Product References
HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease.
JCI insight
Little AJ,Chen PM,Vesely MD,Khan RN,Fiedler J,Garritano J,Maisha FI,McNiff JM,Craft J
12-5825-82 was used in Flow cytometry/Cell sorting to demonstrate in human CLE tissue that the T cell-rich inflammatory infiltrate exhibited increased amounts of HIF-1 and a cytotoxic signature.
Tue Aug 22 00:00:00 EDT 2023
The Potential of Dendritic-Cell-Based Vaccines to Modulate Type 3 Innate Lymphoid Cell Populations.
International journal of molecular sciences
Chan L,Mehrani Y,Minott JA,Bridle BW,Karimi K
12-5825-82 was used in Flow cytometry/Cell sorting to explore the communications between type 3 ILCs (ILC3s) and DCs using a murine model of DC-based vaccination.
Thu Jan 26 00:00:00 EST 2023
Loss of SLC26A3 Results in Colonic Mucosal Immune Dysregulation via Epithelial-Immune Cell Crosstalk.
Cellular and molecular gastroenterology and hepatology
Jayawardena D,Priyamvada S,Kageyama T,White Z,Kumar A,Griggs TF,Majumder A,Akram R,Anbazhagan AN,Sano T,Dudeja PK
12-5825-82 was used in Flow cytometry/Cell sorting to establish that T2 immune dysregulation in response to loss of DRA was due to altered epithelial-immune cell crosstalk via IL-33.
Tue Mar 21 00:00:00 EDT 2023
Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs.
Frontiers in immunology
Bowakim-Anta N,Acolty V,Azouz A,Yagita H,Leo O,Goriely S,Oldenhove G,Moser M
12-5825-82 was used in Flow cytometry/Cell sorting to conclude that CD27 may regulate the development of Th1 immunity in peripheral tissues as well as the subsequent switch of the effector response into long-term memory.
Thu Apr 06 00:00:00 EDT 2023
Hobit and Blimp-1 instruct the differentiation of iNKT cells into resident-phenotype lymphocytes after lineage commitment.
European journal of immunology
Kragten NA,Taggenbrock RL,Parga Vidal L,van Lier RA,Stark R,van Gisbergen KP
12-5825-82 was used in Flow cytometry/Cell sorting to conclude that memory differentiation and the establishment of residency occur after lineage commitment through a Hobit and Blimp-1-driven transcriptional program.
Tue Mar 01 00:00:00 EST 2022
Transcriptional profiling of human Vδ1 T cells reveals a pathogen-driven adaptive differentiation program.
Cell reports
McMurray JL,von Borstel A,Taher TE,Syrimi E,Taylor GS,Sharif M,Rossjohn J,Remmerswaal EBM,Bemelman FJ,Vieira Braga FA,Chen X,Teichmann SA,Mohammed F,Berry AA,Lyke KE,Williamson KC,Stubbington MJT,Davey MS,Willcox CR,Willcox BE
12-5825-82 was used in Flow Cytometry to show that adult Vδ1+ T cells segregate into TCF7+LEF1+Granzyme Bneg (Tnaive) or T-bet+Eomes+BLIMP-1+Granzyme B+.
Tue May 24 00:00:00 EDT 2022
Candida tropicalis Infection Modulates the Gut Microbiome and Confers Enhanced Susceptibility to Colitis in Mice.
Cellular and molecular gastroenterology and hepatology
Di Martino L,De Salvo C,Buela KA,Hager C,Ghannoum M,Osme A,Buttò L,Bamias G,Pizarro TT,Cominelli F
12-5825-82 was used in Flow Cytometry to determine the effects and mechanisms of action of Candida tropicalis on intestinal inflammation and injury in mouse models.
Mon Apr 04 00:00:00 EDT 2022
ILC precursors differentiate into metabolically distinct ILC1-like cells during Mycobacterium tuberculosis infection.
Cell reports
Corral D,Charton A,Krauss MZ,Blanquart E,Levillain F,Lefrançais E,Sneperger T,Vahlas Z,Girard JP,Eberl G,Poquet Y,Guéry JC,Argüello RJ,Belkaid Y,Mayer-Barber KD,Hepworth MR,Neyrolles O,Hudrisier D
12-5825-82 was used in Flow cytometry/Cell sorting to reveal how tissue-resident ILCs adapt to type 1 inflammation toward a pathogen-tailored immune response.
Tue Apr 19 00:00:00 EDT 2022
MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function.
Immunity
Sugiura A,Andrejeva G,Voss K,Heintzman DR,Xu X,Madden MZ,Ye X,Beier KL,Chowdhury NU,Wolf MM,Young AC,Greenwood DL,Sewell AE,Shahi SK,Freedman SN,Cameron AM,Foerch P,Bourne T,Garcia-Canaveras JC,Karijolich J,Newcomb DC,Mangalam AK,Rabinowitz JD,Rathmell JC
12-5825-82 was used in Flow cytometry/Cell sorting to show that MTHFD2 is a metabolic checkpoint to integrate purine metabolism with pathogenic effector cell signaling and is a potential therapeutic target within 1C metabolism pathways.
Tue Jan 11 00:00:00 EST 2022
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).
European journal of immunology
Cossarizza A,Chang HD,Radbruch A,Abrignani S,Addo R,Akdis M,Andrä I,Andreata F,Annunziato F,Arranz E,Bacher P,Bari S,Barnaba V,Barros-Martins J,Baumjohann D,Beccaria CG,Bernardo D,Boardman DA,Borger J,Böttcher C,Brockmann L,Burns M,Busch DH,Cameron G,Cammarata I,Cassotta A,Chang Y,Chirdo FG,Christakou E,Čičin-Šain L,Cook L,Corbett AJ,Cornelis R,Cosmi L,Davey MS,De Biasi S,De Simone G,Del Zotto G,Delacher M,Di Rosa F,Di Santo J,Diefenbach A,Dong J,Dörner T,Dress RJ,Dutertre CA,Eckle SBG,Eede P,Evrard M,Falk CS,Feuerer M,Fillatreau S,Fiz-Lopez A,Follo M,Foulds GA,Fröbel J,Gagliani N,Galletti G,Gangaev A,Garbi N,Garrote JA,Geginat J,Gherardin NA,Gibellini L,Ginhoux F,Godfrey DI,Gruarin P,Haftmann C,Hansmann L,Harpur CM,Hayday AC,Heine G,Hernández DC,Herrmann M,Hoelsken O,Huang Q,Huber S,Huber JE,Huehn J,Hundemer M,Hwang WYK,Iannacone M,Ivison SM,Jäck HM,Jani PK,Keller B,Kessler N,Ketelaars S,Knop L,Knopf J,Koay HF,Kobow K,Kriegsmann K,Kristyanto H,Krueger A,Kuehne JF,Kunze-Schumacher H,Kvistborg P,Kwok I,Latorre D,Lenz D,Levings MK,Lino AC,Liotta F,Long HM,Lugli E,MacDonald KN,Maggi L,Maini MK,Mair F,Manta C,Manz RA,Mashreghi MF,Mazzoni A,McCluskey J,Mei HE,Melchers F,Melzer S,Mielenz D,Monin L,Moretta L,Multhoff G,Muñoz LE,Muñoz-Ruiz M,Muscate F,Natalini A,Neumann K,Ng LG,Niedobitek A,Niemz J,Almeida LN,Notarbartolo S,Ostendorf L,Pallett LJ,Patel AA,Percin GI,Peruzzi G,Pinti M,Pockley AG,Pracht K,Prinz I,Pujol-Autonell I,Pulvirenti N,Quatrini L,Quinn KM,Radbruch H,Rhys H,Rodrigo MB,Romagnani C,Saggau C,Sakaguchi S,Sallusto F,Sanderink L,Sandrock I,Schauer C,Scheffold A,Scherer HU,Schiemann M,Schildberg FA,Schober K,Schoen J,Schuh W,Schüler T,Schulz AR,Schulz S,Schulze J,Simonetti S,Singh J,Sitnik KM,Stark R,Starossom S,Stehle C,Szelinski F,Tan L,Tarnok A,Tornack J,Tree TIM,van Beek JJP,van de Veen W,van Gisbergen K,Vasco C,Verheyden NA,von Borstel A,Ward-Hartstonge KA,Warnatz K,Waskow C,Wiedemann A,Wilharm A,Wing J,Wirz O,Wittner J,Yang JHM,Yang J
12-5825-82 was used in Flow cytometry/Cell sorting to provide the key aspects to consider when performing flow cytometry experiments.
Wed Dec 01 00:00:00 EST 2021
Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack.
Cell reports. Medicine
Bonilla WV,Kirchhammer N,Marx AF,Kallert SM,Krzyzaniak MA,Lu M,Darbre S,Schmidt S,Raguz J,Berka U,Vincenti I,Pauzuolis M,Kerber R,Hoepner S,Günther S,Magnus C,Merkler D,Orlinger KK,Zippelius A,Pinschewer DD
12-5825-82 was used in Flow Cytometry to establish an arenavirus-based immunotherapy regimen that allows reshuffling of immunodominance hierarchies and breaking self-directed tolerance for efficient tumor control.
Tue Mar 16 00:00:00 EDT 2021
IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques.
Nature communications
Harper J,Huot N,Micci L,Tharp G,King C,Rascle P,Shenvi N,Wang H,Galardi C,Upadhyay AA,Villinger F,Lifson J,Silvestri G,Easley K,Jacquelin B,Bosinger S,Müller-Trutwin M,Paiardini M
12-5825 was used in Flow cytometry/Cell sorting to generate terminally differentiated blood natural killer cells (NKG2a/clowCD16+) with potent human leukocyte antigen-E-restricted activity in response to SIV envelope peptides.
Mon May 17 00:00:00 EDT 2021
Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis.
Journal of neuroinflammation
Chen YH,Eskandarpour M,Zhang X,Galatowicz G,Greenwood J,Lightman S,Calder V
12-5825-82 was used in Flow Cytometry to show that the α4β1 integrin inhibitor may exert a modulatory effect in EAU progression by selectively blocking Th17 cell migration across the blood-retinal barrier without affecting systemic CD4+ T cell subsets.
Thu Feb 18 00:00:00 EST 2021
The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.
Cell
Kitamoto S,Nagao-Kitamoto H,Jiao Y,Gillilland MG,Hayashi A,Imai J,Sugihara K,Miyoshi M,Brazil JC,Kuffa P,Hill BD,Rizvi SM,Wen F,Bishu S,Inohara N,Eaton KA,Nusrat A,Lei YL,Giannobile WV,Kamada N
12-5825-82 was used in Flow Cytometry to conclude that oral inflammation, such as periodontitis, exacerbates gut inflammation by supplying the gut with both colitogenic pathobionts and pathogenic T cells.
Thu Jul 23 00:00:00 EDT 2020
Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.
Immunity
DiToro D,Harbour SN,Bando JK,Benavides G,Witte S,Laufer VA,Moseley C,Singer JR,Frey B,Turner H,Bruning J,Darley-Usmar V,Gao M,Conover C,Hatton RD,Frank S,Colonna M,Weaver CT
12-5825 was used in Flow cytometry/Cell sorting to show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system.
Tue Apr 14 00:00:00 EDT 2020
SRC-3 Functions as a Coactivator of T-bet by Regulating the Maturation and Antitumor Activity of Natural Killer Cells.
Cancer immunology research
Hu M,Lu Y,Qi Y,Zhang Z,Wang S,Xu Y,Chen F,Tang Y,Chen S,Chen M,Du C,Shen M,Wang F,Su Y,Deng Y,Wang J
12-5825-82 was used in Flow Cytometry to study the role of SRC-3 as a coactivator of T-bet in natural killer-cell biology and indicate that targeting SRC-3 may be a promising strategy to increase the tumor surveillance function of natural killer cells.
Tue Sep 01 00:00:00 EDT 2020
Differential Activation of Unconventional T Cells, Including iNKT Cells, in Alcohol-Related Liver Disease.
Alcoholism, clinical and experimental research
Marrero I,Maricic I,Morgan TR,Stolz AA,Schnabl B,Liu ZX,Tsukamoto H,Kumar V
12-5825-82 was used in Flow Cytometry to investigate the role of innate-like unconventional T cells in alcohol-related liver disease.
Fri May 01 00:00:00 EDT 2020
NK and T Cell Differentiation at the Maternal-Fetal Interface in Sows During Late Gestation.
Frontiers in immunology
Stas MR,Koch M,Stadler M,Sawyer S,Sassu EL,Mair KH,Saalmüller A,Gerner W,Ladinig A
12-5825-82 was used in Flow Cytometry to investigate the immune cell phenotype on late gestation in pigs.
Tue Jun 22 00:00:00 EDT 2021
The Identity of Human Tissue-Emigrant CD8+ T Cells.
Cell
Buggert M,Vella LA,Nguyen S,Wu VH,Chen Z,Sekine T,Perez-Potti A,Maldini CR,Manne S,Darko S,Ransier A,Kuri-Cervantes L,Japp AS,Brody IB,Ivarsson MA,Gorin JB,Rivera-Ballesteros O,Hertwig L,Antel JP,Johnson ME,Okoye A,Picker L,Vahedi G,Sparrelid E,Llewellyn-Lacey S,Gostick E,Sandberg JK,Björkström N,Bar-Or A,Dori Y,Naji A,Canaday DH,Laufer TM,Wells AD,Price DA,Frank I,Douek DC,Wherry EJ,Itkin MG,Betts MR
12-5825-82 was used in Flow cytometry/Cell sorting to employ an integrated approach to characterize tissue-emigrant lineages in thoracic duct lymph (TDL).
Wed Dec 23 00:00:00 EST 2020
CD19-CAR-T Cells Bearing a KIR/PD-1-Based Inhibitory CAR Eradicate CD19+HLA-C1- Malignant B Cells While Sparing CD19+HLA-C1+ Healthy B Cells.
Cancers
Tao L,Farooq MA,Gao Y,Zhang L,Niu C,Ajmal I,Zhou Y,He C,Zhao G,Yao J,Liu M,Jiang W
12-5825 was used in Flow cytometry/Cell sorting to engineer a novel KIR/PD-1-based inhibitory CAR (iKP CAR) by fusing the extracellular domain of killer cell immunoglobulin-like receptors (KIR) 2DL2 (KIR2DL2) and the intracellular domain of PD-1.
Sun Sep 13 00:00:00 EDT 2020
Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.
Cell
Jin C,Lagoudas GK,Zhao C,Bullman S,Bhutkar A,Hu B,Ameh S,Sandel D,Liang XS,Mazzilli S,Whary MT,Meyerson M,Germain R,Blainey PC,Fox JG,Jacks T
12-5825 was used in Flow cytometry/Cell sorting to link local microbiota-immune crosstalk to lung tumor development and thereby define key cellular and molecular mediators that may serve as effective targets in lung cancer intervention.
Thu Feb 21 00:00:00 EST 2019
Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells.
Immunity
Pokrovskii M,Hall JA,Ochayon DE,Yi R,Chaimowitz NS,Seelamneni H,Carriero N,Watters A,Waggoner SN,Littman DR,Bonneau R,Miraldi ER
12-5825 was used in Flow cytometry/Cell sorting to study regulatory interactions between transcription factors and genes within intestinal type 1, 2, and 3 innate lymphoid cells subsets.
Tue Jul 16 00:00:00 EDT 2019
Subsets of ILC3-ILC1-like cells generate a diversity spectrum of innate lymphoid cells in human mucosal tissues.
Nature immunology
Cella M,Gamini R,Sécca C,Collins PL,Zhao S,Peng V,Robinette ML,Schettini J,Zaitsev K,Gordon W,Bando JK,Yomogida K,Cortez V,Fronick C,Fulton R,Lin LL,Gilfillan S,Flavell RA,Shan L,Artyomov MN,Bowman M,Oltz EM,Jelinsky SA,Colonna M
12-5825 was used in Flow cytometry/Cell sorting to demonstrate that innate lymphoid cells (ILCs) undergo conversion from ILC3s into ILC1-like cells in human tissues in vivo, requiring tissue factors and Aiolos in the process.
Thu Aug 01 00:00:00 EDT 2019
Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation.
Science signaling
Jun JE,Kulhanek KR,Chen H,Chakraborty A,Roose JP
12-5825 was used in Flow cytometry/Cell sorting to investigate how both classical and alternative p38 pathways contribute to T cell activation and therefore the immune balance.
Tue Jul 23 00:00:00 EDT 2019
Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity.
Cell reports
DeVorkin L,Pavey N,Carleton G,Comber A,Ho C,Lim J,McNamara E,Huang H,Kim P,Zacharias LG,Mizushima N,Saitoh T,Akira S,Beckham W,Lorzadeh A,Moksa M,Cao Q,Murthy A,Hirst M,DeBerardinis RJ,Lum JJ
12-5825 was used in Flow cytometry/Cell sorting to demonstrate a cell-autonomous role for autophagy in the regulation of CD8+ T-cell-mediated control of tumors.
Tue Apr 09 00:00:00 EDT 2019
Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation.
Cell reports
Ciecko AE,Foda B,Barr JY,Ramanathan S,Atkinson MA,Serreze DV,Geurts AM,Lieberman SM,Chen YG
12-5825-82 was used in Flow Cytometry to reveal that IL-27 contributes to autoimmunity in NOD mice through multiple mechanisms and provides substantial evidence to support its pathogenic role in human T1D.
Tue Dec 03 00:00:00 EST 2019
Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer.
Cell reports
Choi H,Deng J,Li S,Silk T,Dong L,Brea EJ,Houghton S,Redmond D,Zhong H,Boiarsky J,Akbay EA,Smith PD,Merghoub T,Wong KK,Wolchok JD
12-5825 was used in Flow cytometry/Cell sorting to set the foundation and show the importance of a combinatorial therapeutic strategy using pulsatile targeted therapy together with immunotherapy to optimally enhance tumor delay and promote long-term anti-tumor immunity.
Tue Apr 16 00:00:00 EDT 2019
A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade.
Nature medicine
Thommen DS,Koelzer VH,Herzig P,Roller A,Trefny M,Dimeloe S,Kiialainen A,Hanhart J,Schill C,Hess C,Savic Prince S,Wiese M,Lardinois D,Ho PC,Klein C,Karanikas V,Mertz KD,Schumacher TN,Zippelius A
12-5825 was used in Flow cytometry/Cell sorting to compare transcriptional, metabolic and functional signatures of intratumoral CD8+ T lymphocyte populations with high, intermediate and no PD-1 expression from non-small-cell lung cancer patients.
Sun Jul 01 00:00:00 EDT 2018
B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen.
Immunity
Hong S,Zhang Z,Liu H,Tian M,Zhu X,Zhang Z,Wang W,Zhou X,Zhang F,Ge Q,Zhu B,Tang H,Hua Z,Hou B
12-5825-82 was used in Flow Cytometry to demonstrate that antigen-specific B cells were the dominant antigen-presenting cells that initiated naive CD4+ T cell activation. Using RNA phage Qβ-derived VLP (Qβ-VLP) as a model antigen.
Tue Oct 16 00:00:00 EDT 2018
Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses.
Nature immunology
Ugolini M,Gerhard J,Burkert S,Jensen KJ,Georg P,Ebner F,Volkers SM,Thada S,Dietert K,Bauer L,Schäfer A,Helbig ET,Opitz B,Kurth F,Sur S,Dittrich N,Gaddam S,Conrad ML,Benn CS,Blohm U,Gruber AD,Hutloff A,Hartmann S,Boekschoten MV,Müller M,Jungersen G,Schumann RR,Suttorp N,Sander LE
12-5825-82 was used in Flow Cytometry to identify TLR8 as an important driver of TFH cell differentiation and a promising target for TFH cell-skewing vaccine adjuvants.
Sun Apr 01 00:00:00 EDT 2018
Inducible Costimulator Expressing T Cells Promote Parasitic Growth During Blood Stage Plasmodium berghei ANKA Infection.
Frontiers in immunology
Jogdand GM,Sengupta S,Bhattacharya G,Singh SK,Barik PK,Devadas S
12-5825 was used in Flow cytometry/Cell sorting to study the role of inducible costimulator in lethal blood-stage of Plasmodium berghei ANKA infection.
Thu Jul 11 00:00:00 EDT 2019
TRPM2 Exacerbates Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis by Increasing Production of CXCL2 Chemokines.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tsutsui M,Hirase R,Miyamura S,Nagayasu K,Nakagawa T,Mori Y,Shirakawa H,Kaneko S
12-5825-82 was used in Flow Cytometry to reveal an important role of TRPM2 in the pathogenesis of EAE and shed light on its potential as a therapeutic target.
Wed Sep 26 00:00:00 EDT 2018
Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming.
Cell reports
Simula L,Pacella I,Colamatteo A,Procaccini C,Cancila V,Bordi M,Tregnago C,Corrado M,Pigazzi M,Barnaba V,Tripodo C,Matarese G,Piconese S,Campello S
12-5825 was used in Flow cytometry/Cell sorting to describe the crucial role of the mitochondrial protein Drp1 in T cell development and regulation of lymphocyte immune-surveillance.
Tue Dec 11 00:00:00 EST 2018
Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function.
Nature communications
Wang F,Meng M,Mo B,Yang Y,Ji Y,Huang P,Lai W,Pan X,You T,Luo H,Guan X,Deng Y,Yuan S,Chu J,Namaka M,Hughes T,Ye L,Yu J,Li X,Deng Y
12-5825 was used in Flow cytometry/Cell sorting to elucidate the crosstalk between Raptor (mTORC1) and Rictor (mTORC2) to variegate cytokine signalling in controlling natural killer cell maturation and effector function.
Mon Nov 19 00:00:00 EST 2018
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.
Nature communications
Govindarajan S,Gaublomme D,Van der Cruyssen R,Verheugen E,Van Gassen S,Saeys Y,Tavernier S,Iwawaki T,Bloch Y,Savvides SN,Lambrecht BN,Janssens S,Elewaut D,Drennan MB
12-5825 was used in Flow cytometry/Cell sorting to examine the role of the IRE1α-dependent signalling cascade in coupling constitutive cytokine mRNA expression to the rapid induction of cytokine secretion and effector functions in activated iNKT cells.
Mon Dec 17 00:00:00 EST 2018
Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.
Immunity
Fu B,Zhou Y,Ni X,Tong X,Xu X,Dong Z,Sun R,Tian Z,Wei H
12-5825-82 was used in Flow Cytometry to reveal properties of Natural Killer (NK) cells in promoting fetal growth.
Tue Dec 19 00:00:00 EST 2017
Enhancement of IFNγ Production by Distinct Commensals Ameliorates Salmonella-Induced Disease.
Cell host & microbe
Thiemann S,Smit N,Roy U,Lesker TR,Gálvez EJC,Helmecke J,Basic M,Bleich A,Goodman AL,Kalinke U,Flavell RA,Erhardt M,Strowig T
12-5825 was used in Flow cytometry/Cell sorting to study the modulation of the strength of Salmonella Typhimurium infection by the enteric commensal microbiota composition.
Wed Jun 14 00:00:00 EDT 2017
The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway.
Science translational medicine
Wen Z,Shen Y,Berry G,Shahram F,Li Y,Watanabe R,Liao YJ,Goronzy JJ,Weyand CM
12-5825 was used in Flow cytometry/Cell sorting to study the VEGF-Jagged1-Notch pathway and the effects of T cells in pathogenic large vessel vasculitis.
Wed Jul 19 00:00:00 EDT 2017
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4.
Nature communications
Campos Carrascosa L,Klein M,Kitagawa Y,Lückel C,Marini F,König A,Guralnik A,Raifer H,Hagner-Benes S,Rädler D,Böck A,Kang C,Lohoff M,Garn H,Schaub B,Berberich-Siebelt F,Sakaguchi S,Bopp T,Huber M
12-5825 was used in Flow cytometry/Cell sorting to study the opposing effects of interferon regulatory factor1 and IRF4 on T helper 9 cell differentiation.
Fri May 12 00:00:00 EDT 2017
Forced expression of IL-7R promotes CD8 T cell cytotoxicity to self antigen.
PloS one
Peng Y
12-5825 was used in Flow Cytometry to demonstrate that forced expression of IL-7R improved the functionality of tolerized CD8 T cells and acted in synergy with PDL-1 deficiency to further promote CD8 T cell cytotoxicity to self antigens.
Tue Jan 16 00:00:00 EST 2018
Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response.
Frontiers in cellular and infection microbiology
Ahmed N,French T,Rausch S,Kühl A,Hemminger K,Dunay IR,Steinfelder S,Hartmann S
12-5825 was used in Flow cytometry/Cell sorting to conclude a previous T. gondii infection limits a helminth-specific Th2 immune response while promoting a shift toward a Th1-type immune response.
Mon Apr 02 00:00:00 EDT 2018
Temporal Dynamics of CD8+ T Cell Effector Responses during Primary HIV Infection.
PLoS pathogens
Demers KR,Makedonas G,Buggert M,Eller MA,Ratcliffe SJ,Goonetilleke N,Li CK,Eller LA,Rono K,Maganga L,Nitayaphan S,Kibuuka H,Routy JP,Slifka MK,Haynes BF,McMichael AJ,Bernard NF,Robb ML,Betts MR
12-5825 was used in Flow cytometry/Cell sorting to assess the CD8+ T cell functional evolution from primary to chronic HIV infection, demonstrating that progressive transcriptional dysregulation leads to the reduced CD8+ T cell perforin expression and loss of cytolytic potential characteristic of chronic HIV infection.
Mon Aug 01 00:00:00 EDT 2016
IL-12 and IL-4 activate a CD39-dependent intrinsic peripheral tolerance mechanism in CD8(+) T cells.
European journal of immunology
Noble A,Mehta H,Lovell A,Papaioannou E,Fairbanks L
12-5825 was used in Flow cytometry/Cell sorting to study the upregulation of CD39 on CD8(+) T cells and identify a novel pathway of peripheral tolerance.
Wed Jun 01 00:00:00 EDT 2016
A Role for Regulatory T Cells in a Murine Model of Epicutaneous Toluene Diisocyanate Sensitization.
Toxicological sciences : an official journal of the Society of Toxicology
Long CM,Marshall NB,Lukomska E,Kashon ML,Meade BJ,Shane H,Anderson SE
12-5825 was used in Flow cytometry/Cell sorting to delineate the immunologic mechanisms of chemical-induced allergic disease.
Fri Jul 01 00:00:00 EDT 2016
Susceptibility to Ticks and Lyme Disease Spirochetes Is Not Affected in Mice Coinfected with Nematodes.
Infection and immunity
Maaz D,Rausch S,Richter D,Krücken J,Kühl AA,Demeler J,Blümke J,Matuschka FR,von Samson-Himmelstjerna G,Hartmann S
12-5825 was used in Flow cytometry/Cell sorting to analyse the immunological impact of the nematode/tick coinfection, showing that susceptibility to ticks and Lyme disease is not affected by coinfection.
Sun May 01 00:00:00 EDT 2016
Characterization and Quantification of Innate Lymphoid Cell Subsets in Human Lung.
PloS one
De Grove KC,Provoost S,Verhamme FM,Bracke KR,Joos GF,Maes T,Brusselle GG
12-5825 was used in Flow cytometry/Cell sorting to study innate lymphoid cells in the human lung in healthy patients and those with chronic pulmonary disease.
Fri Jul 08 00:00:00 EDT 2016
Simultaneous, Single-Cell Measurement of Messenger RNA, Cell Surface Proteins, and Intracellular Proteins.
Current protocols in cytometry
Soh KT,Tario JD,Colligan S,Maguire O,Pan D,Minderman H,Wallace PK
12-5825 was used in Flow cytometry/Cell sorting to develop a protocol for the simultaneous, single-cell measurement of mRNA, cell surface proteins, and intracellular proteins.
Wed Jan 06 00:00:00 EST 2016
Monoclonal regulatory T cells provide insights into T cell suppression.
Scientific reports
Gubser C,Schmaler M,Rossi SW,Palmer E
12-5825 was used in Flow cytometry/Cell sorting to investigate how Tregs function at a cellular and molecular level using monoclonal Tregs.
Mon May 23 00:00:00 EDT 2016
IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia.
Cell & bioscience
Xu A,Bhanumathy KK,Wu J,Ye Z,Freywald A,Leary SC,Li R,Xiang J
12-5825 was used in Flow cytometry/Cell sorting to investigate the mechanism for adoptively transferred effector T-cell survival and memory formation.
Mon May 09 00:00:00 EDT 2016
CD70 and IFN-1 selectively induce eomesodermin or T-bet and synergize to promote CD8+ T-cell responses.
European journal of immunology
Dong H,Franklin NA,Ritchea SB,Yagita H,Glennie MJ,Bullock TN
12-5825 was used in Flow cytometry/Cell sorting to identify complex interactions between signal 3 and costimulatory pathways, and identify opportunities to influence the differentiation of CD8(+) T-cell responses.
Tue Dec 01 00:00:00 EST 2015
The immunosuppressive enzyme IL4I1 promotes FoxP3(+) regulatory T lymphocyte differentiation.
European journal of immunology
Cousin C,Aubatin A,Le Gouvello S,Apetoh L,Castellano F,Molinier-Frenkel V
12-5825 was used in Flow cytometry/Cell sorting to study the effect of IL4I1 on naive CD4+ T cell differentiation.
Mon Jun 01 00:00:00 EDT 2015
Regulatory Dendritic Cells Restrain NK Cell IFN-γ Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors.
Journal of immunology (Baltimore, Md. : 1950)
Spallanzani RG,Torres NI,Avila DE,Ziblat A,Iraolagoitia XL,Rossi LE,Domaica CI,Fuertes MB,Rabinovich GA,Zwirner NW
12-5825 was used in Flow cytometry/Cell sorting to investigate the functional outcome of the interaction between regDC and NK cells and the associated underlying mechanisms.
Tue Sep 01 00:00:00 EDT 2015
Skewed T-helper (Th)1/2- and Th17/T regulatory‑cell balances in patients with renal cell carcinoma.
Molecular medicine reports
Li L,Yang C,Zhao Z,Xu B,Zheng M,Zhang C,Min Z,Guo J,Rong R
12-5825 was used in Flow cytometry/Cell sorting to demonstrate that the balance of Th1 and Th2 cells is skewed towards the Th2 profile in the peripheral blood of patients with RCC.
Sun Feb 01 00:00:00 EST 2015
Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells.
PLoS neglected tropical diseases
Katawa G,Layland LE,Debrah AY,von Horn C,Batsa L,Kwarteng A,Arriens S,W Taylor D,Specht S,Hoerauf A,Adjobimey T
12-5825 was used in Flow cytometry/Cell sorting to provide initial evidence that elevated frequencies of Th17 and Th2 cells form part of the immune network instigating the development of severe onchocerciasis.
Thu Jan 01 00:00:00 EST 2015
Iron prevents the development of experimental cerebral malaria by attenuating CXCR3-mediated T cell chemotaxis.
PloS one
Van Den Ham KM,Shio MT,Rainone A,Fournier S,Krawczyk CM,Olivier M
12-5825 was used in Flow cytometry/Cell sorting to determine that the incidence of ECM was markedly reduced in mice treated with iron dextran.
Thu Jan 21 00:00:00 EST 2016
A phase I dose-escalation clinical trial of a peptide-based human papillomavirus therapeutic vaccine with Candida skin test reagent as a novel vaccine adjuvant for treating women with biopsy-proven cervical intraepithelial neoplasia 2/3.
Oncoimmunology
Greenfield WW,Stratton SL,Myrick RS,Vaughn R,Donnalley LM,Coleman HN,Mercado M,Moerman-Herzog AM,Spencer HJ,Andrews-Collins NR,Hitt WC,Low GM,Manning NA,McKelvey SS,Smith D,Smith MV,Phillips AM,Quick CM,Jeffus SK,Hutchins LF,Nakagawa M
12-5825 was used in Flow cytometry/Cell sorting to demonstrate the safety of a human papillomavirus therapeutic vaccine, PepCan.
Thu Oct 01 00:00:00 EDT 2015
Induced expression of FcγRIIIa (CD16a) on CD4+ T cells triggers generation of IFN-γhigh subset.
The Journal of biological chemistry
Chauhan AK,Chen C,Moore TL,DiPaolo RJ
12-5825 was used in Flow cytometry/Cell sorting to describe for the first time a role for FcγRIIIa in CD4+ T-cell differentiation.
Fri Feb 20 00:00:00 EST 2015
Induced expression of FcγRIIIa (CD16a) on CD4+ T cells triggers generation of IFN-γhigh subset.
The Journal of biological chemistry
Chauhan AK,Chen C,Moore TL,DiPaolo RJ
12-5825 was used in Flow cytometry/Cell sorting to describe for the first time a role for FcγRIIIa in CD4+ T-cell differentiation.
Fri Feb 20 00:00:00 EST 2015
Human CD4+ T Helper Cell Responses after Tick-Borne Encephalitis Vaccination and Infection.
PloS one
Aberle JH,Schwaiger J,Aberle SW,Stiasny K,Scheinost O,Kundi M,Chmelik V,Heinz FX
12-5825 was used in Flow cytometry/Cell sorting to show that tick-borne encephalitis virus-specific CD4+ T cell responses are polyfunctional, but differ in cytokine patterns between vaccination and infection.
Tue May 31 00:00:00 EDT 2016
The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals.
Nature immunology
Salmond RJ,Brownlie RJ,Morrison VL,Zamoyska R
12-5825 was used in Flow cytometry/Cell sorting to study how loss-of-function PTPN22 alleles can lead to the population expansion of effector and/or memory T cells and a predisposition to human autoimmunity.
Mon Sep 01 00:00:00 EDT 2014
Adaptive immune contexture at the tumour site and downmodulation of circulating myeloid-derived suppressor cells in the response of solitary fibrous tumour patients to anti-angiogenic therapy.
British journal of cancer
Tazzari M,Negri T,Rini F,Vergani B,Huber V,Villa A,Dagrada P,Colombo C,Fiore M,Gronchi A,Stacchiotti S,Casali PG,Pilotti S,Rivoltini L,Castelli C
12-5825 was used in Flow cytometry/Cell sorting to study the in situ and systemic immune status of advanced solitary fibrous tumour patients and the effects of sunitinib malate in association with clinical efficacy.
Tue Sep 23 00:00:00 EDT 2014
T-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infection.
PLoS pathogens
Buggert M,Tauriainen J,Yamamoto T,Frederiksen J,Ivarsson MA,Michaëlsson J,Lund O,Hejdeman B,Jansson M,Sönnerborg A,Koup RA,Betts MR,Karlsson AC
12-5825 was used in Flow cytometry/Cell sorting to investigate the inability of HIV-specific CD8(+) T cells to control the viral replication post-ART cessation.
Tue Jul 01 00:00:00 EDT 2014
Phenotypic Identification of Spinal Cord-Infiltrating CD4+ T Lymphocytes in a Murine Model of Neuropathic Pain.
Journal of pain & relief
Draleau K,Maddula S,Slaiby A,Nutile-McMenemy N,De Leo J,Cao L
12-5825 was used in Flow cytometry/Cell sorting to investigate the phenotype of spinal cord-infiltrating CD4+ T lymphocytes involved in the maintenance of neuropathic pain in a murine model.
Sun Jun 01 00:00:00 EDT 2014
Induction of broad cytotoxic T cells by protective DNA vaccination against Marburg and Ebola.
Molecular therapy : the journal of the American Society of Gene Therapy
Shedlock DJ,Aviles J,Talbott KT,Wong G,Wu SJ,Villarreal DO,Myles DJ,Croyle MA,Yan J,Kobinger GP,Weiner DB
12-5825 was used in Flow cytometry/Cell sorting to investigate the efficacy of cytotoxic T cell induction by a novel polyvalent-filovirus DNA vaccine against Marburg and Ebola.
Mon Jul 01 00:00:00 EDT 2013
Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation.
PLoS biology
Peine M,Rausch S,Helmstetter C,Fröhlich A,Hegazy AN,Kühl AA,Grevelding CG,Höfer T,Hartmann S,Löhning M
12-5825 was used in Flow cytometry/Cell sorting to characterise Th1/Th2 hybrid cells and assess their role in inflammation.
Thu Mar 06 00:00:00 EST 2014
Association of a NOD2 gene polymorphism and T-helper 17 cells with presumed ocular toxoplasmosis.
The Journal of infectious diseases
Dutra MS,Béla SR,Peixoto-Rangel AL,Fakiola M,Cruz AG,Gazzinelli A,Quites HF,Bahia-Oliveira LM,Peixe RG,Campos WR,Higino-Rocha AC,Miller NE,Blackwell JM,Antonelli LR,Gazzinelli RT
12-5825 was used in Flow cytometry/Cell sorting to suggest that NOD2 influences the production of IL-17A by CD4 T lymphocytes and might contribute to the development of ocular toxoplasmosis.
Tue Jan 01 00:00:00 EST 2013
Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during respiratory syncytial virus infection in mice.
Journal of virology
Durant LR,Makris S,Voorburg CM,Loebbermann J,Johansson C,Openshaw PJ
12-5825 was used in Flow cytometry/Cell sorting to provide evidence that dysregulation of normal immune responses to viral infection may contribute to severe respiratory viral disease.
Tue Oct 01 00:00:00 EDT 2013
Differential localization of T-bet and Eomes in CD8 T cell memory populations.
Journal of immunology (Baltimore, Md. : 1950)
McLane LM,Banerjee PP,Cosma GL,Makedonas G,Wherry EJ,Orange JS,Betts MR
12-5825 was used in Flow cytometry/Cell sorting to further understand the role of the T-box transcription factors T-bet and Eomes in human CD8 T cell differentiation.
Mon Apr 01 00:00:00 EDT 2013
Effects of PARP-1 deficiency on Th1 and Th2 cell differentiation.
TheScientificWorldJournal
Sambucci M,Laudisi F,Novelli F,Bennici E,Rosado MM,Pioli C
12-5825 was used in Flow cytometry/Cell sorting to demonstrate that PARP-1 plays a role in Th2 cell differentiation and may be a target for Th2-dependent immune-mediated disease modulation.
Mon Jun 16 00:00:00 EDT 2014
Nitric oxide inhibits the accumulation of CD4+CD44hiTbet+CD69lo T cells in mycobacterial infection.
European journal of immunology
Pearl JE,Torrado E,Tighe M,Fountain JJ,Solache A,Strutt T,Swain S,Appelberg R,Cooper AM
12-5825 was used in Flow cytometry/Cell sorting to support the hypothesis that effector T cells in mycobacterial granulomata are not a uniform effector population but exist in distinct subsets with differential susceptibility to the regulatory effects of nitric oxide.
Sat Dec 01 00:00:00 EST 2012
IL-17 and IFN-γ expression in lymphocytes from patients with active tuberculosis correlates with the severity of the disease.
Journal of leukocyte biology
Jurado JO,Pasquinelli V,Alvarez IB,Peña D,Rovetta AI,Tateosian NL,Romeo HE,Musella RM,Palmero D,Chuluyán HE,García VE
12-5825 was used in Flow cytometry/Cell sorting to investigate the induction and regulation of IFN-γ and IL-17 during active human Mycobacterium tuberculosis infection.
Fri Jun 01 00:00:00 EDT 2012
CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential.
Journal of immunology (Baltimore, Md. : 1950)
Radulovic K,Manta C,Rossini V,Holzmann K,Kestler HA,Wegenka UM,Nakayama T,Niess JH
12-5825 was used in Flow cytometry/Cell sorting to demonstrate that CD69 knockout can modulate mucosal CD4 T cells and increase colitis levels in a mouse transfer model of the disease.
Wed Feb 15 00:00:00 EST 2012
Differential effects of IL-12 on Tregs and non-Treg T cells: roles of IFN-γ, IL-2 and IL-2R.
PloS one
Zhao J,Zhao J,Perlman S
12-5825 was used in Flow cytometry/Cell sorting to investigate whether loss of immunosuppression occurs when IFN-γ is expressed by Tregs, showing differential effects of IL-12 on Tregs and non-Treg T cells.
Thu Feb 21 00:00:00 EST 2013
Matrix metalloproteinase-2 conditions human dendritic cells to prime inflammatory T(H)2 cells via an IL-12- and OX40L-dependent pathway.
Cancer cell
Godefroy E,Manches O,Dréno B,Hochman T,Rolnitzky L,Labarrière N,Guilloux Y,Goldberg J,Jotereau F,Bhardwaj N
12-5825 was used in Flow cytometry/Cell sorting to reveal that MMP2-conditioned DCs prime Th2 responses against several melanoma-associated antigens, highlighting the potential of MMP2 as a target antigen in melanoma.
Tue Mar 08 00:00:00 EST 2011
Increased HIV-specific CD8+ T-cell cytotoxic potential in HIV elite controllers is associated with T-bet expression.
Blood
Hersperger AR,Martin JN,Shin LY,Sheth PM,Kovacs CM,Cosma GL,Makedonas G,Pereyra F,Walker BD,Kaul R,Deeks SG,Betts MR
12-5825 was used in Flow cytometry/Cell sorting to show that T-bet may play an important role in driving effector function, and its modulation may lead to enhanced effector activity against HIV.
Thu Apr 07 00:00:00 EDT 2011
A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity.
Journal of immunology (Baltimore, Md. : 1950)
Fujimoto K,Karuppuchamy T,Takemura N,Shimohigoshi M,Machida T,Haseda Y,Aoshi T,Ishii KJ,Akira S,Uematsu S
12-5825 was used in Flow cytometry/Cell sorting to characterise CD8α(+) dendritic cells in the lamina propria of the small intestine.
Wed Jun 01 00:00:00 EDT 2011
Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950)
LaCasse CJ,Janikashvili N,Larmonier CB,Alizadeh D,Hanke N,Kartchner J,Situ E,Centuori S,Har-Noy M,Bonnotte B,Katsanis E,Larmonier N
12-5825 was used in Flow cytometry/Cell sorting to investigate the regulation of murine dendritic cell cytotoxic functions by T lymphocytes.
Thu Dec 15 00:00:00 EST 2011
CXCR3 deficiency exacerbates liver disease and abrogates tolerance in a mouse model of immune-mediated hepatitis.
Journal of immunology (Baltimore, Md. : 1950)
Erhardt A,Wegscheid C,Claass B,Carambia A,Herkel J,Mittrücker HW,Panzer U,Tiegs G
12-5825 was used in Flow cytometry/Cell sorting to discovered that CXCR3(+)T-bet(+)IL-10(+) Tregs are generated in the liver, disseminate into the organism and migrate into the liver, limiting immune-mediated liver damage.
Sun May 01 00:00:00 EDT 2011
Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950)
McClymont SA,Putnam AL,Lee MR,Esensten JH,Liu W,Hulme MA,Hoffmüller U,Baron U,Olek S,Bluestone JA,Brusko TM
12-5825 was used in Flow cytometry/Cell sorting to assess the differences in phenotype plasticity of human regulatory T cells in healthy patients, and patients with type 1 diabetes.
Fri Apr 01 00:00:00 EDT 2011
RNA sequencing reveals two major classes of gene expression levels in metazoan cells.
Molecular systems biology
Hebenstreit D,Fang M,Gu M,Charoensawan V,van Oudenaarden A,Teichmann SA
12-5825 was used in Flow cytometry/Cell sorting to investigate the global distribution of gene expression levels, suggesting that genes can be separated into two distinct groups: one group comprised of lowly expressed and putatively non-functional mRNAs, and the other of highly expressed mRNAs with active chromatin marks at their promoters.
Tue Jun 07 00:00:00 EDT 2011
Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells.
Nature immunology
Pepper M,Linehan JL,Pagán AJ,Zell T,Dileepan T,Cleary PP,Jenkins MK
12-5825 was used in Flow cytometry/Cell sorting to suggest that TH1 cells induced by intravenous infection are more efficient at entering the memory pool than TH-17 cells induced by intranasal infection.
Fri Jan 01 00:00:00 EST 2010
Human cytomegalovirus elicits fetal gammadelta T cell responses in utero.
The Journal of experimental medicine
Vermijlen D,Brouwer M,Donner C,Liesnard C,Tackoen M,Van Rysselberge M,Twité N,Goldman M,Marchant A,Willems F
12-5825 was used in Flow cytometry/Cell sorting to indicate that functional fetal gammadelta T cell responses can be generated during development in utero and suggest that this T cell subset could participate in antiviral defense in early life.
Mon Apr 12 00:00:00 EDT 2010
FOXP3+ regulatory T cells and T helper 1, T helper 2, and T helper 17 cells in human early pregnancy decidua.
Biology of reproduction
Mjösberg J,Berg G,Jenmalm MC,Ernerudh J
12-5825 was used in Flow cytometry/Cell sorting to study the chemokine receptor expression profiles in human pregnancy decidua to monitor levels of TH1, TH2, TH17 and Treg cells.
Thu Apr 01 00:00:00 EDT 2010
