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Our latest research findings in drug discovery and ADME/Tox are illustrated through posters presented at conferences like SBS, AACR and others; and through peer-reviewed articles. View some of our most recent publications in the table below.
| Title | Authors | Reference |
|---|---|---|
| A Fluorescence Polarization Assay for the Muscarinic M1 G-protein Coupled Receptor | KG Huwiler, T De Rosier, BJ Hanson, KW Vogel. | Assay Drug Dev Technol. 2010 Jun;8(3):356-66. |
| Multi-Pathway Cellular Analysis of Compound Selectivity | Michael K. Hancock, Connie S. Lebakken, Jun Wang, Kun Bi | Mol Biosyst. 2010 Oct 1;6(10):1834-43. |
| ADP Detection Technologies | Lowery RG, Vogel K, Till J. | Assay Drug Dev Technol. 2010 Aug;8(4):1-2 |
| Development and Validation of a Cell-Based Assay for the Nuclear Receptor Retinoid-Related Orphan Receptor Gamma | Wilkinson J, Hallis T, Hermanson S, Bi K | Assay Drug Dev Technol. 2010 Nov 4. [Epub ahead of print] |
| Commentary: Prioritizing hits based on drug-target residence time | Vogel KW | Drug Discovery News, Sept 2010, p13 |
| Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors. | De SK, Chen V, Stebbins JL, Chen LH, Cellitti JF, Machleidt T, Barile E, Riel-Mehan M, Dahl R, Yang L, Emdadi A, Murphy R, Pellecchia M. | Bioorg Med Chem. 2010 Jan 15;18(2):590-6. |
| Covalent peroxisome proliferator-activated receptor{gamma} binding by nitro-fatty acids: Endogenous ligands act as selective modulators. | Schopfer FJ, Cole MP, Groeger AL, Chen CS, Khoo NK, Woodcock SR, Golin-Bisello F, Motanya UN, Li Y, Zhang J, Garcia-Barrio MT, Rudolph TK, Rudolph V, Bonacci G, Baker PR, Xu HE, Batthyany CI, Chen YE, Hallis TM, Freeman BA. | J Biol Chem. 2010 Apr 16;285(16):12321-33. |
| Multiplexing terbium- and europium-based TR-FRET readouts to increase kinase assay capacity. | Vogel KW, Horton R | J Biomol Screen. 2010 Sep;15(8):1008-15. |
| Differential effects of allosteric M(1) muscarinic acetylcholine receptor agonists on receptor activation, arrestin 3 recruitment, and receptor downregulation. | Davis AA, Heilman CJ, Brady AE, Miller NR, Fuerstenau-Sharp M, Hanson BJ, Lindsley CW, Conn PJ, Lah JJ, Levey AI. | ACS Chem Neurosci. 2010 Aug 18;1(8):542-551. |
| Development of a GPR23 cell-based β-lactamase reporter assay. | Lee PH, Hanson BJ. | Methods Enzymol. 2010;485:349-68 |
| Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology. | Robers MB, Loh C, Carlson CB, Yang H, Frey EA, Hermanson SB, Bi K. | Mol Biosyst. 2011 Jan 1;7(1):59-66. |
| TR-FRET Cellular Assays for Interrogating Posttranslational Modifications of Histone H3 | Thomas Machleidt, Matthew B. Robers, Spencer B. Hermanson, Jeanne M. Dudek, Kun Bi | J Biomol Screen December 2011 vol. 16 no. 10 1236-1246 |
| A Substrate-Independent TR-FRET Histone Deacetylase Inhibitor Assay | Bryan D. Marks, Stephen A. Fakhoury, William J. Frazee, Hildegarde C. Eliason, Steven M. Riddle | J Biomol Screen December 2011 vol. 16 no. 10 1247-1253 |
仅供科研使用，不可用于诊断目的。