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Succinates |
Succinates are used for the derivatization of controlled pore glass, polystyrene, or other supports for solid-phase oligonucleotide synthesis. Our DNA succinates are formulated as triethylammonium (TEA) salts with standard base protection. They provide the high quality and stringent manufacturing controls required for bench and therapeutic applications.
DNA succinates
Thermo Scientific Bz dA, Bz dC, iBu dG, and T succinates are available as TEA salts with standard base protection.
Technical specifications
| Bz dA succinate | Bz dC succinate | iBu dG succinate | T succinate | |
|---|---|---|---|---|
| Chemical structure (Full size images in accordion below) |  |  |  |  |
| Cat. No. | 27-0030 | 27-0032 | 27-0034 | 27-0036 |
| Chemical name | 5′-O-(4,4'-dimethoxytrityl)-N6-(benzoyl)-2′-deoxyadenosine-3′-succinate, triethylammonium salt | 5′-O-(4,4'-dimethoxytrityl)-N4-(benzoyl)-2′-deoxycytidine-3′-succinate, triethylammonium salt | 5′-O-(4,4'-dimethoxytrityl)-N2-(isobutyryl)-2′-deoxyguanosine-3′-succinate, triethylammonium salt | 5′-O-(4,4'-dimethoxytrityl)-thymidine-3′-succinate, triethylammonium salt |
| Formula | C48H54N6O9 | C47H54N4O10 | C45H56N6O10 | C43H51N3O10 |
| Molecular weight | 859 g/mol | 835 g/mol | 841 g/mol | 746 g/mol |
| HPLC purity | ≥98.0% | ≥98.0% | ≥95.0% | ≥98.0% |
| Shipping / storage condition | Ambient / –20°C | |||
| Request quote | ||||
Quality manufacturing and documentation
Processes are monitored from material procurement through final QC and product release for batch-to-batch reproducibility. Purity of each product lot is assessed by HPLC, MS, and NMR. Our expertise in manufacturing processes help minimize levels of impurities that could be incorporated into the oligonucleotide during synthesis and result in the accumulation of by-products.
Quick tour of our manufacturing facility for phosphoramidites
Our phosphoramidites are manufactured in a facility with ISO 9001:2015–certified quality management system and analytical documentation support at the facility in Milwaukee (WI, USA). We have been customizing and scaling up high-quality amidites for oligonucleotide synthesis, for over 40 years.
Resources
Technical Spotlights
Custom Services and Quotation
Speak with a technical specialist about support available for the oligonucleotide manufacturing process development of your unique projects.
Phosphoramidite Learning Resource
Access webinars, videos, articles, and more to optimize your success in oligonucleotide synthesis for diagnostic and therapeutic manufacturing process development.
mRNA Production Learning Library
Browse the educational assets related to raw materials selection, process development using in vitro transcription, scale-up synthesis, and the latest trends in mRNA production.
For Research Use Only. Not for use in diagnostic procedures.
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