SelectScreen Kinase Profiling Services | Thermo Fisher Scientific

Expect and receive high quality kinase profiling data in days and accelerate your lead discovery projects with our SelectScreen Kinase Profiling Services.

Labs from pharmaceutical, biotech, consumer goods, and academic institutions have utilized SelectScreen Kinase Profiling Service since their initiation in 2004.

Our kinase panel has just expanded! Over 485 kinase assays now available for screening and profiling. See the Broad Assay Panel tab below for the full listing.

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Fast data delivery

The Accelerated Data Delivery™ service returns up to 80% of your kinase profiling data to you in as little as 48 hours

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Customer Testimonials

Why do scientists trust the SelectScreen Services team?

Average data delivery time of just 5 days—so you can get data to your medicinal chemists more quickly
Access data in real-time—as soon as it is available—via our secure online portal
Broad panel of more than 485 purified kinases—to help you establish how selective a compound is to its intended targets
State-of-the-art compound management system ensures consistently high quality data is delivered for every project
Complete Lab Information Management System (LIMS) ensures project traceability and consistency

Project options

Customize your kinase profiling project to get the right data for your research.

Standard service options include:

Targets – >485 available biochemical assays
Mode – Single point concentrations and IC50 and/or EC50 determinations
Choice of ATP concentration – 10µM, 100µM, and Km [app] ATP (activity assays only)

For the kinases that are available in our activity assays, comprehensive titrations are performed against our panel of available substrates. In addition, ATP titrations are performed for each of these kinases to determine the Km[app] ATP for each target. As a result, you can choose to have your compound run at, above, or below the Km[app] ATP for each kinase within the panel that utilizes an activity assay. This flexibility allows you to identify specific types of inhibitors with various mechanisms of action.

To discuss your kinase profiling project requirements, send us an inquiry

Personalized support

From project beginning to end, you can rely on our Drug Discovery Services project management team to provide frequent project communication via a single point of contact.

Watch this two-minute video to see how our project managers and technical specialists create an exceptional experience for our customers. Submit order

Technology overview

Currently, two different assay platforms are available for profiling – activity and binding. The Z′-LYTE and Adapta kinase activity assays are used most extensively for profiling and a smaller subset of kinases may be profiled using our LanthaScreen Eu Kinase Binding Assays.

Overview of available formats

Z′-LYTE	Technology Overview	Protocol and Assay Conditions
Adapta	Technology Overview	Protocol and Assay Conditions
LanthaScreen Eu Kinase Binding Assay	Technology Overview	Protocol and Assay Conditions

A stringent validation process ensures the highest quality data possible with each data point performed in duplicate. Strict quality control protocols ensure that any assay results not meeting set specifications will be automatically repeated, this includes a control inhibitor titration (IC50) for each kinase on every plate.

To discuss your kinase profiling project requirements, send us an inquiry.

Broad assay panel

Search:

Kinase	Activity assays		Binding assay
	Z′-LYTE	Adapta	LanthaScreen
AAK1
ABL1
ABL1 E255K
ABL1 F317I
ABL1 F317L
ABL1 G250E
ABL1 H396P
ABL1 M351T
ABL1 Q252H
ABL1 T315I
ABL1 Y253F
ABL2 (Arg)
ACVR1 (ALK2)
ACVR1 (ALK2) R206H
ACVR1B (ALK4)
ACVR2A
ACVR2B
ACVRL1
ADCK3
ADRBK1 (GRK2)
ADRBK2 (GRK3)
AKT1 (PKB alpha)
AKT2 (PKB beta)
AKT3 (PKB gamma)
ALK
ALK C1156Y
ALK F1174L
ALK L1196M
ALK R1275Q
ALK T1151_L1152insT
AMPK (A1/B1/G2)
AMPK (A1/B1/G3)
AMPK (A1/B2/G1)
AMPK (A1/B2/G2)
AMPK (A1/B2/G3)
AMPK (A2/B1/G2)
AMPK (A2/B1/G3)
AMPK (A2/B2/G1)
AMPK (A2/B2/G2)
AMPK (A2/B2/G3)
AMPK A1/B1/G1
AMPK A2/B1/G1
AURKA (Aurora A)
AURKB (Aurora B)
AURKC (Aurora C)
AXL
AXL R499C
BLK
BMPR1A (ALK3)
BMPR1B (ALK6)
BMPR2
BMX
BRAF
BRAF V599E
BRSK1 (SAD1)
BRSK2
BTK
CAMK1 (CaMK1)
CAMK1D (CaMKI delta)
CAMK1G (CaMKI gamma)
CAMK2A (CaMKII alpha)
CAMK2B (CaMKII beta)
CAMK2D (CaMKII delta)
CAMK2G (CaMKII gamma)
CAMK4 (CaMKIV)
CAMKK1 (CAMKKA)
CAMKK2 (CaMKK beta)
CASK
CDC42 BPA (MRCKA)
CDC42 BPB (MRCKB)
CDC42 BPG (MRCKG)
CDC7/DBF4
CDK1/cyclin B
CDK11 (Inactive)
CDK11/cyclin C
CDK13/cyclin K
CDK14 (PFTK1)/cyclin Y
CDK16 (PCTK1)/cyclin Y
CDK17/cyclin Y
CDK18/cyclin Y
CDK2/cyclin A
CDK2/cyclin A1
CDK2/cyclin E1
CDK2/cyclin O
CDK3/cyclin E1
CDK4/cyclin D1
CDK4/cyclin D3
CDK5 (Inactive)
CDK5/p25
CDK5/p35
CDKL5
CDK6/cyclin D1
CDK7/cyclin H/MNAT1
CDK8/cyclin C
CDK9 (Inactive)
CDK9/cyclin K
CDK9/cyclin T1
CHEK1 (CHK1)
CHEK2 (CHK2)
CHUK (IKK alpha)
CLK1
CLK2
CLK3
CLK4
CSF1R (FMS)
CSK
CSNK1A1 (CK1 alpha 1)
CSNK1A1L
CSNK1D (CK1 delta)
CSNK1E (CK1 epsilon)
CSNK1E (CK1 epsilon) R178C
CSNK1G1 (CK1 gamma 1)
CSNK1G2 (CK1 gamma 2)
CSNK1G3 (CK1 gamma 3)
CSNK2A1 (CK2 alpha 1)
CSNK2A2 (CK2 alpha 2)
DAPK1
DAPK2
DAPK3 (ZIPK)
DCAMKL1 (DCLK1)
DCAMKL2 (DCK2)
DDR1
DDR2
DDR2 N456S
DDR2 T654M
DMPK
DNA-PK
DYRK1A
DYRK1B
DYRK2
DYRK3
DYRK4
EEF2K
EGFR (ErbB1)
EGFR (ErbB1) C797S
EGFR (ErbB1) d747-749 A750P
EGFR (ErbB1) G719C
EGFR (ErbB1) G719S
EGFR (ErbB1) L858R
EGFR (ErbB1) L861Q
EGFR (ErbB1) T790M
EGFR (ErbB1) T790M C797S L858R
EGFR (ErbB1) T790M L858R
EGFR d746-750
EIF2AK2
EPHA1
EPHA2
EPHA3
EPHA4
EPHA5
EPHA6
EPHA7
EPHA8
EPHB1
EPHB2
EPHB3
EPHB4
ERBB2 (HER2)
ERBB4 (HER4)
ERN1
ERN2
FER
FES (FPS)
FGFR1
FGFR1 V561M
FGFR2
FGFR2 N549H
FGFR3
FGFR3 G697C
FGFR3 K650E
FGFR3 K650M
FGFR3 V555M
FGFR4
FGR
FLT4 (VEGFR3)
FLT1 (VEGFR1)
FLT3
FLT3 D835Y
FLT3 ITD
FRAP1 (mTOR)
FRK (PTK5)
FYN
FYN A
GAK
GRK1
GRK4
GRK5
GRK6
GRK7
GSG2 (Haspin)
GSK3A (GSK3 alpha)
GSK3B (GSK3 beta)
HCK
HIPK1 (Myak)
HIPK2
HIPK3 (YAK1)
HIPK4
HUNK
ICK
IGF1R
IKBKB (IKK beta)
IKBKE (IKK epsilon)
INSR
INSRR (IRR)
IRAK1
IRAK3
IRAK4
ITK
JAK1
JAK2
JAK2 JH1 JH2
JAK2 JH1 JH2 V617F
JAK3
KDR (VEGFR2)
KIT
KIT A829P
KIT D816H
KIT D816V
KIT D820E
KIT N822K
KIT T670E
KIT T670I
KIT V559D
KIT V559D T670I
KIT V559D V654A
KIT V560G
KIT V654A
KIT Y823D
KSR2
LATS1
LATS2
LCK
LIMK1
LIMK2
LRRK2
LRRK2 FL
LRRK2 G2019S
LRRK2 G2019S FL
LRRK2 I2020T
LRRK2 R1441C
LTK (TYK1)
LYN A
LYN B
MAP2K1 (MEK1 )
MAP2K1 (MEK1) S218D S222D
MAP2K2 (MEK2)
MAP2K4 (MEK4)
MAP2K5 (MEK5)
MAP2K6 (MKK6)
MAP2K6 (MKK6) S207E T211E
MAP3K10 (MLK2)
MAP3K11 (MLK3)
MAP3K14 (NIK)
MAP3K19 (YSK4)
MAP3K2 (MEKK2)
MAP3K3 (MEKK3)
MAP3K5 (ASK1)
MAPK7 (ERK5)
MAP3K7/MAP3K7IP1 (TAK1-TAB1)
MAP3K8 (COT)
MAP3K9 (MLK1)
MAP4K1 (HPK1)
MAP4K2 (GCK)
MAP4K3 (GLK)
MAP4K4 (HGK)
MAP4K5 (KHS1)
MAPK1 (ERK2)
MAPK10 (JNK3)
MAPK11 (p38 beta)
MAPK12 (p38 gamma)
MAPK13 (p38 delta)
MAPK14 (p38 alpha)
MAPK14 (p38 alpha) Direct
MAPK15 (ERK7)
MAPK3 (ERK1)
MAPK8 (JNK1 )
MAPK9 (JNK2)
MAPKAPK2
MAPKAPK3
MAPKAPK5 (PRAK)
MARK1 (MARK)
MARK2
MARK3
MARK4
MASTL
MATK (HYL)
MELK
MERTK (cMER)
MERTK (cMER) A708S
MET (cMet)
MET (cMET) Y1235D
MET D1228H
MET M1250T
MINK1
MKNK1 (MNK1)
MKNK2 (MNK2)
MLCK (MLCK2)
MLK4
MST1R (RON)
MST4
MUSK
MYLK (MLCK)
MYLK2 (skMLCK)
MYLK4
MYO3A (MYO3 alpha)
MYO3B (MYO3 beta)
NEK1
NEK2
NEK4
NEK6
NEK7
NEK8
NEK9
NIM1K
NLK
NTRK1 (TRKA)
NTRK2 (TRKB)
NTRK3 (TRKC)
NUAK1 (ARK5)
NUAK2
PAK1
PAK2 (PAK65)
PAK3
PAK4
PAK6
PAK7 (KIAA1264)
PASK
PDGFRA (PDGFR alpha)
PDGFRA D842V
PDGFRA T674I
PDGFRA V561D
PDGFRB (PDGFR beta)
PDK1
PDK1 Direct
PEAK1
PHKG1
PHKG2
PI4K2A (PI4K2 alpha)
PI4K2B (PI4K2 beta)
PI4KA
PI4KB (PI4K beta)
PIK3C2A (PI3K-C2 alpha)
PIK3C2B (PI3K-C2 beta)
PIK3C2G (PI3K-C2 gamma)
PIK3C3 (hVPS34)
PIK3CA E542K/PIK3R1 (p110 alpha E542K/p85 alpha)
PIK3CA E545K/PIK3R1 (p110 alpha E545K/p85 alpha)
PIK3CA/PIK3R1 (p110 alpha/p85 alpha)
PIK3CA/PIK3R3 (p110 alpha /p55 gamma)
PIK3CB/PIK3R1 (p110 beta/p85 alpha)
PIK3CB/PIK3R2 (p110 beta/p85 beta)
PIK3CD/PIK3R1 (p110 delta/p85 alpha)
PIK3CG (p110 gamma)
PIM1
PIM2
PIM3
PIP4K2A
PIP5K1A
PIP5K1B
PIP5K1C
PKN1 (PRK1)
PKN2
PLK1
PLK2
PLK3
PLK4
PKMYT1
PRKACA (PKA)
PRKACB (PRKAC beta)
PRKACG (PRKAC gamma)
PRKCA (PKC alpha)
PRKCB1 (PKC beta I)
PRKCB2 (PKC beta II)
PRKCD (PKC delta)
PRKCE (PKC epsilon)
PRKCG (PKC gamma)
PRKCH (PKC eta)
PRKCI (PKC iota)
PRKCN (PKD3)
PRKCQ (PKC theta)
PRKCZ (PKC zeta)
PRKD1 (PKC mu)
PRKD2 (PKD2)
PRKG1
PRKG2 (PKG2)
PRKX
PTK2 (FAK)
PTK2B (FAK2)
PTK6 (Brk)
RAF1 (cRAF) Y340D Y341D
RET
RET A883F
RET G691S
RET M918T
RET S891A
RET V804E
RET V804L
RET V804M
RET Y791F
RIPK2
RIPK3
ROCK1
ROCK2
ROS1
RPS6KA1 (RSK1)
RPS6KA2 (RSK3)
RPS6KA3 (RSK2)
RPS6KA4 (MSK2)
RPS6KA5 (MSK1)
RPS6KA6 (RSK4)
RPS6KB1 (p70S6K)
RPS6KB2 (p70S6Kb)
SBK1
SGK (SGK1)
SGK2
SGKL (SGK3)
SIK1
SIK3
SLK
SNF1LK2
SPHK1
SPHK2
SRC
SRC N1
SRMS (Srm)
SRPK1
SRPK2
STK16 (PKL12)
STK17A (DRAK1)
STK17B (DRAK2)
STK22B (TSSK2)
STK22D (TSSK1)
STK23 (MSSK1)
STK24 (MST3)
STK25 (YSK1)
STK3 (MST2 )
STK32B (YANK2)
STK32C (YANK3)
STK33
STK38 (NDR)
STK38L (NDR2)
STK39 (STLK3)
STK4 (MST1)
SYK
TAOK1
TAOK2 (TAO1)
TAOK3 (JIK)
TBK1
TEC
TEK (TIE2)
TEK (TIE2) R849W
TEK (TIE2) Y1108F
TEK (TIE2) Y897S
TESK1
TGFBR1 (ALK5)
TGFBR2
TLK1
TLK2
TNIK
TNK1
TNK2 (ACK)
TTK
TXK
TYK2
TYRO3 (RSE)
ULK1
ULK2
ULK3
VRK2
WEE1
WNK1
WNK2
WNK3
YES1
ZAK
ZAP70

Kinase biology tools

With the broadest collections of assays, high-throughput screening and profiling services, and access to customized assays and tools designed to meet your specifications, your lab can choose the right kinase biology tools and services for your exact stage of research.

Project Options