Product References
Microbially-Induced Exosomes from Dendritic Cells Promote Paracrine Immune Senescence: Novel Mechanism of Bone Degenerative Disease in Mice.
Aging and disease
Elsayed R,Elashiry M,Liu Y,Morandini AC,El-Awady A,Elashiry MM,Hamrick M,Cutler CW
17-0114-82 was used in Flow cytometry/Cell sorting to conclude that immune senescence, compounded by advanced age, and accelerated by oral dysbiosis and its induced SASP exosomes, plays a pivotal role in the pathophysiology of experimental periodontitis.
Wed Feb 01 00:00:00 EST 2023
Monocytes reprogrammed by tumor microparticle vaccine inhibit tumorigenesis and tumor development.
Cancer nanotechnology
Sun W,Dai L,Cao Y,Pan P,Zhi L,Wang X,Yuan X,Gao Z,Guo S,Liu G,Yin J,Xie L,Wang L,Wang Y,Li W,Li H,Jia Y
17-0114-82 was used in Flow cytometry/Cell sorting to provide novel vaccination strategy for the development of tumor vaccines and facilitate the application of T-MPs for clinic oncotherapy.
Tue Apr 25 00:00:00 EDT 2023
Enhanced uptake and anti-maturation effect of celastrol-loaded mannosylated liposomes on dendritic cells for psoriasis treatment.
Acta pharmaceutica Sinica. B
Xi L,Lin Z,Qiu F,Chen S,Li P,Chen X,Wang Z,Zheng Y
17-0114-82 was used in Flow Cytometry to investigate load celastrol, an anti-inflammatory ingredient isolated from Chinese herbs, on mannosylated liposomes to enhance dendrite cells uptake as well as to induce tolerance in an imiquimod-induced psoriasis-like mouse model.
Sat Jan 01 00:00:00 EST 2022
WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues.
Developmental cell
Gaertner F,Reis-Rodrigues P,de Vries I,Hons M,Aguilera J,Riedl M,Leithner A,Tasciyan S,Kopf A,Merrin J,Zheden V,Kaufmann WA,Hauschild R,Sixt M
17-0114-82 was used in Flow Cytometry to show that the actin cortex of leukocytes is mechanoresponsive and that this responsiveness requires neither force sensing via the nucleus nor adhesive interactions with a substrate.
Mon Jan 10 00:00:00 EST 2022
Nanoplatform Self-Assembly from Small Molecules of Porphyrin Derivatives for NIR-II Fluorescence Imaging Guided Photothermal-Immunotherapy.
Advanced healthcare materials
Cao Y,Wei D,Yang L,Luo Z,Yu P,Li H,Zhang C,Liu X,Wu F,Wu M,Zeng Y
17-0114-82 was used in Flow Cytometry to provide a promising therapeutic paradigm with porphyrin derivatives nano-assembly as phototheranostic agents for the treatment of aggressive tumors with high efficiency.
Wed Jun 01 00:00:00 EDT 2022
Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14.
eLife
Tomasek K,Leithner A,Glatzova I,Lukesch MS,Guet CC,Sixt M
17-0114-82 was used in flow cytometry to identify CD14, the major co-receptor for lipopolysaccharide detection, on mouse dendritic cells (DCs) as a binding partner of FimH, the protein located at the tip of the type 1 pilus of Escherichia coli.
Tue Jul 26 00:00:00 EDT 2022
Ferroptosis Inducer Improves the Efficacy of Oncolytic Virus-Mediated Cancer Immunotherapy.
Biomedicines
Liu W,Chen H,Zhu Z,Liu Z,Ma C,Lee YJ,Bartlett DL,Guo ZS
17-0114-82 was used in Flow cytometry/Cell sorting to demonstrate that erastin can exert cytotoxicity on cancer cells via ferroptosis, but has little effect on immune activity by itself.
Wed Jun 15 00:00:00 EDT 2022
IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology
Auyeung VC,Downey MS,Thamsen M,Wenger TA,Backes BJ,Sheppard D,Papa FR
17-0114-82 was used in Flow cytometry/Cell sorting to show that the bifunctional kinase/RNase-IRE1α-a central mediator of the unfolded protein response (UPR) to endoplasmic reticulum (ER) stress is a critical promoter of DATP abundance and function.
Fri Apr 01 00:00:00 EDT 2022
NLRP6 Inflammasome Modulates Disease Progression in a Chronic-Plus-Binge Mouse Model of Alcoholic Liver Disease.
Cells
Mainz RE,Albers S,Haque M,Sonntag R,Treichel NS,Clavel T,Latz E,Schneider KM,Trautwein C,Otto T
17-0114-82 was used in Flow cytometry/Cell sorting to evaluate a novel mouse model for ALD characterized by 8-week chronic-plus-binge ethanol administration and to investigate the role of NLRP6 inflammasome for intestinal homeostasis and ALD progression using Nlrp6-/- mice.
Thu Jan 06 00:00:00 EST 2022
Lysosomal acid lipase, CSF1R, and PD-L1 determine functions of CD11c+ myeloid-derived suppressor cells.
JCI insight
Zhao T,Liu S,Ding X,Johnson EM,Hanna NH,Singh K,Sen CK,Wan J,Du H,Yan C
17-0114-82 was used in Flow cytometry/Cell sorting to investigate if CD11c+ cells switched their functions to immune suppression and tumor growth stimulation through CSF1R/PD-L1 upregulation and metabolic reprogramming.
Thu Sep 08 00:00:00 EDT 2022
Erythropoietin directly remodels the clonal composition of murine hematopoietic multipotent progenitor cells.
eLife
Eisele AS,Cosgrove J,Magniez A,Tubeuf E,Tenreira Bento S,Conrad C,Cayrac F,Tak T,Lyne AM,Urbanus J,Perié L
17-0114-82 was used in flow cytometry to show that EPO does act directly on MPP independent of the niche and modulates fate by remodeling the clonal composition of the MPP pool.
Tue Feb 15 00:00:00 EST 2022
Ultrasound combined with nanobubbles promotes systemic anticancer immunity and augments anti-PD1 efficacy.
Journal for immunotherapy of cancer
Hu J,He J,Wang Y,Zhao Y,Fang K,Dong Y,Chen Y,Zhang Y,Zhang C,Wang H,Tan J,Wang J,Zi R,Liu C,Liang H,Guo Y,Ou J
17-0114-82 was used in Flow Cytometry to provide a promising strategy for sensitizing poorly immunogenic solid tumors to immunotherapy in the clinic.
Tue Mar 01 00:00:00 EST 2022
Self-assembled traditional Chinese nanomedicine modulating tumor immunosuppressive microenvironment for colorectal cancer immunotherapy.
Theranostics
Mao Q,Min J,Zeng R,Liu H,Li H,Zhang C,Zheng A,Lin J,Liu X,Wu M
17-0114-82 was used in Flow cytometry/Cell sorting to provides a promising self-assembled traditional Chinese nanomedicine to improve immunotherapy for colorectal cancer (CRC), which might be applicable for future clinical translation.
Thu Sep 29 00:00:00 EDT 2022
TLR4 pathway impairs synaptic number and cerebrovascular functions through astrocyte activation following traumatic brain injury.
British journal of pharmacology
Rosa JM,Farré-Alins V,Ortega MC,Navarrete M,Lopez-Rodriguez AB,Palomino-Antolín A,Fernández-López E,Vila-Del Sol V,Decouty C,Narros-Fernández P,Clemente D,Egea J
17-0114-82 was used in Flow Cytometry to demonstrate that TLR4-mediated signalling, most probably through microglia and/or infiltrated monocyte-astrocyte communication, plays a crucial role in the TBI pathophysiology and that its inhibition prevents synaptic loss and BBB damage accelerating tissue recovery/repair, which might represent a therapeutic potential in CNS injuries and disorders.
Wed Sep 01 00:00:00 EDT 2021
Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.
Journal of hematology & oncology
Kim HR,Park JS,Park JH,Yasmin F,Kim CH,Oh SK,Chung IJ,Jun CD
17-0114 was used in Flow cytometry/Cell sorting to indicate that cell-permeable transgelin-2 have a potential clinical value as a cancer immunotherapy based on DCs.
Wed Mar 17 00:00:00 EDT 2021
Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40.
Nature communications
Yang F,He Z,Duan H,Zhang D,Li J,Yang H,Dorsey JF,Zou W,Nabavizadeh SA,Bagley SJ,Abdullah K,Brem S,Zhang L,Xu X,Byrne KT,Vonderheide RH,Gong Y,Fan Y
17-0114-82 was used in Flow Cytometry to investigate if an antibody cocktail-based immunotherapy that combines checkpoint blockade with dual-targeting of IL-6 and CD40 may offer exciting opportunities for glioblastoma and other solid tumors.
Tue Jun 08 00:00:00 EDT 2021
Rate of Freeze Impacts the Survival and Immune Responses Post Cryoablation of Melanoma.
Frontiers in immunology
Yakkala C,Dagher J,Sempoux C,Chiang CL,Denys A,Kandalaft LE,Koppolu B,Duran R
17-0114-82 was used in Flow Cytometry to study fast freeze and slow freeze rates for their locoregional effectiveness and their ability to elicit immune responses in a B16F10 mouse model of melanoma.
Mon Dec 13 00:00:00 EST 2021
SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis.
iScience
Sangaletti S,Botti L,Gulino A,Lecis D,Bassani B,Portararo P,Milani M,Cancila V,De Cecco L,Dugo M,Tripodo C,Colombo MP
17-0114-82 was used in Flow Cytometry to investigate the role of secreted protein acidic and rich in cysteine in autoimmunity using the pristane-induced model of lupus that, in mice, mimics human systemic lupus erythematosus (SLE).
Fri Jun 25 00:00:00 EDT 2021
Genomic and epigenomic adaptation in SP-R210 (Myo18A) isoform-deficient macrophages.
Immunobiology
Yau E,Chen Y,Song C,Webb J,Carillo M,Kawasawa YI,Tang Z,Takahashi Y,Umstead TM,Dovat S,Chroneos ZC
17-0114-82 was used in Flow Cytometry to suggest that the inflammatory differences seen in SP-R210L-deficient macrophages are a result of transcriptional differences that are mediated by epigenetic changes brought about by differential expression of the SP-R210 isoforms.
Mon Nov 01 00:00:00 EDT 2021
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.
Cell
Lee JY,Hall JA,Kroehling L,Wu L,Najar T,Nguyen HH,Lin WY,Yeung ST,Silva HM,Li D,Hine A,Loke P,Hudesman D,Martin JC,Kenigsberg E,Merad M,Khanna KM,Littman DR
17-0114 was used in Flow cytometry/Cell sorting to suggest that serum amyloid A proteins direct a pathogenic pro-inflammatory Th17 cell differentiation program and promote Th17-mediated inflammatory diseases.
Thu Jan 09 00:00:00 EST 2020
Cellular and Molecular Mechanisms of Kidney Injury in 2,8-Dihydroxyadenine Nephropathy.
Journal of the American Society of Nephrology : JASN
Klinkhammer BM,Djudjaj S,Kunter U,Palsson R,Edvardsson VO,Wiech T,Thorsteinsdottir M,Hardarson S,Foresto-Neto O,Mulay SR,Moeller MJ,Jahnen-Dechent W,Floege J,Anders HJ,Boor P
17-0114 was used in Immunohistochemistry to assess the pathogenic sequelae of 2,8-DHA crystal-induced kidney damage.
Wed Apr 01 00:00:00 EDT 2020
Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages.
EMBO molecular medicine
Menga A,Serra M,Todisco S,Riera-Domingo C,Ammarah U,Ehling M,Palmieri EM,Di Noia MA,Gissi R,Favia M,Pierri CL,Porporato PE,Castegna A,Mazzone M
17-0114 was used in Flow cytometry/Cell sorting to evaluate the pharmacological potential of Glutamine synthetase (GS) inhibitors in targeting metastasis.
Wed Oct 07 00:00:00 EDT 2020
The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.
Proceedings of the National Academy of Sciences of the United States of America
Kitchen GB,Cunningham PS,Poolman TM,Iqbal M,Maidstone R,Baxter M,Bagnall J,Begley N,Saer B,Hussell T,Matthews LC,Dockrell DH,Durrington HJ,Gibbs JE,Blaikley JF,Loudon AS,Ray DW
17-0114-82 was used in Flow Cytometry to show that loss of the core clock protein BMAL1 in macrophages confers protection against pneumococcal pneumonia.
Tue Jan 21 00:00:00 EST 2020
In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2.
Molecular therapy oncolytics
Liu W,Dai E,Liu Z,Ma C,Guo ZS,Bartlett DL
17-0114 was used in Flow cytometry/Cell sorting to establish in situ anticancer immunotherapy regimens.
Fri Jun 26 00:00:00 EDT 2020
C5aR1 Activation Drives Early IFN-γ Production to Control Experimental Toxoplasma gondii Infection.
Frontiers in immunology
Briukhovetska D,Ohm B,Mey FT,Aliberti J,Kleingarn M,Huber-Lang M,Karsten CM,Köhl J
17-0114 was used in Flow cytometry/Cell sorting to suggest a model in which the C5a/C5aR1 axis promotes IFN-γ production from NK cells as a mechanism to control acute Toxoplasma gondii infection.
Mon Apr 05 00:00:00 EDT 2021
Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs.
Cell reports
Gallizioli M,Miró-Mur F,Otxoa-de-Amezaga A,Cugota R,Salas-Perdomo A,Justicia C,Brait VH,Ruiz-Jaén F,Arbaizar-Rovirosa M,Pedragosa J,Bonfill-Teixidor E,Gelderblom M,Magnus T,Cano E,Del Fresno C,Sancho D,Planas AM
17-0114 was used in Flow cytometry/Cell sorting to reveal aspects of the dynamics and functions of brain DCs in the regulation of inflammation and immunity.
Tue Oct 20 00:00:00 EDT 2020
CD279 mediates the homeostasis and survival of regulatory T cells by enhancing T cell and macrophage interactions.
FEBS open bio
Liu Y,Gao Y,Hao H,Hou T
17-0114 was used in Flow cytometry/Cell sorting to show that antibody-mediated inhibition of CD279 reduces T cell survival in bone marrow in vivo.
Mon Jun 01 00:00:00 EDT 2020
Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 Inflammasome.
Frontiers in immunology
Hou L,Yang L,Chang N,Zhao X,Zhou X,Dong C,Liu F,Yang L,Li L
17-0114 was used in Flow cytometry/Cell sorting to show that targeting macrophage S1PR2 retarded liver inflammation and fibrogenesis via downregulating NLRP3 inflammasome.
Thu Apr 01 00:00:00 EDT 2021
The Innate Immune Response to Infection Induces Erythropoietin-Dependent Replenishment of the Dendritic Cell Compartment.
Frontiers in immunology
Einwächter H,Heiseke A,Schlitzer A,Gasteiger G,Adler H,Voehringer D,Manz MG,Ruzsics Z,Dölken L,Koszinowski UH,Sparwasser T,Reindl W,Jordan S
17-0114-82 was used in Flow Cytometry to investigate the molecular and cellular mechanisms of inflammation-induced dendritic cell generation.
Mon Apr 19 00:00:00 EDT 2021
Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming.
Cell reports
McDaniel MM,Kottyan LC,Singh H,Pasare C
17-0114 was used in Flow cytometry/Cell sorting to show that conventional denritic cells suppress inflammasome activationby IRF4 and IRF8 to prevent pyroptotic cell death, thus preserving their ability to prime both CD4 and CD8 T cells.
Tue May 05 00:00:00 EDT 2020
MyD88-dependent signaling in non-parenchymal cells promotes liver carcinogenesis.
Carcinogenesis
Mohs A,Kuttkat N,Otto T,Youssef SA,De Bruin A,Trautwein C
17-0114-82 was used in Flow cytometry/Cell sorting to suggest that signaling of Toll-like receptors through MyD88 in non-parenchymal liver cells is required for carcinogenesis during chronic liver injury.
Wed Apr 22 00:00:00 EDT 2020
Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing.
Nature
Mahmoudi S,Mancini E,Xu L,Moore A,Jahanbani F,Hebestreit K,Srinivasan R,Li X,Devarajan K,Prélot L,Ang CE,Shibuya Y,Benayoun BA,Chang ALS,Wernig M,Wysocka J,Longaker MT,Snyder MP,Brunet A
17-0114 was used in Flow cytometry/Cell sorting to show that this variability may reflect distinct stochastic ageing trajectories between individuals, and could help in developing personalized strategies to improve iPS cell generation and wound healing in elderly individuals.
Tue Oct 01 00:00:00 EDT 2019
Compartmentalized gut lymph node drainage dictates adaptive immune responses.
Nature
Esterházy D,Canesso MCC,Mesin L,Muller PA,de Castro TBR,Lockhart A,ElJalby M,Faria AMC,Mucida D
17-0114-82 was used in Flow Cytometry to show drainage of gut-draining lymph nodes can resolve conflicting tolerogenic and inflammatory intestinal responses by encouraging antigen targeting to specific gut segments.
Wed May 01 00:00:00 EDT 2019
Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells.
Immunity
Tibbitt CA,Stark JM,Martens L,Ma J,Mold JE,Deswarte K,Oliynyk G,Feng X,Lambrecht BN,De Bleser P,Nylén S,Hammad H,Arsenian Henriksson M,Saeys Y,Coquet JM
17-0114-82 was used in Flow cytometry/Cell sorting to provide insight into the differentiation of pathogenic Th2 cells in the context of allergy.
Tue Jul 16 00:00:00 EDT 2019
Podoplanin-Expressing Macrophages Promote Lymphangiogenesis and Lymphoinvasion in Breast Cancer.
Cell metabolism
Bieniasz-Krzywiec P,Martín-Pérez R,Ehling M,García-Caballero M,Pinioti S,Pretto S,Kroes R,Aldeni C,Di Matteo M,Prenen H,Tribulatti MV,Campetella O,Smeets A,Noel A,Floris G,Van Ginderachter JA,Mazzone M
17-0114-82 was used in Flow cytometry/Cell sorting to investigate if podoplanin is involved in the attachment of tumor-associated macrophages subset to lymphatic endothelial cells (LECs).
Tue Nov 05 00:00:00 EST 2019
Low-Dose Apatinib Optimizes Tumor Microenvironment and Potentiates Antitumor Effect of PD-1/PD-L1 Blockade in Lung Cancer.
Cancer immunology research
Zhao S,Ren S,Jiang T,Zhu B,Li X,Zhao C,Jia Y,Shi J,Zhang L,Liu X,Qiao M,Chen X,Su C,Yu H,Zhou C,Zhang J,Camidge DR,Hirsch FR
17-0114 was used in Flow cytometry/Cell sorting to analyze the impact of apatinib, a smallmolecule VEGFR2-TKI, on the TME in murine Lewis lung carcinoma (LLC) models at different doses alone and in combination with an anti–PD-L1.
Mon Apr 01 00:00:00 EDT 2019
Induction of autophagy in Cx3cr1+ mononuclear cells limits IL-23/IL-22 axis-mediated intestinal fibrosis.
Mucosal immunology
Mathur R,Alam MM,Zhao XF,Liao Y,Shen J,Morgan S,Huang T,Lee H,Lee E,Huang Y,Zhu X
17-0114-82 was used in Flow Cytometry to reveal that the IL-23/IL-22 axis is up regulated in human Crohn’s patients and in the TNBS model of intestinal fibrosis in both wild-type and Rag−/− mice.
Wed May 01 00:00:00 EDT 2019
Epigenetically modulated FOXM1 suppresses dendritic cell maturation in pancreatic cancer and colon cancer.
Molecular oncology
Zhou Z,Chen H,Xie R,Wang H,Li S,Xu Q,Xu N,Cheng Q,Qian Y,Huang R,Shao Z,Xiang M
17-0114 was used in Flow cytometry/Cell sorting to show that upregulation of FOXM1 by H3K79me2 in pancreatic cancer and colon cancer significantly inhibits maturation phenotypes and function of bone marrow dendritic cells (BMDCs) through the Wnt5a signaling pathway, and thus provide novel insights into FOXM1-based antitumor immunotherapy.
Mon Apr 01 00:00:00 EDT 2019
Genome-wide effect of pulmonary airway epithelial cell-specific Bmal1 deletion.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Zhang Z,Hunter L,Wu G,Maidstone R,Mizoro Y,Vonslow R,Fife M,Hopwood T,Begley N,Saer B,Wang P,Cunningham P,Baxter M,Durrington H,Blaikley JF,Hussell T,Rattray M,Hogenesch JB,Gibbs J,Ray DW,Loudon ASI
17-0114-82 was used in Flow Cytometry to find that metabolic cues dictate phasing of the pulmonary clock and circadian responses to immunologic challenges.
Wed May 01 00:00:00 EDT 2019
Distinct Roles of α7 nAChRs in Antigen-Presenting Cells and CD4+ T Cells in the Regulation of T Cell Differentiation.
Frontiers in immunology
Mashimo M,Komori M,Matsui YY,Murase MX,Fujii T,Takeshima S,Okuyama H,Ono S,Moriwaki Y,Misawa H,Kawashima K
17-0114 was used in Flow cytometry/Cell sorting to investigate the specific function α7 nAChRs on T cells and antigen presenting cells (APCs) in mice.
Fri Aug 21 00:00:00 EDT 2020
Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation.
Cell reports
Ciecko AE,Foda B,Barr JY,Ramanathan S,Atkinson MA,Serreze DV,Geurts AM,Lieberman SM,Chen YG
17-0114-82 was used in Flow Cytometry to reveal that IL-27 contributes to autoimmunity in NOD mice through multiple mechanisms and provides substantial evidence to support its pathogenic role in human T1D.
Tue Dec 03 00:00:00 EST 2019
Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity.
Nature metabolism
Seo JB,Riopel M,Cabrales P,Huh JY,Bandyopadhyay GK,Andreyev AY,Murphy AN,Beeman SC,Smith GI,Klein S,Lee YS,Olefsky JM
17-0114-82 was used in Flow Cytometry to demonstrate that increased adipocyte O2 demand, mediated by ANT2 activity, is the dominant cause of adipocyte hypoxia.
Tue Jan 01 00:00:00 EST 2019
Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-κB/TNF-α pathway.
Molecular metabolism
Yang H,Xie T,Li D,Du X,Wang T,Li C,Song X,Xu L,Yi F,Liang X,Gao L,Yang X,Ma C
17-0114 was used in Flow cytometry/Cell sorting to study T cell immunoglobulin domain and mucin domain-3 as a regulator in renal inflammation.
Wed May 01 00:00:00 EDT 2019
Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells.
Frontiers in immunology
Zwick M,Ulas T,Cho YL,Ried C,Grosse L,Simon C,Bernhard C,Busch DH,Schultze JL,Buchholz VR,Stutte S,Brocker T
17-0114-82 was used in Flow Cytometry to suggest that Ppef2 is crucial to support survival of immature CD8+ DCs, while Ppef2 down-regulation during DC-maturation limits T cell responses.
Tue Oct 27 00:00:00 EDT 2020
The CARD9-Associated C-Type Lectin, Mincle, Recognizes La Crosse Virus (LACV) but Plays a Limited Role in Early Antiviral Responses against LACV.
Viruses
Monteiro JT,Schön K,Ebbecke T,Goethe R,Ruland J,Baumgärtner W,Becker SC,Lepenies B
17-0114-82 was used in Flow Cytometry to investigate the role of additional C-type lectin receptors/La Crosse virus interactions.
Tue Mar 26 00:00:00 EDT 2019
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.
Nature neuroscience
Louveau A,Herz J,Alme MN,Salvador AF,Dong MQ,Viar KE,Herod SG,Knopp J,Setliff JC,Lupi AL,Da Mesquita S,Frost EL,Gaultier A,Harris TH,Cao R,Hu S,Lukens JR,Smirnov I,Overall CC,Oliver G,Kipnis J
17-0114 was used in Flow cytometry/Cell sorting to demonstrate that meningeal lymphatics fulfill two critical criteria: they assist in the drainage of cerebrospinal fluid components and enable immune cells to enter draining lymph nodes in a CCR7-dependent manner.
Mon Oct 01 00:00:00 EDT 2018
PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy.
The Journal of clinical investigation
Zamarin D,Ricca JM,Sadekova S,Oseledchyk A,Yu Y,Blumenschein WM,Wong J,Gigoux M,Merghoub T,Wolchok JD
Mon Apr 02 00:00:00 EDT 2018
An OX40/OX40L interaction directs successful immunity to hepatitis B virus.
Science translational medicine
Publicover J,Gaggar A,Jespersen JM,Halac U,Johnson AJ,Goodsell A,Avanesyan L,Nishimura SL,Holdorf M,Mansfield KG,Judge JB,Koshti A,Croft M,Wakil AE,Rosenthal P,Pai E,Cooper S,Baron JL
17-0114 was used in Flow cytometry/Cell sorting to study the mechanistic action of the immune pathways and cells necessary for HBV immunity and identify potential therapeutic targets for resolving chronic HBV infection.
Wed Mar 21 00:00:00 EDT 2018
Protective role of γδ T cells in cigarette smoke and influenza infection.
Mucosal immunology
Hong MJ,Gu BH,Madison MC,Landers C,Tung HY,Kim M,Yuan X,You R,Machado AA,Gilbert BE,Soroosh P,Elloso M,Song L,Chen M,Corry DB,Diehl G,Kheradmand F
17-0114 was used in Flow cytometry/Cell sorting to demonstrate that cigarette smoke induces IL-17A expression in the lungs and inhibits γδ T-cell-mediated protective anti-viral immune responses.
Tue May 01 00:00:00 EDT 2018
Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice.
Cell reports
Omata Y,Frech M,Primbs T,Lucas S,Andreev D,Scholtysek C,Sarter K,Kindermann M,Yeremenko N,Baeten DL,Andreas N,Kamradt T,Bozec A,Ramming A,Krönke G,Wirtz S,Schett G,Zaiss MM
17-0114 was used in Flow cytometry/Cell sorting to elucidate the role of group 2 innate lymphoid cells in arthritis.
Tue Jul 03 00:00:00 EDT 2018
Lin-CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade.
Nature communications
Flores CT,Wildes TJ,Drake JA,Moore GL,Dean BD,Abraham RS,Mitchell DA
Wed Oct 17 00:00:00 EDT 2018
The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma.
Nature communications
Soncin I,Sheng J,Chen Q,Foo S,Duan K,Lum J,Poidinger M,Zolezzi F,Karjalainen K,Ruedl C
17-0114 was used in Flow cytometry/Cell sorting to study the creation of an isolated niche in the tumour microenvironment for tissue-resident macrophages that favours macrophage survival and self-renewal.
Thu Feb 08 00:00:00 EST 2018
Estriol Reduces Pulmonary Immune Cell Recruitment and Inflammation to Protect Female Mice From Severe Influenza.
Endocrinology
Vermillion MS,Ursin RL,Attreed SE,Klein SL
17-0114-82 was used in Flow cytometry/Cell sorting to suggest that exogenous E3 confers protection during IAV infection through immunomodulatory mechanisms and that E3 may have broad therapeutic potential in the context of both infectious and noninfectious inflammatory diseases.
Sat Sep 01 00:00:00 EDT 2018
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
17-0114 was used in Flow cytometry/Cell sorting to identify a regulatory subpopulation of innate lymphoid cells that exists in the gut, and harbour a unique gene identity.
Thu Sep 21 00:00:00 EDT 2017
Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity.
Cell
Ying W,Riopel M,Bandyopadhyay G,Dong Y,Birmingham A,Seo JB,Ofrecio JM,Wollam J,Hernandez-Carretero A,Fu W,Li P,Olefsky JM
17-0114 was used in Flow cytometry/Cell sorting to study the secretion of exosomes containing miRNA cargo by adipose tissue macrophages.
Thu Oct 05 00:00:00 EDT 2017
Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.
Cancer cell
Seaman S,Zhu Z,Saha S,Zhang XM,Yang MY,Hilton MB,Morris K,Szot C,Morris H,Swing DA,Tessarollo L,Smith SW,Degrado S,Borkin D,Jain N,Scheiermann J,Feng Y,Wang Y,Li J,Welsch D,DeCrescenzo G,Chaudhary A,Zudaire E,Klarmann KD,Keller JR,Dimitrov DS,St Croix B
17-0114 was used in Flow cytometry/Cell sorting to demonstrate that the cell surface protein CD276/B7-H3 is broadly over-expressed by multiple tumour types on both cancer cells and tumour-infiltrating blood vessels, making it a potentially ideal dual-compartment therapeutic target.
Mon Apr 10 00:00:00 EDT 2017
Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.
The Journal of experimental medicine
Thomas DC,Clare S,Sowerby JM,Pardo M,Juss JK,Goulding DA,van der Weyden L,Storisteanu D,Prakash A,Espéli M,Flint S,Lee JC,Hoenderdos K,Kane L,Harcourt K,Mukhopadhyay S,Umrania Y,Antrobus R,Nathan JA,Adams DJ,Bateman A,Choudhary JS,Lyons PA,Condliffe AM,Chilvers ER,Dougan G,Smith KG
17-0114 was used in Flow cytometry/Cell sorting to describe the key role of the previously uncharacterised protein Eros in host defence.
Mon Apr 03 00:00:00 EDT 2017
Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.
Cancer research
Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B
17-0114-82 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.
Wed Nov 01 00:00:00 EDT 2017
Dectin-2 is a primary receptor for NLRP3 inflammasome activation in dendritic cell response to Histoplasma capsulatum.
PLoS pathogens
Chang TH,Huang JH,Lin HC,Chen WY,Lee YH,Hsu LC,Netea MG,Ting JP,Wu-Hsieh BA
17-0114 was used in Flow cytometry/Cell sorting to investigate how H. capsulatum induces inflammasome activation and IL-1β production, showing that dectin-2 is a primary receptor for NLRP3 inflammasome activation.
Sat Jul 01 00:00:00 EDT 2017
Semaphorin 3E Deficiency Exacerbates Airway Inflammation, Hyperresponsiveness, and Remodeling in a Mouse Model of Allergic Asthma.
Journal of immunology (Baltimore, Md. : 1950)
Movassagh H,Shan L,Mohammed A,Halayko AJ,Gounni AS
17-0114 was used in Flow cytometry/Cell sorting to identify Semaphorin 3E as a novel regulatory molecule in allergic asthma that acts upstream of proallergic events.
Wed Mar 01 00:00:00 EST 2017
Allogeneic Adipose-Derived Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Regulating Self-Reactive T Cell Responses and Dendritic Cell Function.
Stem cells international
Anderson P,Gonzalez-Rey E,O'Valle F,Martin F,Oliver FJ,Delgado M
Wed Sep 30 00:00:00 EDT 2020
Batf3-dependent CD8α+ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.
EBioMedicine
Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H
17-0114 was used in Flow cytometry/Cell sorting to show that Batf3-/-Apoe-/- mice, lacking CD8α+ DCs, exhibited a significant reduction in atherogenesis and T help 1 (Th1) cells compared with Apoe-/- controls.
Sat Apr 01 00:00:00 EDT 2017
Leucine-Rich Repeat Kinase 2 (Lrrk2)-Sensitive Na+/K+ ATPase Activity in Dendritic Cells.
Scientific reports
Hosseinzadeh Z,Singh Y,Shimshek DR,van der Putten H,Wagner CA,Lang F
17-0114 was used in Flow cytometry/Cell sorting to demonstrate that Lrrk2 is a strong regulator of Na+/K+ -ATPase expression and activity in dendritic cells.
Wed Jan 25 00:00:00 EST 2017
Modulation of Innate Immunity by lignin-Carbohydrate, a Novel TLR4 Ligand, Results in Augmentation of Mucosal IgA and Systemic IgG Production.
International journal of molecular sciences
Tsuji R,Ikado K,Fujiwara D
17-0114 was used in Flow cytometry/Cell sorting to investigate immune-stimulatory activity of lignin-rich enzyme lignin in vivo.
Tue Dec 26 00:00:00 EST 2017
Isolation and Analysis of Stromal Vascular Cells from Visceral Adipose Tissue.
Bio-protocol
Vu J,Ying W
17-0114-82 was used in Flow Cytometry to show that these SVCs can be used to examine the population and activation status of immune cells by tracking their cell surface antigens, gene expression, and activation of specific signaling pathways.
Sun Aug 20 00:00:00 EDT 2017
Cytokine and hormonal regulation of bone marrow immune cell Wnt10b expression.
PloS one
Collins FL,Rios-Arce ND,McCabe LR,Parameswaran N
17-0114 was used in Flow cytometry/Cell sorting to determine the potential regulation of Wnt10b by estrogen and TNFα, showing regulation of expression by cytokines and hormones.
Mon Oct 09 00:00:00 EDT 2017
Differential regulation of C5a receptor 1 in innate immune cells during the allergic asthma effector phase.
PloS one
Ender F,Wiese AV,Schmudde I,Sun J,Vollbrandt T,König P,Laumonnier Y,Köhl J
17-0114 was used in Flow cytometry/Cell sorting to demonstrate a complex regulation pattern of C5aR1 in the airways, lung tissue and lymph nodes of mice.
Thu Aug 17 00:00:00 EDT 2017
Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway.
EBioMedicine
Lirussi D,Ebensen T,Schulze K,Trittel S,Duran V,Liebich I,Kalinke U,Guzmán CA
17-0114 was used in Flow Cytometry to demonstrate that stimulation of interferon-γ-secreting CD8+ cytotoxic T lymphocytes is significantly decreased after vaccination in the absence of type I interferon signalling.
Tue Aug 01 00:00:00 EDT 2017
E3 ligase FBXW7 is critical for RIG-I stabilization during antiviral responses.
Nature communications
Song Y,Lai L,Chong Z,He J,Zhang Y,Xue Y,Xie Y,Chen S,Dong P,Chen L,Chen Z,Dai F,Wan X,Xiao P,Cao X,Liu Y,Wang Q
17-0114 was used in Flow cytometry/Cell sorting to identify FBXW7 as an important interacting partner for RIG-I.
Mon Mar 13 00:00:00 EDT 2017
CD36 receptor regulates malaria-induced immune responses primarily at early blood stage infection contributing to parasitemia control and resistance to mortality.
The Journal of biological chemistry
Thylur RP,Wu X,Gowda NM,Punnath K,Neelgund SE,Febbraio M,Gowda DC
17-0114 was used in Flow cytometry/Cell sorting to study the function of CD36 in malaria immunity.
Fri Jun 02 00:00:00 EDT 2017
Specific calpain inhibition protects kidney against inflammaging.
Scientific reports
Hanouna G,Mesnard L,Vandermeersch S,Perez J,Placier S,Haymann JP,Campagne F,Moroch J,Bataille A,Baud L,Letavernier E
17-0114 was used in Flow cytometry/Cell sorting to study how calpains inhibition protects against inflammaging, limiting kidney and vascular lesions related to aging.
Mon Aug 14 00:00:00 EDT 2017
IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis.
Scientific reports
Peshkova IO,Fatkhullina AR,Mikulski Z,Ley K,Koltsova EK
17-0114 was used in Flow cytometry/Cell sorting to study the role of IL-27R in controlling myeloid cell accumulation and activation in atherosclerosis.
Tue May 23 00:00:00 EDT 2017
STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells.
Nature communications
Nunes-Hasler P,Maschalidi S,Lippens C,Castelbou C,Bouvet S,Guido D,Bermont F,Bassoy EY,Page N,Merkler D,Hugues S,Martinvalet D,Manoury B,Demaurex N
17-0114 was used in Flow cytometry/Cell sorting to show that ablation of the store-operated-Ca2+-entry regulator STIM1 in mouse myeloid cells impairs cross-presentation and dendritic cell migration in vivo and in vitro.
Fri Nov 24 00:00:00 EST 2017
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity.
Science translational medicine
Dendrou CA,Cortes A,Shipman L,Evans HG,Attfield KE,Jostins L,Barber T,Kaur G,Kuttikkatte SB,Leach OA,Desel C,Faergeman SL,Cheeseman J,Neville MJ,Sawcer S,Compston A,Johnson AR,Everett C,Bell JI,Karpe F,Ultsch M,Eigenbrot C,McVean G,Fugger L
17-0114 was used in Flow cytometry/Cell sorting to reveal a protective homozygous effect that defined a signalling optimum between autoimmunity and immunodeficiency and identified TYK2 as a potential drug target for autoimmune disorders.
Wed Nov 02 00:00:00 EDT 2016
Extracellular matrix mediators of metastatic cell colonization characterized using scaffold mimics of the pre-metastatic niche.
Acta biomaterialia
Aguado BA,Caffe JR,Nanavati D,Rao SS,Bushnell GG,Azarin SM,Shea LD
17-0114 was used in Flow cytometry/Cell sorting to identify and validate novel ECM contributors to tumour cell colonisation.
Tue Mar 01 00:00:00 EST 2016
β7-Integrin exacerbates experimental DSS-induced colitis in mice by directing inflammatory monocytes into the colon.
Mucosal immunology
Schippers A,Muschaweck M,Clahsen T,Tautorat S,Grieb L,Tenbrock K,Gaßler N,Wagner N
17-0114 was used in Flow cytometry/Cell sorting to elucidate the significance of β7-integrin expression on innate immune cells for the pathogenesis of inflammatory bowel disease.
Tue Mar 01 00:00:00 EST 2016
Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation.
Mucosal immunology
Yang BH,Hagemann S,Mamareli P,Lauer U,Hoffmann U,Beckstette M,Föhse L,Prinz I,Pezoldt J,Suerbaum S,Sparwasser T,Hamann A,Floess S,Huehn J,Lochner M
17-0114 was used in Flow cytometry/Cell sorting to demonstrate that Foxp3(+) T cells expressing retinoic acid-related orphan receptor-γt, represent a stable regulatory T cell lineage with a highly suppressive phenotype in vivo.
Tue Mar 01 00:00:00 EST 2016
Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase.
PLoS pathogens
Huang L,Ou R,Rabelo de Souza G,Cunha TM,Lemos H,Mohamed E,Li L,Pacholczyk G,Randall J,Munn DH,Mellor AL
17-0114 was used in Flow cytometry/Cell sorting to support the hypothesis that elevated IDO activity in non-CNS due to virus infections causes pain hypersensitivity mediated by Kyn.
Sun May 01 00:00:00 EDT 2016
Real-time in vivo imaging reveals the ability of neutrophils to remove Cryptococcus neoformans directly from the brain vasculature.
Journal of leukocyte biology
Zhang M,Sun D,Liu G,Wu H,Zhou H,Shi M
17-0114 was used in Flow cytometry/Cell sorting to demonstrate direct removal of Cryptococcus neoformans by neutrophils from its arrested site as a potential host defense mechanism.
Tue Mar 01 00:00:00 EST 2016
Repulsive guidance molecule a blockade exerts the immunoregulatory function in DCs stimulated with ABP and LPS.
Human vaccines & immunotherapeutics
Xu X,Gao Y,Zhai Z,Zhang S,Shan F,Feng J
17-0114 was used in Flow cytometry/Cell sorting to show that dendritic cells treated with RGMa-neutralising antibodies present with tolerogenic and immunoregulatory characteristics.
Tue Aug 02 00:00:00 EDT 2016
MyD88 Mediates Instructive Signaling in Dendritic Cells and Protective Inflammatory Response during Rickettsial Infection.
Infection and immunity
Bechelli J,Smalley C,Zhao X,Judy B,Valdes P,Walker DH,Fang R
17-0114 was used in Flow cytometry/Cell sorting to study host susceptibility of MyD88(-/-)mice to infection with Rickettsia conorii or Rickettsia australis.
Fri Apr 01 00:00:00 EDT 2016
Proteomic Analysis of Excretory-Secretory Products of Mesocestoides corti Metacestodes Reveals Potential Suppressors of Dendritic Cell Functions.
PLoS neglected tropical diseases
Vendelova E,Camargo de Lima J,Lorenzatto KR,Monteiro KM,Mueller T,Veepaschit J,Grimm C,Brehm K,Hrčková G,Lutz MB,Ferreira HB,Nono JK
17-0114 was used in Flow cytometry/Cell sorting to study the immunomodulatory effects of excretory-secretory products derived from M. corti tetrathyridia.
Sat Oct 01 00:00:00 EDT 2016
Evaluation of Cross-presentation in Bone Marrow-derived Dendritic Cells in vitro and Splenic Dendritic Cells ex vivo Using Antigen-coated Beads.
Bio-protocol
Alloatti A,Kotsias F,Hoffmann E,Amigorena S
17-0114 was used in Flow cytometry/Cell sorting to develop a protocol for evaluating antigen cross-presentation by dendritic cells, both in vivo and ex vivo.
Sun Nov 20 00:00:00 EST 2016
B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation.
Scientific reports
Bjarnadóttir K,Benkhoucha M,Merkler D,Weber MS,Payne NL,Bernard CCA,Molnarfi N,Lalive PH
17-0114-82 was used in Flow Cytometry to test the role for transforming growth factor-β1 expression in regulatory B cell function in autoimmune neuroinflammation.
Thu Oct 06 00:00:00 EDT 2016
High Fat Diet Inhibits Dendritic Cell and T Cell Response to Allergens but Does Not Impair Inhalational Respiratory Tolerance.
PloS one
Pizzolla A,Oh DY,Luong S,Prickett SR,Henstridge DC,Febbraio MA,O'Hehir RE,Rolland JM,Hardy CL
17-0114 was used in Flow cytometry/Cell sorting to study the relationship between a high fat diet and allergic asthma using an induced-respiratory tolerance model in mice.
Wed Jul 26 00:00:00 EDT 2017
ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation.
eLife
Pearson C,Thornton EE,McKenzie B,Schaupp AL,Huskens N,Griseri T,West N,Tung S,Seddon BP,Uhlig HH,Powrie F
17-0114 was used in Immunofluorescence on frozen tissues to investigate how a small population of innate lymphoid cells (ILCs) has large effects on immune homeostasis, showing that ILC3s produce GM-CSF to orchestrate acute intestinal inflammation.
Mon Jan 18 00:00:00 EST 2016
Cell Type Preference of a Novel Human Derived Cell-Permeable Peptide dNP2 and TAT in Murine Splenic Immune Cells.
PloS one
Lim S,Lee JA,Koo JH,Kang TG,Ha SJ,Choi JM
17-0114 was used in Flow cytometry/Cell sorting to demonstrate that uptake of cell-permeable peptides differs between phagocytic and non-phagocytic immune cells.
Tue Jul 11 00:00:00 EDT 2017
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
Nature medicine
Wilson JE,Petrucelli AS,Chen L,Koblansky AA,Truax AD,Oyama Y,Rogers AB,Brickey WJ,Wang Y,Schneider M,Mühlbauer M,Chou WC,Barker BR,Jobin C,Allbritton NL,Ramsden DA,Davis BK,Ting JP
17-0114 was used in Flow cytometry/Cell sorting to show AIM2 regulates colon tumorigenesis by reducing activation of both DNA-PK and Akt, suggesting that Akt inhibitors could be used in treatment of certain cancers.
Sat Aug 01 00:00:00 EDT 2015
Keratin-dependent regulation of Aire and gene expression in skin tumor keratinocytes.
Nature genetics
Hobbs RP,DePianto DJ,Jacob JT,Han MC,Chung BM,Batazzi AS,Poll BG,Guo Y,Han J,Ong S,Zheng W,Taube JM,Čiháková D,Wan F,Coulombe PA
17-0114 was used in Flow cytometry/Cell sorting to provide new insight into keratin intermediate filament and Aire function, as well as a molecular basis for the K17-dependent amplification of inflammatory and immune responses in diseased epithelia.
Sat Aug 01 00:00:00 EDT 2015
The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote T(H)17 cell-dependent emphysema.
Nature immunology
Lu W,You R,Yuan X,Yang T,Samuel EL,Marcano DC,Sikkema WK,Tour JM,Rodriguez A,Kheradmand F,Corry DB
17-0114 was used in Flow cytometry/Cell sorting to show that miR-22 expression was upregulated as a consequence of smoking and contributes to the development of emphysema.
Sun Nov 01 00:00:00 EDT 2015
Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.
Nature immunology
Laidlaw BJ,Cui W,Amezquita RA,Gray SM,Guan T,Lu Y,Kobayashi Y,Flavell RA,Kleinstein SH,Craft J,Kaech SM
17-0114 was used in Flow cytometry/Cell sorting to that Treg cell-derived IL-10 is needed to insulate, and promote the quality of, developing CD8(+) T cells.
Sat Aug 01 00:00:00 EDT 2015
Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses.
The Journal of experimental medicine
Sawada Y,Honda T,Hanakawa S,Nakamizo S,Murata T,Ueharaguchi-Tanada Y,Ono S,Amano W,Nakajima S,Egawa G,Tanizaki H,Otsuka A,Kitoh A,Dainichi T,Ogawa N,Kobayashi Y,Yokomizo T,Arita M,Nakamura M,Miyachi Y,Kabashima K
17-0114 was used in Flow cytometry/Cell sorting to study the inhibition of dendritic cell migration in the skin and the attenuation of contact hypersensitivity responses via Resolvin E1.
Mon Oct 19 00:00:00 EDT 2015
Antigen delivery by filamentous bacteriophage fd displaying an anti-DEC-205 single-chain variable fragment confers adjuvanticity by triggering a TLR9-mediated immune response.
EMBO molecular medicine
Sartorius R,D'Apice L,Trovato M,Cuccaro F,Costa V,De Leo MG,Marzullo VM,Biondo C,D'Auria S,De Matteis MA,Ciccodicola A,De Berardinis P
17-0114 was used in Flow cytometry/Cell sorting to reveal the fd bacteriophage as a valuable tool for immunization without administering exogenous adjuvants.
Wed Jul 01 00:00:00 EDT 2015
Nanoparticulate carbon black in cigarette smoke induces DNA cleavage and Th17-mediated emphysema.
eLife
You R,Lu W,Shan M,Berlin JM,Samuel EL,Marcano DC,Sun Z,Sikkema WK,Yuan X,Song L,Hendrix AY,Tour JM,Corry DB,Kheradmand F
17-0114 was used in Flow cytometry/Cell sorting to show that insoluble nanoparticulate carbon black accumulates in human myeloid dendritic cells (mDCs) from emphysematous lung and in CD11c(+) lung antigen presenting cells of mice exposed to smoke.
Mon Oct 05 00:00:00 EDT 2015
Peptide-MHC-I from Endogenous Antigen Outnumber Those from Exogenous Antigen, Irrespective of APC Phenotype or Activation.
PLoS pathogens
Sei JJ,Haskett S,Kaminsky LW,Lin E,Truckenmiller ME,Bellone CJ,Buller RM,Norbury CC
17-0114 was used in Immunofluorescence to suggest that direct antigen presentation is the dominant pathway in mice during mousepox.
Mon Jun 01 00:00:00 EDT 2015
Peptide-MHC-I from Endogenous Antigen Outnumber Those from Exogenous Antigen, Irrespective of APC Phenotype or Activation.
PLoS pathogens
Sei JJ,Haskett S,Kaminsky LW,Lin E,Truckenmiller ME,Bellone CJ,Buller RM,Norbury CC
17-0114 was used in Immunofluorescence to suggest that direct antigen presentation is the dominant pathway in mice during mousepox.
Mon Jun 01 00:00:00 EDT 2015
A novel Cd8-cis-regulatory element preferentially directs expression in CD44hiCD62L+ CD8+ T cells and in CD8αα+ dendritic cells.
Journal of leukocyte biology
Sakaguchi S,Hombauer M,Hassan H,Tanaka H,Yasmin N,Naoe Y,Bilic I,Moser MA,Hainberger D,Mayer H,Seiser C,Bergthaler A,Taniuchi I,Ellmeier W
17-0114 was used in Flow cytometry/Cell sorting to identify a novel Cd8 enhancer that directs expression in CD44(hi)CD62L(+) CD8(+) T cells, including innate-like and antigen-specific effector/memory CD8(+) T cells and in CD8αα(+) DCs.
Wed Apr 01 00:00:00 EDT 2015
Monitoring and cell-specific deletion of C5aR1 using a novel floxed GFP-C5aR1 reporter knock-in mouse.
Journal of immunology (Baltimore, Md. : 1950)
Karsten CM,Laumonnier Y,Eurich B,Ender F,Bröker K,Roy S,Czabanska A,Vollbrandt T,Figge J,Köhl J
17-0114 was used in Flow cytometry/Cell sorting to study cell-specific deletion of C5aR1 using a GFP-reporter knock-in mouse model.
Sun Feb 15 00:00:00 EST 2015
Cornea-infiltrating and lymph node dendritic cells contribute to CD4+ T cell expansion after herpes simplex virus-1 ocular infection.
Journal of immunology (Baltimore, Md. : 1950)
Buela KA,Hendricks RL
17-0114 was used in Flow cytometry/Cell sorting to determine the contribution of cornea resident, cornea-infiltrating, and DLN resident dendritic cells (DC) to CD4(+) T cell expansion in DLNs and restimulation in corneas.
Thu Jan 01 00:00:00 EST 2015
In vivo capture and label-free detection of early metastatic cells.
Nature communications
Azarin SM,Yi J,Gower RM,Aguado BA,Sullivan ME,Goodman AG,Jiang EJ,Rao SS,Ren Y,Tucker SL,Backman V,Jeruss JS,Shea LD
17-0114 was used in Flow cytometry/Cell sorting to develop an in vivo capture and label-free detection method for early metastasis, showing potential to identify metastasis in patients at risk of recurrence.
Tue Sep 08 00:00:00 EDT 2015
Secretome identification of immune cell factors mediating metastatic cell homing.
Scientific reports
Aguado BA,Wu JJ,Azarin SM,Nanavati D,Rao SS,Bushnell GG,Medicherla CB,Shea LD
17-0114 was used in Flow cytometry/Cell sorting to identify paracrine interactions between immune cells and metastatic cells as novel mediators of homing.
Fri Dec 04 00:00:00 EST 2015
Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases.
Nature communications
Kanno A,Tanimura N,Ishizaki M,Ohko K,Motoi Y,Onji M,Fukui R,Shimozato T,Yamamoto K,Shibata T,Sano S,Sugahara-Tobinai A,Takai T,Ohto U,Shimizu T,Saitoh S,Miyake K
17-0114 was used in Flow cytometry/Cell sorting to show that Toll-like receptor 7 (TLR7) is present on the cell surface of immune cells and that TLR7 responses can be inhibited by an anti-TLR7 antibody.
Wed Feb 04 00:00:00 EST 2015
Role of T-cell reconstitution in HIV-1 antiretroviral therapy-induced bone loss.
Nature communications
Ofotokun I,Titanji K,Vikulina T,Roser-Page S,Yamaguchi M,Zayzafoon M,Williams IR,Weitzmann MN
17-0114 was used in Flow cytometry/Cell sorting to suggest T-cell repopulation and/or immune reconstitution as putative mechanisms for bone loss following ART initiation.
Tue Sep 22 00:00:00 EDT 2015
Critical role for syndecan-4 in dendritic cell migration during development of allergic airway inflammation.
Nature communications
Polte T,Petzold S,Bertrand J,Schütze N,Hinz D,Simon JC,Lehmann I,Echtermeyer F,Pap T,Averbeck M
17-0114 was used in Flow cytometry/Cell sorting to demonstrate that SDC4 plays an important role in asthma induction and indicate SDC4 as a possible target for therapeutic intervention in this disease.
Mon Jul 13 00:00:00 EDT 2015
Oxidation by neutrophils-derived HOCl increases immunogenicity of proteins by converting them into ligands of several endocytic receptors involved in antigen uptake by dendritic cells and macrophages.
PloS one
Biedroń R,Konopiński MK,Marcinkiewicz J,Józefowski S
17-0114 was used in Flow cytometry/Cell sorting to suggest that a mechanism involving neutrophil-derived hypochlorous acid may enable the immune system to detect pathogens unrecognisable by pattern recognition receptors.
Tue Apr 05 00:00:00 EDT 2016
Depletion of alveolar macrophages in CD11c diphtheria toxin receptor mice produces an inflammatory response.
Immunity, inflammation and disease
Roberts LM,Ledvina HE,Tuladhar S,Rana D,Steele SP,Sempowski GD,Frelinger JA
17-0114 was used in Flow cytometry/Cell sorting to reveal the myriad of molecular side effects observable after diphtheria toxin-mediated depletion of alveolar macrophages.
Mon Jun 01 00:00:00 EDT 2015
An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action.
Nature medicine
Gibbs J,Ince L,Matthews L,Mei J,Bell T,Yang N,Saer B,Begley N,Poolman T,Pariollaud M,Farrow S,DeMayo F,Hussell T,Worthen GS,Ray D,Loudon A
17-0114 was used in Flow cytometry/Cell sorting to study the regulatory mechanism linking the circadian clock and glucocorticoid hormones, to control time-of-day variation and the magnitude of pulmonary inflammation.
Fri Aug 01 00:00:00 EDT 2014
Agonistic induction of PPARγ reverses cigarette smoke-induced emphysema.
The Journal of clinical investigation
Shan M,You R,Yuan X,Frazier MV,Porter P,Seryshev A,Hong JS,Song LZ,Zhang Y,Hilsenbeck S,Whitehead L,Zarinkamar N,Perusich S,Corry DB,Kheradmand F
17-0114 was used in Flow cytometry/Cell sorting to reveal a proinflammatory pathway, in which reduced PPARγ activity promotes emphysema.
Sat Mar 01 00:00:00 EST 2014
A generally applicable translational strategy identifies S100A4 as a candidate gene in allergy.
Science translational medicine
Bruhn S,Fang Y,Barrenäs F,Gustafsson M,Zhang H,Konstantinell A,Krönke A,Sönnichsen B,Bresnick A,Dulyaninova N,Wang H,Zhao Y,Klingelhöfer J,Ambartsumian N,Beck MK,Nestor C,Bona E,Xiang Z,Benson M
17-0114 was used in Flow cytometry/Cell sorting to demonstrate a novel strategy for the identification of diagnostic markers and therapeutic candidate genes in common diseases.
Wed Jan 08 00:00:00 EST 2014
Targeting intestinal inflammation with CD98 siRNA/PEI-loaded nanoparticles.
Molecular therapy : the journal of the American Society of Gene Therapy
Laroui H,Geem D,Xiao B,Viennois E,Rakhya P,Denning T,Merlin D
17-0114 was used in Flow cytometry/Cell sorting to show that CD98 was effectively down-regulated in the intestinal epithelial cells and intestinal macrophages of treated mice.
Wed Jan 01 00:00:00 EST 2014
Myeloid cell-specific ATP-binding cassette transporter A1 deletion has minimal impact on atherogenesis in atherogenic diet-fed low-density lipoprotein receptor knockout mice.
Arteriosclerosis, thrombosis, and vascular biology
Bi X,Zhu X,Gao C,Shewale S,Cao Q,Liu M,Boudyguina E,Gebre AK,Wilson MD,Brown AL,Parks JS
17-0114 was used in Flow cytometry/Cell sorting to assess the atherosclerotic impact of myeloid cell ATP-binding cassette transporter A1.
Mon Sep 01 00:00:00 EDT 2014
Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation.
eLife
Baptista AP,Roozendaal R,Reijmers RM,Koning JJ,Unger WW,Greuter M,Keuning ED,Molenaar R,Goverse G,Sneeboer MM,den Haan JM,Boes M,Mebius RE
17-0114 was used in Flow cytometry/Cell sorting to investigate the role of MHC-II in lymph node stromal cells, showing that stromal cells constrain immunity through MHC-II expression.
Wed Nov 19 00:00:00 EST 2014
CX3CR1⁺ cells facilitate the activation of CD4 T cells in the colonic lamina propria during antigen-driven colitis.
Mucosal immunology
Rossini V,Zhurina D,Radulovic K,Manta C,Walther P,Riedel CU,Niess JH
17-0114 was used in Flow cytometry/Cell sorting to study immune cell communication during the development of transfer colitis.
Thu May 01 00:00:00 EDT 2014
The triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia.
PLoS pathogens
Sharif O,Gawish R,Warszawska JM,Martins R,Lakovits K,Hladik A,Doninger B,Brunner J,Korosec A,Schwarzenbacher RE,Berg T,Kralovics R,Colinge J,Mesteri I,Gilfillan S,Salmaggi A,Verschoor A,Colonna M,Knapp S
17-0114 was used in Flow cytometry/Cell sorting to investigate the role of TREM-2 in respiratory tract infections.
Sun Jun 01 00:00:00 EDT 2014
Targeted GAS6 delivery to the CNS protects axons from damage during experimental autoimmune encephalomyelitis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gruber RC,Ray AK,Johndrow CT,Guzik H,Burek D,de Frutos PG,Shafit-Zagardo B
17-0114 was used in Flow cytometry/Cell sorting to test whether intracerebroventricular delivery of growth arrest-specific protein 6 during EAE in mice improves the clinical course of disease.
Wed Dec 03 00:00:00 EST 2014
Dietary gluten increases natural killer cell cytotoxicity and cytokine secretion.
European journal of immunology
Larsen J,Dall M,Antvorskov JC,Weile C,Engkilde K,Josefsen K,Buschard K
17-0114 was used in Flow cytometry/Cell sorting to study the in vitro and in vivo effects of gluten on natural killer cells.
Wed Oct 01 00:00:00 EDT 2014
VB-201, an oxidized phospholipid small molecule, inhibits CD14- and Toll-like receptor-2-dependent innate cell activation and constrains atherosclerosis.
Clinical and experimental immunology
Mendel I,Feige E,Yacov N,Salem Y,Levi I,Propheta-Meiran O,Shoham A,Ishai E,George J,Harats D,Breitbart E
17-0114-82 was used in In vitro experiments to demonstrate that VB-201 inhibits Toll-like receptor (TLR) signalling restricted to TLR-2 and TLR-4 in human and mouse monocytes and dendritic cells.
Wed Jan 01 00:00:00 EST 2014
Identification of early interactions between Francisella and the host.
Infection and immunity
Roberts LM,Tuladhar S,Steele SP,Riebe KJ,Chen CJ,Cumming RI,Seay S,Frothingham R,Sempowski GD,Kawula TH,Frelinger JA
17-0114 was used in Flow cytometry/Cell sorting to identify the first cells to respond to infections of various pathogens in the lungs of mice.
Sun Jun 01 00:00:00 EDT 2014
Systemic sensitization with the protein allergen ovalbumin augments local sensitization in atopic dermatitis.
Journal of inflammation research
Yoo J,Manicone AM,McGuire JK,Wang Y,Parks WC
17-0114 was used in Flow cytometry/Cell sorting to reveal a mouse model of atopic dermatitis that reveals novel insights into the pathogenesis of this complex disease.
Thu Mar 27 00:00:00 EDT 2014
Fusion of antigen to a dendritic cell targeting chemokine combined with adjuvant yields a malaria DNA vaccine with enhanced protective capabilities.
PloS one
Luo K,Zhang H,Zavala F,Biragyn A,Espinosa DA,Markham RB
17-0114 was used in Flow cytometry/Cell sorting to investigate methods to provide immunity to malaria challenge.
Tue Jan 13 00:00:00 EST 2015
Omega-1 knockdown in Schistosoma mansoni eggs by lentivirus transduction reduces granuloma size in vivo.
Nature communications
Hagen J,Young ND,Every AL,Pagel CN,Schnoeller C,Scheerlinck JP,Gasser RB,Kalinna BH
17-0114 was used in Flow cytometry/Cell sorting to investigate selected protein-encoding genes of S. mansoni implicated in the disease process of schistosomiasis.
Mon Nov 17 00:00:00 EST 2014
Phospholipase cε, an effector of ras and rap small GTPases, is required for airway inflammatory response in a mouse model of bronchial asthma.
PloS one
Nagano T,Edamatsu H,Kobayashi K,Takenaka N,Yamamoto M,Sasaki N,Nishimura Y,Kataoka T
17-0114 was used in Flow cytometry/Cell sorting to demonstrate that PLCε is important in bronchial asthma pathogenesis through upregulating inflammatory cytokine production by bronchial epithelial cells.
Wed Jun 10 00:00:00 EDT 2015
mRNA-based vaccines synergize with radiation therapy to eradicate established tumors.
Radiation oncology (London, England)
Fotin-Mleczek M,Zanzinger K,Heidenreich R,Lorenz C,Kowalczyk A,Kallen KJ,Huber SM
17-0114 was used in Flow cytometry/Cell sorting to investigate how mRNA-based vaccines interact with radiation therapy in treating established tumours.
Fri Aug 15 00:00:00 EDT 2014
CX3CR1-dependent renal macrophage survival promotes Candida control and host survival.
The Journal of clinical investigation
Lionakis MS,Swamydas M,Fischer BG,Plantinga TS,Johnson MD,Jaeger M,Green NM,Masedunskas A,Weigert R,Mikelis C,Wan W,Lee CC,Lim JK,Rivollier A,Yang JC,Laird GM,Wheeler RT,Alexander BD,Perfect JR,Gao JL,Kullberg BJ,Netea MG,Murphy PM
17-0114 was used in Flow cytometry/Cell sorting to elucidate the roles of innate immune cells in the pathogenesis of C. albicans.
Sun Dec 01 00:00:00 EST 2013
Host immunity contributes to the anti-melanoma activity of BRAF inhibitors.
The Journal of clinical investigation
Knight DA,Ngiow SF,Li M,Parmenter T,Mok S,Cass A,Haynes NM,Kinross K,Yagita H,Koya RC,Graeber TG,Ribas A,McArthur GA,Smyth MJ
17-0114 was used in Flow cytometry/Cell sorting to investigate the contribution of host immunity to the anti-melanoma activity of BRAF inhibitors.
Fri Mar 01 00:00:00 EST 2013
The Nlrp3 inflammasome regulates acute graft-versus-host disease.
The Journal of experimental medicine
Jankovic D,Ganesan J,Bscheider M,Stickel N,Weber FC,Guarda G,Follo M,Pfeifer D,Tardivel A,Ludigs K,Bouazzaoui A,Kerl K,Fischer JC,Haas T,Schmitt-Gräff A,Manoharan A,Müller L,Finke J,Martin SF,Gorka O,Peschel C,Ruland J,Idzko M,Duyster J,Holler E,French LE,Poeck H,Contassot E,Zeiser R
17-0114 was used in Flow cytometry/Cell sorting to study the establishment and role of the Nlrp3 inflammasome in acute graft-versus-host disease.
Mon Sep 23 00:00:00 EDT 2013
MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.
The Journal of experimental medicine
Molnarfi N,Schulze-Topphoff U,Weber MS,Patarroyo JC,Prod'homme T,Varrin-Doyer M,Shetty A,Linington C,Slavin AJ,Hidalgo J,Jenne DE,Wekerle H,Sobel RA,Bernard CC,Shlomchik MJ,Zamvil SS
17-0114 was used in Flow cytometry/Cell sorting to investigate the contribution of B cells to antigen presentation and pathogenic T cell activation in the multiple sclerosis model experimental autoimmune encephalomyelitis.
Mon Dec 16 00:00:00 EST 2013
A novel murine model of rhinoscleroma identifies Mikulicz cells, the disease signature, as IL-10 dependent derivatives of inflammatory monocytes.
EMBO molecular medicine
Fevre C,Almeida AS,Taront S,Pedron T,Huerre M,Prevost MC,Kieusseian A,Cumano A,Brisse S,Sansonetti PJ,Tournebize R
17-0114 was used in Flow cytometry/Cell sorting to characterise a murine model recapitulating the formation of Mikulicz cells in lungs to assess the cellular origins of Mikulicz cells during K. rhinoscleromatis infection.
Mon Apr 01 00:00:00 EDT 2013
The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis.
The EMBO journal
Petersen B,Wolf M,Austermann J,van Lent P,Foell D,Ahlmann M,Kupas V,Loser K,Sorg C,Roth J,Vogl T
17-0114 was used in Magnetic cell separation to study the role of TLR-4 ligand Mrp8/14 in inflammation and adaptive immunity.
Wed Jan 09 00:00:00 EST 2013
Mesenchymal stem cells are mobilized from the bone marrow during inflammation.
Frontiers in immunology
Koning JJ,Kooij G,de Vries HE,Nolte MA,Mebius RE
17-0114 was used in Flow cytometry/Cell sorting to analyse mesenchymal stem- and T-cell migration during experimental allergic encephalomyelitis.
Wed Mar 06 00:00:00 EST 2013
IL-27 receptor signalling restricts the formation of pathogenic, terminally differentiated Th1 cells during malaria infection by repressing IL-12 dependent signals.
PLoS pathogens
Villegas-Mendez A,de Souza JB,Lavelle SW,Gwyer Findlay E,Shaw TN,van Rooijen N,Saris CJ,Hunter CA,Riley EM,Couper KN
17-0114-82 was used in Flow Cytometry to investigate the molecular basis of IL-27 receptor/ WSX-1-mediated regulation of Th1 responses in vivo during malaria infection.
Fri Jan 10 00:00:00 EST 2014
CD22 is required for protection against West Nile virus Infection.
Journal of virology
Ma DY,Suthar MS,Kasahara S,Gale M,Clark EA
17-0114 was used in Flow cytometry/Cell sorting to elucidate the immunological requirements for an antibody response following West Nile virus infection.
Fri Mar 01 00:00:00 EST 2013
Galectin-3 negatively regulates dendritic cell production of IL-23/IL-17-axis cytokines in infection by Histoplasma capsulatum.
Journal of immunology (Baltimore, Md. : 1950)
Wu SY,Yu JS,Liu FT,Miaw SC,Wu-Hsieh BA
17-0114 was used in Flow cytometry/Cell sorting to investigate the cytokine immunoregulatory functions of gal3 in response to infection.
Mon Apr 01 00:00:00 EDT 2013
Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice.
Journal of immunology (Baltimore, Md. : 1950)
Suzukawa M,Miller M,Rosenthal P,Cho JY,Doherty TA,Varki A,Broide D
17-0114 was used in Flow cytometry/Cell sorting to study the regulated murine expression of Siglec-F ligand in immune and lung airway epithelial cells.
Sat Jun 15 00:00:00 EDT 2013
Thymic damage, impaired negative selection, and development of chronic graft-versus-host disease caused by donor CD4+ and CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wu T,Young JS,Johnston H,Ni X,Deng R,Racine J,Wang M,Wang A,Todorov I,Wang J,Zeng D
17-0114 was used in Flow cytometry/Cell sorting to evaluate the contribution of T cells to the induction of chronic graft-versus-host disease.
Mon Jul 01 00:00:00 EDT 2013
Hepatic stellate cells preferentially induce Foxp3+ regulatory T cells by production of retinoic acid.
Journal of immunology (Baltimore, Md. : 1950)
Dunham RM,Thapa M,Velazquez VM,Elrod EJ,Denning TL,Pulendran B,Grakoui A
17-0114 was used in Flow cytometry/Cell sorting to demonstrate a potential Treg enrichment role for hepatic stellate cells, supporting the tolerogenic nature of the liver.
Fri Mar 01 00:00:00 EST 2013
Modulation of inflammasome-mediated pulmonary immune activation by type I IFNs protects bone marrow homeostasis during systemic responses to Pneumocystis lung infection.
Journal of immunology (Baltimore, Md. : 1950)
Searles S,Gauss K,Wilkison M,Hoyt TR,Dobrinen E,Meissner N
17-0114 was used in Flow cytometry/Cell sorting to study how the absence of type I IFN signalling during Pneumocystis lung infection may result in deregulation of inflammasome-mediated pulmonary immune activation.
Tue Oct 01 00:00:00 EDT 2013
AID-expressing germinal center B cells cluster normally within lymph node follicles in the absence of FDC-M1+ CD35+ follicular dendritic cells but dissipate prematurely.
Journal of immunology (Baltimore, Md. : 1950)
Boulianne B,Le MX,Ward LA,Meng L,Haddad D,Li C,Martin A,Gommerman JL
17-0114 was used in Flow cytometry/Cell sorting to provide a spatial-temporal analysis of Ag-specific B cell activation and AID expression in the context of a peripheral lymph node that lacks FDC-M1(+) CD35(+) FDC and other LT-sensitive cell types.
Fri Nov 01 00:00:00 EDT 2013
SWAP-70 restricts spontaneous maturation of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Ocaña-Morgner C,Götz A,Wahren C,Jessberger R
17-0114 was used in Flow cytometry/Cell sorting to study the mechanisms and signals that produce mature DCs.
Sat Jun 01 00:00:00 EDT 2013
SWAP-70 restricts spontaneous maturation of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Ocaña-Morgner C,Götz A,Wahren C,Jessberger R
17-0114 was used in Flow cytometry/Cell sorting to study the mechanisms and signals that produce mature DCs.
Sat Jun 01 00:00:00 EDT 2013
Peptidoglycan recognition protein 1 enhances experimental asthma by promoting Th2 and Th17 and limiting regulatory T cell and plasmacytoid dendritic cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Park SY,Jing X,Gupta D,Dziarski R
17-0114 was used in Flow cytometry/Cell sorting to demonstrate the proinflammatory effect of peptidoglycan recognition protein (Pglyrp)1 during the development of allergic asthma.
Mon Apr 01 00:00:00 EDT 2013
S-layer protein mediates the stimulatory effect of Lactobacillus helveticus MIMLh5 on innate immunity.
Applied and environmental microbiology
Taverniti V,Stuknyte M,Minuzzo M,Arioli S,De Noni I,Scabiosi C,Cordova ZM,Junttila I,Hämäläinen S,Turpeinen H,Mora D,Karp M,Pesu M,Guglielmetti S
17-0114 was used in Flow cytometry/Cell sorting to demonstrate the potential for L. helveticus surface-layer protein A to induce the host's defences against infections.
Fri Feb 01 00:00:00 EST 2013
A method for high purity sorting of rare cell subsets applied to TDC.
Journal of immunological methods
Kuka M,Ashwell JD
17-0114 was used in Flow cytometry/Cell sorting to describe a customised gating strategy and a sorting protocol for the isolation of T(DC).
Tue Dec 31 00:00:00 EST 2013
Migration of CD11b+ accessory cells during murine lung regeneration.
Stem cell research
Chamoto K,Gibney BC,Lee GS,Ackermann M,Konerding MA,Tsuda A,Mentzer SJ
17-0114 was used in Flow cytometry/Cell sorting to characterise the factors contributing to neoalveolarization within 21 days of pneumonectomy.
Wed May 01 00:00:00 EDT 2013
G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising CD8+ T cell immune responses.
Journal of hematology & oncology
Rubinstein MP,Salem ML,Doedens AL,Moore CJ,Chiuzan C,Rivell GL,Cole DJ,Goldrath AW
17-0114 was used in Flow cytometry/Cell sorting to evaluate whether the biological activity of G-CSF can be improved by pre-association with anti-G-CSF monoclonal antibodies prior to injection.
Tue Oct 01 00:00:00 EDT 2013
Interleukin-27 receptor limits atherosclerosis in Ldlr-/- mice.
Circulation research
Koltsova EK,Kim G,Lloyd KM,Saris CJ,von Vietinghoff S,Kronenberg M,Ley K
17-0114 was used in Flow cytometry/Cell sorting to establish a novel role for IL-27 receptor signalling in limiting arterial inflammation and atherosclerosis.
Fri Oct 26 00:00:00 EDT 2012
Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis.
The Journal of clinical investigation
Koltsova EK,Garcia Z,Chodaczek G,Landau M,McArdle S,Scott SR,von Vietinghoff S,Galkina E,Miller YI,Acton ST,Ley K
17-0114 was used in Flow cytometry/Cell sorting to conclude that antigen presentation to CD4+ cells causes local T cell activation and the production of proinflammatory cytokines.
Sat Sep 01 00:00:00 EDT 2012
Cigarette smoke induction of osteopontin (SPP1) mediates T(H)17 inflammation in human and experimental emphysema.
Science translational medicine
Shan M,Yuan X,Song LZ,Roberts L,Zarinkamar N,Seryshev A,Zhang Y,Hilsenbeck S,Chang SH,Dong C,Corry DB,Kheradmand F
17-0114 was used in Flow cytometry/Cell sorting to show that cigarette smoke increases the expression of IL-17A in both CD4+ and γδ T cells from mouse lung.
Wed Jan 18 00:00:00 EST 2012
IL-33 induces innate lymphoid cell-mediated airway inflammation by activating mammalian target of rapamycin.
The Journal of allergy and clinical immunology
Salmond RJ,Mirchandani AS,Besnard AG,Bain CC,Thomson NC,Liew FY
17-0114 was used in Flow cytometry/Cell sorting to investigate the role of mTOR signalling in the activation of TH2, ILC and IL-33 inflammation responses.
Thu Nov 01 00:00:00 EDT 2012
Cross-circulation and cell distribution kinetics in parabiotic mice.
Journal of cellular physiology
Gibney BC,Chamoto K,Lee GS,Simpson DC,Miele LF,Tsuda A,Konerding MA,Wagers A,Mentzer SJ
17-0114 was used in Flow cytometry/Cell sorting to conclude that parabiosis can provide important insights into defining tissue distribution, residence times, and recirculating pools.
Wed Feb 01 00:00:00 EST 2012
Conventional dendritic cells require IRAP-Rab14 endosomes for efficient cross-presentation.
Journal of immunology (Baltimore, Md. : 1950)
Weimershaus M,Maschalidi S,Sepulveda F,Manoury B,van Endert P,Saveanu L
17-0114 was used in Flow cytometry/Cell sorting to examine the role of insulin-responsive aminopeptidase in steady-state dendritic cell subpopulations.
Wed Feb 15 00:00:00 EST 2012
Type 2 innate immunity in helminth infection is induced redundantly and acts autonomously following CD11c(+) cell depletion.
Infection and immunity
Smith KA,Harcus Y,Garbi N,Hämmerling GJ,MacDonald AS,Maizels RM
17-0114 was used in Flow cytometry/Cell sorting to investigate the type 2 response to intestinal nematode parasites, showing that it is induced redundantly and acts autonomously following CD11c(+) cell depletion.
Mon Oct 01 00:00:00 EDT 2012
MyD88-dependent recruitment of monocytes and dendritic cells required for protection from pulmonary Burkholderia mallei infection.
Infection and immunity
Goodyear A,Troyer R,Bielefeldt-Ohmann H,Dow S
17-0114 was used in Flow cytometry/Cell sorting to find that MyD88-/- mice were highly susceptible to pulmonary challenge with B. mallei and had significantly short survival times, increased bacterial burdens, and severe organ pathology compared to wild-type mice.
Sun Jan 01 00:00:00 EST 2012
CD36 modulates proinflammatory cytokine responses to Plasmodium falciparum glycosylphosphatidylinositols and merozoites by dendritic cells.
Parasite immunology
Kumar S,Gowda NM,Wu X,Gowda RN,Gowda DC
17-0114 was used in Flow cytometry/Cell sorting to demonstrate that CD36 modulates the activity of Plasmodium falciparum merozoites.
Sun Jul 01 00:00:00 EDT 2012
The MSHA strain of Pseudomonas aeruginosa activated TLR pathway and enhanced HIV-1 DNA vaccine immunoreactivity.
PloS one
Hou J,Liu Y,Liu Y,Shao Y
17-0114 was used in Flow cytometry/Cell sorting to demonstrate the utility of mannose-sensitive hemagglutination pilus Pseudomonas aeruginosa as an adjuvant to a DNA vaccine.
Wed Apr 03 00:00:00 EDT 2013
A critical role for SOCS3 in innate resistance to Toxoplasma gondii.
Cell host & microbe
Whitmarsh RJ,Gray CM,Gregg B,Christian DA,May MJ,Murray PJ,Hunter CA
17-0114 was used in Flow cytometry/Cell sorting to study the role of SOCS3 in suppressing IL-6 signalling during immune responses to T. gondii infection.
Thu Sep 15 00:00:00 EDT 2011
CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice.
The Journal of clinical investigation
Medina-Contreras O,Geem D,Laur O,Williams IR,Lira SA,Nusrat A,Parkos CA,Denning TL
17-0114 was used in Flow cytometry/Cell sorting to investigate the relative contributions of different APC populations in IBD, showing that CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses.
Thu Dec 01 00:00:00 EST 2011
Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice.
The Journal of clinical investigation
Hammerschmidt SI,Friedrichsen M,Boelter J,Lyszkiewicz M,Kremmer E,Pabst O,Förster R
17-0114 was used in Flow cytometry/Cell sorting to investigate the effectiveness of retinoic acid-assisted subcutaneous immunisation as a novel approach to vaccination against enteropathogens.
Mon Aug 01 00:00:00 EDT 2011
Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice.
The Journal of clinical investigation
Woller N,Knocke S,Mundt B,Gürlevik E,Strüver N,Kloos A,Boozari B,Schache P,Manns MP,Malek NP,Sparwasser T,Zender L,Wirth TC,Kubicka S,Kühnel F
17-0114 was used in Magnetic cell separation to highlight viruses as attractive tools for eliciting effective antitumour responses upon DC vaccination.
Fri Jul 01 00:00:00 EDT 2011
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine
Stock A,Booth S,Cerundolo V
17-0114 was used in Flow cytometry/Cell sorting to study how PGE2 stimulates the expression of the inducible cyclic AMP early repressor, which appears to directly inhibit RALDH expression in DCs.
Mon Apr 11 00:00:00 EDT 2011
Morphological plasticity promotes resistance to phagocyte killing of uropathogenic Escherichia coli.
Microbes and infection
Horvath DJ,Li B,Casper T,Partida-Sanchez S,Hunstad DA,Hultgren SJ,Justice SS
17-0114 was used in Flow cytometry/Cell sorting to demonstrate that SulA-mediated filamentation in UPEC provides a selective advantage in evading phagocytic killing, and represents a distinct class of mechanism for subverting host immunity.
Sun May 01 00:00:00 EDT 2011
Eosinophils contribute to IL-4 production and shape the T-helper cytokine profile and inflammatory response in pulmonary cryptococcosis.
The American journal of pathology
Piehler D,Stenzel W,Grahnert A,Held J,Richter L,Köhler G,Richter T,Eschke M,Alber G,Müller U
17-0114 was used in Flow cytometry/Cell sorting to investigate the time course of IL-4 production and its innate cellular source in mice infected intranasally with Cryptococcus neoformans.
Mon Aug 01 00:00:00 EDT 2011
Identification of a novel antigen cross-presenting cell type in spleen.
Journal of cellular and molecular medicine
Tan JK,Quah BJ,Griffiths KL,Periasamy P,Hey YY,O'Neill HC
17-0114 was used in Flow cytometry/Cell sorting to study a novel DC type produced by in vitro haematopoiesis which has distinct antigen-presenting potential and reflects a DC subset present also in vivo in spleen.
Sun May 01 00:00:00 EDT 2011
Evaluation of macrophage plasticity in brown and white adipose tissue.
Cellular immunology
Ortega MT,Xie L,Mora S,Chapes SK
17-0114 was used in Flow cytometry/Cell sorting to investigate the impact of white adipose tissue, brown adipose tissue and in vitro cultured adipocytes on C2D macrophage cell plasticity in different microenvironments.
Fri Dec 09 00:00:00 EST 2011
Plasmodium falciparum: differential merozoite dose requirements for maximal production of various inflammatory cytokines.
Experimental parasitology
Wu X,Gowda NM,Gowda DC
17-0114 was used in Flow cytometry/Cell sorting to investigate differential merozoite dose requirements for maximal production of various inflammatory cytokines in Plasmodium falciparum.
Sat Jan 01 00:00:00 EST 2011
Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tract.
mBio
Parker D,Martin FJ,Soong G,Harfenist BS,Aguilar JL,Ratner AJ,Fitzgerald KA,Schindler C,Prince A
17-0114 was used in Flow cytometry/Cell sorting to show how the extracellular pathogen Streptococcus pneumoniae activates type I interferon signalling in the murine lung, and the role of this response in bacterial clearance.
Thu Oct 27 00:00:00 EDT 2011
PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin.
Nature communications
Frateschi S,Camerer E,Crisante G,Rieser S,Membrez M,Charles RP,Beermann F,Stehle JC,Breiden B,Sandhoff K,Rotman S,Haftek M,Wilson A,Ryser S,Steinhoff M,Coughlin SR,Hummler E
17-0114 was used in Flow cytometry/Cell sorting to study PAR2 as a downstream effector of CAP1/Prss8 in a signalling cascade, potentially providing therapeutic targets for ichthyoses, pruritus and inflammatory skin diseases.
Tue Jan 18 00:00:00 EST 2011
Production of IFN-β during Listeria monocytogenes infection is restricted to monocyte/macrophage lineage.
PloS one
Solodova E,Jablonska J,Weiss S,Lienenklaus S
17-0114 was used in Flow cytometry/Cell sorting to investigate which cells are responsible for IFN-β expression after infection with Listeria monocytogenes.
Mon Apr 11 00:00:00 EDT 2011
Excess circulating alternatively activated myeloid (M2) cells accelerate ALS progression while inhibiting experimental autoimmune encephalomyelitis.
PloS one
Vaknin I,Kunis G,Miller O,Butovsky O,Bukshpan S,Beers DR,Henkel JS,Yoles E,Appel SH,Schwartz M
17-0114 was used in Flow cytometry/Cell sorting to establish circulating MDSCs as a novel target for therapeutic intervention in ALS, at least at the early stage.
Mon Mar 26 00:00:00 EDT 2012
Neutrophil-derived CCL3 is essential for the rapid recruitment of dendritic cells to the site of Leishmania major inoculation in resistant mice.
PLoS pathogens
Charmoy M,Brunner-Agten S,Aebischer D,Auderset F,Launois P,Milon G,Proudfoot AE,Tacchini-Cottier F
17-0114 was used in Flow cytometry/Cell sorting to determine that the selective release of neutrophil-secreted chemokines may regulate the development of immune responses to pathogens.
Fri Feb 05 00:00:00 EST 2010
Prophylactic administration of bacterially derived immunomodulators improves the outcome of influenza virus infection in a murine model.
Journal of virology
Norton EB,Clements JD,Voss TG,Cárdenas-Freytag L
17-0114 was used in Flow cytometry/Cell sorting to investigate the effect of prophylactic immunomodulation on the outcome of viral infection.
Mon Mar 01 00:00:00 EST 2010
Fine-scale staging of T cell lineage commitment in adult mouse thymus.
Journal of immunology (Baltimore, Md. : 1950)
Yui MA,Feng N,Rothenberg EV
17-0114 was used in Flow cytometry/Cell sorting to determine the gene regulatory changes that accompany commitment in adult wild-type double-negative adult thymocytes.
Thu Jul 01 00:00:00 EDT 2010
Synergistic antitumor effects of regulatory T cell blockade combined with pemetrexed in murine malignant mesothelioma.
Journal of immunology (Baltimore, Md. : 1950)
Anraku M,Tagawa T,Wu L,Yun Z,Keshavjee S,Zhang L,Johnston MR,de Perrot M
17-0114 was used in Flow cytometry/Cell sorting to evaluate the potential of a combined Treg blockade-permetrexed anti-tumour treatment.
Thu Jul 15 00:00:00 EDT 2010
Antigen-specific immunity and cross-priming by epithelial ovarian carcinoma-induced CD11b(+)Gr-1(+) cells.
Journal of immunology (Baltimore, Md. : 1950)
Tomihara K,Guo M,Shin T,Sun X,Ludwig SM,Brumlik MJ,Zhang B,Curiel TJ,Shin T
17-0114 was used in Flow cytometry/Cell sorting to investigate CD11b(+)Gr-1(+) cells found in epithelial ovarian cancer-bearing mice, which are induced by ovarian cancer cells and undergo antigen-specific immunity and cross-priming.
Tue Jun 01 00:00:00 EDT 2010
Chemoimmunotherapy reduces the progression of multiple myeloma in a mouse model.
Cancer prevention research (Philadelphia, Pa.)
Sharabi A,Laronne-Bar-On A,Meshorer A,Haran-Ghera N
17-0114 was used in Flow cytometry/Cell sorting to determine the effects, and their modes of action, of CYC treatment on MM progression.
Fri Oct 01 00:00:00 EDT 2010
Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice.
The Journal of clinical investigation
Bedoret D,Wallemacq H,Marichal T,Desmet C,Quesada Calvo F,Henry E,Closset R,Dewals B,Thielen C,Gustin P,de Leval L,Van Rooijen N,Le Moine A,Vanderplasschen A,Cataldo D,Drion PV,Moser M,Lekeux P,Bureau F
17-0114 was used in Flow cytometry/Cell sorting to reveal a crucial role for IMs in maintaining immune homeostasis in the respiratory tract.
Tue Dec 01 00:00:00 EST 2009
Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection.
The Journal of experimental medicine
Lee HK,Zamora M,Linehan MM,Iijima N,Gonzalez D,Haberman A,Iwasaki A
17-0114 was used in Flow cytometry/Cell sorting to to study the differential roles of migratory and resident DC's in T cell priming after mucosal or skin HSV-1 infection.
Mon Feb 16 00:00:00 EST 2009
Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses.
Journal of immunology (Baltimore, Md. : 1950)
Walsh KP,Brady MT,Finlay CM,Boon L,Mills KH
17-0114 was used in Flow cytometry/Cell sorting to provide evidence that parasites can exert bystander immunosuppression of pathogenic T cells that mediate autoimmune diseases.
Sat Aug 01 00:00:00 EDT 2009
Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70.
Journal of immunology (Baltimore, Md. : 1950)
Zietara N,Łyszkiewicz M,Gekara N,Puchałka J,Dos Santos VA,Hunt CR,Pandita TK,Lienenklaus S,Weiss S
17-0114 was used in Flow cytometry/Cell sorting to investigate the role of low level production of IFN, showing that its absence impairs antigen presentation capacity of splenic dendritic cells.
Wed Jul 15 00:00:00 EDT 2009
GITR Blockade Facilitates Treg Mediated Allograft Survival.
Transplantation
Sonawane SB,Kim JI,Lee MK,Lee SH,Duff PE,Moore DJ,Lian MM,Deng S,Choi Y,Yeh H,Caton AJ,Markmann JF
17-0114 was used in Flow cytometry/Cell sorting to study how inflammation and other innate immune signals may activate antigen presenting cells to up-regulate GITR.
Fri Nov 27 00:00:00 EST 2009
Lymphocytes serve as a reservoir for Listeria monocytogenes growth during infection of mice.
Microbial pathogenesis
McElroy DS,Ashley TJ,D'Orazio SE
17-0114 was used in Flow cytometry/Cell sorting to demonstrate that intracellular L. monocytogenes can survive and multiply in vitro in a variety of transformed cell lines of lymphocytic origin.
Wed Apr 01 00:00:00 EDT 2009
Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis.
The Journal of biological chemistry
Turner JD,Langley RS,Johnston KL,Gentil K,Ford L,Wu B,Graham M,Sharpley F,Slatko B,Pearlman E,Taylor MJ
17-0114 was used in Flow cytometry/Cell sorting to investigate the role of Wolbachia lipoprotein in pathogenesis of filariasis, showing that it stimulates innate and adaptive immunity through Toll-like receptors 2 and 6.
Fri Aug 14 00:00:00 EDT 2009
Interaction of Cowpea mosaic virus (CPMV) nanoparticles with antigen presenting cells in vitro and in vivo.
PloS one
Gonzalez MJ,Plummer EM,Rae CS,Manchester M
17-0114 was used in Flow cytometry/Cell sorting to demonstrate that Cowpea mosaic virus is bound and internalised by subsets of several populations of antigen presenting cells.
Mon Nov 23 00:00:00 EST 2009
Some putative prebiotics increase the severity of Salmonella enterica serovar Typhimurium infection in mice.
BMC microbiology
Petersen A,Heegaard PM,Pedersen AL,Andersen JB,Sørensen RB,Frøkiaer H,Lahtinen SJ,Ouwehand AC,Poulsen M,Licht TR
17-0114 was used in Flow cytometry/Cell sorting to examine whether Salmonella infection could be prevented by administration of dietary carbohydrates with different structures and digestibility profiles.
Mon Nov 30 00:00:00 EST 2009
Foxp3+ regulatory T cells promiscuously accept thymic signals critical for their development.
Proceedings of the National Academy of Sciences of the United States of America
Spence PJ,Green EA
17-0114 was used in Flow cytometry/Cell sorting to investigate Foxp3+ Treg development, showing that CD154 is critical during thymic development of Foxp3+ Tregs.
Tue Jan 22 00:00:00 EST 2008
CD24a expression levels discriminate Langerhans cells from dermal dendritic cells in murine skin and lymph nodes.
The Journal of investigative dermatology
Stutte S,Jux B,Esser C,Förster I
17-0114 was used in Flow cytometry/Cell sorting to investigate a novel method to distinguish LCs from dDCs.
Sun Jun 01 00:00:00 EDT 2008
Optimization of methods to study pulmonary dendritic cell migration reveals distinct capacities of DC subsets to acquire soluble versus particulate antigen.
Journal of immunological methods
Jakubzick C,Helft J,Kaplan TJ,Randolph GJ
17-0114 was used in Flow cytometry/Cell sorting to investigate the best approaches to study dendritic cell migration to lung-draining lymph nodes in mice.
Mon Sep 15 00:00:00 EDT 2008
Autocrine/paracrine TGFbeta1 is required for the development of epidermal Langerhans cells.
The Journal of experimental medicine
Kaplan DH,Li MO,Jenison MC,Shlomchik WD,Flavell RA,Shlomchik MJ
17-0114 was used in Flow cytometry/Cell sorting to demonstrate that transforming growth factor beta1 acts directly on Langerhans cells through an autocrine/paracrine loop.
Mon Oct 29 00:00:00 EDT 2007
Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo.
The Journal of experimental medicine
Ohteki T,Tada H,Ishida K,Sato T,Maki C,Yamada T,Hamuro J,Koyasu S
Mon Oct 02 00:00:00 EDT 2006
The existence of CD11c+ sentinel and F4/80+ interstitial dendritic cells in dental pulp and their dynamics and functional properties.
International immunology
Zhang J,Kawashima N,Suda H,Nakano Y,Takano Y,Azuma M
Fri Sep 01 00:00:00 EDT 2006
Discordance in the effects of Yersinia pestis on the dendritic cell functions manifested by induction of maturation and paralysis of migration.
Infection and immunity
Velan B,Bar-Haim E,Zauberman A,Mamroud E,Shafferman A,Cohen S
17-0114 was used in Flow cytometry/Cell sorting to suggest that virulence plasmid-dependent impairment of DC migration is the major mechanism utilized by Y. pestis to subvert DC function.
Wed Nov 01 00:00:00 EST 2006
Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity.
Immunity
Kaplan DH,Jenison MC,Saeland S,Shlomchik WD,Shlomchik MJ
17-0114 was used in Flow cytometry/Cell sorting to demonstrate that contact hypersensitivity is amplified in the absence of epidermal Langerhans cells.
Thu Dec 01 00:00:00 EST 2005
