Search Thermo Fisher Scientific
- Contáctenos
- Orden Rápida
-
¿No tiene una cuenta? Crear una cuenta
Orbitrap LC-MS Comparison Chart
Choose from an extensive portfolio of Thermo Scientific high-resolution, accurate-mass (HRAM) Orbitrap mass analyzers. Our Orbitrap-based MS systems connect to liquid chromatography instruments to enhance separation of unknown and known compounds and enable high-throughput workflows. Compare products below to find the Thermo Scientific Orbitrap LC-MS instruments that best meet your analysis needs.
Choose a high-resolution, accurate-mass (HRAM) Orbitrap mass spectrometer that offers reliable screening performance with quantitative capability to take on more of your testing requirements that require confident, reportable results.
 |  | |
| Q Exactive Plus MS | Orbitrap Exploris 120 MS | |
|---|---|---|
| Ideal Applications | Forensic Toxicology, Clinical Research, Food & Environmental Safety Research, Basic Academic Research, Sport Anti-Doping, Biopharma development, Metabolomics, Lipidomics | Forensic Toxicology, Clinical Research, Food & Environmental Safety Testing, Basic Academic Research, Targeted/semi-targeted Metabolomics, Pharmaceuticals |
| Analyses | Unknown identification & confirmation, non-targeted and targeted screening and targeted quantitation | |
| Next-generation ion source interface | N/A | Yes |
| Quick start methods for various applications | N/A | Yes |
| Drag-n-drop method setup user interface | N/A | Yes |
| AcquireX Intelligent data acquisition | N/A | |
| Standard Features | ||
| Resolving Power @ m/z 200 | 140,000 (up to 280,000 with BioPharma option) | 120,000 |
| Mass Accuracy (Internal Calibration) | <1 ppm with internal calibration | <1 ppm for at least 5 days with EASY-IC ion source |
| Calibration procedures | Traditional Calmix | One-click calibration with FlexMix calibration solution |
| Mass Range | m/z 50 - 6,000 (up to 8000 with BioPharma option) | m/z 40 - 3,000 |
| Scan Speed | 12 Hz | 22 Hz |
| Dynamic Range | Up to 5 orders | |
| Ion Source interface | IonMax with H-ESI II probe | OptaMax NG ion source |
| Polarity Switching | 1 Hz | 1.4 Hz |
| Multiplexing | 10 | 20 |
| Scan Functions | Full-MS, AIF, SIM, PRM, (t-MS2 for Orbitrap Exploris 120), DIA | |
| Dissociation | In-source CID, HCD | |
| Optional Upgrades | ||
| Intact Protein Mode | Yes | N/A |
| Enhanced Resolution Mode | Yes | N/A |
| Sources | APCI/APPI Combination Ion Source EASY-Spray Sources Nanospray Flex Ion Sources | APCI/APPI Combination Ion Source EASY-Spray Sources Nanospray Flex Ion Sources |
For more information
Choose the high performance, high-resolution, accurate-mass (HRAM) Orbitrap mass spectrometer that's right for your translational research lab
 |  |  | ||
| Orbitrap Exploris 240 | Orbitrap Exploris 480 | Q Exactive UHMR | ||
|---|---|---|---|---|
| Ideal Applications | Forensic Toxicology, Sport Anti-Doping, Food & Environmental Safety research and emerging contaminant testing, Extractables & Leachables, Academic Research, Biopharma development, Semi-targeted Metabolomics, Lipidomics, Clinical & Translational Research | Quantitative Proteomics, Protein Identification, Biopharma R&D, Clinical & Translational Research | Proteomics, Structural Biology, Protein Characterization | |
| Analyses | MS and MS/MS, Qual/Quan, Screening & Confirmation | MS and MS/MS, Screening & Confirmation | ||
| Advanced Data-Dependent Experiments | Precursor Fit | SureQuant, Precursor Fit, Boxcar Scanning | N/A | |
| Next-generation ion source interface | Yes | N/A | ||
| Quick start methods for various applications | Yes | N/A | ||
| Drag-and-drop method setup user interface | Yes | N/A | ||
| AcquireX intelligent data acquisition | Yes | N/A | ||
| Standard Features | ||||
| Resolving Power @ m/z 200 | 240,000 | 480,000 | 200,000 at m/z 400 | |
| Mass Accuracy (Internal Calibration) | <1 ppm for up to 5 days with EASY-IC ion source | <1 ppm internal calibration | ||
| Calibration procedures | One-click calibration with FlexMix calibration solution | Traditional Calmix | ||
| EASY-IC Ion Source | <1 ppm for up to 5 days | N/A | ||
| Dynamic Range | Up to 5 orders | |||
| Mass Range | m/z 40 - 6000 (up to 8000 with BioPharma option) | m/z 40 - 6000 (up to 8000 with BioPharma option) | m/z 350 - 80,000 | |
| Scan Speed | Up to 22 Hz | Up to 40 Hz | Up to 12 Hz (at resolution setting of 12,500 @ m/z 400 | |
| Polarity Switching | 1.4 Hz | (1 full cycle <1 sec) | ||
| Ion Source | OptaMax NG ion source | IonMax with H-ESI II probe | ||
| Multiplexing | Up to 20 precursors/scan | N/A | ||
| Scan Functions | FS, AIF, SIM, t-MS2, DIA, ddHCD | FS, AIF, MS/MS, pseudo-MS3 | ||
| Dissociation | In-source CID, HCD | In-source trapping, HCD | ||
| Optional Upgrades | ||||
| Intact Protein Mode | Yes | |||
| High Mass Rangen(HMRn, up to 8000 m/z) | Yes | N/A | ||
| Sources | FAIMS Pro Duo interface APCI/APPI Combination Ion Source EASY-Spray Sources Nanospray Flex Ion Sources VeriSpray PaperSpray Ion Source | APCI/APPI Combination Ion Source EASY-Spray Sources Nanospray Flex Ion Sources | ||
High-Field Asymmetric waveform Ion Mobility Spectrometry (FAIMS) can be used to optimize ion selectivity and reduce chemical backgrounds during mass spectrometry assays. FAIMS selectivity successfully prevents interferences from co-eluting compounds and increases signal to noise ratios by 100-fold or higher.
For more information
Choose the maximum performance Tribrid Orbitrap mass spectrometer that's right for your discovery lab
 |  |  |  | ||
| Orbitrap IQ-X Tribrid MS | Orbitrap Fusion Lumos Tribrid MS | Orbitrap Eclipse Tribrid MS | Orbitrap Ascend Tribrid MS | ||
|---|---|---|---|---|---|
| Ideal Applications | Small molecule characterization and elucidation research for applications such as Metabolomics, Drug development Met ID, Extactables and Leachables, Industrial Environmental Health and more | Multi-omics, TMT, Intact/top-down proteomics, Targeted Quantification, Protein-Protein Crosslinking | Multi-omics, TMT, Intact/top-down proteomics, Targeted Quantification, Protein-Protein Crosslinking, NativeOmics, LC-top-down mass spectrometry, Biotherapeutics | Multi-omics, TMT, Intact/top-down proteomics, Targeted Quantification, Protein-Protein Crosslinking, NativeOmics, LC-top-down mass spectrometry, Biotherapeutics, and new modalities | |
| Analyses | MS and MSn, Qualitative and Quantitative, Profiling, screening, and targeted consistently cap or uncap | ||||
| Advanced Data-Dependent Experiments | Universal Method, Product Ion & Neutral Loss Triggered-MSn, Isolation offset, Intelligent MSn with Real-Time Library Search and Library builder | SPS MS3, Universal Method, Product Ion & Neutral Loss Triggered-MSn, Isolation offset, Quantitation/Confirmation Acquisition, SureQuant | Real-Time Search SPS MS3, Universal Method, Product Ion & Neutral Loss Triggered-MSn, Isolation offset, Quantitation/Confirmation Acquisition, SureQuant, Precursor Fit Filter | Real-Time Search & Real-Time Library Search for small molecules & peptides, Universal Method, Product Ion & Neutral Loss Triggered-MSn, Isolation offset, Quantitation/Confirmation Acquisition, SureQuant, Precursor Fit Filter | |
| AcquireX Acquisition Tool | Requires Thermo Scientific Orbitrap Tribrid Series 4.2 SP1QF1, 3.1 or greater | ||||
| Optional Upgrades | |||||
| EASY-ETD HD | No | Yes | Yes | ||
| UVPD Laser | Yes | Yes | Yes | ||
| High Mass Rangen (HMRn, up to 8,000 m/z) | No | up to m/z 8000 | up to m/z 16000 | ||
| Proton Transfer Charge Reduction (PTCR) | No | Yes | Yes | ||
| EASY-IC Ion Source | Yes | Yes | |||
| 1M Resolution | Yes | Yes | No | ||
| FAIMS Pro Duo Interface | Yes | ||||
 | |||||
| Comprehensive solutions | |||||
|---|---|---|---|---|---|
| Pesticide Explorer Learn about this comprehensive liquid chromatography-mass spectrometry (LC-MS) solution designed to enhance productivity and efficiency using start-to-finish workflows for routine quantitation and pesticide residue screening of food matrices. | |||||
| VetDrugs Explorer Collection Learn about this comprehensive liquid chromatography-mass spectrometry (LC-MS) solution that includes all the essential components for accurate and efficient routine screening or sensitive quantitation of veterinary drugs and antibiotics in food matrices. | |||||
| Automated workflows with uSPE for GC and LC and the TriPlus RSH autosampler Learn about this reliable and high-throughput workflow that automates clean-up of QuEChERS extracts using the cartridge based Thermo Scientific micro-Solid Phase Extraction (µSPE) with subsequent analysis by GC-MS or LC-MS. This µSPE capability, is available for the Thermo Scientific TriPlus RSH Autosampler and LC systems. | |||||
Single-cell proteomics is now a reality
Single-cell proteomics is now a reality
By collaborating with the scientific community, Thermo Fisher Scientific has developed innovations that allow you to perform single-cell proteomics analysis. Access our collection of materials dedicated to single-cell proteomics, including white papers, webinars, poster notes, and more.
For more information
Choose a high-resolution, accurate-mass (HRAM) Orbitrap mass spectrometer that offers reliable screening performance with quantitative capability to take on more of your testing requirements that require confident, reportable results.
| | |
| Q Exactive Plus MS | Orbitrap Exploris 120 MS | |
|---|---|---|
| Ideal Applications | Forensic Toxicology, Clinical Research, Food & Environmental Safety Research, Basic Academic Research, Sport Anti-Doping, Biopharma development, Metabolomics, Lipidomics | Forensic Toxicology, Clinical Research, Food & Environmental Safety Testing, Basic Academic Research, Targeted/semi-targeted Metabolomics, Pharmaceuticals |
| Analyses | Unknown identification & confirmation, non-targeted and targeted screening and targeted quantitation | |
| Next-generation ion source interface | N/A | Yes |
| Quick start methods for various applications | N/A | Yes |
| Drag-n-drop method setup user interface | N/A | Yes |
| AcquireX Intelligent data acquisition | N/A | |
| Standard Features | ||
| Resolving Power @ m/z 200 | 140,000 (up to 280,000 with BioPharma option) | 120,000 |
| Mass Accuracy (Internal Calibration) | <1 ppm with internal calibration | <1 ppm for at least 5 days with EASY-IC ion source |
| Calibration procedures | Traditional Calmix | One-click calibration with FlexMix calibration solution |
| Mass Range | m/z 50 - 6,000 (up to 8000 with BioPharma option) | m/z 40 - 3,000 |
| Scan Speed | 12 Hz | 22 Hz |
| Dynamic Range | Up to 5 orders | |
| Ion Source interface | IonMax with H-ESI II probe | OptaMax NG ion source |
| Polarity Switching | 1 Hz | 1.4 Hz |
| Multiplexing | 10 | 20 |
| Scan Functions | Full-MS, AIF, SIM, PRM, (t-MS2 for Orbitrap Exploris 120), DIA | |
| Dissociation | In-source CID, HCD | |
| Optional Upgrades | ||
| Intact Protein Mode | Yes | N/A |
| Enhanced Resolution Mode | Yes | N/A |
| Sources | APCI/APPI Combination Ion Source EASY-Spray Sources Nanospray Flex Ion Sources | APCI/APPI Combination Ion Source EASY-Spray Sources Nanospray Flex Ion Sources |
For more information
Choose the high performance, high-resolution, accurate-mass (HRAM) Orbitrap mass spectrometer that's right for your translational research lab
| | | ||
| Orbitrap Exploris 240 | Orbitrap Exploris 480 | Q Exactive UHMR | ||
|---|---|---|---|---|
| Ideal Applications | Forensic Toxicology, Sport Anti-Doping, Food & Environmental Safety research and emerging contaminant testing, Extractables & Leachables, Academic Research, Biopharma development, Semi-targeted Metabolomics, Lipidomics, Clinical & Translational Research | Quantitative Proteomics, Protein Identification, Biopharma R&D, Clinical & Translational Research | Proteomics, Structural Biology, Protein Characterization | |
| Analyses | MS and MS/MS, Qual/Quan, Screening & Confirmation | MS and MS/MS, Screening & Confirmation | ||
| Advanced Data-Dependent Experiments | Precursor Fit | SureQuant, Precursor Fit, Boxcar Scanning | N/A | |
| Next-generation ion source interface | Yes | N/A | ||
| Quick start methods for various applications | Yes | N/A | ||
| Drag-and-drop method setup user interface | Yes | N/A | ||
| AcquireX intelligent data acquisition | Yes | N/A | ||
| Standard Features | ||||
| Resolving Power @ m/z 200 | 240,000 | 480,000 | 200,000 at m/z 400 | |
| Mass Accuracy (Internal Calibration) | <1 ppm for up to 5 days with EASY-IC ion source | <1 ppm internal calibration | ||
| Calibration procedures | One-click calibration with FlexMix calibration solution | Traditional Calmix | ||
| EASY-IC Ion Source | <1 ppm for up to 5 days | N/A | ||
| Dynamic Range | Up to 5 orders | |||
| Mass Range | m/z 40 - 6000 (up to 8000 with BioPharma option) | m/z 40 - 6000 (up to 8000 with BioPharma option) | m/z 350 - 80,000 | |
| Scan Speed | Up to 22 Hz | Up to 40 Hz | Up to 12 Hz (at resolution setting of 12,500 @ m/z 400 | |
| Polarity Switching | 1.4 Hz | (1 full cycle <1 sec) | ||
| Ion Source | OptaMax NG ion source | IonMax with H-ESI II probe | ||
| Multiplexing | Up to 20 precursors/scan | N/A | ||
| Scan Functions | FS, AIF, SIM, t-MS2, DIA, ddHCD | FS, AIF, MS/MS, pseudo-MS3 | ||
| Dissociation | In-source CID, HCD | In-source trapping, HCD | ||
| Optional Upgrades | ||||
| Intact Protein Mode | Yes | |||
| High Mass Rangen(HMRn, up to 8000 m/z) | Yes | N/A | ||
| Sources | FAIMS Pro Duo interface APCI/APPI Combination Ion Source EASY-Spray Sources Nanospray Flex Ion Sources VeriSpray PaperSpray Ion Source | APCI/APPI Combination Ion Source EASY-Spray Sources Nanospray Flex Ion Sources | ||
High-Field Asymmetric waveform Ion Mobility Spectrometry (FAIMS) can be used to optimize ion selectivity and reduce chemical backgrounds during mass spectrometry assays. FAIMS selectivity successfully prevents interferences from co-eluting compounds and increases signal to noise ratios by 100-fold or higher.
For more information
Choose the maximum performance Tribrid Orbitrap mass spectrometer that's right for your discovery lab
| | | | ||
| Orbitrap IQ-X Tribrid MS | Orbitrap Fusion Lumos Tribrid MS | Orbitrap Eclipse Tribrid MS | Orbitrap Ascend Tribrid MS | ||
|---|---|---|---|---|---|
| Ideal Applications | Small molecule characterization and elucidation research for applications such as Metabolomics, Drug development Met ID, Extactables and Leachables, Industrial Environmental Health and more | Multi-omics, TMT, Intact/top-down proteomics, Targeted Quantification, Protein-Protein Crosslinking | Multi-omics, TMT, Intact/top-down proteomics, Targeted Quantification, Protein-Protein Crosslinking, NativeOmics, LC-top-down mass spectrometry, Biotherapeutics | Multi-omics, TMT, Intact/top-down proteomics, Targeted Quantification, Protein-Protein Crosslinking, NativeOmics, LC-top-down mass spectrometry, Biotherapeutics, and new modalities | |
| Analyses | MS and MSn, Qualitative and Quantitative, Profiling, screening, and targeted consistently cap or uncap | ||||
| Advanced Data-Dependent Experiments | Universal Method, Product Ion & Neutral Loss Triggered-MSn, Isolation offset, Intelligent MSn with Real-Time Library Search and Library builder | SPS MS3, Universal Method, Product Ion & Neutral Loss Triggered-MSn, Isolation offset, Quantitation/Confirmation Acquisition, SureQuant | Real-Time Search SPS MS3, Universal Method, Product Ion & Neutral Loss Triggered-MSn, Isolation offset, Quantitation/Confirmation Acquisition, SureQuant, Precursor Fit Filter | Real-Time Search & Real-Time Library Search for small molecules & peptides, Universal Method, Product Ion & Neutral Loss Triggered-MSn, Isolation offset, Quantitation/Confirmation Acquisition, SureQuant, Precursor Fit Filter | |
| AcquireX Acquisition Tool | Requires Thermo Scientific Orbitrap Tribrid Series 4.2 SP1QF1, 3.1 or greater | ||||
| Optional Upgrades | |||||
| EASY-ETD HD | No | Yes | Yes | ||
| UVPD Laser | Yes | Yes | Yes | ||
| High Mass Rangen (HMRn, up to 8,000 m/z) | No | up to m/z 8000 | up to m/z 16000 | ||
| Proton Transfer Charge Reduction (PTCR) | No | Yes | Yes | ||
| EASY-IC Ion Source | Yes | Yes | |||
| 1M Resolution | Yes | Yes | No | ||
| FAIMS Pro Duo Interface | Yes | ||||
| |||||
| Comprehensive solutions | |||||
|---|---|---|---|---|---|
| Pesticide Explorer Learn about this comprehensive liquid chromatography-mass spectrometry (LC-MS) solution designed to enhance productivity and efficiency using start-to-finish workflows for routine quantitation and pesticide residue screening of food matrices. | |||||
| VetDrugs Explorer Collection Learn about this comprehensive liquid chromatography-mass spectrometry (LC-MS) solution that includes all the essential components for accurate and efficient routine screening or sensitive quantitation of veterinary drugs and antibiotics in food matrices. | |||||
| Automated workflows with uSPE for GC and LC and the TriPlus RSH autosampler Learn about this reliable and high-throughput workflow that automates clean-up of QuEChERS extracts using the cartridge based Thermo Scientific micro-Solid Phase Extraction (µSPE) with subsequent analysis by GC-MS or LC-MS. This µSPE capability, is available for the Thermo Scientific TriPlus RSH Autosampler and LC systems. | |||||
Single-cell proteomics is now a reality
Single-cell proteomics is now a reality
By collaborating with the scientific community, Thermo Fisher Scientific has developed innovations that allow you to perform single-cell proteomics analysis. Access our collection of materials dedicated to single-cell proteomics, including white papers, webinars, poster notes, and more.
For more information
Definition of terms
Resolution: Frequently reported in full width at half maximum (FWHM), resolution is the separation of two mass spectrometry peaks and is calculated as the mass of a peak (M) divided by resolving power (∆M).
Mass accuracy: Expressed in parts per million, this value indicates how much an instrument deviates from a known standard or calibrant.
Scan rate: Measured in hertz, the scan rate of an MS indicates how quickly it scans a mass spectrum.
Polarity switch: The collection of both positive and negative sample ionization data (spectra) by the ion trap during a single MS analysis. Polarity switching is applied to the study of drugs, drug metabolites, pesticides, etc.
PRM: Parallel reaction monitoring (PRM) is a targeted method of high resolution MS quantification in which a full scan of each precursor ion transition is monitored; i.e., all fragments derived from the precursor ion are monitored. In contrast, single reaction monitoring (SRM) performs one transition monitoring at a time.
Multiplex: The ability of a mass analyzer to acquire data from multiple precursor ions in the same scan without compromising high signal-to-noise ratio.
MSn: Also termed tandem MS, the use of multiple stage MS to capture product ion spectra of a defined m/z, where n is the number of recorded product ion stages.
ETD: Electron transfer dissociation (ETD) results in the fragmentation of the peptide backbone of MS samples, simplifying identification of peptide modification sites.
Synchronous MS3: A method of quantitation that involves simultaneous selection of several MS2 precursors for MS3 analysis and is often used during TMT and iTRAQ experiments.
Keep up with the speed of science
The Lab-Forward Trade-In Program
The world needs science to move faster. Now more than ever. Which is why when more scientists have access to the latest scientific instrumentation, we all benefit. That is the sole purpose of our Lab-Forward Trade-In Program. For a limited time, trade in your chromatography and mass spectrometry instruments and save!
LC-MS webinar series
Expand your application knowledge
Our LC-MS on-demand webinar series expands your application knowledge for pharma, biopharma, environmental, omics, food, forensics and clinical research and more. Learn how the latest high-performance mass spectrometry solutions can enable your laboratory to solve your most pressing analytical challenges, regardless of sample type.