Invitrogen

CD11c Monoclonal Antibody (N418), PE-eFluor™ 610, eBioscience™

FIGURE: 1 / 99

CD11c Antibody (61-0114-82) in Flow

Staining of C57Bl/6 splenocytes with Anti-Human/Mouse CD45R (B220) FITC (Product # 11-0452-82) and 0.125 µg of Armenian Hamster IgG Isotype Control PE-eFluor® 610 (Product # 61-4888-82) (left) or 0.125 µg of Anti-Mouse CD11c PE-eFluor® 610 (right). Total viable cells, as determined by Propidium Iodide Staining Solution (Product # 00-5990-50), were used for analysis.

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Product Details

61-0114-82

Applications

Tested Dilution

Publications

Immunohistochemistry (Frozen) (IHC (F))

View 3 publications 3 publications

Flow Cytometry (Flow)

0.25 µg/test

View 116 publications 116 publications

Product Specifications

Species Reactivity

Mouse

Published species

Human, Mouse

Host/Isotype

Armenian hamster / IgG

Recommended Isotype Control

Armenian Hamster IgG Isotype Control (eBio299Arm), PE-eFluor™ 610, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

N418

Conjugate

PE-eFluor™ 610 PE-eFluor™ 610 PE-eFluor™ 610

Excitation/Emission Max

565/606 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2574530

Product Specific Information

Description: The N418 monoclonal antibody reacts with mouse CD11c, the integrin alpha X. CD11c non-covalently associates with beta 2 integrin to form the CD11c/CD18 heterodimer. CD11c is expressed by dendritic cells, a subset of Intestinal Intraepithelial Lymphocytes (IEL) and some activated T cells. CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. N418 binds to CD11c on splenic dendritic cells in the T-dependent areas of mouse spleen and precipitates a 150, 90 kDa heterodimer.

Applications Reported: This N418 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This N418 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

PE-eFluor® 610 can be excited with laser lines from 488-561 nm and emits at 607 nm. We recommend using a 610/20 band pass filter (equivalent to PE-Texas Red®). Please make sure that your instrument is capable of detecting this fluorochome.

Light sensitivity: This tandem dye is sensitive to photo-induced oxidation. Please protect this vial and stained samples from light.

Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-8222) (100 µL of cell sample + 100 µL of IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product # 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.

Excitation: 488-561 nm; Emission: 607 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

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61-0114-82 was used in Flow cytometry/Cell sorting to identify OTULIN as a major anti-apoptotic protein in the intestinal epithelium and provide mechanistic insights into how OTULIN deficiency drives gastrointestinal inflammation in ORAS patients.

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Outer Membrane Vesicle-Coated Nanoparticle Vaccine Protects Against Acinetobacter baumannii Pneumonia and Sepsis.

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Bjanes E,Zhou J,Qayum T,Krishnan N,Zurich RH,Menon ND,Hoffman A,Fang RH,Zhang L,Nizet V

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CD11c⁺ microglia promote white matter repair after ischemic stroke.

Cell death & disease

Jia J,Zheng L,Ye L,Chen J,Shu S,Xu S,Bao X,Xia S,Liu R,Xu Y,Zhang M

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Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.

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P. gingivalis Infection Upregulates PD-L1 Expression on Dendritic Cells, Suppresses CD8+ T-cell Responses, and Aggravates Oral Cancer.

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Inhibition of Macrophage-Specific CHIT1 as an Approach to Treat Airway Remodeling in Severe Asthma.

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Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain.

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Interferon-γ Stimulates Interleukin-27 Derived from Dendritic Cells to Regulate Th9 Differentiation through STAT1/3 Pathway.

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Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

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Neutrophil-dendritic cell interaction plays an important role in live attenuated Leishmania vaccine induced immunity.

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Bhattacharya P,Ismail N,Saxena A,Gannavaram S,Dey R,Oljuskin T,Akue A,Takeda K,Yu J,Karmakar S,Dagur PK,McCoy JP,Nakhasi HL

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Nucleolin Therapeutic Targeting Decreases Pancreatic Cancer Immunosuppression.

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61-0114-82 was used in Flow cytometry/Cell sorting to identify prostaglandin E2 as a factor within the aged lung that compromise host defense to IAV by impairing the proliferation of alveolar macrophages.

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Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells.

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Michelson DA,Hase K,Kaisho T,Benoist C,Mathis D

61-0114-82 was used in Flow cytometry/Cell sorting to uncover signatures of lineage-defining transcription factors (TFs) for skin, lung, liver, and intestinal cells-including Grhl, FoxA, FoxJ1, Hnf4, Sox8, and SpiB-in distinct mTEC subtypes.

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Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin.

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Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity.

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British journal of pharmacology

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RIG-I Promotes Cell Death in Hepatocellular Carcinoma by Inducing M1 Polarization of Perineal Macrophages Through the RIG-I/MAVS/NF-κB Pathway.

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Sun Apr 17 00:00:00 EDT 2022

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Nature communications

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eLife

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CD103⁺ cDC1 and endogenous CD8⁺ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.

Nature communications

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Wed Dec 02 00:00:00 EST 2020

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.

JCI insight

Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A

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Thu Aug 20 00:00:00 EDT 2020

Hepatocytes trap and silence coxsackieviruses, protecting against systemic disease in mice.

Communications biology

Kimura T,Flynn CT,Whitton JL

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Fri Oct 16 00:00:00 EDT 2020

CNS Immune Profiling in a Dengue Virus-Infected Immunocompetent Outbred ICR Mice Strain.

Frontiers in cellular and infection microbiology

Shen TJ,Chen CL,Jhan MK,Tseng PC,Lin CF

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Thu Jun 17 00:00:00 EDT 2021

Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3.

Cell metabolism

Hall JA,Ramachandran D,Roh HC,DiSpirito JR,Belchior T,Zushin PH,Palmer C,Hong S,Mina AI,Liu B,Deng Z,Aryal P,Jacobs C,Tenen D,Brown CW,Charles JF,Shulman GI,Kahn BB,Tsai LTY,Rosen ED,Spiegelman BM,Banks AS

61-0114-82 was used in Flow cytometry/Cell sorting to highlight the diabetogenic role of PPARγ S273 phosphorylation and focus attention on a putative target, Gdf3.

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Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity.

Nature communications

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Fri Jul 24 00:00:00 EDT 2020

Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response.

Nature cancer

Poillet-Perez L,Sharp DW,Yang Y,Laddha SV,Ibrahim M,Bommareddy PK,Hu ZS,Vieth J,Haas M,Bosenberg MW,Rabinowitz JD,Cao J,Guan JL,Ganesan S,Chan CS,Mehnert JM,Lattime EC,White E

61-0114-82 was used in Flow Cytometry to study autophagy promotion of tumor immune tolerance in regulating T-cell function and limiting interferon gene stimulation.

Tue Sep 01 00:00:00 EDT 2020

OTULIN Prevents Liver Inflammation and Hepatocellular Carcinoma by Inhibiting FADD- and RIPK1 Kinase-Mediated Hepatocyte Apoptosis.

Cell reports

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61-0114 was used in Flow cytometry/Cell sorting to investigate the effects of ablation of OTILON in liver parenchymal cells on the liver and inflammation using a mouse model.

Tue Feb 18 00:00:00 EST 2020

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche.

Immunity

Bonnardel J,T'Jonck W,Gaublomme D,Browaeys R,Scott CL,Martens L,Vanneste B,De Prijck S,Nedospasov SA,Kremer A,Van Hamme E,Borghgraef P,Toussaint W,De Bleser P,Mannaerts I,Beschin A,van Grunsven LA,Lambrecht BN,Taghon T,Lippens S,Elewaut D,Saeys Y,Guilliams M

61-0114-82 was used in Flow Cytometry to show that the Kupffer cell niche is composed of stellate cells, hepatocytes, and endothelial cells that together imprint the liver-specific macrophage identity.

Tue Oct 15 00:00:00 EDT 2019

An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development.

Nature immunology

Bagadia P,Huang X,Liu TT,Durai V,Grajales-Reyes GE,Nitschké M,Modrusan Z,Granja JM,Satpathy AT,Briseño CG,Gargaro M,Iwata A,Kim S,Chang HY,Shaw AS,Murphy TL,Murphy KM

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cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.

The Journal of clinical investigation

Wang Z,Chen J,Hu J,Zhang H,Xu F,He W,Wang X,Li M,Lu W,Zeng G,Zhou P,Huang P,Chen S,Li W,Xia LP,Xia X

61-0114 was used in Flow cytometry/Cell sorting to show that teniposide could trigger tumor immunogenicity and enable a potential chemoimmunotherapeutic approach to potentiating the therapeutic efficacy of anti-PD1 immunotherapy.

Tue Aug 13 00:00:00 EDT 2019

CD1d highly expressed on DCs reduces lung tumor burden by enhancing antitumor immunity.

Oncology reports

Li Y,Zhao C,Liu J,Lu Z,Lu M,Gu J,Liu R

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Wed May 01 00:00:00 EDT 2019

Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.

Frontiers in immunology

Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Wed Oct 14 00:00:00 EDT 2020

Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity.

Nature metabolism

Seo JB,Riopel M,Cabrales P,Huh JY,Bandyopadhyay GK,Andreyev AY,Murphy AN,Beeman SC,Smith GI,Klein S,Lee YS,Olefsky JM

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2019

CD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality.

Nature communications

Casulli J,Fife ME,Houston SA,Rossi S,Dow J,Williamson ED,Clark GC,Hussell T,D'Elia RV,Travis MA

61-0114 was used in Flow cytometry/Cell sorting to investigate the role of the CD200 receptor in the antimicrobial properties of neutrophils in the lungs of mice.

Thu May 09 00:00:00 EDT 2019

Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.

Cell

Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Thu Jan 25 00:00:00 EST 2018

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control.

Cell

Böttcher JP,Bonavita E,Chakravarty P,Blees H,Cabeza-Cabrerizo M,Sammicheli S,Rogers NC,Sahai E,Zelenay S,Reis e Sousa C

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Thu Feb 22 00:00:00 EST 2018

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Cell

Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Thu Jun 28 00:00:00 EDT 2018

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages.

Immunity

Scott CL,T'Jonck W,Martens L,Todorov H,Sichien D,Soen B,Bonnardel J,De Prijck S,Vandamme N,Cannoodt R,Saelens W,Vanneste B,Toussaint W,De Bleser P,Takahashi N,Vandenabeele P,Henri S,Pridans C,Hume DA,Lambrecht BN,De Baetselier P,Milling SWF,Van Ginderachter JA,Malissen B,Berx G,Beschin A,Saeys Y,Guilliams M

61-0114 was used in Flow cytometry/Cell sorting to demonstrate that ZEB2 expression is required in macrophages to preserve their tissue-specific identities.

Tue Aug 21 00:00:00 EDT 2018

Insulin resistance causes inflammation in adipose tissue.

The Journal of clinical investigation

Shimobayashi M,Albert V,Woelnerhanssen B,Frei IC,Weissenberger D,Meyer-Gerspach AC,Clement N,Moes S,Colombi M,Meier JA,Swierczynska MM,Jenö P,Beglinger C,Peterli R,Hall MN

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Mon Apr 02 00:00:00 EDT 2018

Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease.

The Journal of clinical investigation

Tsantikos E,Lau M,Castelino CM,Maxwell MJ,Passey SL,Hansen MJ,McGregor NE,Sims NA,Steinfort DP,Irving LB,Anderson GP,Hibbs ML

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Fri Jun 01 00:00:00 EDT 2018

Photodynamic therapy reduces the inhibitory effect of osteosarcoma cells on dendritic cells by upregulating HSP70.

Oncology letters

Zhang F,Zhu Y,Fan G,Hu S

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Mon Oct 01 00:00:00 EDT 2018

FACS isolation of live mouse eosinophils at high purity via a protocol that does not target Siglec F.

Journal of immunological methods

Geslewitz WE,Percopo CM,Rosenberg HF

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Thu Mar 01 00:00:00 EST 2018

Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung.

Frontiers in physiology

Lim D,Kim W,Lee C,Bae H,Kim J

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Characterization of Multiple Cytokine Combinations and TGF-β on Differentiation and Functions of Myeloid-Derived Suppressor Cells.

International journal of molecular sciences

Lee CR,Lee W,Cho SK,Park SG

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Thu Mar 15 00:00:00 EDT 2018

RIG-I antiviral signaling drives interleukin-23 production and psoriasis-like skin disease.

EMBO molecular medicine

Zhu H,Lou F,Yin Q,Gao Y,Sun Y,Bai J,Xu Z,Liu Z,Cai W,Ke F,Zhang L,Zhou H,Wang H,Wang G,Chen X,Zhang H,Wang Z,Ginhoux F,Lu C,Su B,Wang H

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

FcεRI γ-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells.

Frontiers in immunology

Pan YG,Yu YL,Lin CC,Lanier LL,Chu CL

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

Cornea lymphatics drive the CD8⁺ T-cell response to herpes simplex virus-1.

Immunology and cell biology

Gurung HR,Carr MM,Carr DJ

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2017

Discrimination of the heterogeneity of bone marrow‑derived dendritic cells.

Molecular medicine reports

Wang J,Dai X,Hsu C,Ming C,He Y,Zhang J,Wei L,Zhou P,Wang CY,Yang J,Gong N

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Wed Nov 01 00:00:00 EDT 2017

The Second-Generation PGI2 Analogue Treprostinil Fails to Chemoprevent Tumors in a Murine Lung Adenocarcinoma Model.

Cancer prevention research (Philadelphia, Pa.)

Dwyer-Nield L,Hickey GA,Friedman M,Choo K,McArthur DG,Tennis MA,New ML,Geraci M,Keith RL

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Wed Nov 01 00:00:00 EDT 2017

Calreticulin is an effective immunologic adjuvant to tumor-associated antigens.

Experimental and therapeutic medicine

Wang J,Gao ZP,Qin S,Liu CB,Zou LL

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2017

PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy.

Scientific reports

Gao S,Li C,Zhu Y,Wang Y,Sui A,Zhong Y,Xie B,Shen X

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Fri Feb 17 00:00:00 EST 2017

BEX1 is an RNA-dependent mediator of cardiomyopathy.

Nature communications

Accornero F,Schips TG,Petrosino JM,Gu SQ,Kanisicak O,van Berlo JH,Molkentin JD

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Thu Nov 30 00:00:00 EST 2017

Commensal microbiota maintains alveolar macrophages with a low level of CCL24 production to generate anti-metastatic tumor activity.

Scientific reports

Cheng M,Chen Y,Wang L,Chen W,Yang L,Shen G,Xu T,Shen G,Tian Z,Hu S

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Mon Aug 07 00:00:00 EDT 2017

Single-cell tracking of flavivirus RNA uncovers species-specific interactions with the immune system dictating disease outcome.

Nature communications

Douam F,Hrebikova G,Albrecht YE,Sellau J,Sharon Y,Ding Q,Ploss A

61-0114 was used in Flow cytometry/Cell sorting to demonstrate the tracking of and sense viral RNA at single-cell resolution within complex subsets of the human and murine immune system in different mouse models.

Tue Mar 14 00:00:00 EDT 2017

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Cell

Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Thu Oct 06 00:00:00 EDT 2016

Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression.

The Journal of clinical investigation

Menheniott TR,O'Connor L,Chionh YT,Däbritz J,Scurr M,Rollo BN,Ng GZ,Jacobs S,Catubig A,Kurklu B,Mercer S,Minamoto T,Ong DE,Ferrero RL,Fox JG,Wang TC,Sutton P,Judd LM,Giraud AS

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Fri Apr 01 00:00:00 EDT 2016

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.

Immunology

Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2016

Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice.

Autoimmunity

Haddad CS,Bhattacharya P,Alharshawi K,Marinelarena A,Kumar P,El-Sayed O,Elshabrawy HA,Epstein AL,Prabhakar BS

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

CD80 and CD86 knockdown in dendritic cells regulates Th1/Th2 cytokine production in asthmatic mice.

Experimental and therapeutic medicine

Li JG,DU YM,Yan ZD,Yan J,Zhuansun YX,Chen R,Zhang W,Feng SL,Ran PX

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Tue Mar 01 00:00:00 EST 2016

Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice.

BMC complementary and alternative medicine

Zhang S,Liu X,Mei L,Wang H,Fang F

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Wed Aug 31 00:00:00 EDT 2016

Altered gp130 signalling ameliorates experimental colitis via myeloid cell-specific STAT3 activation and myeloid-derived suppressor cells.

Scientific reports

Däbritz J,Judd LM,Chalinor HV,Menheniott TR,Giraud AS

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Fri Feb 05 00:00:00 EST 2016

Flagellin is a strong vaginal adjuvant of a therapeutic vaccine for genital cancer.

Oncoimmunology

Lee SE,Hong SH,Verma V,Lee YS,Duong TN,Jeong K,Uthaman S,Sung YC,Lee JT,Park IK,Min JJ,Rhee JH

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2016

Thymic exosomes promote the final maturation of thymocytes.

Scientific reports

Lundberg V,Berglund M,Skogberg G,Lindgren S,Lundqvist C,Gudmundsdottir J,Thörn K,Telemo E,Ekwall O

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Tue Nov 08 00:00:00 EST 2016

Epidermal RAF prevents allergic skin disease.

eLife

Raguz J,Jeric I,Niault T,Nowacka JD,Kuzet SE,Rupp C,Fischer I,Biggi S,Borsello T,Baccarini M

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Tue Jul 19 00:00:00 EDT 2016

Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.

Scientific reports

Ochi T,Feng Y,Kitamoto S,Nagao-Kitamoto H,Kuffa P,Atarashi K,Honda K,Teitelbaum DH,Kamada N

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Wed Jun 15 00:00:00 EDT 2016

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis.

Nature medicine

Shankman LS,Gomez D,Cherepanova OA,Salmon M,Alencar GF,Haskins RM,Swiatlowska P,Newman AA,Greene ES,Straub AC,Isakson B,Randolph GJ,Owens GK

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2015

Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection.

Nature

Kimmey JM,Huynh JP,Weiss LA,Park S,Kambal A,Debnath J,Virgin HW,Stallings CL

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Thu Dec 24 00:00:00 EST 2015

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.

Nature biotechnology

Kim J,Li WA,Choi Y,Lewin SA,Verbeke CS,Dranoff G,Mooney DJ

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2015

Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2.

EMBO molecular medicine

Bretscher P,Egger J,Shamshiev A,Trötzmüller M,Köfeler H,Carreira EM,Kopf M,Freigang S

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2015

Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.

Cardiovascular research

Wan W,Liu Q,Lionakis MS,Marino AP,Anderson SA,Swamydas M,Murphy PM

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2015

Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.

Frontiers in immunology

Vogel AJ,Brown DM

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Fri Jul 10 00:00:00 EDT 2015

LynA regulates an inflammation-sensitive signaling checkpoint in macrophages.

eLife

Freedman TS,Tan YX,Skrzypczynska KM,Manz BN,Sjaastad FV,Goodridge HS,Lowell CA,Weiss A

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Fri Oct 30 00:00:00 EDT 2015

The late endosomal adaptor molecule p14 (LAMTOR2) regulates TGFβ1-mediated homeostasis of Langerhans cells.

The Journal of investigative dermatology

Sparber F,Tripp CH,Komenda K,Scheffler JM,Clausen BE,Huber LA,Romani N,Stoitzner P

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2015

Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance.

International journal of obesity (2005)

Khan IM,Perrard XY,Brunner G,Lui H,Sparks LM,Smith SR,Wang X,Shi ZZ,Lewis DE,Wu H,Ballantyne CM

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Sun Nov 01 00:00:00 EDT 2015

A far-red fluorescent probe for flow cytometry and image-based functional studies of xenobiotic sequestering macrophages.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Keswani RK,Yoon GS,Sud S,Stringer KA,Rosania GR

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses.

Human vaccines & immunotherapeutics

Rose AH,Hoffmann FW,Hara JH,Urschitz J,Moisyadi S,Hoffmann PR,Bertino P

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Mon May 16 00:00:00 EDT 2016

Inadequate activation of the HBsAg-specific Th cells by APCs leads to hyporesponsiveness to HBsAg vaccine in B10.S mice.

Human vaccines & immunotherapeutics

Li X,Xu J,Lv Z,Wang J,Sun S,Zhu W,Wang B,He R,Qu D

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Tue Apr 19 00:00:00 EDT 2016

Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway.

Molecular medicine reports

Huang L,Kong Y,Wang J,Sun J,Shi Q,Qiu YH

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-κB Pathway.

BioMed research international

Jin X,Yao T,Zhou Z,Zhu J,Zhang S,Hu W,Shen C

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Fri Mar 18 00:00:00 EDT 2016

Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model.

BioMed research international

Olsen DS,Goar WA,Nichols BA,Bailey KT,Christensen SL,Merriam KR,Reynolds PR,Wilson E,Weber KS,Bridgewater LC

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion.

The Journal of biological chemistry

Pamir N,Liu NC,Irwin A,Becker L,Peng Y,Ronsein GE,Bornfeldt KE,Duffield JS,Heinecke JW

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Fri Jun 05 00:00:00 EDT 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Tue Sep 15 00:00:00 EDT 2015

Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice.

Nature communications

Singh NK,Kotla S,Dyukova E,Traylor JG,Orr AW,Chernoff J,Marion TN,Rao GN

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Wed Jun 24 00:00:00 EDT 2015

Isolation of Splenic Dendritic Cells Using Fluorescence-activated Cell Sorting.

Bio-protocol

Tavernier SJ,Osorio F,Janssens S,Lambrecht BN

61-0114 was used in Flow cytometry/Cell sorting to describe a protocol for the isolation of specific DC subsets from mouse spleens for experimental use ex vivo.

Thu Mar 05 00:00:00 EST 2015

Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes.

Nature medicine

Clatworthy MR,Aronin CE,Mathews RJ,Morgan NY,Smith KG,Germain RN

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Mon Dec 01 00:00:00 EST 2014

High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity.

Nature

Schulz MD,Atay C,Heringer J,Romrig FK,Schwitalla S,Aydin B,Ziegler PK,Varga J,Reindl W,Pommerenke C,Salinas-Riester G,Böck A,Alpert C,Blaut M,Polson SC,Brandl L,Kirchner T,Greten FR,Polson SW,Arkan MC

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Thu Oct 23 00:00:00 EDT 2014

A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking β-glucans.

PloS one

Dong B,Li D,Li R,Chen SC,Liu W,Liu W,Chen L,Chen Y,Zhang X,Tong Z,Xia Y,Xia P,Wang Y,Duan Y

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2015

P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica.

PloS one

Monção-Ribeiro LC,Faffe DS,Santana PT,Vieira FS,da Graça CL,Marques-da-Silva C,Machado MN,Caruso-Neves C,Zin WA,Borojevic R,Takiya CM,Coutinho-Silva R

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Thu Sep 17 00:00:00 EDT 2015

Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.

Cardiovascular research

Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2013

CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium.

Mucosal immunology

Manta C,Heupel E,Radulovic K,Rossini V,Garbi N,Riedel CU,Niess JH

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2013

Neutralization of TSLP inhibits airway remodeling in a murine model of allergic asthma induced by chronic exposure to house dust mite.

PloS one

Chen ZG,Zhang TT,Li HT,Chen FH,Zou XL,Ji JZ,Chen H

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Tue Aug 20 00:00:00 EDT 2013

Alum increases antigen uptake, reduces antigen degradation and sustains antigen presentation by DCs in vitro.

Immunology letters

Ghimire TR,Benson RA,Garside P,Brewer JM

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Sat Sep 01 00:00:00 EDT 2012

Differential gene expression in mice infected with distinct Toxoplasma strains.

Infection and immunity

Hill RD,Gouffon JS,Saxton AM,Su C

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Thu Mar 01 00:00:00 EST 2012

PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection.

PloS one

Hemmers S,Teijaro JR,Arandjelovic S,Mowen KA

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Tue Nov 15 00:00:00 EST 2011

Moderate oxygen augments lipopolysaccharide-induced lung injury in mice.

American journal of physiology. Lung cellular and molecular physiology

Aggarwal NR,D'Alessio FR,Tsushima K,Files DC,Damarla M,Sidhaye VK,Fraig MM,Polotsky VY,King LS

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Mon Mar 01 00:00:00 EST 2010

Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine.

Gastroenterology

Shang L,Thirunarayanan N,Viejo-Borbolla A,Martin AP,Bogunovic M,Marchesi F,Unkeless JC,Ho Y,Furtado GC,Alcami A,Merad M,Mayer L,Lira SA

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2009

Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism.

Molecular therapy : the journal of the American Society of Gene Therapy

Devey L,Ferenbach D,Mohr E,Sangster K,Bellamy CO,Hughes J,Wigmore SJ

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2009

Combination of all-trans retinoic acid and a human papillomavirus therapeutic vaccine suppresses the number and function of immature myeloid cells and enhances antitumor immunity.

Cancer science

Song X,Ye D,Liu B,Cui J,Zhao X,Yi L,Liang J,Song J,Zhang Z,Zhao Q

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Sun Feb 01 00:00:00 EST 2009

TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.

Cellular immunology

Drage MG,Pecora ND,Hise AG,Febbraio M,Silverstein RL,Golenbock DT,Boom WH,Harding CV

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Fri Jun 12 00:00:00 EDT 2009

Mycobacterium bovis BCG decreases MHC-II expression in vivo on murine lung macrophages and dendritic cells during aerosol infection.

Cellular immunology

Pecora ND,Fulton SA,Reba SM,Drage MG,Simmons DP,Urankar-Nagy NJ,Boom WH,Harding CV

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Fri Jan 02 00:00:00 EST 2009

The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci.

International journal of experimental pathology

DuPré SA,Redelman D,Hunter KW

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Mon Oct 01 00:00:00 EDT 2007

Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo.

The Journal of experimental medicine

Ohteki T,Tada H,Ishida K,Sato T,Maki C,Yamada T,Hamuro J,Koyasu S

Mon Oct 02 00:00:00 EDT 2006

Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells.

Journal of virology

Xin KQ,Mizukami H,Urabe M,Toda Y,Shinoda K,Yoshida A,Oomura K,Kojima Y,Ichino M,Klinman D,Ozawa K,Okuda K

Published figure using CD11c monoclonal antibody (Product # 61-0114-82) in Flow Cytometry

Fri Dec 01 00:00:00 EST 2006

The existence of CD11c+ sentinel and F4/80+ interstitial dendritic cells in dental pulp and their dynamics and functional properties.

International immunology

Zhang J,Kawashima N,Suda H,Nakano Y,Takano Y,Azuma M

Fri Sep 01 00:00:00 EDT 2006

Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection.

Cancer research

Guiducci C,Vicari AP,Sangaletti S,Trinchieri G,Colombo MP

Fri Apr 15 00:00:00 EDT 2005

Bioinformatics

Protein Aliases: CD11 antigen-like family member C; CD11c; CD11C (p150) alpha polypeptide; complement receptor 4; Integrin alpha-X; integrin aX; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95

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Gene Aliases: AI449405; Cd11c; Cr4; Itgax; N418

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UniProt ID: (Mouse) Q9QXH4

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Entrez Gene ID: (Mouse) 16411

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Function(s)

metal ion binding integrin

Process(es)

cell adhesion integrin-mediated signaling pathway heterotypic cell-cell adhesion activated T cell proliferation defense response to virus positive regulation of protein targeting to mitochondrion

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CD11c Monoclonal Antibody (N418), PE-eFluor™ 610, eBioscience™

CD11c Antibody (61-0114-82) in Flow

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61-0114-82

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