Product References
Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis.
iScience
Zhou J,Wang H,Shu T,Wang J,Yang W,Li J,Ding L,Liu M,Sun H,Wong J,Lai PB,Tsang SW,Ward SE,Chow KL,Sung JJ,Sze-Lok Cheng A
47-0114-82 was used in Flow Cytometry to demonstrated that cell cycle-related kinase (CCRK) is upregulated in myeloid cells in tumor-bearing mice and in patients with hepatocellular carcinoma.
Fri Oct 20 00:00:00 EDT 2023
Immunomodulatory Role of Surfactant Protein-D in a Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Model.
Frontiers in immunology
Ganguly K,Kishore U,Metkari SM,Madan T
47-0114-82 was used in flow cytometry to evaluate the expression of Surfactant protein D in early and advanced stages of Prostate cancer using transgenic adenocarcinoma of mouse prostate (TRAMP) model.
Tue Jul 26 00:00:00 EDT 2022
Mechanisms of CD40-dependent cDC1 licensing beyond costimulation.
Nature immunology
Wu R,Ohara RA,Jo S,Liu TT,Ferris ST,Ou F,Kim S,Theisen DJ,Anderson DA,Wong BW,Gershon T,Schreiber RD,Murphy TL,Murphy KM
47-0114-82 was used in Flow Cytometry to identify CD40-induced genes in cDC1s, including Cd70, Tnfsf9, Ptgs2 and Bcl2l1, and examined their contributions to anti-tumor immunity.
Tue Nov 01 00:00:00 EDT 2022
Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication.
Immunity
Gargaro M,Scalisi G,Manni G,Briseño CG,Bagadia P,Durai V,Theisen DJ,Kim S,Castelli M,Xu CA,Meyer Zu Hörste G,Servillo G,Della Fazia MA,Mencarelli G,Ricciuti D,Padiglioni E,Giacchè N,Colliva C,Pellicciari R,Calvitti M,Zelante T,Fuchs D,Orabona C,Boon L,Bessede A,Colonna M,Puccetti P,Murphy TL,Murphy KM,Fallarino F
47-0114-82 was used in Flow cytometry/Cell sorting to represent a potential therapeutic target in treating autoimmune demyelinating diseases.
Tue Jun 14 00:00:00 EDT 2022
Murine model of colonization with fungal pathogen Candida auris to explore skin tropism, host risk factors and therapeutic strategies.
Cell host & microbe
Huang X,Hurabielle C,Drummond RA,Bouladoux N,Desai JV,Sim CK,Belkaid Y,Lionakis MS,Segre JA
47-0114-82 was used in Flow Cytometry to develop a murine skin topical exposure model for C. auris to dissect risk factors for colonization and to test interventions that might protect patients.
Wed Feb 10 00:00:00 EST 2021
A booster dose enhances immunogenicity of the COVID-19 vaccine candidate ChAdOx1 nCoV-19 in aged mice.
Med (New York, N.Y.)
Silva-Cayetano A,Foster WS,Innocentin S,Belij-Rammerstorfer S,Spencer AJ,Burton OT,Fra-Bidó S,Le Lee J,Thakur N,Conceicao C,Wright D,Barrett J,Evans-Bailey N,Noble C,Bailey D,Liston A,Gilbert SC,Lambe T,Linterman MA
47-0114-82 was used in Flow Cytometry to show that ChAdOx1 nCoV-19 induces both cellular and humoral immunity in adult and aged mice and suggest a prime-boost strategy is a rational approach to enhance immunogenicity in older persons.
Fri Mar 12 00:00:00 EST 2021
Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity.
Cell
Giampazolias E,Schulz O,Lim KHJ,Rogers NC,Chakravarty P,Srinivasan N,Gordon O,Cardoso A,Buck MD,Poirier EZ,Canton J,Zelenay S,Sammicheli S,Moncaut N,Varsani-Brown S,Rosewell I,Reis e Sousa C
47-0114-82 was used in Flow Cytometry to reveal a natural barrier to cross-presentation of cancer antigens that dampens anti-tumor CD8+ T cell responses.
Thu Jul 22 00:00:00 EDT 2021
Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging.
The journals of gerontology. Series A, Biological sciences and medical sciences
Mau T,O'Brien M,Ghosh AK,Miller RA,Yung R
47-0114 was used in Flow cytometry/Cell sorting to study the effects of three drugs identified in the Interventions Testing Program on inflammation in gonadal white adipose tissue of HET3 mice.
Wed Jan 01 00:00:00 EST 2020
Adipose tissue dendritic cell signals are required to maintain T cell homeostasis and obesity-induced expansion.
Molecular and cellular endocrinology
Porsche CE,Delproposto JB,Patrick E,Zamarron BF,Lumeng CN
47-0114 was used in Flow cytometry/Cell sorting to investigate the contribution of dendritic cells to adipose tissue derived chronic inflammation as professional antigen presenting cells in adipose issue.
Sun Apr 05 00:00:00 EDT 2020
Pyruvate kinase M2 in lung APCs regulates Alternaria-induced airway inflammation.
Immunobiology
Jaiswal AK,Makhija S,Stahr N,Sandey M,Suryawanshi A,Mishra A
47-0114-82 was used in Flow Cytometry to support a model in which Alternaria sensitization in airways induce a circuitry of glycolysis and PKM2 regulation that confers an acute activation of APCs in the lung, whose targeting might represent a strategy for asthma treatment.
Wed Jul 01 00:00:00 EDT 2020
Environmental arginine controls multinuclear giant cell metabolism and formation.
Nature communications
Brunner JS,Vulliard L,Hofmann M,Kieler M,Lercher A,Vogel A,Russier M,Brüggenthies JB,Kerndl M,Saferding V,Niederreiter B,Junza A,Frauenstein A,Scholtysek C,Mikami Y,Klavins K,Krönke G,Bergthaler A,O'Shea JJ,Weichhart T,Meissner F,Smolen JS,Cheng P,Yanes O,Menche J,Murray PJ,Sharif O,Blüml S,Schabbauer G
47-0114 was used in Flow cytometry/Cell sorting to establish how environmental amino acids control the metabolic fate of polykaryons and suggest metabolic ways to manipulate multinucleated giant cell (MGC)-associated pathologies and bone remodelling.
Wed Jan 22 00:00:00 EST 2020
CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.
Nature communications
Kuhn NF,Lopez AV,Li X,Cai W,Daniyan AF,Brentjens RJ
47-0114 was used in Flow cytometry/Cell sorting to demonstrate the stimulatory effect of CD40L-overexpressing CAR T cells on innate and adaptive immune cells, and provide a rationale for using CD40L-overexpressing CAR T cells to improve immunotherapy responses.
Wed Dec 02 00:00:00 EST 2020
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Nature communications
Watanabe M,Lu Y,Breen M,Hodes RJ
47-0114 was used in Flow cytometry/Cell sorting to reveal a function of B7-CD28 co-stimulation in shaping the T cell repertoire and limiting autoimmunity through both thymic clonal deletion and Treg cell generation.
Tue Dec 08 00:00:00 EST 2020
Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.
Communications biology
Waaler J,Mygland L,Tveita A,Strand MF,Solberg NT,Olsen PA,Aizenshtadt A,Fauskanger M,Lund K,Brinch SA,Lycke M,Dybing E,Nygaard V,Bøe SL,Heintz KM,Hovig E,Hammarström C,Corthay A,Krauss S
47-0114 was used in Flow cytometry/Cell sorting to show that a specific small-molecule tankyrase inhibitor, G007-LK, decreases WNT/β-catenin and YAP signaling in the syngeneic murine B16-F10 and Clone M-3 melanoma models and sensitizes the tumors to anti-PD-1 immune checkpoint therapy.
Fri Apr 24 00:00:00 EDT 2020
Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity.
Cell reports
Zhivaki D,Borriello F,Chow OA,Doran B,Fleming I,Theisen DJ,Pallis P,Shalek AK,Sokol CL,Zanoni I,Kagan JC
47-0114 was used in Flow cytometry/Cell sorting to study how hyperactivating stimuli can induce CTL-mediated anti-tumor immunity against tumors that are both sensitive and resistant to PD-1 inhibitior.
Tue Nov 17 00:00:00 EST 2020
Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING.
eLife
Piersma SJ,Poursine-Laurent J,Yang L,Barber GN,Parikh BA,Yokoyama WM
47-0114 was used in Flow cytometry/Cell sorting to contrast anti-viral effects of MyD88 versus STING in distinct cell types that are infected with murine CMV (MCMV).
Wed Jul 29 00:00:00 EDT 2020
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.
Nature
Escolano A,Gristick HB,Abernathy ME,Merkenschlager J,Gautam R,Oliveira TY,Pai J,West AP,Barnes CO,Cohen AA,Wang H,Golijanin J,Yost D,Keeffe JR,Wang Z,Zhao P,Yao KH,Bauer J,Nogueira L,Gao H,Voll AV,Montefiori DC,Seaman MS,Gazumyan A,Silva M,McGuire AT,Stamatatos L,Irvine DJ,Wells L,Martin MA,Bjorkman PJ,Nussenzweig MC
47-0114-82 was used in Flow Cytometry to develop an immunogen, RC1, that facilitates the recognition of the variable loop 3 (V3)-glycan patch on the envelope protein of HIV-1 to activate B cells that express precursors of broadly neutralizing antibodies within polyclonal repertoires.
Sat Jun 01 00:00:00 EDT 2019
Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis.
Cell metabolism
Camell CD,Günther P,Lee A,Goldberg EL,Spadaro O,Youm YH,Bartke A,Hubbard GB,Ikeno Y,Ruddle NH,Schultze J,Dixit VD
47-0114 was used in Flow cytometry/Cell sorting to study the role of ageing within alterations of adipose tissue.
Tue Dec 03 00:00:00 EST 2019
Toxin-Triggered Interleukin-1 Receptor Signaling Enables Early-Life Discrimination of Pathogenic versus Commensal Skin Bacteria.
Cell host & microbe
Leech JM,Dhariwala MO,Lowe MM,Chu K,Merana GR,Cornuot C,Weckel A,Ma JM,Leitner EG,Gonzalez JR,Vasquez KS,Diep BA,Scharschmidt TC
47-0114-82 was used in Flow cytometry/Cell sorting to study how skin colonization by commensal Staphylococcus epidermidis facilitates immune tolerance preferentially in neonates via induction of antigen-specific regulatory T cells.
Wed Dec 11 00:00:00 EST 2019
Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins.
The Journal of cell biology
Jürgensen HJ,Nørregaard KS,Sibree MM,Santoni-Rugiu E,Madsen DH,Wassilew K,Krustrup D,Garred P,Bugge TH,Engelholm LH,Behrendt N
47-0114 was used in Flow cytometry/Cell sorting to show that fibroblasts in injured tissues undertake the clearance of collectins by using the endocytic collagen receptor uPARAP.
Mon Jan 07 00:00:00 EST 2019
TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.
Journal of immunology (Baltimore, Md. : 1950)
Kotov DI,Mitchell JS,Pengo T,Ruedl C,Way SS,Langlois RA,Fife BT,Jenkins MK
47-0114-82 was used in Flow Cytometry to study TCR affinity and influence on regulation of genes in naive T cells that control the differentiation process in cells.
Wed May 01 00:00:00 EDT 2019
Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population.
Cell reports
Leylek R,Alcántara-Hernández M,Lanzar Z,Lüdtke A,Perez OA,Reizis B,Idoyaga J
47-0114 was used in Flow cytometry/Cell sorting to provide a framework for deciphering the function of pDCs and tDCs during diseases, which has the potential to open new avenues for therapeutic design.
Tue Dec 10 00:00:00 EST 2019
Reprogramming the adjuvant properties of aluminum oxyhydroxide with nanoparticle technology.
NPJ vaccines
Orr MT,Khandhar AP,Seydoux E,Liang H,Gage E,Mikasa T,Beebe EL,Rintala ND,Persson KH,Ahniyaz A,Carter D,Reed SG,Fox CB
Thu Oct 01 00:00:00 EDT 2020
Peptide:MHCII Tetramer-Based Cell Enrichment for the Study of Epitope-Specific CD4+ T Cells.
Current protocols in immunology
Kotov DI,Jenkins MK
47-0114 was used in Flow cytometry/Cell sorting to study polyclonal epitope-specific CD4+ T cells under physiological conditions.
Sat Jun 01 00:00:00 EDT 2019
Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production.
Frontiers in immunology
Kiss MG,Ozsvár-Kozma M,Porsch F,Göderle L,Papac-Miličević N,Bartolini-Gritti B,Tsiantoulas D,Pickering MC,Binder CJ
47-0114-82 was used in Flow Cytometry to indicate that CFH, through its function as a complement repressor, acts as a negative regulator of BCR signaling and limits autoimmunity.
Tue Oct 13 00:00:00 EDT 2020
Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation.
Immunity
Emgård J,Kammoun H,García-Cassani B,Chesné J,Parigi SM,Jacob JM,Cheng HW,Evren E,Das S,Czarnewski P,Sleiers N,Melo-Gonzalez F,Kvedaraite E,Svensson M,Scandella E,Hepworth MR,Huber S,Ludewig B,Peduto L,Villablanca EJ,Veiga-Fernandes H,Pereira JP,Flavell RA,Willinger T
47-0114-82 was used in Flow Cytometry to show that GPR183 promotes lymphoid organ development and indicate that oxysterol-GPR183-dependent positioning within tissues controls ILC3 activity and intestinal homeostasis.
Tue Jan 16 00:00:00 EST 2018
A Macrophage Colony-Stimulating-Factor-Producing γδ T Cell Subset Prevents Malarial Parasitemic Recurrence.
Immunity
Mamedov MR,Scholzen A,Nair RV,Cumnock K,Kenkel JA,Oliveira JHM,Trujillo DL,Saligrama N,Zhang Y,Rubelt F,Schneider DS,Chien YH,Sauerwein RW,Davis MM
47-0114-82 was used in Flow Cytometry to point to an M-CSF-producing γδ T cell subset that fulfills a specialized protective role in the later stage of malaria infection when αβ T cells have declined.
Tue Feb 20 00:00:00 EST 2018
The WD40 domain of ATG16L1 is required for its non-canonical role in lipidation of LC3 at single membranes.
The EMBO journal
Fletcher K,Ulferts R,Jacquin E,Veith T,Gammoh N,Arasteh JM,Mayer U,Carding SR,Wileman T,Beale R,Florey O
47-0114 was used in Flow cytometry/Cell sorting to demonstrate activation of non-canonical autophagy dependent on the WD40 CTD during influenza A virus infection.
Thu Feb 15 00:00:00 EST 2018
De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.
Frontiers in immunology
Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L
47-0114-82 was used in Flow Cytometry to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.
Wed Apr 10 00:00:00 EDT 2019
Macrophages orchestrate breast cancer early dissemination and metastasis.
Nature communications
Linde N,Casanova-Acebes M,Sosa MS,Mortha A,Rahman A,Farias E,Harper K,Tardio E,Reyes Torres I,Jones J,Condeelis J,Merad M,Aguirre-Ghiso JA
47-0114 was used in Flow cytometry/Cell sorting to show that, in pre-malignant lesions, CCL2 produced by cancer cells and myeloid cells attracts CD206+/Tie2+macrophages and induces Wnt-1 upregulation that in turn downregulates E-cadherin junctions in the HER2+early cancer cells.
Tue Jan 02 00:00:00 EST 2018
T-Bet+ IgM Memory Cells Generate Multi-lineage Effector B Cells.
Cell reports
Kenderes KJ,Levack RC,Papillion AM,Cabrera-Martinez B,Dishaw LM,Winslow GM
47-0114 was used in Flow cytometry/Cell sorting to propose that T-bet+ IgM memory cells can differentiate into any effector B cell lineage to provide long-term multifunctional immunity.
Tue Jul 24 00:00:00 EDT 2018
CCR7 defines a precursor for murine iNKT cells in thymus and periphery.
eLife
Wang H,Hogquist KA
47-0114 was used in Flow cytometry/Cell sorting to demonstrate that the thymus is both a source of iNKT progenitors and a site of tissue dependent effector cell differentiation.
Mon Aug 13 00:00:00 EDT 2018
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing.
Nature
Camell CD,Sander J,Spadaro O,Lee A,Nguyen KY,Wing A,Goldberg EL,Youm YH,Brown CW,Elsworth J,Rodeheffer MS,Schultze JL,Dixit VD
47-0114 was used in Flow cytometry/Cell sorting to show that adipose tissue macrophages regulate the age-related reduction in adipocyte lipolysis in mice by lowering the bioavailability of noradrenaline.
Thu Oct 05 00:00:00 EDT 2017
Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.
Cell host & microbe
Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y
47-0114 was used in Flow cytometry/Cell sorting to demonstrate that autoreactive T-cells and chronic fungal infection, fostered by inflammation and epithelial injury, promote esophageal squamous cell carcinoma development.
Wed Apr 12 00:00:00 EDT 2017
DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.
The Journal of experimental medicine
Lehmann CHK,Baranska A,Heidkamp GF,Heger L,Neubert K,Lühr JJ,Hoffmann A,Reimer KC,Brückner C,Beck S,Seeling M,Kießling M,Soulat D,Krug AB,Ravetch JV,Leusen JHW,Nimmerjahn F,Dudziak D
47-0114 was used in Flow cytometry/Cell sorting to suggest that targeting antigens to FcγRs on DCs may be a promising approach to raise immunogenic or tolerogenic T cell responses to antigens of choice.
Mon May 01 00:00:00 EDT 2017
Resident macrophages of pancreatic islets have a seminal role in the initiation of autoimmune diabetes of NOD mice.
Proceedings of the National Academy of Sciences of the United States of America
Carrero JA,McCarthy DP,Ferris ST,Wan X,Hu H,Zinselmeyer BH,Vomund AN,Unanue ER
47-0114 was used in Flow cytometry/Cell sorting to study the role of resident macrophages of the pancreatic islets in the initiation of autoimmune diabetes of NOD mice.
Tue Nov 28 00:00:00 EST 2017
MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.
PLoS pathogens
Friedrich C,Mamareli P,Thiemann S,Kruse F,Wang Z,Holzmann B,Strowig T,Sparwasser T,Lochner M
Mon May 01 00:00:00 EDT 2017
Location of tumor affects local and distant immune cell type and number.
Immunity, inflammation and disease
Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S
47-0114 was used in Flow cytometry/Cell sorting to demonstrate that location of tumour, and not simply the tumour itself, has a definitive role in regulating immune effectors.
Wed Mar 01 00:00:00 EST 2017
Differential regulation of C5a receptor 1 in innate immune cells during the allergic asthma effector phase.
PloS one
Ender F,Wiese AV,Schmudde I,Sun J,Vollbrandt T,König P,Laumonnier Y,Köhl J
47-0114 was used in Flow cytometry/Cell sorting to demonstrate a complex regulation pattern of C5aR1 in the airways, lung tissue and lymph nodes of mice.
Thu Aug 17 00:00:00 EDT 2017
IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization.
The Journal of experimental medicine
Yoon J,Leyva-Castillo JM,Wang G,Galand C,Oyoshi MK,Kumar L,Hoff S,He R,Chervonsky A,Oppenheim JJ,Kuchroo VK,van den Brink MR,Malefyt Rde W,Tessier PA,Fuhlbrigge R,Rosenstiel P,Terhorst C,Murphy G,Geha RS
47-0114 was used in Flow cytometry/Cell sorting to elucidate the mechanisms behind DC-derived IL-23 in a model of skin inflammation.
Mon Sep 19 00:00:00 EDT 2016
Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation.
Molecular metabolism
Johnson AR,Qin Y,Cozzo AJ,Freemerman AJ,Huang MJ,Zhao L,Sampey BP,Milner JJ,Beck MA,Damania B,Rashid N,Galanko JA,Lee DP,Edin ML,Zeldin DC,Fueger PT,Dietz B,Stahl A,Wu Y,Mohlke KL,Makowski L
47-0114 was used in Flow cytometry/Cell sorting to outline a novel mechanism for regulating adipose tissue homoeostasis and inflammation through metabolic reprogramming of macrophages; directed by fatty acid transport protein 1.
Fri Jul 01 00:00:00 EDT 2016
IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing.
The Journal of investigative dermatology
Rak GD,Osborne LC,Siracusa MC,Kim BS,Wang K,Bayat A,Artis D,Volk SW
47-0114 was used in Flow cytometry/Cell sorting to demonstrate that cutaneous injury promotes an IL-33-dependent group 2 ILC response and that abrogation of this response can impair efficient wound closure.
Mon Feb 01 00:00:00 EST 2016
Mutations in G protein β subunits promote transformation and kinase inhibitor resistance.
Nature medicine
Yoda A,Adelmant G,Tamburini J,Chapuy B,Shindoh N,Yoda Y,Weigert O,Kopp N,Wu SC,Kim SS,Liu H,Tivey T,Christie AL,Elpek KG,Card J,Gritsman K,Gotlib J,Deininger MW,Makishima H,Turley SJ,Javidi-Sharifi N,Maciejewski JP,Jaiswal S,Ebert BL,Rodig SJ,Tyner JW,Marto JA,Weinstock DM,Lane AA
47011482 was used in flow cytometry to investigate the role of GNB1 and GNB2 in cancer cells.
Thu Jan 01 00:00:00 EST 2015
Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.
Nature immunology
Grajales-Reyes GE,Iwata A,Albring J,Wu X,Tussiwand R,Kc W,Kretzer NM,Briseño CG,Durai V,Bagadia P,Haldar M,Schönheit J,Rosenbauer F,Murphy TL,Murphy KM
47-0114 was used in Flow cytometry/Cell sorting to investigate the role of the transcription factors Batf3 and IRF8 in the development of CD8α(+) conventional dendritic cells (cDCs)..
Wed Jul 01 00:00:00 EDT 2015
Kinetic profiling of in vivo lung cellular inflammatory responses to mechanical ventilation.
American journal of physiology. Lung cellular and molecular physiology
Woods SJ,Waite AA,O'Dea KP,Halford P,Takata M,Wilson MR
47-0114 was used in Flow cytometry/Cell sorting to identify the profile of in vivo lung cellular activation that occurs during the initiation of VILI.
Fri May 01 00:00:00 EDT 2015
Natural Killer Cells Mediate Protection against Yersinia pseudotuberculosis in the Mesenteric Lymph Nodes.
PloS one
Rosenheinrich M,Heine W,Schmühl CM,Pisano F,Dersch P
47-0114 was used in Flow cytometry/Cell sorting to characterise the role of natural killer cells in the response to the extracellular bacterial pathogen, yersiniae.
Tue May 10 00:00:00 EDT 2016
Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes.
Nature medicine
Clatworthy MR,Aronin CE,Mathews RJ,Morgan NY,Smith KG,Germain RN
47-0114 was used in Flow cytometry/Cell sorting to study how immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes.
Mon Dec 01 00:00:00 EST 2014
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
Nature immunology
Agudo J,Ruzo A,Tung N,Salmon H,Leboeuf M,Hashimoto D,Becker C,Garrett-Sinha LA,Baccarini A,Merad M,Brown BD
47-0114 was used in Flow cytometry/Cell sorting to identify the miR-126-VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs.
Wed Jan 01 00:00:00 EST 2014
Intravascular staining for discrimination of vascular and tissue leukocytes.
Nature protocols
Anderson KG,Mayer-Barber K,Sung H,Beura L,James BR,Taylor JJ,Qunaj L,Griffith TS,Vezys V,Barber DL,Masopust D
47-0114 was used in Flow cytometry/Cell sorting to outline a protocol for the validation and use of intravascular staining to define innate and adaptive immune cells in mice.
Wed Jan 01 00:00:00 EST 2014
Antigen delivery to CD11c+CD8- dendritic cells induces protective immune responses against experimental melanoma in mice in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Neubert K,Lehmann CH,Heger L,Baranska A,Staedtler AM,Buchholz VR,Yamazaki S,Heidkamp GF,Eissing N,Zebroski H,Nussenzweig MC,Nimmerjahn F,Dudziak D
47-0114 was used in Flow cytometry/Cell sorting to assess the anti-tumour efficacy of a highly selective immunisation-based therapy.
Sun Jun 15 00:00:00 EDT 2014
Influence of PhoP and intra-species variations on virulence of Yersinia pseudotuberculosis during the natural oral infection route.
PloS one
Pisano F,Heine W,Rosenheinrich M,Schweer J,Nuss AM,Dersch P
47-0114 was used in Flow cytometry/Cell sorting to investigate the role of PhoP in oral infections, showing that virulence of Yersinia pseudotuberculosis is influenced by PhoP and intra-species variations.
Thu Nov 12 00:00:00 EST 2015
IL-3 and CSF-1 interact to promote generation of CD11c+ IL-10-producing macrophages.
PloS one
Sheng KC,Herrero LJ,Taylor A,Hapel AJ,Mahalingam S
47-0114 was used in Flow cytometry/Cell sorting to investigate the mechanisms of regulation of hematopoiesis.
Tue Dec 30 00:00:00 EST 2014
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
Nature immunology
Satpathy AT,Briseño CG,Lee JS,Ng D,Manieri NA,Kc W,Wu X,Thomas SR,Lee WL,Turkoz M,McDonald KG,Meredith MM,Song C,Guidos CJ,Newberry RD,Ouyang W,Murphy TL,Stappenbeck TS,Gommerman JL,Nussenzweig MC,Colonna M,Kopan R,Murphy KM
47-0114 was used in Flow cytometry/Cell sorting to elucidate the cellular source of essential IL-23 production required for the mucosal response to attaching-and-effacing bacterial infection.
Sun Sep 01 00:00:00 EDT 2013
Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells.
Proceedings of the National Academy of Sciences of the United States of America
McKee AS,Burchill MA,Munks MW,Jin L,Kappler JW,Friedman RS,Jacobelli J,Marrack P
47-0114 was used in Flow cytometry/Cell sorting to study how aluminium acts as an adjuvant by introducing host DNA into the cytoplasm of dendritic cells, where it engages receptors promoting MHC II presentation.
Tue Mar 19 00:00:00 EDT 2013
Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.
The Journal of experimental medicine
Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM
47-0114 was used in Immunofluorescence to identify Zbtb46 as a transcription factor selectively expressed by classical DCs and their committed progenitors.
Mon Jun 04 00:00:00 EDT 2012
Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.
The Journal of experimental medicine
Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM
47-0114 was used in Immunofluorescence to identify Zbtb46 as a transcription factor selectively expressed by classical DCs and their committed progenitors.
Mon Jun 04 00:00:00 EDT 2012
A TLR and non-TLR mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockade.
Molecular therapy : the journal of the American Society of Gene Therapy
Agudo J,Ruzo A,Kitur K,Sachidanandam R,Blander JM,Brown BD
47-0114 was used in Flow cytometry/Cell sorting to characterise the transient innate immune reaction to lentiviral vector, and evaluate a means for its prevention during LV-mediated gene transfer.
Sat Dec 01 00:00:00 EST 2012
CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes.
Immunity
Edelson BT,Bradstreet TR,Hildner K,Carrero JA,Frederick KE,KC W,Belizaire R,Aoshi T,Schreiber RD,Miller MJ,Murphy TL,Unanue ER,Murphy KM
47-0114 was used in Flow cytometry/Cell sorting to elucidate the mechanism by which Listeria establishes productive infection in mice.
Fri Aug 26 00:00:00 EDT 2011
Functional redundancy between thymic CD8α+ and Sirpα+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins.
Journal of immunology (Baltimore, Md. : 1950)
Atibalentja DF,Murphy KM,Unanue ER
47-0114 was used in Flow cytometry/Cell sorting to evaluate the presentation of blood-derived protein Ags by antigen presenting cells in the thymus.
Tue Feb 01 00:00:00 EST 2011
Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloCD103- dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Smith KA,Hochweller K,Hämmerling GJ,Boon L,MacDonald AS,Maizels RM
47-0114 was used in Flow cytometry/Cell sorting to identify that the preferential expansion of a novel population of CD11c(lo) non-plasmacytoid DCs is associated with the pro-regulatory environment of chronic intestinal helminth infection.
Wed Jun 15 00:00:00 EDT 2011
Genetic variation determines mast cell functions in experimental asthma.
Journal of immunology (Baltimore, Md. : 1950)
Becker M,Reuter S,Friedrich P,Doener F,Michel A,Bopp T,Klein M,Schmitt E,Schild H,Radsak MP,Echtenacher B,Taube C,Stassen M
47-0114 was used in Flow cytometry/Cell sorting to investigate the role of mast cells in allergic asthma.
Wed Jun 15 00:00:00 EDT 2011
Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization.
PloS one
Edelson BT,Bradstreet TR,KC W,Hildner K,Herzog JW,Sim J,Russell JH,Murphy TL,Unanue ER,Murphy KM
47-0114 was used in Flow cytometry/Cell sorting to compare development of peripheral tissue dendritic cells, and susceptibility to experimental autoimmune encephalitis in GM-CSF receptor deficient mice.
Thu Mar 15 00:00:00 EDT 2012
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells.
The Journal of experimental medicine
Edelson BT,KC W,Juang R,Kohyama M,Benoit LA,Klekotka PA,Moon C,Albring JC,Ise W,Michael DG,Bhattacharya D,Stappenbeck TS,Holtzman MJ,Sung SS,Murphy TL,Hildner K,Murphy KM
47-0114 was used in Flow cytometry/Cell sorting to study the relationship between nonlymphoid CD103-expressing dendritic cells (DCs) and other DC subsets.
Mon Apr 12 00:00:00 EDT 2010