical medicine and hygiene

Watanabe K,Mwinzi PN,Black CL,Muok EM,Karanja DM,Secor WE,Colley DG

11-0038 was used in Flow cytometry/Cell sorting to investigate the role of Tregs in Schistosoma mansoni infection, showing that Treg levels decrease in people on effective treatment.

Mon Oct 01 00:00:00 EDT 2007

Mycobacterium tuberculosis-induced gamma interferon production by natural killer cells requires cross talk with antigen-presenting cells involving Toll-like receptors 2 and 4 and the mannose receptor in tuberculous pleurisy.

Infection and immunity

Schierloh P,Yokobori N,Alemán M,Landoni V,Geffner L,Musella RM,Castagnino J,Baldini M,Abbate E,de la Barrera SS,Sasiain MC

11-0038 was used in Flow cytometry/Cell sorting to study how the interplay between M. tuberculosis and NK cells/APC triggering IFN-gamma may play a beneficial role in tuberculous pleurisy by helping to maintain a type 1 profile.

Thu Nov 01 00:00:00 EDT 2007

Bioinformatics

Protein Aliases: CD247; CD247 antigen, zeta subunit; CD3 antigen, delta subunit; CD3 delta; CD3 TCR complex; CD3-epsilon; CD3d; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); CD3e; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3g; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD3Z antigen, zeta polypeptide (TiT3 complex); CD3zeta chain; FLJ18683; Leu-4; OKT3, delta chain; T cell antigen receptor complex epsilon subunit of T3; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor T3 delta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T3/TCR complex; TCR zeta chain

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Gene Aliases: CD247; CD3-DELTA; CD3-GAMMA; CD3-ZETA; CD3D; CD3E; CD3G; CD3H; CD3Q; CD3Z; IMD17; IMD18; IMD19; IMD25; T3D; T3E; T3G; T3Z; TCRE; TCRZ

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UniProt ID: (Human) P20963, (Human) P04234, (Human) P07766, (Human) P09693

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Entrez Gene ID: (Human) 919, (Human) 915, (Human) 916, (Human) 917

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Function(s)

transmembrane signaling receptor activity protein binding identical protein binding protein homodimerization activity transcription coactivator activity protein heterodimerization activity receptor signaling protein activity SH3 domain binding protein kinase binding receptor signaling complex scaffold activity T cell receptor binding defense/immunity protein immunoglobulin receptor superfamily

Process(es)

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CD3 Monoclonal Antibody (UCHT1), FITC, eBioscience™

CD3 Antibody (11-0038-80) in Flow

Product Details

11-0038-80

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

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Bioinformatics

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