Invitrogen

CD4 Monoclonal Antibody (RM4-5), APC-eFluor™ 780, eBioscience™

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

97 Published Figures

196 References

View all (606) CD4 antibodies

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CD4 Antibody (47-0042-82) in Flow

Staining of BALB/c splenocytes with Anti-Mouse CD3e FITC (Product # 11-0031-82) and 0.06 µg of Rat IgG2a kappa Isotype Control APC-eFluor® 780 (Product # 47-4321-82) (left) or 0.06 µg of Anti-Mouse CD4 APC-eFluor® 780 (right). Total viable cells were used for analysis.

Product Image Gallery

CD4 Antibody — Staining of mouse splenocytes and bone marrow cells. Right: As expected based on known relative expression patterns, CD4 clone RM4-5 stains a subset of splenocytes and does not stain any bone marrow cells. Details: Balb/c bone marrow cells (left) and splenocytes (middle) were surface stained with CD4 (clone RM4-5) followed by staining with 7-AAD. Viable bone marrow cells in the lymphoid (blue histogram) and myeloid (purple histogram) gates and viable splenocytes (orange histogram) were used for analysis. {RE}

Product Details

47-0042-82

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

0.125 µg/test

View 196 publications 196 publications

Product Specifications

Species Reactivity

Mouse

Published species

Human, Mouse

Host/Isotype

Rat / IgG2a, kappa

Recommended Isotype Control

Rat IgG2a kappa Isotype Control (eBR2a), APC-eFluor™ 780, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

RM4-5

Conjugate

APC-eFluor™ 780 APC-eFluor™ 780 APC-eFluor™ 780

Excitation/Emission Max

756/785 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1272183

Product Specific Information

Description: The RM4-5 monoclonal antibody reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor expressed by a majority of thymocytes, subpopulation of mature T cells and dendritic cells. CD4 binds to MHC class II on the surface of antigen presenting cells and plays an important role both in T cell development and in optimal functioning of mature T cells. In T cells, CD4 associates with protein tyrosine kinase p56lck through its cytoplasmic tail. Binding of RM4-5 is blocked by GK1.5.

Applications Reported: This RM4-5 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This RM4-5 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

APC-eFluor 780 emits at 780 nm and is excited with the Red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome.

Light sensitivity: This tandem is sensitive to photo-induced oxidation. Please protect this vial and stained samples from light.

Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-8222) (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product # 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.

Excitation: 633-647 nm; Emission: 780 nm; Laser: Red Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Role of affinity in plasma cell development in the germinal center light zone.

The Journal of experimental medicine

ElTanbouly MA,Ramos V,MacLean AJ,Chen ST,Loewe M,Steinbach S,Ben Tanfous T,Johnson B,Cipolla M,Gazumyan A,Oliveira TY,Nussenzweig MC

47-0042-82 was used in Flow Cytometry to show that initial PC selection overlaps with GC B cell selection, but that the PC compartment accumulates a less diverse and higher affinity collection of antibodies over time.

Mon Jan 01 00:00:00 EST 2024

Impact of broad-spectrum antibiotics on the gut-microbiota-spleen-brain axis.

Brain, behavior, & immunity - health

Wan X,Eguchi A,Sakamoto A,Fujita Y,Yang Y,Qu Y,Hatano M,Mori C,Hashimoto K

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2023

Spleen-targeted neoantigen DNA vaccine for personalized immunotherapy of hepatocellular carcinoma.

EMBO molecular medicine

Wu M,Luo Z,Cai Z,Mao Q,Li Z,Li H,Zhang C,Zhang Y,Zhong A,Wu L,Liu X

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Oct 11 00:00:00 EDT 2023

CXCR1 drives the pathogenesis of EAE and ARDS via boosting dendritic cells-dependent inflammation.

Cell death & disease

Zhuang W,Zhou J,Zhong L,Lv J,Zhong X,Liu G,Xie L,Wang C,Saimaier K,Han S,Shi C,Hua Q,Zhang R,Xie X,Du C

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Sep 14 00:00:00 EDT 2023

Platelet factors attenuate inflammation and rescue cognition in ageing.

Nature

Schroer AB,Ventura PB,Sucharov J,Misra R,Chui MKK,Bieri G,Horowitz AM,Smith LK,Encabo K,Tenggara I,Couthouis J,Gross JD,Chan JM,Luke A,Villeda SA

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

Klebsiella pneumoniae Induces Inflammatory Bowel Disease Through Caspase-11-Mediated IL18 in the Gut Epithelial Cells.

Cellular and molecular gastroenterology and hepatology

Zhang Q,Su X,Zhang C,Chen W,Wang Y,Yang X,Liu D,Zhang Y,Yang R

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Feb 23 00:00:00 EST 2023

Icariin restrains NLRP3 inflammasome-mediated Th2 immune responses and ameliorates atopic dermatitis through modulating a novel lncRNA MALAT1/miR-124-3p axis.

Pharmaceutical biology

Zhao W,Yu HH,Meng WW,Liu AM,Zhang BX,Wang Y,Li J,Wang L,Fang YF

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Fri Dec 01 00:00:00 EST 2023

Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration.

Cell metabolism

Becker M,Joseph SS,Garcia-Carrizo F,Tom RZ,Opaleva D,Serr I,Tschöp MH,Schulz TJ,Hofmann SM,Daniel C

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Oct 03 00:00:00 EDT 2023

Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function.

British journal of pharmacology

Liao W,Foo HYC,Tran TNQ,Chai CLL,Wong WSF

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2023

Palmitoyl transferases act as novel drug targets for pancreatic cancer.

Journal of translational medicine

Lin Z,Lv Z,Liu X,Huang K

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Mon Apr 10 00:00:00 EDT 2023

Antibody feedback regulates immune memory after SARS-CoV-2 mRNA vaccination.

Nature

Schaefer-Babajew D,Wang Z,Muecksch F,Cho A,Loewe M,Cipolla M,Raspe R,Johnson B,Canis M,DaSilva J,Ramos V,Turroja M,Millard KG,Schmidt F,Witte L,Dizon J,Shimeliovich I,Yao KH,Oliveira TY,Gazumyan A,Gaebler C,Bieniasz PD,Hatziioannou T,Caskey M,Nussenzweig MC

47-0042-82 was used in Flow cytometry/Cell sorting to indicate that pre-existing high-affinity antibodies bias germinal centre and memory B cell selection through two distinct mechanisms: (1) by lowering the activation threshold for B cells, thereby permitting abundant lower-affinity clones to participate in the immune response; and (2) through direct masking of their cognate epitopes.

Sun Jan 01 00:00:00 EST 2023

SARS-CoV-2 spike protein promotes inflammatory cytokine activation and aggravates rheumatoid arthritis.

Cell communication and signaling : CCS

Lee AR,Woo JS,Lee SY,Lee YS,Jung J,Lee CR,Park SH,Cho ML

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Mar 02 00:00:00 EST 2023

TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.

Frontiers in immunology

O'Neill TJ,Gewies A,Seeholzer T,Krappmann D

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Mon Feb 13 00:00:00 EST 2023

Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Continuous germinal center invasion contributes to the diversity of the immune response.

Cell

Hägglöf T,Cipolla M,Loewe M,Chen ST,Mesin L,Hartweger H,ElTanbouly MA,Cho A,Gazumyan A,Ramos V,Stamatatos L,Oliveira TY,Nussenzweig MC,Viant C

47-0042-82 was used in Flow cytometry/Cell sorting to show that naive B cells continuously enter GCs where they compete for T cell help and undergo clonal expansion.

Thu Jan 05 00:00:00 EST 2023

Excessive apoptosis of Rip1-deficient T cells leads to premature aging.

EMBO reports

Wang L,Zhang X,Zhang H,Lu K,Li M,Li X,Ou Y,Zhao X,Wu X,Wu X,Liu J,Xing M,Liu H,Zhang Y,Tan Y,Li F,Deng X,Deng J,Zhang X,Li J,Zhao Y,Ding Q,Wang H,Wang X,Luo Y,Zhou B,Zhang H

47-0042-82 was used in Flow Cytometry to find that T-cell-specific Rip1 KO mice show similar age-related T cell changes and exhibit signs of accelerated aging-like phenotypes, including inflammation, multiple age-related diseases, and a shorter lifespan.

Wed Dec 06 00:00:00 EST 2023

Aryl hydrocarbon receptor activation ameliorates experimental colitis by modulating the tolerogenic dendritic and regulatory T cell formation.

Cell & bioscience

Cui X,Ye Z,Wang D,Yang Y,Jiao C,Ma J,Tang N,Zhang H

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Sat Apr 23 00:00:00 EDT 2022

IL-33 induces thymic involution-associated naive T cell aging and impairs host control of severe infection.

Nature communications

Xu L,Wei C,Chen Y,Wu Y,Shou X,Chen W,Lu D,Sun H,Li W,Yu B,Wang X,Zhang X,Yu Y,Lei Z,Tang R,Zhu J,Li Y,Lu L,Zhou H,Zhou S,Su C,Chen X

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Sat Nov 12 00:00:00 EST 2022

Fringe GlcNAc-transferases differentially extend O-fucose on endogenous NOTCH1 in mouse activated T cells.

The Journal of biological chemistry

Matsumoto K,Kumar V,Varshney S,Nairn AV,Ito A,Pennarubia F,Moremen KW,Stanley P,Haltiwanger RS

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Fri Jul 01 00:00:00 EDT 2022

Breast cancer cell-derived extracellular vesicles promote CD8⁺ T cell exhaustion via TGF-β type II receptor signaling.

Nature communications

Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2022

The parasitic worm product ES-62 protects the osteoimmunology axis in a mouse model of obesity-accelerated ageing.

Frontiers in immunology

Harnett MM,Doonan J,Lumb FE,Crowe J,Damink RO,Buitrago G,Duncombe-Moore J,Wilkinson DI,Suckling CJ,Selman C,Harnett W

47-0042-82 was used in Flow cytometry/Cell sorting to report the ability of small drug-like molecule analogues of ES-62 to mimic some of its key actions, particularly in strongly protecting trabecular bone structure, highlighting the translational potential of these studies.

Fri Sep 16 00:00:00 EDT 2022

Monogenic TCRβ Assembly and Expression Are Paramount for Uniform Antigen Receptor Specificity of Individual αβ T Lymphocytes.

Journal of immunology (Baltimore, Md. : 1950)

Culberson EJ,Bassing CH

47-0042-82 was used in Flow cytometry/Cell sorting to show that mechanisms governing monogenic assembly and expression of TCRβ genes in individual cells are paramount for uniform specificity of αβ T lymphocytes.

Fri Jul 01 00:00:00 EDT 2022

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection.

Cell reports

VanDyke D,Iglesias M,Tomala J,Young A,Smith J,Perry JA,Gebara E,Cross AR,Cheung LS,Dykema AG,Orcutt-Jahns BT,Henclová T,Golias J,Balolong J,Tomasovic LM,Funda D,Meyer AS,Pardoll DM,Hester J,Issa F,Hunter CA,Anderson MS,Bluestone JA,Raimondi G,Spangler JB

47-0042-82 was used in Flow cytometry/Cell sorting to provide a roadmap for IC design and establish a Treg-biased immunotherapy that could be clinically translated for autoimmune disease treatment.

Tue Oct 18 00:00:00 EDT 2022

Protocol to quantify and characterize contact between T cells and antigen-presenting cells in the antigen-draining lymph nodes of mice using flow cytometry.

STAR protocols

Tatsumi N,Davila-Pagan A,Kumamoto Y

47-0042-82 was used in Flow cytometry/Cell sorting to present a simple flow-cytometry-based protocol for quantitating T cell-APC contacts in the antigen-draining lymph node in mice immunized with ovalbumin (OVA).

Fri Dec 16 00:00:00 EST 2022

Development of a human skin commensal microbe for bacteriotherapy of atopic dermatitis and use in a phase 1 randomized clinical trial.

Nature medicine

Nakatsuji T,Hata TR,Tong Y,Cheng JY,Shafiq F,Butcher AM,Salem SS,Brinton SL,Rudman Spergel AK,Johnson K,Jepson B,Calatroni A,David G,Ramirez-Gama M,Taylor P,Leung DYM,Gallo RL

47-0042-82 was used in Flow Cytometry to study the safety and mechanisms of action of Staphylococcus hominis A9 (ShA9) as a topical therapy for atopic dermatitis.

Thu Apr 01 00:00:00 EDT 2021

Skin inflammation activates intestinal stromal fibroblasts and promotes colitis.

The Journal of clinical investigation

Dokoshi T,Seidman JS,Cavagnero KJ,Li F,Liggins MC,Taylor BC,Olvera J,Knight R,Chang JT,Salzman NH,Gallo RL

47-0042-82 was used in Flow Cytometry to understand whether fibroblasts participate in the pathogenesis of inflammatory bowel diseases and if hyaluronan could act as a signal from the skin to alter intestinal immune function through effects on fat cell differentiation.

Mon Nov 01 00:00:00 EDT 2021

Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.

The Journal of experimental medicine

Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Mon Apr 05 00:00:00 EDT 2021

Multiplexed CRISPR/CAS9-mediated engineering of pre-clinical mouse models bearing native human B cell receptors.

The EMBO journal

Wang X,Ray R,Kratochvil S,Melzi E,Lin YC,Giguere S,Xu L,Warner J,Cheon D,Liguori A,Groschel B,Phelps N,Adachi Y,Tingle R,Wu L,Crotty S,Kirsch KH,Nair U,Schief WR,Batista FD

47-0042 was used in Flow cytometry/Cell sorting to report a one-step CRISPR/Cas9 KI methodology to combine the insertion of human germline immunoglobulin heavy and light chains at their endogenous loci in mice.

Fri Jan 15 00:00:00 EST 2021

Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer.

Cancer immunology, immunotherapy : CII

Shi Y,Fu Y,Zhang X,Zhao G,Yao Y,Guo Y,Ma G,Bai S,Li H

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2021

Potential therapeutic effects of interleukin-35 on the differentiation of naïve T cells into Helios⁺Foxp3⁺ Tregs in clinical and experimental acute respiratory distress syndrome.

Molecular immunology

Wang C,Xie K,Li K,Lin S,Xu F

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Apr 01 00:00:00 EDT 2021

Feline adipose tissue-derived mesenchymal stem cells pretreated with IFN-γ enhance immunomodulatory effects through the PGE₂ pathway.

Journal of veterinary science

Park SG,An JH,Li Q,Chae HK,Park SM,Lee JH,Ahn JO,Song WJ,Youn HY

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Mon Mar 01 00:00:00 EST 2021

Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.

The Journal of international medical research

Li W,Luo Y,Xu H,Ma Q,Yao Q

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Apr 01 00:00:00 EDT 2021

Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation.

Theranostics

Chen L,Chen H,Ye J,Ge Y,Wang H,Dai E,Ren J,Liu W,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Aug 04 00:00:00 EDT 2021

Antitumor efficacy of a neoantigen cancer vaccine delivered by electroporation is influenced by microbiota composition.

Oncoimmunology

Lione L,Salvatori E,Petrazzuolo A,Massacci A,Maggio R,Confroti A,Compagnone M,Aurisicchio L,Ciliberto G,Palombo F

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Mar 23 00:00:00 EDT 2021

Evaluation of DNA-Launched Virus-Like Particle Vaccines in an Immune Competent Mouse Model of Chikungunya Virus Infection.

Vaccines

Rayner JO,Kim JH,Roberts RW,Wood RR,Fouty B,Solodushko V

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Fri Apr 02 00:00:00 EDT 2021

Gut Microbiota Dysbiosis Induced by Intracerebral Hemorrhage Aggravates Neuroinflammation in Mice.

Frontiers in microbiology

Yu X,Zhou G,Shao B,Zhou H,Xu C,Yan F,Wang L,Chen G,Li J,Fu X

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed May 26 00:00:00 EDT 2021

Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.

EBioMedicine

Okada R,Furusawa A,Vermeer DW,Inagaki F,Wakiyama H,Kato T,Nagaya T,Choyke PL,Spanos WC,Allen CT,Kobayashi H

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Activation of Bone Marrow Adaptive Immunity in Type 2 Diabetes: Rescue by Co-stimulation Modulator Abatacept.

Frontiers in immunology

Santopaolo M,Sullivan N,Thomas AC,Alvino VV,Nicholson LB,Gu Y,Spinetti G,Kallikourdis M,Blom A,Madeddu P

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Fri Jul 02 00:00:00 EDT 2021

Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer.

Nature communications

Huang Y,Guan Z,Dai X,Shen Y,Wei Q,Ren L,Jiang J,Xiao Z,Jiang Y,Liu D,Huang Z,Xu X,Luo Y,Zhao C

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Jul 14 00:00:00 EDT 2021

Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE^-/- mice in the presence and absence of immunomodulation with fingolimod.

Data in brief

Diaz Diaz AC,Malone K,Shearer JA,Moore AC,Waeber C

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2021

Ddb1 Is Essential for the Expansion of CD4⁺ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.

Frontiers in immunology

Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Mon Dec 20 00:00:00 EST 2021

Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes.

Cell reports

Sano T,Kageyama T,Fang V,Kedmi R,Martinez CS,Talbot J,Chen A,Cabrera I,Gorshko O,Kurakake R,Yang Y,Ng C,Schwab SR,Littman DR

47-0042-82 was used in Flow Cytometry to show that intestine-draining mesenteric lymph nodes (MLNs), not intestine proper, are the dominant site of SFB-induced intestinal Th17 cell differentiation.

Tue Aug 24 00:00:00 EDT 2021

Local Sustained GM-CSF Delivery by Genetically Engineered Encapsulated Cells Enhanced Both Cellular and Humoral SARS-CoV-2 Spike-Specific Immune Response in an Experimental Murine Spike DNA Vaccination Model.

Vaccines

Vernet R,Charrier E,Cosset E,Fièvre S,Tomasello U,Grogg J,Mach N

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Mon May 10 00:00:00 EDT 2021

Sequencing, cloning, and antigen binding analysis of monoclonal antibodies isolated from single mouse B cells.

STAR protocols

Viant C,Escolano A,Chen ST,Nussenzweig MC

47-0042-82 was used in Flow Cytometry to analyze the BCRs of different mouse B cell populations for somatic hypermutations, clonal and phylogenic relationships, and their affinity for cognate antigen.

Fri Jun 18 00:00:00 EDT 2021

Sequencing, cloning, and antigen binding analysis of monoclonal antibodies isolated from single mouse B cells.

STAR protocols

Viant C,Escolano A,Chen ST,Nussenzweig MC

Fri Jun 18 00:00:00 EDT 2021

Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis.

Journal of neuroinflammation

Chen YH,Eskandarpour M,Zhang X,Galatowicz G,Greenwood J,Lightman S,Calder V

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Feb 18 00:00:00 EST 2021

Prenatal cadmium exposure does not induce greater incidence or earlier onset of autoimmunity in the offspring.

PloS one

McCall JL,Blair HC,Blethen KE,Hall C,Elliott M,Barnett JB

47-0042-82 was used in Flow cytometry/Cell sorting to study the effects of prenatal Cd exposure on the development of autoimmune diabetes and arthritis.

Fri Nov 12 00:00:00 EST 2021

Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.

STAR protocols

Skordos I,Demeyer A,Beyaert R

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Fri Mar 19 00:00:00 EDT 2021

Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.

STAR protocols

Skordos I,Demeyer A,Beyaert R

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Fri Mar 19 00:00:00 EDT 2021

STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer.

Journal for immunotherapy of cancer

Lee SJ,Yang H,Kim WR,Lee YS,Lee WS,Kong SJ,Lee HJ,Kim JH,Cheon J,Kang B,Chon HJ,Kim C

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Jun 01 00:00:00 EDT 2021

Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.

PloS one

Cohen AA,Yang Z,Gnanapragasam PNP,Ou S,Dam KA,Wang H,Bjorkman PJ

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Fri Oct 15 00:00:00 EDT 2021

Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.

PloS one

Cohen AA,Yang Z,Gnanapragasam PNP,Ou S,Dam KA,Wang H,Bjorkman PJ

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Fri Oct 15 00:00:00 EDT 2021

Developmental Relationships of Four Exhausted CD8⁺ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms.

Immunity

Beltra JC,Manne S,Abdel-Hakeem MS,Kurachi M,Giles JR,Chen Z,Casella V,Ngiow SF,Khan O,Huang YJ,Yan P,Nzingha K,Xu W,Amaravadi RK,Xu X,Karakousis GC,Mitchell TC,Schuchter LM,Huang AC,Wherry EJ

47-0042-82 was used in Flow cytometry/Cell sorting to reveal a four-stage developmental hierarchy for Tex cells and define the molecular, transcriptional, and epigenetic mechanisms that could provide opportunities to improve cancer immunotherapy.

Tue May 19 00:00:00 EDT 2020

C/EBPα and GATA-2 Mutations Induce Bilineage Acute Erythroid Leukemia through Transformation of a Neomorphic Neutrophil-Erythroid Progenitor.

Cancer cell

Di Genua C,Valletta S,Buono M,Stoilova B,Sweeney C,Rodriguez-Meira A,Grover A,Drissen R,Meng Y,Beveridge R,Aboukhalil Z,Karamitros D,Belderbos ME,Bystrykh L,Thongjuea S,Vyas P,Nerlov C

47-0042 was used in Flow cytometry/Cell sorting to show that combined biallelic Cebpa and Gata2 zinc finger-1 (ZnF1) mutations cooperatively induce bilineage AEL, and that the major leukemia-initiating cell (LIC) population has a neutrophil-monocyte progenitor (NMP) phenotype.

Mon May 11 00:00:00 EDT 2020

Visualizing Synaptic Transfer of Tumor Antigens among Dendritic Cells.

Cancer cell

Ruhland MK,Roberts EW,Cai E,Mujal AM,Marchuk K,Beppler C,Nam D,Serwas NK,Binnewies M,Krummel MF

47-0042-82 was used in Flow Cytometry to demonstrate if tumor proteins are carried to the lymph node within discrete vesicles inside dendritic cells and are then transferred among dendritic cell subsets.

Mon Jun 08 00:00:00 EDT 2020

Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.

The Journal of clinical investigation

Webb LM,Sengupta S,Edell C,Piedra-Quintero ZL,Amici SA,Miranda JN,Bevins M,Kennemer A,Laliotis G,Tsichlis PN,Guerau-de-Arellano M

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

Methnaridine is an orally bioavailable, fast-killing and long-acting antimalarial agent that cures Plasmodium infections in mice.

British journal of pharmacology

Wang W,Yao J,Chen Z,Sun Y,Shi Y,Wei Y,Zhou H,Yu Y,Li S,Duan L

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

MALT1 targeting suppresses CARD14-induced psoriatic dermatitis in mice.

EMBO reports

Van Nuffel E,Staal J,Baudelet G,Haegman M,Driege Y,Hochepied T,Afonina IS,Beyaert R

47-0042-82 was used in Flow Cytometry to investigate if inducible keratinocyte-specific expression of CARD14E138A in mice rapidly induces epidermal thickening and inflammation as well as increased expression of several genes associated with psoriasis in humans.

Fri Jul 03 00:00:00 EDT 2020

The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet-accelerated mouse model of ageing.

PLoS pathogens

Crowe J,Lumb FE,Doonan J,Broussard M,Tarafdar A,Pineda MA,Landabaso C,Mulvey L,Hoskisson PA,Babayan SA,Selman C,Harnett W,Harnett MM

47-0042-82 was used in Flow Cytometry to investigate the potential of ES-62, an anti-inflammatory secreted product of the filarial nematode Acanthocheilonema viteae, to improve healthspan (the period of life before diseases of ageing appear) by targeting the chronic inflammation that drives metabolic dysregulation underpinning ageing-induced ill-health.

Sun Mar 01 00:00:00 EST 2020

DKK2 blockage-mediated immunotherapy enhances anti-angiogenic therapy of Kras mutated colorectal cancer.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Hu J,Wang Z,Chen Z,Li A,Sun J,Zheng M,Wu J,Shen T,Qiao J,Li L,Li B,Wu D,Xiao Q

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2020

Increased Tim-3 expression on TILs during treatment with the Anchored GM-CSF vaccine and anti-PD-1 antibodies is inversely correlated with response in prostate cancer.

Journal of Cancer

Zhang X,Chen H,Li G,Zhou X,Shi Y,Zou F,Chen Y,Gao J,Yang S,Wu S,Long Z

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Loss of Setd4 delays radiation-induced thymic lymphoma in mice.

DNA repair

Feng X,Lu H,Yue J,Schneider N,Liu J,Denzin LK,Chan CS,De S,Shen Z

47-0042 was used in Flow cytometry/Cell sorting to report that conditional Setd4 deletion in adult mice significantly extended the survival of radiation-induced T-lymphoma.

Sat Feb 01 00:00:00 EST 2020

Comparison of rapamycin and methylprednisolone for treating inflammatory muscle disease in a murine model of experimental autoimmune myositis.

Experimental and therapeutic medicine

Kang J,Feng D,Yang F,Tian X,Han W,Jia H

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2020

Effects of CD4⁺ T lymphocytes from ovariectomized mice on bone marrow mesenchymal stem cell proliferation and osteogenic differentiation.

Experimental and therapeutic medicine

Shao BY,Wang L,Yu Y,Chen L,Gan N,Huang WM

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Sun Nov 01 00:00:00 EDT 2020

The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.

Nature communications

Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Sep 17 00:00:00 EDT 2020

Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety.

Journal for immunotherapy of cancer

Ge Y,Wang H,Ren J,Liu W,Chen L,Chen H,Ye J,Dai E,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2020

A novel antibody targeting TIM-3 resulting in receptor internalization for cancer immunotherapy.

Antibody therapeutics

Kuang Z,Li L,Zhang P,Chen B,Wu M,Ni H,Yi S,Zou J,Liu J

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Mechanisms of interleukin 4 mediated increase in efficacy of vaccines against opioid use disorders.

NPJ vaccines

Crouse B,Robinson C,Huseby Kelcher A,Laudenbach M,Abrahante JE,Pravetoni M

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Oct 29 00:00:00 EDT 2020

Mechanisms of interleukin 4 mediated increase in efficacy of vaccines against opioid use disorders.

NPJ vaccines

Crouse B,Robinson C,Huseby Kelcher A,Laudenbach M,Abrahante JE,Pravetoni M

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Oct 29 00:00:00 EDT 2020

CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation.

Frontiers in immunology

Shapiro MR,Yeh WI,Longfield JR,Gallagher J,Infante CM,Wellford S,Posgai AL,Atkinson MA,Campbell-Thompson M,Lieberman SM,Serreze DV,Geurts AM,Chen YG,Brusko TM

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed May 26 00:00:00 EDT 2021

Distinct actions of the fermented beverage kefir on host behaviour, immunity and microbiome gut-brain modules in the mouse.

Microbiome

van de Wouw M,Walsh AM,Crispie F,van Leuven L,Lyte JM,Boehme M,Clarke G,Dinan TG,Cotter PD,Cryan JF

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Mon May 18 00:00:00 EDT 2020

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.

Nature communications

Iske J,Seyda M,Heinbokel T,Maenosono R,Minami K,Nian Y,Quante M,Falk CS,Azuma H,Martin F,Passos JF,Niemann CU,Tchkonia T,Kirkland JL,Elkhal A,Tullius SG

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Aug 27 00:00:00 EDT 2020

Loss of testosterone impairs anti-tumor neutrophil function.

Nature communications

Markman JL,Porritt RA,Wakita D,Lane ME,Martinon D,Noval Rivas M,Luu M,Posadas EM,Crother TR,Arditi M

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Mar 31 00:00:00 EDT 2020

Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration.

Cell reports

Piao W,Xiong Y,Li L,Saxena V,Smith KD,Hippen KL,Paluskievicz C,Willsonshirkey M,Blazar BR,Abdi R,Bromberg JS

47-0042-82 was used in Flow Cytometry to demonstrate the role of regulatory T cells in enhancing leukocyte migration through endothelial barriers.

Tue Jan 28 00:00:00 EST 2020

B Cell Diversification Is Uncoupled from SAP-Mediated Selection Forces in Chronic Germinal Centers within Peyer's Patches.

Cell reports

Biram A,Winter E,Denton AE,Zaretsky I,Dassa B,Bemark M,Linterman MA,Yaari G,Shulman Z

47-0042-82 was used in Flow cytometry/Cell sorting to demonstrate that T cell-derived help to B cells in PPs includes SAP-dependent and SAP-independent functions.

Tue Feb 11 00:00:00 EST 2020

A Commercial Probiotic Induces Tolerogenic and Reduces Pathogenic Responses in Experimental Autoimmune Encephalomyelitis.

Cells

Calvo-Barreiro L,Eixarch H,Ponce-Alonso M,Castillo M,Lebrón-Galán R,Mestre L,Guaza C,Clemente D,Del Campo R,Montalban X,Espejo C

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Apr 07 00:00:00 EDT 2020

Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3⁺ Regulatory T Cells.

Cell reports

Yang YH,Istomine R,Alvarez F,Al-Aubodah TA,Shi XQ,Takano T,Thornton AM,Shevach EM,Zhang J,Piccirillo CA

47-0042-82 was used in Flow Cytometry to show that high salt (HS) drives thymic Treg cells to adopt a T helper type 17 (Th17)-like phenotype and enhances generation of Th17-like induced Treg cells in a SGK1-dependent manner, all the while maintaining suppressive function.

Tue Feb 04 00:00:00 EST 2020

Requirements for the differentiation of innate T-bet^high memory-phenotype CD4⁺ T lymphocytes under steady state.

Nature communications

Kawabe T,Yi J,Kawajiri A,Hilligan K,Fang D,Ishii N,Yamane H,Zhu J,Jankovic D,Kim KS,Trinchieri G,Sher A

47-0042 was used in Flow cytometry/Cell sorting to study whether MP CD4+ T cells are functionally heterogeneous and, if so, what signals specify the differentiation of MP cell subpopulations under homeostatic conditions.

Mon Jul 06 00:00:00 EDT 2020

Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells.

Cell reports

Shin B,Benavides GA,Geng J,Koralov SB,Hu H,Darley-Usmar VM,Harrington LE

47-0042 was used in Flow cytometry/Cell sorting to study the role of mitochondrial oxidative phosphorylation in pathogenic Th17 differentiation.

Tue Feb 11 00:00:00 EST 2020

TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4⁺ T Cells to T_reg.

Cell reports

Dolina JS,Lee J,Griswold RQ,Labarta-Bajo L,Kannan S,Greenbaum JA,Bahia El Idrissi N,Pont MJ,Croft M,Schoenberger SP

47-0042 was used in Flow cytometry/Cell sorting to resolve long-standing questions regarding the conditional requirement for TH amongst pathogens and reveal a remarkable degree of plasticity in the function of CD4+ T cells, which can be quickly converted to Tregin vivo by infection-mediated immune modulation.

Tue Apr 07 00:00:00 EDT 2020

The PD-1 Pathway Regulates Development and Function of Memory CD8⁺ T Cells following Respiratory Viral Infection.

Cell reports

Pauken KE,Godec J,Odorizzi PM,Brown KE,Yates KB,Ngiow SF,Burke KP,Maleri S,Grande SM,Francisco LM,Ali MA,Imam S,Freeman GJ,Haining WN,Wherry EJ,Sharpe AH

47-0042-82 was used in Flow Cytometry to demonstrate that PD-1 signals are needed for optimal memory.

Tue Jun 30 00:00:00 EDT 2020

Axenic Caenorhabditis elegans antigen protects against development of type-1 diabetes in NOD mice.

Journal of translational autoimmunity

Jackson-Thompson BM,Torrero M,Mitre BK,Long J,Packiam M,Mitre E

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.

Nature

Escolano A,Gristick HB,Abernathy ME,Merkenschlager J,Gautam R,Oliveira TY,Pai J,West AP,Barnes CO,Cohen AA,Wang H,Golijanin J,Yost D,Keeffe JR,Wang Z,Zhao P,Yao KH,Bauer J,Nogueira L,Gao H,Voll AV,Montefiori DC,Seaman MS,Gazumyan A,Silva M,McGuire AT,Stamatatos L,Irvine DJ,Wells L,Martin MA,Bjorkman PJ,Nussenzweig MC

47-0042-82 was used in Flow Cytometry to develop an immunogen, RC1, that facilitates the recognition of the variable loop 3 (V3)-glycan patch on the envelope protein of HIV-1 to activate B cells that express precursors of broadly neutralizing antibodies within polyclonal repertoires.

Sat Jun 01 00:00:00 EDT 2019

A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation.

Immunity

Vacchio MS,Ciucci T,Gao Y,Watanabe M,Balmaceno-Criss M,McGinty MT,Huang A,Xiao Q,McConkey C,Zhao Y,Shetty J,Tran B,Pepper M,Vahedi G,Jenkins MK,McGavern DB,Bosselut R

47-0042-82 was used in Flow Cytometry to identify a transcriptional program that links the CD4+ lineage with Tfh differentiation, a limiting factor for efficient B cell responses.

Tue Sep 17 00:00:00 EDT 2019

Cell-intrinsic depletion of Aml1-ETO-expressing pre-leukemic hematopoietic stem cells by K-Ras activating mutation.

Haematologica

Di Genua C,Norfo R,Rodriguez-Meira A,Wen WX,Drissen R,Booth CAG,Povinelli B,Repapi E,Gray N,Carrelha J,Kettyle LM,Jamieson L,Neo WH,Thongjuea S,Nerlov C,Mead AJ

47-0042 was used in Flow cytometry/Cell sorting to study the mechanism behind absence of KRAS signalling mutations in pre-malignant hematopoietic stem cell compartments.

Fri Nov 01 00:00:00 EDT 2019

Clonal copy-number mosaicism in autoreactive T lymphocytes in diabetic NOD mice.

Genome research

Alriyami M,Marchand L,Li Q,Du X,Olivier M,Polychronakos C

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Sun Dec 01 00:00:00 EST 2019

A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia.

JCI insight

Yin M,Baslan T,Walker RL,Zhu YJ,Freeland A,Matsukawa T,Sridharan S,Nussenzweig A,Pruitt SC,Lowe SW,Meltzer PS,Aplan PD

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Dec 05 00:00:00 EST 2019

Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction.

Frontiers in immunology

Fenninger F,Han J,Stanwood SR,Nohara LL,Arora H,Choi KB,Munro L,Pfeifer CG,Shanina I,Horwitz MS,Jefferies WA

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Oct 29 00:00:00 EDT 2020

Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis.

Scientific reports

Brichacek AL,Benkovic SA,Chakraborty S,Nwafor DC,Wang W,Jun S,Dakhlallah D,Geldenhuys WJ,Pinkerton AB,Millán JL,Brown CM

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Dec 11 00:00:00 EST 2019

Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases.

Scientific reports

Park TY,Jang Y,Kim W,Shin J,Toh HT,Kim CH,Yoon HS,Leblanc P,Kim KS

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Oct 29 00:00:00 EDT 2019

Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR.

Nature communications

Zhu H,Bhatt B,Sivaprakasam S,Cai Y,Liu S,Kodeboyina SK,Patel N,Savage NM,Sharma A,Kaufman RJ,Li H,Singh N

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Mar 06 00:00:00 EST 2019

Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis.

Nature communications

Zhang X,Zhang H,Xu C,Li X,Li M,Wu X,Pu W,Zhou B,Wang H,Li D,Ding Q,Ying H,Wang H,Zhang H

47-0042-82 was used in Flow Cytometry to reveal a critical role of Lys376-mediated ubiquitination of RIPK1 in suppressing RIPK1 kinase activity-dependent lethal pathways during embryogenesis and RIPK3-dependent inflammation postnatally.

Fri Sep 13 00:00:00 EDT 2019

ImmGen report: sexual dimorphism in the immune system transcriptome.

Nature communications

Gal-Oz ST,Maier B,Yoshida H,Seddu K,Elbaz N,Czysz C,Zuk O,Stranger BE,Ner-Gaon H,Shay T

47-0042 was used in Flow cytometry/Cell sorting to show transcriptional sexual dimorphism in macrophages.

Fri Sep 20 00:00:00 EDT 2019

Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population.

Cell reports

Leylek R,Alcántara-Hernández M,Lanzar Z,Lüdtke A,Perez OA,Reizis B,Idoyaga J

47-0042 was used in Flow cytometry/Cell sorting to provide a framework for deciphering the function of pDCs and tDCs during diseases, which has the potential to open new avenues for therapeutic design.

Tue Dec 10 00:00:00 EST 2019

Reduction of Global H3K27me³ Enhances HER2/ErbB2 Targeted Therapy.

Cell reports

Hirukawa A,Singh S,Wang J,Rennhack JP,Swiatnicki M,Sanguin-Gendreau V,Zuo D,Daldoul K,Lavoie C,Park M,Andrechek ER,Westbrook TF,Harris LN,Varadan V,Smith HW,Muller WJ

47-0042-82 was used in Flow cytometry/Cell sorting to provide evidence that EZH2 inhibitors promote interferon-driven immune responses that enhance the efficacy of anti-ErbB2 mAbs, suggesting the potential clinical benefit of epigenomic reprogramming by H3K27me3 depletion in Trastuzumab-resistant disease.

Tue Oct 08 00:00:00 EDT 2019

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Cell

Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Jun 28 00:00:00 EDT 2018

T-Cell-Intrinsic Receptor Interacting Protein 2 Regulates Pathogenic T Helper 17 Cell Differentiation.

Immunity

Shimada K,Porritt RA,Markman JL,O'Rourke JG,Wakita D,Noval Rivas M,Ogawa C,Kozhaya L,Martins GA,Unutmaz D,Baloh RH,Crother TR,Chen S,Arditi M

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Nov 20 00:00:00 EST 2018

TCF-1 and HEB cooperate to establish the epigenetic and transcription profiles of CD4⁺CD8⁺ thymocytes.

Nature immunology

Emmanuel AO,Arnovitz S,Haghi L,Mathur PS,Mondal S,Quandt J,Okoreeh MK,Maienschein-Cline M,Khazaie K,Dose M,Gounari F

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Sat Dec 01 00:00:00 EST 2018

Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5.

The Journal of experimental medicine

Buxadé M,Huerga Encabo H,Riera-Borrull M,Quintana-Gallardo L,López-Cotarelo P,Tellechea M,Martínez-Martínez S,Redondo JM,Martín-Caballero J,Flores JM,Bosch E,Rodríguez-Fernández JL,Aramburu J,López-Rodríguez C

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Mon Nov 05 00:00:00 EST 2018

Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation.

The Journal of experimental medicine

Shin B,Kress RL,Kramer PA,Darley-Usmar VM,Bellis SL,Harrington LE

47-0042 was used in Flow cytometry/Cell sorting to indicate that the chronicity of T cell-mediated inflammation is perpetuated by specific effector CD4 T cells with stem-like properties.

Mon Jul 02 00:00:00 EDT 2018

Bryostatin-1 alleviates experimental multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Feb 27 00:00:00 EST 2018

Quantitative Methods for Measuring Repair Rates and Innate-Immune Cell Responses in Wounded Mouse Skin.

Frontiers in immunology

Li Z,Gothard E,Coles MC,Ambler CA

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Mar 27 00:00:00 EDT 2019

Protease-activated receptor-2 signaling through β-arrestin-2 mediates Alternaria alkaline serine protease-induced airway inflammation.

American journal of physiology. Lung cellular and molecular physiology

Yee MC,Nichols HL,Polley D,Saifeddine M,Pal K,Lee K,Wilson EH,Daines MO,Hollenberg MD,Boitano S,DeFea KA

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Sat Dec 01 00:00:00 EST 2018

SunRiSE - measuring translation elongation at single-cell resolution by means of flow cytometry.

Journal of cell science

Argüello RJ,Reverendo M,Mendes A,Camosseto V,Torres AG,Ribas de Pouplana L,van de Pavert SA,Gatti E,Pierre P

47-0042 was used in Flow cytometry/Cell sorting to demonstrate that, in mouse embryonic fibroblasts, eEF2 phosphorylation by eEF2 kinase (eEF2K) mostly affects translation engagement, but has a surprisingly small effect on elongation, except after proteotoxic stress induction.

Thu May 31 00:00:00 EDT 2018

Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice.

Journal of neuroimmunology

Kiyota T,Machhi J,Lu Y,Dyavarshetty B,Nemati M,Yokoyama I,Mosley RL,Gendelman HE

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Fri Jun 15 00:00:00 EDT 2018

Immunological effects of a low-dose cytarabine, aclarubicin and granulocyte-colony stimulating factor priming regimen on a mouse leukemia model.

Oncology letters

Chen J,Yang N,Liu H,Yao H,Wang J,Yang Y,Zhang W

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Sat Sep 01 00:00:00 EDT 2018

Protective function of Bu Shen Huo Xue formula on the immunity of B6AF1 mice with experimental autoimmune premature ovarian failure.

Experimental and therapeutic medicine

Wang P,Lu Y,Chen S,Chen Y,Hu C,Zuo Y

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Sun Apr 01 00:00:00 EDT 2018

Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene.

Nature communications

Kojo S,Yasmin N,Muroi S,Tenno M,Taniuchi I

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Sep 05 00:00:00 EDT 2018

Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.

Nature communications

Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Nov 08 00:00:00 EST 2018

Rap1 deficiency-provoked paracrine dysfunction impairs immunosuppressive potency of mesenchymal stem cells in allograft rejection of heart transplantation.

Cell death & disease

Ding Y,Liang X,Zhang Y,Yi L,Shum HC,Chen Q,Chan BP,Fan H,Liu Z,Tergaonkar V,Qi Z,Tse HF,Lian Q

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Mar 07 00:00:00 EST 2018

Adrenal hormones mediate disease tolerance in malaria.

Nature communications

Vandermosten L,Pham TT,Knoops S,De Geest C,Lays N,Van der Molen K,Kenyon CJ,Verma M,Chapman KE,Schuit F,De Bosscher K,Opdenakker G,Van den Steen PE

47-0042 was used in Flow cytometry/Cell sorting to identify the crucial role of adrenal hormones in tolerance of malaria.

Tue Oct 30 00:00:00 EDT 2018

Extremely strong infiltration of WT1-specific CTLs into mouse tumor by the combination vaccine with WT1-specific CTL and helper peptides.

Oncotarget

Nakata J,Nakajima H,Hayashibara H,Imafuku K,Morimoto S,Fujiki F,Motooka D,Okuzaki D,Hasegawa K,Hosen N,Tsuboi A,Oka Y,Kumanogoh A,Oji Y,Sugiyama H

47-0042 was used in Flow cytometry to provide the concept that in the clinical setting, combination vaccine of WT1-specific cytotoxic T lymphocyte and helper peptides would be more advantageous than the CTL peptide vaccine alone.

Tue Nov 13 00:00:00 EST 2018

Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment.

The Journal of clinical investigation

Wang YT,Chen J,Chang CW,Jen J,Huang TY,Chen CM,Shen R,Liang SY,Cheng IC,Yang SC,Lai WW,Cheng KH,Hsieh TS,Lai MZ,Cheng HC,Wang YC,Chen RH

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.

The Journal of clinical investigation

Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.

The Journal of experimental medicine

Schwartz C,Khan AR,Floudas A,Saunders SP,Hams E,Rodewald HR,McKenzie ANJ,Fallon PG

47-0042 was used in Flow cytometry/Cell sorting to study how group 2 innate lymphoid cells regulate adaptive Th2 cell functions.

Mon Sep 04 00:00:00 EDT 2017

IL-36 Signaling Facilitates Activation of the NLRP3 Inflammasome and IL-23/IL-17 Axis in Renal Inflammation and Fibrosis.

Journal of the American Society of Nephrology : JASN

Chi HH,Hua KF,Lin YC,Chu CL,Hsieh CY,Hsu YJ,Ka SM,Tsai YL,Liu FC,Chen A

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Sat Jul 01 00:00:00 EDT 2017

Prenatal Administration of Betamethasone Causes Changes in the T Cell Receptor Repertoire Influencing Development of Autoimmunity.

Frontiers in immunology

Gieras A,Gehbauer C,Perna-Barrull D,Engler JB,Diepenbruck I,Glau L,Joosse SA,Kersten N,Klinge S,Mittrücker HW,Friese MA,Vives-Pi M,Tolosa E

47-0042 was used in Flow cytometry/Cell sorting to demonstrate that prenatal administration of betamethasone causes changes in the T cell receptor repertoire influencing development of autoimmunity.

Wed Nov 20 00:00:00 EST 2019

Vaccine-induced Th17 cells are established as resident memory cells in the lung and promote local IgA responses.

Mucosal immunology

Christensen D,Mortensen R,Rosenkrands I,Dietrich J,Andersen P

47-0042 was used in Flow cytometry/Cell sorting to demonstrate that subcutaneous priming with a recombinant antigen in a T helper (Th)17-inducing adjuvant followed by airway boosting promotes high and sustained levels of IgA in the lungs.

Sun Jan 01 00:00:00 EST 2017

IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury.

Frontiers in neurology

Gao W,Li F,Zhou Z,Xu X,Wu Y,Zhou S,Yin D,Sun D,Xiong J,Jiang R,Zhang J

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Huai Qi Huang corrects the balance of Th1/Th2 and Treg/Th17 in an ovalbumin-induced asthma mouse model.

Bioscience reports

Liang P,Peng S,Zhang M,Ma Y,Zhen X,Li H

47-0042 was used in Flow cytometry/Cell sorting to determine the immunoregulatory effects of Huai Qi Huang on regulatory and helper T cell balance in ovalbumin induced asthma.

Fri Dec 22 00:00:00 EST 2017

Discrimination of the heterogeneity of bone marrow‑derived dendritic cells.

Molecular medicine reports

Wang J,Dai X,Hsu C,Ming C,He Y,Zhang J,Wei L,Zhou P,Wang CY,Yang J,Gong N

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Nov 01 00:00:00 EDT 2017

Immunological effects of vaccines combined with granulocyte colony-stimulating factor on a murine WEHI-3 leukemia model.

Oncology letters

Chen J,Zhang M,Zhou F,Wang J,Niu B,Zhang W

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

Effect of follicular helper T cells on the pathogenesis of asthma.

Experimental and therapeutic medicine

Ma X,Sun Z,Zhai P,Yu W,Wang T,Li F,Ding J

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.

JCI insight

Le Saout C,Luckey MA,Villarino AV,Smith M,Hasley RB,Myers TG,Imamichi H,Park JH,O'Shea JJ,Lane HC,Catalfamo M

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Nov 16 00:00:00 EST 2017

Extrafollicular CD4⁺ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.

Nature communications

Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

Extrafollicular CD4⁺ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.

Nature communications

Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

Batf3-dependent CD8α⁺ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.

EBioMedicine

Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

Fractional Laser Releases Tumor-Associated Antigens in Poorly Immunogenic Tumor and Induces Systemic Immunity.

Scientific reports

Kawakubo M,Cunningham TJ,Demehri S,Manstein D

47-0042 was used in Flow cytometry/Cell sorting to assess the utility of ablative fractional photothermolysis for treating oncological indications.

Fri Oct 06 00:00:00 EDT 2017

Splenic glucocorticoid resistance following psychosocial stress requires physical injury.

Scientific reports

Foertsch S,Füchsl AM,Faller SD,Hölzer H,Langgartner D,Messmann J,Strauß G,Reber SO

47-0042 was used in Flow cytometry/Cell sorting to study the importance of wounding in the mechanisms underlying splenic immune activation and glucocorticoid resistance following social stress in male mice.

Thu Nov 16 00:00:00 EST 2017

Isolation of cell type-specific apoptotic bodies by fluorescence-activated cell sorting.

Scientific reports

Atkin-Smith GK,Paone S,Zanker DJ,Duan M,Phan TK,Chen W,Hulett MD,Poon IK

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Fri Jan 06 00:00:00 EST 2017

Fractional laser exposure induces neutrophil infiltration (N1 phenotype) into the tumor and stimulates systemic anti-tumor immune response.

PloS one

Kawakubo M,Demehri S,Manstein D

47-0042 was used in Flow cytometry/Cell sorting to explore the utility of ablative fractional photothermolysis in treating oncological indications, including induction of local tumour regression and inducing anti-tumour immunity.

Fri Oct 13 00:00:00 EDT 2017

Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade.

Cell

Benci JL,Xu B,Qiu Y,Wu TJ,Dada H,Twyman-Saint Victor C,Cucolo L,Lee DSM,Pauken KE,Huang AC,Gangadhar TC,Amaravadi RK,Schuchter LM,Feldman MD,Ishwaran H,Vonderheide RH,Maity A,Wherry EJ,Minn AJ

47-0042 was used in Flow cytometry/Cell sorting to demonstrate that prolonged interferon signalling orchestrates PDL1-dependent and PDL1-independent resistance to immune checkpoint blockade and to combinations such as radiation plus anti-CTLA4.

Thu Dec 01 00:00:00 EST 2016

Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission.

Immunity

Tian Y,Kuo CF,Akbari O,Ou JH

47-0042 was used in Flow cytometry/Cell sorting to show in mice, that maternal hepatitis B virus (HBV) impairs CD8(+) T cell responses to HBV in her offspring, resulting in HBV persistence.

Tue May 17 00:00:00 EDT 2016

CD69 controls the uptake of L-tryptophan through LAT1-CD98 and AhR-dependent secretion of IL-22 in psoriasis.

Nature immunology

Cibrian D,Saiz ML,de la Fuente H,Sánchez-Díaz R,Moreno-Gonzalo O,Jorge I,Ferrarini A,Vázquez J,Punzón C,Fresno M,Vicente-Manzanares M,Daudén E,Fernández-Salguero PM,Martín P,Sánchez-Madrid F

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

Oligodendrocyte death results in immune-mediated CNS demyelination.

Nature neuroscience

Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.

The Journal of experimental medicine

Drennan MB,Govindarajan S,Verheugen E,Coquet JM,Staal J,McGuire C,Taghon T,Leclercq G,Beyaert R,van Loo G,Lambrecht BN,Elewaut D

47-0042 was used in Flow cytometry/Cell sorting to show that negative regulation of TCR signalling during NKT development controls the differentiation and survival of NKT1 and NKT2 cells.

Mon Sep 19 00:00:00 EDT 2016

STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides.

Clinical cancer research : an official journal of the American Association for Cancer Research

Vieyra-Garcia PA,Wei T,Naym DG,Fredholm S,Fink-Puches R,Cerroni L,Odum N,O'Malley JT,Gniadecki R,Wolf P

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Fri Jul 01 00:00:00 EDT 2016

CD4 T Helper Cells Instruct Lymphopenia-Induced Memory-Like CD8 T Cells for Control of Acute LCMV Infection.

Frontiers in immunology

Schmitt ME,Sitte S,Voehringer D

47-0042 was used in Flow cytometry/Cell sorting to determine whether memory-like T cells can efficiently respond to foreign antigen and participate in antiviral immunity.

Wed Nov 20 00:00:00 EST 2019

Helios Controls a Limited Subset of Regulatory T Cell Functions.

Journal of immunology (Baltimore, Md. : 1950)

Sebastian M,Lopez-Ocasio M,Metidji A,Rieder SA,Shevach EM,Thornton AM

47-0042 was used in Flow cytometry/Cell sorting to determine the beneficial effects of the transcription factor, Helios, for Treg maintenance, differentiation, and survival.

Fri Jan 01 00:00:00 EST 2016

Contamination of DNase Preparations Confounds Analysis of the Role of DNA in Alum-Adjuvanted Vaccines.

Journal of immunology (Baltimore, Md. : 1950)

Noges LE,White J,Cambier JC,Kappler JW,Marrack P

47-0042 was used in Flow cytometry/Cell sorting to investigate the contribution of host DNA released at the site of vaccine injection to the adjuvant activity of alum.

Mon Aug 15 00:00:00 EDT 2016

Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model.

Molecular medicine reports

Yue Y,Li P,Song N,Li B,Li Z,Guo Y,Zhang W,Wei MQ,Gai Z,Meng H,Wang J,Qin L

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells.

Nature communications

Baptista MA,Keszei M,Oliveira M,Sunahara KK,Andersson J,Dahlberg CI,Worth AJ,Liedén A,Kuo IC,Wallin RP,Snapper SB,Eidsmo L,Scheynius A,Karlsson MC,Bouma G,Burns SO,Forsell MN,Thrasher AJ,Nylén S,Westerberg LS

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Mon Jul 18 00:00:00 EDT 2016

SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors.

Oncotarget

Xue W,Brentville VA,Symonds P,Cook KW,Yagita H,Metheringham RL,Durrant LG

47-0042 was used in Flow cytometry/Cell sorting to investigate the anti-tumour effect of a huIgG1 antibody DNA vaccine and PD-1 blockade.

Tue Dec 13 00:00:00 EST 2016

Sequencing and cloning of antigen-specific antibodies from mouse memory B cells.

Nature protocols

von Boehmer L,Liu C,Ackerman S,Gitlin AD,Wang Q,Gazumyan A,Nussenzweig MC

47-0042-82 was used in Flow cytometry/Cell sorting to sequence and clone the variable antibody region of single antigen-specific mouse memory B cells for antibody production.

Sat Oct 01 00:00:00 EDT 2016

Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.

eLife

Allison KA,Sajti E,Collier JG,Gosselin D,Troutman TD,Stone EL,Hedrick SM,Glass CK

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Mon Jul 04 00:00:00 EDT 2016

Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner.

PloS one

Watanabe N,Kaminuma O,Kitamura N,Hiroi T

47-0042 was used in Flow cytometry/Cell sorting to study whether Th17 and Tregs that promote and suppress inflammatory responses, respectively, work with or against each other in immune reactions, showing that cotransfer of Th17 and induced Tregs led to increased inflammation, and blockage of CTLA4 led to abrogation of this effect.

Mon Aug 01 00:00:00 EDT 2016

A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer.

Oncotarget

Yong CS,John LB,Devaud C,Prince MH,Johnstone RW,Trapani JA,Darcy PK,Kershaw MH

47-0042 was used in Flow cytometry/Cell sorting to characterise the function of leukocytes from transgenic mice expressing a chimeric antigen receptor under the control of vav, and determine the ability of these mice to respond to ERB-expressing tumours.

Tue Jun 07 00:00:00 EDT 2016

Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator.

Nature communications

Zhu ML,Bakhru P,Conley B,Nelson JS,Free M,Martin A,Starmer J,Wilson EM,Su MA

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Apr 13 00:00:00 EDT 2016

Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma.

Oncoimmunology

Vandenberk L,Garg AD,Verschuere T,Koks C,Belmans J,Beullens M,Agostinis P,De Vleeschouwer S,Van Gool SW

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2016

Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination.

Scientific reports

Stifter K,Schuster C,Schlosser M,Boehm BO,Schirmbeck R

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Mon Jul 11 00:00:00 EDT 2016

IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.

Nature immunology

Basu R,Whitley SK,Bhaumik S,Zindl CL,Schoeb TR,Benveniste EN,Pear WS,Hatton RD,Weaver CT

47-0042 was used in Flow cytometry/Cell sorting to assess the ability of IL-1 to override retinoic acid-mediated expression of the transcription factor Foxp3 and induce protective TH17 cell responses.

Sun Mar 01 00:00:00 EST 2015

Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.

Cardiovascular research

Wan W,Liu Q,Lionakis MS,Marino AP,Anderson SA,Swamydas M,Murphy PM

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2015

Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.

Frontiers in immunology

Vogel AJ,Brown DM

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Fri Jul 10 00:00:00 EDT 2015

A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells.

Cancer biology & therapy

Kawahara M,Takaku H

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Mon Sep 12 00:00:00 EDT 2016

Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.

Human vaccines & immunotherapeutics

Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Fri Mar 11 00:00:00 EST 2016

Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.

Gene therapy

Rodriguez-Peña AB,Gomez-Rodriguez J,Kortum RL,Palmer DC,Yu Z,Guittard GC,Wohlfert EA,Silver PB,Misplon JA,Sommers CL,Feigenbaum L,Epstein SL,Caspi RR,Belkaid Y,Restifo NP,Samelson LE,Balagopalan L

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2015

Yersinia pestis targets neutrophils via complement receptor 3.

Cellular microbiology

Merritt PM,Nero T,Bohman L,Felek S,Krukonis ES,Marketon MM

47-0042 was used in Flow cytometry/Cell sorting to identify the factors involved in the targeting of murine splenocytes by Yersinia pestis.

Fri May 01 00:00:00 EDT 2015

Limited miR-17-92 overexpression drives hematologic malignancies.

Leukemia research

Danielson LS,Reavie L,Coussens M,Davalos V,Castillo-Martin M,Guijarro MV,Coffre M,Cordon-Cardo C,Aifantis I,Ibrahim S,Liu C,Koralov SB,Hernando E

47-0042 was used in Flow cytometry/Cell sorting to show limited miR-17-92 overexpression can drive hematologic malignancies.

Sun Mar 01 00:00:00 EST 2015

Recombinant adeno-vaccine expressing enterovirus 71-like particles against hand, foot, and mouth disease.

PLoS neglected tropical diseases

Tsou YL,Lin YW,Shao HY,Yu SL,Wu SR,Lin HY,Liu CC,Huang C,Chong P,Chow YH

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Sep 15 00:00:00 EDT 2015

Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation.

eLife

He L,Zhang Y,Ma G,Tan P,Li Z,Zang S,Wu X,Jing J,Fang S,Zhou L,Wang Y,Huang Y,Hogan PG,Han G,Zhou Y

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Dec 08 00:00:00 EST 2015

Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors.

Oncotarget

Colbeck EJ,Hindley JP,Smart K,Jones E,Bloom A,Bridgeman H,McPherson RC,Turner DG,Ladell K,Price DA,O'Connor RA,Anderton SM,Godkin AJ,Gallimore AM

47-0042 was used in Flow cytometry/Cell sorting to study the enrichment of tumor-infiltrating Treg populations and assess the role of IL-2 in pertubation of Treg frequencies in tumors.

Tue Sep 22 00:00:00 EDT 2015

Expression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic Mice.

PloS one

Yong CS,Westwood JA,Schröder J,Papenfuss AT,von Scheidt B,Moeller M,Devaud C,Darcy PK,Kershaw MH

47-0042 was used in Flow cytometry/Cell sorting to generate a mouse model expressing chimeric antigen receptors (CARs) specific for a tumour antigen under a pan-hematopoietic promoter.

Wed Jun 08 00:00:00 EDT 2016

In vivo RNA interference screens identify regulators of antiviral CD4(+) and CD8(+) T cell differentiation.

Immunity

Chen R,Bélanger S,Frederick MA,Li B,Johnston RJ,Xiao N,Liu YC,Sharma S,Peters B,Rao A,Crotty S,Pipkin ME

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Aug 21 00:00:00 EDT 2014

Tissues in different anatomical sites can sculpt and vary the tumor microenvironment to affect responses to therapy.

Molecular therapy : the journal of the American Society of Gene Therapy

Devaud C,Westwood JA,John LB,Flynn JK,Paquet-Fifield S,Duong CP,Yong CS,Pegram HJ,Stacker SA,Achen MG,Stewart TJ,Snyder LA,Teng MW,Smyth MJ,Darcy PK,Kershaw MH

47-0042 was used in Flow cytometry/Cell sorting to explore the relationship between tumour microenvironments and efficacy of immunotherapy.

Wed Jan 01 00:00:00 EST 2014

Intranasal vaccination promotes detrimental Th17-mediated immunity against influenza infection.

PLoS pathogens

Maroof A,Yorgensen YM,Li Y,Evans JT

47-0042 was used in Flow cytometry/Cell sorting to highlight the importance of both route of vaccination and adjuvant selection in vaccine development.

Wed Jan 01 00:00:00 EST 2014

TLR2 engagement on CD4(+) T cells enhances effector functions and protective responses to Mycobacterium tuberculosis.

European journal of immunology

Reba SM,Li Q,Onwuzulike S,Ding X,Karim AF,Hernandez Y,Fulton SA,Harding CV,Lancioni CL,Nagy N,Rodriguez ME,Wearsch PA,Rojas RE

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Differential requirement for CCR4 and CCR7 during the development of innate and adaptive αβT cells in the adult thymus.

Journal of immunology (Baltimore, Md. : 1950)

Cowan JE,McCarthy NI,Parnell SM,White AJ,Bacon A,Serge A,Irla M,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G

47-0042 was used in Flow cytometry/Cell sorting to identify novel roles for CCR7 during intrathymic T cell development, highlighting its importance in enabling multiple αβT cell lineages to access the thymic medulla.

Fri Aug 01 00:00:00 EDT 2014

Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface.

PloS one

Habbeddine M,Verbeke P,Karaz S,Bobé P,Kanellopoulos-Langevin C

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Jun 10 00:00:00 EDT 2015

The efficacy of tumor debulking surgery is improved by adjuvant immunotherapy using imiquimod and anti-CD40.

BMC cancer

Khong A,Cleaver AL,Fahmi Alatas M,Wylie BC,Connor T,Fisher SA,Broomfield S,Lesterhuis WJ,Currie AJ,Lake RA,Robinson BW

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Wed Dec 17 00:00:00 EST 2014

P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica.

PloS one

Monção-Ribeiro LC,Faffe DS,Santana PT,Vieira FS,da Graça CL,Marques-da-Silva C,Machado MN,Caruso-Neves C,Zin WA,Borojevic R,Takiya CM,Coutinho-Silva R

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Sep 17 00:00:00 EDT 2015

Foxp3 expression in macrophages associated with RENCA tumors in mice.

PloS one

Devaud C,Yong CS,John LB,Westwood JA,Duong CP,House CM,Denoyer D,Li J,Darcy PK,Kershaw MH

47-0042 was used in Flow cytometry/Cell sorting to study how tumour-associated macrophages could express Foxp3.

Mon Nov 16 00:00:00 EST 2015

Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium.

The Journal of experimental medicine

Schreiber HA,Loschko J,Karssemeijer RA,Escolano A,Meredith MM,Mucida D,Guermonprez P,Nussenzweig MC

47-0042 was used in Flow cytometry/Cell sorting to assess the effect of selective depletion of monocytes and macrophages on immune responses to a bacterial pathogen.

Mon Sep 23 00:00:00 EDT 2013

The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development.

The Journal of experimental medicine

Cowan JE,Parnell SM,Nakamura K,Caamano JH,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G

47-0042 was used in Flow cytometry/Cell sorting to demonstrate a differential requirement for the thymic medulla in relation to CD4 conventional and Foxp3(+) thymocyte lineages.

Mon Apr 08 00:00:00 EDT 2013

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages.

The Journal of experimental medicine

Molofsky AB,Nussbaum JC,Liang HE,Van Dyken SJ,Cheng LE,Mohapatra A,Chawla A,Locksley RM

47-0042 was used in Flow cytometry/Cell sorting to study how ILC2s are resident in visceral adipose tissue and promote eosinophils and alternatively activated macrophages, implicated in metabolic homeostasis.

Mon Mar 11 00:00:00 EDT 2013

Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.

Cardiovascular research

Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2013

Peripheral elevation of TNF-α leads to early synaptic abnormalities in the mouse somatosensory cortex in experimental autoimmune encephalomyelitis.

Proceedings of the National Academy of Sciences of the United States of America

Yang G,Parkhurst CN,Hayes S,Gan WB

47-0042 was used in Flow cytometry/Cell sorting to examine the effect of inflammation and cytokine elevation on synaptic connections in the primary somatosensory cortex in a mouse model of EAE.

Tue Jun 18 00:00:00 EDT 2013

Tracking antigen-specific CD4+ T cells throughout the course of chronic Leishmania major infection in resistant mice.

European journal of immunology

Pagán AJ,Peters NC,Debrabant A,Ribeiro-Gomes F,Pepper M,Karp CL,Jenkins MK,Sacks DL

47-0042 was used in Flow cytometry/Cell sorting to study parasite-specific primary CD4(+) T-cell responses to L. major in mice resistant to infection.

Fri Feb 01 00:00:00 EST 2013

A new immuno-, dystrophin-deficient model, the NSG-mdx(4Cv) mouse, provides evidence for functional improvement following allogeneic satellite cell transplantation.

Stem cells (Dayton, Ohio)

Arpke RW,Darabi R,Mader TL,Zhang Y,Toyama A,Lonetree CL,Nash N,Lowe DA,Perlingeiro RC,Kyba M

47-0042 was used in Flow cytometry/Cell sorting to highlight the potency of satellite cells to improve muscle function and the utility of the NSG-mdx(4Cv) model for studies on muscle regeneration.

Thu Aug 01 00:00:00 EDT 2013

Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling.

The American journal of pathology

Guijarro MV,Dahiya S,Danielson LS,Segura MF,Vales-Lara FM,Menendez S,Popiolek D,Mittal K,Wei JJ,Zavadil J,Cordon-Cardo C,Pandolfi PP,Hernando E

47-0042 was used in Flow cytometry/Cell sorting to elucidate the mechanisms driving cytogenetically complex sarcoma development.

Sat Jun 01 00:00:00 EDT 2013

MHC class II expression in human basophils: induction and lack of functional significance.

PloS one

Voskamp AL,Prickett SR,Mackay F,Rolland JM,O'Hehir RE

47-0042 was used in Flow cytometry/Cell sorting to determine the antigen-presenting abilities of basophils and their role in initiating a Th2 phenotype.

Mon Sep 29 00:00:00 EDT 2014

Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.

PloS one

Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Thu Jul 31 00:00:00 EDT 2014

Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells.

PloS one

Xiong H,Maraver A,Latkowski JA,Henderson T,Schlessinger K,Ding Y,Shen J,Tadokoro CE,Lafaille JJ

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Mon Feb 23 00:00:00 EST 2015

A novel function of IL-2: chemokine/chemoattractant/retention receptor genes induction in Th subsets for skin and lung inflammation.

Journal of autoimmunity

Sharma R,Sung SS,Gaskin F,Fu SM,Ju ST

47-0042 was used in Flow cytometry/Cell sorting to investigate the use of IL-2 as a powerful Th1 cytokine and inducer of retention receptor genes in Th subsets for skin and lung inflammation.

Fri Jun 01 00:00:00 EDT 2012

Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis.

PLoS pathogens

Lionakis MS,Fischer BG,Lim JK,Swamydas M,Wan W,Richard Lee CC,Cohen JI,Scheinberg P,Gao JL,Murphy PM

47-0042 was used in Flow cytometry/Cell sorting to show that mice lacking the chemokine receptor Ccr1 have improved renal function and survival without affecting the tissue fungal burden.

Mon Dec 17 00:00:00 EST 2012

Arthritogenic self-reactive CD4+ T cells acquire an FR4hiCD73hi anergic state in the presence of Foxp3+ regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Martinez RJ,Zhang N,Thomas SR,Nandiwada SL,Jenkins MK,Binstadt BA,Mueller DL

47-0042 was used in Flow cytometry/Cell sorting to suggest that autoimmune arthritis develops in the setting of lymphopenia when Foxp3(+)CD4(+) regulatory T cells are insufficient to functionally inactivate all autoreactive CD4(+) T cells that encounter self-Ag.

Sun Jan 01 00:00:00 EST 2012

CD28 promotes CD4+ T cell clonal expansion during infection independently of its YMNM and PYAP motifs.

Journal of immunology (Baltimore, Md. : 1950)

Pagán AJ,Pepper M,Chu HH,Green JM,Jenkins MK

47-0042 was used in Flow cytometry/Cell sorting to track polyclonal peptide:MHCII-specific CD4+ T cells in vivo, in mice with mutations in two sites within the cytoplasmic tail of CD28.

Sat Sep 15 00:00:00 EDT 2012

Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model.

Vaccine

Goicochea MA,Zapata JC,Bryant J,Davis H,Salvato MS,Lukashevich IS

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Feb 14 00:00:00 EST 2012

The stalk domain and the glycosylation status of the activating natural killer cell receptor NKp30 are important for ligand binding.

The Journal of biological chemistry

Hartmann J,Tran TV,Kaudeer J,Oberle K,Herrmann J,Quagliano I,Abel T,Cohnen A,Gatterdam V,Jacobs A,Wollscheid B,Tampé R,Watzl C,Diefenbach A,Koch J

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Fri Sep 07 00:00:00 EDT 2012

Urea amidolyase (DUR1,2) contributes to virulence and kidney pathogenesis of Candida albicans.

PloS one

Navarathna DH,Lionakis MS,Lizak MJ,Munasinghe J,Nickerson KW,Roberts DD

47-0042 was used in Flow cytometry/Cell sorting to demonstrate that Dur1,2p is important for kidney colonisation during disseminated candidiasis and contributes to subsequent renal failure.

Tue Aug 26 00:00:00 EDT 2014

SH2D2A modulates T cell mediated protection to a B cell derived tumor in transgenic mice.

PloS one

Berge T,Grønningsæter IH,Lorvik KB,Abrahamsen G,Granum S,Sundvold-Gjerstad V,Corthay A,Bogen B,Spurkland A

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Tue Aug 26 00:00:00 EDT 2014

Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.

Immunity

Wuerzberger-Davis SM,Chen Y,Yang DT,Kearns JD,Bates PW,Lynch C,Ladell NC,Yu M,Podd A,Zeng H,Huang TT,Wen R,Hoffmann A,Wang D,Miyamoto S

Published figure using CD4 monoclonal antibody (Product # 47-0042-82) in Flow Cytometry

Fri Feb 25 00:00:00 EST 2011

A critical role for SOCS3 in innate resistance to Toxoplasma gondii.

Cell host & microbe

Whitmarsh RJ,Gray CM,Gregg B,Christian DA,May MJ,Murray PJ,Hunter CA

47-0042 was used in Flow cytometry/Cell sorting to study the role of SOCS3 in suppressing IL-6 signalling during immune responses to T. gondii infection.

Thu Sep 15 00:00:00 EDT 2011

A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells.

Nature immunology

Quann EJ,Liu X,Altan-Bonnet G,Huse M

47-0042 was used in Flow cytometry/Cell sorting to investigate the mechanisms that couple diacylglycerol to the microtubule-organising center.

Sun May 22 00:00:00 EDT 2011

Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity.

Nature immunology

Liang HE,Reinhardt RL,Bando JK,Sullivan BM,Ho IC,Locksley RM

47-0042 was used in Flow cytometry/Cell sorting to assess the temporal and spatial production of IL-4 and IL-13 in vivo.

Sun Dec 04 00:00:00 EST 2011

Organ-specific innate immune responses in a mouse model of invasive candidiasis.

Journal of innate immunity

Lionakis MS,Lim JK,Lee CC,Murphy PM

47-0042 was used in Flow cytometry/Cell sorting to provide the first detailed analysis of leukocyte subsets accumulating in different target organs during invasive candidiasis.

Fri Jun 17 00:00:00 EDT 2011

Ly49D-mediated ITAM signaling in immature thymocytes impairs development by bypassing the pre-TCR checkpoint.

Journal of immunology (Baltimore, Md. : 1950)

Merck E,Lees RK,Voyle RB,Held W,MacDonald HR

47-0042 was used in Flow cytometry/Cell sorting to investigate the role of Ly49D-mediated ITAM signaling, showing that it impairs development by bypassing the pre-TCR checkpoint.

Fri Jul 01 00:00:00 EDT 2011

B cell-specific expression of B7-2 is required for follicular Th cell function in response to vaccinia virus.

Journal of immunology (Baltimore, Md. : 1950)

Salek-Ardakani S,Choi YS,Rafii-El-Idrissi Benhnia M,Flynn R,Arens R,Shoenberger S,Crotty S,Croft M,Salek-Ardakani S

47-0042 was used in Flow cytometry/Cell sorting to determine the effects of B7-1 and B7-2 interactions on follicular Th (T(FH)) cell function in response to vaccinia virus.

Sun May 01 00:00:00 EDT 2011

IL-2-controlled expression of multiple T cell trafficking genes and Th2 cytokines in the regulatory T cell-deficient scurfy mice: implication to multiorgan inflammation and control of skin and lung inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Sharma R,Sharma PR,Kim YC,Leitinger N,Lee JK,Fu SM,Ju ST

47-0042 was used in Flow cytometry/Cell sorting to investigate the role of IL2 in scurfy.

Sat Jan 15 00:00:00 EST 2011

Expression and role of FLT3 in regulation of the earliest stage of normal granulocyte-monocyte progenitor development.

Blood

Böiers C,Buza-Vidas N,Jensen CT,Pronk CJ,Kharazi S,Wittmann L,Sitnicka E,Hultquist A,Jacobsen SE

47-0042 was used in Flow cytometry/Cell sorting to investigate the role of FLT3 in early granulocyte-monocyte progenitors (GMPs), showing that most GMPs are derived from FLT3-expressing progenitors.

Thu Jun 17 00:00:00 EDT 2010

IL-10 regulates movement of intestinally derived CD4+ T cells to the liver.

Journal of immunology (Baltimore, Md. : 1950)

Bliss SK,Bliss SP,Beiting DP,Alcaraz A,Appleton JA

Fri Jun 15 00:00:00 EDT 2007

Bioinformatics

Protein Aliases: CD4; CD4 antigen p55; cd4a; fCD4; Leu-3; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4)

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Gene Aliases: Cd4; L3T4; Ly-4

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UniProt ID: (Mouse) P06332

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Entrez Gene ID: (Mouse) 12504

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Function(s)

glycoprotein binding protein binding zinc ion binding coreceptor activity enzyme binding protein kinase binding protein homodimerization activity

Process(es)

cytokine production immune system process induction by virus of host cell-cell fusion immune response cell adhesion cell surface receptor signaling pathway T cell differentiation maintenance of protein location in cell T cell activation T cell selection protein palmitoleylation positive regulation of protein kinase activity positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-negative bacterium positive regulation of calcium-mediated signaling regulation of T cell activation positive regulation of T cell activation

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CD4 Monoclonal Antibody (RM4-5), APC-eFluor™ 780, eBioscience™

CD4 Antibody (47-0042-82) in Flow

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47-0042-82

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