Mass Spectrometry for Clinical Translational Research

Understanding disease states for targeted therapeutics

Thermo Scientific LC-MS systems deliver the analytical specificity, sensitivity and dynamic range you need for the analysis of complex biological samples such as plasma, serum, whole blood, urine, sputum, cerebrospinal fluid (CSF), and oral fluid. Our solutions can help you conduct studies in fields from protein biomarker discovery and validation (metabolites and lipids) to research on cancer, endocrine functions, infectious diseases, Alzheimer's, and more.

Research-to-routine workflow

The research-to-routine workflow is dependent on two key attributes for success. The first is compound characterization during the research phase. The second is the ability to automate the creation of a user-defined target list that the instrument can use during targeted data acquisition. Thermo Fisher Scientific offers clinical translational research solutions that provide comprehensive compound identification and characterization with simple method transfer to select compounds of interest and create a targeted panel for proteomics, metabolomics and lipidomics analyses.

Bottom-up and top-down analysis can identify more proteins and/or expression levels of known targets in biological systems than ever before using leading technology and advances in mass accuracy, resolution, speed, and fragmentation techniques.

Proteomics workflow

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Learn more about clinical translational research proteomics on our Translational Proteomics page

The goals of metabolomics are to determine the metabolomic profiles of phenotypic diseases and healthy states, involving a complex set of genomic and proteomic changes. Analysis of the metabolites is improved with a mass spectrometry with high sensitivity and being capable of measuring a wide dynamic range of analytes ranging from very hydrophilic to hydrophobic.

Metabolomics workflow

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Learn more about clinical translational research for metabolomics on the Planet Orbitrap Untargeted Metabolomics page.

Lipidomics is a systems-based study of all lipid molecules within a biological system, tissue, fluid or cell. In order to detect and resolve as many isobaric and isomeric species from the biological lipid extracts, it is critical that the LC-MSⁿ platform offers high resolving power on both HPLC separation and MS detection.