Cell Structure Information | Thermo Fisher Scientific

Find useful articles, videos and tools for studying cell structure using fluorescence microscopy and high-content analysis.

Cell structure features

On-demand webinar

Introduction to basic cytoskeleton labeling and detection

This webinar provides an overview of the cytoskeleton and includes a comprehensive guide to labeling and detection technologies such as live-cell imaging fluorescent dyes, antibodies and the BacMam gene delivery platform.

BioProbes article

Tools to study mitochondrial morphology and function—Multiplex your mitochondrial data

We highlight a few of our most referenced mitochondrial probes for studying cell morphology and function.

Cell structure learning resources

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Type	Title	Categories
Application note (2011)	Apoptosis detection: Apoptosis assays for the Attune Acoustic Focusing Cytometer	Alexa Fluor, apoptosis, Attune/Attune NxT, cell structure-mitochondria, cell structure-plasma membrane, flow cytometer/flow cytometry, fluorescent dyes
Application note (2015)	Collecting Z-stack image sequences with the EVOS FL Auto Imaging System	cell structure-all, CellLight, EVOS FL Auto Microscope, fluorescence microscopy/fluorescence imaging, live-cell imaging, ReadyProbes
BioProbes articles (Issues 50– present day)	BioProbes Journal of Cell Biology Application	cell analysis, flow cytometry, imaging microscopy, immunoassays, antibodies, protein detection and quantification
Molecular Probes Handbook	Mitochondria in diseases—Note 12.2	antibodies, cell structure-mitochondria, fluorescence microscopy/fluorescence imaging
Molecular Probes Handbook	Lipid-mixing assays of membrane fusion—Note 13.1	cell structure-plasma membrane, fluorescent lipids, membranes, micelles
Molecular Probes Handbook	Assays of volume change, membrane fusion and membrane permeability—Note 14.3	cell structure-plasma membrane, fluorescent lipids, membranes, micelles
Molecular Probes Handbook	Antibodies for detecting membrane-surface labels—Note 13.2	antibodies, cell structure-plasma membrane, extracellular proteins
Molecular Probes Handbook	Probes for the endoplasmic reticulum and golgi apparatus—Section 12.4	antibodies, cell structure-er, cell structure-golgi, fluorescence microscopy/fluorescence imaging, fluorescent dyes
Molecular Probes Handbook	Probes for mitochondria—Section 12.2	antibodies, cell structure-mitochondria, CellLight, flow cytometer/flow cytometry, fluorescence microscopy/fluorescence imaging, fluorescent dyes
Molecular Probes Handbook	Probes for lysosomes, peroxisomes and yeast vacuoles—Section 12.3	antibodies, cell structure-lysosomes, CellLight, flow cytometer/flow cytometry, fluorescence microscopy/fluorescence imaging, fluorescent dyes
Molecular Probes Handbook	Probes for the nucleus—Section 12.5	antibodies, cell structure-nucleus, CellLight, flow cytometer/flow cytometry, fluorescence microscopy/fluorescence imaging, fluorescent dyes, membrane permeability
Molecular Probes Handbook	A diverse selection of organelle probes—Section 12.1	cell structure-er, cell structure-golgi, cell structure-lysosomes, cell structure-mitochondria, cell structure-nucleus, cell structure-plasma membrane, fluorescence microscopy/fluorescence imaging
Molecular Probes Handbook	Introduction to potentiometric probes—Section 22.1	cell structure-plasma membrane, fast-response probes, fluorescence microscopy/fluorescence imaging, fluorometer, ion channels, live-cell imaging, membrane potential, slow-response probes
Molecular Probes Handbook	Fast-response probes—Section 22.2	cell structure-plasma membrane, fast-response probes, fluorescence microscopy/fluorescence imaging, fluorometer, ion channels, live-cell imaging, membrane potential
Molecular Probes Handbook	Other nonpolar and amphiphilic probes—Section 13.5	carbocyanine dyes, cell structure-plasma membrane, DiI, fluorescence microscopy/fluorescence imaging, fluorescent lipid dyes, fluorometer
Molecular Probes Handbook	Introduction to membrane probes—Section 13.1	cell structure-plasma membrane, fast-response probes, fluorescence microscopy/fluorescence imaging, fluorometer, ion channels, live-cell imaging, membrane potential, slow-response probes
Molecular Probes Handbook	Fatty acid analogs and phospholipids—Section 13.2	cell structure-plasma membrane, fluorescence microscopy/fluorescence imaging, fluorescent fatty acid analogs, fluorescent lipid dyes, fluorometer
Molecular Probes Handbook	Dialkylcarbocyanine and dialkylaminostyryl probes—Section 13.4	carbocyanine dyes, cell structure-plasma membrane, DiI, fluorescence microscopy/fluorescence imaging, fluorescent lipid dyes, fluorometer
Molecular Probes Handbook	Probes for neurotransmitter receptors—Section 16.2	brain hormones, cell structure-plasma membrane, fluorescence microscopy/fluorescence imaging, fluorescent dyes, receptor binding
Molecular Probes Handbook	Probes for following receptor binding and phagocytosis—Section 16.1	cell structure-plasma membrane, fluorescence microscopy/fluorescence imaging, fluorescent dyes, internalization, membrane trafficking, phagocytosis, receptor binding, vesicle
Molecular Probes Handbook	Probes for tubulin and other cytoskeletal proteins—Section 11.2	cell structure-tubulin, cytoskeleton, fluorescence microscopy/fluorescence imaging, fluorescent dyes, fluorescent proteins
Molecular Probes Handbook	Probes for actin—Section 11.1	cell structure-actin, cytoskeleton, fluorescence microscopy/fluorescence imaging, fluorescent dyes, fluorescent proteins
Molecular Probes Handbook	Nucleic acid stains—Section 8.1	cell cycle, cell structure-nucleus, cell structure-plasma membrane, cell viability, DAPI, DNA binding dyes, flow cytometer/flow cytometry, fluorescence microscopy/fluorescence imaging, fluorescent dyes, fluorometer, membrane permeability, RNA binding dyes, SYTO, SYTOX
Molecular Probes Handbook	Tracers for membrane labeling—Section 14.4	cell structure-plasma membrane, cell tracking, flow cytometer/flow cytometry, fluorescence microscopy/fluorescence imaging, live-cell imaging
Protocol	TO-PRO-3 Stain	cell structure, imaging
Protocol	SYTOX Green Nucleic Acid Stain	cell structure, imaging
Protocol	SYTO 82 Nuclear Stain	cell structure, imaging
Protocol	SYTO 59 Nuclear Stain	cell structure, imaging
Protocol	NucRed Live 647 ReadyProbes Reagent	cell structure, imaging
Protocol	NucRed Dead 647 ReadyProbes Reagent for fixed cells	cell structure, imaging
Protocol	NucGreen Dead 488 ReadyProbes Reagent for fixed cells	cell structure, imaging
Protocol	NucBlue Live ReadyProbes Reagent	cell structure, imaging
Protocol	NucBlue Fixed Cell ReadyProbes Reagent	cell structure, imaging
Protocol	Hoechst 33342 for imaging	cell structure, imaging
Protocol	Hoechst 33342 for HCA instruments	cell structure, high content analysis
Protocol	HCS NuclearMask Red Stain	cell structure, high content analysis
Protocol	HCS NuclearMask Deep Red Stain	cell structure, high content analysis
Protocol	HCS NuclearMask Blue Stain	cell structure, high content analysis
Protocol	HCS CellMask Stains	cell structure, high content analysis
Protocol	DAPI for fluorescence imaging	cell structure, imaging
Protocol	DAPI for HCA instruments	cell structure, high content analysis
Protocol	ActinRed 555 ReadyProbes Reagent	cell structure, imaging
Protocol	ActinGreen 488 ReadyProbes Reagent	cell structure, imaging
Scientific poster (2009)	Cell-based assays for predictive hepatotoxicity measurements using high content imaging	Alexa Fluor, ArrayScan, cell structure-plasma membrane, Click-iT, fluorescence microscopy/fluorescence imaging, fluorescent dyes, glutathione, high content analysis, microplate reader, nucleic acid quantitation, viability
Scientific poster (2009)	High content imaging and analysis of mitotoxicity and cytotoxicity in fixed cells	cell structure-mitochondria, fluorescence microscopy/fluorescence imaging, fluorescent dyes, high content analysis, viability
Scientific poster (2010)	Autophagosomal accumulation perturbs Golgi structure without affecting other organelles: Implications for autophagosome biogenesis	Alexa Fluor, antibodies, autophagy, BacMam technology, cell structure-golgi, Click-iT, fluorescence microscopy/fluorescence imaging, fluorescent dyes, high content analysis, live-cell imaging
Scientific poster (2014)	New fluorescent probes and sensors for visualizing endocytosis, lysosomal dynamics and autophagy	autophagy, cell structure-lysosomes, endocytosis/phagocytosis, autophagy, fluorescence microscopy/fluorescence imaging, high content analysis, microplate reader
Video	Viability determination of HeLa cells using ReadyProbes Cell Viability Imaging Kit (Blue/Green) HeLa cells were loaded with NucBlue Live and NucGreen Dead (using 2 drops per ml) in complete media for 15 minutes at 37C. Staurosporine was then added to a final concentration of 1 µM and images were acquired every 30 min. for 18 hours using EVOS Auto Imaging System. All cells are stained with NucBlue Live, shown with blue nuclei. Over time an increase in the number of dead cells is observed as indicated by the appearance of green nuclei (NucGreen Dead).	cell structure-nucleus, cell viability, fluorescence microscopy/fluorescence imaging, live-cell imaging
Video	CellTracker Violet reagent and mitosis U-2 OS cells were transduced with CellLight Tubulin-GFP and Cellular Lights Actin-RFP. The following day cells were labeled with 5uM CellTracker Violet BMQC for 30 minutes at 37C in complete media and washed in fresh media. Images were taken every 5 minutes for 16 hours.	cell structure-all, cell tracking, fluorescence microscopy/fluorescence imaging, live-cell imaging
Video	Compilation of live cell imaging videos using Invitrogen fluorescent reagents This video demonstrates novel product brands from Invitrogen for live cell imaging include CellLight targeted fluorescent proteins, CellROX reagents for oxidative stress, CellEvent caspase 3/7 detection reagent, and many more fluorescent dyes and probes.	cell structure-mitochondria, CellEvent, CellLight, CellROX, fluorescence microscopy/fluorescence imaging, live-cell imaging, oxidative stress
Video	Z Stack image of HeLa cells labeled with CellLights reagents A series of images were captured on the EVOS FL Auto Cell Imaging System. Creating a Z-stack from these images allowed the observation of cellular cytoskeletal changes, which can be indicative of the loss of cell health. Methods HeLa cells grown in MatTek 6-well glass bottom culture plates were transduced with CellLights Tubulin-GFP and CellLight Mitochondria-RFP overnight at 37oC. The following day, NucBlue Live reagent (2 drops/mL) was added to the cultures. Cells were then imaged on an EVOS FL Auto Cell Imaging System with 100x oil immersion objective using the Z-stack function. The step size was set using the Nyquist formula and performed at 0.366 μm.	cell health, cell structure-all, CellLight, EVOS FL Auto Microscope, fluorescence microscopy/fluorescence imaging, fluorescent proteins, live-cell imaging
Video	Mitochondrial dynamics through cell division U2OS cells were transduced with CellLight Mito-RFP and imaged every 5 minutes for 16 hours. Extensive mitochondrial motility is seen throughout mitosis and as the cell regains it's pre mitotic shape following mitosis.	cell structure-mitochondria, CellLight, fluorescence microscopy/fluorescence imaging, live-cell imaging
Video	Exosomes—The Next Small Thing: Episode 5—Collaboration—The key to scientific success	Exosomes
Video	Exosomes—The Next Small Thing: Episode 6—Exosomes the next small thing	Exosomes
Video	Exosomes—The Next Small Thing: Episode 4—Curiosity and a passion for science	Exosomes
Video	Exosomes—The Next Small Thing: Episode 3—Exosomes in cancer research	Exosomes
Video	Exosomes—The Next Small Thing: Episode 2—The history and promise of an exosome	Exosomes
Video	Exosomes—The Next Small Thing: Episode 1—What is an exosome?	Exosomes
Webinar	Introduction to basic cytoskeleton labeling and detection The cytoskeleton is a key component of mammalian cells, providing the framework for cell migration and intracellular transport, furthermore the cytoskeleton regulates cell size and shape as well as important processes such as mitosis and endocytosis. We offer a number of solutions for researchers using fluorescent probes to study the cytoskeleton. This webinar will provide an overview of the structures that comprise the cytoskeleton and important experimental parameters. The webinar also offers a comprehensive guide to available labeling and detection technologies for cytoskeletal research as well as tips and tricks on how to best use them. These tools include those for live-cell imaging fluorescent dyes, antibodies and the BacMam gene delivery platform.	cell structure-actin, cytoskeleton, endocytosis, fluorescence microscopy/fluorescence imaging, fluorescent dyes, fluorescent proteins

For Research Use Only. Not for use in diagnostic procedures.