Invitrogen

CD11c Monoclonal Antibody (N418), PE-Cyanine7, eBioscience™

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FIGURE: 1 / 1

CD11c Antibody (25-0114-82) in Flow

Staining of mouse splenocytes with Anti-Human/Mouse CD45R (B220) FITC (Product # 11-0452-82) and 0.25 µg of Armenian Hamster IgG Isotype Control PE-Cyanine7 (Product # 25-4888-82) (left) or 0.25 µg of Anti-Mouse CD11c PE-Cyanine7 (right). Total viable cells were used for analysis.

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Product Details

25-0114-82

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

View 2 publications 2 publications

Flow Cytometry (Flow)

0.5 µg/test

View 177 publications 177 publications

Product Specifications

Species Reactivity

Mouse

Published species

Human, Mouse

Host/Isotype

Armenian hamster / IgG

Recommended Isotype Control

Armenian Hamster IgG Isotype Control (eBio299Arm), PE-Cyanine7, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

N418

Conjugate

PE-Cyanine7 PE-Cyanine7 PE-Cyanine7

Excitation/Emission Max

569/780 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_469590

Product Specific Information

Description: The N418 monoclonal antibody reacts with mouse CD11c, the integrin alpha X. CD11c non-covalently associates with beta 2 integrin to form the CD11c/CD18 heterodimer. CD11c is expressed by dendritic cells, a subset of Intestinal Intraepithelial Lymphocytes (IEL) and some activated T cells. CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. N418 binds to CD11c on splenic dendritic cells in the T-dependent areas of mouse spleen and precipitates a 150, 90 kDa heterodimer.

Applications Reported: This N418 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This N418 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Light sensitivity: This tandem dye is sensitive to photo-induced oxidation. Please protect this vial and stained samples from light.

Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-822-49) (100 µL of cell sample + 100 µL of IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product # 00-5333-54) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.

Excitation: 488-561 nm; Emission: 775 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

Product References

Immunization against Zika by entrapping live virus in a subcutaneous self-adjuvanting hydrogel.

Nature biomedical engineering

Hao H,Wu S,Lin J,Zheng Z,Zhou Y,Zhang Y,Guo Q,Tian F,Zhao M,Chen Y,Xu X,Hou L,Wang X,Tang R

25-0114-82 was used in Flow cytometry/Cell sorting to show that a subcutaneous vaccine consisting of live Zika virus electrostatically entrapped in a self-adjuvanting hydrogel recruited immune cells at the injection site and provided mice with effective protection against a lethal viral challenge.

Sat Jul 01 00:00:00 EDT 2023

CD4⁺ T cell calibration of antigen-presenting cells optimizes antiviral CD8⁺ T cell immunity.

Nature immunology

Gressier E,Schulte-Schrepping J,Petrov L,Brumhard S,Stubbemann P,Hiller A,Obermayer B,Spitzer J,Kostevc T,Whitney PG,Bachem A,Odainic A,van de Sandt C,Nguyen THO,Ashhurst T,Wilson K,Oates CVL,Gearing LJ,Meischel T,Hochheiser K,Greyer M,Clarke M,Kreutzenbeck M,Gabriel SS,Kastenmüller W,Kurts C,Londrigan SL,Kallies A,Kedzierska K,Hertzog PJ,Latz E,Chen YE,Radford KJ,Chopin M,Schroeder J,Kurth F,Gebhardt T,Sander LE,Sawitzki B,Schultze JL,Schmidt SV,Bedoui S

25-0114-82 was used in Flow cytometry/Cell sorting to describe gradual interferon-α/interferon-β (IFNα/β)-induced transcriptional adaptations that endow APCs with the capacity to rapidly activate the transcriptional regulators p65, IRF1 and FOS after CD4+ T cell-mediated CD40 stimulation.

Thu Jun 01 00:00:00 EDT 2023

A nanoadjuvant that dynamically coordinates innate immune stimuli activation enhances cancer immunotherapy and reduces immune cell exhaustion.

Nature nanotechnology

Jin SM,Yoo YJ,Shin HS,Kim S,Lee SN,Lee CH,Kim H,Kim JE,Bae YS,Hong J,Noh YW,Lim YT

25-0114-82 was used in Flow cytometry/Cell sorting to suggest a kinetically activating nanoadjuvant (K-nanoadjuvant) that can dynamically integrate two waves of innate immune stimuli, resulting in effective antitumour immunity without immune cell exhaustion.

Sat Apr 01 00:00:00 EDT 2023

Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches.

Cell

Guilliams M,Bonnardel J,Haest B,Vanderborght B,Wagner C,Remmerie A,Bujko A,Martens L,Thoné T,Browaeys R,De Ponti FF,Vanneste B,Zwicker C,Svedberg FR,Vanhalewyn T,Gonçalves A,Lippens S,Devriendt B,Cox E,Ferrero G,Wittamer V,Willaert A,Kaptein SJF,Neyts J,Dallmeier K,Geldhof P,Casaert S,Deplancke B,Ten Dijke P,Hoorens A,Vanlander A,Berrevoet F,Van Nieuwenhove Y,Saeys Y,Saelens W,Van Vlierberghe H,Devisscher L,Scott CL

25-0114-82 was used in Flow cytometry/Cell sorting to demonstrate that LAMs are induced by local lipid exposure, leading to their induction in steatotic regions of the murine and human liver, while Kupffer cell development crucially depends on their cross-talk with hepatic stellate cells via the evolutionarily conserved ALK1-BMP9/10 axis.

Thu Jan 20 00:00:00 EST 2022

Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation.

Cell reports

Gros M,Segura E,Rookhuizen DC,Baudon B,Heurtebise-Chrétien S,Burgdorf N,Maurin M,Kapp EA,Simpson RJ,Kozik P,Villadangos JA,Bertrand MJM,Burbage M,Amigorena S

25-0114-82 was used in Flow cytometry/Cell sorting to demonstrate that membrane repair proves crucial in containing antigen export to the cytosol and cross-presentation in cDCs.

Tue Aug 16 00:00:00 EDT 2022

Nanomaterials-Mediated Co-Stimulation of Toll-Like Receptors and CD40 for Antitumor Immunity.

Advanced materials (Deerfield Beach, Fla.)

Yan J,Zhang Y,Du S,Hou X,Li W,Zeng C,Zhang C,Cheng J,Deng B,McComb DW,Zhao W,Xue Y,Kang DD,Cheng X,Dong Y

25-0114-82 was used in Flow cytometry/Cell sorting to develop an immunotherapy regimen that enables co-stimulation of TLR7/8- and CD40-mediated pathways.

Tue Nov 01 00:00:00 EDT 2022

Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain.

eLife

Kovacs MA,Cowan MN,Babcock IW,Sibley LA,Still K,Batista SJ,Labuzan SA,Sethi I,Harris TH

25-0114-82 was used in Flow cytometry/Cell sorting to reveal that CNS lymphatic drainage supports the development of peripheral T cell responses against T. gondii but remains dispensable for immune protection of the brain.

Wed Dec 21 00:00:00 EST 2022

Tumor-Associated Lymphatics Upregulate MHC-II to Suppress Tumor-Infiltrating Lymphocytes.

International journal of molecular sciences

Li CY,Park HJ,Shin J,Baik JE,Mehrara BJ,Kataru RP

25-0114-82 was used in Flow cytometry/Cell sorting to suggest LECs can act as immunosuppressive cells in the TME in an MHC-II dependent manner.

Thu Nov 03 00:00:00 EDT 2022

IFN-γ-dependent tumor-antigen cross-presentation by lymphatic endothelial cells promotes their killing by T cells and inhibits metastasis.

Science advances

Garnier L,Pick R,Montorfani J,Sun M,Brighouse D,Liaudet N,Kammertoens T,Blankenstein T,Page N,Bernier-Latamani J,Tran NL,Petrova TV,Merkler D,Scheiermann C,Hugues S

25-0114-82 was used in Flow cytometry/Cell sorting to assess the impact of cytotoxic T cells on the local lymphatic vasculature and concomitant tumor dissemination during an antitumor response.

Fri Jun 10 00:00:00 EDT 2022

Lidocaine Ameliorates Psoriasis by Obstructing Pathogenic CGRP Signaling‒Mediated Sensory Neuron‒Dendritic Cell Communication.

The Journal of investigative dermatology

Yin Q,Sun L,Cai X,Lou F,Sun Y,Wang B,Jiang B,Bao L,Li X,Song N,Tang S,Bai J,Wang Z,Wu Y,Zhou H,Wang H,Yu B,Li Q,Wang H

25-0114-82 was used in Flow cytometry/Cell sorting to show that epidural nerve block with lidocaine demonstrates an effective therapy for psoriasis, which suppresses both inordinate sensory nerve growth in the inflamed skin and calcitonin gene-related peptide-mediated IL-23 production from psoriatic dendritic cells.

Mon Aug 01 00:00:00 EDT 2022

Cold exposure protects from neuroinflammation through immunologic reprogramming.

Cell metabolism

Spiljar M,Steinbach K,Rigo D,Suárez-Zamorano N,Wagner I,Hadadi N,Vincenti I,Page N,Klimek B,Rochat MA,Kreutzfeldt M,Chevalier C,Stojanović O,Bejuy O,Colin D,Mack M,Cansever D,Greter M,Merkler D,Trajkovski M

25-0114-82 was used in flow cytometry to propose a mechanistic link between environmental temperature and neuroinflammation and suggest competition between cold-induced metabolic adaptations and autoimmunity as energetic trade-off beneficial for the immune-mediated diseases.

Tue Nov 02 00:00:00 EDT 2021

Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma.

Scientific reports

Mittal A,Wang M,Vidyarthi A,Yanez D,Pizzurro G,Thakral D,Tracy E,Colegio OR

25-0114-82 was used in Flow Cytometry to demonstrate the therapeutic potential of transcutaneous arginase inhibition in cutaneous squamous cell carcinomas (cSCC).

Mon May 24 00:00:00 EDT 2021

Novel oncolytic adenovirus expressing enhanced cross-hybrid IgGA Fc PD-L1 inhibitor activates multiple immune effector populations leading to enhanced tumor killing in vitro, in vivo and with patient-derived tumor organoids.

Journal for immunotherapy of cancer

Hamdan F,Ylösmäki E,Chiaro J,Giannoula Y,Long M,Fusciello M,Feola S,Martins B,Feodoroff M,Antignani G,Russo S,Kari O,Lee M,Järvinen P,Nisen H,Kreutzman A,Leusen J,Mustjoki S,McWilliams TG,Grönholm M,Cerullo V

25-0114-82 was used in Flow cytometry/Cell sorting to designed an oncolytic adenovirus to increase efficacy while minimizing toxicity of PD-L1 immunecheckpoint therapy that secretes a cross-hybrid Fc-fusion peptide against PD-L1 able to elicit effector mechanisms of an IgG1 and also IgA1 consequently activating neutrophils, a population neglected by IgG1, in order to combine multiple effector mechanisms.

Sun Aug 01 00:00:00 EDT 2021

Inflammation-induced alterations in maternal-fetal Heme Oxygenase (HO) are associated with sustained innate immune cell dysregulation in mouse offspring.

PloS one

Ozen M,Zhao H,Kalish F,Yang Y,Jantzie LL,Wong RJ,Stevenson DK

25-0114-82 was used in Flow Cytometry to investigate the effects of an exposure to systemic inflammation late in gestation on wild-type and heme oxygenase-1 heterozygous mouse mothers, foetuses and offspring.

Wed Nov 17 00:00:00 EST 2021

Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.

Cell

Lee JY,Hall JA,Kroehling L,Wu L,Najar T,Nguyen HH,Lin WY,Yeung ST,Silva HM,Li D,Hine A,Loke P,Hudesman D,Martin JC,Kenigsberg E,Merad M,Khanna KM,Littman DR

25-0114 was used in Flow cytometry/Cell sorting to suggest that serum amyloid A proteins direct a pathogenic pro-inflammatory Th17 cell differentiation program and promote Th17-mediated inflammatory diseases.

Thu Jan 09 00:00:00 EST 2020

The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.

Cell

Kitamoto S,Nagao-Kitamoto H,Jiao Y,Gillilland MG,Hayashi A,Imai J,Sugihara K,Miyoshi M,Brazil JC,Kuffa P,Hill BD,Rizvi SM,Wen F,Bishu S,Inohara N,Eaton KA,Nusrat A,Lei YL,Giannobile WV,Kamada N

25-0114-82 was used in Flow Cytometry to conclude that oral inflammation, such as periodontitis, exacerbates gut inflammation by supplying the gut with both colitogenic pathobionts and pathogenic T cells.

Thu Jul 23 00:00:00 EDT 2020

Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection.

Immunity

Bosteels C,Neyt K,Vanheerswynghels M,van Helden MJ,Sichien D,Debeuf N,De Prijck S,Bosteels V,Vandamme N,Martens L,Saeys Y,Louagie E,Lesage M,Williams DL,Tang SC,Mayer JU,Ronchese F,Scott CL,Hammad H,Guilliams M,Lambrecht BN

25-0114 was used in Flow cytometry/Cell sorting to show that monocyte-derived inflammatory DCs’’ are a mixture of monocyte-derived MCs that have little migratory and APC potential and bona fide pre-cDCderived, CD26-expressing inf-cDC2s that depend on Flt3L but not on GM-CSF.

Tue Jun 16 00:00:00 EDT 2020

Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity.

Immunity

Turner JA,Stephen-Victor E,Wang S,Rivas MN,Abdel-Gadir A,Harb H,Cui Y,Fanny M,Charbonnier LM,Fong JJH,Benamar M,Wang L,Burton OT,Bansal K,Bry L,Zhu C,Li QZ,Clement RL,Oettgen HC,Crestani E,Rachid R,Sage PT,Chatila TA

25-0114-82 was used in Flow Cytometry to show that Treg cells in food allergy (FA) had decreased expression of transforming growth factor beta 1 (TGF-β1) because of interleukin-4 (IL-4)- and signal transducer and activator of transciription-6 (STAT6)-dependent inhibition of Tgfb1 transcription.

Tue Dec 15 00:00:00 EST 2020

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation.

The Journal of experimental medicine

Devos M,Tanghe G,Gilbert B,Dierick E,Verheirstraeten M,Nemegeer J,de Reuver R,Lefebvre S,De Munck J,Rehwinkel J,Vandenabeele P,Declercq W,Maelfait J

25-0114 was used in Flow cytometry/Cell sorting to show that sensing of endogenous nucleic acids by ZBP1 is critical in driving skin pathology characterised by antiviral and IL-17 immune responses.

Mon Jul 06 00:00:00 EDT 2020

Bcl6 and Blimp1 reciprocally regulate ST2⁺ Treg-cell development in the context of allergic airway inflammation.

The Journal of allergy and clinical immunology

Koh B,Ulrich BJ,Nelson AS,Panangipalli G,Kharwadkar R,Wu W,Xie MM,Fu Y,Turner MJ,Paczesny S,Janga SC,Dent AL,Kaplan MH

25-0114 was used in Flow cytometry/Cell sorting to define the functions of Bcl6 in Treg cells, including Tfr cells, in the context of allergic airway inflammation.

Sun Nov 01 00:00:00 EDT 2020

Systemic Expression of a Viral RdRP Protects against Retrovirus Infection and Disease.

Journal of virology

Miller CM,Barrett BS,Chen J,Morrison JH,Radomile C,Santiago ML,Poeschla EM

25-0114 was used in Flow cytometry/Cell sorting to provide evidence which could have implications for harnessing ISG responses to reduce transmission or control pathogenesis of human retroviral pathogens.

Thu Apr 16 00:00:00 EDT 2020

Convergent Met and voltage-gated Ca²⁺ channel signaling drives hypermigration of Toxoplasma-infected dendritic cells.

Journal of cell science

Ólafsson EB,Ten Hoeve AL,Li-Wang X,Westermark L,Varas-Godoy M,Barragan A

25-0114 was used in Flow cytometry/Cell sorting to provide a molecular basis for the hypermigratory mesenchymal-to-amoeboid transition (MAT) of parasitized dendritic cells.

Tue Apr 21 00:00:00 EDT 2020

Immune modulating effects of additional supplementation of estradiol combined with testosterone in murine testosterone-deficient NAFLD model.

American journal of physiology. Gastrointestinal and liver physiology

Okamura T,Hamaguchi M,Bamba R,Nakajima H,Yoshimura Y,Kimura T,Nishida K,Hashimoto Y,Fukuda T,Senmaru T,Fukui M

25-0114-82 was used in Flow cytometry/Cell sorting to suggest that a combination of estrogen and testosterone may be clinically relevant for the treatment of NAFLD in patients with male menopause.

Mon Jun 01 00:00:00 EDT 2020

Dietary Glucose Consumption Promotes RALDH Activity in Small Intestinal CD103⁺CD11b⁺ Dendritic Cells.

Frontiers in immunology

Ko HJ,Hong SW,Verma R,Jung J,Lee M,Kim N,Kim D,Surh CD,Kim KS,Rudra D,Im SH

25-0114 was used in Flow cytometry/Cell sorting to reveal previously underappreciated role of dietary glucose concentration in establishing regulatory properties in intestinal DCs, thereby extending a potential therapeutic module against intestinal inflammation.

Mon Apr 19 00:00:00 EDT 2021

Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury.

eLife

Lissner MM,Cumnock K,Davis NM,Vilches-Moure JG,Basak P,Navarrete DJ,Allen JA,Schneider D

25-0114-82 was used in Flow Cytometry to detail the host immune and metabolic response during sickness and recovery in a mouse model of malaria.

Tue Oct 06 00:00:00 EDT 2020

Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.

Cell reports

Cham LB,Torrez Dulgeroff LB,Tal MC,Adomati T,Li F,Bhat H,Huang A,Lang PA,Moreno ME,Rivera JM,Galkina SA,Kosikova G,Stoddart CA,McCune JM,Myers LM,Weissman IL,Lang KS,Hasenkrug KJ

25-0114 was used in Flow cytometry/Cell sorting to indicate that CD47 blockade not only enhances the function of innate immune cells but also links to adaptive immune responses through improved APC function.

Tue Apr 14 00:00:00 EDT 2020

Interferon Regulatory Factor-5 in Resident Macrophage Promotes Polycystic Kidney Disease.

Kidney360

Zimmerman KA,Huang J,He L,Revell DZ,Li Z,Hsu JS,Fitzgibbon WR,Hazard ES,Hardiman G,Mrug M,Bell PD,Yoder BK,Saigusa T

25-0114 was used in Flow cytometry/Cell sorting to suggest that Irf5 promotes inflammatory cytokine production in resident macrophages resulting in accelerated cystogenesis.

Sun Mar 01 00:00:00 EST 2020

Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.

Nature communications

Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G

25-0114 was used in Flow cytometry/Cell sorting to study the mechanism that controls the development of αβ T cell lineages in the thymus.

Mon May 04 00:00:00 EDT 2020

Distinct Transcriptional Responses across Tissue-Resident Macrophages to Short-Term and Long-Term Metabolic Challenge.

Cell reports

Brykczynska U,Geigges M,Wiedemann SJ,Dror E,Böni-Schnetzler M,Hess C,Donath MY,Paro R

25-0114 was used in Flow cytometry/Cell sorting to provide a resource for assessing the impact of nutrition and over-nutrition on the spectrum of macrophages across tissues with a potential for identification of systemic responses.

Tue Feb 04 00:00:00 EST 2020

Complete Topological Mapping of a Cellular Protein Interactome Reveals Bow-Tie Motifs as Ubiquitous Connectors of Protein Complexes.

Cell reports

Niss K,Gomez-Casado C,Hjaltelin JX,Joeris T,Agace WW,Belling KG,Brunak S

25-0114 was used in Flow cytometry/Cell sorting to provide knowledge on how intracellular protein connectivity is organized and operates.

Tue Jun 16 00:00:00 EDT 2020

Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1.

eLife

Madel MB,Ibáñez L,Ciucci T,Halper J,Rouleau M,Boutin A,Hue C,Duroux-Richard I,Apparailly F,Garchon HJ,Wakkach A,Blin-Wakkach C

25-0114-82 was used in Flow Cytometry to investigate the contribution of mouse Cx3cr1+ and Cx3cr1neg i-OCLs to bone loss.

Wed May 13 00:00:00 EDT 2020

Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses.

Scientific reports

Hrdý J,Alard J,Couturier-Maillard A,Boulard O,Boutillier D,Delacre M,Lapadatescu C,Cesaro A,Blanc P,Pot B,Ryffel B,Chamaillard M,Grangette C

25-0114-82 was used in Flow Cytometry to examine immunomodulatory properties of potential probiotic strains in Crohn's disease and colitis.

Tue Mar 24 00:00:00 EDT 2020

Pharmacological depletion of microglia and perivascular macrophages prevents Vascular Cognitive Impairment in Ang II-induced hypertension.

Theranostics

Kerkhofs D,van Hagen BT,Milanova IV,Schell KJ,van Essen H,Wijnands E,Goossens P,Blankesteijn WM,Unger T,Prickaerts J,Biessen EA,van Oostenbrugge RJ,Foulquier S

25-0114 was used in Flow cytometry/Cell sorting to support the critical role of brain immune cells in the pathogenesis of hypertension-related cognitive impairment.

Tue Jun 01 00:00:00 EDT 2021

Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities.

Nature communications

Cho SX,Rudloff I,Lao JC,Pang MA,Goldberg R,Bui CB,McLean CA,Stock M,Klassert TE,Slevogt H,Mangan NE,Cheng W,Fischer D,Gfroerer S,Sandhu MK,Ngo D,Bujotzek A,Lariviere L,Schumacher F,Tiefenthaler G,Beker F,Collins C,Kamlin COF,König K,Malhotra A,Tan K,Theda C,Veldman A,Ellisdon AM,Whisstock JC,Berger PJ,Nold-Petry CA,Nold MF

25-0114 was used in Flow cytometry/Cell sorting to implicate type 3 cytokines, TLRs and IL-37 as potential targets for novel Necrotizing enterocolitis therapies.

Fri Nov 13 00:00:00 EST 2020

Mechanisms of interleukin 4 mediated increase in efficacy of vaccines against opioid use disorders.

NPJ vaccines

Crouse B,Robinson C,Huseby Kelcher A,Laudenbach M,Abrahante JE,Pravetoni M

25-0114 was used in Flow cytometry/Cell sorting to find that blocking IL-4 improved the efficacy of vaccines targeting oxycodone and fentanyl in male and female mice.

Thu Oct 29 00:00:00 EDT 2020

L-Selectin/CD62L is a Key Driver of Non-Alcoholic Steatohepatitis in Mice and Men.

Cells

Drescher HK,Schippers A,Rosenhain S,Gremse F,Bongiovanni L,Bruin A,Eswaran S,Gallage SU,Pfister D,Szydlowska M,Heikenwalder M,Weiskirchen S,Wagner N,Trautwein C,Weiskirchen R,Kroy DC

25-0114 was used in Flow cytometry/Cell sorting to investigate the functional role of CD62L in NASH in humans as well as in two mouse models of steatohepatitis.

Wed Apr 29 00:00:00 EDT 2020

Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance.

Frontiers in immunology

Hering L,Katkeviciute E,Schwarzfischer M,Busenhart P,Gottier C,Mrdjen D,Komuczki J,Wawrzyniak M,Lang S,Atrott K,Becher B,Rogler G,Scharl M,Spalinger MR

25-0114 was used in Flow cytometry/Cell sorting to show dendritic cell PTPN2 might explain the central role for PTPN2 in the immune system to maintain immune tolerance.

Mon Apr 12 00:00:00 EDT 2021

GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation.

Cell reports

Castro-Dopico T,Fleming A,Dennison TW,Ferdinand JR,Harcourt K,Stewart BJ,Cader Z,Tuong ZK,Jing C,Lok LSC,Mathews RJ,Portet A,Kaser A,Clare S,Clatworthy MR

25-0114 was used in Flow cytometry/Cell sorting to identify granulocyte-macrophage colony stimulating factor (GM-CSF) as a critical regulator of intestinal macrophage activation in patients with IBD and mice with dextran sodium sulfate (DSS)-induced colitis.

Tue Jul 07 00:00:00 EDT 2020

Human and Mouse Transcriptome Profiling Identifies Cross-Species Homology in Pulmonary and Lymph Node Mononuclear Phagocytes.

Cell reports

Leach SM,Gibbings SL,Tewari AD,Atif SM,Vestal B,Danhorn T,Janssen WJ,Wager TD,Jakubzick CV

25-0114 was used in Flow cytometry/Cell sorting to created a gene expression compendium across 24 distinct human and murine lung and lymph node mononuclear phagocyte (MP), along with human blood and murine spleen MPs, to serve as validation datasets.

Tue Nov 03 00:00:00 EST 2020

Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression.

Nature communications

Yu L,Zhang B,Deochand D,Sacta MA,Coppo M,Shang Y,Guo Z,Zeng X,Rollins DA,Tharmalingam B,Li R,Chinenov Y,Rogatsky I,Hu X

25-0114 was used in Flow cytometry/Cell sorting to study the contribution of post-initiation steps to macrophage activation.

Fri May 08 00:00:00 EDT 2020

Relevance of PSGL-1 Expression in B Cell Development and Activation.

Frontiers in immunology

González-Tajuelo R,González-Sánchez E,Silván J,Muñoz-Callejas A,Vicente-Rabaneda E,García-Pérez J,Castañeda S,Urzainqui A

25-0114 was used in Flow cytometry/Cell sorting to conclude that although the expression of PSGL-1 in mature B cells is low, the lack of PSGL-1 compromises normal B cell development and it may also play a role in the maturation and activation of peripheral naïve B cells.

Fri Jul 16 00:00:00 EDT 2021

Compartmentalized gut lymph node drainage dictates adaptive immune responses.

Nature

Esterházy D,Canesso MCC,Mesin L,Muller PA,de Castro TBR,Lockhart A,ElJalby M,Faria AMC,Mucida D

25-0114-82 was used in Flow Cytometry to show drainage of gut-draining lymph nodes can resolve conflicting tolerogenic and inflammatory intestinal responses by encouraging antigen targeting to specific gut segments.

Wed May 01 00:00:00 EDT 2019

Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.

Cell

Jin C,Lagoudas GK,Zhao C,Bullman S,Bhutkar A,Hu B,Ameh S,Sandel D,Liang XS,Mazzilli S,Whary MT,Meyerson M,Germain R,Blainey PC,Fox JG,Jacks T

25-0114 was used in Flow cytometry/Cell sorting to link local microbiota-immune crosstalk to lung tumor development and thereby define key cellular and molecular mediators that may serve as effective targets in lung cancer intervention.

Thu Feb 21 00:00:00 EST 2019

The cis-Regulatory Atlas of the Mouse Immune System.

Cell

Yoshida H,Lareau CA,Ramirez RN,Rose SA,Maier B,Wroblewska A,Desland F,Chudnovskiy A,Mortha A,Dominguez C,Tellier J,Kim E,Dwyer D,Shinton S,Nabekura T,Qi Y,Yu B,Robinette M,Kim KW,Wagers A,Rhoads A,Nutt SL,Brown BD,Mostafavi S,Buenrostro JD,Benoist C

25-0114-82 was used in Flow Cytometry to generate matched epigenome and transcriptome measurements in 86 primary cell types that span the mouse immune system and its differentiation cascade.

Thu Feb 07 00:00:00 EST 2019

Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow.

Immunity

Walker JA,Clark PA,Crisp A,Barlow JL,Szeto A,Ferreira ACF,Rana BMJ,Jolin HE,Rodriguez-Rodriguez N,Sivasubramaniam M,Pannell R,Cruickshank J,Daly M,Haim-Vilmovsky L,Teichmann SA,McKenzie ANJ

25-0114 was used in Flow cytometry/Cell sorting to identify a discrete ILC2-committed population and delineated transition states between early progenitors and a highly heterogeneous ILC1, ILC3, and NK precursor cell cluster.

Tue Jul 16 00:00:00 EDT 2019

Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer.

Immunity

Dmitrieva-Posocco O,Dzutsev A,Posocco DF,Hou V,Yuan W,Thovarai V,Mufazalov IA,Gunzer M,Shilovskiy IP,Khaitov MR,Trinchieri G,Waisman A,Grivennikov SI

25-0114-82 was used in Flow Cytometry to examine the impact of IL-1 signaling, a key regulator of the IL-17 pathway, in different cell types within the CRC microenvironment.

Tue Jan 15 00:00:00 EST 2019

The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy.

Cellular & molecular immunology

Moschovakis GL,Bubke A,Friedrichsen M,Ristenpart J,Back JW,Falk CS,Kremmer E,Förster R

25-0114-82 was used in Flow Cytometry to demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA.

Tue Oct 01 00:00:00 EDT 2019

Engulfment of mast cell secretory granules on skin inflammation boosts dendritic cell migration and priming efficiency.

The Journal of allergy and clinical immunology

Dudeck J,Froebel J,Kotrba J,Lehmann CHK,Dudziak D,Speier S,Nedospasov SA,Schraven B,Dudeck A

25-0114 was used in Flow cytometry/Cell sorting to show peripheral mast cells can modify dendritic cell functionality to influence lymphoid tissue-borne adaptive immunity.

Wed May 01 00:00:00 EDT 2019

Macropinocytosis Overcomes Directional Bias in Dendritic Cells Due to Hydraulic Resistance and Facilitates Space Exploration.

Developmental cell

Moreau HD,Blanch-Mercader C,Attia R,Maurin M,Alraies Z,Sanséau D,Malbec O,Delgado MG,Bousso P,Joanny JF,Voituriez R,Piel M,Lennon-Duménil AM

25-0114 was used in flow cytometry to investigtate if barotaxis can result from the amplification of a small force imbalance by the actomyosin cytoskeleton, thus resulting in biased directional choices.

Mon Apr 22 00:00:00 EDT 2019

Human C-reactive protein aggravates osteoarthritis development in mice on a high-fat diet.

Osteoarthritis and cartilage

Kozijn AE,Tartjiono MT,Ravipati S,van der Ham F,Barrett DA,Mastbergen SC,Korthagen NM,Lafeber FPJG,Zuurmond AM,Bobeldijk I,Weinans H,Stoop R

25-0114 was used in Flow cytometry/Cell sorting to determine the role of C-reactive protein in the development of metabolic osteoarthritis.

Tue Jan 01 00:00:00 EST 2019

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus.

Cell reports

Gentili M,Lahaye X,Nadalin F,Nader GPF,Puig Lombardi E,Herve S,De Silva NS,Rookhuizen DC,Zueva E,Goudot C,Maurin M,Bochnakian A,Amigorena S,Piel M,Fachinetti D,Londoño-Vallejo A,Manel N

25-0114 was used in Flow cytometry/Cell sorting to reveal a preferential functional association of nuclear cGAS with centromeres.

Tue Feb 26 00:00:00 EST 2019

A β2-Integrin/MRTF-A/SRF Pathway Regulates Dendritic Cell Gene Expression, Adhesion, and Traction Force Generation.

Frontiers in immunology

Guenther C,Faisal I,Uotila LM,Asens ML,Harjunpää H,Savinko T,Öhman T,Yao S,Moser M,Morris SW,Tojkander S,Fagerholm SC

25-0114 was used in Flow cytometry/Cell sorting to demonstrate that mutation of the kindlin-3 binding site in the β2-integrin abolishes activation of the actin-regulated myocardin related transcription factor A/serum response factor signalling pathway in dendritic cells and MRTF-A/SRF-dependent gene expression.

Mon Aug 17 00:00:00 EDT 2020

Persistence of Integrase-Deficient Lentiviral Vectors Correlates with the Induction of STING-Independent CD8⁺ T Cell Responses.

Cell reports

Cousin C,Oberkampf M,Felix T,Rosenbaum P,Weil R,Fabrega S,Morante V,Negri D,Cara A,Dadaglio G,Leclerc C

25-0114 was used in Flow cytometry/Cell sorting to demonstrate that integrase-deficient lentiviral vectors can trigger persistent adaptive response by the mediation of a weak and transient innate response alongside the persistence of the vector in tissues.

Tue Jan 29 00:00:00 EST 2019

Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A.

Immunity

Wang M,Zhang S,Zheng G,Huang J,Songyang Z,Zhao X,Lin X

25-0114 was used in Flow cytometry/Cell sorting to show CARMA2 serves as a key mediator of IL-17A signaling and its constitutive activation in keratinocytes leads to the onset of psoriasis.

Tue Jul 17 00:00:00 EDT 2018

Insulin resistance causes inflammation in adipose tissue.

The Journal of clinical investigation

Shimobayashi M,Albert V,Woelnerhanssen B,Frei IC,Weissenberger D,Meyer-Gerspach AC,Clement N,Moes S,Colombi M,Meier JA,Swierczynska MM,Jenö P,Beglinger C,Peterli R,Hall MN

25-0114 was used in Flow cytometry/Cell sorting to elucidate the causal relationship between obesity-induced insulin resistance, and macrophage accumulation and inflammation in adipose tissue.

Mon Apr 02 00:00:00 EDT 2018

Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.

The Journal of clinical investigation

Tsantikos E,Lau M,Castelino CM,Maxwell MJ,Passey SL,Hansen MJ,McGregor NE,Sims NA,Steinfort DP,Irving LB,Anderson GP,Hibbs ML

25-0114 was used in Flow cytometry/Cell sorting to study the role of blood growth factors in chronic obstructive pulmonary disease.

Fri Jun 01 00:00:00 EDT 2018

Antigen-specific airway IL-33 production depends on FcγR-mediated incorporation of the antigen by alveolar macrophages in sensitized mice.

Immunology

Nabe T,Matsuda M,Ishida T,Tsujimoto N,Kido H,Kanaya H,Takahashi H,Takemoto N,Nomura M,Ishihara K,Akiba S,Mizutani N

25-0114 was used in Flow cytometry/Cell sorting to demonstrate that the administered OVA in the lung bound antigen-specific IgG Ab, and then alveolar macrophages incorporated the immune complex through FcγRII/III on the cell surface, resulting in IL-33 production in sensitized mice.

Sat Sep 01 00:00:00 EDT 2018

Macrophages orchestrate breast cancer early dissemination and metastasis.

Nature communications

Linde N,Casanova-Acebes M,Sosa MS,Mortha A,Rahman A,Farias E,Harper K,Tardio E,Reyes Torres I,Jones J,Condeelis J,Merad M,Aguirre-Ghiso JA

25-0114 was used in Flow cytometry/Cell sorting to show that, in pre-malignant lesions, CCL2 produced by cancer cells and myeloid cells attracts CD206+/Tie2+macrophages and induces Wnt-1 upregulation that in turn downregulates E-cadherin junctions in the HER2+early cancer cells.

Tue Jan 02 00:00:00 EST 2018

Gut microbiota modulates adoptive cell therapy via CD8α dendritic cells and IL-12.

JCI insight

Uribe-Herranz M,Bittinger K,Rafail S,Guedan S,Pierini S,Tanes C,Ganetsky A,Morgan MA,Gill S,Tanyi JL,Bushman FD,June CH,Facciabene A

25-0114 was used in Flow cytometry/Cell sorting to study the role of the gut microbiota in the antitumour effectiveness of adoptive cell therapy (ACT).

Thu Feb 22 00:00:00 EST 2018

Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1^I249/M280 Variant.

Frontiers in cellular neuroscience

Cardona SM,Kim SV,Church KA,Torres VO,Cleary IA,Mendiola AS,Saville SP,Watowich SS,Parker-Thornburg J,Soto-Ospina A,Araque P,Ransohoff RM,Cardona AE

25-0114 was used in Flow cytometry/Cell sorting to provide validation of defective function of the hCX3CR1I249/M280 variant and the foundation to broaden the understanding of microglia dysfunction during neuroinflammation.

Thu Oct 01 00:00:00 EDT 2020

Targeting the gut microbiome to treat the osteoarthritis of obesity.

JCI insight

Schott EM,Farnsworth CW,Grier A,Lillis JA,Soniwala S,Dadourian GH,Bell RD,Doolittle ML,Villani DA,Awad H,Ketz JP,Kamal F,Ackert-Bicknell C,Ashton JM,Gill SR,Mooney RA,Zuscik MJ

25-0114 was used in Flow cytometry/Cell sorting to show that reducing Tnf-associated inflammation in obesity is profoundly protective against osteoarthritis in mice.

Thu Apr 19 00:00:00 EDT 2018

Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes.

Scientific reports

Osum KC,Burrack AL,Martinov T,Sahli NL,Mitchell JS,Tucker CG,Pauken KE,Papas K,Appakalai B,Spanier JA,Fife BT

25-0114 was used in Flow cytometry/Cell sorting to suggest that insulin-producing Β cells respond to pancreatic inflammation and IFN-γ production by upregulating PD-L1 expression to limit self-reactive T cells.

Tue May 29 00:00:00 EDT 2018

Intravenous Labeling and Analysis of the Content of Thymic Perivascular Spaces.

Bio-protocol

Ruscher R,Hogquist KA

25-0114 was used in Flow cytometry/Cell sorting to investigate hematopoietic cell subsets within the perivascular spaces of the thymus.

Mon Mar 05 00:00:00 EST 2018

A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor.

Scientific reports

Wong TH,Lee CL,Su HH,Lee CL,Wu CC,Wang CC,Sheu CC,Lai RS,Leung SY,Lin CC,Wei YF,Wang CJ,Lin YC,Chen HL,Huang MS,Yen JH,Huang SK,Suen JL

25-0114 was used in Flow cytometry/Cell sorting to suggest that chronic exposure to environmental PAHs may pose a significant risk for asthma.

Mon Mar 26 00:00:00 EDT 2018

Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone.

Cell

Berry MR,Mathews RJ,Ferdinand JR,Jing C,Loudon KW,Wlodek E,Dennison TW,Kuper C,Neuhofer W,Clatworthy MR

25-0114-82 was used in Flow Cytometry to reveal a critical accessory role for the homeostatic function of a vital organ in optimizing tissue defense.

Thu Aug 24 00:00:00 EDT 2017

Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.

Immunity

Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,Donath MY

25-0114 was used in Flow cytometry/Cell sorting to provide evidence that an immunometabolic crosstalk between islet-derived IL-33, ILC2s, and myeloid cells fosters insulin secretion.

Tue Nov 21 00:00:00 EST 2017

ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.

The Journal of experimental medicine

Schwartz C,Khan AR,Floudas A,Saunders SP,Hams E,Rodewald HR,McKenzie ANJ,Fallon PG

25-0114 was used in Flow cytometry/Cell sorting to study how group 2 innate lymphoid cells regulate adaptive Th2 cell functions.

Mon Sep 04 00:00:00 EDT 2017

Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.

Cancer research

Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B

25-0114-82 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.

Wed Nov 01 00:00:00 EDT 2017

Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy.

Proceedings of the National Academy of Sciences of the United States of America

Engler JB,Kursawe N,Solano ME,Patas K,Wehrmann S,Heckmann N,Lühder F,Reichardt HM,Arck PC,Gold SM,Friese MA

25-0114 was used in Flow cytometry/Cell sorting to study the endocrine regulation of conventional and regulatory T cells during reproduction.

Tue Jan 10 00:00:00 EST 2017

IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model.

PLoS medicine

Xu J,Guardado J,Hoffman R,Xu H,Namas R,Vodovotz Y,Xu L,Ramadan M,Brown J,Turnquist HR,Billiar TR

25-0114 was used in Flow cytometry/Cell sorting to suggest that IL33 may initiate early detrimental type 2 immune responses after trauma through ILC2 regulation of neutrophil IL5 production.

Sat Jul 01 00:00:00 EDT 2017

Expression of Siglec-E Alters the Proteome of Lipopolysaccharide (LPS)-Activated Macrophages but Does Not Affect LPS-Driven Cytokine Production or Toll-Like Receptor 4 Endocytosis.

Frontiers in immunology

Nagala M,McKenzie E,Richards H,Sharma R,Thomson S,Mastroeni P,Crocker PR

25-0114 was used in Flow cytometry/Cell sorting to reveal that induction of siglec-E by LPS can modulate the phenotype of macrophages, the functional significance of which is currently unclear.

Wed Nov 20 00:00:00 EST 2019

Induction of Broad-Spectrum Protective Immunity against Disparate Cryptococcus Serotypes.

Frontiers in immunology

Van Dyke MCC,Chaturvedi AK,Hardison SE,Leopold Wager CM,Castro-Lopez N,Hole CR,Wozniak KL,Wormley FL

25-0114 was used in Flow cytometry/Cell sorting to provide "proof-of-concept" for the development of a cryptococcal vaccine that provides cross-protection against multiple disparate serotypes of Cryptococcus.

Wed Nov 20 00:00:00 EST 2019

Intestinal Batf3-dependent dendritic cells are required for optimal antiviral T-cell responses in adult and neonatal mice.

Mucosal immunology

Sun T,Rojas OL,Li C,Ward LA,Philpott DJ,Gommerman JL

25-0114 was used in Flow cytometry/Cell sorting to study the dendritic cell subset(s) that provoke antiviral responses within the gut.

Mon May 01 00:00:00 EDT 2017

Engaging the CD40-CD40L pathway augments T-helper cell responses and improves control of Mycobacterium tuberculosis infection.

PLoS pathogens

Sia JK,Bizzell E,Madan-Lala R,Rengarajan J

25-0114 was used in Flow cytometry/Cell sorting to determine the mechanism by which dendritic cells generate antigen specific T helper cells in response to Mycobacterium tuberculosis infection.

Tue Aug 01 00:00:00 EDT 2017

Genetic Nrf2 Overactivation Inhibits the Deleterious Effects Induced by Hepatocyte-Specific c-met Deletion during the Progression of NASH.

Oxidative medicine and cellular longevity

Ramadori P,Drescher H,Erschfeld S,Fragoulis A,Kensler TW,Wruck CJ,Cubero FJ,Trautwein C,Streetz KL,Kroy DC

25-0114 was used in Flow cytometry/Cell sorting to elucidate the effect of Nrf2 overactivation on cellular events in c-met deficient hepatocytes.

Wed Jan 31 00:00:00 EST 2018

The Second-Generation PGI2 Analogue Treprostinil Fails to Chemoprevent Tumors in a Murine Lung Adenocarcinoma Model.

Cancer prevention research (Philadelphia, Pa.)

Dwyer-Nield L,Hickey GA,Friedman M,Choo K,McArthur DG,Tennis MA,New ML,Geraci M,Keith RL

25-0114 was used in Flow cytometry/Cell sorting to study the ability of treprostinil to chemoprevent urethane-induced murine lung adenocarcinoma.

Wed Nov 01 00:00:00 EDT 2017

Modulation of Innate Immunity by lignin-Carbohydrate, a Novel TLR4 Ligand, Results in Augmentation of Mucosal IgA and Systemic IgG Production.

International journal of molecular sciences

Tsuji R,Ikado K,Fujiwara D

25-0114 was used in Flow cytometry/Cell sorting to investigate immune-stimulatory activity of lignin-rich enzyme lignin in vivo.

Tue Dec 26 00:00:00 EST 2017

Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A.

PLoS neglected tropical diseases

Floudas A,Cluxton CD,Fahel J,Khan AR,Saunders SP,Amu S,Alcami A,Fallon PG

25-0114 was used in Flow cytometry/Cell sorting to demonstrate the unique protein composition of the S. mansoni male worm secretome and immunomodulatory activity of S. mansoni Cyclophilin A.

Sun Oct 01 00:00:00 EDT 2017

Epstein Barr virus Latent Membrane Protein-1 enhances dendritic cell therapy lymph node migration, activation, and IL-12 secretion.

PloS one

Termini JM,Gupta S,Raffa FN,Guirado E,Fischl MA,Niu L,Kanagavelu S,Stone GW

25-0114 was used in Flow cytometry/Cell sorting to examine Epstein-Barr virus latent membrane protein-1 for its ability to mature and activate dendritic cells as a gene-based molecular adjuvant for DC vaccines.

Thu Oct 12 00:00:00 EDT 2017

Mononuclear Phagocytes Are Dispensable for Cardiac Remodeling in Established Pressure-Overload Heart Failure.

PloS one

Patel B,Ismahil MA,Hamid T,Bansal SS,Prabhu SD

25-0114 was used in Flow cytometry/Cell sorting to assess for alterations in MPs.

Thu Aug 10 00:00:00 EDT 2017

Dendritic cells, macrophages, NK and CD8⁺ T lymphocytes play pivotal roles in controlling HSV-1 in the trigeminal ganglia by producing IL1-beta, iNOS and granzyme B.

Virology journal

Lucinda N,Figueiredo MM,Pessoa NL,Santos BS,Lima GK,Freitas AM,Machado AM,Kroon EG,Antonelli LR,Campos MA

25-0114 was used in Flow cytometry/Cell sorting to provide strong evidence that the responses mediated by DCs, Mo/M?, NK and CD8+ T lymphocytes through IL-1β, iNOS and granzyme B production, respectively, together with the production of type I IFN early in the infection, are crucial to host defense against HSV-1.

Tue Feb 21 00:00:00 EST 2017

Identification of 14-dehydroergosterol as a novel anti-inflammatory compound inducing tolerogenic dendritic cells.

Scientific reports

Ano Y,Ikado K,Shindo K,Koizumi H,Fujiwara D

25-0114 was used in Flow cytometry/Cell sorting to investigate if 14-dehydroergosterol induces tolerogenic dendritic cells (DCs) to convert to a tolerogenic type.

Tue Oct 24 00:00:00 EDT 2017

Genetic lineage tracing identifies in situ Kit-expressing cardiomyocytes.

Cell research

Liu Q,Yang R,Huang X,Zhang H,He L,Zhang L,Tian X,Nie Y,Hu S,Yan Y,Zhang L,Qiao Z,Wang QD,Lui KO,Zhou B

25-0114 was used in Flow cytometry/Cell sorting to show that genetic lineage tracing can identify in-situ Kit expressing cardiomyocytes.

Fri Jan 01 00:00:00 EST 2016

The composition of the microbiota modulates allograft rejection.

The Journal of clinical investigation

Lei YM,Chen L,Wang Y,Stefka AT,Molinero LL,Theriault B,Aquino-Michaels K,Sivan AS,Nagler CR,Gajewski TF,Chong AS,Bartman C,Alegre ML

25-0114 was used in Flow cytometry/Cell sorting to test the influence of host and donor microbiota on skin transplant rejection.

Fri Jul 01 00:00:00 EDT 2016

Patrolling monocytes promote intravascular neutrophil activation and glomerular injury in the acutely inflamed glomerulus.

Proceedings of the National Academy of Sciences of the United States of America

Finsterbusch M,Hall P,Li A,Devi S,Westhorpe CL,Kitching AR,Hickey MJ

25-0114 was used in Flow cytometry/Cell sorting to examine the contributions of monocytes to antibody- and neutrophil-dependent inflammation in a model of in situ immune complex-mediated glomerulonephritis.

Tue Aug 30 00:00:00 EDT 2016

β7-Integrin exacerbates experimental DSS-induced colitis in mice by directing inflammatory monocytes into the colon.

Mucosal immunology

Schippers A,Muschaweck M,Clahsen T,Tautorat S,Grieb L,Tenbrock K,Gaßler N,Wagner N

25-0114 was used in Flow cytometry/Cell sorting to elucidate the significance of β7-integrin expression on innate immune cells for the pathogenesis of inflammatory bowel disease.

Tue Mar 01 00:00:00 EST 2016

Virus Infections Incite Pain Hypersensitivity by Inducing Indoleamine 2,3 Dioxygenase.

PLoS pathogens

Huang L,Ou R,Rabelo de Souza G,Cunha TM,Lemos H,Mohamed E,Li L,Pacholczyk G,Randall J,Munn DH,Mellor AL

25-0114 was used in Flow cytometry/Cell sorting to support the hypothesis that elevated IDO activity in non-CNS due to virus infections causes pain hypersensitivity mediated by Kyn.

Sun May 01 00:00:00 EDT 2016

IgE-mediated enhancement of CD4(+) T cell responses requires antigen presentation by CD8α(-) conventional dendritic cells.

Scientific reports

Ding Z,Dahlin JS,Xu H,Heyman B

25-0114 was used in Flow cytometry/Cell sorting to elucidate the dendritic cell population involved in the presentation of IgE-Ag complexes during enhanced specific antibody and CD4+ T cell responses.

Thu Jun 16 00:00:00 EDT 2016

Cathepsin L Helps to Defend Mice from Infection with Influenza A.

PloS one

Xu X,Greenland JR,Gotts JE,Matthay MA,Caughey GH

25-0114 was used in Flow cytometry/Cell sorting to show that cathepsin L supports innate and adaptive responses, confering a survival advantage on mice infected with the orthomyxovirus influenza A.

Tue Jun 20 00:00:00 EDT 2017

Tetherin/BST-2 promotes dendritic cell activation and function during acute retrovirus infection.

Scientific reports

Li SX,Barrett BS,Guo K,Kassiotis G,Hasenkrug KJ,Dittmer U,Gibbert K,Santiago ML

25-0114 was used in Flow cytometry/Cell sorting to investigate the role of Tetherin in counteracting retrovirus replication in vivo.

Fri Feb 05 00:00:00 EST 2016

Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.

eLife

Allison KA,Sajti E,Collier JG,Gosselin D,Troutman TD,Stone EL,Hedrick SM,Glass CK

25-0114 was used in Flow cytometry/Cell sorting to investigate relationship between the strength of antigenic stimulation and the response of mouse CD4+ T cells.

Mon Jul 04 00:00:00 EDT 2016

CpG-oligodeoxynucleotides exert remarkable antitumor activity against diffuse malignant peritoneal mesothelioma orthotopic xenografts.

Journal of translational medicine

De Cesare M,Sfondrini L,Pennati M,De Marco C,Motta V,Tagliabue E,Deraco M,Balsari A,Zaffaroni N

25-0114 was used in Flow cytometry/Cell sorting to indicate that locally administered CpG-ODN1826 is able to markedly affect the growth of both early- and late-stage DMPM orthotopic xenografts in the absence of severe side effects.

Mon Jan 25 00:00:00 EST 2016

A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome.

JCI insight

Srivastava N,Iyer S,Sudan R,Youngs C,Engelman RW,Howard KT,Russo CM,Chisholm JD,Kerr WG

25-0114 was used in Flow cytometry/Cell sorting to investigate how SHIPi represents an approach that permits control of obesity and diet-induced metabolic syndrome without apparent toxicity.

Thu Jul 21 00:00:00 EDT 2016

Dendritic cell function and pathogen-specific T cell immunity are inhibited in mice administered levonorgestrel prior to intranasal Chlamydia trachomatis infection.

Scientific reports

Quispe Calla NE,Vicetti Miguel RD,Mei A,Fan S,Gilmore JR,Cherpes TL

25-0114 was used in Flow cytometry/Cell sorting to demonstrate that levonorgestrel suppresses dendritic cell activation and function, and inhibits formation of pathogen-specific T-cell immunity.

Mon Nov 28 00:00:00 EST 2016

Heme Oxygenase-1-Expressing Dendritic Cells Promote Foxp3+ Regulatory T Cell Differentiation and Induce Less Severe Airway Inflammation in Murine Models.

PloS one

Wong TH,Chen HA,Gau RJ,Yen JH,Suen JL

25-0114 was used in Flow cytometry/Cell sorting to study the role of heme oxygenase-1 in dendritic cell-mediated T cell differentiation.

Mon Jul 10 00:00:00 EDT 2017

Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease.

Nature medicine

Chimen M,McGettrick HM,Apta B,Kuravi SJ,Yates CM,Kennedy A,Odedra A,Alassiri M,Harrison M,Martin A,Barone F,Nayar S,Hitchcock JR,Cunningham AF,Raza K,Filer A,Copland DA,Dick AD,Robinson J,Kalia N,Walker LSK,Buckley CD,Nash GB,Narendran P,Rainger GE

25-0114 was used in Flow cytometry/Cell sorting to demonstrate that exogenous PEPITEM reduces T cell recruitment into inflamed tissues in multiple animal models of autoimmune, inflammatory diseases.

Fri May 01 00:00:00 EDT 2015

Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.

Nature neuroscience

Haines JD,Herbin O,de la Hera B,Vidaurre OG,Moy GA,Sun Q,Fung HY,Albrecht S,Alexandropoulos K,McCauley D,Chook YM,Kuhlmann T,Kidd GJ,Shacham S,Casaccia P

25-0114 was used in Flow cytometry/Cell sorting to reveal that CRM1 inhibitors have the ability to modulate the export of molecules associated with both axonal damage and also neuroprotection.

Wed Apr 01 00:00:00 EDT 2015

T Lymphocyte-Specific Activation of Nrf2 Protects from AKI.

Journal of the American Society of Nephrology : JASN

Noel S,Martina MN,Bandapalle S,Racusen LC,Potteti HR,Hamad AR,Reddy SP,Rabb H

25-0114 was used in Flow cytometry/Cell sorting to study how T lymphocyte-specific activation of Nrf2 protects from IR-induced AKI, and investigate the novel mechanism of tissue protection behind this.

Tue Dec 01 00:00:00 EST 2015

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.

Annals of neurology

Butovsky O,Jedrychowski MP,Cialic R,Krasemann S,Murugaiyan G,Fanek Z,Greco DJ,Wu PM,Doykan CE,Kiner O,Lawson RJ,Frosch MP,Pochet N,Fatimy RE,Krichevsky AM,Gygi SP,Lassmann H,Berry J,Cudkowicz ME,Weiner HL

25-0114 was used in Flow cytometry/Cell sorting to investigate the role of miR-155 in SOD1 mice and human amyotrophic lateral sclerosis.

Thu Jan 01 00:00:00 EST 2015

Diverse roles for T-bet in the effector responses required for resistance to infection.

Journal of immunology (Baltimore, Md. : 1950)

Harms Pritchard G,Hall AO,Christian DA,Wagage S,Fang Q,Muallem G,John B,Glatman Zaretsky A,Dunn WG,Perrigoue J,Reiner SL,Hunter CA

25-0114 was used in Flow cytometry/Cell sorting to highlight T-bet-independent pathways to IFN-γ production and reveal a novel role for this transcription factor in coordinating the T cell responses necessary to control infection in peripheral tissues.

Sun Feb 01 00:00:00 EST 2015

Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women.

Journal of immunology (Baltimore, Md. : 1950)

Griesbeck M,Ziegler S,Laffont S,Smith N,Chauveau L,Tomezsko P,Sharei A,Kourjian G,Porichis F,Hart M,Palmer CD,Sirignano M,Beisel C,Hildebrandt H,Cénac C,Villani AC,Diefenbach TJ,Le Gall S,Schwartz O,Herbeuval JP,Autran B,Guéry JC,Chang JJ,Altfeld M

25-0114 was used in Flow cytometry/Cell sorting to demonstrate a critical mechanism by which sex differences in basal pDC IRF5 expression lead to higher IFN-α production upon TLR7 stimulation in females.

Tue Dec 01 00:00:00 EST 2015

Modulation of tumorigenesis by the pro-inflammatory microRNA miR-301a in mouse models of lung cancer and colorectal cancer.

Cell discovery

Ma X,Yan F,Deng Q,Li F,Lu Z,Liu M,Wang L,Conklin DJ,McCracken J,Srivastava S,Bhatnagar A,Li Y

25-0114 was used in Flow cytometry/Cell sorting to investigate modulation of tumorigenesis by the pro-inflammatory microRNA miR-301a in mouse models of lung cancer and colorectal cancer.

Wed Jul 27 00:00:00 EDT 2016

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases.

Nature communications

Kanno A,Tanimura N,Ishizaki M,Ohko K,Motoi Y,Onji M,Fukui R,Shimozato T,Yamamoto K,Shibata T,Sano S,Sugahara-Tobinai A,Takai T,Ohto U,Shimizu T,Saitoh S,Miyake K

25-0114 was used in Flow cytometry/Cell sorting to show that Toll-like receptor 7 (TLR7) is present on the cell surface of immune cells and that TLR7 responses can be inhibited by an anti-TLR7 antibody.

Wed Feb 04 00:00:00 EST 2015

Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injury.

Journal of neuroinflammation

Febinger HY,Thomasy HE,Pavlova MN,Ringgold KM,Barf PR,George AM,Grillo JN,Bachstetter AD,Garcia JA,Cardona AE,Opp MR,Gemma C

25-0114 was used in Flow cytometry/Cell sorting to evaluate the range of effects resulting from the genetic deletion of CX3CR1.

Wed Sep 02 00:00:00 EDT 2015

Virulence-Dependent Alterations in the Kinetics of Immune Cells during Pulmonary Infection by Mycobacterium tuberculosis.

PloS one

Kim WS,Kim JS,Cha SB,Han SJ,Kim H,Kwon KW,Kim SJ,Eum SY,Cho SN,Shin SJ

25-0114 was used in Flow cytometry/Cell sorting to compare the bacterial burden, inflammation and kinetics of immune cells during aerogenic infection in the lung between laboratory-adapted strains (Mtb H37Rv and H37Ra) and Mtb K strain.

Mon Jun 27 00:00:00 EDT 2016

Dendritic Cells Cause Bone Lesions in a New Mouse Model of Histiocytosis.

PloS one

Grosjean F,Nasi S,Schneider P,Chobaz V,Liu A,Mordasini V,Moullec K,Vezzoni P,Lavanchy C,Busso N,Acha-Orbea H,Ehirchiou D

25-0114 was used in Flow cytometry/Cell sorting to investigate the pathogenesis of Langerhans cell histiocytosis, showing that dendritic cells cause bone lesions in a new mouse model of the disease.

Tue May 17 00:00:00 EDT 2016

Lignin-rich enzyme lignin (LREL), a cellulase-treated lignin-carbohydrate derived from plants, activates myeloid dendritic cells via Toll-like receptor 4 (TLR4).

The Journal of biological chemistry

Tsuji R,Koizumi H,Aoki D,Watanabe Y,Sugihara Y,Matsushita Y,Fukushima K,Fujiwara D

25-0114 was used in Flow cytometry/Cell sorting to investigate the role of lignin-rich enzyme lignin in dendritic cells.

Fri Feb 13 00:00:00 EST 2015

Disruption of Fractalkine Signaling Leads to Microglial Activation and Neuronal Damage in the Diabetic Retina.

ASN neuro

Cardona SM,Mendiola AS,Yang YC,Adkins SL,Torres V,Cardona AE

25-0114 was used in Flow cytometry/Cell sorting to determine the role of CX3CR1 in inflammatory-mediated damage to retinal neurons.

Tue Jun 07 00:00:00 EDT 2016

Apoptotic cell clearance of Leishmania major-infected neutrophils by dendritic cells inhibits CD8⁺ T-cell priming in vitro by Mer tyrosine kinase-dependent signaling.

Cell death & disease

Ribeiro-Gomes FL,Romano A,Lee S,Roffê E,Peters NC,Debrabant A,Sacks D

25-0114 was used in Flow cytometry/Cell sorting to define the clearance of infected neutrophils by dendritic cells as central to the early immune evasion strategies of L. major.

Thu Dec 10 00:00:00 EST 2015

Poly(I:C) and CpG-ODN combined aerosolization to treat lung metastases and counter the immunosuppressive microenvironment.

Oncoimmunology

Le Noci V,Tortoreto M,Gulino A,Storti C,Bianchi F,Zaffaroni N,Tripodo C,Tagliabue E,Balsari A,Sfondrini L

25-0114 was used in Flow cytometry/Cell sorting to evaluated aerosol delivery CpG-ODN combined with Poly(I:C) in the treatment of B16 melanoma lung metastases in C57BL/6 mice.

Thu Oct 01 00:00:00 EDT 2015

CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload.

Circulation

Laroumanie F,Douin-Echinard V,Pozzo J,Lairez O,Tortosa F,Vinel C,Delage C,Calise D,Dutaur M,Parini A,Pizzinat N

25-0114 was used in Flow cytometry/Cell sorting to investigate the involvement of T cells in the progression to heart failure using a transverse aortic constriction (TAC) model.

Tue May 27 00:00:00 EDT 2014

The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.

Nature immunology

Agudo J,Ruzo A,Tung N,Salmon H,Leboeuf M,Hashimoto D,Becker C,Garrett-Sinha LA,Baccarini A,Merad M,Brown BD

25-0114 was used in Flow cytometry/Cell sorting to identify the miR-126-VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs.

Wed Jan 01 00:00:00 EST 2014

Identification of a unique TGF-β-dependent molecular and functional signature in microglia.

Nature neuroscience

Butovsky O,Jedrychowski MP,Moore CS,Cialic R,Lanser AJ,Gabriely G,Koeglsperger T,Dake B,Wu PM,Doykan CE,Fanek Z,Liu L,Chen Z,Rothstein JD,Ransohoff RM,Gygi SP,Antel JP,Weiner HL

25-0114 was used in Flow cytometry/Cell sorting to study gene expression in microglia versus myeloid and other immune cells.

Wed Jan 01 00:00:00 EST 2014

CLEC-2 is required for development and maintenance of lymph nodes.

Blood

Bénézech C,Nayar S,Finney BA,Withers DR,Lowe K,Desanti GE,Marriott CL,Watson SP,Caamaño JH,Buckley CD,Barone F

25-0114 was used in Flow cytometry/Cell sorting to investigate the role that CLEC-2 plays in the development and maintenance of lymph nodes.

Thu May 15 00:00:00 EDT 2014

Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation.

Science translational medicine

Beale J,Jayaraman A,Jackson DJ,Macintyre JDR,Edwards MR,Walton RP,Zhu J,Man Ching Y,Shamji B,Edwards M,Westwick J,Cousins DJ,Yi Hwang Y,McKenzie A,Johnston SL,Bartlett NW

25-0114 was used in Flow cytometry/Cell sorting to demonstrate asthmatic epithelial cells have an increased intrinsic capacity for expression of a pro-type 2 cytokine in response to a viral infection.

Wed Oct 01 00:00:00 EDT 2014

CX₃CR1⁺ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22.

The Journal of experimental medicine

Longman RS,Diehl GE,Victorio DA,Huh JR,Galan C,Miraldi ER,Swaminath A,Bonneau R,Scherl EJ,Littman DR

25-0114 was used in Flow cytometry/Cell sorting to study the role of CX3CR1+ mononuclear phagocytes in the development of colitis and disease progression following Citrobacter rodentium infection.

Mon Jul 28 00:00:00 EDT 2014

Intravascular staining for discrimination of vascular and tissue leukocytes.

Nature protocols

Anderson KG,Mayer-Barber K,Sung H,Beura L,James BR,Taylor JJ,Qunaj L,Griffith TS,Vezys V,Barber DL,Masopust D

25-0114 was used in Flow cytometry/Cell sorting to outline a protocol for the validation and use of intravascular staining to define innate and adaptive immune cells in mice.

Wed Jan 01 00:00:00 EST 2014

Tissues in different anatomical sites can sculpt and vary the tumor microenvironment to affect responses to therapy.

Molecular therapy : the journal of the American Society of Gene Therapy

Devaud C,Westwood JA,John LB,Flynn JK,Paquet-Fifield S,Duong CP,Yong CS,Pegram HJ,Stacker SA,Achen MG,Stewart TJ,Snyder LA,Teng MW,Smyth MJ,Darcy PK,Kershaw MH

25-0114 was used in Flow cytometry/Cell sorting to explore the relationship between tumour microenvironments and efficacy of immunotherapy.

Wed Jan 01 00:00:00 EST 2014

Large T Antigen-Specific Cytotoxic T Cells Protect Against Dendritic Cell Tumors through Perforin-Mediated Mechanisms Independent of CD4 T Cell Help.

Frontiers in immunology

Duval A,Fuertes Marraco SA,Schwitter D,Leuenberger L,Acha-Orbea H

25-0114 was used in Flow cytometry/Cell sorting to observe that after transfer into syngeneic C57BL/6 mice, MuTuDC lines were quickly rejected.

Thu Aug 07 00:00:00 EDT 2014

Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii.

PLoS pathogens

Dupont CD,Christian DA,Selleck EM,Pepper M,Leney-Greene M,Harms Pritchard G,Koshy AA,Wagage S,Reuter MA,Sibley LD,Betts MR,Hunter CA

25-0114 was used in Flow cytometry/Cell sorting to identify a critical role for actively infected host cells in initiating T. gondii-specific CD4+ and CD8+ T cell responses.

Tue Apr 01 00:00:00 EDT 2014

Boosting functional avidity of CD8+ T cells by vaccinia virus vaccination depends on intrinsic T-cell MyD88 expression but not the inflammatory milieu.

Journal of virology

Hu Z,Wang J,Wan Y,Zhu L,Ren X,Qiu S,Ren Y,Yuan S,Ding X,Chen J,Qiu C,Sun J,Zhang X,Xiang J,Qiu C,Xu J

25-0114 was used in Flow cytometry/Cell sorting to investigate how vaccinia-vectored vaccine (VACV) shapes the properties of memory CD8+ T cells, showing that it depends on intrinsic T-cell MyD88 expression.

Thu May 01 00:00:00 EDT 2014

Vaccination with a fusion protein that introduces HIV-1 gag antigen into a multitrimer CD40L construct results in enhanced CD8+ T cell responses and protection from viral challenge by vaccinia-gag.

Journal of virology

Gupta S,Termini JM,Raffa FN,Williams CA,Kornbluth RS,Stone GW

25-0114 was used in Flow cytometry/Cell sorting to show the potential of a vaccine design in which antigen is introduced into a multitrimer CD40L construct.

Sat Feb 01 00:00:00 EST 2014

Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness.

Laboratory investigation; a journal of technical methods and pathology

Wang Y,Jin TH,Farhana A,Freeman J,Estell K,Zmijewski JW,Gaggar A,Thannickal VJ,Schwiebert LM,Steyn AJ,Deshane JS

25-0114 was used in Flow cytometry/Cell sorting to assess the effects of exposing myeloid-derived regulatory cells to cigarette smoke on the production of nitric oxide.

Mon Dec 01 00:00:00 EST 2014

Tetherin promotes the innate and adaptive cell-mediated immune response against retrovirus infection in vivo.

Journal of immunology (Baltimore, Md. : 1950)

Li SX,Barrett BS,Heilman KJ,Messer RJ,Liberatore RA,Bieniasz PD,Kassiotis G,Hasenkrug KJ,Santiago ML

25-0114 was used in Flow cytometry/Cell sorting to investigate the immunological impact of Tetherin during retrovirus infection.

Tue Jul 01 00:00:00 EDT 2014

Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils.

Journal of immunology (Baltimore, Md. : 1950)

Jiao J,Dragomir AC,Kocabayoglu P,Rahman AH,Chow A,Hashimoto D,Leboeuf M,Kraus T,Moran T,Carrasco-Avino G,Friedman SL,Merad M,Aloman C

25-0114 was used in Flow cytometry/Cell sorting to investigate the role of dendritic cells in neutrophil homeostasis, showing a central role in regulation of bone marrow release and survival of neutrophils.

Tue Apr 01 00:00:00 EDT 2014

Helping themselves: optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Olson MR,Seah SG,Cullen J,Greyer M,Edenborough K,Doherty PC,Bedoui S,Lew AM,Turner SJ

25-0114 was used in Flow cytometry/Cell sorting to investigate whether induction of CD4(+) Th responses postinfection are also dependent on CD4(+) T cell help.

Mon Dec 01 00:00:00 EST 2014

Use of transgenic parasites and host reporters to dissect events that promote interleukin-12 production during toxoplasmosis.

Infection and immunity

Christian DA,Koshy AA,Reuter MA,Betts MR,Boothroyd JC,Hunter CA

25-0114 was used in Flow cytometry/Cell sorting to study the cell types which secrete IL-12p40 during Toxoplasma gondii infection.

Wed Oct 01 00:00:00 EDT 2014

Systemic and mucosal immune reactivity upon Mycobacterium avium ssp. paratuberculosis infection in mice.

PloS one

Koc A,Bargen I,Suwandi A,Roderfeld M,Tschuschner A,Rath T,Gerlach GF,Hornef M,Goethe R,Weiss S,Roeb E

25-0114 was used in Flow cytometry/Cell sorting to study immune responses to Mycobacterium avium ssp. paratuberculosis infection to assess a link to the development of Crohn's disease.

Fri May 29 00:00:00 EDT 2015

Molecular signatures of the evolving immune response in mice following a Bordetella pertussis infection.

PloS one

Raeven RH,Brummelman J,Pennings JL,Nijst OE,Kuipers B,Blok LE,Helm K,van Riet E,Jiskoot W,van Els CA,Han WG,Kersten GF,Metz B

25-0114 was used in Flow cytometry/Cell sorting to study how molecular and cellular immunological processes in response to live B. pertussis infection were unraveled.

Mon Oct 26 00:00:00 EDT 2015

Foxp3 expression in macrophages associated with RENCA tumors in mice.

PloS one

Devaud C,Yong CS,John LB,Westwood JA,Duong CP,House CM,Denoyer D,Li J,Darcy PK,Kershaw MH

25-0114 was used in Flow cytometry/Cell sorting to study how tumour-associated macrophages could express Foxp3.

Mon Nov 16 00:00:00 EST 2015

Dendritic cell subset distributions in the aorta in healthy and atherosclerotic mice.

PloS one

Busch M,Westhofen TC,Koch M,Lutz MB,Zernecke A

25-0114 was used in Flow cytometry/Cell sorting to perform a systematic analysis of dendritic cells and their accumulation characteristics during atherogenesis.

Tue Oct 21 00:00:00 EDT 2014

B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction.

Nature medicine

Zouggari Y,Ait-Oufella H,Bonnin P,Simon T,Sage AP,Guérin C,Vilar J,Caligiuri G,Tsiantoulas D,Laurans L,Dumeau E,Kotti S,Bruneval P,Charo IF,Binder CJ,Danchin N,Tedgui A,Tedder TF,Silvestre JS,Mallat Z

25-0114 was used in Flow cytometry/Cell sorting to identify the interaction between mature B lymphocytes and monocytes as a potential therapeutic target after a heart attack.

Tue Oct 01 00:00:00 EDT 2013

The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.

Nature immunology

Bell BD,Kitajima M,Larson RP,Stoklasek TA,Dang K,Sakamoto K,Wagner KU,Kaplan DH,Reizis B,Hennighausen L,Ziegler SF

25-0114 was used in Flow cytometry/Cell sorting to investigate how type-2 immunity is affected by STAT5 transcription factor in dendritic cells.

Mon Apr 01 00:00:00 EDT 2013

Ecto-5'-nucleotidase on immune cells protects from adverse cardiac remodeling.

Circulation research

Bönner F,Borg N,Jacoby C,Temme S,Ding Z,Flögel U,Schrader J

25-0114 was used in Flow cytometry/Cell sorting to examine the role of CD73 in cardiac repair and remodelling in mice after reperfused myocardial infarction.

Fri Jul 19 00:00:00 EDT 2013

p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells.

The Journal of experimental medicine

Iannello A,Thompson TW,Ardolino M,Lowe SW,Raulet DH

25-0114 was used in Flow cytometry/Cell sorting to study how NK cells participate in the elimination of senescent tumours.

Mon Sep 23 00:00:00 EDT 2013

Differential effects of aging and sex on stroke induced inflammation across the lifespan.

Experimental neurology

Manwani B,Liu F,Scranton V,Hammond MD,Sansing LH,McCullough LD

25-0114 was used in Flow cytometry/Cell sorting to evaluate the relative contribution of several key factors determining stroke outcome.

Fri Nov 01 00:00:00 EDT 2013

Regulation of adaptive immunity by the fractalkine receptor during autoimmune inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Garcia JA,Pino PA,Mizutani M,Cardona SM,Charo IF,Ransohoff RM,Forsthuber TG,Cardona AE

25-0114 was used in Flow cytometry/Cell sorting to determine the role of CX3CR1 in the trafficking and function of myeloid cells during experimental autoimmune encephalomyelitis.

Thu Aug 01 00:00:00 EDT 2013

IFN-α treatment inhibits acute Friend retrovirus replication primarily through the antiviral effector molecule Apobec3.

Journal of immunology (Baltimore, Md. : 1950)

Harper MS,Barrett BS,Smith DS,Li SX,Gibbert K,Dittmer U,Hasenkrug KJ,Santiago ML

25-0114 was used in Flow cytometry/Cell sorting to discern whether the ability of IFN-α to reduce viral load is achieved using restriction factors.

Fri Feb 15 00:00:00 EST 2013

Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Ohta S,Imamura M,Xing W,Boyce JA,Balestrieri B

25-0114 was used in Flow cytometry/Cell sorting to identify a unique function for gV-sPLA2 in the activation and recruitment of immune cells.

Sat Jun 15 00:00:00 EDT 2013

Bisphosphonates target B cells to enhance humoral immune responses.

Cell reports

Tonti E,Jiménez de Oya N,Galliverti G,Moseman EA,Di Lucia P,Amabile A,Sammicheli S,De Giovanni M,Sironi L,Chevrier N,Sitia G,Gennari L,Guidotti LG,von Andrian UH,Iannacone M

25-0114 was used in Flow cytometry/Cell sorting to demonstrate that the administration of clinically relevant doses of bisphosphonates in mice has an adjuvant effect.

Thu Oct 31 00:00:00 EDT 2013

Fv1 restriction and retrovirus vaccine immunity in Apobec3-deficient 129P2 mice.

PloS one

Halemano K,Barrett BS,Li SX,Harper MS,Smith DS,Heilman KJ,Santiago ML

25-0114 was used in Flow cytometry/Cell sorting to show that B-tropic FV infection of 129P2 mice may be a useful model to study the immunological pathways induced by retroviral capsid restriction.

Wed Sep 11 00:00:00 EDT 2013

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.

Nature

von Moltke J,Trinidad NJ,Moayeri M,Kintzer AF,Wang SB,van Rooijen N,Brown CR,Krantz BA,Leppla SH,Gronert K,Vance RE

25-0114 was used in Flow cytometry/Cell sorting to identify novel caspase-1 protease functions in vivo using a strategy for cytosolic delivery of bacterial flagellin, a NAIP5 inflammasome ligand.

Thu Oct 04 00:00:00 EDT 2012

The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.

Immunity

Hall AO,Beiting DP,Tato C,John B,Oldenhove G,Lombana CG,Pritchard GH,Silver JS,Bouladoux N,Stumhofer JS,Harris TH,Grainger J,Wojno ED,Wagage S,Roos DS,Scott P,Turka LA,Cherry S,Reiner SL,Cua D,Belkaid Y,Elloso MM,Hunter CA

25-0114 was used in an ELISA assay to study the promotion of distinct Treg cell populations by the cytokines IL-27 and IFN-y, and the role they play in limiting infection induced pathology.

Fri Sep 21 00:00:00 EDT 2012

The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor α signaling.

Blood

Seillet C,Laffont S,Trémollières F,Rouquié N,Ribot C,Arnal JF,Douin-Echinard V,Gourdy P,Guéry JC

25-0114 was used in Flow cytometry/Cell sorting to uncover a role for estrogens in regulating the innate functions of plasmacytoid dendritic cells.

Thu Jan 12 00:00:00 EST 2012

IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.

Blood

Balkhi MY,Willette-Brown J,Zhu F,Chen Z,Liu S,Guttridge DC,Karin M,Hu Y

25-0114-82 was used in Flow Cytometry to demonstrate that IKKα regulates B-lineage commitment via combined canonical and noncanonical NF-κB transcriptional activities to target Pax5 expression during hematopoiesis.

Thu Jun 07 00:00:00 EDT 2012

Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung.

The Journal of experimental medicine

Thornton EE,Looney MR,Bose O,Sen D,Sheppard D,Locksley R,Huang X,Krummel MF

25-0114 was used in Flow cytometry/Cell sorting to track the sites and timing of antigen uptake or subsequent antigen presentation to effector T cells after allergen challenge in asthma.

Mon Jun 04 00:00:00 EDT 2012

Harnessing oncolytic virus-mediated antitumor immunity in an infected cell vaccine.

Molecular therapy : the journal of the American Society of Gene Therapy

Lemay CG,Rintoul JL,Kus A,Paterson JM,Garcia V,Falls TJ,Ferreira L,Bridle BW,Conrad DP,Tang VA,Diallo JS,Arulanandam R,Le Boeuf F,Garson K,Vanderhyden BC,Stojdl DF,Lichty BD,Atkins HL,Parato KA,Bell JC,Auer RC

25-0114 was used in Flow cytometry/Cell sorting to develop a novel OV-infected cell treatment for a robust antitumour T-cell response effective against a broader range of tumours.

Sat Sep 01 00:00:00 EDT 2012

Mixed vector immunization with recombinant adenovirus and MVA can improve vaccine efficacy while decreasing antivector immunity.

Molecular therapy : the journal of the American Society of Gene Therapy

Reyes-Sandoval A,Rollier CS,Milicic A,Bauza K,Cottingham MG,Tang CK,Dicks MD,Wang D,Longley RJ,Wyllie DH,Hill AV

25-0114 was used in Flow cytometry/Cell sorting to investigate whether the two vaccine components adenovirus and modified vaccinia virus Ankara can be co-injected to enhance protection against malaria.

Wed Aug 01 00:00:00 EDT 2012

ORFV: a novel oncolytic and immune stimulating parapoxvirus therapeutic.

Molecular therapy : the journal of the American Society of Gene Therapy

Rintoul JL,Lemay CG,Tai LH,Stanford MM,Falls TJ,de Souza CT,Bridle BW,Daneshmand M,Ohashi PS,Wan Y,Lichty BD,Mercer AA,Auer RC,Atkins HL,Bell JC

25-0114 was used in Flow cytometry/Cell sorting to investigate the use of Parapoxvirus ovis for the treatment of cancer.

Fri Jun 01 00:00:00 EDT 2012

Efficient capture of infected neutrophils by dendritic cells in the skin inhibits the early anti-leishmania response.

PLoS pathogens

Ribeiro-Gomes FL,Peters NC,Debrabant A,Sacks DL

25-0114 was used in Flow cytometry/Cell sorting to study how exploitation of immunosuppressive effects by L.major following rapid uptake by skin neutrophils allows inhibition of acquired resistance.

Wed Feb 01 00:00:00 EST 2012

A single nucleotide polymorphism in tetherin promotes retrovirus restriction in vivo.

PLoS pathogens

Barrett BS,Smith DS,Li SX,Guo K,Hasenkrug KJ,Santiago ML

25-0114 was used in Flow cytometry/Cell sorting to elucidate the role of the cell surface membrane protein, tetherin, in retroviral spread following retroviral infection.

Mon Jul 09 00:00:00 EDT 2012

CD64 expression distinguishes monocyte-derived and conventional dendritic cells and reveals their distinct role during intramuscular immunization.

Journal of immunology (Baltimore, Md. : 1950)

Langlet C,Tamoutounour S,Henri S,Luche H,Ardouin L,Grégoire C,Malissen B,Guilliams M

25-0114 was used in Flow cytometry/Cell sorting to define the distinct DC subsets that reside in skeletal muscles and identify their migratory counterparts in draining LNs.

Wed Feb 15 00:00:00 EST 2012

CD11c+ cells are required for antigen-induced increase of mast cells in the lung.

Journal of immunology (Baltimore, Md. : 1950)

Dahlin JS,Feinstein R,Cui Y,Heyman B,Hallgren J

25-0114 was used in Flow cytometry/Cell sorting to determine the contribution of Ag-stimulated CD11c(+) cells to the allergic response in asthmatics.

Mon Oct 15 00:00:00 EDT 2012

Novel murine dendritic cell lines: a powerful auxiliary tool for dendritic cell research.

Frontiers in immunology

Fuertes Marraco SA,Grosjean F,Duval A,Rosa M,Lavanchy C,Ashok D,Haller S,Otten LA,Steiner QG,Descombes P,Luber CA,Meissner F,Mann M,Szeles L,Reith W,Acha-Orbea H

25-0114 was used in Flow cytometry/Cell sorting to report the generation of new murine DC lines, named MutuDC, originating from cultures of splenic CD8α conventional DC (cDC) tumours.

Tue Nov 20 00:00:00 EST 2012

Resident cardiac immune cells and expression of the ectonucleotidase enzymes CD39 and CD73 after ischemic injury.

PloS one

Bönner F,Borg N,Burghoff S,Schrader J

25-0114 was used in Flow cytometry/Cell sorting to explore the abundance of CD73 and CD39 on immune cells under control conditions and in response to inflammation.

Thu Aug 30 00:00:00 EDT 2012

Flt3L combined with rapamycin promotes cardiac allograft tolerance by inducing regulatory dendritic cells and allograft autophagy in mice.

PloS one

Xiong A,Duan L,Chen J,Fan Z,Zheng F,Tan Z,Gong F,Fang M

25-0114 was used in Flow cytometry/Cell sorting to investigate the role of Flt3 and Flt3L in immune tolerance, showing that Flt3L combined with rapamycin promotes cardiac allograft tolerance via dendritic cell induction.

Tue Jun 11 00:00:00 EDT 2013

Transmembrane mutations in Toll-like receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation.

Immunity

Mouchess ML,Arpaia N,Souza G,Barbalat R,Ewald SE,Lau L,Barton GM

25-0114 was used in Flow cytometry/Cell sorting to elucidate residues within the TLR9 transmembrane region that confer the requirement for ectodomain proteolysis.

Wed Nov 23 00:00:00 EST 2011

Retinoic acid induces homing of protective T and B cells to the gut after subcutaneous immunization in mice.

The Journal of clinical investigation

Hammerschmidt SI,Friedrichsen M,Boelter J,Lyszkiewicz M,Kremmer E,Pabst O,Förster R

25-0114 was used in Flow cytometry/Cell sorting to investigate the effectiveness of retinoic acid-assisted subcutaneous immunisation as a novel approach to vaccination against enteropathogens.

Mon Aug 01 00:00:00 EDT 2011

Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response.

PLoS pathogens

Smith DS,Guo K,Barrett BS,Heilman KJ,Evans LH,Hasenkrug KJ,Greene WC,Santiago ML

25-0114 was used in Flow cytometry/Cell sorting to indicate that innate Apobec3 restriction promotes NAb responses by maintaining high concentrations of virions with native B cell epitopes.

Sat Oct 01 00:00:00 EDT 2011

The earliest intrathymic precursors of CD8α(+) thymic dendritic cells correspond to myeloid-type double-negative 1c cells.

European journal of immunology

Luche H,Ardouin L,Teo P,See P,Henri S,Merad M,Ginhoux F,Malissen B

25-0114 was used in Flow cytometry/Cell sorting to provide evidence that myeloid-restricted progenitors generate the whole constellation of DCs present in the body, including the thymus.

Mon Aug 01 00:00:00 EDT 2011

The purinergic G protein-coupled receptor 6 inhibits effector T cell activation in allergic pulmonary inflammation.

Journal of immunology (Baltimore, Md. : 1950)

Giannattasio G,Ohta S,Boyce JR,Xing W,Balestrieri B,Boyce JA

25-0114 was used in Flow cytometry/Cell sorting to reveal the role of P2Y(6) receptors for protecting the lung against exuberant allergen-induced pulmonary inflammation.

Mon Aug 01 00:00:00 EDT 2011

Antigen-presenting cells of haematopoietic origin prime cytomegalovirus-specific CD8 T-cells but are not sufficient for driving memory inflation during viral latency.

The Journal of general virology

Seckert CK,Schader SI,Ebert S,Thomas D,Freitag K,Renzaho A,Podlech J,Reddehase MJ,Holtappels R

25-0114 was used in Flow cytometry/Cell sorting to investigate the role of bone marrow-derived professional antigen-presenting cells in CD8 T-cell priming and memory to murine cytomegalovirus.

Thu Sep 01 00:00:00 EDT 2011

Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1.

PloS one

Tulone C,Sponaas AM,Raiber EA,Tabor AB,Langhorne J,Chain BM

25-0114 was used in Flow cytometry/Cell sorting to investigate the contributions of cathepsins D and E in generating Merozoite Surface Protein 1 CD4 T-cell epitopes for presentation.

Fri Feb 24 00:00:00 EST 2012

IgE immune complexes stimulate an increase in lung mast cell progenitors in a mouse model of allergic airway inflammation.

PloS one

Dahlin JS,Ivarsson MA,Heyman B,Hallgren J

25-0114 was used in Flow cytometry/Cell sorting to investigate whether formation of IgE immune complexes in the lungs of sensitised mice increased the migration of mast cell progenitors.

Mon Oct 17 00:00:00 EDT 2011

In vivo requirement for Atg5 in antigen presentation by dendritic cells.

Immunity

Lee HK,Mattei LM,Steinberg BE,Alberts P,Lee YH,Chervonsky A,Mizushima N,Grinstein S,Iwasaki A

25-0114 was used in Flow cytometry/Cell sorting to investigate how dendritic cells utilise autophagic machinery to optimally present extracellular microbial antigens for MHC II molecules.

Fri Feb 26 00:00:00 EST 2010

Negative regulation of autoimmune demyelination by the inhibitory receptor CLM-1.

The Journal of experimental medicine

Xi H,Katschke KJ,Helmy KY,Wark PA,Kljavin N,Clark H,Eastham-Anderson J,Shek T,Roose-Girma M,Ghilardi N,van Lookeren Campagne M

25-0114 was used in Immunohistochemistry to identify CLM-1 as a negative regulator of myeloid effector cells in autoimmune demyelination.

Mon Jan 18 00:00:00 EST 2010

B cell depletion reduces the development of atherosclerosis in mice.

The Journal of experimental medicine

Ait-Oufella H,Herbin O,Bouaziz JD,Binder CJ,Uyttenhove C,Laurans L,Taleb S,Van Vré E,Esposito B,Vilar J,Sirvent J,Van Snick J,Tedgui A,Tedder TF,Mallat Z

25-0114 was used in Flow cytometry/Cell sorting to challenge the current paradigm that B cell activation plays an overall protective role in atherogenesis, and identify new antiatherogenic strategies based on B cell modulation.

Mon Aug 02 00:00:00 EDT 2010

Antigen-specific immunity and cross-priming by epithelial ovarian carcinoma-induced CD11b(+)Gr-1(+) cells.

Journal of immunology (Baltimore, Md. : 1950)

Tomihara K,Guo M,Shin T,Sun X,Ludwig SM,Brumlik MJ,Zhang B,Curiel TJ,Shin T

25-0114 was used in Flow cytometry/Cell sorting to investigate CD11b(+)Gr-1(+) cells found in epithelial ovarian cancer-bearing mice, which are induced by ovarian cancer cells and undergo antigen-specific immunity and cross-priming.

Tue Jun 01 00:00:00 EDT 2010

Group V secretory phospholipase A2 reveals its role in house dust mite-induced allergic pulmonary inflammation by regulation of dendritic cell function.

Journal of immunology (Baltimore, Md. : 1950)

Giannattasio G,Fujioka D,Xing W,Katz HR,Boyce JA,Balestrieri B

25-0114 was used in Flow cytometry/Cell sorting to demonstrate the role of group V secretory phospholipase A(2) in antigen presenting cells following infection with the house dust mite, Dermatophagoides farinae.

Fri Oct 01 00:00:00 EDT 2010

Virulence of Toxoplasma gondii is associated with distinct dendritic cell responses and reduced numbers of activated CD8+ T cells.

Journal of immunology (Baltimore, Md. : 1950)

Tait ED,Jordan KA,Dupont CD,Harris TH,Gregg B,Wilson EH,Pepper M,Dzierszinski F,Roos DS,Hunter CA

25-0114 was used in Flow cytometry/Cell sorting to show the dendritic cell response to T.gondii alters levels of CD8+ T cells which ultimately determine the outcome of infection.

Sun Aug 01 00:00:00 EDT 2010

Magnetic nanoparticles for imaging dendritic cells.

Magnetic resonance in medicine

Kobukai S,Baheza R,Cobb JG,Virostko J,Xie J,Gillman A,Koktysh D,Kerns D,Does M,Gore JC,Pham W

25-0114 was used in Flow cytometry/Cell sorting to develop magnetic nanoparticles for imaging dendritic cells.

Sat May 01 00:00:00 EDT 2010

Magnetic nanoparticles for imaging dendritic cells.

Magnetic resonance in medicine

Kobukai S,Baheza R,Cobb JG,Virostko J,Xie J,Gillman A,Koktysh D,Kerns D,Does M,Gore JC,Pham W

25-0114 was used in Flow cytometry/Cell sorting to develop magnetic nanoparticles for imaging dendritic cells.

Sat May 01 00:00:00 EDT 2010

Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection.

The Journal of experimental medicine

Lee HK,Zamora M,Linehan MM,Iijima N,Gonzalez D,Haberman A,Iwasaki A

25-0114 was used in Flow cytometry/Cell sorting to show that migrant and resident dendritic cells play an important role in priming CD8 and CD4 T cell responses, and their relative importance depends on the mode of infection in vivo.

Mon Feb 16 00:00:00 EST 2009

The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies.

Cancer research

Ozao-Choy J,Ma G,Kao J,Wang GX,Meseck M,Sung M,Schwartz M,Divino CM,Pan PY,Chen SH

25-0114 was used in Flow cytometry/Cell sorting to suggest that sunitinib can be used to reverse immune suppression and as a potentially useful adjunct for enhancing the efficacy of immune-based cancer therapy for advanced malignancies.

Sun Mar 15 00:00:00 EDT 2009

Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.

Journal of immunology (Baltimore, Md. : 1950)

Hamada H,Garcia-Hernandez Mde L,Reome JB,Misra SK,Strutt TM,McKinstry KK,Cooper AM,Swain SL,Dutton RW

25-0114 was used in Flow cytometry/Cell sorting to study the role of Tc17 cells in influenza infection, showing that they protect against lethality.

Sun Mar 15 00:00:00 EDT 2009

Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70.

Journal of immunology (Baltimore, Md. : 1950)

Zietara N,Łyszkiewicz M,Gekara N,Puchałka J,Dos Santos VA,Hunt CR,Pandita TK,Lienenklaus S,Weiss S

25-0114 was used in Flow cytometry/Cell sorting to investigate the role of low level production of IFN, showing that its absence impairs antigen presentation capacity of splenic dendritic cells.

Wed Jul 15 00:00:00 EDT 2009

Dendritic cells matured by inflammation induce CD86-dependent priming of naive CD8+ T cells in the absence of their cognate peptide antigen.

Journal of immunology (Baltimore, Md. : 1950)

Maroof A,Beattie L,Kirby A,Coles M,Kaye PM

25-0114 was used in Flow cytometry/Cell sorting to study how inflammation-matured DCs can induce Ag-independent T cell proliferation.

Tue Dec 01 00:00:00 EST 2009

Amplification of autoimmune response through induction of dendritic cell maturation in inflamed tissues.

Journal of immunology (Baltimore, Md. : 1950)

Melli K,Friedman RS,Martin AE,Finger EB,Miao G,Szot GL,Krummel MF,Tang Q

25-0114 was used in Flow cytometry/Cell sorting to investigate T cell induction of intra-islet dendritic cell maturation during the progression of type 1 diabetes.

Sun Mar 01 00:00:00 EST 2009

Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo.

The Journal of experimental medicine

Ohteki T,Tada H,Ishida K,Sato T,Maki C,Yamada T,Hamuro J,Koyasu S

Mon Oct 02 00:00:00 EDT 2006

The existence of CD11c+ sentinel and F4/80+ interstitial dendritic cells in dental pulp and their dynamics and functional properties.

International immunology

Zhang J,Kawashima N,Suda H,Nakano Y,Takano Y,Azuma M

Fri Sep 01 00:00:00 EDT 2006

Bioinformatics

Protein Aliases: CD11 antigen-like family member C; CD11c; CD11C (p150) alpha polypeptide; complement receptor 4; Integrin alpha-X; integrin aX; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95

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Gene Aliases: AI449405; Cd11c; Cr4; Itgax; N418

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UniProt ID: (Mouse) Q9QXH4

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Entrez Gene ID: (Mouse) 16411

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Function(s)

metal ion binding integrin

Process(es)

cell adhesion integrin-mediated signaling pathway heterotypic cell-cell adhesion activated T cell proliferation defense response to virus positive regulation of protein targeting to mitochondrion

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CD11c Monoclonal Antibody (N418), PE-Cyanine7, eBioscience™

CD11c Antibody (25-0114-82) in Flow

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25-0114-82

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