Prenatal software: B·R·A·H·M·S Fast Screen pre I plus for pre-eclampsia screening

Discover our modern, powerful and robust clinical prenatal screening software for pre-eclampsia in first trimester.

 

Thermo Scientific B·R·A·H·M·S Fast Screen pre I plus is a CE marked prenatal screening software. This software, designed to be used with Thermo Scientific B·R·A·H·M·S KRYPTOR Instruments and Assays, ensures convenience of data entry, risk calculation and reporting for laboratories with both low and high data throughput. 

Key features


Pre-eclampsia screening algorithms

B·R·A·H·M·S Fast Screen pre I plus comprises algorithms that are based on the Fetal Medicine Foundation UK (FMF) data and are updated with recently published correction factors.

  Pre-eclampsia
Time range
  • From 11+2 to 14+0 for biochemistry
  • From 45 mm to 84 mm for ultrasound
Biomarkers
  • PAPP-A
  • PlGF 
Physical markers
  • Mean arterial pressure (MAP)
  • Uterine arteries pulsatility index (UtA-PI)

The medians of the B·R·A·H·M·S biochemical markers free βhCG, PAPP-A and PlGF which are included in our software are extremely stable. These medians were established on over 220,000 healthy pregnancies which ensures reproducibility and robustness of the risk calculation.1,2 Therefore, a recalculation of the medians and MoMs over time is not required.


FMF first trimester test performances for pre-eclampsia

View the FMF pre-eclampsia algorithm performances below.3

  Early onset pre-eclampsia
(< week 32)
Intermediate onset pre-eclampsia 
(< week 37)
Late onset
pre-eclampsia
(≥ week 37)
Detection rate 100% 75% 43%
False positive rate 10% 10% 10%

More than just a risk calculation tool for your pre-eclampsia screening

Simple and user-friendly interface available in six languages

Available in English, German, French, Spanish, Italian, and Turkish


References

  1. Concerning free βhCG and PAPP-A medians please refer to D. Wright et al., “First-trimester combined screening for trisomy 21 at 7-14 weeks’ gestation” Ultrasound Obstet. Gynecol., vol. 36, no. 4, pp. 404–411, 2010.
  2. Concerning PlGF medians please refer to P. Pandya et al., “Maternal serum placental growth factor in prospective screening for aneuploidies at 8-13 weeks’ gestation” Fetal Diagn. Ther., vol. 31, no. 2, pp. 87–93, 2012.
  3. N. O’Gorman et al., “Accuracy of competing risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks’ gestation” Ultrasound Obstet. Gynecol., vol. 208, no. 2, pp. 109–112, Jan. 2017.

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