Invitrogen

CD11c Monoclonal Antibody (N418), Super Bright™ 436, eBioscience™

FIGURE: 1 / 48

CD11c Antibody (62-0114-82) in Flow

C57BL/6 mouse splenocytes were stained with CD45R (B220) Monoclonal Antibody, FITC (Product # 11-0452-82) and 0.25 µg of Armenian Hamster IgG Isotype Control, Super Bright 436 (Product # 62-4888-82) (left) or 0.25 µg of CD11c Monoclonal Antibody, Super Bright 436 (right). Total viable cells were used for analysis.

CD11c Antibody in Immunohistochemistry (IHC)

CD11c Antibody in Immunocytochemistry (ICC/IF)

CD11c Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)

Product Image Gallery

Product Details

62-0114-82

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 8 publications 8 publications

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Flow Cytometry (Flow)

0.5 µg/test

View 43 publications 43 publications

Product Specifications

Species Reactivity

Mouse

Published species

Not Applicable

Host/Isotype

Armenian hamster / IgG

Recommended Isotype Control

Armenian Hamster IgG Isotype Control (eBio299Arm), Super Bright™ 436, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

N418

Conjugate

Super Bright™ 436 Super Bright™ 436 Super Bright™ 436

Excitation/Emission Max

413/431 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2, with BSA

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2722928

Product Specific Information

Description: The N418 monoclonal antibody reacts with mouse CD11c, the integrin alpha X. CD11c non-covalently associates with beta 2 integrin to form the CD11c/CD18 heterodimer. CD11c is expressed by dendritic cells, a subset of Intestinal Intraepithelial Lymphocytes (IEL) and some activated T cells. CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. N418 binds to CD11c on splenic dendritic cells in the T-dependent areas of mouse spleen and precipitates a 150, 90 kDa heterodimer.

Applications Reported: This N418 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This N418 antibody has been tested by flow cytometric analysis of mouse splenocytes. This may be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Super Bright 436 can be excited with the violet laser line (405 nm) and emits at 436 nm. We recommend using a 450/50 bandpass filter, or equivalent. Please make sure that your instrument is capable of detecting this fluorochrome.

When using two or more Super Bright dye-conjugated antibodies in a staining panel, it is recommended to use Super Bright Complete Staining Buffer (Product # SB-4401) to minimize any non-specific polymer interactions. Please refer to the datasheet for Super Bright Staining Buffer for more information.

Excitation: 405 nm; Emission: 436 nm; Laser: Violet Laser

Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company.

Target Information

CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity.

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P2X7 receptor modulates inflammatory and functional pulmonary changes induced by silica.

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Leptin receptor is expressed in thymus medulla and leptin protects against thymic remodeling during endotoxemia-induced thymus involution.

The Journal of endocrinology

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Published figure using CD11c monoclonal antibody (Product # 62-0114-82) in Immunocytochemistry

Thu Oct 01 00:00:00 EDT 2009

Bioinformatics

Protein Aliases: CD11 antigen-like family member C; CD11c; CD11C (p150) alpha polypeptide; complement receptor 4; Integrin alpha-X; integrin aX; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95

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Gene Aliases: AI449405; Cd11c; Cr4; Itgax; N418

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UniProt ID: (Mouse) Q9QXH4

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Entrez Gene ID: (Mouse) 16411

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Function(s)

metal ion binding integrin

Process(es)

cell adhesion integrin-mediated signaling pathway heterotypic cell-cell adhesion activated T cell proliferation defense response to virus positive regulation of protein targeting to mitochondrion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD11c Monoclonal Antibody (N418), Super Bright™ 436, eBioscience™

CD11c Antibody (62-0114-82) in Flow

Product Details

62-0114-82

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

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