Product References
Impact of broad-spectrum antibiotics on the gut-microbiota-spleen-brain axis.
Brain, behavior, & immunity - health
Wan X,Eguchi A,Sakamoto A,Fujita Y,Yang Y,Qu Y,Hatano M,Mori C,Hashimoto K
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2023
Spleen-targeted neoantigen DNA vaccine for personalized immunotherapy of hepatocellular carcinoma.
EMBO molecular medicine
Wu M,Luo Z,Cai Z,Mao Q,Li Z,Li H,Zhang C,Zhang Y,Zhong A,Wu L,Liu X
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Oct 11 00:00:00 EDT 2023
CXCR1 drives the pathogenesis of EAE and ARDS via boosting dendritic cells-dependent inflammation.
Cell death & disease
Zhuang W,Zhou J,Zhong L,Lv J,Zhong X,Liu G,Xie L,Wang C,Saimaier K,Han S,Shi C,Hua Q,Zhang R,Xie X,Du C
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu Sep 14 00:00:00 EDT 2023
Platelet factors attenuate inflammation and rescue cognition in ageing.
Nature
Schroer AB,Ventura PB,Sucharov J,Misra R,Chui MKK,Bieri G,Horowitz AM,Smith LK,Encabo K,Tenggara I,Couthouis J,Gross JD,Chan JM,Luke A,Villeda SA
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2023
Klebsiella pneumoniae Induces Inflammatory Bowel Disease Through Caspase-11-Mediated IL18 in the Gut Epithelial Cells.
Cellular and molecular gastroenterology and hepatology
Zhang Q,Su X,Zhang C,Chen W,Wang Y,Yang X,Liu D,Zhang Y,Yang R
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu Feb 23 00:00:00 EST 2023
Icariin restrains NLRP3 inflammasome-mediated Th2 immune responses and ameliorates atopic dermatitis through modulating a novel lncRNA MALAT1/miR-124-3p axis.
Pharmaceutical biology
Zhao W,Yu HH,Meng WW,Liu AM,Zhang BX,Wang Y,Li J,Wang L,Fang YF
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Fri Dec 01 00:00:00 EST 2023
Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration.
Cell metabolism
Becker M,Joseph SS,Garcia-Carrizo F,Tom RZ,Opaleva D,Serr I,Tschöp MH,Schulz TJ,Hofmann SM,Daniel C
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Oct 03 00:00:00 EDT 2023
Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function.
British journal of pharmacology
Liao W,Foo HYC,Tran TNQ,Chai CLL,Wong WSF
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2023
ILC3s restrict the dissemination of intestinal bacteria to safeguard liver regeneration after surgery.
Cell reports
Jakob MO,Spari D,Sànchez Taltavull D,Salm L,Yilmaz B,Doucet Ladevèze R,Mooser C,Pereyra D,Ouyang Y,Schmidt T,Mattiola I,Starlinger P,Stroka D,Tschan F,Candinas D,Gasteiger G,Klose CSN,Diefenbach A,Gomez de Agüero M,Beldi G
12-0042-82 was used in Flow Cytometry to demonstrate that the failure to restrict intestinal commensals by ILC3s results in impaired liver regeneration.
Tue Mar 28 00:00:00 EDT 2023
Palmitoyl transferases act as novel drug targets for pancreatic cancer.
Journal of translational medicine
Lin Z,Lv Z,Liu X,Huang K
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon Apr 10 00:00:00 EDT 2023
SARS-CoV-2 spike protein promotes inflammatory cytokine activation and aggravates rheumatoid arthritis.
Cell communication and signaling : CCS
Lee AR,Woo JS,Lee SY,Lee YS,Jung J,Lee CR,Park SH,Cho ML
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu Mar 02 00:00:00 EST 2023
TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.
Frontiers in immunology
O'Neill TJ,Gewies A,Seeholzer T,Krappmann D
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon Feb 13 00:00:00 EST 2023
IFNγ Transcribed by IRF1 in CD4+ Effector Memory T Cells Promotes Senescence-Associated Pulmonary Fibrosis.
Aging and disease
Chen H,Wang Q,Li J,Li Y,Chen A,Zhou J,Zhao J,Mao Z,Zhou Z,Zhang J,Wang Y,Wang R,Li Q,Zhang Y,Jiang R,Miao D,Jin J
12-0042-82 was used in Flow Cytometry to find that physiological aging increased pulmonary CD4+ TEM cells, IFNγ was produced mainly by CD4+ TEM cells, and pulmonary cells had increased responsiveness to IFNγ signaling.
Fri Dec 01 00:00:00 EST 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2023
Aryl hydrocarbon receptor activation ameliorates experimental colitis by modulating the tolerogenic dendritic and regulatory T cell formation.
Cell & bioscience
Cui X,Ye Z,Wang D,Yang Y,Jiao C,Ma J,Tang N,Zhang H
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Sat Apr 23 00:00:00 EDT 2022
IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection.
Nature communications
Xu L,Wei C,Chen Y,Wu Y,Shou X,Chen W,Lu D,Sun H,Li W,Yu B,Wang X,Zhang X,Yu Y,Lei Z,Tang R,Zhu J,Li Y,Lu L,Zhou H,Zhou S,Su C,Chen X
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Sat Nov 12 00:00:00 EST 2022
Fringe GlcNAc-transferases differentially extend O-fucose on endogenous NOTCH1 in mouse activated T cells.
The Journal of biological chemistry
Matsumoto K,Kumar V,Varshney S,Nairn AV,Ito A,Pennarubia F,Moremen KW,Stanley P,Haltiwanger RS
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Fri Jul 01 00:00:00 EDT 2022
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling.
Nature communications
Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2022
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer.
Cancer immunology, immunotherapy : CII
Shi Y,Fu Y,Zhang X,Zhao G,Yao Y,Guo Y,Ma G,Bai S,Li H
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Potential therapeutic effects of interleukin-35 on the differentiation of naïve T cells into Helios+Foxp3+ Tregs in clinical and experimental acute respiratory distress syndrome.
Molecular immunology
Wang C,Xie K,Li K,Lin S,Xu F
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
Anisakis pegreffii Extract Induces Airway Inflammation with Airway Remodeling in a Murine Model System.
BioMed research international
Choi JH,Kim JY,Yi MH,Kim M,Yong TS
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Jan 12 00:00:00 EST 2022
Feline adipose tissue-derived mesenchymal stem cells pretreated with IFN-γ enhance immunomodulatory effects through the PGE₂ pathway.
Journal of veterinary science
Park SG,An JH,Li Q,Chae HK,Park SM,Lee JH,Ahn JO,Song WJ,Youn HY
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon Mar 01 00:00:00 EST 2021
Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.
The Journal of international medical research
Li W,Luo Y,Xu H,Ma Q,Yao Q
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation.
Theranostics
Chen L,Chen H,Ye J,Ge Y,Wang H,Dai E,Ren J,Liu W,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Aug 04 00:00:00 EDT 2021
Antitumor efficacy of a neoantigen cancer vaccine delivered by electroporation is influenced by microbiota composition.
Oncoimmunology
Lione L,Salvatori E,Petrazzuolo A,Massacci A,Maggio R,Confroti A,Compagnone M,Aurisicchio L,Ciliberto G,Palombo F
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Mar 23 00:00:00 EDT 2021
Evaluation of DNA-Launched Virus-Like Particle Vaccines in an Immune Competent Mouse Model of Chikungunya Virus Infection.
Vaccines
Rayner JO,Kim JH,Roberts RW,Wood RR,Fouty B,Solodushko V
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Fri Apr 02 00:00:00 EDT 2021
Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in Mice.
Frontiers in microbiology
Yu X,Zhou G,Shao B,Zhou H,Xu C,Yan F,Wang L,Chen G,Li J,Fu X
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed May 26 00:00:00 EDT 2021
Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.
EBioMedicine
Okada R,Furusawa A,Vermeer DW,Inagaki F,Wakiyama H,Kato T,Nagaya T,Choyke PL,Spanos WC,Allen CT,Kobayashi H
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Activation of Bone Marrow Adaptive Immunity in Type 2 Diabetes: Rescue by Co-stimulation Modulator Abatacept.
Frontiers in immunology
Santopaolo M,Sullivan N,Thomas AC,Alvino VV,Nicholson LB,Gu Y,Spinetti G,Kallikourdis M,Blom A,Madeddu P
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Fri Jul 02 00:00:00 EDT 2021
Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer.
Nature communications
Huang Y,Guan Z,Dai X,Shen Y,Wei Q,Ren L,Jiang J,Xiao Z,Jiang Y,Liu D,Huang Z,Xu X,Luo Y,Zhao C
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Jul 14 00:00:00 EDT 2021
Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE-/- mice in the presence and absence of immunomodulation with fingolimod.
Data in brief
Diaz Diaz AC,Malone K,Shearer JA,Moore AC,Waeber C
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Jun 01 00:00:00 EDT 2021
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon Dec 20 00:00:00 EST 2021
Integration of IL-2 and IL-4 signals coordinates divergent regulatory T cell responses and drives therapeutic efficacy.
eLife
Zhou JY,Alvarez CA,Cobb BA
12-0042-82 was used in Flow cytometry to determine that regulatory T cells integrate concurrent signaling initiated by IL-2 and IL-4 to generate a response divergent from the sum of the two pathways in isolation.
Mon Feb 22 00:00:00 EST 2021
Local Sustained GM-CSF Delivery by Genetically Engineered Encapsulated Cells Enhanced Both Cellular and Humoral SARS-CoV-2 Spike-Specific Immune Response in an Experimental Murine Spike DNA Vaccination Model.
Vaccines
Vernet R,Charrier E,Cosset E,Fièvre S,Tomasello U,Grogg J,Mach N
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon May 10 00:00:00 EDT 2021
Sequencing, cloning, and antigen binding analysis of monoclonal antibodies isolated from single mouse B cells.
STAR protocols
Viant C,Escolano A,Chen ST,Nussenzweig MC
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Fri Jun 18 00:00:00 EDT 2021
Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis.
Journal of neuroinflammation
Chen YH,Eskandarpour M,Zhang X,Galatowicz G,Greenwood J,Lightman S,Calder V
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu Feb 18 00:00:00 EST 2021
PRMT5 Promotes Cyclin E1 and Cell Cycle Progression in CD4 Th1 Cells and Correlates With EAE Severity.
Frontiers in immunology
Amici SA,Osman W,Guerau-de-Arellano M
12-0042-82 was used in Flow Cytometry to demonstrate the role of protein arginine N-methyltransferase 5 in T cell activation during multiple sclerosis.
Mon Dec 13 00:00:00 EST 2021
Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.
STAR protocols
Skordos I,Demeyer A,Beyaert R
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Fri Mar 19 00:00:00 EDT 2021
STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer.
Journal for immunotherapy of cancer
Lee SJ,Yang H,Kim WR,Lee YS,Lee WS,Kong SJ,Lee HJ,Kim JH,Cheon J,Kang B,Chon HJ,Kim C
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Jun 01 00:00:00 EDT 2021
Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.
PloS one
Cohen AA,Yang Z,Gnanapragasam PNP,Ou S,Dam KA,Wang H,Bjorkman PJ
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Fri Oct 15 00:00:00 EDT 2021
Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.
The Journal of clinical investigation
Webb LM,Sengupta S,Edell C,Piedra-Quintero ZL,Amici SA,Miranda JN,Bevins M,Kennemer A,Laliotis G,Tsichlis PN,Guerau-de-Arellano M
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.
The Journal of clinical investigation
Webb LM,Sengupta S,Edell C,Piedra-Quintero ZL,Amici SA,Miranda JN,Bevins M,Kennemer A,Laliotis G,Tsichlis PN,Guerau-de-Arellano M
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Methnaridine is an orally bioavailable, fast-killing and long-acting antimalarial agent that cures Plasmodium infections in mice.
British journal of pharmacology
Wang W,Yao J,Chen Z,Sun Y,Shi Y,Wei Y,Zhou H,Yu Y,Li S,Duan L
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2020
DKK2 blockage-mediated immunotherapy enhances anti-angiogenic therapy of Kras mutated colorectal cancer.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Hu J,Wang Z,Chen Z,Li A,Sun J,Zheng M,Wu J,Shen T,Qiao J,Li L,Li B,Wu D,Xiao Q
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Jul 01 00:00:00 EDT 2020
DKK2 blockage-mediated immunotherapy enhances anti-angiogenic therapy of Kras mutated colorectal cancer.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Hu J,Wang Z,Chen Z,Li A,Sun J,Zheng M,Wu J,Shen T,Qiao J,Li L,Li B,Wu D,Xiao Q
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Jul 01 00:00:00 EDT 2020
MOSPD2 is a therapeutic target for the treatment of CNS inflammation.
Clinical and experimental immunology
Yacov N,Kafri P,Salem Y,Propheta-Meiran O,Feldman B,Breitbart E,Mendel I
12-0042 was used in Flow cytometry/Cell sorting to study the therapeutic potential of MOSPD2 in central nervous system disease.
Sat Aug 01 00:00:00 EDT 2020
Increased Tim-3 expression on TILs during treatment with the Anchored GM-CSF vaccine and anti-PD-1 antibodies is inversely correlated with response in prostate cancer.
Journal of Cancer
Zhang X,Chen H,Li G,Zhou X,Shi Y,Zou F,Chen Y,Gao J,Yang S,Wu S,Long Z
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Sep 30 00:00:00 EDT 2020
Comparison of rapamycin and methylprednisolone for treating inflammatory muscle disease in a murine model of experimental autoimmune myositis.
Experimental and therapeutic medicine
Kang J,Feng D,Yang F,Tian X,Han W,Jia H
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Jul 01 00:00:00 EDT 2020
Effects of CD4+ T lymphocytes from ovariectomized mice on bone marrow mesenchymal stem cell proliferation and osteogenic differentiation.
Experimental and therapeutic medicine
Shao BY,Wang L,Yu Y,Chen L,Gan N,Huang WM
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2020
Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease.
Experimental and therapeutic medicine
Li W,Chen S,Luo Y,Xia Y,Ma Q,Yao Q,Wu J
12-0042-81 was used in Immunocytochemistry, Flow Cytometry to investigate the infiltration of T cells in lesions in the central nervous system, in patients with and without Parkinson's Disease.
Sat Aug 01 00:00:00 EDT 2020
Interaction between ICAM1 in endothelial cells and LFA1 in T cells during the pathogenesis of experimental Parkinson's disease.
Experimental and therapeutic medicine
Li W,Chen S,Luo Y,Xia Y,Ma Q,Yao Q,Wu J
12-0042-81 was used in Immunocytochemistry, Flow Cytometry to investigate the infiltration of T cells in lesions in the central nervous system, in patients with and without Parkinson's Disease.
Sat Aug 01 00:00:00 EDT 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu Sep 17 00:00:00 EDT 2020
Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety.
Journal for immunotherapy of cancer
Ge Y,Wang H,Ren J,Liu W,Chen L,Chen H,Ye J,Dai E,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Sun Mar 01 00:00:00 EST 2020
A novel antibody targeting TIM-3 resulting in receptor internalization for cancer immunotherapy.
Antibody therapeutics
Kuang Z,Li L,Zhang P,Chen B,Wu M,Ni H,Yi S,Zou J,Liu J
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2020
Mechanisms of interleukin 4 mediated increase in efficacy of vaccines against opioid use disorders.
NPJ vaccines
Crouse B,Robinson C,Huseby Kelcher A,Laudenbach M,Abrahante JE,Pravetoni M
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu Oct 29 00:00:00 EDT 2020
CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.
Frontiers in immunology
Shapiro MR,Yeh WI,Longfield JR,Gallagher J,Infante CM,Wellford S,Posgai AL,Atkinson MA,Campbell-Thompson M,Lieberman SM,Serreze DV,Geurts AM,Chen YG,Brusko TM
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed May 26 00:00:00 EDT 2021
Distinct actions of the fermented beverage kefir on host behaviour, immunity and microbiome gut-brain modules in the mouse.
Microbiome
van de Wouw M,Walsh AM,Crispie F,van Leuven L,Lyte JM,Boehme M,Clarke G,Dinan TG,Cotter PD,Cryan JF
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon May 18 00:00:00 EDT 2020
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.
Nature communications
Iske J,Seyda M,Heinbokel T,Maenosono R,Minami K,Nian Y,Quante M,Falk CS,Azuma H,Martin F,Passos JF,Niemann CU,Tchkonia T,Kirkland JL,Elkhal A,Tullius SG
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu Aug 27 00:00:00 EDT 2020
Loss of testosterone impairs anti-tumor neutrophil function.
Nature communications
Markman JL,Porritt RA,Wakita D,Lane ME,Martinon D,Noval Rivas M,Luu M,Posadas EM,Crother TR,Arditi M
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Mar 31 00:00:00 EDT 2020
STING couples with PI3K to regulate actin reorganization during BCR activation.
Science advances
Jing Y,Dai X,Yang L,Kang D,Jiang P,Li N,Cheng J,Li J,Miller H,Ren B,Gong Q,Yin W,Liu Z,Mattila PK,Ning Q,Sun J,Yu B,Liu C
12-0042 was used in Immunohistochemistry to study the effect of STING (stimulator of interferon genes) deficiency on B cell development, differentiation, and BCR signalling.
Wed Apr 01 00:00:00 EDT 2020
STING couples with PI3K to regulate actin reorganization during BCR activation.
Science advances
Jing Y,Dai X,Yang L,Kang D,Jiang P,Li N,Cheng J,Li J,Miller H,Ren B,Gong Q,Yin W,Liu Z,Mattila PK,Ning Q,Sun J,Yu B,Liu C
12-0042 was used in Immunohistochemistry to study the effect of STING (stimulator of interferon genes) deficiency on B cell development, differentiation, and BCR signalling.
Wed Apr 01 00:00:00 EDT 2020
A Commercial Probiotic Induces Tolerogenic and Reduces Pathogenic Responses in Experimental Autoimmune Encephalomyelitis.
Cells
Calvo-Barreiro L,Eixarch H,Ponce-Alonso M,Castillo M,Lebrón-Galán R,Mestre L,Guaza C,Clemente D,Del Campo R,Montalban X,Espejo C
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Apr 07 00:00:00 EDT 2020
Mouse Double Minute 2 Homolog-Mediated Ubiquitination Facilitates Forkhead Box P3 Stability and Positively Modulates Human Regulatory T Cell Function.
Frontiers in immunology
Wang A,Yang M,Liang R,Zhu F,Zhu F,Liu X,Han Y,Lin R,Wang X,Li D,Li H,Yuan X,Zhao H,Li B
12-0042 was used in Flow cytometry/Cell sorting to investigate how mouse double minute 2 homolog effects the function of regulatory T cells.
Mon Apr 05 00:00:00 EDT 2021
Axenic Caenorhabditis elegans antigen protects against development of type-1 diabetes in NOD mice.
Journal of translational autoimmunity
Jackson-Thompson BM,Torrero M,Mitre BK,Long J,Packiam M,Mitre E
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon Sep 28 00:00:00 EDT 2020
Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity.
Cell
Brown CC,Gudjonson H,Pritykin Y,Deep D,Lavallée VP,Mendoza A,Fromme R,Mazutis L,Ariyan C,Leslie C,Pe'er D,Rudensky AY
12-0042 was used in Flow cytometry/Cell sorting to identify two principal cDC2 lineages defined by distinct developmental pathways and transcriptional regulators, including T-bet and RORγt, two key transcription factors known to define innate and adaptive lymphocyte subsets.
Thu Oct 31 00:00:00 EDT 2019
The cis-Regulatory Atlas of the Mouse Immune System.
Cell
Yoshida H,Lareau CA,Ramirez RN,Rose SA,Maier B,Wroblewska A,Desland F,Chudnovskiy A,Mortha A,Dominguez C,Tellier J,Kim E,Dwyer D,Shinton S,Nabekura T,Qi Y,Yu B,Robinette M,Kim KW,Wagers A,Rhoads A,Nutt SL,Brown BD,Mostafavi S,Buenrostro JD,Benoist C
12-0042-82 was used in Flow Cytometry to generate matched epigenome and transcriptome measurements in 86 primary cell types that span the mouse immune system and its differentiation cascade.
Thu Feb 07 00:00:00 EST 2019
Engulfment of mast cell secretory granules on skin inflammation boosts dendritic cell migration and priming efficiency.
The Journal of allergy and clinical immunology
Dudeck J,Froebel J,Kotrba J,Lehmann CHK,Dudziak D,Speier S,Nedospasov SA,Schraven B,Dudeck A
12-0042 was used in Flow cytometry/Cell sorting to show peripheral mast cells can modify dendritic cell functionality to influence lymphoid tissue-borne adaptive immunity.
Wed May 01 00:00:00 EDT 2019
Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice.
Genome research
Alriyami M,Marchand L,Li Q,Du X,Olivier M,Polychronakos C
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Sun Dec 01 00:00:00 EST 2019
High dietary vitamin C intake reduces glucocorticoid-induced immunosuppression and measures of oxidative stress in vitamin C-deficient senescence marker protein 30 knockout mice.
The British journal of nutrition
Uchio R,Hirose Y,Murosaki S,Ishigami A
12-0042 was used in Flow cytometry/Cell sorting to evaluate the effect of high VC intake on glucocorticoid-induced immune changes in mice.
Thu Nov 28 00:00:00 EST 2019
A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia.
JCI insight
Yin M,Baslan T,Walker RL,Zhu YJ,Freeland A,Matsukawa T,Sridharan S,Nussenzweig A,Pruitt SC,Lowe SW,Meltzer PS,Aplan PD
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu Dec 05 00:00:00 EST 2019
Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction.
Frontiers in immunology
Fenninger F,Han J,Stanwood SR,Nohara LL,Arora H,Choi KB,Munro L,Pfeifer CG,Shanina I,Horwitz MS,Jefferies WA
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu Oct 29 00:00:00 EDT 2020
Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis.
Scientific reports
Brichacek AL,Benkovic SA,Chakraborty S,Nwafor DC,Wang W,Jun S,Dakhlallah D,Geldenhuys WJ,Pinkerton AB,Millán JL,Brown CM
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Dec 11 00:00:00 EST 2019
Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases.
Scientific reports
Park TY,Jang Y,Kim W,Shin J,Toh HT,Kim CH,Yoon HS,Leblanc P,Kim KS
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Oct 29 00:00:00 EDT 2019
Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR.
Nature communications
Zhu H,Bhatt B,Sivaprakasam S,Cai Y,Liu S,Kodeboyina SK,Patel N,Savage NM,Sharma A,Kaufman RJ,Li H,Singh N
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Mar 06 00:00:00 EST 2019
Neutralizing monoclonal antibody against Dickkopf2 impairs lung cancer progression via activating NK cells.
Cell death discovery
Shen T,Chen Z,Qiao J,Sun X,Xiao Q
12-0042-82 was used in Flow cytometry/Cell sorting to determine whether approaches targeting dysregulated adenomatous polyposis coli (APC) pathways are also applicable to non-small cell lung cancer patients harboring similar mutations of APC.
Tue Feb 13 00:00:00 EST 2024
The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells.
Cell reports
Araujo LP,Maricato JT,Guereschi MG,Takenaka MC,Nascimento VM,de Melo FM,Quintana FJ,Brum PC,Basso AS
12-0042-82 was used in Flow Cytometry to uncover a suppressive role for the SNS in CNS autoimmunity while they identify potential targets for therapeutic intervention.
Tue Sep 17 00:00:00 EDT 2019
DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation.
Nature medicine
Xiao Q,Wu J,Wang WJ,Chen S,Zheng Y,Yu X,Meeth K,Sahraei M,Bothwell ALM,Chen L,Bosenberg M,Chen J,Sexl V,Sun L,Li L,Tang W,Wu D
12-0042 was used in Flow cytometry/Cell sorting to identify a novel tumour immune-suppressive mechanism and immunotherapeutic targets particularly relevant for colorectal cancers and a subset of melanomas.
Thu Mar 01 00:00:00 EST 2018
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu Jun 28 00:00:00 EDT 2018
T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation.
Immunity
Shimada K,Porritt RA,Markman JL,O'Rourke JG,Wakita D,Noval Rivas M,Ogawa C,Kozhaya L,Martins GA,Unutmaz D,Baloh RH,Crother TR,Chen S,Arditi M
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Nov 20 00:00:00 EST 2018
TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4+CD8+ thymocytes.
Nature immunology
Emmanuel AO,Arnovitz S,Haghi L,Mathur PS,Mondal S,Quandt J,Okoreeh MK,Maienschein-Cline M,Khazaie K,Dose M,Gounari F
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Sat Dec 01 00:00:00 EST 2018
Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5.
The Journal of experimental medicine
Buxadé M,Huerga Encabo H,Riera-Borrull M,Quintana-Gallardo L,López-Cotarelo P,Tellechea M,Martínez-Martínez S,Redondo JM,Martín-Caballero J,Flores JM,Bosch E,Rodríguez-Fernández JL,Aramburu J,López-Rodríguez C
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon Nov 05 00:00:00 EST 2018
STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research
Moreira D,Adamus T,Zhao X,Su YL,Zhang Z,White SV,Swiderski P,Lu X,DePinho RA,Pal SK,Kortylewski M
12-0042 was used in Flow cytometry/Cell sorting to show a novel strategy combining STAT3 inhibition with Toll-like Receptor 9 (TLR9) stimulation to unleash immune response against prostate cancers regardless of the genetic background.
Sat Dec 01 00:00:00 EST 2018
In Vitro Priming of Adoptively Transferred T Cells with a RORγ Agonist Confers Durable Memory and Stemness In Vivo.
Cancer research
Hu X,Majchrzak K,Liu X,Wyatt MM,Spooner CJ,Moisan J,Zou W,Carter LL,Paulos CM
12-0042 was used in Flow cytometry/Cell sorting to demonstrate that addition of a synthetic, small-molecule RORγ agonist during ex vivo expansion potentiates the anti-tumour activity of human Th17 and Tc17 cells redirected with a chimeric antigen receptor.
Sun Jul 15 00:00:00 EDT 2018
Bryostatin-1 alleviates experimental multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America
Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Feb 27 00:00:00 EST 2018
Quantitative Methods for Measuring Repair Rates and Innate-Immune Cell Responses in Wounded Mouse Skin.
Frontiers in immunology
Li Z,Gothard E,Coles MC,Ambler CA
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Mar 27 00:00:00 EDT 2019
Protease-activated receptor-2 signaling through β-arrestin-2 mediates Alternaria alkaline serine protease-induced airway inflammation.
American journal of physiology. Lung cellular and molecular physiology
Yee MC,Nichols HL,Polley D,Saifeddine M,Pal K,Lee K,Wilson EH,Daines MO,Hollenberg MD,Boitano S,DeFea KA
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Sat Dec 01 00:00:00 EST 2018
Effects of different principles of Traditional Chinese Medicine treatment on TLR7/NF-κB signaling pathway in influenza virus infected mice.
Chinese medicine
Fu YJ,Yan YQ,Qin HQ,Wu S,Shi SS,Zheng X,Wang PC,Chen XY,Tang XL,Jiang ZY
12-0042 was used in Flow cytometry/Cell sorting to show traditional chinese medicines Guizhi-and-Mahuang decoction and Yinqiao powder can provide anti-influenza functions.
Mon Mar 21 00:00:00 EDT 2022
Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice.
Journal of neuroimmunology
Kiyota T,Machhi J,Lu Y,Dyavarshetty B,Nemati M,Yokoyama I,Mosley RL,Gendelman HE
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Fri Jun 15 00:00:00 EDT 2018
Immunological effects of a low-dose cytarabine, aclarubicin and granulocyte-colony stimulating factor priming regimen on a mouse leukemia model.
Oncology letters
Chen J,Yang N,Liu H,Yao H,Wang J,Yang Y,Zhang W
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
Protective function of Bu Shen Huo Xue formula on the immunity of B6AF1 mice with experimental autoimmune premature ovarian failure.
Experimental and therapeutic medicine
Wang P,Lu Y,Chen S,Chen Y,Hu C,Zuo Y
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2018
Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene.
Nature communications
Kojo S,Yasmin N,Muroi S,Tenno M,Taniuchi I
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Sep 05 00:00:00 EDT 2018
Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.
Nature communications
Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu Nov 08 00:00:00 EST 2018
Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation.
Cell death & disease
Ding Y,Liang X,Zhang Y,Yi L,Shum HC,Chen Q,Chan BP,Fan H,Liu Z,Tergaonkar V,Qi Z,Tse HF,Lian Q
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Mar 07 00:00:00 EST 2018
TLR3 Regulated Poly I:C-Induced Neutrophil Extracellular Traps and Acute Lung Injury Partly Through p38 MAP Kinase.
Frontiers in microbiology
Gan T,Yang Y,Hu F,Chen X,Zhou J,Li Y,Xu Y,Wang H,Chen Y,Zhang M
12-0042-82 was used in Flow Cytometry to demonstrate that poly I:C can induce pulmonary neutrophil extracellular traps.
Thu Oct 01 00:00:00 EDT 2020
Efficient immunoaffinity chromatography of lymphocytes directly from whole blood.
Scientific reports
Mohr F,Przibilla S,Leonhardt F,Stemberger C,Dreher S,Müller TR,Fräßle SP,Schmidt GP,Kiene ML,Stadler H,Busch DH
12-0042 was used in Flow cytometry/Cell sorting to show that defined lymphocytes can be rapidly purified by immunoaffinity chromatography starting directly from whole blood.
Tue Nov 13 00:00:00 EST 2018
CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties.
Cell stem cell
Wakabayashi T,Naito H,Suehiro JI,Lin Y,Kawaji H,Iba T,Kouno T,Ishikawa-Kato S,Furuno M,Takara K,Muramatsu F,Weizhen J,Kidoya H,Ishihara K,Hayashizaki Y,Nishida K,Yoder MC,Takakura N
12-0042-82 was used in Flow cytometry/Cell sorting to show that tissue-resident VESCs display self-renewal capacity and that vascular regeneration potential exists in peripheral blood vessels.
Thu Mar 01 00:00:00 EST 2018
Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling.
Cell
Ho CCM,Chhabra A,Starkl P,Schnorr PJ,Wilmes S,Moraga I,Kwon HS,Gaudenzio N,Sibilano R,Wehrman TS,Gakovic M,Sockolosky JT,Tiffany MR,Ring AM,Piehler J,Weissman IL,Galli SJ,Shizuru JA,Garcia KC
12-0042 was used in Flow cytometry/Cell sorting to develop a mechanism-based stem cell factor partial agonist that impairs c-Kit dimerisation, truncating downstream signalling amplitude.
Thu Mar 09 00:00:00 EST 2017
Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis.
Immunity
Kishore M,Cheung KCP,Fu H,Bonacina F,Wang G,Coe D,Ward EJ,Colamatteo A,Jangani M,Baragetti A,Matarese G,Smith DM,Haas R,Mauro C,Wraith DC,Okkenhaug K,Catapano AL,De Rosa V,Norata GD,Marelli-Berg FM
12-0042 was used in Flow cytometry to demonstrate that glucokinase-dependent glycolysis regulates regulatory T cell migration.
Tue Nov 21 00:00:00 EST 2017
Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment.
The Journal of clinical investigation
Wang YT,Chen J,Chang CW,Jen J,Huang TY,Chen CM,Shen R,Liang SY,Cheng IC,Yang SC,Lai WW,Cheng KH,Hsieh TS,Lai MZ,Cheng HC,Wang YC,Chen RH
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2017
Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.
The Journal of clinical investigation
Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
IL-36 Signaling Facilitates Activation of the NLRP3 Inflammasome and IL-23/IL-17 Axis in Renal Inflammation and Fibrosis.
Journal of the American Society of Nephrology : JASN
Chi HH,Hua KF,Lin YC,Chu CL,Hsieh CY,Hsu YJ,Ka SM,Tsai YL,Liu FC,Chen A
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Sat Jul 01 00:00:00 EDT 2017
Differentiation of IL-17-Producing Invariant Natural Killer T Cells Requires Expression of the Transcription Factor c-Maf.
Frontiers in immunology
Yu JS,Hamada M,Ohtsuka S,Yoh K,Takahashi S,Miaw SC
12-0042 was used in Flow cytometry/Cell sorting to show that c-Maf is a positive regulator for the expression of IL-17A and RORγt in iNKT17 cells, and is a potential therapeutic target in iNKT17 cell-mediated inflammatory disease.
Wed Nov 20 00:00:00 EST 2019
IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury.
Frontiers in neurology
Gao W,Li F,Zhou Z,Xu X,Wu Y,Zhou S,Yin D,Sun D,Xiong J,Jiang R,Zhang J
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
Discrimination of the heterogeneity of bone marrow‑derived dendritic cells.
Molecular medicine reports
Wang J,Dai X,Hsu C,Ming C,He Y,Zhang J,Wei L,Zhou P,Wang CY,Yang J,Gong N
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Nov 01 00:00:00 EDT 2017
Immunological effects of vaccines combined with granulocyte colony-stimulating factor on a murine WEHI-3 leukemia model.
Oncology letters
Chen J,Zhang M,Zhou F,Wang J,Niu B,Zhang W
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2017
Effect of follicular helper T cells on the pathogenesis of asthma.
Experimental and therapeutic medicine
Ma X,Sun Z,Zhai P,Yu W,Wang T,Li F,Ding J
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2017
IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.
JCI insight
Le Saout C,Luckey MA,Villarino AV,Smith M,Hasley RB,Myers TG,Imamichi H,Park JH,O'Shea JJ,Lane HC,Catalfamo M
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu Nov 16 00:00:00 EST 2017
Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.
Nature communications
Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Oct 17 00:00:00 EDT 2017
Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.
Nature communications
Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Oct 17 00:00:00 EDT 2017
Batf3-dependent CD8α+ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.
EBioMedicine
Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2017
Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting.
Scientific reports
Atkin-Smith GK,Paone S,Zanker DJ,Duan M,Phan TK,Chen W,Hulett MD,Poon IK
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Fri Jan 06 00:00:00 EST 2017
Blocking IL-10 signalling at the time of immunization does not increase unwanted side effects in mice.
BMC immunology
Ni G,Liao Z,Chen S,Wang T,Yuan J,Pan X,Mounsey K,Cavezza S,Liu X,Wei MQ
12-0042 was used in Flow cytometry/Cell sorting to determine the effect of blocking IL-10 during immunisation on intestinal inflammation responses.
Tue Aug 15 00:00:00 EDT 2017
Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles.
Scientific reports
Costa-Gouveia J,Pancani E,Jouny S,Machelart A,Delorme V,Salzano G,Iantomasi R,Piveteau C,Queval CJ,Song OR,Flipo M,Deprez B,Saint-André JP,Hureaux J,Majlessi L,Willand N,Baulard A,Brodin P,Gref R
12-0042 was used in Flow cytometry/Cell sorting to pave the way for a future use of pCD NPs for the pulmonary delivery of the [ETH:Booster] pair in TB chemotherapy.
Fri Jul 14 00:00:00 EDT 2017
CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis.
Nature immunology
Cibrian D,Saiz ML,de la Fuente H,Sánchez-Díaz R,Moreno-Gonzalo O,Jorge I,Ferrarini A,Vázquez J,Punzón C,Fresno M,Vicente-Manzanares M,Daudén E,Fernández-Salguero PM,Martín P,Sánchez-Madrid F
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
Oligodendrocyte death results in immune-mediated CNS demyelination.
Nature neuroscience
Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.
Science translational medicine
Dendrou CA,Cortes A,Shipman L,Evans HG,Attfield KE,Jostins L,Barber T,Kaur G,Kuttikkatte SB,Leach OA,Desel C,Faergeman SL,Cheeseman J,Neville MJ,Sawcer S,Compston A,Johnson AR,Everett C,Bell JI,Karpe F,Ultsch M,Eigenbrot C,McVean G,Fugger L
12-0042 was used in Flow cytometry/Cell sorting to reveal a protective homozygous effect that defined a signalling optimum between autoimmunity and immunodeficiency and identified TYK2 as a potential drug target for autoimmune disorders.
Wed Nov 02 00:00:00 EDT 2016
STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides.
Clinical cancer research : an official journal of the American Association for Cancer Research
Vieyra-Garcia PA,Wei T,Naym DG,Fredholm S,Fink-Puches R,Cerroni L,Odum N,O'Malley JT,Gniadecki R,Wolf P
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Fri Jul 01 00:00:00 EDT 2016
Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model.
Molecular medicine reports
Yue Y,Li P,Song N,Li B,Li Z,Guo Y,Zhang W,Wei MQ,Gai Z,Meng H,Wang J,Qin L
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Sun May 01 00:00:00 EDT 2016
Development of a diet-induced murine model of diabetes featuring cardinal metabolic and pathophysiological abnormalities of type 2 diabetes.
Biology open
Morris JL,Bridson TL,Alim MA,Rush CM,Rudd DM,Govan BL,Ketheesan N
12-0042 was used in Flow cytometry/Cell sorting to develop a novel murine model, based on an energy-dense diet, which closely simulates the development of type 2 diabetes.
Mon Aug 15 00:00:00 EDT 2016
Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.
Nature communications
Baptista MA,Keszei M,Oliveira M,Sunahara KK,Andersson J,Dahlberg CI,Worth AJ,Liedén A,Kuo IC,Wallin RP,Snapper SB,Eidsmo L,Scheynius A,Karlsson MC,Bouma G,Burns SO,Forsell MN,Thrasher AJ,Nylén S,Westerberg LS
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon Jul 18 00:00:00 EDT 2016
Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.
eLife
Allison KA,Sajti E,Collier JG,Gosselin D,Troutman TD,Stone EL,Hedrick SM,Glass CK
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon Jul 04 00:00:00 EDT 2016
Induction of Suppressor Cells and Increased Tumor Growth following Chronic Psychosocial Stress in Male Mice.
PloS one
Schmidt D,Peterlik D,Reber SO,Lechner A,Männel DN
12-0042 was used in Flow cytometry/Cell sorting to observe the immunological effects of chronic psychosocial stress in mice.
Fri Aug 18 00:00:00 EDT 2017
Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator.
Nature communications
Zhu ML,Bakhru P,Conley B,Nelson JS,Free M,Martin A,Starmer J,Wilson EM,Su MA
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Apr 13 00:00:00 EDT 2016
Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator.
Nature communications
Zhu ML,Bakhru P,Conley B,Nelson JS,Free M,Martin A,Starmer J,Wilson EM,Su MA
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Apr 13 00:00:00 EDT 2016
Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma.
Oncoimmunology
Vandenberk L,Garg AD,Verschuere T,Koks C,Belmans J,Beullens M,Agostinis P,De Vleeschouwer S,Van Gool SW
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2016
Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination.
Scientific reports
Stifter K,Schuster C,Schlosser M,Boehm BO,Schirmbeck R
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon Jul 11 00:00:00 EDT 2016
Critical role of phospholipase A2 group IID in age-related susceptibility to severe acute respiratory syndrome-CoV infection.
The Journal of experimental medicine
Vijay R,Hua X,Meyerholz DK,Miki Y,Yamamoto K,Gelb M,Murakami M,Perlman S
12-0042 was used in Flow cytometry/Cell sorting to investigate the enhanced expression of proresolving/antiinflammatory factors in ageing, showing a critical role of phospholipase A2 group IID.
Mon Oct 19 00:00:00 EDT 2015
Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.
Cardiovascular research
Wan W,Liu Q,Lionakis MS,Marino AP,Anderson SA,Swamydas M,Murphy PM
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2015
Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.
Frontiers in immunology
Vogel AJ,Brown DM
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Fri Jul 10 00:00:00 EDT 2015
Hind limb unloading, a model of spaceflight conditions, leads to decreased B lymphopoiesis similar to aging.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Lescale C,Schenten V,Djeghloul D,Bennabi M,Gaignier F,Vandamme K,Strazielle C,Kuzniak I,Petite H,Dosquet C,Frippiat JP,Goodhardt M
12-0042 was used in Flow cytometry/Cell sorting to demonstrate that mechanical unloading of hind limbs results in a decrease in early B-cell differentiation resembling age-related modifications in B lymphopoiesis.
Sun Feb 01 00:00:00 EST 2015
Haploinsufficiency for Stard7 is associated with enhanced allergic responses in lung and skin.
Journal of immunology (Baltimore, Md. : 1950)
Yang L,Lewkowich I,Apsley K,Fritz JM,Wills-Karp M,Weaver TE
12-0042 was used in Flow cytometry/Cell sorting to determine whether loss of Stard7 expression promotes allergic responses, showing that haploinsufficiency for Stard7 is associated with enhanced allergic responses.
Mon Jun 15 00:00:00 EDT 2015
A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells.
Cancer biology & therapy
Kawahara M,Takaku H
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon Sep 12 00:00:00 EDT 2016
Inadequate activation of the HBsAg-specific Th cells by APCs leads to hyporesponsiveness to HBsAg vaccine in B10.S mice.
Human vaccines & immunotherapeutics
Li X,Xu J,Lv Z,Wang J,Sun S,Zhu W,Wang B,He R,Qu D
12-0042 was used in Flow cytometry/Cell sorting to study how the activities of APCs were significantly lower in mice immunised with HBsAg vaccine, resulting in an inferior activation of HBsAg-specific Th cells.
Tue Apr 19 00:00:00 EDT 2016
Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.
Human vaccines & immunotherapeutics
Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Fri Mar 11 00:00:00 EST 2016
Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.
Gene therapy
Rodriguez-Peña AB,Gomez-Rodriguez J,Kortum RL,Palmer DC,Yu Z,Guittard GC,Wohlfert EA,Silver PB,Misplon JA,Sommers CL,Feigenbaum L,Epstein SL,Caspi RR,Belkaid Y,Restifo NP,Samelson LE,Balagopalan L
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2015
Recombinant adeno-vaccine expressing enterovirus 71-like particles against hand, foot, and mouth disease.
PLoS neglected tropical diseases
Tsou YL,Lin YW,Shao HY,Yu SL,Wu SR,Lin HY,Liu CC,Huang C,Chong P,Chow YH
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2015
dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.
Nature communications
Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Sep 15 00:00:00 EDT 2015
Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation.
eLife
He L,Zhang Y,Ma G,Tan P,Li Z,Zang S,Wu X,Jing J,Fang S,Zhou L,Wang Y,Huang Y,Hogan PG,Han G,Zhou Y
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Dec 08 00:00:00 EST 2015
The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.
Nature immunology
Salmond RJ,Brownlie RJ,Morrison VL,Zamoyska R
12-0042 was used in Flow cytometry/Cell sorting to study how loss-of-function PTPN22 alleles can lead to the population expansion of effector and/or memory T cells and a predisposition to human autoimmunity.
Mon Sep 01 00:00:00 EDT 2014
Peptidylarginine deiminase 4 contributes to tumor necrosis factor α-induced inflammatory arthritis.
Arthritis & rheumatology (Hoboken, N.J.)
Shelef MA,Sokolove J,Lahey LJ,Wagner CA,Sackmann EK,Warner TF,Wang Y,Beebe DJ,Robinson WH,Huttenlocher A
12-0042 was used in Flow cytometry/Cell sorting to investigate whether TNFα and PAD4 may synergistically exacerbate autoantibody production and inflammatory arthritis, showing that PAD4 contributes to TNFα-induced inflammatory arthritis.
Sun Jun 01 00:00:00 EDT 2014
TLR7 ligand augments GM-CSF-initiated antitumor immunity through activation of plasmacytoid dendritic cells.
Cancer immunology research
Narusawa M,Inoue H,Sakamoto C,Matsumura Y,Takahashi A,Inoue T,Watanabe A,Miyamoto S,Miura Y,Hijikata Y,Tanaka Y,Inoue M,Takayama K,Okazaki T,Hasegawa M,Nakanishi Y,Tani K
12-0042 was used in Flow cytometry/Cell sorting to study how the additional use of imiquimod to activate plasmacytoid dendritic cells with type I IFN production could enhance the immunologic antitumor effects of GVAX therapy.
Sun Jun 01 00:00:00 EDT 2014
Immune enhancement activities of silk lutein extract from Bombyx mori cocoons.
Biological research
Promphet P,Bunarsa S,Sutheerawattananonda M,Kunthalert D
12-0042 was used in Flow cytometry/Cell sorting to study how silk lutein extract from Bombyx mori cocoons enhanced both innate and adaptive immune functions.
Mon Apr 28 00:00:00 EDT 2014
TLR2 engagement on CD4(+) T cells enhances effector functions and protective responses to Mycobacterium tuberculosis.
European journal of immunology
Reba SM,Li Q,Onwuzulike S,Ding X,Karim AF,Hernandez Y,Fulton SA,Harding CV,Lancioni CL,Nagy N,Rodriguez ME,Wearsch PA,Rojas RE
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu May 01 00:00:00 EDT 2014
IL-18 enhances immunosuppressive responses by promoting differentiation into monocytic myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Lim HX,Hong HJ,Cho D,Kim TS
12-0042 was used in Flow cytometry/Cell sorting to study the role of IL-18 in mediating immunosuppression via specifically enhancing the differentiation and function of monocytic myeloid-derived suppressor cells.
Mon Dec 01 00:00:00 EST 2014
Regulatory T cells shape the resident memory T cell response to virus infection in the tissues.
Journal of immunology (Baltimore, Md. : 1950)
Graham JB,Da Costa A,Lund JM
12-0042 was used in Flow cytometry/Cell sorting to demonstrate that Treg-dependent production of TGF-β results in increased expression of CD103 on CD8(+) T cells.
Wed Jan 15 00:00:00 EST 2014
Systemic sensitization with the protein allergen ovalbumin augments local sensitization in atopic dermatitis.
Journal of inflammation research
Yoo J,Manicone AM,McGuire JK,Wang Y,Parks WC
12-0042 was used in Flow cytometry/Cell sorting to reveal a mouse model of atopic dermatitis that reveals novel insights into the pathogenesis of this complex disease.
Thu Mar 27 00:00:00 EDT 2014
Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.
PloS one
Ikeda T,Hirata S,Takamatsu K,Haruta M,Tsukamoto H,Ito T,Uchino M,Ando Y,Nagafuchi S,Nishimura Y,Senju S
12-0042 was used in Flow cytometry/Cell sorting to investigate the effect of embryonic stem cell-derived dendritic cells on autoimmunity, showing that suppression of Th1-mediated autoimmunity occurs in NOD and EAE mice.
Thu Dec 17 00:00:00 EST 2015
Anti-melanoma vaccines engineered to simultaneously modulate cytokine priming and silence PD-L1 characterized using ex vivo myeloid-derived suppressor cells as a readout of therapeutic efficacy.
Oncoimmunology
Liechtenstein T,Perez-Janices N,Blanco-Luquin I,Goyvaerts C,Schwarze J,Dufait I,Lanna A,Ridder M,Guerrero-Setas D,Breckpot K,Escors D
12-0042 was used in Flow cytometry/Cell sorting to show that the simultaneous delivery of IL12 and a PD-L1-silencing shRNA exhibits therapeutically relevant anti-tumour activities.
Thu Feb 18 00:00:00 EST 2021
Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface.
PloS one
Habbeddine M,Verbeke P,Karaz S,Bobé P,Kanellopoulos-Langevin C
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Jun 10 00:00:00 EDT 2015
The efficacy of tumor debulking surgery is improved by adjuvant immunotherapy using imiquimod and anti-CD40.
BMC cancer
Khong A,Cleaver AL,Fahmi Alatas M,Wylie BC,Connor T,Fisher SA,Broomfield S,Lesterhuis WJ,Currie AJ,Lake RA,Robinson BW
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Wed Dec 17 00:00:00 EST 2014
P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica.
PloS one
Monção-Ribeiro LC,Faffe DS,Santana PT,Vieira FS,da Graça CL,Marques-da-Silva C,Machado MN,Caruso-Neves C,Zin WA,Borojevic R,Takiya CM,Coutinho-Silva R
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu Sep 17 00:00:00 EDT 2015
Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
Cardiovascular research
Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf.
Oncogene
Baumgartner F,Woess C,Pedit V,Tzankov A,Labi V,Villunger A
12-0042 was used in Flow cytometry/Cell sorting to show that Bad and Bmf co-regulate lymphocyte homeostasis and limit spontaneous transformation in mice.
Thu Jan 31 00:00:00 EST 2013
Inactivation of tumor-specific CD8⁺ CTLs by tumor-infiltrating tolerogenic dendritic cells.
Immunology and cell biology
Harimoto H,Shimizu M,Nakagawa Y,Nakatsuka K,Wakabayashi A,Sakamoto C,Takahashi H
12-0042 was used in Flow cytometry/Cell sorting to investigate cancer immunosurveillance failure caused by the inactivation of CD8+ cytotoxic T lymphocytes by tolerogenic dendritic cells.
Tue Oct 01 00:00:00 EDT 2013
Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.
PloS one
Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Thu Jul 31 00:00:00 EDT 2014
Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells.
PloS one
Xiong H,Maraver A,Latkowski JA,Henderson T,Schlessinger K,Ding Y,Shen J,Tadokoro CE,Lafaille JJ
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Mon Feb 23 00:00:00 EST 2015
Alterations of peripheral CD4+CD25+Foxp3+ T regulatory cells in mice with STZ-induced diabetes.
Cellular & molecular immunology
Zhen Y,Sun L,Liu H,Duan K,Zeng C,Zhang L,Jin D,Peng J,Ding W,Zhao Y
12-0042 was used in Flow cytometry/Cell sorting to investigate the effect of hyperglycemia on CD4+CD25+Tregs, showing alterations of peripheral CD4+CD25+Foxp3+ Tregs in STZ-induced diabetes.
Sun Jan 01 00:00:00 EST 2012
Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice.
Journal of autoimmunity
Tian L,De Hertogh G,Fedeli M,Staats KA,Schonefeldt S,Humblet-Baron S,Van Den Bosch L,Dellabona P,Dooley J,Liston A
12-0042 was used in Flow cytometry/Cell sorting to elucidate the dominant effects of the T cell microRNA expression network and explore it as a potential therapeutic target for autoimmune diseases.
Wed Feb 01 00:00:00 EST 2012
Fates of CD4+ T cells in a tolerant environment depend on timing and place of antigen exposure.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Burrell BE,Bromberg JS
12-0042 was used in Flow cytometry/Cell sorting to elucidate the key factors that determine the fate of graft reactive T cells.
Thu Mar 01 00:00:00 EST 2012
Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Bosmann M,Sarma JV,Atefi G,Zetoune FS,Ward PA
12-0042 was used in Flow cytometry/Cell sorting to demonstrate that C5a alters the production of cytokines to regulate inflammatory functions.
Sun Apr 01 00:00:00 EDT 2012
T cell apoptosis and induction of Foxp3+ regulatory T cells underlie the therapeutic efficacy of CD4 blockade in experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Duarte J,Carrié N,Oliveira VG,Almeida C,Agua-Doce A,Rodrigues L,Simas JP,Mars LT,Graca L
12-0042 was used in Flow cytometry/Cell sorting to investigate the mechanism underlying effective MS prevention, showing that apoptosis of T cells and induction of Foxp3+ Tregs underlie efficacy of CD4 blockade in EAE.
Wed Aug 15 00:00:00 EDT 2012
Staphylococcus aureus induces type I IFN signaling in dendritic cells via TLR9.
Journal of immunology (Baltimore, Md. : 1950)
Parker D,Prince A
12-0042 was used in Flow cytometry/Cell sorting to illustrate an additional mechanism through which S. aureus exploits innate immune signalling to facilitate infection.
Mon Oct 15 00:00:00 EDT 2012
Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model.
Vaccine
Goicochea MA,Zapata JC,Bryant J,Davis H,Salvato MS,Lukashevich IS
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Feb 14 00:00:00 EST 2012
The stalk domain and the glycosylation status of the activating natural killer cell receptor NKp30 are important for ligand binding.
The Journal of biological chemistry
Hartmann J,Tran TV,Kaudeer J,Oberle K,Herrmann J,Quagliano I,Abel T,Cohnen A,Gatterdam V,Jacobs A,Wollscheid B,Tampé R,Watzl C,Diefenbach A,Koch J
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Fri Sep 07 00:00:00 EDT 2012
SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice.
PloS one
Berge T,Grønningsæter IH,Lorvik KB,Abrahamsen G,Granum S,Sundvold-Gjerstad V,Corthay A,Bogen B,Spurkland A
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Tue Aug 26 00:00:00 EDT 2014
Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.
Immunity
Wuerzberger-Davis SM,Chen Y,Yang DT,Kearns JD,Bates PW,Lynch C,Ladell NC,Yu M,Podd A,Zeng H,Huang TT,Wen R,Hoffmann A,Wang D,Miyamoto S
Published figure using CD4 monoclonal antibody (Product # 12-0042-82) in Flow Cytometry
Fri Feb 25 00:00:00 EST 2011
β-Actin specifically controls cell growth, migration, and the G-actin pool.
Molecular biology of the cell
Bunnell TM,Burbach BJ,Shimizu Y,Ervasti JM
12-0042 was used in Flow cytometry/Cell sorting to study the role of beta-actin in cell migration and gene expression.
Tue Nov 01 00:00:00 EDT 2011
Low CD4/CD8 T-cell ratio associated with inflammatory arthropathy in human T-cell leukemia virus type I Tax transgenic mice.
PloS one
Ohsugi T,Kumasaka T
12-0042 was used in Flow cytometry/Cell sorting to identify the primary T-cell subsets involved in the development of arthropathy in Tax transgenic mice.
Fri Apr 01 00:00:00 EDT 2011
Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2.
Blood
Huber S,Hoffmann R,Muskens F,Voehringer D
12-0042 was used in Flow cytometry/Cell sorting to study how IL-4 induced the expression of PD-L2 on CAM, and LPS increased the expression of PD-L1 on alternatively activated macrophages.
Thu Oct 28 00:00:00 EDT 2010
Replication allows inactivation of a knocked-in locus control region in inappropriate cell lineages.
Proceedings of the National Academy of Sciences of the United States of America
Menzel U,Ktistaki E,Tolaini M,Veiga-Fernandes H,Kioussis D
12-0042 was used in Flow cytometry/Cell sorting to explore the effect of a locus control region on a developmentally regulated locus in the mouse CD8 gene complex.
Tue Sep 28 00:00:00 EDT 2010
Resistance to dengue virus infection in mice is potentiated by CXCL10 and is independent of CXCL10-mediated leukocyte recruitment.
Journal of immunology (Baltimore, Md. : 1950)
Ip PP,Liao F
12-0042 was used in Flow cytometry/Cell sorting to study how CXCL10(-/-) mice are more susceptible than wild-type mice to dengue virus infection.
Sat May 15 00:00:00 EDT 2010
Differential geminin requirement for proliferation of thymocytes and mature T cells.
Journal of immunology (Baltimore, Md. : 1950)
Karamitros D,Kotantaki P,Lygerou Z,Veiga-Fernandes H,Pachnis V,Kioussis D,Taraviras S
12-0042 was used in Flow cytometry/Cell sorting to gain insight into the in vivo role of Geminin in progenitor cell division and differentiation.
Mon Mar 01 00:00:00 EST 2010
Tracking epitope-specific T cells.
Nature protocols
Moon JJ,Chu HH,Hataye J,Pagán AJ,Pepper M,McLachlan JB,Zell T,Jenkins MK
12-0042 was used in Flow cytometry/Cell sorting to track epitope-specific T cells.
Tue Jun 30 00:00:00 EDT 2009
IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host.
Journal of immunology (Baltimore, Md. : 1950)
Liu XS,Leerberg J,MacDonald K,Leggatt GR,Frazer IH
12-0042 was used in Flow cytometry/Cell sorting to study the mechanism by which CD8 T cell response is inhibited by CD4(+) T cells in antigen-experienced hosts, showing that IL-10 secretion by CD4(+) cells is enhanced by IFM-gamma signalling, which then inhibits CD8 generation, suggesting that inhibition of IL-10 and IFN-gamma could increase antitumor effect when used in conjunction with antigen immunotherapy.
Wed Jul 01 00:00:00 EDT 2009
IFN-gamma promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host.
Journal of immunology (Baltimore, Md. : 1950)
Liu XS,Leerberg J,MacDonald K,Leggatt GR,Frazer IH
12-0042 was used in Flow cytometry/Cell sorting to study the mechanism by which CD8 T cell response is inhibited by CD4(+) T cells in antigen-experienced hosts, showing that IL-10 secretion by CD4(+) cells is enhanced by IFM-gamma signalling, which then inhibits CD8 generation, suggesting that inhibition of IL-10 and IFN-gamma could increase antitumor effect when used in conjunction with antigen immunotherapy.
Wed Jul 01 00:00:00 EDT 2009
Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut.
Immunity
Tsuji M,Suzuki K,Kitamura H,Maruya M,Kinoshita K,Ivanov II,Itoh K,Littman DR,Fagarasan S
12-0042 was used in Flow cytometry/Cell sorting to investigate the sites and mechanisms for T cell-independent IgA synthesis.
Fri Aug 15 00:00:00 EDT 2008
Endothelial cells support persistent gammaherpesvirus 68 infection.
PLoS pathogens
Suárez AL,van Dyk LF
12-0042 was used in Magnetic cell separation to investigate the role of endothelial cells in gammaherpesvirus 68 infection.
Fri Sep 12 00:00:00 EDT 2008
PDGFRalpha-expressing mesenchyme regulates thymus growth and the availability of intrathymic niches.
Blood
Jenkinson WE,Rossi SW,Parnell SM,Jenkinson EJ,Anderson G
12-0042 was used in Flow cytometry/Cell sorting to study the regulation of thymus growth and the availability of intrathymic niches by pdgfralpha-expressing mesenchyme.
Thu Feb 01 00:00:00 EST 2007
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.
Proceedings of the National Academy of Sciences of the United States of America
Tsuji M,Shinkura R,Kuroda K,Yabe D,Honjo T
12-0042-82 was used in Flow Cytometry to o investigate where and how Notch regulates early T cell differentiation by using specific up-regulation of Notch signaling by Mint knockout.
Tue Jan 30 00:00:00 EST 2007
Immature hematopoietic cells display selective requirements for adhesion- and degranulation-promoting adaptor protein in development and homeostatsis.
European journal of immunology
Dluzniewska J,Zou L,Harmon IR,Ellingson MT,Peterson EJ
12-0042-82 was used in Flow Cytometry to highlight the dynamic regulation of ADAP during T cell maturation and document expression patterns that suggest a possible role for ADAP in development of non-T hematopoietic lineages.
Thu Nov 01 00:00:00 EDT 2007
IL-10 regulates movement of intestinally derived CD4+ T cells to the liver.
Journal of immunology (Baltimore, Md. : 1950)
Bliss SK,Bliss SP,Beiting DP,Alcaraz A,Appleton JA
Fri Jun 15 00:00:00 EDT 2007
Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}.
Proceedings of the National Academy of Sciences of the United States of America
Rubinstein MP,Kovar M,Purton JF,Cho JH,Boyman O,Surh CD,Sprent J
Tue Jun 13 00:00:00 EDT 2006
Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes.
Immunity
Sato T,Ohno S,Hayashi T,Sato C,Kohu K,Satake M,Habu S
12-0042 was used in Flow cytometry/Cell sorting to investigate the involvement of Runx proteins in the lineage specification of CD8 T cells.
Tue Mar 01 00:00:00 EST 2005
T/B lineage choice occurs prior to intrathymic Notch signaling.
Blood
Harman BC,Jenkinson WE,Parnell SM,Rossi SW,Jenkinson EJ,Anderson G
12-0042 was used in Flow cytometry/Cell sorting to analyse the T-cell/B-cell lineage potential of precursors that have been recruited to the foetal mouse thymus, showing that lineage choice occurs prior to intrathymic Notch signaling.
Mon Aug 01 00:00:00 EDT 2005
