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Hear about the evaluation and optimization of two NGS panels using phenotypic, ancestry-specific, and mtDNA markers and a discussion about their potential application in forensic genetics.
Within the Forensic DNA community, the development of technology for Forensic DNA Phenotyping (FDP) is rapidly growing due to the unique intelligence it can provide for criminal investigations, missing persons cases and disaster victim identification. FDP involves the inference of an individual’s genetic ancestry (BGA) and of externally visible characteristics (EVCs), for example, eye, hair or skin color. Queensland Health Forensic DNA Analysis completed research which demonstrated that the use of Massively Parallel Sequencing (MPS) to predict BGA and EVCs would be operationally effective for criminal investigations to prioritize persons of interest (POI), utilizing the Ion Chef and Ion GeneStudio S5 Plus instruments.
A group of experts from Munich and Innsbruck, working with the Association for the Recovery of the Fallen in Eastern Europe, decided to utilize cutting-edge forensic techniques to help identify the killed soldiers. From golden standard STR typing with capillary electrophoresis to mitochondrial whole genome sequencing and forensic DNA phenotyping with Next Generation Sequencing – all methods are evaluated in their capacity to assist the process.
Luke Ryan, Queensland Health, Forensic, and Scientific Services, discusses the usefulness of biogeographical ancestry and externally visible traits using NGS for generating investigative leads in criminal casework.
Dr. Marta Diepenbroek, Institute of Legal Medicine, Munich, describes her validation of the custom Molecular identi-kit, which combines ancestry-informative autosomal and Y-chromosomal SNPs with phenotype prediction.
Executive Director Soizic Le-Gunier discusses how Institute Genetics Nantes Atlantique (IGNA) uses the various technology options and how SNP genotyping will have an impact in the future.
Jennifer Churchill, PhD, Research Assistant Professor at the University of North Texas, provides guidance for bringing mtDNA analysis into casework operations.
Walther Parson, PhD, from the Institute of Legal Medicine, Innsbruck Medical University, discusses a number of cases his lab has worked on using mtDNA analysis to make critical identifications.
Dr. Pedro Barrio, a DNA expert with the National Institute of Toxicology and Forensic Sciences in Madrid, Spain, describes his experience working with mixtures using NGS to get more information from his samples.
Dr. Bruce Budowle, University of North Texas Health Science Center
Dr. Walther Parson, Institute of Legal Medicine at Innsbruck Medical University
Joseph Chang, Thermo Fisher Scientific