Product References
NLRP12-expressing dendritic cells mediate both dissemination of infection and adaptive immune responses in visceral leishmaniasis.
iScience
Valadares DG,Clay OS,Chen Y,Scorza BM,Cassel SL,Sutterwala FS,Wilson ME
45-5932-82 was used in Flow Cytometry to hypothesize that Nlrp12-expressing DCs are required for efficient dissemination and immune clearance of L. infantum from the site of initial infection.
Fri Mar 17 00:00:00 EDT 2023
Human T cells efficiently control RSV infection.
JCI insight
De C,Pickles RJ,Yao W,Liao B,Boone A,Choi M,Battaglia DM,Askin FB,Whitmire JK,Silvestri G,Garcia JV,Wahl A
45-5932-82 was used in Flow cytometry/Cell sorting to support the development of Respiratory syncytial virus (RSV) vaccines, which also elicit effective T cell responses to improve RSV vaccine efficacy.
Thu Jun 08 00:00:00 EDT 2023
Non-Oncogene Addiction of KRAS-Mutant Cancers to IL-1β via Versican and Mononuclear IKKβ.
Cancers
Spella M,Ntaliarda G,Skiadas G,Lamort AS,Vreka M,Marazioti A,Lilis I,Bouloukou E,Giotopoulou GA,Pepe MAA,Weiss SAI,Petrera A,Hauck SM,Koch I,Lindner M,Hatz RA,Behr J,Arendt KAM,Giopanou I,Brunn D,Savai R,Jenne DE,de Château M,Yull FE,Blackwell TS,Stathopoulos GT
45-5932-82 was used in Flow Cytometry to show that human KRAS-mutant cancers are addicted to IL-1β via inflammatory versican signaling to macrophage inhibitor of NF-κB kinase (IKK) β.
Mon Mar 20 00:00:00 EDT 2023
Trained immunity induction by the inactivated mucosal vaccine MV130 protects against experimental viral respiratory infections.
Cell reports
Brandi P,Conejero L,Cueto FJ,Martínez-Cano S,Dunphy G,Gómez MJ,Relaño C,Saz-Leal P,Enamorado M,Quintas A,Dopazo A,Amores-Iniesta J,Del Fresno C,Nistal-Villán E,Ardavín C,Nieto A,Casanovas M,Subiza JL,Sancho D
45-5932-82 was used in Flow cytometry/Cell sorting to show that intranasal prophylaxis with MV130 modulates the lung immune landscape and provides long-term heterologous protection against viral respiratory infections in mice.
Tue Jan 04 00:00:00 EST 2022
TLR7 controls myeloid-derived suppressor cells expansion and function in the lung of C57BL6 mice infected with Schistosoma japonicum.
PLoS neglected tropical diseases
Zhou L,Zhu Y,Mo L,Wang M,Lin J,Zhao Y,Feng Y,Xie A,Wei H,Qiu H,Huang J,Yang Q
45-5932-82 was used in Immunohistochemistry (Paraffin) to indicate that TLR7 signaling inhibits the accumulation and function of MDSCs in S. japonicum infected mouse lung by down-regulating the expression of PD-L1/2 and secreting of IL-10, via NF-κB signaling.
Sat Oct 01 00:00:00 EDT 2022
Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity.
Cancer cell
Chryplewicz A,Scotton J,Tichet M,Zomer A,Shchors K,Joyce JA,Homicsko K,Hanahan D
45-5932-82 was used in flow cytometry to assess this concept by combining vascular endothelial growth factor (VEGF) pathway inhibitors that remodel the tumor vasculature with the tricyclic antidepressant imipramine, which enhances autophagy in GBM cancer cells and unexpectedly reprograms immunosuppressive tumor-associated macrophages via inhibition of histamine receptor signaling to become immunostimulatory.
Mon Oct 10 00:00:00 EDT 2022
The cephalic phase of insulin release is modulated by IL-1β.
Cell metabolism
Wiedemann SJ,Trimigliozzi K,Dror E,Meier DT,Molina-Tijeras JA,Rachid L,Le Foll C,Magnan C,Schulze F,Stawiski M,Häuselmann SP,Méreau H,Böni-Schnetzler M,Donath MY
45-5932-82 was used in Flow cytometry/Cell sorting to describe that this incretin-like effect of IL-1β involves neuronal transmission.
Tue Jul 05 00:00:00 EDT 2022
ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression.
Cell death & disease
Grube J,Woitok MM,Mohs A,Erschfeld S,Lynen C,Trautwein C,Otto T
45-5932-82 was used in Flow cytometry/Cell sorting to investigate the role of ferroptosis, a type of programmed cell death involving iron-dependent peroxidation of membrane phospholipids, in liver cancer (hepatocellular carcinoma) using mouse models of chronic injury-dependent HCC formation.
Sat Aug 13 00:00:00 EDT 2022
P140 Peptide Leads to Clearance of Autoreactive Lymphocytes and Normalizes Immune Response in Lupus-Prone Mice.
Frontiers in immunology
Schall N,Talamini L,Wilhelm M,Jouvin-Marche E,Muller S
45-5932-82 was used in Flow cytometry/Cell sorting to suggest that P140 belongs to a new family of non-immunosuppressive immunoregulators that do not correct T and B cell abnormalities but rather contribute to the clearance of deleterious T and B cells.
Tue Jun 21 00:00:00 EDT 2022
Transcriptional and Distributional Profiling of Microglia in Retinal Angiomatous Proliferation.
International journal of molecular sciences
Schlecht A,Wolf J,Boneva S,Prinz G,Braunger BM,Wieghofer P,Agostini H,Schlunck G,Lange C
45-5932-82 was used in Flow cytometry/Cell sorting to find that MG are the dominant myeloid cell population at RAP sites, significantly altering their transcriptional profile during RAP formation, however, without showing substantial upregulation of angiomodulatory factors.
Tue Mar 22 00:00:00 EDT 2022
Kupffer Cells and Blood Monocytes Orchestrate the Clearance of Iron-Carbohydrate Nanoparticles from Serum.
International journal of molecular sciences
Arsiwala T,Vogt AS,Barton AE,Manolova V,Funk F,Flühmann B,Bachmann MF
45-5932-82 was used in Flow cytometry/Cell sorting to investigate the mechanism of mononuclear phagocyte system-mediated clearance of IV iron nanoparticles.
Mon Feb 28 00:00:00 EST 2022
Helminth resistance is mediated by differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion.
Cell reports
Chen F,El-Naccache DW,Ponessa JJ,Lemenze A,Espinosa V,Wu W,Lothstein K,Jin L,Antao O,Weinstein JS,Damani-Yokota P,Khanna K,Murray PJ,Rivera A,Siracusa MC,Gause WC
45-5932-82 was used in Flow Cytometry to indicate that recruited monocytes are selectively programmed in the pulmonary environment to express AM markers and an anti-helminth phenotype.
Tue Jan 11 00:00:00 EST 2022
The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis.
Nature communications
Chen H,Chew G,Devapragash N,Loh JZ,Huang KY,Guo J,Liu S,Tan ELS,Chen S,Tee NGZ,Mia MM,Singh MK,Zhang A,Behmoaras J,Petretto E
45-5932-82 was used in Flow cytometry/Cell sorting to identify a pro-fibrogenic macrophage subtype in non-ischemic cardiomyopathy, and demonstrate that WWP2 is a key regulator of IRF7-mediated Ccl5/Ly6chigh monocyte axis in heart fibrosis.
Wed Nov 30 00:00:00 EST 2022
Nonredundancy of IL-1α and IL-1β is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection.
Science advances
Eislmayr K,Bestehorn A,Morelli L,Borroni M,Vande Walle L,Lamkanfi M,Kovarik P
45-5932-82 was used in Flow Cytometry to investigate why interleukin-1α and -1β are not redundant in vivo despite triggering the same receptor and eliciting comparable cellular responses.
Fri Mar 04 00:00:00 EST 2022
IL-1 Receptor-1 on Vglut2 + neurons in the hippocampus is critical for neuronal and behavioral sensitization after repeated social stress.
Brain, behavior, & immunity - health
DiSabato DJ,Yin W,Biltz RG,Gallagher NR,Oliver B,Nemeth DP,Liu X,Sheridan JF,Quan N,Godbout JP
45-5932-82 was used in Flow cytometry/Cell sorting to show that IL-1 signaling in glutamatergic neurons of the hippocampus was essential in neuronal-sensitization after social defeat and the recall of social withdrawal.
Thu Dec 01 00:00:00 EST 2022
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition).
European journal of immunology
Cossarizza A,Chang HD,Radbruch A,Abrignani S,Addo R,Akdis M,Andrä I,Andreata F,Annunziato F,Arranz E,Bacher P,Bari S,Barnaba V,Barros-Martins J,Baumjohann D,Beccaria CG,Bernardo D,Boardman DA,Borger J,Böttcher C,Brockmann L,Burns M,Busch DH,Cameron G,Cammarata I,Cassotta A,Chang Y,Chirdo FG,Christakou E,Čičin-Šain L,Cook L,Corbett AJ,Cornelis R,Cosmi L,Davey MS,De Biasi S,De Simone G,Del Zotto G,Delacher M,Di Rosa F,Di Santo J,Diefenbach A,Dong J,Dörner T,Dress RJ,Dutertre CA,Eckle SBG,Eede P,Evrard M,Falk CS,Feuerer M,Fillatreau S,Fiz-Lopez A,Follo M,Foulds GA,Fröbel J,Gagliani N,Galletti G,Gangaev A,Garbi N,Garrote JA,Geginat J,Gherardin NA,Gibellini L,Ginhoux F,Godfrey DI,Gruarin P,Haftmann C,Hansmann L,Harpur CM,Hayday AC,Heine G,Hernández DC,Herrmann M,Hoelsken O,Huang Q,Huber S,Huber JE,Huehn J,Hundemer M,Hwang WYK,Iannacone M,Ivison SM,Jäck HM,Jani PK,Keller B,Kessler N,Ketelaars S,Knop L,Knopf J,Koay HF,Kobow K,Kriegsmann K,Kristyanto H,Krueger A,Kuehne JF,Kunze-Schumacher H,Kvistborg P,Kwok I,Latorre D,Lenz D,Levings MK,Lino AC,Liotta F,Long HM,Lugli E,MacDonald KN,Maggi L,Maini MK,Mair F,Manta C,Manz RA,Mashreghi MF,Mazzoni A,McCluskey J,Mei HE,Melchers F,Melzer S,Mielenz D,Monin L,Moretta L,Multhoff G,Muñoz LE,Muñoz-Ruiz M,Muscate F,Natalini A,Neumann K,Ng LG,Niedobitek A,Niemz J,Almeida LN,Notarbartolo S,Ostendorf L,Pallett LJ,Patel AA,Percin GI,Peruzzi G,Pinti M,Pockley AG,Pracht K,Prinz I,Pujol-Autonell I,Pulvirenti N,Quatrini L,Quinn KM,Radbruch H,Rhys H,Rodrigo MB,Romagnani C,Saggau C,Sakaguchi S,Sallusto F,Sanderink L,Sandrock I,Schauer C,Scheffold A,Scherer HU,Schiemann M,Schildberg FA,Schober K,Schoen J,Schuh W,Schüler T,Schulz AR,Schulz S,Schulze J,Simonetti S,Singh J,Sitnik KM,Stark R,Starossom S,Stehle C,Szelinski F,Tan L,Tarnok A,Tornack J,Tree TIM,van Beek JJP,van de Veen W,van Gisbergen K,Vasco C,Verheyden NA,von Borstel A,Ward-Hartstonge KA,Warnatz K,Waskow C,Wiedemann A,Wilharm A,Wing J,Wirz O,Wittner J,Yang JHM,Yang J
45-5932-82 was used in Flow cytometry/Cell sorting to provide the key aspects to consider when performing flow cytometry experiments.
Wed Dec 01 00:00:00 EST 2021
Cross-tissue organization of the fibroblast lineage.
Nature
Buechler MB,Pradhan RN,Krishnamurty AT,Cox C,Calviello AK,Wang AW,Yang YA,Tam L,Caothien R,Roose-Girma M,Modrusan Z,Arron JR,Bourgon R,Müller S,Turley SJ
45-5932-82 was used in Flow cytometry/Cell sorting to conclude that a cross-species and pan-tissue approach to transcriptomics at single-cell resolution has identified key organizing principles of the fibroblast lineage in health and disease.
Sat May 01 00:00:00 EDT 2021
Temporospatial distribution and transcriptional profile of retinal microglia in the oxygen-induced retinopathy mouse model.
Glia
Boeck M,Thien A,Wolf J,Hagemeyer N,Laich Y,Yusuf D,Backofen R,Zhang P,Boneva S,Stahl A,Hilgendorf I,Agostini H,Prinz M,Wieghofer P,Schlunck G,Schlecht A,Lange C
45-5932 was used in Flow cytometry/Cell sorting to determine the extent of MG proliferation and M infiltration in areas with retinal ischemia and RNV in Cx3cr1CreERT2 :Rosa26-tdTomato mice and examine the transcriptional profile of MG in the mouse model of oxygen-induced retinopathy (OIR).
Tue Sep 01 00:00:00 EDT 2020
NLRX1 is a key regulator of immune signaling during invasive pulmonary aspergillosis.
PLoS pathogens
Kastelberg B,Tubau-Juni N,Ayubi T,Leung A,Leber A,Hontecillas R,Bassaganya-Riera J,Kale SD
45-5932 was used in Flow cytometry/Cell sorting to point strongly towards the cell-specific and contextual function of Nlrx1 during invasive pulmonary aspergillosis and may lead to novel therapeutics to reduce Th2 responses by CD103+ DCs or heightened recruitment of neutrophils.
Tue Sep 01 00:00:00 EDT 2020
Secreted Phosphoprotein 1 Expression in Retinal Mononuclear Phagocytes Links Murine to Human Choroidal Neovascularization.
Frontiers in cell and developmental biology
Schlecht A,Zhang P,Wolf J,Thien A,Rosmus DD,Boneva S,Schlunck G,Lange C,Wieghofer P
45-5932-82 was used in Flow Cytometry to highlight the importance of SPP1 in the formation of CNV and potentially offer new opportunities for therapeutic intervention by modulating the SPP1 pathway.
Tue Feb 16 00:00:00 EST 2021
Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke.
Experimental neurology
Srivastava P,Cronin CG,Scranton VL,Jacobson KA,Liang BT,Verma R
45-5932-82 was used in Flow Cytometry to suggest that acute P2X4R inhibition protects against ischemic injury both at acute and chronic time-points after stroke.
Wed Jul 01 00:00:00 EDT 2020
TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice.
Cell reports
Liu CY,Tam SS,Huang Y,Dubé PE,Alhosh R,Girish N,Punit S,Nataneli S,Li F,Bender JM,Washington MK,Polk DB
45-5932-82 was used in Flow Cytometry to demonstrate the net anti-inflammatory functions of TNF/TNFR1 signaling through the regulation of colonic immune homeostasis in early life.
Tue Oct 20 00:00:00 EDT 2020
Distinct Transcriptional Responses across Tissue-Resident Macrophages to Short-Term and Long-Term Metabolic Challenge.
Cell reports
Brykczynska U,Geigges M,Wiedemann SJ,Dror E,Böni-Schnetzler M,Hess C,Donath MY,Paro R
45-5932 was used in Flow cytometry/Cell sorting to provide a resource for assessing the impact of nutrition and over-nutrition on the spectrum of macrophages across tissues with a potential for identification of systemic responses.
Tue Feb 04 00:00:00 EST 2020
Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of Cx3cr1.
eLife
Madel MB,Ibáñez L,Ciucci T,Halper J,Rouleau M,Boutin A,Hue C,Duroux-Richard I,Apparailly F,Garchon HJ,Wakkach A,Blin-Wakkach C
45-5932-82 was used in Flow Cytometry to investigate the contribution of mouse Cx3cr1+ and Cx3cr1neg i-OCLs to bone loss.
Wed May 13 00:00:00 EDT 2020
Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.
International journal of molecular sciences
Yoon CH,Ryu JS,Hwang HS,Kim MK
45-5932 was used in Flow cytometry/Cell sorting to suggest that age-dependent DED in C57BL/6 mice is related to inflammation of the LGs, the development of MG atrophy, and oxidative stress in both glands.
Thu Jun 11 00:00:00 EDT 2020
PTPROt aggravates inflammation by enhancing NF-κB activation in liver macrophages during nonalcoholic steatohepatitis.
Theranostics
Jin K,Liu Y,Shi Y,Zhang H,Sun Y,Zhangyuan G,Wang F,Yu W,Wang J,Tao X,Chen X,Zhang W,Sun B
45-5932 was used in Flow cytometry/Cell sorting to indicate that PTPROt plays a dual role in inflammation via the NF-κB signaling pathway in liver macrophages during NASH.
Mon Jul 26 00:00:00 EDT 2021
Mesenchymal stromal cells induce distinct myeloid-derived suppressor cells in inflammation.
JCI insight
Lee HJ,Ko JH,Kim HJ,Jeong HJ,Oh JY
45-5932 was used in Flow cytometry/Cell sorting to reveal that suppression of prostaglandin E2 (PGE2) and HGF secretion in MSCs by siRNA transfection partially reversed the effects of MSCs on MDSC differentiation.
Thu Jun 18 00:00:00 EDT 2020
Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway.
eLife
Kim EH,Woodruff MC,Grigoryan L,Maier B,Lee SH,Mandal P,Cortese M,Natrajan MS,Ravindran R,Ma H,Merad M,Gitlin AD,Mocarski ES,Jacob J,Pulendran B
45-5932 was used in Flow cytometry/Cell sorting to demonstrate that squalene emulsion-based vaccine adjuvants induce antigen-specific CD8 T cell and antibody responses, through RIPK3-dependent and-independent pathways, respectively.
Tue Jun 09 00:00:00 EDT 2020
GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation.
Cell reports
Castro-Dopico T,Fleming A,Dennison TW,Ferdinand JR,Harcourt K,Stewart BJ,Cader Z,Tuong ZK,Jing C,Lok LSC,Mathews RJ,Portet A,Kaser A,Clare S,Clatworthy MR
45-5932 was used in Flow cytometry/Cell sorting to identify granulocyte-macrophage colony stimulating factor (GM-CSF) as a critical regulator of intestinal macrophage activation in patients with IBD and mice with dextran sodium sulfate (DSS)-induced colitis.
Tue Jul 07 00:00:00 EDT 2020
Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity.
Immunity
Martínez-López M,Iborra S,Conde-Garrosa R,Mastrangelo A,Danne C,Mann ER,Reid DM,Gaboriau-Routhiau V,Chaparro M,Lorenzo MP,Minnerup L,Saz-Leal P,Slack E,Kemp B,Gisbert JP,Dzionek A,Robinson MJ,Rupérez FJ,Cerf-Bensussan N,Brown GD,Bernardo D,LeibundGut-Landmann S,Sancho D
45-5932-82 was used in Flow Cytometry to conclude that sensing of commensals by Mincle and Syk signaling in CD11c+ cells reinforces intestinal immune barrier and promotes host-microbiota mutualism, preventing systemic inflammation.
Tue Feb 19 00:00:00 EST 2019
The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy.
Cellular & molecular immunology
Moschovakis GL,Bubke A,Friedrichsen M,Ristenpart J,Back JW,Falk CS,Kremmer E,Förster R
45-5932-82 was used in Flow Cytometry to demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA.
Tue Oct 01 00:00:00 EDT 2019
STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion.
Cell death and differentiation
Zhang CX,Ye SB,Ni JJ,Cai TT,Liu YN,Huang DJ,Mai HQ,Chen QY,He J,Zhang XS,Zeng YX,Li J,Cui J
45-5932-82 was used in Flow Cytometry to investigate the role of stimulator of interferon genes (STING) in regulation of myeloid-derived suppressor cell differentiation and antitumor immunity in Epstein-Barr virus-associated nasopharyngeal carcinomas.
Fri Nov 01 00:00:00 EDT 2019
Inflammation via myeloid differentiation primary response gene 88 signaling mediates the fibrotic response to implantable synthetic poly(ethylene glycol) hydrogels.
Acta biomaterialia
Amer LD,Saleh LS,Walker C,Thomas S,Janssen WJ,Alper S,Bryant SJ
45-5932 was used in Flow cytometry/Cell sorting to demonstrate that MyD88-mediated inflammation is responsible in part for the formation of the fibrous capsule of the FBR.
Sun Dec 01 00:00:00 EST 2019
Visualizing the Selectivity and Dynamics of Interferon Signaling In Vivo.
Cell reports
Stifter SA,Bhattacharyya N,Sawyer AJ,Cootes TA,Stambas J,Doyle SE,Feigenbaum L,Paul WE,Britton WJ,Sher A,Feng CG
45-5932-82 was used in Flow Cytometry to suggest that time- and cell-type-dependent integration of distinct IFN signals govern the specificity and magnitude of IFN responses in vivo.
Tue Dec 10 00:00:00 EST 2019
Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors.
Immunity
Sharma MD,Rodriguez PC,Koehn BH,Baban B,Cui Y,Guo G,Shimoda M,Pacholczyk R,Shi H,Lee EJ,Xu H,Johnson TS,He Y,Mergoub T,Venable C,Bronte V,Wolchok JD,Blazar BR,Munn DH
45-5932 was used in Flow cytometry/Cell sorting to show that during immunotherapy large numbers of cells expressing CD103 arose in murine tumours via direct differentiation of Ly6c+ monocytic precursors.
Tue Jan 16 00:00:00 EST 2018
Sympathetic Neuronal Activation Triggers Myeloid Progenitor Proliferation and Differentiation.
Immunity
Vasamsetti SB,Florentin J,Coppin E,Stiekema LCA,Zheng KH,Nisar MU,Sembrat J,Levinthal DJ,Rojas M,Stroes ESG,Kim K,Dutta P
45-5932 was used in Flow cytometry/Cell sorting to demonstrate that catecholamines produced by leukocytes and sympathetic nerve termini promote GMP proliferation and myeloid cell development.
Tue Jul 17 00:00:00 EDT 2018
Aging alters the immunological response to ischemic stroke.
Acta neuropathologica
Ritzel RM,Lai YJ,Crapser JD,Patel AR,Schrecengost A,Grenier JM,Mancini NS,Patrizz A,Jellison ER,Morales-Scheihing D,Venna VR,Kofler JK,Liu F,Verma R,McCullough LD
45-5932 was used in Flow cytometry/Cell sorting to study the marked differences in the composition of circulating and infiltrating leukocytes recruited to the ischaemic brain of old male mice after stroke compared to young male mice.
Sun Jul 01 00:00:00 EDT 2018
Frontline Science: Proliferation of Ly6C+ monocytes during urinary tract infections is regulated by IL-6 trans-signaling.
Journal of leukocyte biology
Dixit A,Bottek J,Beerlage AL,Schuettpelz J,Thiebes S,Brenzel A,Garbers C,Rose-John S,Mittrücker HW,Squire A,Engel DR
45-5932 was used in Immunohistochemistry to analyse the proliferative capacity of Ly6C+ monocytes in the urinary bladder after infection with uropathogenic Escherichia coli.
Mon Jan 01 00:00:00 EST 2018
Cytokine- and TCR-Mediated Regulation of T Cell Expression of Ly6C and Sca-1.
Journal of immunology (Baltimore, Md. : 1950)
DeLong JH,Hall AO,Konradt C,Coppock GM,Park J,Harms Pritchard G,Hunter CA
45-5932-82 was used in Flow Cytometry to highlight the TCR-dependent and cytokine-mediated signals that modulate T cell expression of Ly6C and Sca-1 in vitro and in vivo during infection.
Thu Mar 01 00:00:00 EST 2018
Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor 1 Shed by ADAM17 Drives Mouse Macrophage Proliferation in Acute and Chronic Inflammation.
Molecular and cellular biology
Tang J,Frey JM,Wilson CL,Moncada-Pazos A,Levet C,Freeman M,Rosenfeld ME,Stanley ER,Raines EW,Bornfeldt KE
45-5932 was used in Flow cytometry/Cell sorting to identify a significant defect in macrophage proliferation in mice lacking leukocyte transmembrane protease, ADAM17.
Sat Sep 01 00:00:00 EDT 2018
An IFNγ/CXCL2 regulatory pathway determines lesion localization during EAE.
Journal of neuroinflammation
Stoolman JS,Duncker PC,Huber AK,Giles DA,Washnock-Schmid JM,Soulika AM,Segal BM
45-5932 was used in Flow cytometry/Cell sorting to show a new mechanism by which IFNγ and CXCL2 interact to direct regional recruitment of leukocytes in the central nervous system.
Mon Jul 16 00:00:00 EDT 2018
MiR-486 promotes proliferation and suppresses apoptosis in myeloid cells by targeting Cebpa in vitro.
Cancer medicine
Jiang J,Gao Q,Gong Y,Huang L,Lin H,Zhou X,Liang X,Guo W
45-5932 was used in Flow cytometry/Cell sorting to identify micro-RNAs that regulate the proliferation and differentiation of monocytic myeloid-derived suppressor cells.
Sat Sep 01 00:00:00 EDT 2018
Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C- Cells.
Immunity
Mildner A,Schönheit J,Giladi A,David E,Lara-Astiaso D,Lorenzo-Vivas E,Paul F,Chappell-Maor L,Priller J,Leutz A,Amit I,Jung S
45-5932-82 was used in Flow Cytometry to characterise the population and single cell transcriptomes, as well as enhancer and promoter landscapes of the murine monocyte compartment.
Tue May 16 00:00:00 EDT 2017
IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model.
PLoS medicine
Xu J,Guardado J,Hoffman R,Xu H,Namas R,Vodovotz Y,Xu L,Ramadan M,Brown J,Turnquist HR,Billiar TR
45-5932 was used in Flow cytometry/Cell sorting to suggest that IL33 may initiate early detrimental type 2 immune responses after trauma through ILC2 regulation of neutrophil IL5 production.
Sat Jul 01 00:00:00 EDT 2017
Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing.
PLoS pathogens
Shenoy AT,Brissac T,Gilley RP,Kumar N,Wang Y,Gonzalez-Juarbe N,Hinkle WS,Daugherty SC,Shetty AC,Ott S,Tallon LJ,Deshane J,Tettelin H,Orihuela CJ
45-5932 was used in Flow cytometry/Cell sorting to show that biofilm pneumococci actively suppress the host response through pneumolysin-mediated immune cell killing.
Tue Aug 01 00:00:00 EDT 2017
Tumor Necrosis Factor Alpha-Induced Recruitment of Inflammatory Mononuclear Cells Leads to Inflammation and Altered Brain Development in Murine Cytomegalovirus-Infected Newborn Mice.
Journal of virology
Seleme MC,Kosmac K,Jonjic S,Britt WJ
45-5932 was used in Flow cytometry/Cell sorting to show that during cytomegalovirus (HCMV) infection in infants, tumor necrosis factor alpha plays a key role in brain inflammation and abnormal neurodevelopment. Targeting TNF-α with neutralising antibodies normalized neurodevelopment in infant mice.
Sat Apr 15 00:00:00 EDT 2017
Regulatory T Cells Promote Myositis and Muscle Damage in Toxoplasma gondii Infection.
Journal of immunology (Baltimore, Md. : 1950)
Jin RM,Blair SJ,Warunek J,Heffner RR,Blader IJ,Wohlfert EA
45-5932 was used in Flow cytometry/Cell sorting to study how the tissue environment established by Toxoplasma gondii leads to a pathogenic role for regulatory T cells.
Sun Jan 01 00:00:00 EST 2017
Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms.
Nature communications
Kim DS,Dastidar H,Zhang C,Zemp FJ,Lau K,Ernst M,Rakic A,Sikdar S,Rajwani J,Naumenko V,Balce DR,Ewanchuk BW,Tailor P,Yates RM,Jenne C,Gafuik C,Mahoney DJ
45-5932 was used in Flow cytometry/Cell sorting to show that SMC and OV therapies combination also synergize in vivo by promoting anticancer immunity through an increase in CD8(+) T-cell response.
Thu Aug 24 00:00:00 EDT 2017
Immunomodulatory nanoparticles ameliorate disease in the Leishmania (Viannia) panamensis mouse model.
Biomaterials
Siefert AL,Ehrlich A,Corral MJ,Goldsmith-Pestana K,McMahon-Pratt D,Fahmy TM
45-5932 was used in Flow cytometry/Cell sorting to study the therapeutic efficacy of biodegradable nanoparticles encapsulating a CpG-rich oligonucleotide in mice infected with Leishmania panamensis.
Tue Nov 01 00:00:00 EDT 2016
Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis.
PloS one
Giles DA,Moreno-Fernandez ME,Stankiewicz TE,Cappelletti M,Huppert SS,Iwakura Y,Dong C,Shanmukhappa SK,Divanovic S
45-5932 was used in Flow cytometry/Cell sorting to indicate that the IL-17 axis also plays a role in a MCDD-induced model of NAFLD pathogenesis.
Tue Jul 19 00:00:00 EDT 2016
Stroke sensitivity in the aged: sex chromosome complement vs. gonadal hormones.
Aging
McCullough LD,Mirza MA,Xu Y,Bentivegna K,Steffens EB,Ritzel R,Liu F
45-5932 was used in Flow cytometry/Cell sorting to conclude that the sex chromosome complement contributes to ischemic sensitivity in aged animals and causes differences in innate immune responses.
Fri Jul 01 00:00:00 EDT 2016
Ly6C(hi) Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis.
Cell reports
Möhle L,Mattei D,Heimesaat MM,Bereswill S,Fischer A,Alutis M,French T,Hambardzumyan D,Matzinger P,Dunay IR,Wolf SA
45-5932 was used in Flow cytometry/Cell sorting to detect that treatment of adult mice with antibiotics decreases hippocampal neurogenesis and memory retention.
Tue May 31 00:00:00 EDT 2016
Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis.
The Journal of experimental medicine
Nevius E,Pinho F,Dhodapkar M,Jin H,Nadrah K,Horowitz MC,Kikuta J,Ishii M,Pereira JP
45-5932 was used in Flow cytometry/Cell sorting to identify a novel pathway involved in osteoclast precursor homing to the bone surface that may have significant therapeutic potential.
Mon Oct 19 00:00:00 EDT 2015
Mast cells boost myeloid-derived suppressor cell activity and contribute to the development of tumor-favoring microenvironment.
Cancer immunology research
Danelli L,Frossi B,Gri G,Mion F,Guarnotta C,Bongiovanni L,Tripodo C,Mariuzzi L,Marzinotto S,Rigoni A,Blank U,Colombo MP,Pucillo CE
45-5932 was used in Flow cytometry/Cell sorting to examine the interactions between myeloid-derived suppressor cells and mast cells in the mucosa of patients with colon carcinoma.
Thu Jan 01 00:00:00 EST 2015
Early virus-host interactions dictate the course of a persistent infection.
PLoS pathogens
Sullivan BM,Teijaro JR,de la Torre JC,Oldstone MB
45-5932 was used in Flow cytometry/Cell sorting to investigate the very early host-virus interactions that determine the establishment of viral persistence.
Thu Jan 01 00:00:00 EST 2015
Diverse roles for T-bet in the effector responses required for resistance to infection.
Journal of immunology (Baltimore, Md. : 1950)
Harms Pritchard G,Hall AO,Christian DA,Wagage S,Fang Q,Muallem G,John B,Glatman Zaretsky A,Dunn WG,Perrigoue J,Reiner SL,Hunter CA
45-5932 was used in Flow cytometry/Cell sorting to highlight T-bet-independent pathways to IFN-γ production and reveal a novel role for this transcription factor in coordinating the T cell responses necessary to control infection in peripheral tissues.
Sun Feb 01 00:00:00 EST 2015
Apoptotic cell clearance of Leishmania major-infected neutrophils by dendritic cells inhibits CD8⁺ T-cell priming in vitro by Mer tyrosine kinase-dependent signaling.
Cell death & disease
Ribeiro-Gomes FL,Romano A,Lee S,Roffê E,Peters NC,Debrabant A,Sacks D
45-5932 was used in Flow cytometry/Cell sorting to define the clearance of infected neutrophils by dendritic cells as central to the early immune evasion strategies of L. major.
Thu Dec 10 00:00:00 EST 2015
Sexually dimorphic outcomes and inflammatory responses in hypoxic-ischemic encephalopathy.
Journal of neuroinflammation
Mirza MA,Ritzel R,Xu Y,McCullough LD,Liu F
45-5932 was used in Flow cytometry/Cell sorting to determine HIE leads to an equivalent primary brain injury in male and female neonates that develops into sexually dimorphic outcomes in later life.
Fri Feb 20 00:00:00 EST 2015
A Listeria vaccine and depletion of T-regulatory cells activate immunity against early stage pancreatic intraepithelial neoplasms and prolong survival of mice.
Gastroenterology
Keenan BP,Saenger Y,Kafrouni MI,Leubner A,Lauer P,Maitra A,Rucki AA,Gunderson AJ,Coussens LM,Brockstedt DG,Dubensky TW,Hassan R,Armstrong TD,Jaffee EM
45-5932 was used in Flow cytometry/Cell sorting to show that immunising KPC mice with Listeria monocytogenes expressing Kras(G12D), and depletion of Treg cells, reduces progression of early stage PanINs.
Sun Jun 01 00:00:00 EDT 2014
Foxp3+ CD4+ T cells improve healing after myocardial infarction by modulating monocyte/macrophage differentiation.
Circulation research
Weirather J,Hofmann UD,Beyersdorf N,Ramos GC,Vogel B,Frey A,Ertl G,Kerkau T,Frantz S
45-5932 was used in Flow cytometry/Cell sorting to determine the mechanisms by which regulatory T cells promote an appropriate healing response after a heart attack.
Fri Jun 20 00:00:00 EDT 2014
Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness.
Laboratory investigation; a journal of technical methods and pathology
Wang Y,Jin TH,Farhana A,Freeman J,Estell K,Zmijewski JW,Gaggar A,Thannickal VJ,Schwiebert LM,Steyn AJ,Deshane JS
45-5932 was used in Flow cytometry/Cell sorting to assess the effects of exposing myeloid-derived regulatory cells to cigarette smoke on the production of nitric oxide.
Mon Dec 01 00:00:00 EST 2014
Use of transgenic parasites and host reporters to dissect events that promote interleukin-12 production during toxoplasmosis.
Infection and immunity
Christian DA,Koshy AA,Reuter MA,Betts MR,Boothroyd JC,Hunter CA
45-5932 was used in Flow cytometry/Cell sorting to study the cell types which secrete IL-12p40 during Toxoplasma gondii infection.
Wed Oct 01 00:00:00 EDT 2014
Infection with Leishmania major induces a cellular stress response in macrophages.
PloS one
Filardy AA,Costa-da-Silva AC,Koeller CM,Guimarães-Pinto K,Ribeiro-Gomes FL,Lopes MF,Heise N,Freire-de-Lima CG,Nunes MP,DosReis GA
45-5932 was used in Flow cytometry/Cell sorting to investigate early cellular responses induced by infection with Leishmania major in macrophages from resistant C57/BL6 mice.
Mon Sep 08 00:00:00 EDT 2014
MHC class I-restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8⁺ T cells.
Nature immunology
Ji Q,Castelli L,Goverman JM
45-5932 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the role of CD8(+) T cells in the pathogenesis of multiple sclerosis.
Fri Mar 01 00:00:00 EST 2013
The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.
Nature immunology
Bell BD,Kitajima M,Larson RP,Stoklasek TA,Dang K,Sakamoto K,Wagner KU,Kaplan DH,Reizis B,Hennighausen L,Ziegler SF
45-5932 was used in Flow cytometry/Cell sorting to investigate how type-2 immunity is affected by STAT5 transcription factor in dendritic cells.
Mon Apr 01 00:00:00 EDT 2013
p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells.
The Journal of experimental medicine
Iannello A,Thompson TW,Ardolino M,Lowe SW,Raulet DH
45-5932 was used in Flow cytometry/Cell sorting to study how NK cells participate in the elimination of senescent tumours.
Mon Sep 23 00:00:00 EDT 2013
CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Ehrentraut H,Clambey ET,McNamee EN,Brodsky KS,Ehrentraut SF,Poth JM,Riegel AK,Westrich JA,Colgan SP,Eltzschig HK
45-5932 was used in Flow cytometry/Cell sorting to determine how CD73-dependent adenosine generation in Tregs promotes ALI resolution.
Sat Jun 01 00:00:00 EDT 2013
Mast cell-deficient Kit(W-sh) "Sash" mutant mice display aberrant myelopoiesis leading to the accumulation of splenocytes that act as myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950)
Michel A,Schüler A,Friedrich P,Döner F,Bopp T,Radsak M,Hoffmann M,Relle M,Distler U,Kuharev J,Tenzer S,Feyerabend TB,Rodewald HR,Schild H,Schmitt E,Becker M,Stassen M
45-5932 was used in Flow cytometry/Cell sorting to demonstrate the broad effects that the Kit(W-sh) mutation has on key steps in myelopoiesis.
Sat Jun 01 00:00:00 EDT 2013
Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue.
The Journal of biological chemistry
Patnode ML,Cheng CW,Chou CC,Singer MS,Elin MS,Uchimura K,Crocker PR,Khoo KH,Rosen SD
45-5932 was used in Flow cytometry/Cell sorting to investigate whether keratan sulfate galactose 6-O-sulfotransferase and chondroitin 6-O-sulfotransferase 1 are required for the generation of endogenous Siglec-F ligands.
Fri Sep 13 00:00:00 EDT 2013
Surgical manipulation compromises leukocyte mobilization responses and inflammation after experimental cerebral ischemia in mice.
Frontiers in neuroscience
Denes A,Pradillo JM,Drake C,Buggey H,Rothwell NJ,Allan SM
45-5932 was used in Flow cytometry/Cell sorting to show that experimental models of cerebral ischemia are compromised by surgery and anaesthesia.
Thu Jan 30 00:00:00 EST 2014
Efficient capture of infected neutrophils by dendritic cells in the skin inhibits the early anti-leishmania response.
PLoS pathogens
Ribeiro-Gomes FL,Peters NC,Debrabant A,Sacks DL
45-5932 was used in Flow cytometry/Cell sorting to study how exploitation of immunosuppressive effects by L.major following rapid uptake by skin neutrophils allows inhibition of acquired resistance.
Wed Feb 01 00:00:00 EST 2012
Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammation.
Immunology and cell biology
Lenzo JC,Turner AL,Cook AD,Vlahos R,Anderson GP,Reynolds EC,Hamilton JA
45-5932 was used in Flow cytometry/Cell sorting to determine how the hemopoietic growth factors, M-CSF or CSF-1, regulate their in vivo development and function.
Sun Apr 01 00:00:00 EDT 2012
Evaluation of recombinant Leishmania polyprotein plus glucopyranosyl lipid A stable emulsion vaccines against sand fly-transmitted Leishmania major in C57BL/6 mice.
Journal of immunology (Baltimore, Md. : 1950)
Peters NC,Bertholet S,Lawyer PG,Charmoy M,Romano A,Ribeiro-Gomes FL,Stamper LW,Sacks DL
45-5932 was used in Flow cytometry/Cell sorting to assess the immunity generated by recombinant Leishmania polyprotein with GLA vaccination following challenge with L. major.
Thu Nov 15 00:00:00 EST 2012
A critical role for SOCS3 in innate resistance to Toxoplasma gondii.
Cell host & microbe
Whitmarsh RJ,Gray CM,Gregg B,Christian DA,May MJ,Murray PJ,Hunter CA
45-5932 was used in Flow cytometry/Cell sorting to study the role of SOCS3 in suppressing IL-6 signalling during immune responses to T. gondii infection.
Thu Sep 15 00:00:00 EDT 2011
An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice.
The Journal of clinical investigation
Sindrilaru A,Peters T,Wieschalka S,Baican C,Baican A,Peter H,Hainzl A,Schatz S,Qi Y,Schlecht A,Weiss JM,Wlaschek M,Sunderkötter C,Scharffetter-Kochanek K
45-5932 was used in Flow cytometry/Cell sorting to study human subjects with chronic venous leg ulcers and devise a human and mouse disease model for macrophage-driven chronic inflammation.
Tue Mar 01 00:00:00 EST 2011
Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-associated macrophages.
Immunology
Buhtoiarov IN,Sondel PM,Wigginton JM,Buhtoiarova TN,Yanke EM,Mahvi DA,Rakhmilevich AL
45-5932 was used in Flow cytometry/Cell sorting to show that chemotherapy and anti-CD40 + CpG-ODN IT synergise in the induction of anti-tumour effects which are associated with the phenotypic repolarisation of tumour-associated Mφ.
Tue Feb 01 00:00:00 EST 2011
