Product References
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy.
Nature communications
Xiao X,Shi J,He C,Bu X,Sun Y,Gao M,Xiang B,Xiong W,Dai P,Mao Q,Xing X,Yao Y,Yu H,Xu G,Li S,Ren Y,Chen B,Jiang C,Meng G,Lee YR,Wei W,Freeman GJ,Xie C,Zhang J
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Fri May 19 00:00:00 EDT 2023
Small-molecule PTPN2 Inhibitors Sensitize Resistant Melanoma to Anti-PD-1 Immunotherapy.
Cancer research communications
Zhu Z,Tang R,Huff S,Kummetha IR,Wang L,Li N,Rana TM
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2023
Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity.
The Journal of clinical investigation
Ren J,Li N,Pei S,Lian Y,Li L,Peng Y,Liu Q,Guo J,Wang X,Han Y,Zhang G,Wang H,Li Y,Jiang J,Li Q,Tan M,Peng J,Hu G,Xiao Y,Li X,Lin M,Qin J
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Fri Apr 15 00:00:00 EDT 2022
Wnt5A Signaling Blocks Progression of Experimental Visceral Leishmaniasis.
Frontiers in immunology
Maity S,Chakraborty A,Mahata SK,Roy S,Das AK,Sen M
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Tue Mar 22 00:00:00 EDT 2022
Intranasal Delivery of Recombinant S100A8 Protein Delays Lung Cancer Growth by Remodeling the Lung Immune Microenvironment.
Frontiers in immunology
Wong SW,McCarroll J,Hsu K,Geczy CL,Tedla N
46-8898-82 was used in Flow cytometry/Cell sorting to indicate that treatment with S100A8 may favourably modify the lung microenvironment to promote an effective immune response in lungs, thereby representing a new strategy that could complement current immunotherapies in lung cancer.
Mon Jun 06 00:00:00 EDT 2022
Intranasal Delivery of Recombinant S100A8 Protein Delays Lung Cancer Growth by Remodeling the Lung Immune Microenvironment.
Frontiers in immunology
Wong SW,McCarroll J,Hsu K,Geczy CL,Tedla N
46-8898-82 was used in Flow cytometry/Cell sorting to indicate that treatment with S100A8 may favourably modify the lung microenvironment to promote an effective immune response in lungs, thereby representing a new strategy that could complement current immunotherapies in lung cancer.
Mon Jun 06 00:00:00 EDT 2022
eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma.
Journal for immunotherapy of cancer
Chen X,Wang K,Jiang S,Sun H,Che X,Zhang M,He J,Wen Y,Liao M,Li X,Zhou X,Song J,Ren X,Yi W,Yang J,Chen X,Yin M,Cheng Y
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2022
RAD21 amplification epigenetically suppresses interferon signaling to promote immune evasion in ovarian cancer.
The Journal of clinical investigation
Deng P,Wang Z,Chen J,Liu S,Yao X,Liu S,Liu L,Yu Z,Huang Y,Xiong Z,Xiao R,Gao J,Liang W,Chen J,Liu H,Hong JH,Chan JY,Guan P,Chen J,Wang Y,Yin J,Li J,Zheng M,Zhang C,Zhou P,Kang T,Teh BT,Yu Q,Zuo Z,Jiang Q,Liu J,Xiong Y,Xia X,Tan J
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Tue Nov 15 00:00:00 EST 2022
PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells.
Nature communications
Li Q,Zhang L,You W,Xu J,Dai J,Hua D,Zhang R,Yao F,Zhou S,Huang W,Dai Y,Zhang Y,Baheti T,Qian X,Pu L,Xu J,Xia Y,Zhang C,Tang J,Wang X
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Mon Dec 12 00:00:00 EST 2022
Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy.
Cell reports
Wang W,Wu S,Cen Z,Zhang Y,Chen Y,Huang Y,Cillo AR,Prokopec JS,Quarato G,Vignali DAA,Stewart-Ornstein J,Li S,Lu B,Gong YN
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Tue Nov 01 00:00:00 EDT 2022
Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3.
Nature immunology
Grebinoski S,Zhang Q,Cillo AR,Manne S,Xiao H,Brunazzi EA,Tabib T,Cardello C,Lian CG,Murphy GF,Lafyatis R,Wherry EJ,Das J,Workman CJ,Vignali DAA
46-8898-82 was used in Flow cytometry/Cell sorting to show that intra-islet CD8+ T cells phenotypically, transcriptionally, epigenetically and metabolically possess features of canonically exhausted T cells, yet maintain important differences.
Wed Jun 01 00:00:00 EDT 2022
WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway.
The Journal of experimental medicine
Guo E,Xiao R,Wu Y,Lu F,Liu C,Yang B,Li X,Fu Y,Wang Z,Li Y,Huang Y,Li F,Wu X,You L,Qin T,Lu Y,Huang X,Ma D,Mills GB,Sun C,Chen G
46-8898-82 was used in Flow cytometry/Cell sorting to demonstrate that targeting WEE1 up-regulates immune signaling through the double-stranded RNA (dsRNA) viral defense pathway with subsequent responsiveness to immune checkpoint blockade even in cGAS/STING-deficient tumors, which is a typical phenotype across multiple cancer types.
Mon Jan 03 00:00:00 EST 2022
Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function.
Cell reports
Daneshmandi S,Cassel T,Lin P,Higashi RM,Wulf GM,Boussiotis VA,Fan TW,Seth P
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Tue Mar 09 00:00:00 EST 2021
Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy.
Cell reports
Dodagatta-Marri E,Ma HY,Liang B,Li J,Meyer DS,Chen SY,Sun KH,Ren X,Zivak B,Rosenblum MD,Headley MB,Pinzas L,Reed NI,Del Cid JS,Hann BC,Yang S,Giddabasappa A,Noorbehesht K,Yang B,Dal Porto J,Tsukui T,Niessen K,Atakilit A,Akhurst RJ,Sheppard D
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Tue Jul 06 00:00:00 EDT 2021
Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration.
Cell communication and signaling : CCS
Li J,Wang S,Wang N,Zheng Y,Yang B,Wang X,Zhang J,Pan B,Wang Z
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Mon Aug 30 00:00:00 EDT 2021
Extracellular Vesicles from Akkermansia muciniphila Elicit Antitumor Immunity Against Prostate Cancer via Modulation of CD8+ T Cells and Macrophages.
International journal of nanomedicine
Luo ZW,Xia K,Liu YW,Liu JH,Rao SS,Hu XK,Chen CY,Xu R,Wang ZX,Xie H
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Tue Jun 01 00:00:00 EDT 2021
Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection.
iScience
Steele L,Mannion AJ,Shaw G,Maclennan KA,Cook GP,Rudd CE,Taylor A
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Fri Jun 25 00:00:00 EDT 2021
Circadian Clock Disruption Suppresses PDL1+ Intraepithelial B Cells in Experimental Colitis and Colitis-Associated Colorectal Cancer.
Cellular and molecular gastroenterology and hepatology
Liu JL,Wang CY,Cheng TY,Rixiati Y,Ji C,Deng M,Yao S,Yuan LH,Zhao YY,Shen T,Li JM
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Mon Jan 24 00:00:00 EST 2022
Knockout of immunotherapy prognostic marker genes eliminates the effect of the anti-PD-1 treatment.
NPJ precision oncology
Yang N,Ji F,Cheng L,Lu J,Sun X,Lin X,Lan X
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Fri May 07 00:00:00 EDT 2021
Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors.
Journal of hematology & oncology
Li Y,Zhang Y,Cao G,Zheng X,Sun C,Wei H,Tian Z,Xiao W,Sun R,Sun H
46-8898-82 was used in Flow Cytometry to investigate the effect of PVRIG on tumor progression using patient paraffin-embedded colon adenocarcinoma sections, various murine tumor models (MC38 colon cancer, MCA205 fibrosarcoma and LLC lung cancer), and human NK cell- or PBMC-reconstituted xenograft models (SW620 colon cancer).
Sat Jun 26 00:00:00 EDT 2021
Assessment of the WAP-Myc mouse mammary tumor model for spontaneous metastasis.
Scientific reports
Utz B,Turpin R,Lampe J,Pouwels J,Klefström J
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Fri Oct 30 00:00:00 EDT 2020
Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Restructures the Immune Contexture to Improve Checkpoint Blockade Efficacy.
Biomedicines
Ebelt ND,Zuniga E,Marzagalli M,Zamloot V,Blazar BR,Salgia R,Manuel ER
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Wed Dec 16 00:00:00 EST 2020
Memory CD73+IgM+ B cells protect against Plasmodium yoelii infection and express Granzyme B.
PloS one
Parra M,Weitner M,Yang A,Akue A,Liu X,Schmidt T,Allman WR,Akkoyunlu M,Derrick SC
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Tue Oct 27 00:00:00 EDT 2020
Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy.
Nature communications
Shi L,Wang J,Ding N,Zhang Y,Zhu Y,Dong S,Wang X,Peng C,Zhou C,Zhou L,Li X,Shi H,Wu W,Long X,Wu C,Liao W
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Thu Nov 28 00:00:00 EST 2019
MAIT cells contribute to protection against lethal influenza infection in vivo.
Nature communications
van Wilgenburg B,Loh L,Chen Z,Pediongco TJ,Wang H,Shi M,Zhao Z,Koutsakos M,Nüssing S,Sant S,Wang Z,D'Souza C,Jia X,Almeida CF,Kostenko L,Eckle SBG,Meehan BS,Kallies A,Godfrey DI,Reading PC,Corbett AJ,McCluskey J,Klenerman P,Kedzierska K,Hinks TSC
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Fri Nov 09 00:00:00 EST 2018
Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function.
Nature communications
Wang F,Meng M,Mo B,Yang Y,Ji Y,Huang P,Lai W,Pan X,You T,Luo H,Guan X,Deng Y,Yuan S,Chu J,Namaka M,Hughes T,Ye L,Yu J,Li X,Deng Y
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Mon Nov 19 00:00:00 EST 2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.
Nature communications
Kim DH,Park HJ,Lim S,Koo JH,Lee HG,Choi JO,Oh JH,Ha SJ,Kang MJ,Lee CM,Lee CG,Elias JA,Choi JM
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Mon Feb 05 00:00:00 EST 2018
Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation.
Science translational medicine
Allen E,Jabouille A,Rivera LB,Lodewijckx I,Missiaen R,Steri V,Feyen K,Tawney J,Hanahan D,Michael IP,Bergers G
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Wed Apr 12 00:00:00 EDT 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Mon Jun 05 00:00:00 EDT 2017
CD8+ T Cells Effect Glomerular Injury in Experimental Anti-Myeloperoxidase GN.
Journal of the American Society of Nephrology : JASN
Chang J,Eggenhuizen P,O'Sullivan KM,Alikhan MA,Holdsworth SR,Ooi JD,Kitching AR
46-8898 was used in Flow cytometry/Cell sorting to study the pathological role of CD8+ T cells in ANCA-associated vasculitis.
Sun Jan 01 00:00:00 EST 2017
1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8+ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model.
Frontiers in immunology
Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis.
Nature communications
Krzywinska E,Kantari-Mimoun C,Kerdiles Y,Sobecki M,Isagawa T,Gotthardt D,Castells M,Haubold J,Millien C,Viel T,Tavitian B,Takeda N,Fandrey J,Vivier E,Sexl V,Stockmann C
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Fri Nov 17 00:00:00 EST 2017
The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas.
Oncoimmunology
Sonner JK,Deumelandt K,Ott M,Thomé CM,Rauschenbach KJ,Schulz S,Munteanu B,Mohapatra S,Adam I,Hofer AC,Feuerer M,Opitz CA,Hopf C,Wick W,Platten M
Tue Jan 12 00:00:00 EST 2021
Long-term intravital imaging of the multicolor-coded tumor microenvironment during combination immunotherapy.
eLife
Qi S,Li H,Lu L,Qi Z,Liu L,Chen L,Shen G,Fu L,Luo Q,Zhang Z
46-8898 was used in Flow cytometry/Cell sorting to establish an optimal strategy of metronomic combined-immunotherapy to enhance anti-tumor efficacy.
Fri Nov 18 00:00:00 EST 2016
Caribbean and La Réunion Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology.
Journal of virology
Teo TH,Her Z,Tan JJ,Lum FM,Lee WW,Chan YH,Ong RY,Kam YW,Leparc-Goffart I,Gallian P,Rénia L,de Lamballerie X,Ng LF
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2015
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.
Nature communications
Chen L,Gibbons DL,Goswami S,Cortez MA,Ahn YH,Byers LA,Zhang X,Yi X,Dwyer D,Lin W,Diao L,Wang J,Roybal J,Patel M,Ungewiss C,Peng D,Antonia S,Mediavilla-Varela M,Robertson G,Suraokar M,Welsh JW,Erez B,Wistuba II,Chen L,Peng D,Wang S,Ullrich SE,Heymach JV,Kurie JM,Qin FX
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Tue Oct 28 00:00:00 EDT 2014
Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock.
PloS one
Hou H,Liu W,Wu S,Lu Y,Peng J,Zhu Y,Lu Y,Wang F,Sun Z
Published figure using Granzyme B monoclonal antibody (Product # 46-8898-82) in Flow Cytometry
Mon Jul 06 00:00:00 EDT 2015