Product References
Perinatal murine cytomegalovirus infection reshapes the transcriptional profile and functionality of NK cells.
Nature communications
Rožmanić C,Lisnić B,Pribanić Matešić M,Mihalić A,Hiršl L,Park E,Lesac Brizić A,Indenbirken D,Viduka I,Šantić M,Adler B,Yokoyama WM,Krmpotić A,Juranić Lisnić V,Jonjić S,Brizić I
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Thu Oct 12 00:00:00 EDT 2023
The Potential of Dendritic-Cell-Based Vaccines to Modulate Type 3 Innate Lymphoid Cell Populations.
International journal of molecular sciences
Chan L,Mehrani Y,Minott JA,Bridle BW,Karimi K
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Thu Jan 26 00:00:00 EST 2023
GM-CSF-activated human dendritic cells promote type 1 T follicular helper cell polarization in a CD40-dependent manner.
Journal of cell science
Korniotis S,Saichi M,Trichot C,Hoffmann C,Amblard E,Viguier A,Grondin S,Noel F,Mattoo H,Soumelis V
45-5825-82 was used in Flow cytometry/Cell sorting to report that human blood CD1c+ dendritic cells activated by GM-CSF (also known as CSF2) drive the differentiation of naive CD4+ T cells into Tfh1 cells.
Tue Nov 01 00:00:00 EDT 2022
GM-CSF-activated human dendritic cells promote type 1 T follicular helper cell polarization in a CD40-dependent manner.
Journal of cell science
Korniotis S,Saichi M,Trichot C,Hoffmann C,Amblard E,Viguier A,Grondin S,Noel F,Mattoo H,Soumelis V
45-5825-82 was used in Flow cytometry/Cell sorting to report that human blood CD1c+ dendritic cells activated by GM-CSF (also known as CSF2) drive the differentiation of naive CD4+ T cells into Tfh1 cells.
Tue Nov 01 00:00:00 EDT 2022
Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis.
Cell reports
Viladomiu M,Khounlotham M,Dogan B,Lima SF,Elsaadi A,Cardakli E,Castellanos JG,Ng C,Herzog J,Schoenborn AA,Ellermann M,Liu B,Zhang S,Gulati AS,Sartor RB,Simpson KW,Lipkin SM,Longman RS
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Tue Nov 15 00:00:00 EST 2022
Intracellular Acetyl CoA Potentiates the Therapeutic Efficacy of Antitumor CD8+ T Cells.
Cancer research
Chowdhury S,Kar A,Bhowmik D,Gautam A,Basak D,Sarkar I,Ghosh P,Sarkar D,Deka A,Chakraborty P,Mukhopadhyay A,Mehrotra S,Basak S,Paul S,Chatterjee S
45-5825-82 was used in Flow cytometry/Cell sorting to delineate the metabolic configuration of CD8+ T cells required for stable effector function in tumors and present an affordable approach to promote the efficacy of CD8+ T cells for adoptive T-cell therapy.
Mon Jul 18 00:00:00 EDT 2022
NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function.
Cell reports
Kumar A,Yarosz EL,Andren A,Zhang L,Lyssiotis CA,Chang CH
45-5825-82 was used in Flow cytometry/Cell sorting to highlight a distinct metabolic requirement of NKT cells compared with CD4 T cells, which may have therapeutic implications in the treatment of certain nutrient-restricted diseases.
Tue Oct 25 00:00:00 EDT 2022
An AAV-based, room-temperature-stable, single-dose COVID-19 vaccine provides durable immunogenicity and protection in non-human primates.
Cell host & microbe
Zabaleta N,Dai W,Bhatt U,Hérate C,Maisonnasse P,Chichester JA,Sanmiguel J,Estelien R,Michalson KT,Diop C,Maciorowski D,Dereuddre-Bosquet N,Cavarelli M,Gallouët AS,Naninck T,Kahlaoui N,Lemaitre J,Qi W,Hudspeth E,Cucalon A,Dyer CD,Pampena MB,Knox JJ,LaRocque RC,Charles RC,Li D,Kim M,Sheridan A,Storm N,Johnson RI,Feldman J,Hauser BM,Contreras V,Marlin R,Tsong Fang RH,Chapon C,van der Werf S,Zinn E,Ryan A,Kobayashi DT,Chauhan R,McGlynn M,Ryan ET,Schmidt AG,Price B,Honko A,Griffiths A,Yaghmour S,Hodge R,Betts MR,Freeman MW,Wilson JM,Le Grand R,Vandenberghe LH
45-5825-82 was used in Flow Cytometry to show that AAVCOVID-1, an adeno-associated viral (AAV), spike-gene-based vaccine candidate demonstrates potent immunogenicity in mouse and non-human primates following a single injection and confers complete protection from SARS-CoV-2 challenge in macaques.
Wed Sep 08 00:00:00 EDT 2021
ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation.
Cellular & molecular immunology
Liu Y,Bockermann R,Hadi M,Safari I,Carrion B,Kveiborg M,Issazadeh-Navikas S
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Sun Aug 01 00:00:00 EDT 2021
Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.
The Journal of international medical research
Li W,Luo Y,Xu H,Ma Q,Yao Q
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection.
Nature communications
Zhao Z,Wang H,Shi M,Zhu T,Pediongco T,Lim XY,Meehan BS,Nelson AG,Fairlie DP,Mak JYW,Eckle SBG,de Lima Moreira M,Tumpach C,Bramhall M,Williams CG,Lee HJ,Haque A,Evrard M,Rossjohn J,McCluskey J,Corbett AJ,Chen Z
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Fri Jul 16 00:00:00 EDT 2021
Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack.
Cell reports. Medicine
Bonilla WV,Kirchhammer N,Marx AF,Kallert SM,Krzyzaniak MA,Lu M,Darbre S,Schmidt S,Raguz J,Berka U,Vincenti I,Pauzuolis M,Kerber R,Hoepner S,Günther S,Magnus C,Merkler D,Orlinger KK,Zippelius A,Pinschewer DD
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Tue Mar 16 00:00:00 EDT 2021
Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.
Cell reports
Budhu S,Giese R,Gupta A,Fitzgerald K,Zappasodi R,Schad S,Hirschhorn D,Campesato LF,De Henau O,Gigoux M,Liu C,Mazo G,Deng L,Barker CA,Wolchok JD,Merghoub T
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Culture, expansion, and flow-cytometry-based functional analysis of pteropid bat MR1-restricted unconventional T cells.
STAR protocols
Sia WR,Hey YY,Foo R,Wang LF,Leeansyah E
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Fri Jun 18 00:00:00 EDT 2021
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.
Frontiers in immunology
Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Tue Jan 11 00:00:00 EST 2022
Graded RhoA GTPase Expression in Treg Cells Distinguishes Tumor Immunity From Autoimmunity.
Frontiers in immunology
Kalim KW,Yang JQ,Modur V,Nguyen P,Li Y,Zheng Y,Guo F
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Tue Jan 11 00:00:00 EST 2022
Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function.
Cell reports
Daneshmandi S,Cassel T,Lin P,Higashi RM,Wulf GM,Boussiotis VA,Fan TW,Seth P
45-5825-82 was used in Flow cytometry/Cell sorting to show that genetic ablation or pharmacologic inhibition of the PPP enzyme 6-phosphogluconate dehydrogenase (6PGD) in the oxidative PPP results in the generation of superior CD8+ T effector cells.
Tue Mar 09 00:00:00 EST 2021
Immunogenicity of an AAV-based, room-temperature stable, single dose COVID-19 vaccine in mice and non-human primates.
bioRxiv : the preprint server for biology
Zabaleta N,Dai W,Bhatt U,Chichester JA,Sanmiguel J,Estelien R,Michalson KT,Diop C,Maciorowski D,Qi W,Hudspeth E,Cucalon A,Dyer CD,Pampena MB,Knox JJ,LaRocque RC,Charles RC,Li D,Kim M,Sheridan A,Storm N,Johnson RI,Feldman J,Hauser BM,Zinn E,Ryan A,Kobayashi DT,Chauhan R,McGlynn M,Ryan ET,Schmidt AG,Price B,Honko A,Griffiths A,Yaghmour S,Hodge R,Betts MR,Freeman MW,Wilson JM,Vandenberghe LH
45-5825-82 was used in Flow Cytometry to show that this methodology holds as a very promising single dose, thermostable vaccine platform well-suited to address emerging pathogens on a global scale.
Tue Jan 19 00:00:00 EST 2021
MiR-1165-3p Suppresses Th2 Differentiation via Targeting IL-13 and PPM1A in a Mouse Model of Allergic Airway Inflammation.
Allergy, asthma & immunology research
Wang Z,Ji N,Chen Z,Sun Z,Wu C,Yu W,Hu F,Huang M,Zhang M
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2020
CD19-CAR-T Cells Bearing a KIR/PD-1-Based Inhibitory CAR Eradicate CD19+HLA-C1- Malignant B Cells While Sparing CD19+HLA-C1+ Healthy B Cells.
Cancers
Tao L,Farooq MA,Gao Y,Zhang L,Niu C,Ajmal I,Zhou Y,He C,Zhao G,Yao J,Liu M,Jiang W
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Sun Sep 13 00:00:00 EDT 2020
Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants.
Cell reports. Medicine
Marinaik CB,Kingstad-Bakke B,Lee W,Hatta M,Sonsalla M,Larsen A,Neldner B,Gasper DJ,Kedl RM,Kawaoka Y,Suresh M
45-5825 was used in Flow cytometry/Cell sorting to provide further insights into vaccine-induced multifaceted mucosal T cell immunity with implications in the development of vaccines against respiratorypathogens, including influenza virus and SARS-CoV-2.
Tue Sep 22 00:00:00 EDT 2020
Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants.
Cell reports. Medicine
Marinaik CB,Kingstad-Bakke B,Lee W,Hatta M,Sonsalla M,Larsen A,Neldner B,Gasper DJ,Kedl RM,Kawaoka Y,Suresh M
45-5825 was used in Flow cytometry/Cell sorting to provide further insights into vaccine-induced multifaceted mucosal T cell immunity with implications in the development of vaccines against respiratorypathogens, including influenza virus and SARS-CoV-2.
Tue Sep 22 00:00:00 EDT 2020
Th2 Biased Immunity With Altered B Cell Profiles in Circulation of Patients With Sporotrichosis Caused by Sporothrix globosa.
Frontiers in immunology
Zu J,Yao L,Song Y,Cui Y,Guan M,Chen R,Zhen Y,Li S
45-5825 was used in Flow cytometry/Cell sorting to shed light on the potential involvement of peripheral T and B cell immunity against this mycotic infection.
Mon May 31 00:00:00 EDT 2021
Th2 Biased Immunity With Altered B Cell Profiles in Circulation of Patients With Sporotrichosis Caused by Sporothrix globosa.
Frontiers in immunology
Zu J,Yao L,Song Y,Cui Y,Guan M,Chen R,Zhen Y,Li S
45-5825 was used in Flow cytometry/Cell sorting to shed light on the potential involvement of peripheral T and B cell immunity against this mycotic infection.
Mon May 31 00:00:00 EDT 2021
Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity.
Nature communications
Kimura S,Nakamura Y,Kobayashi N,Shiroguchi K,Kawakami E,Mutoh M,Takahashi-Iwanaga H,Yamada T,Hisamoto M,Nakamura M,Udagawa N,Sato S,Kaisho T,Iwanaga T,Hase K
45-5825 was used in Flow cytometry/Cell sorting to identify that the balance between infectious risk and the ability to perform immunosurveillance at the mucosal surface is dependent on osteprotegerin-dependent self-regulation of M cell differentiation.
Mon Jan 13 00:00:00 EST 2020
Adjuvant-free nanofiber vaccine induces in situ lung dendritic cell activation and TH17 responses.
Science advances
Si Y,Tian Q,Zhao F,Kelly SH,Shores LS,Camacho DF,Sperling AI,Andrade MS,Collier JH,Chong AS
45-5825 was used in Flow cytometry/Cell sorting to show that antigens displayed on self-assembling nanofiber scaffolds and delivered intranasally are presented by CD103+ and CD11b+ lung dendritic cells that up-regulate CD80 and migrate into the draining lymph node (LN).
Sat Aug 01 00:00:00 EDT 2020
Adjuvant-free nanofiber vaccine induces in situ lung dendritic cell activation and TH17 responses.
Science advances
Si Y,Tian Q,Zhao F,Kelly SH,Shores LS,Camacho DF,Sperling AI,Andrade MS,Collier JH,Chong AS
45-5825 was used in Flow cytometry/Cell sorting to show that antigens displayed on self-assembling nanofiber scaffolds and delivered intranasally are presented by CD103+ and CD11b+ lung dendritic cells that up-regulate CD80 and migrate into the draining lymph node (LN).
Sat Aug 01 00:00:00 EDT 2020
Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells.
Immunity
Pokrovskii M,Hall JA,Ochayon DE,Yi R,Chaimowitz NS,Seelamneni H,Carriero N,Watters A,Waggoner SN,Littman DR,Bonneau R,Miraldi ER
45-5825 was used in Flow cytometry/Cell sorting to study regulatory interactions between transcription factors and genes within intestinal type 1, 2, and 3 innate lymphoid cells subsets.
Tue Jul 16 00:00:00 EDT 2019
FCRL5+ Memory B Cells Exhibit Robust Recall Responses.
Cell reports
Kim CC,Baccarella AM,Bayat A,Pepper M,Fontana MF
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Tue Apr 30 00:00:00 EDT 2019
Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis.
Cell reports
Pyaram K,Kumar A,Kim YH,Noel S,Reddy SP,Rabb H,Chang CH
45-5825 was used in Flow cytometry/Cell sorting to report that T cellspecific deletion of Keap1 results in defective development and reduced numbers of invariant natural killer T (NKT) cells in the thymus and the peripheral organs in a cell-intrinsic manner.
Tue Apr 16 00:00:00 EDT 2019
Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis.
Cell reports
Pyaram K,Kumar A,Kim YH,Noel S,Reddy SP,Rabb H,Chang CH
45-5825 was used in Flow cytometry/Cell sorting to report that T cellspecific deletion of Keap1 results in defective development and reduced numbers of invariant natural killer T (NKT) cells in the thymus and the peripheral organs in a cell-intrinsic manner.
Tue Apr 16 00:00:00 EDT 2019
Single-Cell Profiling Defines Transcriptomic Signatures Specific to Tumor-Reactive versus Virus-Responsive CD4+ T Cells.
Cell reports
Magen A,Nie J,Ciucci T,Tamoutounour S,Zhao Y,Mehta M,Tran B,McGavern DB,Hannenhalli S,Bosselut R
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Tue Dec 03 00:00:00 EST 2019
The Obese Liver Environment Mediates Conversion of NK Cells to a Less Cytotoxic ILC1-Like Phenotype.
Frontiers in immunology
Cuff AO,Sillito F,Dertschnig S,Hall A,Luong TV,Chakraverty R,Male V
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Wed Oct 21 00:00:00 EDT 2020
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response.
Cell metabolism
Chatterjee S,Daenthanasanmak A,Chakraborty P,Wyatt MW,Dhar P,Selvam SP,Fu J,Zhang J,Nguyen H,Kang I,Toth K,Al-Homrani M,Husain M,Beeson G,Ball L,Helke K,Husain S,Garrett-Mayer E,Hardiman G,Mehrotra M,Nishimura MI,Beeson CC,Bupp MG,Wu J,Ogretmen B,Paulos CM,Rathmell J,Yu XZ,Mehrotra S
45-5825 was used in Flow cytometry/Cell sorting to establish ex vivo culture conditions to generate hybrid Th1/17 cells, which persist long-term in vivo while maintaining effector function.
Tue Jan 09 00:00:00 EST 2018
TRPM2 Exacerbates Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis by Increasing Production of CXCL2 Chemokines.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tsutsui M,Hirase R,Miyamura S,Nagayasu K,Nakagawa T,Mori Y,Shirakawa H,Kaneko S
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Wed Sep 26 00:00:00 EDT 2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.
Nature communications
Kim DH,Park HJ,Lim S,Koo JH,Lee HG,Choi JO,Oh JH,Ha SJ,Kang MJ,Lee CM,Lee CG,Elias JA,Choi JM
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Mon Feb 05 00:00:00 EST 2018
Effects of Anti-Integrin Treatment With Vedolizumab on Immune Pathways and Cytokines in Inflammatory Bowel Diseases.
Frontiers in immunology
Rath T,Billmeier U,Ferrazzi F,Vieth M,Ekici A,Neurath MF,Atreya R
45-5825 was used in Flow cytometry/Cell sorting to identify genetic, cellular, and immunological mechanisms that define response and failure to vedolizumab treatment.
Mon Sep 09 00:00:00 EDT 2019
Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity.
Frontiers in immunology
Araujo Furlan CL,Tosello Boari J,Rodriguez C,Canale FP,Fiocca Vernengo F,Boccardo S,Beccaria CG,Adoue V,Joffre O,Gruppi A,Montes CL,Acosta Rodriguez EV
45-5825 was used in Flow cytometry/Cell sorting to study the role of regulatory T cells during Trypanosoma cruzi infection.
Thu Sep 26 00:00:00 EDT 2019
The NLRP3 inflammasome contributes to host protection during Sporothrix schenckii infection.
Immunology
Gonçalves AC,Ferreira LS,Manente FA,de Faria CMQG,Polesi MC,de Andrade CR,Zamboni DS,Carlos IZ
Thu Jun 01 00:00:00 EDT 2017
Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer's disease.
Scientific reports
Minter MR,Hinterleitner R,Meisel M,Zhang C,Leone V,Zhang X,Oyler-Castrillo P,Zhang X,Musch MW,Shen X,Jabri B,Chang EB,Tanzi RE,Sisodia SS
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Tue Sep 05 00:00:00 EDT 2017
Conventional NK cells and ILC1 are partially ablated in the livers of Ncr1 iCreTbx21 fl/fl mice.
Wellcome open research
Cuff AO,Male V
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Sat Jan 09 00:00:00 EST 2021
Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22.
Nature communications
Brownlie RJ,Garcia C,Ravasz M,Zehn D,Salmond RJ,Zamoyska R
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Tue Nov 07 00:00:00 EST 2017
CD36 receptor regulates malaria-induced immune responses primarily at early blood stage infection contributing to parasitemia control and resistance to mortality.
The Journal of biological chemistry
Thylur RP,Wu X,Gowda NM,Punnath K,Neelgund SE,Febbraio M,Gowda DC
Fri Jun 02 00:00:00 EDT 2017
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Cell
Clever D,Roychoudhuri R,Constantinides MG,Askenase MH,Sukumar M,Klebanoff CA,Eil RL,Hickman HD,Yu Z,Pan JH,Palmer DC,Phan AT,Goulding J,Gattinoni L,Goldrath AW,Belkaid Y,Restifo NP
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Thu Aug 25 00:00:00 EDT 2016
B-cell anergy induces a Th17 shift in a novel B lymphocyte transgenic NOD mouse model, the 116C-NOD mouse.
European journal of immunology
Carrascal J,Carrillo J,Arpa B,Egia-Mendikute L,Rosell-Mases E,Pujol-Autonell I,Planas R,Mora C,Mauricio D,Ampudia RM,Vives-Pi M,Verdaguer J
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2016
Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor Cells.
Journal of immunology (Baltimore, Md. : 1950)
Younis RH,Han KL,Webb TJ
45-5825 was used in Flow cytometry/Cell sorting to examine the role of human head and neck squamous cell carcinoma-secreted Sema4D on myeloid cell differentiation.
Mon Feb 01 00:00:00 EST 2016
CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFNγ production and tumor control.
Oncoimmunology
Veinotte L,Gebremeskel S,Johnston B
45-5825 was used in Flow cytometry/Cell sorting to study the co-stimulatory role of CXCR6/CXCL16 interactions in glycolipid-dependent invariant natural killer T (iNKT) cell activation and tumour control, showing that CXCL16-positive dendritic cells enhance iNKT cell-dependent IFNγ production and tumor control.
Wed Jun 01 00:00:00 EDT 2016
IL12-mediated sensitizing of T-cell receptor-dependent and -independent tumor cell killing.
Oncoimmunology
Braun M,Ress ML,Yoo YE,Scholz CJ,Eyrich M,Schlegel PG,Wölfl M
45-5825 was used in Flow cytometry/Cell sorting to investigate how IL12, and other inflammatory cytokines, shape effector functions of human T-cells.
Fri Jul 01 00:00:00 EDT 2016
The transduction pattern of IL-12-encoding lentiviral vectors shapes the immunological outcome.
European journal of immunology
Goyvaerts C,Broos K,Escors D,Heirman C,Raes G,De Baetselier P,Thielemans K,Breckpot K
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2015
The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Soukup K,Halfmann A,Le Bras M,Sahin E,Vittori S,Poyer F,Schuh C,Luger R,Niederreiter B,Haider T,Stoiber D,Blüml S,Schabbauer G,Kotlyarov A,Gaestel M,Felzmann T,Dohnal AM
45-5825 was used in Flow cytometry/Cell sorting to investigate the role of MK2 in dendritic cells, showing that it attenuates dendritic cell-mediated Th1 differentiation and autoimmune encephalomyelitis.
Wed Jul 15 00:00:00 EDT 2015
Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-β Therapy.
Journal of immunology (Baltimore, Md. : 1950)
Rasouli J,Ciric B,Imitola J,Gonnella P,Hwang D,Mahajan K,Mari ER,Safavi F,Leist TP,Zhang GX,Rostami A
45-5825 was used in Flow cytometry/Cell sorting to characterise GM-CSF production by T cells of MS patients and to determine the effect of IFN-β therapy on its production.
Mon Jun 01 00:00:00 EDT 2015
Intranasal Administration of Lentiviral miR-135a Regulates Mast Cell and Allergen-Induced Inflammation by Targeting GATA-3.
PloS one
Deng YQ,Yang YQ,Wang SB,Li F,Liu MZ,Hua QQ,Tao ZZ
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Tue May 31 00:00:00 EDT 2016
Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors.
Oncotarget
Colbeck EJ,Hindley JP,Smart K,Jones E,Bloom A,Bridgeman H,McPherson RC,Turner DG,Ladell K,Price DA,O'Connor RA,Anderton SM,Godkin AJ,Gallimore AM
45-5825 was used in Flow cytometry/Cell sorting to study the enrichment of tumor-infiltrating Treg populations and assess the role of IL-2 in pertubation of Treg frequencies in tumors.
Tue Sep 22 00:00:00 EDT 2015
IL-10 inhibits neuraminidase-activated TGF-β and facilitates Th1 phenotype during early phase of infection.
Nature communications
Dutta A,Huang CT,Chen TC,Lin CY,Chiu CH,Lin YC,Chang CS,He YC
45-5825 was used in Flow cytometry/Cell sorting to reveal a previously unrecognized function of Th1 cell-derived IL-10 in vivo.
Mon Mar 02 00:00:00 EST 2015
Chronic Trichuris muris Infection Decreases Diversity of the Intestinal Microbiota and Concomitantly Increases the Abundance of Lactobacilli.
PloS one
Holm JB,Sorobetea D,Kiilerich P,Ramayo-Caldas Y,Estellé J,Ma T,Madsen L,Kristiansen K,Svensson-Frej M
45-5825 was used in Flow cytometry/Cell sorting to study the influence of chronic parasite infection on the intestinal microbiota and the adaptive immune system.
Wed Feb 03 00:00:00 EST 2016
MicroRNA-155 is essential for T(H)2-mediated allergen-induced eosinophilic inflammation in the lung.
The Journal of allergy and clinical immunology
Malmhäll C,Alawieh S,Lu Y,Sjöstrand M,Bossios A,Eldh M,Rådinger M
45-5825 was used in Flow cytometry/Cell sorting to investigate the contribution of microRNA-155 to TH2-mediated allergen-induced airway inflammation in a mouse model.
Thu May 01 00:00:00 EDT 2014
CD4CD8αα lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease.
PLoS biology
Sarrabayrouse G,Bossard C,Chauvin JM,Jarry A,Meurette G,Quévrain E,Bridonneau C,Preisser L,Asehnoune K,Labarrière N,Altare F,Sokol H,Jotereau F
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Tue Apr 01 00:00:00 EDT 2014
High eomesodermin expression among CD57+ CD8+ T cells identifies a CD8+ T cell subset associated with viral control during chronic human immunodeficiency virus infection.
Journal of virology
Simonetta F,Hua S,Lécuroux C,Gérard S,Boufassa F,Sáez-Cirión A,Pancino G,Goujard C,Lambotte O,Venet A,Bourgeois C
45-5825 was used in Flow cytometry/Cell sorting to investigate the phenotype of CD57-expressing CD8(+) T cells in healthy donors and during HIV infection combining CD57 expression to Eomesodermin.
Wed Oct 01 00:00:00 EDT 2014
Prophylaxis with a respiratory syncytial virus (RSV) anti-G protein monoclonal antibody shifts the adaptive immune response to RSV rA2-line19F infection from Th2 to Th1 in BALB/c mice.
Journal of virology
Boyoglu-Barnum S,Chirkova T,Todd SO,Barnum TR,Gaston KA,Jorquera P,Haynes LM,Tripp RA,Moore ML,Anderson LJ
45-5825 was used in Flow cytometry/Cell sorting to suggest that the RSV G protein not only contributes to disease, but also dampens the host immune response to infection.
Mon Sep 01 00:00:00 EDT 2014
T cell factor-1 controls the lifetime of CD4+ CD8+ thymocytes in vivo and distal T cell receptor α-chain rearrangement required for NKT cell development.
PloS one
Sharma A,Berga-Bolaños R,Sen JM
45-5825 was used in Flow cytometry/Cell sorting to demonstrate that T cell factor-1, encoded by the Tcf7 gene, is critical for the extended lifetime of double positive thymocytes.
Fri Apr 29 00:00:00 EDT 2016
Proinflammatory Vδ2+ T cells populate the human intestinal mucosa and enhance IFN-γ production by colonic αβ T cells.
Journal of immunology (Baltimore, Md. : 1950)
McCarthy NE,Bashir Z,Vossenkämper A,Hedin CR,Giles EM,Bhattacharjee S,Brown SG,Sanders TJ,Whelan K,MacDonald TT,Lindsay JO,Stagg AJ
45-5825 was used in Flow cytometry/Cell sorting to characterise a novel subset of human Vδ2T cells that populate the human intestinal mucosa and contribute to mucosal inflammation.
Sun Sep 01 00:00:00 EDT 2013
Helicobacter pylori infection in a pig model is dominated by Th1 and cytotoxic CD8+ T cell responses.
Infection and immunity
Kronsteiner B,Bassaganya-Riera J,Philipson C,Viladomiu M,Carbo A,Pedragosa M,Vento S,Hontecillas R
45-5825 was used in Flow cytometry/Cell sorting to investigate the phenotypic and functional changes in PMBC populations during Helicobacter pylori infection, showing that infection is dominated by Th1 and cytotoxic CD8+ T cell responses.
Tue Oct 01 00:00:00 EDT 2013
Alterations in regulatory T cells induced by specific oligosaccharides improve vaccine responsiveness in mice.
PloS one
Schijf MA,Kerperien J,Bastiaans J,Szklany K,Meerding J,Hofman G,Boon L,van Wijk F,Garssen J,Van't Land B
45-5825 was used in Flow cytometry/Cell sorting to identify factors affecting the quality of the immune response to vaccination.
Tue May 27 00:00:00 EDT 2014
Breakdown in repression of IFN-γ mRNA leads to accumulation of self-reactive effector CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Chang PP,Lee SK,Hu X,Davey G,Duan G,Cho JH,Karupiah G,Sprent J,Heath WR,Bertram EM,Vinuesa CG
45-5825 was used in Flow cytometry/Cell sorting to identify a novel mechanism that affects the distribution of self-reactive cytotoxic effector cells.
Sun Jul 15 00:00:00 EDT 2012
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.
The Journal of experimental medicine
Randall KL,Chan SS,Ma CS,Fung I,Mei Y,Yabas M,Tan A,Arkwright PD,Al Suwairi W,Lugo Reyes SO,Yamazaki-Nakashimada MA,Garcia-Cruz Mde L,Smart JM,Picard C,Okada S,Jouanguy E,Casanova JL,Lambe T,Cornall RJ,Russell S,Oliaro J,Tangye SG,Bertram EM,Goodnow CC
45-5825 was used in Flow cytometry/Cell sorting to study the role of DOCK8 in the survival and function of human and mouse CD8 T cells.
Mon Oct 24 00:00:00 EDT 2011
CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Qui HZ,Hagymasi AT,Bandyopadhyay S,St Rose MC,Ramanarasimhaiah R,Ménoret A,Mittler RS,Gordon SM,Reiner SL,Vella AT,Adler AJ
45-5825 was used in Flow cytometry/Cell sorting to investigate the pathways that govern differentiation of cytotoxic CD4 Th1 cells.
Sat Oct 01 00:00:00 EDT 2011
Increase in Th17 and T-reg lymphocytes and decrease of IL22 correlate with the recovery phase of acute EAE in rat.
PloS one
Almolda B,Costa M,Montoya M,González B,Castellano B
45-5825 was used in Flow cytometry/Cell sorting to reveal a unique pattern of lymphocyte infiltration and cytokine secretion in the acute experimental autoimmune encephalomyelitis model in Lewis rat.
Mon Mar 26 00:00:00 EDT 2012
Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cells.
PloS one
Yabas M,Godfrey DI,Goodnow CC,Hoyne GF
45-5825 was used in Flow cytometry/Cell sorting to investigate the effect of mutations in heterogeneous ribonucleoprotein L-like protein on NKT and T cells.
Mon Mar 26 00:00:00 EDT 2012
Cytokine requirements for the differentiation and expansion of IL-17A- and IL-22-producing human Vgamma2Vdelta2 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Ness-Schwickerath KJ,Jin C,Morita CT
Published figure using T-bet monoclonal antibody (Product # 45-5825-82) in Flow Cytometry
Tue Jun 15 00:00:00 EDT 2010
