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Automated Nucleic Acid Extraction Kits |
Automated nucleic acid extraction kits typically include appropriately filled buffers and reagents in vials, cartridges, or plates. The kits are designed to be paired with liquid handlers and purification systems that automate the extraction of DNA and RNA from a variety of biological samples.
What are some of the advantages of magnetic beads over other DNA purification methods?
- Exceptional binding capacity by thorough exposure to the target during mixing and washing steps
- Less clogging due to mobile dispersion and regular density
- Improved elution even at small volumes as a low as 1 mL
- Greater sample range across samples that have different viscosities
- Versatility from low to high throughput applications and protocols
Quickly find the right kits and reagents for your nucleic acid extraction using the Sample Purification System Kit, Reagent, and Protocol Selection Tool.
Applications for magnetic bead purification
Purification by sample type
Magnetic bead DNA extraction
The MagMAX DNA Multi-Sample Ultra 2.0 Kit is an automatable magnetic bead-based sample preparation technology for the isolation of genomic DNA (gDNA) from 50 µL to 2 mL of whole blood, saliva, buffy coat, and buccal swabs.
The MagMAX DNA Multi-Sample Ultra Kit is optimized to isolate genomic DNA (gDNA) from a variety of samples, such as whole blood, buccal cells, saliva, urine, blood cards, mouth rinse, and tissue.
Explore: MagMAX DNA Multi-Sample Ultra Kit
DNA Multi Sample Ultra 2.0 Kit
Expand your possibilities—introducing additional sample purification capabilities. Isolate genomic DNA from bone marrow samples and 10 mL of whole blood on KingFisher instruments.
Magnetic bead RNA extraction
Magnetic bead-based methods of RNA extraction are comparable to other methods, with the added benefits of reduced risk of cross-contamination during sample processing, the ability to isolate RNA directly from a variety of crude sample types, and our magnetic beads are non-porous, removing time-consuming incubation steps.
Isolate total RNA, as well as small RNAs such as microRNA (miRNA), from serum/plasma, whole blood, tissue, cell culture, and urine using a phenol-free extraction.
Cell-free DNA (cfDNA)
Cell-free DNA (cfDNA) can be extracted from multiple sample types using MagMAX Cell-Free Total Nucleic Acid Isolation Kit and MagMAX Cell-Free DNA Isolation Kit. These kits utilize magnetic bead-based technology that helps ensure reproducible recovery of high-quality nucleic acid. This sample preparation step is suitable for a broad range of applications, including real-time PCR, digital PCR, and next-generation sequencing.
Isolate and analyze circulating cell-free total nucleic acid (cfTNA) from plasma and other cell-free samples as a non-invasive method to analyze and monitor targets associated with certain disease states such as cancer.
Isolate and analyze circulating cfDNA from plasma, serum, or urine as a non-invasive approach to analyze and monitor targets associated with certain disease states such as cancer.
Explore: MagMAX Cell-Free DNA Isolation Kit
Cell-Free DNA Isolation Kit
Expand your possibilities—introducing additional sample purification capabilities. Isolate cell-free DNA from saliva and 10 mL of urine on KingFisher instruments.
Formaldehyde-fixed paraffin-embedded (FFPE) tissue sample extraction
Formaldehyde-fixed paraffin-embedded (FFPE) and paraformaldehyde-fixed tissue samples can be sensitive to work with and require attention to detail for proper nucleic acid isolation. Researchers seeking reliable nucleic acid isolation from FFPE samples can achieve this using the MagMAX FFPE DNA/RNA Ultra Kit. DNA and RNA are sequentially extracted from the same FFPE sample in a single workflow, enabling versatile sample analysis. Samples can also be processed either manually or in an automated system using open robotics to process up to 96 samples simultaneously.
Recover sequential isolations of DNA and RNA from the same formaldehyde- or paraformaldehyde-fixed paraffin-embedded (FFPE) tissue sample.
Learn more: MagMAX FFPE DNA/RNA Ultra Kit
Viral and pathogen nucleic acid isolation
MagMAX Viral/Pathogen kits and reagents use magnetic bead-based technology to purify high-quality nucleic acid from a range of research sample types both manually and through automation. To help save time and increase reproducibility, combine with KingFisher instruments for automated purification. Our kits are recommended for viral nucleic acid isolation for SARS-CoV-2 and other infectious disease pathogens.
Recover nucleic acid from viral, bacterial (gram positive and gram negative), fungal, and parasitic pathogens from a variety of biological sample types such as swabs in transport media, saliva, stool, urine, plasma and serum.
Learn More:MagMAX Prime Viral/Pathogen NA Isolation Kit
Recover high quality nucleic acids from virus and gram-negative bacteria in samples such as blood, swabs, urine, and viral transport media (VTM).
Learn more: MagMAX Viral/Pathogen Nucleic Acid Isolation Kit (MVP I)
Recover high quality nucleic acids from virus and gram-negative bacteria in samples such as blood, swabs, urine, and viral transport media (VTM) in bulk prep format.
Learn more: MagMAX Viral/Pathogen Nucleic Acid Isolation Kit (MVP II)
Recover nucleic acid from viral particles, gram negative bacteria; as well as from the tough pathogens, such as gram-positive bacteria, yeast, and fungi with this comprehensive kit.
Learn more: MagMAX Viral/Pathogen Ultra Nucleic Acid Isolation Kit
The following products are recommended for research based viral nucleic acid isolation for SARS-CoV-2 and other infectious disease pathogens. To learn about the differences between the kits, please see Frequently Asked Questions.
For more information on ordering MagMAX Viral/Pathogen II Nucleic Acid Isolation kit (A48383R) please contact customer service.
MagMAX magnetic bead purification by sample type
Microbial DNA isolation
Microbial DNA can be isolated and enriched to help researchers better understand how the microbiome influences human health. It is of utmost importance that the nucleic acids recovered accurately reflect the representation of the diverse microbes in the sample community. Our products offer high- and low-throughput purification of high-quality nucleic acids from a wide variety of sample types, including challenging samples such as stool and soil. Recovered nucleic acids are compatible with a broad range of applications, including microarrays, real-time PCR, and next-generation sequencing.
Enables efficient, high- and low-throughput nucleic acid extraction with unique reagents specifically developed for microbiome research from stool, swabs, transport media, culture media, urine, saliva, and soil samples.
Learn more: MagMAX Microbiome Ultra Nucleic Acid Isolation Kit
Recover mid to high throughput nucleic acid for gastrointestinal testing from biological samples such as stool, urine and saliva.
Learn More:MagMAX Prime Viral/Pathogen NA Isolation Kit
Wastewater testing and surveillance for infectious agents
Wastewater surveillance has recently gained significant attention as a useful tool for monitoring the regional spread of infectious disease, including the novel coronavirus and other airborne pathogens. MagMAX Wastewater Ultra Nucleic Acid Isolation Kits offer a whole host of advantages over traditional wastewater surveillance methods. They are easy to use, and you can isolate nucleic acids from concentrated wastewater in as little as 45 minutes. Our viral enrichment protocol using magnetic beads offers an efficient concentration and nucleic acid isolation.
Explore: Wastewater surveillance
High-throughput recovery of high-quality nucleic acids from wastewater samples compatible with a broad range of applications, including real-time PCR and next-generation sequencing.
High-throughput virus enrichment and nucleic acid extraction from wastewater samples compatible with a broad range of applications, including real-time PCR and next-generation sequencing.
Explore: MagMAX Wastewater Ultra Nucleic Acid Isolation Kit with Virus Enrichment
DNA extraction from saliva
Saliva can be collected non-invasively and is a common source of DNA for research. Without compromising yield and purity, the MagMAX Saliva gDNA Isolation Kit uses a single step to minimize the time and effort typically required by other methods which may use multiple laborious sample processing steps. Process a broad range of sample volume inputs simultaneously without sample normalization or reagent volume adjustments for hassle-free sample prep.
Isolate genomic DNA from fresh and stabilized saliva ideal for applications such as qPCR, next-generation sequencing, and microarray analysis.
Explore: MagMAX Saliva gDNA Isolation Kit
Guide for saliva collection and testing
Learn more about saliva-based research in our “How-To” Guide for Saliva Collection and Testing. This complex biofluid plays a critical role in human physiology and disease pathophysiology.
HIV-1 RNA isolation from dried blood spots
HIV-1 RNA can be isolated now from dried blood spots (DBS), a sample type that requires no specialized equipment for transport and can be shipped at ambient temperatures. DBS sampling is a cost-effective solution, with easy transportation protocols, that can extend the reach of global health and surveillance in remote populations. The MagMAX Viral/Pathogen Nucleic Acid Isolation Kit for HIV-1 Dried Blood Spots isolates and purifies nucleic acid from dried blood spots (DBS) or plasma. The MagMAX Viral/Pathogen Nucleic Acid Isolation Kit for HIV-1 Dried Blood Spots is compatible with KingFisher automated purification systems and downstream assays such as the HIV-1 Genotyping Kit with Integrase.
Recover high-quality HIV-1 viral RNA from dried blood spots (DBS) and plasma for HIV-1 drug resistance testing compatible with downstream applications such as RT-PCR and Sanger sequencing.
Explore: MagMAX Viral/Pathogen Nucleic Acid Isolation Kit for HIV-1 Dried Blood Spots
Genotyping workflow used to detect HIV drug resistance
Click image to enlarge
Steps in a typical genotyping workflow include specimen processing, RNA extraction, RT-PCR, nested PCR, confirmation, purification, cycle sequencing, sequencing clean-up, sequence detection, and data analysis.
Plant cell RNA and DNA extraction
Steps to extract DNA and RNA from plant samples includes the following: Disrupt the tissue and homogenize the plant sample, bind nucleic acid with target magnetic beads, wash and elute sample to purify DNA using a magnetic particle processing instrument or manually using microcentrifuge tubes.
Challenges of extracting DNA and RNA from plants can be difficult and require kits specifically designed to mitigate carbohydrates, phenolics, and other compounds found in plant tissues. Cell walls can be difficult to disrupt, and lysates often contain inhibiting compounds such as tannins, phenolics, and complex polysaccharides which may hinder DNA quality, affecting downstream reactions.
For automated high-throughput extraction or manual purification, the MagMAX Plant DNA Isolation Kit is designed to reduce these challenges and effectively extract DNA from a wide variety of plant species. The kit uses MagMAX magnetic bead technology and eliminates the need for phenol/chloroform extraction or alcohol precipitation. The procedures are optimized for the isolation of DNA from 10–100 mg plant samples. DNA yields vary between different species and tissues depending on genome size, ploidy, cell number, age of tissue sample, and storage conditions.
Automated high-throughput or manual purification of DNA from a wide variety of plant species for use in a wide range of downstream applications such as PCR, qPCR, or next-generation sequencing.
Explore: MagMAX Plant DNA Isolation Kit
Automated high-throughput or manual purification of total RNA from wide variety of plant species and tissue types for use in a wide range of downstream applications, such as RT-PCR, RT-qPCR, and other enzymatic reactions.
Explore: MagMAX Plant RNA Isolation Kit
Microbial DNA isolation
Microbial DNA can be isolated and enriched to help researchers better understand how the microbiome influences human health. It is of utmost importance that the nucleic acids recovered accurately reflect the representation of the diverse microbes in the sample community. Our products offer high- and low-throughput purification of high-quality nucleic acids from a wide variety of sample types, including challenging samples such as stool and soil. Recovered nucleic acids are compatible with a broad range of applications, including microarrays, real-time PCR, and next-generation sequencing.
Enables efficient, high- and low-throughput nucleic acid extraction with unique reagents specifically developed for microbiome research from stool, swabs, transport media, culture media, urine, saliva, and soil samples.
Learn more: MagMAX Microbiome Ultra Nucleic Acid Isolation Kit
Recover mid to high throughput nucleic acid for gastrointestinal testing from biological samples such as stool, urine and saliva.
Learn More:MagMAX Prime Viral/Pathogen NA Isolation Kit
Wastewater testing and surveillance for infectious agents
Wastewater surveillance has recently gained significant attention as a useful tool for monitoring the regional spread of infectious disease, including the novel coronavirus and other airborne pathogens. MagMAX Wastewater Ultra Nucleic Acid Isolation Kits offer a whole host of advantages over traditional wastewater surveillance methods. They are easy to use, and you can isolate nucleic acids from concentrated wastewater in as little as 45 minutes. Our viral enrichment protocol using magnetic beads offers an efficient concentration and nucleic acid isolation.
Explore: Wastewater surveillance
High-throughput recovery of high-quality nucleic acids from wastewater samples compatible with a broad range of applications, including real-time PCR and next-generation sequencing.
High-throughput virus enrichment and nucleic acid extraction from wastewater samples compatible with a broad range of applications, including real-time PCR and next-generation sequencing.
Explore: MagMAX Wastewater Ultra Nucleic Acid Isolation Kit with Virus Enrichment
DNA extraction from saliva
Saliva can be collected non-invasively and is a common source of DNA for research. Without compromising yield and purity, the MagMAX Saliva gDNA Isolation Kit uses a single step to minimize the time and effort typically required by other methods which may use multiple laborious sample processing steps. Process a broad range of sample volume inputs simultaneously without sample normalization or reagent volume adjustments for hassle-free sample prep.
Isolate genomic DNA from fresh and stabilized saliva ideal for applications such as qPCR, next-generation sequencing, and microarray analysis.
Explore: MagMAX Saliva gDNA Isolation Kit
Guide for saliva collection and testing
Learn more about saliva-based research in our “How-To” Guide for Saliva Collection and Testing. This complex biofluid plays a critical role in human physiology and disease pathophysiology.
HIV-1 RNA isolation from dried blood spots
HIV-1 RNA can be isolated now from dried blood spots (DBS), a sample type that requires no specialized equipment for transport and can be shipped at ambient temperatures. DBS sampling is a cost-effective solution, with easy transportation protocols, that can extend the reach of global health and surveillance in remote populations. The MagMAX Viral/Pathogen Nucleic Acid Isolation Kit for HIV-1 Dried Blood Spots isolates and purifies nucleic acid from dried blood spots (DBS) or plasma. The MagMAX Viral/Pathogen Nucleic Acid Isolation Kit for HIV-1 Dried Blood Spots is compatible with KingFisher automated purification systems and downstream assays such as the HIV-1 Genotyping Kit with Integrase.
Recover high-quality HIV-1 viral RNA from dried blood spots (DBS) and plasma for HIV-1 drug resistance testing compatible with downstream applications such as RT-PCR and Sanger sequencing.
Explore: MagMAX Viral/Pathogen Nucleic Acid Isolation Kit for HIV-1 Dried Blood Spots
Genotyping workflow used to detect HIV drug resistance
Click image to enlarge
Steps in a typical genotyping workflow include specimen processing, RNA extraction, RT-PCR, nested PCR, confirmation, purification, cycle sequencing, sequencing clean-up, sequence detection, and data analysis.
Plant cell RNA and DNA extraction
Steps to extract DNA and RNA from plant samples includes the following: Disrupt the tissue and homogenize the plant sample, bind nucleic acid with target magnetic beads, wash and elute sample to purify DNA using a magnetic particle processing instrument or manually using microcentrifuge tubes.
Challenges of extracting DNA and RNA from plants can be difficult and require kits specifically designed to mitigate carbohydrates, phenolics, and other compounds found in plant tissues. Cell walls can be difficult to disrupt, and lysates often contain inhibiting compounds such as tannins, phenolics, and complex polysaccharides which may hinder DNA quality, affecting downstream reactions.
For automated high-throughput extraction or manual purification, the MagMAX Plant DNA Isolation Kit is designed to reduce these challenges and effectively extract DNA from a wide variety of plant species. The kit uses MagMAX magnetic bead technology and eliminates the need for phenol/chloroform extraction or alcohol precipitation. The procedures are optimized for the isolation of DNA from 10–100 mg plant samples. DNA yields vary between different species and tissues depending on genome size, ploidy, cell number, age of tissue sample, and storage conditions.
Automated high-throughput or manual purification of DNA from a wide variety of plant species for use in a wide range of downstream applications such as PCR, qPCR, or next-generation sequencing.
Explore: MagMAX Plant DNA Isolation Kit
Automated high-throughput or manual purification of total RNA from wide variety of plant species and tissue types for use in a wide range of downstream applications, such as RT-PCR, RT-qPCR, and other enzymatic reactions.
Explore: MagMAX Plant RNA Isolation Kit
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Automate MagMAX Kits using KingFisher instruments
Benefits of KingFisher instruments include
- Various throughputs—Process 6–96 samples per run depending on the instrument model
- Interchangeable formats—Process a wide range of input volumes
- Protocol customization—Easily edit, modify, or create new protocols
- Optimized reagents—Compatible with multiple magnetic-bead reagents
Explore: KingFisher instruments
Download: Validated software automation scripts for KingFisher purification instruments
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