Product References
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy.
Nature communications
Xiao X,Shi J,He C,Bu X,Sun Y,Gao M,Xiang B,Xiong W,Dai P,Mao Q,Xing X,Yao Y,Yu H,Xu G,Li S,Ren Y,Chen B,Jiang C,Meng G,Lee YR,Wei W,Freeman GJ,Xie C,Zhang J
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Fri May 19 00:00:00 EDT 2023
Small-molecule PTPN2 Inhibitors Sensitize Resistant Melanoma to Anti-PD-1 Immunotherapy.
Cancer research communications
Zhu Z,Tang R,Huff S,Kummetha IR,Wang L,Li N,Rana TM
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2023
Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity.
The Journal of clinical investigation
Ren J,Li N,Pei S,Lian Y,Li L,Peng Y,Liu Q,Guo J,Wang X,Han Y,Zhang G,Wang H,Li Y,Jiang J,Li Q,Tan M,Peng J,Hu G,Xiao Y,Li X,Lin M,Qin J
50-8898-82 was used in Flow Cytometry to establish a tumor-suppressive function of WHSC1 that relays IFN-γ signaling to promote antigen presentation in CRC cells, and provide a rationale for boosting WHSC1 activity in immunotherapy.
Fri Apr 15 00:00:00 EDT 2022
Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity.
The Journal of clinical investigation
Ren J,Li N,Pei S,Lian Y,Li L,Peng Y,Liu Q,Guo J,Wang X,Han Y,Zhang G,Wang H,Li Y,Jiang J,Li Q,Tan M,Peng J,Hu G,Xiao Y,Li X,Lin M,Qin J
50-8898-82 was used in Flow Cytometry to establish a tumor-suppressive function of WHSC1 that relays IFN-γ signaling to promote antigen presentation in CRC cells, and provide a rationale for boosting WHSC1 activity in immunotherapy.
Fri Apr 15 00:00:00 EDT 2022
Wnt5A Signaling Blocks Progression of Experimental Visceral Leishmaniasis.
Frontiers in immunology
Maity S,Chakraborty A,Mahata SK,Roy S,Das AK,Sen M
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Tue Mar 22 00:00:00 EDT 2022
Intranasal Delivery of Recombinant S100A8 Protein Delays Lung Cancer Growth by Remodeling the Lung Immune Microenvironment.
Frontiers in immunology
Wong SW,McCarroll J,Hsu K,Geczy CL,Tedla N
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Mon Jun 06 00:00:00 EDT 2022
eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma.
Journal for immunotherapy of cancer
Chen X,Wang K,Jiang S,Sun H,Che X,Zhang M,He J,Wen Y,Liao M,Li X,Zhou X,Song J,Ren X,Yi W,Yang J,Chen X,Yin M,Cheng Y
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Immunohistochemistry
Tue Mar 01 00:00:00 EST 2022
eEF2K promotes PD-L1 stabilization through inactivating GSK3β in melanoma.
Journal for immunotherapy of cancer
Chen X,Wang K,Jiang S,Sun H,Che X,Zhang M,He J,Wen Y,Liao M,Li X,Zhou X,Song J,Ren X,Yi W,Yang J,Chen X,Yin M,Cheng Y
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Immunohistochemistry
Tue Mar 01 00:00:00 EST 2022
RAD21 amplification epigenetically suppresses interferon signaling to promote immune evasion in ovarian cancer.
The Journal of clinical investigation
Deng P,Wang Z,Chen J,Liu S,Yao X,Liu S,Liu L,Yu Z,Huang Y,Xiong Z,Xiao R,Gao J,Liang W,Chen J,Liu H,Hong JH,Chan JY,Guan P,Chen J,Wang Y,Yin J,Li J,Zheng M,Zhang C,Zhou P,Kang T,Teh BT,Yu Q,Zuo Z,Jiang Q,Liu J,Xiong Y,Xia X,Tan J
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Tue Nov 15 00:00:00 EST 2022
PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells.
Nature communications
Li Q,Zhang L,You W,Xu J,Dai J,Hua D,Zhang R,Yao F,Zhou S,Huang W,Dai Y,Zhang Y,Baheti T,Qian X,Pu L,Xu J,Xia Y,Zhang C,Tang J,Wang X
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Mon Dec 12 00:00:00 EST 2022
Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy.
Cell reports
Wang W,Wu S,Cen Z,Zhang Y,Chen Y,Huang Y,Cillo AR,Prokopec JS,Quarato G,Vignali DAA,Stewart-Ornstein J,Li S,Lu B,Gong YN
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Tue Nov 01 00:00:00 EDT 2022
Camptothesome elicits immunogenic cell death to boost colorectal cancer immune checkpoint blockade.
Journal of controlled release : official journal of the Controlled Release Society
Wang Z,Li W,Park J,Gonzalez KM,Scott AJ,Lu J
50-8898-82 was used in Flow cytometry/Cell sorting to decipher that Camptothesome was taken up by colorectal cancer (CRC) cells through primarily the clathrin-mediated endocytotic pathway and displayed the potential of eliciting robust immunogenic cancer cell death (ICD) via upregulating calreticulin, high mobility group box 1 protein (HMGB-1), and adenosine triphosphate (ATP), three hallmarks involved in the induction of ICD.
Thu Sep 01 00:00:00 EDT 2022
Non-synergy of PD-1 blockade with T-cell therapy in solid tumors.
Journal for immunotherapy of cancer
Davies JS,Karimipour F,Zhang L,Nagarsheth N,Norberg S,Serna C,Strauss J,Chiou S,Gulley JL,Hinrichs CS
50-8898-82 was used in Flow cytometry/Cell sorting to support the concept that PD-1 blockade acts primarily through endogenous rather than transferred T cells to mediate a non-synergistic antitumor effect in solid tumor cell therapy.
Fri Jul 01 00:00:00 EDT 2022
Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function.
Cell reports
Daneshmandi S,Cassel T,Lin P,Higashi RM,Wulf GM,Boussiotis VA,Fan TW,Seth P
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Tue Mar 09 00:00:00 EST 2021
Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy.
Cell reports
Dodagatta-Marri E,Ma HY,Liang B,Li J,Meyer DS,Chen SY,Sun KH,Ren X,Zivak B,Rosenblum MD,Headley MB,Pinzas L,Reed NI,Del Cid JS,Hann BC,Yang S,Giddabasappa A,Noorbehesht K,Yang B,Dal Porto J,Tsukui T,Niessen K,Atakilit A,Akhurst RJ,Sheppard D
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Tue Jul 06 00:00:00 EDT 2021
Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration.
Cell communication and signaling : CCS
Li J,Wang S,Wang N,Zheng Y,Yang B,Wang X,Zhang J,Pan B,Wang Z
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Mon Aug 30 00:00:00 EDT 2021
Extracellular Vesicles from Akkermansia muciniphila Elicit Antitumor Immunity Against Prostate Cancer via Modulation of CD8+ T Cells and Macrophages.
International journal of nanomedicine
Luo ZW,Xia K,Liu YW,Liu JH,Rao SS,Hu XK,Chen CY,Xu R,Wang ZX,Xie H
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Tue Jun 01 00:00:00 EDT 2021
Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection.
iScience
Steele L,Mannion AJ,Shaw G,Maclennan KA,Cook GP,Rudd CE,Taylor A
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Fri Jun 25 00:00:00 EDT 2021
Circadian Clock Disruption Suppresses PDL1+ Intraepithelial B Cells in Experimental Colitis and Colitis-Associated Colorectal Cancer.
Cellular and molecular gastroenterology and hepatology
Liu JL,Wang CY,Cheng TY,Rixiati Y,Ji C,Deng M,Yao S,Yuan LH,Zhao YY,Shen T,Li JM
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Mon Jan 24 00:00:00 EST 2022
Knockout of immunotherapy prognostic marker genes eliminates the effect of the anti-PD-1 treatment.
NPJ precision oncology
Yang N,Ji F,Cheng L,Lu J,Sun X,Lin X,Lan X
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Fri May 07 00:00:00 EDT 2021
Identification of HLA-A2-Restricted Mutant Epitopes from Neoantigens of Esophageal Squamous Cell Carcinoma.
Vaccines
Wang Z,Ran L,Chen C,Shi R,Dong Y,Li Y,Zhou X,Qi Y,Zhu P,Gao Y,Wu Y
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Protein Assays and Analysis
Fri Oct 01 00:00:00 EDT 2021
Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function.
Cell metabolism
Kurniawan H,Franchina DG,Guerra L,Bonetti L,-Baguet LS,Grusdat M,Schlicker L,Hunewald O,Dostert C,Merz MP,Binsfeld C,Duncan GS,Farinelle S,Nonnenmacher Y,Haight J,Das Gupta D,Ewen A,Taskesen R,Halder R,Chen Y,Jäger C,Ollert M,Wilmes P,Vasiliou V,Harris IS,Knobbe-Thomsen CB,Turner JD,Mak TW,Lohoff M,Meiser J,Hiller K,Brenner D
50-8898 was used in Flow cytometry/Cell sorting to reveal an unexpected role for GSH in restricting serine availability to preserve Treg functionality.
Tue May 05 00:00:00 EDT 2020
Assessment of the WAP-Myc mouse mammary tumor model for spontaneous metastasis.
Scientific reports
Utz B,Turpin R,Lampe J,Pouwels J,Klefström J
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Fri Oct 30 00:00:00 EDT 2020
Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Restructures the Immune Contexture to Improve Checkpoint Blockade Efficacy.
Biomedicines
Ebelt ND,Zuniga E,Marzagalli M,Zamloot V,Blazar BR,Salgia R,Manuel ER
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Wed Dec 16 00:00:00 EST 2020
Memory CD73+IgM+ B cells protect against Plasmodium yoelii infection and express Granzyme B.
PloS one
Parra M,Weitner M,Yang A,Akue A,Liu X,Schmidt T,Allman WR,Akkoyunlu M,Derrick SC
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Tue Oct 27 00:00:00 EDT 2020
Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy.
Nature communications
Shi L,Wang J,Ding N,Zhang Y,Zhu Y,Dong S,Wang X,Peng C,Zhou C,Zhou L,Li X,Shi H,Wu W,Long X,Wu C,Liao W
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Thu Nov 28 00:00:00 EST 2019
Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1.
Cell reports
Gawish R,Bulat T,Biaggio M,Lassnig C,Bago-Horvath Z,Macho-Maschler S,Poelzl A,Simonović N,Prchal-Murphy M,Rom R,Amenitsch L,Ferrarese L,Kornhoff J,Lederer T,Svinka J,Eferl R,Bosmann M,Kalinke U,Stoiber D,Sexl V,Krmpotić A,Jonjić S,Müller M,Strobl B
50-8898 was used in Flow cytometry/Cell sorting to provide genetic evidence that signaling through STAT1 in myeloid cells is required to restrict MCMV at early time points post-infection and to induce compensatory hematopoiesis in the spleen.
Tue Feb 26 00:00:00 EST 2019
Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells.
Immunity
Li J,Lee Y,Li Y,Jiang Y,Lu H,Zang W,Zhao X,Liu L,Chen Y,Tan H,Yang Z,Zhang MQ,Mak TW,Ni L,Dong C
50-8898 was used in Flow cytometry/Cell sorting to demonstrate that increased B7S1 expression in myeloid cells from human hepatocellular carcinoma is correlated with CD8+ T cell dysfunction.
Tue Apr 17 00:00:00 EDT 2018
Breast Cancer Chemo-immunotherapy through Liposomal Delivery of an Immunogenic Cell Death Stimulus Plus Interference in the IDO-1 Pathway.
ACS nano
Lu J,Liu X,Liao YP,Wang X,Ahmed A,Jiang W,Ji Y,Meng H,Nel AE
50-8898 was used in Flow cytometry/Cell sorting to develop a chemo-immunotherapy approach to reduce the high mortality of metastatic breast cancer, utilising a liposomal carrier to trigger immunogenic cell death.
Tue Nov 27 00:00:00 EST 2018
MAIT cells contribute to protection against lethal influenza infection in vivo.
Nature communications
van Wilgenburg B,Loh L,Chen Z,Pediongco TJ,Wang H,Shi M,Zhao Z,Koutsakos M,Nüssing S,Sant S,Wang Z,D'Souza C,Jia X,Almeida CF,Kostenko L,Eckle SBG,Meehan BS,Kallies A,Godfrey DI,Reading PC,Corbett AJ,McCluskey J,Klenerman P,Kedzierska K,Hinks TSC
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Fri Nov 09 00:00:00 EST 2018
Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function.
Nature communications
Wang F,Meng M,Mo B,Yang Y,Ji Y,Huang P,Lai W,Pan X,You T,Luo H,Guan X,Deng Y,Yuan S,Chu J,Namaka M,Hughes T,Ye L,Yu J,Li X,Deng Y
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Mon Nov 19 00:00:00 EST 2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.
Nature communications
Kim DH,Park HJ,Lim S,Koo JH,Lee HG,Choi JO,Oh JH,Ha SJ,Kang MJ,Lee CM,Lee CG,Elias JA,Choi JM
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Mon Feb 05 00:00:00 EST 2018
Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.
The Journal of clinical investigation
Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF
50-8898 was used in Flow cytometry/Cell sorting to show that miR-27 has a role in regulating Treg immune cells and that correct control of miR-27 expression is important to safeguard immunological tolerance..
Wed Feb 01 00:00:00 EST 2017
Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation.
Science translational medicine
Allen E,Jabouille A,Rivera LB,Lodewijckx I,Missiaen R,Steri V,Feyen K,Tawney J,Hanahan D,Michael IP,Bergers G
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Wed Apr 12 00:00:00 EDT 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Mon Jun 05 00:00:00 EDT 2017
1810011o10 Rik Inhibits the Antitumor Effect of Intratumoral CD8+ T Cells through Suppression of Notch2 Pathway in a Murine Hepatocellular Carcinoma Model.
Frontiers in immunology
Dai K,Huang L,Huang YB,Chen ZB,Yang LH,Jiang YA
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis.
Nature communications
Krzywinska E,Kantari-Mimoun C,Kerdiles Y,Sobecki M,Isagawa T,Gotthardt D,Castells M,Haubold J,Millien C,Viel T,Tavitian B,Takeda N,Fandrey J,Vivier E,Sexl V,Stockmann C
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Fri Nov 17 00:00:00 EST 2017
IL-12 and IL-4 activate a CD39-dependent intrinsic peripheral tolerance mechanism in CD8(+) T cells.
European journal of immunology
Noble A,Mehta H,Lovell A,Papaioannou E,Fairbanks L
50-8898 was used in Flow cytometry/Cell sorting to study the upregulation of CD39 on CD8(+) T cells and identify a novel pathway of peripheral tolerance.
Wed Jun 01 00:00:00 EDT 2016
Protein Translation Activity: A New Measure of Host Immune Cell Activation.
Journal of immunology (Baltimore, Md. : 1950)
Seedhom MO,Hickman HD,Wei J,David A,Yewdell JW
50-8898 was used in Flow cytometry/Cell sorting to describe the in vivo ribopuromycylation method.
Mon Aug 15 00:00:00 EDT 2016
The stress kinase GCN2 does not mediate suppression of antitumor T cell responses by tryptophan catabolism in experimental melanomas.
Oncoimmunology
Sonner JK,Deumelandt K,Ott M,Thomé CM,Rauschenbach KJ,Schulz S,Munteanu B,Mohapatra S,Adam I,Hofer AC,Feuerer M,Opitz CA,Hopf C,Wick W,Platten M
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Caribbean and La Réunion Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology.
Journal of virology
Teo TH,Her Z,Tan JJ,Lum FM,Lee WW,Chan YH,Ong RY,Kam YW,Leparc-Goffart I,Gallian P,Rénia L,de Lamballerie X,Ng LF
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2015
Caribbean and La Réunion Chikungunya Virus Isolates Differ in Their Capacity To Induce Proinflammatory Th1 and NK Cell Responses and Acute Joint Pathology.
Journal of virology
Teo TH,Her Z,Tan JJ,Lum FM,Lee WW,Chan YH,Ong RY,Kam YW,Leparc-Goffart I,Gallian P,Rénia L,de Lamballerie X,Ng LF
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2015
Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints.
Nature communications
Mikucki ME,Fisher DT,Matsuzaki J,Skitzki JJ,Gaulin NB,Muhitch JB,Ku AW,Frelinger JG,Odunsi K,Gajewski TF,Luster AD,Evans SS
50-8898 was used in Flow cytometry/Cell sorting to investigate the hierarchy of chemokine receptor requirements during T-cell trafficking to murine and human melanoma.
Thu Jun 25 00:00:00 EDT 2015
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.
Nature communications
Chen L,Gibbons DL,Goswami S,Cortez MA,Ahn YH,Byers LA,Zhang X,Yi X,Dwyer D,Lin W,Diao L,Wang J,Roybal J,Patel M,Ungewiss C,Peng D,Antonia S,Mediavilla-Varela M,Robertson G,Suraokar M,Welsh JW,Erez B,Wistuba II,Chen L,Peng D,Wang S,Ullrich SE,Heymach JV,Kurie JM,Qin FX
Published figure using Granzyme B monoclonal antibody (Product # 50-8898-82) in Flow Cytometry
Tue Oct 28 00:00:00 EDT 2014
Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock.
PloS one
Hou H,Liu W,Wu S,Lu Y,Peng J,Zhu Y,Lu Y,Wang F,Sun Z
50-8898 was used in Flow cytometry/Cell sorting to study the role of Tim-3 in the regulation of natural killer cells following LPS-induced shock.
Mon Jul 06 00:00:00 EDT 2015