CaptureSelect and POROS Purification Solutions

We work with you, so our resins work for you.

At Thermo Fisher Scientific, we are here to help you improve your purification process efficiency. In a complex world of biopharmaceuticals, vaccines, and gene therapies, you need a provider that is as focused as you are on delivering results. Our comprehensive resin portfolio is designed to help deliver innovative solutions that are scalable, and easily integrated into your platform to improve your process efficiency.

A platform for purification of all biotherapeutics

Enabling high purity, helping deliver superior resolution, and designed for high throughput applications, our novel CaptureSelect and POROS resin technologies address today’s challenges in your purification workflow.  

Thermo Fisher Scientific is your provider in purification.

• Years of experience: Leverage our years of experience as a world leader in serving science, with decades of involvement in FDA review of novel molecules.
• Support at every stage: Engage our field application scientists to support your team through process development and scale up to commercial manufacturing. They are on hand to help assess your needs and solve complex purification challenges, which can save you time and money.
• Comprehensive catalog of scalable resins: Integrate resins that are scalable, compatible with the equipment you already have, and designed for cGMP biotherapeutic manufacturing. We also offer custom resin development programs for tailored purification solutions.

Thermo Scientific POROS anion exchange and cation exchange resins are the industry standard for large-scale polish chromatography applications. These POROS resins allow target molecule binding and impurity removal over a broad range of process conditions, thereby increasing process flexibility and manufacturing throughput.

Our affinity resins are designed to deliver high purity and high yield of your target molecule in a single capture step. They are scalable and useful from bench-scale process development to commercial manufacturing of antibody therapeutics, biosimilars and recombinant proteins, vaccines, and gene therapies.

Browse our suite of POROS HIC resins offering a differentiating range in hydrophobicity suitable for bind/elute and flow-through applications. These resins can be utilized at lower salt concentrations for the purification of a wide variety of biomolecules.

The manufacture of complex biotherapeutics requires novel purification strategies. Our custom ligand and chromatography resin services enable the development of innovative purification resins.

To support the manufacturing of cell and gene therapies, we’ve developed innovative chromatography solutions, specifically designed to improve the downstream purification of mRNA and viral vectors such as the Adeno-Associated Virus (AAV), lentivirus, and Adv5.

Our CaptureSelect antibody subdomain-specific affinity chromatography resins are developed for the downstream purification of novel antibody modalities, such as bi-specific monoclonal antibodies, Fab fragments and Fc-fusion proteins, and can facilitate the process scale purification of a variety of antibody formats for commercial production of therapeutics.

We’ve developed a unique portfolio of affinity resins to help you develop biosimilars, biobetters, and other types of recombinant proteins.

Thermo Scientific CaptureSelect and POROS resin technologies address purification challenges in the vaccine production workflow. We offer a variety of efficient and scalable resins for affinity, ion exchange, and hydrophobic interaction chromatography applications.

Case studies, webinars, and articles spotlighting Thermo Fisher Scientific purification solutions.