Product References
Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell, macrophage, and B cell function.
Cancer cell
Veatch JR,Lee SM,Shasha C,Singhi N,Szeto JL,Moshiri AS,Kim TS,Smythe K,Kong P,Fitzgibbon M,Jesernig B,Bhatia S,Tykodi SS,Hall ET,Byrd DR,Thompson JA,Pillarisetty VG,Duhen T,McGarry Houghton A,Newell E,Gottardo R,Riddell SR
48-4776-42 was used in Immunocytochemistry to identify phenotypes and functional correlates of tumor-specific CD4+ T cells in melanoma and suggest the possibility of using such cells to modify the tumor microenvironment.
Mon Apr 11 00:00:00 EDT 2022
Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung.
The Journal of clinical investigation
Ogongo P,Tezera LB,Ardain A,Nhamoyebonde S,Ramsuran D,Singh A,Ng'oepe A,Karim F,Naidoo T,Khan K,Dullabh KJ,Fehlings M,Lee BH,Nardin A,Lindestam Arlehamn CS,Sette A,Behar SM,Steyn AJ,Madansein R,Kløverpris HN,Elkington PT,Leslie A
48-4776-42 was used in Flow Cytometry to examine M. tuberculosis-specific lung tissue-resident memory T cells from humans.
Mon May 17 00:00:00 EDT 2021
People critically ill with COVID-19 exhibit peripheral immune profiles predictive of mortality and reflective of SARS-CoV-2 lung viral burden.
Cell reports. Medicine
Cillo AR,Somasundaram A,Shan F,Cardello C,Workman CJ,Kitsios GD,Ruffin AT,Kunning S,Lampenfeld C,Onkar S,Grebinoski S,Deshmukh G,Methe B,Liu C,Nambulli S,Andrews LP,Duprex WP,Joglekar AV,Benos PV,Ray P,Ray A,McVerry BJ,Zhang Y,Lee JS,Das J,Singh H,Morris A,Bruno TC,Vignali DAA
48-4776-42 was used in Flow cytometry/Cell sorting to present high-dimensional profiling of blood and respiratory samples from people with severe COVID-19 to examine the association between cell-linked molecular features and mortality outcomes.
Tue Dec 21 00:00:00 EST 2021
Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer.
Immunity
Cillo AR,Kürten CHL,Tabib T,Qi Z,Onkar S,Wang T,Liu A,Duvvuri U,Kim S,Soose RJ,Oesterreich S,Chen W,Lafyatis R,Bruno TC,Ferris RL,Vignali DAA
48-4776 was used in Flow cytometry/Cell sorting to assess the transcriptional profiles of 131,224 single cells from peripheral and intra-tumoral immune populations from patients with HPV- and HPV+ HNSCC and healthy donors.
Tue Jan 14 00:00:00 EST 2020
A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma.
Nature immunology
Harb H,Stephen-Victor E,Crestani E,Benamar M,Massoud A,Cui Y,Charbonnier LM,Arbag S,Baris S,Cunnigham A,Leyva-Castillo JM,Geha RS,Mousavi AJ,Guennewig B,Schmitz-Abe K,Sioutas C,Phipatanakul W,Chatila TA
48-4776 was used in Flow cytometry/Cell sorting to find that interleukin-6- and STAT3 transcription factor-dependent upregulation of Notch4 receptor on lung tissue regulatory T (Treg) cells is necessary for allergens and particulate matter pollutants to promote airway inflammation.
Sun Nov 01 00:00:00 EDT 2020
Clusters of Tolerogenic B Cells Feature in the Dynamic Immunological Landscape of the Pregnant Uterus.
Cell reports
Benner M,Feyaerts D,García CC,Inci N,López SC,Fasse E,Shadmanfar W,van der Heijden OWH,Gorris MAJ,Joosten I,Ferwerda G,van der Molen RG
48-4776-42 was used in Flow Cytometry to suggest a role for B cells in healthy pregnancy.
Tue Sep 29 00:00:00 EDT 2020
Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis.
JCI insight
Henderson LA,Hoyt KJ,Lee PY,Rao DA,Jonsson AH,Nguyen JP,Rutherford K,Julé AM,Charbonnier LM,Case S,Chang MH,Cohen EM,Dedeoglu F,Fuhlbrigge RC,Halyabar O,Hazen MM,Janssen E,Kim S,Lo J,Lo MS,Meidan E,Son MBF,Sundel RP,Stoll ML,Nusbaum C,Lederer JA,Chatila TA,Nigrovic PA
48-4776 was used in Flow cytometry/Cell sorting to show how systemic juvenile idiopathic arthritis (sJIA) transitions from acute to chronic through the evolving Th17 polarization that begins in Tregs and progresses to T effector cells (Teffs).
Thu Mar 26 00:00:00 EDT 2020
50-Gy Stereotactic Body Radiation Therapy to the Dominant Intraprostatic Nodule: Results From a Phase 1a/b Trial.
International journal of radiation oncology, biology, physics
Herrera FG,Valerio M,Berthold D,Tawadros T,Meuwly JY,Vallet V,Baumgartner P,Thierry AC,De Bari B,Jichlinski P,Kandalaft L,Coukos G,Harari A,Bourhis J
48-4776-42 was used in Flow Cytometry to show stereotactic irradiation induced antigen-specific immune responses in a subset of patients.
Fri Feb 01 00:00:00 EST 2019
Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models.
Scientific reports
Wang Z,Sun K,Xiao Y,Feng B,Mikule K,Ma X,Feng N,Vellano CP,Federico L,Marszalek JR,Mills GB,Hanke J,Ramaswamy S,Wang J
48-4776 was used in Flow cytometry/Cell sorting to investigate the therapeutic potential of combining niraparib with anti-P-1 immune checkpoint inhibitors in preclinical tumour models.
Tue Feb 12 00:00:00 EST 2019
Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.
JCI insight
Lowe MM,Boothby I,Clancy S,Ahn RS,Liao W,Nguyen DN,Schumann K,Marson A,Mahuron KM,Kingsbury GA,Liu Z,Munoz Sandoval P,Rodriguez RS,Pauli ML,Taravati K,Arron ST,Neuhaus IM,Harris HW,Kim EA,Shin US,Krummel MF,Daud A,Scharschmidt TC,Rosenblum MD
48-4776 was used in Flow cytometry/Cell sorting to compare healthy skin Tregs with those in peripheral blood, inflamed psoriatic skin, and metastatic melanoma.
Thu Dec 19 00:00:00 EST 2019
Non-conventional Inhibitory CD4+Foxp3-PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity.
Cancer cell
Zappasodi R,Budhu S,Hellmann MD,Postow MA,Senbabaoglu Y,Manne S,Gasmi B,Liu C,Zhong H,Li Y,Huang AC,Hirschhorn-Cymerman D,Panageas KS,Wherry EJ,Merghoub T,Wolchok JD
48-4776-42 was used in Flow Cytometry to provide evidence that mouse and human circulating and intra-tumor 4PD1hi inhibit T cell functions in a PD-1/PD-L1 dependent fashion and resemble follicular helper T cell (TFH)-like cells.
Mon Jun 11 00:00:00 EDT 2018
An Autocrine TNFα-Tumor Necrosis Factor Receptor 2 Loop Promotes Epigenetic Effects Inducing Human Treg Stability In Vitro.
Frontiers in immunology
Urbano PCM,Koenen HJPM,Joosten I,He X
48-4776 was used in Flow Cytometry to explore the underlying mechanisms of rapamycin and tumour necrosis factor receptor 2 agonist-mediated regulatory T cell stability.
Tue May 28 00:00:00 EDT 2019
DNA Methyltransferase Inhibition Promotes Th1 Polarization in Human CD4+CD25high FOXP3+ Regulatory T Cells but Does Not Affect Their Suppressive Capacity.
Journal of immunology research
Landman S,Cruijsen M,Urbano PCM,Huls G,van Erp PEJ,van Rijssen E,Joosten I,Koenen HJPM
48-4776 was used in Flow cytometry/Cell sorting to examine the in vitro effect of derivative 5-aza-2'-deoxycytidine on the stability and function of FACS-sorted human naturally occurring CD4+CD25high FOXP3+ regulatory T cells.
Thu Oct 11 00:00:00 EDT 2018
RNA-seq and flow-cytometry of conventional, scalp, and palmoplantar psoriasis reveal shared and distinct molecular pathways.
Scientific reports
Ahn R,Yan D,Chang HW,Lee K,Bhattarai S,Huang ZM,Nakamura M,Singh R,Afifi L,Taravati K,Munoz-Sandoval P,Pauli M,Rosenblum MD,Liao W
Fri Jul 27 00:00:00 EDT 2018
Intradermal injection of low dose human regulatory T cells inhibits skin inflammation in a humanized mouse model.
Scientific reports
Landman S,de Oliveira VL,van Erp PEJ,Fasse E,Bauland SCG,Joosten I,Koenen HJPM
48-4776 was used in Flow cytometry/Cell sorting to evaluate if local delivery of low numbers of human regulatory T cells by intradermal injection prevents skin inflammation in the humanised mouse huPBL-SCID-huSkin allograft model.
Tue Jul 03 00:00:00 EDT 2018
PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients.
Cancer cell
Naing A,Infante JR,Papadopoulos KP,Chan IH,Shen C,Ratti NP,Rojo B,Autio KA,Wong DJ,Patel MR,Ott PA,Falchook GS,Pant S,Hung A,Pekarek KL,Wu V,Adamow M,McCauley S,Mumm JB,Wong P,Van Vlasselaer P,Leveque J,Tannir NM,Oft M
48-4776-42 was used in Flow cytometry/Cell sorting to report that pegilodecakin induces hallmarks of CD8+ T cell immunity in cancer patients, including elevation of interferon-γ and GranzymeB, expansion and activation of intratumoral CD8+ T cells, and proliferation and expansion of LAG-3+ PD-1+ CD8+ T cells.
Mon Nov 12 00:00:00 EST 2018
Phenotypic Complexity of the Human Regulatory T Cell Compartment Revealed by Mass Cytometry.
Journal of immunology (Baltimore, Md. : 1950)
Mason GM,Lowe K,Melchiotti R,Ellis R,de Rinaldis E,Peakman M,Heck S,Lombardi G,Tree TI
48-4776 was used in Flow cytometry/Cell sorting to examine the complexity of human Tregs using an extensive panel of surface markers associated with Treg function and phenotype.
Tue Sep 01 00:00:00 EDT 2015
Genetic analysis of an allergic rhinitis cohort reveals an intercellular epistasis between FAM134B and CD39.
BMC medical genetics
Melchiotti R,Puan KJ,Andiappan AK,Poh TY,Starke M,Zhuang L,Petsch K,Lai TS,Chew FT,Larbi A,Wang de Y,Poidinger M,Rotzschke O
48-4776 was used in Flow cytometry/Cell sorting to identify variants affecting CD39 expression on regulatory T cells, and evaluate their association with allergic rhinitis.
Fri Jun 27 00:00:00 EDT 2014
A functional variant in FCRL3 is associated with higher Fc receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity.
Arthritis and rheumatism
Bajpai UD,Swainson LA,Mold JE,Graf JD,Imboden JB,McCune JM
48-4776 was used in Flow cytometry/Cell sorting to indicate that Fc receptor-like 3 (FCRL3) expression, associated with the FCRL3-169C allele, may be a biomarker for rheumatoid arthritis disease activity.
Wed Aug 01 00:00:00 EDT 2012
Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of programmed cell death-1.
Journal of immunology (Baltimore, Md. : 1950)
Swainson LA,Mold JE,Bajpai UD,McCune JM
48-4776 was used in Flow cytometry/Cell sorting to suggest that FcRL3 expression is associated with T(reg) dysfunction that may, in turn, contribute to the loss of self-tolerance and the development of autoimmunity.
Thu Apr 01 00:00:00 EDT 2010
Protection against bronchiolitis obliterans syndrome is associated with allograft CCR7+ CD45RA- T regulatory cells.
PloS one
Gregson AL,Hoji A,Palchevskiy V,Hu S,Weigt SS,Liao E,Derhovanessian A,Saggar R,Song S,Elashoff R,Yang OO,Belperio JA
48-4776 was used in Flow cytometry/Cell sorting to hypothesize that frequencies of Treg in bronchoalveolar lavage fluid after lung transplantation would predict subsequent development of bronchiolitis obliterans syndrome.
Tue Jun 29 00:00:00 EDT 2010
Protection against bronchiolitis obliterans syndrome is associated with allograft CCR7+ CD45RA- T regulatory cells.
PloS one
Gregson AL,Hoji A,Palchevskiy V,Hu S,Weigt SS,Liao E,Derhovanessian A,Saggar R,Song S,Elashoff R,Yang OO,Belperio JA
48-4776 was used in Flow cytometry/Cell sorting to hypothesize that frequencies of Treg in bronchoalveolar lavage fluid after lung transplantation would predict subsequent development of bronchiolitis obliterans syndrome.
Tue Jun 29 00:00:00 EDT 2010
Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART.
Blood
Epple HJ,Loddenkemper C,Kunkel D,Tröger H,Maul J,Moos V,Berg E,Ullrich R,Schulzke JD,Stein H,Duchmann R,Zeitz M,Schneider T
Wed Nov 01 00:00:00 EST 2006
Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Lim HW,Hillsamer P,Banham AH,Kim CH
Sat Oct 01 00:00:00 EDT 2005