Product References
Impact of broad-spectrum antibiotics on the gut-microbiota-spleen-brain axis.
Brain, behavior, & immunity - health
Wan X,Eguchi A,Sakamoto A,Fujita Y,Yang Y,Qu Y,Hatano M,Mori C,Hashimoto K
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2023
Impact of broad-spectrum antibiotics on the gut-microbiota-spleen-brain axis.
Brain, behavior, & immunity - health
Wan X,Eguchi A,Sakamoto A,Fujita Y,Yang Y,Qu Y,Hatano M,Mori C,Hashimoto K
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2023
Klebsiella pneumoniae Induces Inflammatory Bowel Disease Through Caspase-11-Mediated IL18 in the Gut Epithelial Cells.
Cellular and molecular gastroenterology and hepatology
Zhang Q,Su X,Zhang C,Chen W,Wang Y,Yang X,Liu D,Zhang Y,Yang R
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Thu Feb 23 00:00:00 EST 2023
Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function.
British journal of pharmacology
Liao W,Foo HYC,Tran TNQ,Chai CLL,Wong WSF
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2023
Palmitoyl transferases act as novel drug targets for pancreatic cancer.
Journal of translational medicine
Lin Z,Lv Z,Liu X,Huang K
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon Apr 10 00:00:00 EDT 2023
SARS-CoV-2 spike protein promotes inflammatory cytokine activation and aggravates rheumatoid arthritis.
Cell communication and signaling : CCS
Lee AR,Woo JS,Lee SY,Lee YS,Jung J,Lee CR,Park SH,Cho ML
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Thu Mar 02 00:00:00 EST 2023
TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.
Frontiers in immunology
O'Neill TJ,Gewies A,Seeholzer T,Krappmann D
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon Feb 13 00:00:00 EST 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2023
Meningeal lymphatics regulate radiotherapy efficacy through modulating anti-tumor immunity.
Cell research
Zhou C,Ma L,Xu H,Huo Y,Luo J
17-0042-82 was used in Flow Cytometry to suggest an essential role of the MLV-CLN network in RT-triggered anti-tumor immunity, and highlight the potential of VEGF-C mRNA for brain tumor therapy.
Wed Jun 01 00:00:00 EDT 2022
Aryl hydrocarbon receptor activation ameliorates experimental colitis by modulating the tolerogenic dendritic and regulatory T cell formation.
Cell & bioscience
Cui X,Ye Z,Wang D,Yang Y,Jiao C,Ma J,Tang N,Zhang H
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Sat Apr 23 00:00:00 EDT 2022
IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection.
Nature communications
Xu L,Wei C,Chen Y,Wu Y,Shou X,Chen W,Lu D,Sun H,Li W,Yu B,Wang X,Zhang X,Yu Y,Lei Z,Tang R,Zhu J,Li Y,Lu L,Zhou H,Zhou S,Su C,Chen X
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Sat Nov 12 00:00:00 EST 2022
Fringe GlcNAc-transferases differentially extend O-fucose on endogenous NOTCH1 in mouse activated T cells.
The Journal of biological chemistry
Matsumoto K,Kumar V,Varshney S,Nairn AV,Ito A,Pennarubia F,Moremen KW,Stanley P,Haltiwanger RS
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Fri Jul 01 00:00:00 EDT 2022
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling.
Nature communications
Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2022
A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts.
Immunity
Zindl CL,Witte SJ,Laufer VA,Gao M,Yue Z,Janowski KM,Cai B,Frey BF,Silberger DJ,Harbour SN,Singer JR,Turner H,Lund FE,Vallance BA,Rosenberg AF,Schoeb TR,Chen JY,Hatton RD,Weaver CT
17-0042-82 was used in Flow cytometry/Cell sorting to demonstrate spatiotemporal differences in the production and action of IL-22 by ILCs and T cells during infection and reveal an indispensable role for IL-22-producing T cells in the protection of the intestinal crypts.
Tue Mar 08 00:00:00 EST 2022
Foxo3a tempers excessive glutaminolysis in activated T cells to prevent fatal gut inflammation in the murine IL-10-/- model of colitis.
Cell death and differentiation
Hajjar S,Nathan N,Joseph J,Mottawea W,Ariana A,Pyatibrat S,Harper ME,Alain T,Blais A,Russell RC,Sad S
17-0042-82 was used in Flow cytometry/Cell sorting to show that Foxo3a restricts the abundance of colitogenic microbiota in IL-10-deficient mice.
Tue Mar 01 00:00:00 EST 2022
Induction of osteogenesis by bone-targeted Notch activation.
eLife
Xu C,Dinh VV,Kruse K,Jeong HW,Watson EC,Adams S,Berkenfeld F,Stehling M,Rasouli SJ,Fan R,Chen R,Bedzhov I,Chen Q,Kato K,Pitulescu ME,Adams RH
17-0042-82 was used in Flow Cytometry to propose that activation of Notch signaling by bone-targeted fusion proteins might be therapeutically useful and can avoid detrimental effects in Notch-dependent processes in other organs.
Fri Feb 04 00:00:00 EST 2022
Axl regulated survival/proliferation network and its therapeutic intervention in mouse models of glomerulonephritis.
Arthritis research & therapy
Zhen Y,Ren Y,Medvedovic M,Adams DE,Wang D,Shao WH
17-0042-82 was used in Immunohistochemistry (Frozen) to analyze the gene expression profiles with RNA-seq using renal cortical samples from nephritic mice.
Wed Dec 28 00:00:00 EST 2022
Loss of Optineurin Drives Cancer Immune Evasion via Palmitoylation-Dependent IFNGR1 Lysosomal Sorting and Degradation.
Cancer discovery
Du W,Hua F,Li X,Zhang J,Li S,Wang W,Zhou J,Wang W,Liao P,Yan Y,Li G,Wei S,Grove S,Vatan L,Zgodziński W,Majewski M,Wallner G,Chen H,Kryczek I,Fang JY,Zou W
17-0042-82 was used in Flow Cytometry to show that optineurin is a shared node between the IFN and MHC pathways and predicts colorectal cancer patient outcome.
Thu Jul 01 00:00:00 EDT 2021
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Unexpected PD-L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies.
EMBO molecular medicine
Mondal T,Shivange GN,Tihagam RG,Lyerly E,Battista M,Talwar D,Mosavian R,Urbanek K,Rashid NS,Harrell JC,Bos PD,Stelow EB,Stack MS,Bhatnagar S,Tushir-Singh J
17-0042-82 was used in Flow Cytometry to identify a potential clinically viable combinatorial strategy to revive solid cancer immunotherapy using death receptor agonism.
Fri Mar 05 00:00:00 EST 2021
Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer.
Cancer immunology, immunotherapy : CII
Shi Y,Fu Y,Zhang X,Zhao G,Yao Y,Guo Y,Ma G,Bai S,Li H
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Potential therapeutic effects of interleukin-35 on the differentiation of naïve T cells into Helios+Foxp3+ Tregs in clinical and experimental acute respiratory distress syndrome.
Molecular immunology
Wang C,Xie K,Li K,Lin S,Xu F
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
Anisakis pegreffii Extract Induces Airway Inflammation with Airway Remodeling in a Murine Model System.
BioMed research international
Choi JH,Kim JY,Yi MH,Kim M,Yong TS
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Jan 12 00:00:00 EST 2022
Anisakis pegreffii Extract Induces Airway Inflammation with Airway Remodeling in a Murine Model System.
BioMed research international
Choi JH,Kim JY,Yi MH,Kim M,Yong TS
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Jan 12 00:00:00 EST 2022
Feline adipose tissue-derived mesenchymal stem cells pretreated with IFN-γ enhance immunomodulatory effects through the PGE₂ pathway.
Journal of veterinary science
Park SG,An JH,Li Q,Chae HK,Park SM,Lee JH,Ahn JO,Song WJ,Youn HY
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon Mar 01 00:00:00 EST 2021
Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.
The Journal of international medical research
Li W,Luo Y,Xu H,Ma Q,Yao Q
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation.
Theranostics
Chen L,Chen H,Ye J,Ge Y,Wang H,Dai E,Ren J,Liu W,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
17-0042-82 was used in Flow Cytometry to explore the use of virally-delivered interleukin 23 as an anti-cancer treatment.
Wed Aug 04 00:00:00 EDT 2021
Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation.
Theranostics
Chen L,Chen H,Ye J,Ge Y,Wang H,Dai E,Ren J,Liu W,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
17-0042-82 was used in Flow Cytometry to explore the use of virally-delivered interleukin 23 as an anti-cancer treatment.
Wed Aug 04 00:00:00 EDT 2021
Antitumor efficacy of a neoantigen cancer vaccine delivered by electroporation is influenced by microbiota composition.
Oncoimmunology
Lione L,Salvatori E,Petrazzuolo A,Massacci A,Maggio R,Confroti A,Compagnone M,Aurisicchio L,Ciliberto G,Palombo F
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Mar 23 00:00:00 EDT 2021
Evaluation of DNA-Launched Virus-Like Particle Vaccines in an Immune Competent Mouse Model of Chikungunya Virus Infection.
Vaccines
Rayner JO,Kim JH,Roberts RW,Wood RR,Fouty B,Solodushko V
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Fri Apr 02 00:00:00 EDT 2021
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon Dec 20 00:00:00 EST 2021
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon Dec 20 00:00:00 EST 2021
Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in Mice.
Frontiers in microbiology
Yu X,Zhou G,Shao B,Zhou H,Xu C,Yan F,Wang L,Chen G,Li J,Fu X
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed May 26 00:00:00 EDT 2021
Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.
EBioMedicine
Okada R,Furusawa A,Vermeer DW,Inagaki F,Wakiyama H,Kato T,Nagaya T,Choyke PL,Spanos WC,Allen CT,Kobayashi H
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Activation of Bone Marrow Adaptive Immunity in Type 2 Diabetes: Rescue by Co-stimulation Modulator Abatacept.
Frontiers in immunology
Santopaolo M,Sullivan N,Thomas AC,Alvino VV,Nicholson LB,Gu Y,Spinetti G,Kallikourdis M,Blom A,Madeddu P
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Fri Jul 02 00:00:00 EDT 2021
Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer.
Nature communications
Huang Y,Guan Z,Dai X,Shen Y,Wei Q,Ren L,Jiang J,Xiao Z,Jiang Y,Liu D,Huang Z,Xu X,Luo Y,Zhao C
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Jul 14 00:00:00 EDT 2021
Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE-/- mice in the presence and absence of immunomodulation with fingolimod.
Data in brief
Diaz Diaz AC,Malone K,Shearer JA,Moore AC,Waeber C
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Jun 01 00:00:00 EDT 2021
Local Sustained GM-CSF Delivery by Genetically Engineered Encapsulated Cells Enhanced Both Cellular and Humoral SARS-CoV-2 Spike-Specific Immune Response in an Experimental Murine Spike DNA Vaccination Model.
Vaccines
Vernet R,Charrier E,Cosset E,Fièvre S,Tomasello U,Grogg J,Mach N
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon May 10 00:00:00 EDT 2021
Sequencing, cloning, and antigen binding analysis of monoclonal antibodies isolated from single mouse B cells.
STAR protocols
Viant C,Escolano A,Chen ST,Nussenzweig MC
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Fri Jun 18 00:00:00 EDT 2021
Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis.
Journal of neuroinflammation
Chen YH,Eskandarpour M,Zhang X,Galatowicz G,Greenwood J,Lightman S,Calder V
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Thu Feb 18 00:00:00 EST 2021
Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.
STAR protocols
Skordos I,Demeyer A,Beyaert R
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Fri Mar 19 00:00:00 EDT 2021
STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer.
Journal for immunotherapy of cancer
Lee SJ,Yang H,Kim WR,Lee YS,Lee WS,Kong SJ,Lee HJ,Kim JH,Cheon J,Kang B,Chon HJ,Kim C
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Jun 01 00:00:00 EDT 2021
Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.
PloS one
Cohen AA,Yang Z,Gnanapragasam PNP,Ou S,Dam KA,Wang H,Bjorkman PJ
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Fri Oct 15 00:00:00 EDT 2021
A dysbiotic gut microbiome suppresses antibody mediated-protection against Vibrio cholerae.
iScience
Macbeth JC,Liu R,Alavi S,Hsiao A
17-0042-82 was used in Flow cytometry/Cell sorting to suggest that gut microbiome composition at time of infection or vaccination may be pivotal for providing robust mucosal immunity, and suggest a target for improved prophylactic and therapeutic strategies for cholera.
Fri Dec 17 00:00:00 EST 2021
Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency.
Cell stem cell
Liang R,Arif T,Kalmykova S,Kasianov A,Lin M,Menon V,Qiu J,Bernitz JM,Moore K,Lin F,Benson DL,Tzavaras N,Mahajan M,Papatsenko D,Ghaffari S
17-0042-82 was used in Flow Cytometry to investigate the overall metabolic properties of hematopoietic stem cells.
Thu Mar 05 00:00:00 EST 2020
Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.
The Journal of clinical investigation
Webb LM,Sengupta S,Edell C,Piedra-Quintero ZL,Amici SA,Miranda JN,Bevins M,Kennemer A,Laliotis G,Tsichlis PN,Guerau-de-Arellano M
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Long-term ex vivo expansion of mouse hematopoietic stem cells.
Nature protocols
Wilkinson AC,Ishida R,Nakauchi H,Yamazaki S
17-0042 was used in Flow cytometry/Cell sorting to describe a simple platform for the expansion of functional mouse hematopoietic stem cells ex vivo for >1 month under fully defined albumin-free conditions.
Sat Feb 01 00:00:00 EST 2020
Methnaridine is an orally bioavailable, fast-killing and long-acting antimalarial agent that cures Plasmodium infections in mice.
British journal of pharmacology
Wang W,Yao J,Chen Z,Sun Y,Shi Y,Wei Y,Zhou H,Yu Y,Li S,Duan L
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2020
DKK2 blockage-mediated immunotherapy enhances anti-angiogenic therapy of Kras mutated colorectal cancer.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Hu J,Wang Z,Chen Z,Li A,Sun J,Zheng M,Wu J,Shen T,Qiao J,Li L,Li B,Wu D,Xiao Q
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Jul 01 00:00:00 EDT 2020
Increased Tim-3 expression on TILs during treatment with the Anchored GM-CSF vaccine and anti-PD-1 antibodies is inversely correlated with response in prostate cancer.
Journal of Cancer
Zhang X,Chen H,Li G,Zhou X,Shi Y,Zou F,Chen Y,Gao J,Yang S,Wu S,Long Z
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Sep 30 00:00:00 EDT 2020
Comparison of rapamycin and methylprednisolone for treating inflammatory muscle disease in a murine model of experimental autoimmune myositis.
Experimental and therapeutic medicine
Kang J,Feng D,Yang F,Tian X,Han W,Jia H
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Jul 01 00:00:00 EDT 2020
Effects of CD4+ T lymphocytes from ovariectomized mice on bone marrow mesenchymal stem cell proliferation and osteogenic differentiation.
Experimental and therapeutic medicine
Shao BY,Wang L,Yu Y,Chen L,Gan N,Huang WM
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2020
Effects of CD4+ T lymphocytes from ovariectomized mice on bone marrow mesenchymal stem cell proliferation and osteogenic differentiation.
Experimental and therapeutic medicine
Shao BY,Wang L,Yu Y,Chen L,Gan N,Huang WM
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Thu Sep 17 00:00:00 EDT 2020
Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety.
Journal for immunotherapy of cancer
Ge Y,Wang H,Ren J,Liu W,Chen L,Chen H,Ye J,Dai E,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
17-0042-82 was used in Flow Cytometry to show IL-12 tethered to oncolytic vaccinia virus leading to transformed, immunogenic tumors and improved survival.
Sun Mar 01 00:00:00 EST 2020
Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety.
Journal for immunotherapy of cancer
Ge Y,Wang H,Ren J,Liu W,Chen L,Chen H,Ye J,Dai E,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL
17-0042-82 was used in Flow Cytometry to show IL-12 tethered to oncolytic vaccinia virus leading to transformed, immunogenic tumors and improved survival.
Sun Mar 01 00:00:00 EST 2020
A novel antibody targeting TIM-3 resulting in receptor internalization for cancer immunotherapy.
Antibody therapeutics
Kuang Z,Li L,Zhang P,Chen B,Wu M,Ni H,Yi S,Zou J,Liu J
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2020
Mechanisms of interleukin 4 mediated increase in efficacy of vaccines against opioid use disorders.
NPJ vaccines
Crouse B,Robinson C,Huseby Kelcher A,Laudenbach M,Abrahante JE,Pravetoni M
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Thu Oct 29 00:00:00 EDT 2020
CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.
Frontiers in immunology
Shapiro MR,Yeh WI,Longfield JR,Gallagher J,Infante CM,Wellford S,Posgai AL,Atkinson MA,Campbell-Thompson M,Lieberman SM,Serreze DV,Geurts AM,Chen YG,Brusko TM
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed May 26 00:00:00 EDT 2021
Distinct actions of the fermented beverage kefir on host behaviour, immunity and microbiome gut-brain modules in the mouse.
Microbiome
van de Wouw M,Walsh AM,Crispie F,van Leuven L,Lyte JM,Boehme M,Clarke G,Dinan TG,Cotter PD,Cryan JF
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon May 18 00:00:00 EDT 2020
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.
Nature communications
Iske J,Seyda M,Heinbokel T,Maenosono R,Minami K,Nian Y,Quante M,Falk CS,Azuma H,Martin F,Passos JF,Niemann CU,Tchkonia T,Kirkland JL,Elkhal A,Tullius SG
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Thu Aug 27 00:00:00 EDT 2020
Loss of testosterone impairs anti-tumor neutrophil function.
Nature communications
Markman JL,Porritt RA,Wakita D,Lane ME,Martinon D,Noval Rivas M,Luu M,Posadas EM,Crother TR,Arditi M
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Mar 31 00:00:00 EDT 2020
Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.
Cell reports
Blagih J,Zani F,Chakravarty P,Hennequart M,Pilley S,Hobor S,Hock AK,Walton JB,Morton JP,Gronroos E,Mason S,Yang M,McNeish I,Swanton C,Blyth K,Vousden KH
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Jan 14 00:00:00 EST 2020
Cancer-Specific Loss of p53 Leads to a Modulation of Myeloid and T Cell Responses.
Cell reports
Blagih J,Zani F,Chakravarty P,Hennequart M,Pilley S,Hobor S,Hock AK,Walton JB,Morton JP,Gronroos E,Mason S,Yang M,McNeish I,Swanton C,Blyth K,Vousden KH
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Jan 14 00:00:00 EST 2020
TIAM2S Mediates Serotonin Homeostasis and Provokes a Pro-Inflammatory Immune Microenvironment Permissive for Colorectal Tumorigenesis.
Cancers
Chan YL,Lai WC,Chen JS,Tseng JT,Chuang PC,Jou J,Lee CT,Sun HS
17-0042 was used in Flow cytometry/Cell sorting to suggest that TIAM2S provokes a pro-inflammatory immune microenvironment permissive to colorectal tumorigenesis through the serotonin-induced immunomodulatory effects.
Wed Jul 08 00:00:00 EDT 2020
KLF10 Deficiency in CD4+ T Cells Triggers Obesity, Insulin Resistance, and Fatty Liver.
Cell reports
Wara AK,Wang S,Wu C,Fang F,Haemmig S,Weber BN,Aydogan CO,Tesmenitsky Y,Aliakbarian H,Hawse JR,Subramaniam M,Zhao L,Sage PT,Tavakkoli A,Garza A,Lynch L,Banks AS,Feinberg MW
17-0042-82 was used in Flow Cytometry to explore the role of KLF10 in high-fat-diet-induced obesity and insulin resistance.
Tue Dec 29 00:00:00 EST 2020
A Commercial Probiotic Induces Tolerogenic and Reduces Pathogenic Responses in Experimental Autoimmune Encephalomyelitis.
Cells
Calvo-Barreiro L,Eixarch H,Ponce-Alonso M,Castillo M,Lebrón-Galán R,Mestre L,Guaza C,Clemente D,Del Campo R,Montalban X,Espejo C
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Apr 07 00:00:00 EDT 2020
Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells.
Cell reports
Shin B,Benavides GA,Geng J,Koralov SB,Hu H,Darley-Usmar VM,Harrington LE
17-0042 was used in Flow cytometry/Cell sorting to study the role of mitochondrial oxidative phosphorylation in pathogenic Th17 differentiation.
Tue Feb 11 00:00:00 EST 2020
Resolving Fates and Single-Cell Transcriptomes of Hematopoietic Stem Cell Clones by PolyloxExpress Barcoding.
Cell stem cell
Pei W,Shang F,Wang X,Fanti AK,Greco A,Busch K,Klapproth K,Zhang Q,Quedenau C,Sauer S,Feyerabend TB,Höfer T,Rodewald HR
17-0042 was used in Flow cytometry/Cell sorting to develop the PolyloxExpress allele, enabling Cre-recombinase-dependent RNA barcoding in situ.
Thu Sep 03 00:00:00 EDT 2020
Axenic Caenorhabditis elegans antigen protects against development of type-1 diabetes in NOD mice.
Journal of translational autoimmunity
Jackson-Thompson BM,Torrero M,Mitre BK,Long J,Packiam M,Mitre E
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon Sep 28 00:00:00 EDT 2020
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.
Nature
Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S
17-0042 was used in Flow cytometry/Cell sorting to identify polyvinyl alcohol as a functionally superior replacement for serum albumin that is compatible with good manufacturing practice.
Mon Jul 01 00:00:00 EDT 2019
The cis-Regulatory Atlas of the Mouse Immune System.
Cell
Yoshida H,Lareau CA,Ramirez RN,Rose SA,Maier B,Wroblewska A,Desland F,Chudnovskiy A,Mortha A,Dominguez C,Tellier J,Kim E,Dwyer D,Shinton S,Nabekura T,Qi Y,Yu B,Robinette M,Kim KW,Wagers A,Rhoads A,Nutt SL,Brown BD,Mostafavi S,Buenrostro JD,Benoist C
17-0042-82 was used in Flow Cytometry to generate matched epigenome and transcriptome measurements in 86 primary cell types that span the mouse immune system and its differentiation cascade.
Thu Feb 07 00:00:00 EST 2019
Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice.
Genome research
Alriyami M,Marchand L,Li Q,Du X,Olivier M,Polychronakos C
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Sun Dec 01 00:00:00 EST 2019
Podoplanin Positive Myeloid Cells Promote Glioma Development by Immune Suppression.
Frontiers in oncology
Eisemann T,Costa B,Peterziel H,Angel P
17-0042 was used in Flow cytometry/Cell sorting to identify the role of podoplanin positive myeloid cells in immune suppression and thus their potential as a target for immune mediated tumour elimination.
Wed Sep 30 00:00:00 EDT 2020
A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia.
JCI insight
Yin M,Baslan T,Walker RL,Zhu YJ,Freeland A,Matsukawa T,Sridharan S,Nussenzweig A,Pruitt SC,Lowe SW,Meltzer PS,Aplan PD
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Thu Dec 05 00:00:00 EST 2019
Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction.
Frontiers in immunology
Fenninger F,Han J,Stanwood SR,Nohara LL,Arora H,Choi KB,Munro L,Pfeifer CG,Shanina I,Horwitz MS,Jefferies WA
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Thu Oct 29 00:00:00 EDT 2020
Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis.
Scientific reports
Brichacek AL,Benkovic SA,Chakraborty S,Nwafor DC,Wang W,Jun S,Dakhlallah D,Geldenhuys WJ,Pinkerton AB,Millán JL,Brown CM
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Dec 11 00:00:00 EST 2019
Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR.
Nature communications
Zhu H,Bhatt B,Sivaprakasam S,Cai Y,Liu S,Kodeboyina SK,Patel N,Savage NM,Sharma A,Kaufman RJ,Li H,Singh N
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Mar 06 00:00:00 EST 2019
Carbon ion irradiation enhances the antitumor efficacy of dual immune checkpoint blockade therapy both for local and distant sites in murine osteosarcoma.
Oncotarget
Takahashi Y,Yasui T,Minami K,Tamari K,Hayashi K,Otani K,Seo Y,Isohashi F,Koizumi M,Ogawa K
17-0042 was used in Flow cytometry/Cell sorting to understand the efficacy of combining carbon ion irradiation and dual immune checkpoint blockade therapy to treat local and distant sites in osteosarcoma in mice.
Fri Jan 18 00:00:00 EST 2019
The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells.
Cell reports
Araujo LP,Maricato JT,Guereschi MG,Takenaka MC,Nascimento VM,de Melo FM,Quintana FJ,Brum PC,Basso AS
17-0042-82 was used in Flow Cytometry to uncover a suppressive role for the SNS in CNS autoimmunity while they identify potential targets for therapeutic intervention.
Tue Sep 17 00:00:00 EDT 2019
Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases.
Scientific reports
Park TY,Jang Y,Kim W,Shin J,Toh HT,Kim CH,Yoon HS,Leblanc P,Kim KS
17-0042 was used in Flow cytometry/Cell sorting to show the orphan nuclear receptor Nurr1 mediates Foxp3 expression and differentiation of TREG cells leading to symptoms of inflammatory bowel disease.
Tue Oct 29 00:00:00 EDT 2019
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.
Nature communications
Sasaki K,Himeno A,Nakagawa T,Sasaki Y,Kiyonari H,Iwai K
17-0042-82 was used in Flow Cytometry to show that T cell-mediated killing and sequential autoinflammation are common and crucial for pathogenic diversity during T cell-mediated autoimmune responses.
Wed Aug 28 00:00:00 EDT 2019
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Thu Jun 28 00:00:00 EDT 2018
T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation.
Immunity
Shimada K,Porritt RA,Markman JL,O'Rourke JG,Wakita D,Noval Rivas M,Ogawa C,Kozhaya L,Martins GA,Unutmaz D,Baloh RH,Crother TR,Chen S,Arditi M
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Nov 20 00:00:00 EST 2018
TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4+CD8+ thymocytes.
Nature immunology
Emmanuel AO,Arnovitz S,Haghi L,Mathur PS,Mondal S,Quandt J,Okoreeh MK,Maienschein-Cline M,Khazaie K,Dose M,Gounari F
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Sat Dec 01 00:00:00 EST 2018
Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.
Cell stem cell
Yamamoto R,Wilkinson AC,Ooehara J,Lan X,Lai CY,Nakauchi Y,Pritchard JK,Nakauchi H
17-0042 was used in Flow cytometry/Cell sorting to determine the age-related functional changes to the haematopoietic stem cell compartment.
Thu Apr 05 00:00:00 EDT 2018
Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5.
The Journal of experimental medicine
Buxadé M,Huerga Encabo H,Riera-Borrull M,Quintana-Gallardo L,López-Cotarelo P,Tellechea M,Martínez-Martínez S,Redondo JM,Martín-Caballero J,Flores JM,Bosch E,Rodríguez-Fernández JL,Aramburu J,López-Rodríguez C
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon Nov 05 00:00:00 EST 2018
Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection.
The Journal of experimental medicine
Nair S,Huynh JP,Lampropoulou V,Loginicheva E,Esaulova E,Gounder AP,Boon ACM,Schwarzkopf EA,Bradstreet TR,Edelson BT,Artyomov MN,Stallings CL,Diamond MS
17-0042 was used in Flow cytometry/Cell sorting to study the role of Immune responsive gene 1 in the modulation of inflammation during Mycobacterium tuberculosis infection.
Mon Apr 02 00:00:00 EDT 2018
Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation.
The Journal of experimental medicine
Shin B,Kress RL,Kramer PA,Darley-Usmar VM,Bellis SL,Harrington LE
17-0042 was used in Flow cytometry/Cell sorting to indicate that the chronicity of T cell-mediated inflammation is perpetuated by specific effector CD4 T cells with stem-like properties.
Mon Jul 02 00:00:00 EDT 2018
In Vitro Priming of Adoptively Transferred T Cells with a RORγ Agonist Confers Durable Memory and Stemness In Vivo.
Cancer research
Hu X,Majchrzak K,Liu X,Wyatt MM,Spooner CJ,Moisan J,Zou W,Carter LL,Paulos CM
17-0042 was used in Flow cytometry/Cell sorting to demonstrate that addition of a synthetic, small-molecule RORγ agonist during ex vivo expansion potentiates the anti-tumour activity of human Th17 and Tc17 cells redirected with a chimeric antigen receptor.
Sun Jul 15 00:00:00 EDT 2018
Bryostatin-1 alleviates experimental multiple sclerosis.
Proceedings of the National Academy of Sciences of the United States of America
Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Feb 27 00:00:00 EST 2018
Quantitative Methods for Measuring Repair Rates and Innate-Immune Cell Responses in Wounded Mouse Skin.
Frontiers in immunology
Li Z,Gothard E,Coles MC,Ambler CA
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Mar 27 00:00:00 EDT 2019
Lenalidomide and Programmed Death-1 Blockade Synergistically Enhances the Effects of Dendritic Cell Vaccination in a Model of Murine Myeloma.
Frontiers in immunology
Vo MC,Jung SH,Chu TH,Lee HJ,Lakshmi TJ,Park HS,Kim HJ,Rhee JH,Lee JJ
17-0042 was used in Flow cytometry/Cell sorting to investigate the efficacy of dendritic cell vaccination in combination with lenalidomide and PD-1 blockade in a model of murine myeloma.
Sun Jan 03 00:00:00 EST 2021
Protease-activated receptor-2 signaling through β-arrestin-2 mediates Alternaria alkaline serine protease-induced airway inflammation.
American journal of physiology. Lung cellular and molecular physiology
Yee MC,Nichols HL,Polley D,Saifeddine M,Pal K,Lee K,Wilson EH,Daines MO,Hollenberg MD,Boitano S,DeFea KA
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Sat Dec 01 00:00:00 EST 2018
Intraperitoneal neutrophils activated by KRAS-induced ovarian cancer exert antitumor effects by modulating adaptive immunity.
International journal of oncology
Yoshida M,Taguchi A,Kawana K,Ogishima J,Adachi K,Kawata A,Nakamura H,Sato M,Fujimoto A,Inoue T,Tomio K,Mori M,Nagamatsu T,Arimoto T,Koga K,Hiraike OW,Oda K,Kiyono T,Osuga Y,Fujii T
17-0042 was used in Flow cytometry/Cell sorting to evaluate the role of increased neutrophils in cancer progression.
Mon Oct 01 00:00:00 EDT 2018
Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice.
Journal of neuroimmunology
Kiyota T,Machhi J,Lu Y,Dyavarshetty B,Nemati M,Yokoyama I,Mosley RL,Gendelman HE
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Fri Jun 15 00:00:00 EDT 2018
Immunological effects of a low-dose cytarabine, aclarubicin and granulocyte-colony stimulating factor priming regimen on a mouse leukemia model.
Oncology letters
Chen J,Yang N,Liu H,Yao H,Wang J,Yang Y,Zhang W
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
Protective function of Bu Shen Huo Xue formula on the immunity of B6AF1 mice with experimental autoimmune premature ovarian failure.
Experimental and therapeutic medicine
Wang P,Lu Y,Chen S,Chen Y,Hu C,Zuo Y
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2018
Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene.
Nature communications
Kojo S,Yasmin N,Muroi S,Tenno M,Taniuchi I
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Sep 05 00:00:00 EDT 2018
Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.
Nature communications
Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Thu Nov 08 00:00:00 EST 2018
Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation.
Cell death & disease
Ding Y,Liang X,Zhang Y,Yi L,Shum HC,Chen Q,Chan BP,Fan H,Liu Z,Tergaonkar V,Qi Z,Tse HF,Lian Q
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Mar 07 00:00:00 EST 2018
Inactivation of TRPM7 kinase in mice results in enlarged spleens, reduced T-cell proliferation and diminished store-operated calcium entry.
Scientific reports
Beesetty P,Wieczerzak KB,Gibson JN,Kaitsuka T,Luu CT,Matsushita M,Kozak JA
17-0042 was used in Flow cytometry/Cell sorting to study the role of TRPM7 channel kinase as a novel modulator of blastogenesis, proliferation and store-operated calcium entry.
Wed Feb 14 00:00:00 EST 2018
Fundamental parameters of the developing thymic epithelium in the mouse.
Scientific reports
Hirakawa M,Nagakubo D,Kanzler B,Avilov S,Krauth B,Happe C,Swann JB,Nusser A,Boehm T
17-0042 was used in Flow cytometry/Cell sorting to study the dynamic of thymic epithelial cells and thymocytes during embryogenesis.
Mon Jul 23 00:00:00 EDT 2018
NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation.
Nature communications
Brosseau JP,Liao CP,Wang Y,Ramani V,Vandergriff T,Lee M,Patel A,Ariizumi K,Le LQ
17-0042 was used in Flow cytometry/Cell sorting to study the role of the neurofibromatosis type 1 tumour suppressor gene in de novo tumorigenesis and malignant transformation.
Tue Nov 27 00:00:00 EST 2018
Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation.
Scientific reports
Chen EW,Brzostek J,Gascoigne NRJ,Rybakin V
Tue Jul 03 00:00:00 EDT 2018
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias.
Nature communications
Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K
17-0042 was used in Flow cytometry/Cell sorting to study paediatric acute myeloid leukaemia biology, and provide murine models that offer the potential for developing paediatric specific therapeutic strategies.
Tue Dec 11 00:00:00 EST 2018
CCR8 is expressed by post-positive selection CD4-lineage thymocytes but is dispensable for central tolerance induction.
PloS one
Thyagarajan HM,Lancaster JN,Lira SA,Ehrlich LIR
17-0042 was used in flow-cytometry to investigate whether chemokine receptor CCR8 promotes thymocyte medullary entry and/or rapid motility to induce negative selection.
Tue Jan 22 00:00:00 EST 2019
Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response.
Gut
Blasco-Baque V,Garidou L,Pomié C,Escoula Q,Loubieres P,Le Gall-David S,Lemaitre M,Nicolas S,Klopp P,Waget A,Azalbert V,Colom A,Bonnaure-Mallet M,Kemoun P,Serino M,Burcelin R
17-0042 was used in Flow cytometry/Cell sorting to determine the causal mechanism responsible for the enhancement of hyperglycemia and insulin resistance in mice fed a fat-enriched diet.
Mon May 01 00:00:00 EDT 2017
Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment.
The Journal of clinical investigation
Wang YT,Chen J,Chang CW,Jen J,Huang TY,Chen CM,Shen R,Liang SY,Cheng IC,Yang SC,Lai WW,Cheng KH,Hsieh TS,Lai MZ,Cheng HC,Wang YC,Chen RH
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2017
Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.
The Journal of clinical investigation
Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression.
Molecular cell
Ren G,Jin W,Cui K,Rodrigez J,Hu G,Zhang Z,Larson DR,Zhao K
17-0042 was used in Flow cytometry/Cell sorting to study the role of CTCF in regulating cell-to-cell variation of expression.
Thu Sep 21 00:00:00 EDT 2017
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
The Journal of experimental medicine
Schwartz C,Khan AR,Floudas A,Saunders SP,Hams E,Rodewald HR,McKenzie ANJ,Fallon PG
17-0042 was used in Flow cytometry/Cell sorting to study how group 2 innate lymphoid cells regulate adaptive Th2 cell functions.
Mon Sep 04 00:00:00 EDT 2017
IL-36 Signaling Facilitates Activation of the NLRP3 Inflammasome and IL-23/IL-17 Axis in Renal Inflammation and Fibrosis.
Journal of the American Society of Nephrology : JASN
Chi HH,Hua KF,Lin YC,Chu CL,Hsieh CY,Hsu YJ,Ka SM,Tsai YL,Liu FC,Chen A
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Sat Jul 01 00:00:00 EDT 2017
IL-36 Signaling Facilitates Activation of the NLRP3 Inflammasome and IL-23/IL-17 Axis in Renal Inflammation and Fibrosis.
Journal of the American Society of Nephrology : JASN
Chi HH,Hua KF,Lin YC,Chu CL,Hsieh CY,Hsu YJ,Ka SM,Tsai YL,Liu FC,Chen A
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Sat Jul 01 00:00:00 EDT 2017
Intestinal Batf3-dependent dendritic cells are required for optimal antiviral T-cell responses in adult and neonatal mice.
Mucosal immunology
Sun T,Rojas OL,Li C,Ward LA,Philpott DJ,Gommerman JL
17-0042 was used in Flow cytometry/Cell sorting to study the dendritic cell subset(s) that provoke antiviral responses within the gut.
Mon May 01 00:00:00 EDT 2017
Subunit vaccine H56/CAF01 induces a population of circulating CD4 T cells that traffic into the Mycobacterium tuberculosis-infected lung.
Mucosal immunology
Woodworth JS,Cohen SB,Moguche AO,Plumlee CR,Agger EM,Urdahl KB,Andersen P
17-0042 was used in Flow cytometry/Cell sorting to elucidate how H56/CAF01 induces a population of circulating CD4 T cells that traffic into the Mycobacterium tuberculosis-infected lung.
Wed Mar 01 00:00:00 EST 2017
The NLRP3 inflammasome contributes to host protection during Sporothrix schenckii infection.
Immunology
Gonçalves AC,Ferreira LS,Manente FA,de Faria CMQG,Polesi MC,de Andrade CR,Zamboni DS,Carlos IZ
17-0042 was used in Flow cytometry/Cell sorting to indicate that the NLRP3 inflammasome contributes to protecion against infection from S. schenckii by linking the innate recognition of S. schenckii to the adaptive immune response.
Thu Jun 01 00:00:00 EDT 2017
Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis.
Journal of virology
Bardina SV,Brown JA,Michlmayr D,Hoffman KW,Sum J,Pletnev AG,Lira SA,Lim JK
17-0042 was used in Flow cytometry/Cell sorting to point to Ccr7 as a critical host defense restriction factor limiting neuroinflammation during acute viral infection.
Mon May 15 00:00:00 EDT 2017
IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury.
Frontiers in neurology
Gao W,Li F,Zhou Z,Xu X,Wu Y,Zhou S,Yin D,Sun D,Xiong J,Jiang R,Zhang J
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
Discrimination of the heterogeneity of bone marrow‑derived dendritic cells.
Molecular medicine reports
Wang J,Dai X,Hsu C,Ming C,He Y,Zhang J,Wei L,Zhou P,Wang CY,Yang J,Gong N
Wed Nov 01 00:00:00 EDT 2017
Immunological effects of vaccines combined with granulocyte colony-stimulating factor on a murine WEHI-3 leukemia model.
Oncology letters
Chen J,Zhang M,Zhou F,Wang J,Niu B,Zhang W
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2017
Effect of follicular helper T cells on the pathogenesis of asthma.
Experimental and therapeutic medicine
Ma X,Sun Z,Zhai P,Yu W,Wang T,Li F,Ding J
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2017
Batf3-dependent CD8α+ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.
EBioMedicine
Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2017
Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting.
Scientific reports
Atkin-Smith GK,Paone S,Zanker DJ,Duan M,Phan TK,Chen W,Hulett MD,Poon IK
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Fri Jan 06 00:00:00 EST 2017
IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.
JCI insight
Le Saout C,Luckey MA,Villarino AV,Smith M,Hasley RB,Myers TG,Imamichi H,Park JH,O'Shea JJ,Lane HC,Catalfamo M
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Thu Nov 16 00:00:00 EST 2017
Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.
Nature communications
Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Oct 17 00:00:00 EDT 2017
Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.
Nature communications
Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Oct 17 00:00:00 EDT 2017
Radiation enhanced the local and distant anti-tumor efficacy in dual immune checkpoint blockade therapy in osteosarcoma.
PloS one
Takahashi Y,Yasui T,Tamari K,Minami K,Otani K,Isohashi F,Seo Y,Kambe R,Koizumi M,Ogawa K
17-0042 was used in Flow cytometry/Cell sorting to demonstrate that radiation therapy enhances the efficacy of immune checkpoint blockade therapy, thus providing a promising therapeutic option for osteosarcoma.
Mon Jan 08 00:00:00 EST 2018
NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis.
Nature
Ma C,Kesarwala AH,Eggert T,Medina-Echeverz J,Kleiner DE,Jin P,Stroncek DF,Terabe M,Kapoor V,ElGindi M,Han M,Thornton AM,Zhang H,Egger M,Luo J,Felsher DW,McVicar DW,Weber A,Heikenwalder M,Greten TF
17-0042 was used in Flow cytometry/Cell sorting to demonstrate that dysregulation of lipid metabolism in NAFLD causes selective loss of CD4(+) T lymphocytes, promoting hepatocarcinogenesis.
Thu Mar 10 00:00:00 EST 2016
CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis.
Nature immunology
Cibrian D,Saiz ML,de la Fuente H,Sánchez-Díaz R,Moreno-Gonzalo O,Jorge I,Ferrarini A,Vázquez J,Punzón C,Fresno M,Vicente-Manzanares M,Daudén E,Fernández-Salguero PM,Martín P,Sánchez-Madrid F
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
Oligodendrocyte death results in immune-mediated CNS demyelination.
Nature neuroscience
Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides.
Clinical cancer research : an official journal of the American Association for Cancer Research
Vieyra-Garcia PA,Wei T,Naym DG,Fredholm S,Fink-Puches R,Cerroni L,Odum N,O'Malley JT,Gniadecki R,Wolf P
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Fri Jul 01 00:00:00 EDT 2016
Lineage tracing of cells involved in atherosclerosis.
Atherosclerosis
Albarrán-Juárez J,Kaur H,Grimm M,Offermanns S,Wettschureck N
17-0042 was used in Flow cytometry/Cell sorting to identify the origin of vascular smooth muscle cells and macrophages within atherosclerosis lesions.
Mon Aug 01 00:00:00 EDT 2016
Mechanisms of Acute Toxicity in NKG2D Chimeric Antigen Receptor T Cell-Treated Mice.
Journal of immunology (Baltimore, Md. : 1950)
Sentman ML,Murad JM,Cook WJ,Wu MR,Reder J,Baumeister SH,Dranoff G,Fanger MW,Sentman CL
17-0042 was used in Flow cytometry/Cell sorting to examine the mechanisms of acute toxicity in NKG2D chimeric antigen receptor T cell-treated mice.
Thu Dec 15 00:00:00 EST 2016
Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model.
Molecular medicine reports
Yue Y,Li P,Song N,Li B,Li Z,Guo Y,Zhang W,Wei MQ,Gai Z,Meng H,Wang J,Qin L
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Sun May 01 00:00:00 EDT 2016
Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.
Nature communications
Baptista MA,Keszei M,Oliveira M,Sunahara KK,Andersson J,Dahlberg CI,Worth AJ,Liedén A,Kuo IC,Wallin RP,Snapper SB,Eidsmo L,Scheynius A,Karlsson MC,Bouma G,Burns SO,Forsell MN,Thrasher AJ,Nylén S,Westerberg LS
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon Jul 18 00:00:00 EDT 2016
The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis.
Nature communications
Xu J,Zhou L,Ji L,Chen F,Fortmann K,Zhang K,Liu Q,Li K,Wang W,Wang H,Xie W,Wang Q,Liu J,Zheng B,Zhang P,Huang S,Shi T,Zhang B,Dang Y,Chen J,O'Malley BW,Moses RE,Wang P,Li L,Xiao J,Hoffmann A,Li X
17-0042 was used in Flow cytometry/Cell sorting to explore a role of REGγ in the regulation of NFκB and the effect of this on the development of bowel inflammation and associated tumour formation.
Mon Feb 22 00:00:00 EST 2016
Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.
eLife
Allison KA,Sajti E,Collier JG,Gosselin D,Troutman TD,Stone EL,Hedrick SM,Glass CK
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon Jul 04 00:00:00 EDT 2016
Normal Development and Function of T Cells in Proline Rich 7 (Prr7) Deficient Mice.
PloS one
Hrdinka M,Sudan K,Just S,Drobek A,Stepanek O,Schlüter D,Reinhold D,Jordan BA,Gintschel P,Schraven B,Kreutz MR
17-0042 was used in Flow cytometry/Cell sorting to show that Prr7 loss does not result in a major immune system defect in mice.
Wed Nov 20 00:00:00 EST 2019
Absence of apolipoprotein E protects mice from cerebral malaria.
Scientific reports
Kassa FA,Van Den Ham K,Rainone A,Fournier S,Boilard E,Olivier M
17-0042 was used in Flow cytometry/Cell sorting to reveal a unique biomarker, apolipoprotein E, for cerebral malaria.
Tue Sep 20 00:00:00 EDT 2016
Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator.
Nature communications
Zhu ML,Bakhru P,Conley B,Nelson JS,Free M,Martin A,Starmer J,Wilson EM,Su MA
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Apr 13 00:00:00 EDT 2016
Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma.
Oncoimmunology
Vandenberk L,Garg AD,Verschuere T,Koks C,Belmans J,Beullens M,Agostinis P,De Vleeschouwer S,Van Gool SW
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2016
Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination.
Scientific reports
Stifter K,Schuster C,Schlosser M,Boehm BO,Schirmbeck R
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon Jul 11 00:00:00 EDT 2016
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.
Science (New York, N.Y.)
Yoon KW,Byun S,Kwon E,Hwang SY,Chu K,Hiraki M,Jo SH,Weins A,Hakroush S,Cebulla A,Sykes DB,Greka A,Mundel P,Fisher DE,Mandinova A,Lee SW
17-0042 was used in Flow cytometry/Cell sorting to reveal that p53-induced expression of death domain 1α regulates the efficient clearance of dead cells and proper immune tolerance.
Fri Jul 31 00:00:00 EDT 2015
Distinct germinal center selection at local sites shapes memory B cell response to viral escape.
The Journal of experimental medicine
Adachi Y,Onodera T,Yamada Y,Daio R,Tsuiji M,Inoue T,Kobayashi K,Kurosaki T,Ato M,Takahashi Y
17-0042 was used in Immunohistochemistry on frozen tissues to investigate the cellular events dictating the cross-reactive memory B cell responses, showing that distinct germinal center selection at local sites shapes response to viral escape.
Mon Sep 21 00:00:00 EDT 2015
CCR4 promotes medullary entry and thymocyte-dendritic cell interactions required for central tolerance.
The Journal of experimental medicine
Hu Z,Lancaster JN,Sasiponganan C,Ehrlich LI
17-0042 was used in Immunofluorescence to demonstrate that CCR4 promotes medullary entry of the earliest post-positive selection thymocytes, as well as efficient interactions between medullary thymocytes and dendritic cells.
Mon Oct 19 00:00:00 EDT 2015
Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.
Cardiovascular research
Wan W,Liu Q,Lionakis MS,Marino AP,Anderson SA,Swamydas M,Murphy PM
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2015
B-cell very late antigen-4 deficiency reduces leukocyte recruitment and susceptibility to central nervous system autoimmunity.
Annals of neurology
Lehmann-Horn K,Sagan SA,Bernard CC,Sobel RA,Zamvil SS
17-0042 was used in Flow cytometry/Cell sorting to report that the selective inhibition of VLA-4 expression on B cells impedes CNS accumulation of B cells, and recruitment of Th17 cells and macrophages.
Fri May 01 00:00:00 EDT 2015
Negative CD4 + TIM-3 signaling confers resistance against cold preservation damage in mouse liver transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Liu Y,Ji H,Zhang Y,Shen XD,Gao F,Nguyen TT,Shang X,Lee N,Busuttil RW,Kupiec-Weglinski JW
17-0042 was used in Flow cytometry/Cell sorting to explore TIM-3-Gal-9 function in a clinically relevant murine model of hepatic cold storage and orthotopic liver transplantation.
Wed Apr 01 00:00:00 EDT 2015
Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.
Frontiers in immunology
Vogel AJ,Brown DM
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Fri Jul 10 00:00:00 EDT 2015
Premature thymic involution is independent of structural plasticity of the thymic stroma.
European journal of immunology
Franckaert D,Schlenner SM,Heirman N,Gill J,Skogberg G,Ekwall O,Put K,Linterman MA,Dooley J,Liston A
17-0042 was used in Flow cytometry/Cell sorting to investigate thymic involution in FVB/N mice, showing that disruption of the epithelial-endothelial relationship and a progressive loss of pro-T cells precedes involution, and loss of pro-T cells is sufficient to drive premature involution, suggesting that pro-T cells are the main driver of involution.
Fri May 01 00:00:00 EDT 2015
IκBNS regulates murine Th17 differentiation during gut inflammation and infection.
Journal of immunology (Baltimore, Md. : 1950)
Annemann M,Wang Z,Plaza-Sirvent C,Glauben R,Schuster M,Ewald Sander F,Mamareli P,Kühl AA,Siegmund B,Lochner M,Schmitz I
17-0042 was used in Flow cytometry/Cell sorting to study the role of nuclear IκBNS in murine Th17 cell generation upon inflammation and infection.
Sun Mar 15 00:00:00 EDT 2015
Toll-Like Receptor 4 Is an Essential Upstream Regulator of On-Time Parturition and Perinatal Viability in Mice.
Endocrinology
Wahid HH,Dorian CL,Chin PY,Hutchinson MR,Rice KC,Olson DM,Moldenhauer LM,Robertson SA
17-0042 was used in Flow cytometry/Cell sorting to describe TLR4-mediated regulation of the inflammatory response acting to drive uterine activation and control the timing of labour.
Thu Oct 01 00:00:00 EDT 2015
A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells.
Cancer biology & therapy
Kawahara M,Takaku H
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon Sep 12 00:00:00 EDT 2016
Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.
Human vaccines & immunotherapeutics
Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Fri Mar 11 00:00:00 EST 2016
Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.
Gene therapy
Rodriguez-Peña AB,Gomez-Rodriguez J,Kortum RL,Palmer DC,Yu Z,Guittard GC,Wohlfert EA,Silver PB,Misplon JA,Sommers CL,Feigenbaum L,Epstein SL,Caspi RR,Belkaid Y,Restifo NP,Samelson LE,Balagopalan L
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2015
Neonatal microbial colonization in mice promotes prolonged dominance of CD11b(+)Gr-1(+) cells and accelerated establishment of the CD4(+) T cell population in the spleen.
Immunity, inflammation and disease
Kristensen MB,Metzdorff SB,Bergström A,Damlund DS,Fink LN,Licht TR,Frøkiær H
17-0042 was used in Flow cytometry/Cell sorting to assess the microbial influence on postnatal haematopoiesis.
Tue Sep 01 00:00:00 EDT 2015
Recombinant adeno-vaccine expressing enterovirus 71-like particles against hand, foot, and mouth disease.
PLoS neglected tropical diseases
Tsou YL,Lin YW,Shao HY,Yu SL,Wu SR,Lin HY,Liu CC,Huang C,Chong P,Chow YH
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2015
Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer.
Oncotarget
Edgington-Mitchell LE,Rautela J,Duivenvoorden HM,Jayatilleke KM,van der Linden WA,Verdoes M,Bogyo M,Parker BS
17-0042 was used in Flow cytometry/Cell sorting to suggest that cysteine protease inhibition is associated with enhanced osteoclastogenesis of myeloid-derived suppressor cells in breast cancer.
Tue Sep 29 00:00:00 EDT 2015
dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.
Nature communications
Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Sep 15 00:00:00 EDT 2015
Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation.
eLife
He L,Zhang Y,Ma G,Tan P,Li Z,Zang S,Wu X,Jing J,Fang S,Zhou L,Wang Y,Huang Y,Hogan PG,Han G,Zhou Y
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Dec 08 00:00:00 EST 2015
Iron prevents the development of experimental cerebral malaria by attenuating CXCR3-mediated T cell chemotaxis.
PloS one
Van Den Ham KM,Shio MT,Rainone A,Fournier S,Krawczyk CM,Olivier M
17-0042 was used in Flow cytometry/Cell sorting to study the effect of iron in attenuating CXCR3-mediated T cell chemotaxis and migration to the brain and therefore inhibiting Experimental Cerebral Malaria pathology.
Thu Jan 21 00:00:00 EST 2016
STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE.
Journal of neuroinflammation
McWilliams IL,Rajbhandari R,Nozell S,Benveniste E,Harrington LE
17-0042 was used in Flow cytometry/Cell sorting to establish the role of STAT4 in the regulation of cytokine production during experimental autoimmune encephalomyelitis pathogenesis.
Tue Jun 30 00:00:00 EDT 2015
A Multiple Antigenic Peptide Mimicking Peptidoglycan Induced T Cell Responses to Protect Mice from Systemic Infection with Staphylococcus aureus.
PloS one
Wang XY,Huang ZX,Chen YG,Lu X,Zhu P,Wen K,Fu N,Liu BY
17-0042 was used in Flow cytometry/Cell sorting to synthesise a multiple antigenic peptide, MAP27, with the potential to augment the efficacy of vaccines against S. aureus.
Tue May 24 00:00:00 EDT 2016
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
Nature immunology
Agudo J,Ruzo A,Tung N,Salmon H,Leboeuf M,Hashimoto D,Becker C,Garrett-Sinha LA,Baccarini A,Merad M,Brown BD
17-0042 was used in Flow cytometry/Cell sorting to identify the miR-126-VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs.
Wed Jan 01 00:00:00 EST 2014
The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.
Nature immunology
Salmond RJ,Brownlie RJ,Morrison VL,Zamoyska R
17-0042 was used in Flow cytometry/Cell sorting to study how loss-of-function PTPN22 alleles can lead to the population expansion of effector and/or memory T cells and a predisposition to human autoimmunity.
Mon Sep 01 00:00:00 EDT 2014
BMP4 inhibits breast cancer metastasis by blocking myeloid-derived suppressor cell activity.
Cancer research
Cao Y,Slaney CY,Bidwell BN,Parker BS,Johnstone CN,Rautela J,Eckhardt BL,Anderson RL
17-0042 was used in Flow cytometry/Cell sorting to assess the potential for therapies based on the activation of BMP4 signalling for the treatment of breast cancer.
Mon Sep 15 00:00:00 EDT 2014
Type 1 diabetes in NOD mice unaffected by mast cell deficiency.
Diabetes
Gutierrez DA,Fu W,Schonefeldt S,Feyerabend TB,Ortiz-Lopez A,Lampi Y,Liston A,Mathis D,Rodewald HR
17-0042 was used in Flow cytometry/Cell sorting to investigate the role of mast cells in the onset and incidence of type 1 diabetes, showing that mast cell deficiency does not affect diabetes.
Sat Nov 01 00:00:00 EDT 2014
TLR2 engagement on CD4(+) T cells enhances effector functions and protective responses to Mycobacterium tuberculosis.
European journal of immunology
Reba SM,Li Q,Onwuzulike S,Ding X,Karim AF,Hernandez Y,Fulton SA,Harding CV,Lancioni CL,Nagy N,Rodriguez ME,Wearsch PA,Rojas RE
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Thu May 01 00:00:00 EDT 2014
Bronchial epithelial injury in the context of alloimmunity promotes lymphocytic bronchiolitis through hyaluronan expression.
American journal of physiology. Lung cellular and molecular physiology
Stober VP,Szczesniak C,Childress Q,Heise RL,Bortner C,Hollingsworth JW,Neuringer IP,Palmer SM,Garantziotis S
17-0042 was used in Flow cytometry/Cell sorting to study the effect of sterile bronchial epithelial injuries on alloimmunity.
Sun Jun 01 00:00:00 EDT 2014
Impact of prostate inflammation on lesion development in the POET3(+)Pten(+/-) mouse model of prostate carcinogenesis.
The American journal of pathology
Burcham GN,Cresswell GM,Snyder PW,Chen L,Liu X,Crist SA,Henry MD,Ratliff TL
17-0042 was used in Flow cytometry/Cell sorting to study the link between prostatitis and prostate cancer development using an inducible mouse model of prostatitis.
Mon Dec 01 00:00:00 EST 2014
An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
White AJ,Jenkinson WE,Cowan JE,Parnell SM,Bacon A,Jones ND,Jenkinson EJ,Anderson G
17-0042 was used in Flow cytometry/Cell sorting to investigate whether thymus microenvironments are required in iNKT cell development, showing that medullary thymic epithelial cells are essential for intrathymic development of iNKT cells.
Sat Mar 15 00:00:00 EDT 2014
T cell-derived IL-4/IL-13 protects mice against fatal Schistosoma mansoni infection independently of basophils.
Journal of immunology (Baltimore, Md. : 1950)
Schwartz C,Oeser K,Prazeres da Costa C,Layland LE,Voehringer D
17-0042 was used in Flow cytometry/Cell sorting to determine the contribution of cytokines and basophils for protective immunity against S. mansoni egg-induced pathology.
Wed Oct 01 00:00:00 EDT 2014
GM-CSF-licensed CD11b+ lung dendritic cells orchestrate Th2 immunity to Blomia tropicalis.
Journal of immunology (Baltimore, Md. : 1950)
Zhou Q,Ho AW,Schlitzer A,Tang Y,Wong KH,Wong FH,Chua YL,Angeli V,Mortellaro A,Ginhoux F,Kemeny DM
17-0042 was used in Flow cytometry/Cell sorting to identify GM-CSF-licensed CD11b(+) lung DCs as a key component for induction of Th2 responses.
Tue Jul 15 00:00:00 EDT 2014
Enhanced auto-antibody production and Mott cell formation in FcμR-deficient autoimmune mice.
International immunology
Honjo K,Kubagawa Y,Suzuki Y,Takagi M,Ohno H,Bucy RP,Izui S,Kubagawa H
17-0042 was used in Flow cytometry/Cell sorting to determine the impact of Fcmr ablation on autoimmunity.
Mon Dec 01 00:00:00 EST 2014
In TCR-stimulated T-cells, N-ras regulates specific genes and signal transduction pathways.
PloS one
Lynch SJ,Zavadil J,Pellicer A
17-0042 was used in Flow cytometry/Cell sorting to investigate how N-ras and H-ras play distinct roles in immune cells at the level of the transcriptome.
Wed Jan 28 00:00:00 EST 2015
Steroids alone or as adjunctive therapy with doxycycline fail to improve oviduct damage in mice infected with Chlamydia muridarum.
Clinical and vaccine immunology : CVI
Corr TE,Sullivan J,Frazer LC,Andrews CW,O'Connell CM,Darville T
17-0042 was used in Flow cytometry/Cell sorting to test the ability of dexamethasone to inhibit inflammation and prevent oviduct scarring in mice genitally infected with Chlamydia muridarum, showing that it fails to improve oviduct damage.
Sun Jun 01 00:00:00 EDT 2014
Efficacy of an abbreviated induction regimen of amphotericin B deoxycholate for cryptococcal meningoencephalitis: 3 days of therapy is equivalent to 14 days.
mBio
Livermore J,Howard SJ,Sharp AD,Goodwin J,Gregson L,Felton T,Schwartz JA,Walker C,Moser B,Müller W,Harrison TS,Perfect JR,Hope WW
17-0042 was used in Flow cytometry/Cell sorting to investigate the efficacy of conventional and abbreviated regimens of dAmB for cryptococcal meningoencephalitis in murine and rabbit models.
Tue Jan 28 00:00:00 EST 2014
Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface.
PloS one
Habbeddine M,Verbeke P,Karaz S,Bobé P,Kanellopoulos-Langevin C
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Jun 10 00:00:00 EDT 2015
The efficacy of tumor debulking surgery is improved by adjuvant immunotherapy using imiquimod and anti-CD40.
BMC cancer
Khong A,Cleaver AL,Fahmi Alatas M,Wylie BC,Connor T,Fisher SA,Broomfield S,Lesterhuis WJ,Currie AJ,Lake RA,Robinson BW
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Wed Dec 17 00:00:00 EST 2014
Experimental mouse models of T cell-dependent inflammatory bowel disease.
Methods in molecular biology (Clifton, N.J.)
Song-Zhao GX,Maloy KJ
17-0042-82 was used in Flow cytometry/Cell sorting to describe two T cell-dependent models of experimental murine IBD to provide reliable and tractable systems for the analyses of the induction and regulation of chronic inflammation in the gut.
Thu Apr 16 00:00:00 EDT 2015
P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica.
PloS one
Monção-Ribeiro LC,Faffe DS,Santana PT,Vieira FS,da Graça CL,Marques-da-Silva C,Machado MN,Caruso-Neves C,Zin WA,Borojevic R,Takiya CM,Coutinho-Silva R
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Thu Sep 17 00:00:00 EDT 2015
mRNA-based vaccines synergize with radiation therapy to eradicate established tumors.
Radiation oncology (London, England)
Fotin-Mleczek M,Zanzinger K,Heidenreich R,Lorenz C,Kowalczyk A,Kallen KJ,Huber SM
17-0042 was used in Flow cytometry/Cell sorting to investigate how mRNA-based vaccines interact with radiation therapy in treating established tumours.
Fri Aug 15 00:00:00 EDT 2014
MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.
The Journal of experimental medicine
Molnarfi N,Schulze-Topphoff U,Weber MS,Patarroyo JC,Prod'homme T,Varrin-Doyer M,Shetty A,Linington C,Slavin AJ,Hidalgo J,Jenne DE,Wekerle H,Sobel RA,Bernard CC,Shlomchik MJ,Zamvil SS
17-0042 was used in Flow cytometry/Cell sorting to investigate the contribution of B cells to antigen presentation and pathogenic T cell activation in the multiple sclerosis model experimental autoimmune encephalomyelitis.
Mon Dec 16 00:00:00 EST 2013
The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis.
The EMBO journal
Petersen B,Wolf M,Austermann J,van Lent P,Foell D,Ahlmann M,Kupas V,Loser K,Sorg C,Roth J,Vogl T
17-0042 was used in Flow cytometry/Cell sorting to study the role of TLR-4 ligand Mrp8/14 in inflammation and adaptive immunity.
Wed Jan 09 00:00:00 EST 2013
A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes.
The EMBO journal
Reichardt P,Patzak I,Jones K,Etemire E,Gunzer M,Hogg N
17-0042 was used in Flow cytometry/Cell sorting to study the role of the leukocyte function-associated antigen-1 (LFA-1) during T cell migration within and away from the lymph nodes.
Wed Mar 20 00:00:00 EDT 2013
Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
Cardiovascular research
Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Topical application of soluble CD83 induces IDO-mediated immune modulation, increases Foxp3+ T cells, and prolongs allogeneic corneal graft survival.
Journal of immunology (Baltimore, Md. : 1950)
Bock F,Rössner S,Onderka J,Lechmann M,Pallotta MT,Fallarino F,Boon L,Nicolette C,DeBenedette MA,Tcherepanova IY,Grohmann U,Steinkasserer A,Cursiefen C,Zinser E
17-0042 was used in Flow cytometry/Cell sorting to investigate the local immunomodulatory properties of soluble CD83 application.
Thu Aug 15 00:00:00 EDT 2013
Reduced effectiveness of CD4+Foxp3+ regulatory T cells in CD28-deficient NOD.H-2h4 mice leads to increased severity of spontaneous autoimmune thyroiditis.
Journal of immunology (Baltimore, Md. : 1950)
Ellis JS,Hong SH,Zaghouani H,Braley-Mullen H
17-0042 was used in Flow cytometry/Cell sorting to examine the role of Tregs in the development of iodine-accelerated spontaneous autoimmune thyroiditis in mice.
Fri Nov 15 00:00:00 EST 2013
Protective immunity against Toxoplasma gondii induced by DNA immunization with the gene encoding a novel vaccine candidate: calcium-dependent protein kinase 3.
BMC infectious diseases
Zhang NZ,Huang SY,Zhou DH,Chen J,Xu Y,Tian WP,Lu J,Zhu XQ
17-0042 was used in Flow cytometry/Cell sorting to investigate the potentiality of protective immunity from DNA immunization, using the gene encoding calcium-dependent protein kinase 3.
Thu Oct 31 00:00:00 EDT 2013
Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.
PloS one
Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Thu Jul 31 00:00:00 EDT 2014
Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells.
PloS one
Xiong H,Maraver A,Latkowski JA,Henderson T,Schlessinger K,Ding Y,Shen J,Tadokoro CE,Lafaille JJ
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Mon Feb 23 00:00:00 EST 2015
Toll-like receptor agonists and alpha-galactosylceramide synergistically enhance the production of interferon-gamma in murine splenocytes.
Scientific reports
Ando T,Ito H,Ohtaki H,Seishima M
17-0042 was used in Flow cytometry/Cell sorting to explore the effects of the costimulation of GalCer and TLR agonists on the immune system and cytokine production.
Fri Feb 14 00:00:00 EST 2014
Efficient capture of infected neutrophils by dendritic cells in the skin inhibits the early anti-leishmania response.
PLoS pathogens
Ribeiro-Gomes FL,Peters NC,Debrabant A,Sacks DL
17-0042 was used in Flow cytometry/Cell sorting to study how exploitation of immunosuppressive effects by L.major following rapid uptake by skin neutrophils allows inhibition of acquired resistance.
Wed Feb 01 00:00:00 EST 2012
Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-β-induced differentiation of CD4+CD25+FoxP3+ Tregs from CD4+CD25-FoxP3- T cells.
Journal of leukocyte biology
Centuori SM,Trad M,LaCasse CJ,Alizadeh D,Larmonier CB,Hanke NT,Kartchner J,Janikashvili N,Bonnotte B,Larmonier N,Katsanis E
17-0042 was used in Flow cytometry/Cell sorting to indicate that gr-MDSCs from TB hosts have the unanticipated ability to restrict immunosuppressive Tregs.
Thu Nov 01 00:00:00 EDT 2012
Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model.
Vaccine
Goicochea MA,Zapata JC,Bryant J,Davis H,Salvato MS,Lukashevich IS
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Feb 14 00:00:00 EST 2012
SA-4-1BBL costimulation inhibits conversion of conventional CD4+ T cells into CD4+ FoxP3+ T regulatory cells by production of IFN-γ.
PloS one
Madireddi S,Schabowsky RH,Srivastava AK,Sharma RK,Yolcu ES,Shirwan H
17-0042 was used in Flow cytometry/Cell sorting to investigate whether 4-1BBL can prevent the conversion of effector CD4+ cells into induced T regulatory cells in tumour settings.
Tue Feb 19 00:00:00 EST 2013
The stalk domain and the glycosylation status of the activating natural killer cell receptor NKp30 are important for ligand binding.
The Journal of biological chemistry
Hartmann J,Tran TV,Kaudeer J,Oberle K,Herrmann J,Quagliano I,Abel T,Cohnen A,Gatterdam V,Jacobs A,Wollscheid B,Tampé R,Watzl C,Diefenbach A,Koch J
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Fri Sep 07 00:00:00 EDT 2012
Novel murine dendritic cell lines: a powerful auxiliary tool for dendritic cell research.
Frontiers in immunology
Fuertes Marraco SA,Grosjean F,Duval A,Rosa M,Lavanchy C,Ashok D,Haller S,Otten LA,Steiner QG,Descombes P,Luber CA,Meissner F,Mann M,Szeles L,Reith W,Acha-Orbea H
17-0042 was used in Flow cytometry/Cell sorting to report the generation of new murine DC lines, named MutuDC, originating from cultures of splenic CD8α conventional DC (cDC) tumours.
Tue Nov 20 00:00:00 EST 2012
SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice.
PloS one
Berge T,Grønningsæter IH,Lorvik KB,Abrahamsen G,Granum S,Sundvold-Gjerstad V,Corthay A,Bogen B,Spurkland A
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Tue Aug 26 00:00:00 EDT 2014
Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.
Immunity
Wuerzberger-Davis SM,Chen Y,Yang DT,Kearns JD,Bates PW,Lynch C,Ladell NC,Yu M,Podd A,Zeng H,Huang TT,Wen R,Hoffmann A,Wang D,Miyamoto S
Published figure using CD4 monoclonal antibody (Product # 17-0042-82) in Flow Cytometry
Fri Feb 25 00:00:00 EST 2011
Immunosuppressive effects of streptozotocin-induced diabetes result in absolute lymphopenia and a relative increase of T regulatory cells.
Diabetes
Muller YD,Golshayan D,Ehirchiou D,Wyss JC,Giovannoni L,Meier R,Serre-Beinier V,Puga Yung G,Morel P,Bühler LH,Seebach JD
17-0042 was used in Flow cytometry/Cell sorting to evaluate how STZ-induced diabetes affects adaptive immunity and the consequences thereof on allograft rejection.
Thu Sep 01 00:00:00 EDT 2011
The purinergic G protein-coupled receptor 6 inhibits effector T cell activation in allergic pulmonary inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Giannattasio G,Ohta S,Boyce JR,Xing W,Balestrieri B,Boyce JA
17-0042 was used in Flow cytometry/Cell sorting to reveal the role of P2Y(6) receptors for protecting the lung against exuberant allergen-induced pulmonary inflammation.
Mon Aug 01 00:00:00 EDT 2011
Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization.
Journal of immunology (Baltimore, Md. : 1950)
Schmidt NW,Harty JT
17-0042 was used in Flow cytometry/Cell sorting to investigate whether unrelated infections will compromise numbers of Plasmodium-specific memory CD8 T cells, showing that attrition of Plasmodium-specific cells is rescued by booster immunisation.
Fri Apr 01 00:00:00 EDT 2011
Combination treatment of mice with CRx-153 (nortriptyline and desloratadine) decreases the severity of experimental autoimmune encephalomyelitis.
Cellular immunology
Podojil JR,Padval MV,Miller SD
17-0042 was used in Flow cytometry/Cell sorting to determine if treatment of PLP(139-151)-induced R-EAE with a combination of two drugs decreases R-EAE disease.
Fri Oct 14 00:00:00 EDT 2011
Low CD4/CD8 T-cell ratio associated with inflammatory arthropathy in human T-cell leukemia virus type I Tax transgenic mice.
PloS one
Ohsugi T,Kumasaka T
17-0042 was used in Flow cytometry/Cell sorting to identify the primary T-cell subsets involved in the development of arthropathy in Tax transgenic mice.
Fri Apr 01 00:00:00 EDT 2011
One naive T cell, multiple fates in CD8+ T cell differentiation.
The Journal of experimental medicine
Gerlach C,van Heijst JW,Swart E,Sie D,Armstrong N,Kerkhoven RM,Zehn D,Bevan MJ,Schepers K,Schumacher TN
17-0042 was used in Flow cytometry/Cell sorting to assess the potential for development of single naive T cells into different subsets.
Mon Jun 07 00:00:00 EDT 2010
A CD1d-dependent antagonist inhibits the activation of invariant NKT cells and prevents development of allergen-induced airway hyperreactivity.
Journal of immunology (Baltimore, Md. : 1950)
Lombardi V,Stock P,Singh AK,Kerzerho J,Yang W,Sullivan BA,Li X,Shiratsuchi T,Hnatiuk NE,Howell AR,Yu KO,Porcelli SA,Tsuji M,Kronenberg M,Wilson SB,Akbari O
17-0042 was used in Flow cytometry/Cell sorting to test whether iNKT cell-targeted therapy could be used to treat allergen-induced airway disease.
Mon Feb 15 00:00:00 EST 2010
Cutting edge: spontaneous development of IL-17-producing gamma delta T cells in the thymus occurs via a TGF-beta 1-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Do JS,Fink PJ,Li L,Spolski R,Robinson J,Leonard WJ,Letterio JJ,Min B
17-0042 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the generation of gammadelta T cells, showing that it occurs via a TGF-beta 1-dependent mechanism.
Mon Feb 15 00:00:00 EST 2010
T follicular helper cells differentiate from Th2 cells in response to helminth antigens.
The Journal of experimental medicine
Glatman Zaretsky A,Taylor JJ,King IL,Marshall FA,Mohrs M,Pearce EJ
17-0042 was used in Immunohistochemistry on frozen tissues to investigate the relationship between T follicular helper cells and T helper subsets.
Mon May 11 00:00:00 EDT 2009
T follicular helper cells differentiate from Th2 cells in response to helminth antigens.
The Journal of experimental medicine
Glatman Zaretsky A,Taylor JJ,King IL,Marshall FA,Mohrs M,Pearce EJ
17-0042 was used in Immunohistochemistry on frozen tissues to investigate the relationship between T follicular helper cells and T helper subsets.
Mon May 11 00:00:00 EDT 2009
IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells.
The Journal of experimental medicine
King IL,Mohrs M
17-0042 was used in Immunohistochemistry on frozen tissues to investigate the location of IL-4-producing T cells in the lymph nodes.
Mon May 11 00:00:00 EDT 2009
Dendritic cells matured by inflammation induce CD86-dependent priming of naive CD8+ T cells in the absence of their cognate peptide antigen.
Journal of immunology (Baltimore, Md. : 1950)
Maroof A,Beattie L,Kirby A,Coles M,Kaye PM
17-0042 was used in Flow cytometry/Cell sorting to study how inflammation-matured DCs can induce Ag-independent T cell proliferation.
Tue Dec 01 00:00:00 EST 2009
NKG2A inhibits invariant NKT cell activation in hepatic injury.
Journal of immunology (Baltimore, Md. : 1950)
Kawamura T,Takeda K,Kaneda H,Matsumoto H,Hayakawa Y,Raulet DH,Ikarashi Y,Kronenberg M,Yagita H,Kinoshita K,Abo T,Okumura K,Smyth MJ
17-0042 was used in Flow cytometry/Cell sorting to investigate the role of NK cell receptors in iNKT cell activation, showing that NKG2A-mediated signalling negatively regulated iNKT activation and hepatic injury.
Thu Jan 01 00:00:00 EST 2009
Induction of airway hyperreactivity by IL-25 is dependent on a subset of invariant NKT cells expressing IL-17RB.
Journal of immunology (Baltimore, Md. : 1950)
Stock P,Lombardi V,Kohlrautz V,Akbari O
17-0042 was used in Flow cytometry/Cell sorting to investigate the invariant NKT cell dependent pathway by which IL-25 induces Th2 responses and airway hyperreactivity in mice.
Wed Apr 15 00:00:00 EDT 2009
GITR Blockade Facilitates Treg Mediated Allograft Survival.
Transplantation
Sonawane SB,Kim JI,Lee MK,Lee SH,Duff PE,Moore DJ,Lian MM,Deng S,Choi Y,Yeh H,Caton AJ,Markmann JF
17-0042 was used in Flow cytometry/Cell sorting to study how inflammation and other innate immune signals may activate antigen presenting cells to up-regulate GITR.
Fri Nov 27 00:00:00 EST 2009
Induction of protective immunity by vaccination against Chlamydia trachomatis using the major outer membrane protein adjuvanted with CpG oligodeoxynucleotide coupled to the nontoxic B subunit of cholera toxin.
Vaccine
Cheng C,Bettahi I,Cruz-Fisher MI,Pal S,Jain P,Jia Z,Holmgren J,Harandi AM,de la Maza LM
17-0042 was used in Flow cytometry/Cell sorting to test the efficacy of immunisation with the nMOMP of Chlamydia trachomatis mouse pneumonitis serovar in combination with CpG oligodeoxynucleotide linked to the nontoxic B subunit of cholera toxin to elicit a protective immune response to C. trachomatis.
Mon Oct 19 00:00:00 EDT 2009
Lack of IL-6 during coxsackievirus infection heightens the early immune response resulting in increased severity of chronic autoimmune myocarditis.
PloS one
Poffenberger MC,Straka N,El Warry N,Fang D,Shanina I,Horwitz MS
17-0042 was used in Flow cytometry/Cell sorting to investigate the mechanism by which coxsackievirus infection leads to chronic autoimmune pathology, showing that lack of IL-6 heightens the early immune response.
Thu Jul 09 00:00:00 EDT 2009
Some putative prebiotics increase the severity of Salmonella enterica serovar Typhimurium infection in mice.
BMC microbiology
Petersen A,Heegaard PM,Pedersen AL,Andersen JB,Sørensen RB,Frøkiaer H,Lahtinen SJ,Ouwehand AC,Poulsen M,Licht TR
17-0042 was used in Flow cytometry/Cell sorting to examine whether Salmonella infection could be prevented by administration of dietary carbohydrates with different structures and digestibility profiles.
Mon Nov 30 00:00:00 EST 2009
Autoantibody production in lpr/lpr gld/gld mice reflects accumulation of CD4+ effector cells that are resistant to regulatory T cell activity.
Journal of autoimmunity
Hondowicz BD,Fields ML,Nish SA,Larkin J,Caton AJ,Erikson J
17-0042 was used in Flow cytometry/Cell sorting to show that Treg cells block lpr/lpr gld/gld Th cells from providing help to anti-chromatin B cells in an in vivo transfer system.
Mon Sep 01 00:00:00 EDT 2008
Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome.
The American journal of pathology
Gongora MC,Lob HE,Landmesser U,Guzik TJ,Martin WD,Ozumi K,Wall SM,Wilson DS,Murthy N,Gravanis M,Fukai T,Harrison DG
17-0042 was used in Flow cytometry/Cell sorting to study the role of acute SOD3 reduction in lung injury.
Wed Oct 01 00:00:00 EDT 2008
Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Fas(lpr) mice.
Journal of immunology (Baltimore, Md. : 1950)
Menke J,Hsu MY,Byrne KT,Lucas JA,Rabacal WA,Croker BP,Zong XH,Stanley ER,Kelley VR
17-0042 was used in Flow cytometry/Cell sorting to investigate the role of UVB in cutaneous lupus erythematosus, showing that UVB triggers it through a CSF-1-dependent, macrophage-mediated mechanism.
Sat Nov 15 00:00:00 EST 2008
Chimeric NKG2D modified T cells inhibit systemic T-cell lymphoma growth in a manner involving multiple cytokines and cytotoxic pathways.
Cancer research
Zhang T,Barber A,Sentman CL
17-0042 was used in Flow cytometry/Cell sorting to investigate the efficiency and mechanisms by which chimeric NKG2D-modified T cells inhibit systemic T-cell lymphoma growth.
Thu Nov 15 00:00:00 EST 2007
IL-10 regulates movement of intestinally derived CD4+ T cells to the liver.
Journal of immunology (Baltimore, Md. : 1950)
Bliss SK,Bliss SP,Beiting DP,Alcaraz A,Appleton JA
Fri Jun 15 00:00:00 EDT 2007
IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals.
Journal of immunology (Baltimore, Md. : 1950)
Li X,McKinstry KK,Swain SL,Dalton DK
17-0042 was used in Flow cytometry/Cell sorting to investigate IFN-γ-mediated apoptosis mechanisms of CD4+ T Cells during mycobacterial infection, which operate through induction of intra- and extracellular apoptosis signals.
Sun Jul 15 00:00:00 EDT 2007
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.
Immunity
Veldhoen M,Hocking RJ,Atkins CJ,Locksley RM,Stockinger B
17-0042 was used in Flow cytometry/Cell sorting to investigate the generation of IL-17-producing T cells from naive CD4 T cells, showing that TGFbeta supports de novo differentiation of IL-17-producing T cells.
Wed Feb 01 00:00:00 EST 2006
A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma.
The Journal of clinical investigation
Köhl J,Baelder R,Lewkowich IP,Pandey MK,Hawlisch H,Wang L,Best J,Herman NS,Sproles AA,Zwirner J,Whitsett JA,Gerard C,Sfyroera G,Lambris JD,Wills-Karp M
17-0042 was used in Flow cytometry/Cell sorting to investigate the role of complement component 5 in asthma.
Wed Mar 01 00:00:00 EST 2006
Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha}.
Proceedings of the National Academy of Sciences of the United States of America
Rubinstein MP,Kovar M,Purton JF,Cho JH,Boyman O,Surh CD,Sprent J
Tue Jun 13 00:00:00 EDT 2006
In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes.
The Journal of experimental medicine
Tang Q,Henriksen KJ,Bi M,Finger EB,Szot G,Ye J,Masteller EL,McDevitt H,Bonyhadi M,Bluestone JA
17-0042 was used in Flow cytometry/Cell sorting to develop a robust method to expand antigen-specific regulatory T cells from autoimmune-prone, non-obese diabetic mice.
Mon Jun 07 00:00:00 EDT 2004
Ligand-dependent inhibition of CD1d-restricted NKT cell development in mice transgenic for the activating receptor Ly49D.
The Journal of experimental medicine
Voyle RB,Beermann F,Lees RK,Schümann J,Zimmer J,Held W,MacDonald HR
17-0042 was used in Flow cytometry/Cell sorting to investigate whether immunoreceptor-tyrosine activation and inhibition motifs associated with NK receptors augment or attenuate perceived TCR signals.
Mon Apr 07 00:00:00 EDT 2003