Product References
TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation.
Nature communications
Worboys JD,Vowell KN,Hare RK,Ambrose AR,Bertuzzi M,Conner MA,Patel FP,Zammit WH,Gali-Moya J,Hazime KS,Jones KL,Rey C,Jonjic S,Rovis TL,Tannahill GM,Cruz De Matos GDS,Waight JD,Davis DM
16-0289-81 was used in Flow cytometry/Cell sorting to provide evidence that TIGIT directly inhibits lymphocyte activation, acting independently of CD226, requiring intracellular signalling that is proximal to the TCR.
Fri Aug 18 00:00:00 EDT 2023
Multiomics of Colorectal Cancer Organoids Reveals Putative Mediators of Cancer Progression Resulting from SMAD4 Inactivation.
Journal of proteome research
Dijkstra JJ,Neikes HK,Rezaeifard S,Ma X,Voest EE,Tauriello DVF,Vermeulen M
16-0289-81 was used in Sample prep to show that one of the factors that is specifically secreted by SMAD4-mutant organoids─DKK3─reduces the antitumor effects of natural killer cells (NK cells). Altogether, our data provide new insights into the role of SMAD4 perturbation in advanced CRC.
Fri Jan 06 00:00:00 EST 2023
A purine metabolic checkpoint that prevents autoimmunity and autoinflammation.
Cell metabolism
Saveljeva S,Sewell GW,Ramshorn K,Cader MZ,West JA,Clare S,Haag LM,de Almeida Rodrigues RP,Unger LW,Iglesias-Romero AB,Holland LM,Bourges C,Md-Ibrahim MN,Jones JO,Blumberg RS,Lee JC,Kaneider NC,Lawley TD,Bradley A,Dougan G,Kaser A
16-0289-81 was used in Flow Cytometry to understand the mechanism behind FAMIN's role in autoimmunity and autoinflammation whilst specifically looking at Still's disease.
Tue Jan 04 00:00:00 EST 2022
Cytotoxic T lymphocytes targeting a conserved SARS-CoV-2 spike epitope are efficient serial killers.
BioTechniques
Fathi M,Charley L,Cooper LJ,Varadarajan N,Meyer DD
16-0289-81 was used in Sample prep to study thousands of videos of T cells with specificity for SARS-CoV-2 eliminating targets bearing spike protein as a surrogate for viral infection.
Fri Apr 01 00:00:00 EDT 2022
IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike.
Frontiers in immunology
Gatineau J,Nidercorne C,Dupont A,Puiffe ML,Cohen JL,Molinier-Frenkel V,Niedergang F,Castellano F
16-0289-81 was used in Flow cytometry/Cell sorting to identify regions of homology between IL4I1 and spike and demonstrate competition between the two proteins for TMPRSS13 binding.
Fri Sep 23 00:00:00 EDT 2022
De novo generation of the NPM-ALK fusion recapitulates the pleiotropic phenotypes of ALK+ ALCL pathogenesis and reveals the ROR2 receptor as target for tumor cells.
Molecular cancer
Babin L,Darchen A,Robert E,Aid Z,Borry R,Soudais C,Piganeau M,De Cian A,Giovannangeli C,Bawa O,Rigaud C,Scoazec JY,Couronné L,Veleanu L,Cieslak A,Asnafi V,Sibon D,Lamant L,Meggetto F,Mercher T,Brunet E
16-0289-81 was used in Cell Culture to suggest that ALK+ ALCL cases with resistance to current therapies may also benefit from ROR2 targeting strategies.
Fri Mar 04 00:00:00 EST 2022
A reengineered common chain cytokine augments CD8+ T cell-dependent immunotherapy.
JCI insight
Banerjee A,Li D,Guo Y,Mei Z,Lau C,Chen K,Westwick J,Klauda JB,Schrum A,Lazear ER,Krupnick AS
16-0289-81 was used in Flow cytometry/Cell sorting to describe the signaling properties of a potentially unique cytokine by design, where T cell surface binding and signaling are separated between 2 different families of receptors.
Mon May 23 00:00:00 EDT 2022
Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ.
Aging cell
Webb LMC,Fra-Bido S,Innocentin S,Matheson LS,Attaf N,Bignon A,Novarino J,Fazilleau N,Linterman MA
16-0289-81 was used in Flow Cytometry to show increased formation of Tfh precursors (pre-Tfh) but no associated increase in germinal centre (GC)-Tfh cells in aged mice, suggesting age-driven promotion of only early Tfh cell differentiation.
Fri Jan 01 00:00:00 EST 2021
Downregulation of miRNA-451a Promotes the Differentiation of CD4+ T Cells towards Th2 Cells by Upregulating ETS1 in Childhood Asthma.
Journal of innate immunity
Wang T,Zhou Q,Shang Y
16-0289 was used in Flow cytometry/Cell sorting to investigate the role of miRNA-451a in regulating ETS1 expression in CD4+ T cell.
Thu Nov 11 00:00:00 EST 2021
Metabolic Defects of Peripheral T Cells in COVID-19 Patients.
Journal of immunology (Baltimore, Md. : 1950)
Liu X,Zhao J,Wang H,Wang W,Su X,Liao X,Zhang S,Sun J,Zhang Z
16-0289-81 was used in Flow Cytometry to characterise the metabolic profiles of resting and activated T cells from acutely infected and convalescent COVID-19 patients and confirmed the metabolic profiles.
Tue Jun 15 00:00:00 EDT 2021
Cyclooxygenase-2 expressed hepatocellular carcinoma induces cytotoxic T lymphocytes exhaustion through M2 macrophage polarization.
American journal of translational research
Xun X,Zhang C,Wang S,Hu S,Xiang X,Cheng Q,Li Z,Wang Y,Zhu J
16-0289-81 was used in Magnetic cell separation to investigate the COX-2-dependent immune regulation pathway.
Tue Jun 22 00:00:00 EDT 2021
Reciprocal regulation of interleukin-17A and interleukin-22 secretion through aryl hydrocarbon receptor activation in CD4+ T cells of patients with vitiligo.
Experimental and therapeutic medicine
Liu B,Xie Y,Mei X,Sun Y,Shi W,Wu Z
16-0289 was used in Flow cytometry/Cell sorting to determine the relationship between AhR activation and the secretion of IL17A and IL22 in CD4+ T cells in vitiligo.
Mon Feb 01 00:00:00 EST 2021
Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining.
Nature communications
Feldman T,Bercovich A,Moskovitz Y,Chapal-Ilani N,Mitchell A,Medeiros JJF,Biezuner T,Kaushansky N,Minden MD,Gupta V,Milyavsky M,Livneh Z,Tanay A,Shlush LI
16-0289-81 was used in Flow Cytometry to indicate an association between POLQ independent MMEJ and clonal hematopoiesis and elucidate mutational mechanisms involved in the very first steps of leukemia evolution.
Wed Apr 28 00:00:00 EDT 2021
Deciphering the state of immune silence in fatal COVID-19 patients.
Nature communications
Bost P,De Sanctis F,Canè S,Ugel S,Donadello K,Castellucci M,Eyal D,Fiore A,Anselmi C,Barouni RM,Trovato R,Caligola S,Lamolinara A,Iezzi M,Facciotti F,Mazzariol A,Gibellini D,De Nardo P,Tacconelli E,Gottin L,Polati E,Schwikowski B,Amit I,Bronte V
16-0289 was used in Flow cytometry/Cell sorting to show a COVID-19 immune signature associated with severity by integrating single-cell RNA-seq analysis from blood samples and broncho-alveolar lavage fluids with clinical, immunological and functional ex vivo data.
Fri Mar 05 00:00:00 EST 2021
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation.
Science immunology
Yan B,Freiwald T,Chauss D,Wang L,West E,Mirabelli C,Zhang CJ,Nichols EM,Malik N,Gregory R,Bantscheff M,Ghidelli-Disse S,Kolev M,Frum T,Spence JR,Sexton JZ,Alysandratos KD,Kotton DN,Pittaluga S,Bibby J,Niyonzima N,Olson MR,Kordasti S,Portilla D,Wobus CE,Laurence A,Lionakis MS,Kemper C,Afzali B,Kazemian M
16-0289-81 was used in Flow Cytometry to postulate that combination therapy with JAK inhibitors and drugs that normalize NF-κB-signaling could potentially have clinical application for severe COVID-19.
Wed Apr 07 00:00:00 EDT 2021
Immune cell profiling of the cerebrospinal fluid enables the characterization of the brain metastasis microenvironment.
Nature communications
Rubio-Perez C,Planas-Rigol E,Trincado JL,Bonfill-Teixidor E,Arias A,Marchese D,Moutinho C,Serna G,Pedrosa L,Iurlaro R,Martínez-Ricarte F,Escudero L,Cordero E,Cicuendez M,Ruiz S,Parra G,Nuciforo P,Gonzalez J,Pineda E,Sahuquillo J,Tabernero J,Heyn H,Seoane J
16-0289 was used in Flow cytometry/Cell sorting to characterize immune cells present in brain lesions and matched cerebrospinal fluid (CSF) using single-cell RNA sequencing combined with T cell receptor genotyping.
Mon Mar 08 00:00:00 EST 2021
Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.
Cancer discovery
Picco G,Cattaneo CM,van Vliet EJ,Crisafulli G,Rospo G,Consonni S,Vieira SF,Rodríguez IS,Cancelliere C,Banerjee R,Schipper LJ,Oddo D,Dijkstra KK,Cinatl J,Michaelis M,Yang F,Di Nicolantonio F,Sartore-Bianchi A,Siena S,Arena S,Voest EE,Bardelli A,Garnett MJ
16-0289-81 was used in Tumor Recognition Assayto inform the development of WRN as a therapeutic target, we performed WRN knockout or knockdown in 60 heterogeneous dMMR colorectal cancer preclinical models, demonstrating that WRN dependency is an almost universal feature and a robust marker for patient selection.
Sun Aug 01 00:00:00 EDT 2021
Multi-Omics Resolves a Sharp Disease-State Shift between Mild and Moderate COVID-19.
Cell
Su Y,Chen D,Yuan D,Lausted C,Choi J,Dai CL,Voillet V,Duvvuri VR,Scherler K,Troisch P,Baloni P,Qin G,Smith B,Kornilov SA,Rostomily C,Xu A,Li J,Dong S,Rothchild A,Zhou J,Murray K,Edmark R,Hong S,Heath JE,Earls J,Zhang R,Xie J,Li S,Roper R,Jones L,Zhou Y,Rowen L,Liu R,Mackay S,O'Mahony DS,Dale CR,Wallick JA,Algren HA,Zager MA,Wei W,Price ND,Huang S,Subramanian N,Wang K,Magis AT,Hadlock JJ,Hood L,Aderem A,Bluestone JA,Lanier LL,Greenberg PD,Gottardo R,Davis MM,Goldman JD,Heath JR
16-0289 was used in Flow cytometry/Cell sorting to show that moderate disease may provide the most effective setting for therapeutic intervention.
Thu Dec 10 00:00:00 EST 2020
Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer.
The Journal of clinical investigation
Salazar Y,Zheng X,Brunn D,Raifer H,Picard F,Zhang Y,Winter H,Guenther S,Weigert A,Weigmann B,Dumoutier L,Renauld JC,Waisman A,Schmall A,Tufman A,Fink L,Brüne B,Bopp T,Grimminger F,Seeger W,Pullamsetti SS,Huber M,Savai R
16-0289-81 was used in In vitro Assay to explore the effect of tumor-infiltrating lymphocyte subpopulations on lung cancer biology by studying in vitro cocultures, in vivo mouse models, and human lung cancer tissue. Lymphocyte conditioned media (CM) induced epithelial-mesenchymal transition (EMT) and migration in both primary human lung cancer cells and cell lines.
Wed Jul 01 00:00:00 EDT 2020
Tumor organoid-T-cell coculture systems.
Nature protocols
Cattaneo CM,Dijkstra KK,Fanchi LF,Kelderman S,Kaing S,van Rooij N,van den Brink S,Schumacher TN,Voest EE
16-0289-81 was used in Cell Culture to enable the establishment of ex vivo test systems for T-cell-based immunotherapy at the level of the individual patient.
Wed Jan 01 00:00:00 EST 2020
CD4 T cell-intrinsic role for the T helper 17 signature cytokine IL-17: Effector resistance to immune suppression.
Proceedings of the National Academy of Sciences of the United States of America
Crawford MP,Sinha S,Renavikar PS,Borcherding N,Karandikar NJ
16-0289-81 was used in ELISA to eveal a role for IL-17 cytokines in mediating CD4-intrinsic immune resistance.
Tue Aug 11 00:00:00 EDT 2020
JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction.
Cell death and differentiation
Simula L,Corrado M,Accordi B,Di Rita A,Nazio F,Antonucci Y,Di Daniele A,Caicci F,Caruana I,Soriano ME,Pigazzi M,Locatelli F,Cecconi F,Campello S
16-0289-81 was used in T-Cell Activation to find that Bim is also downregulated in T-cell Acute Lymphoblastic Leukemia (T-ALL) cells, this alteration favouring their escape from AICD-mediated control.
Thu Oct 01 00:00:00 EDT 2020
Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T-cell differentiation along the maternal-placental circulation.
Cell proliferation
Ma Y,Yang Q,Fan M,Zhang L,Gu Y,Jia W,Li Z,Wang F,Li YX,Wang J,Li R,Shao X,Wang YL
16-0289 was used in Flow cytometry/Cell sorting to study the TGF-β1 expression and distribution of regulatory T cells (Tregs) along the placental-maternal circulation route.
Fri May 01 00:00:00 EDT 2020
A Nonsense N -Terminus NFKB2 Mutation Leading to Haploinsufficiency in a Patient with a Predominantly Antibody Deficiency.
Journal of clinical immunology
Kuehn HS,Bernasconi A,Niemela JE,Almejun MB,Gallego WAF,Goel S,Stoddard JL,Sánchez RGP,Franco CAA,Oleastro M,Grunebaum E,Ballas Z,Cunningham-Rundles C,Fleisher TA,Franco JL,Danielian S,Rosenzweig SD
16-0289 was used in Flow cytometry/Cell sorting to demonstrate that bona fide NFKB2 haploinsufficiency is associated with clinical immunodeficiency.
Sun Nov 01 00:00:00 EDT 2020
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.
The Journal of cell biology
Xu X,Hou B,Fulzele A,Masubuchi T,Zhao Y,Wu Z,Hu Y,Jiang Y,Ma Y,Wang H,Bennett EJ,Fu G,Hui E
16-0289-81 was used in Western Blot, Flow Cytometry to compare the abilities of BTLA and PD-1 to recruit effector molecules and to regulate T cell signalling.
Mon Jun 01 00:00:00 EDT 2020
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.
The Journal of cell biology
Xu X,Hou B,Fulzele A,Masubuchi T,Zhao Y,Wu Z,Hu Y,Jiang Y,Ma Y,Wang H,Bennett EJ,Fu G,Hui E
16-0289-81 was used in Western Blot, Flow Cytometry to compare the abilities of BTLA and PD-1 to recruit effector molecules and to regulate T cell signalling.
Mon Jun 01 00:00:00 EDT 2020
Inhibition of Glycolysis in Pathogenic TH17 Cells through Targeting a miR -21-Peli1-c-Rel Pathway Prevents Autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Qiu R,Yu X,Wang L,Han Z,Yao C,Cui Y,Hou G,Dai D,Jin W,Shen N
16-0289-81 was used in Functional assay to investigate if CNS-infiltrated pathogenic TH17 cells from diseased mice specifically upregulate glycolytic pathway genes compared with homeostatic intestinal TH17 cells.
Mon Jun 15 00:00:00 EDT 2020
IL-10 Restores MHC Class I Expression and Interferes With Immunity in Papillary Thyroid Cancer With Hashimoto Thyroiditis.
Endocrinology
Lu ZW,Hu JQ,Liu WL,Wen D,Wei WJ,Wang YL,Wang Y,Liao T,Ji QH
16-0289 was used in Flow cytometry/Cell sorting to investigate whether IL-10 interferes tumor immunity in PTC with concomitant HT.
Thu Oct 01 00:00:00 EDT 2020
IL-2 enhanced MHC class I expression in papillary thyroid cancer with Hashimoto's thyroiditis overcomes immune escape in vitro.
Journal of Cancer
Hu JQ,Lei BW,Wen D,Ma B,Zhang TT,Lu ZW,Wei WJ,Wang YL,Wang Y,Li DS,Ji QH,Liao T
16-0289 was used in Flow cytometry/Cell sorting to investigate the effect of IL-2 on MHC class I expression in PTC cells and immune activation with experimental treatment for PTC using PTC cell lines.
Mon Sep 28 00:00:00 EDT 2020
Prostaglandin E2 Reverses the Effects of DNA Methyltransferase Inhibitor and TGFB1 on the Conversion of Naive T Cells to iTregs.
Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie
Sahin M,Sahin E
16-0289-81 was used in In vitro Assay to examine whether PGE2 contributes to the formation of iTregs treated with TGFB1 and 5-aza-2'-deoxycytidine (5-aza-dC).
Mon Jun 01 00:00:00 EDT 2020
The MicroRNA miR-22 Represses Th17 Cell Pathogenicity by Targeting PTEN-Regulated Pathways.
ImmunoHorizons
Wang L,Qiu R,Zhang Z,Han Z,Yao C,Hou G,Dai D,Jin W,Tang Y,Yu X,Shen N
16-0289-81 was used in In vitro Assay to identify that Th17 cell-intrinsic miR-22 could protect mice from autoimmunity by targeting PTEN-regulated pathways.
Tue Jun 09 00:00:00 EDT 2020
IL-12-Induced Immune Suppressive Deficit During CD8+ T-Cell Differentiation.
Frontiers in immunology
Renavikar PS,Sinha S,Brate AA,Borcherding N,Crawford MP,Steward-Tharp SM,Karandikar NJ
16-0289 was used in Flow cytometry/Cell sorting to provide insights into the role of T-cell differentiation in CD8 suppressive biology and may reveal therapeutically targetable pathways to reverse suppressive deficit during immune-mediated disease.
Thu May 13 00:00:00 EDT 2021
Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses.
Nature communications
Evans RDR,Antonelou M,Sathiananthamoorthy S,Rega M,Henderson S,Ceron-Gutierrez L,Barcenas-Morales G,Müller CA,Doffinger R,Walsh SB,Salama AD
16-0289 was used in Flow cytometry/Cell sorting to investigate immunity in patients with inherited salt-losing tubulopathies (SLT).
Mon Aug 31 00:00:00 EDT 2020
CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation.
JCI insight
Beckermann KE,Hongo R,Ye X,Young K,Carbonell K,Healey DCC,Siska PJ,Barone S,Roe CE,Smith CC,Vincent BG,Mason FM,Irish JM,Rathmell WK,Rathmell JC
16-0289 was used in Flow cytometry/Cell sorting to show that CD28+ costimulation is involved in activation and effector functions of CD8+ renal cell carcinoma tumour-infiltrating lymphocytes.
Thu Aug 20 00:00:00 EDT 2020
The novel multi-cytokine inhibitor TO-207 specifically inhibits pro-inflammatory cytokine secretion in monocytes without affecting the killing ability of CAR T cells.
PloS one
Futami M,Suzuki K,Kato S,Ohmae S,Tahara Y,Nojima M,Imai Y,Mimura T,Watanabe Y,Tojo A
16-0289 was used in Flow cytometry/Cell sorting to investigate whether TO-207 could inhibit cytokine production without impairing CAR T cell function in a CRS-simulating co-culture system.
Mon Jul 20 00:00:00 EDT 2020
RAB11FIP5-Deficient Mice Exhibit Cytokine-Related Transcriptomic Signatures.
ImmunoHorizons
Li D,Bradley T,Cain DW,Pedroza-Pacheco I,Aggelakopoulou M,Parks R,Barr M,Xia SM,Scearce R,Bowman C,Stevens G,Newman A,Hora B,Chen Y,Riebe K,Wang Y,Sempowski G,Saunders KO,Borrow P,Haynes BF
16-0289-81 was used in T-Cell Activation to study the role of Rab11Fip5 in immune responses.
Tue Nov 10 00:00:00 EST 2020
Reversal of pre-existing NGFR-driven tumor and immune therapy resistance.
Nature communications
Boshuizen J,Vredevoogd DW,Krijgsman O,Ligtenberg MA,Blankenstein S,de Bruijn B,Frederick DT,Kenski JCN,Parren M,Brüggemann M,Madu MF,Rozeman EA,Song JY,Horlings HM,Blank CU,van Akkooi ACJ,Flaherty KT,Boland GM,Peeper DS
16-0289-81 was used in T-Cell Activation to demonstrate the existence of a stable and pre-existing NGFRhi multitherapy-refractory melanoma subpopulation.
Fri Aug 07 00:00:00 EDT 2020
Mesenchymal Stem and Stromal Cells Harness Macrophage-Derived Amphiregulin to Maintain Tissue Homeostasis.
Cell reports
Ko JH,Kim HJ,Jeong HJ,Lee HJ,Oh JY
16-0289-81 was used in Functional assay to demonstrate the role of mesenchymal stem and stromal cell and macrophage cross-talk in post-injury tissue homeostasis in mice.
Tue Mar 17 00:00:00 EDT 2020
Oxidation of HMGB1 Is a Dynamically Regulated Process in Physiological and Pathological Conditions.
Frontiers in immunology
Ferrara M,Chialli G,Ferreira LM,Ruggieri E,Careccia G,Preti A,Piccirillo R,Bianchi ME,Sitia G,Venereau E
16-0289 was used in Western Blotting to analyze the expression of HMGB1 redox isoforms in different inflammatory conditions in skeletal muscle.
Mon Apr 05 00:00:00 EDT 2021
DNA hypomethylation promotes transposable element expression and activation of immune signaling in renal cell cancer.
JCI insight
de Cubas AA,Dunker W,Zaninovich A,Hongo RA,Bhatia A,Panda A,Beckermann KE,Bhanot G,Ganesan S,Karijolich J,Rathmell WK
16-0289 was used in Flow cytometry/Cell sorting to identify a potential strategy to induce TE expression through inhibition of DNA methylation in modulating T cell action via regulation of the innate antiviral pathway.
Thu Jun 04 00:00:00 EDT 2020
Regulatory T cell features in chronic granulomatous disease.
Clinical and experimental immunology
van de Geer A,Cuadrado E,Slot MC,van Bruggen R,Amsen D,Kuijpers TW
16-0289-81 was used in Cell Culture to investigate whether numerical or functional deficiencies exist in Tregs of patients with chronic granulomatous disease.
Thu Aug 01 00:00:00 EDT 2019
Fetal T Cell Activation in the Amniotic Cavity during Preterm Labor: A Potential Mechanism for a Subset of Idiopathic Preterm Birth.
Journal of immunology (Baltimore, Md. : 1950)
Gomez-Lopez N,Romero R,Xu Y,Miller D,Arenas-Hernandez M,Garcia-Flores V,Panaitescu B,Galaz J,Hsu CD,Para R,Berry SM
16-0289 was used in Flow cytometry/Cell sorting to show that fetal T cells are a predominant leukocyte population in amniotic fluid during preterm gestrations, and that chord blood T cells obtained from women with idiopathic preterm labor and birth displayed enhanced ex vivo activation.
Tue Oct 01 00:00:00 EDT 2019
An increase in circulating B cells and B cell activation markers in peripheral blood is associated with cigarette smoking in a male cohort in Bangladesh.
Toxicology and applied pharmacology
Burchiel SW,Lauer FT,Factor-Litvak P,Liu X,Santella RM,Islam T,Eunus M,Alam N,Islam T,Rahman M,Ahmed A,Ahsan H,Graziano J,Parvez F
16-0289-81 was used in Cell Culture to demonstrate activation of the immune system during chronic exposure to cigarette smoke, which is a known risk factor for autoimmune diseases.
Sun Dec 01 00:00:00 EST 2019
Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cells.
PloS one
Tanaskovic O,Verga Falzacappa MV,Pelicci PG
16-0289 was used in Functional assays to suggest that (hCB)-CD34+ NSG mice are transient and/or incomplete carriers of the human immune system and, therefore, represent a suboptimal tool to study the interaction between tumor and immune cells.
Wed Mar 11 00:00:00 EDT 2020
Determining the extent of maternal-foetal chimerism in cord blood.
Scientific reports
Opstelten R,Slot MC,Lardy NM,Lankester AC,Mulder A,Claas FHJ,van Rood JJ,Amsen D
16-0289 was used in Flow cytometry/Cell sorting to aim to functionally characterise maternal T cells from cord blood.
Wed Mar 27 00:00:00 EDT 2019
Clinical significance of CD8+ T cell immunoreceptor with Ig and ITIM domains+ in locally advanced gastric cancer treated with SOX regimen after D2 gastrectomy.
Oncoimmunology
Tang W,Pan X,Han D,Rong D,Zhang M,Yang L,Ying J,Guan H,Chen Z,Wang X
16-0289-81 was used in T-Cell Activation to investigate the influence of SOX regimen and TIGIT functional antibody on CD8 tumor-infiltrating lymphocytes (TILs).
Tue Jan 12 00:00:00 EST 2021
IL-17A increases MHC class I expression and promotes T cell activation in papillary thyroid cancer patients with coexistent Hashimoto's thyroiditis.
Diagnostic pathology
Han LT,Hu JQ,Ma B,Wen D,Zhang TT,Lu ZW,Wei WJ,Wang YL,Wang Y,Liao T,Ji QH
16-0289 was used in Flow cytometry/Cell sorting to demonstrate papillary thyroid cancer with coexisting Hashimoto's thyroiditis displays enhanced T cell activation and MHC class I expression due to interleukin-17A.
Tue Jun 04 00:00:00 EDT 2019
Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids.
Cell
Dijkstra KK,Cattaneo CM,Weeber F,Chalabi M,van de Haar J,Fanchi LF,Slagter M,van der Velden DL,Kaing S,Kelderman S,van Rooij N,van Leerdam ME,Depla A,Smit EF,Hartemink KJ,de Groot R,Wolkers MC,Sachs N,Snaebjornsson P,Monkhorst K,Haanen J,Clevers H,Schumacher TN,Voest EE
16-0289-81 was used in Flow Cytometry to describe a platform to induce and analyze tumor-specific T cell responses to epithelial cancers in a personalized manner.
Thu Sep 06 00:00:00 EDT 2018
Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity.
Immunity
Cuadrado E,van den Biggelaar M,de Kivit S,Chen YY,Slot M,Doubal I,Meijer A,van Lier RAW,Borst J,Amsen D
16-0289 was used in Flow cytometry/Cell sorting to suggest that adaptation in signaling pathways protect Treg cell identity and present a resource for further research into Treg cell biology.
Tue May 15 00:00:00 EDT 2018
The Effects of High Mobility Group Box-1 Protein on Peripheral Treg/Th17 Balance in Patients with Atherosclerosis.
Acta Cardiologica Sinica
Ding JW,Zhou T,Zheng XX,Wang XA,Tong XH,Luo CY,Zhang ZQ,Yu B
16-0289 was used in Functional assays to explore the mechanism of regulatory T cell/Th17 imbalance and the role of high mobility group box-1 protein on the balance in atherosclerosis.
Sat Sep 01 00:00:00 EDT 2018
Human T2R38 Bitter Taste Receptor Expression in Resting and Activated Lymphocytes.
Frontiers in immunology
Tran HTT,Herz C,Ruf P,Stetter R,Lamy E
16-0289 was used in Flow cytometry/Cell sorting to study T2R38 expression in resting and activated lymphocytes and T cell populations.
Wed Oct 09 00:00:00 EDT 2019
Description of organ-specific phenotype, and functional characteristics of tissue resident lymphocytes from liver transplantation donor and research on immune tolerance mechanism of liver.
Oncotarget
Shi Y,Zhang P,Wang G,Liu X,Sun X,Zhang X,Li H,Qi J,Ding L,Li T,Zhang R,Chen Y,Zhou J,Lv G,Tu Z
16-0289 was used in Flow cytometry/Cell sorting to study the phenotype and function of tissue resident lymphocytes in peripheral blood, lymph node, spleen and liver.
Tue Mar 20 00:00:00 EDT 2018
A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation.
Nature communications
Compeer EB,Kraus F,Ecker M,Redpath G,Amiezer M,Rother N,Nicovich PR,Kapoor-Kaushik N,Deng Q,Samson GPB,Yang Z,Lou J,Carnell M,Vartoukian H,Gaus K,Rossy J
Mon Apr 23 00:00:00 EDT 2018
Comparison between 8-methoxypsoralen and 5-aminolevulinic acid in killing T cells of photopheresis patients ex vivo.
Lasers in surgery and medicine
Holien T,Gederaas OA,Darvekar SR,Christensen E,Peng Q
16-0289-81 was used in Flow Cytometry, Functional Assay, In Vitro Assay to suggest that 5-ALA/UV-A may have the potential for improving the efficacy of ECP.
Sun Jul 01 00:00:00 EDT 2018
Immunological Properties of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells.
Stem cell reports
Idelson M,Alper R,Obolensky A,Yachimovich-Cohen N,Rachmilewitz J,Ejzenberg A,Beider E,Banin E,Reubinoff B
16-0289 was used in Flow cytometry/Cell sorting to analyse the immunomodulatory properties of human embryonic stem cells-derived retinal pigment epithelium cells, and showed that they inhibit T cell responses.
Tue Sep 11 00:00:00 EDT 2018
Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Cell reports
Li Y,Tan S,Zhang C,Chai Y,He M,Zhang CW,Wang Q,Tong Z,Liu K,Lei Y,Liu WJ,Liu Y,Tian Z,Cao X,Yan J,Qi J,Tien P,Gao S,Gao GF
16-0289-81 was used in Western Blot to show insight into the binding of 4-1BB with its ligand and its agonist mAb.
Tue Oct 23 00:00:00 EDT 2018
An Immune Atlas of Clear Cell Renal Cell Carcinoma.
Cell
Chevrier S,Levine JH,Zanotelli VRT,Silina K,Schulz D,Bacac M,Ries CH,Ailles L,Jewett MAS,Moch H,van den Broek M,Beisel C,Stadler MB,Gedye C,Reis B,Pe'er D,Bodenmiller B
16-0289 was used in Mass cytometry to identify potential biomarkers and targets for immunotherapy development, and validate tools that can be used for immune profiling of other tumour types.
Thu May 04 00:00:00 EDT 2017
Pooled CRISPR screening with single-cell transcriptome readout.
Nature methods
Datlinger P,Rendeiro AF,Schmidl C,Krausgruber T,Traxler P,Klughammer J,Schuster LC,Kuchler A,Alpar D,Bock C
16-0289 was used in Functional assays to combine pooled CRISPR screening with single-cell RNA sequencing, directly linking guide RNA expression to transcriptome responses in thousands of individual cells.
Wed Mar 01 00:00:00 EST 2017
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.
Cell stem cell
Carcamo-Orive I,Hoffman GE,Cundiff P,Beckmann ND,D'Souza SL,Knowles JW,Patel A,Papatsenko D,Abbasi F,Reaven GM,Whalen S,Lee P,Shahbazi M,Henrion MYR,Zhu K,Wang S,Roussos P,Schadt EE,Pandey G,Chang R,Quertermous T,Lemischka I
Thu Apr 06 00:00:00 EDT 2017
Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells.
The Journal of allergy and clinical immunology
Chen HH,Händel N,Ngeow J,Muller J,Hühn M,Yang HT,Heindl M,Berbers RM,Hegazy AN,Kionke J,Yehia L,Sack U,Bläser F,Rensing-Ehl A,Reifenberger J,Keith J,Travis S,Merkenschlager A,Kiess W,Wittekind C,Walker L,Ehl S,Aretz S,Dustin ML,Eng C,Powrie F,Uhlig HH
16-0289 was used in Functional assays to investigate Treg cells in patients with heterozygous germline PTEN mutations, showing a significant effect on T- and B-cell immunity.
Wed Feb 01 00:00:00 EST 2017
Screening of an FDA-approved compound library identifies levosimendan as a novel anti-HIV-1 agent that inhibits viral transcription.
Antiviral research
Hayashi T,Jean M,Huang H,Simpson S,Santoso NG,Zhu J
16-0289 was used in Functional assays to identify levosimendan as a novel and promising anti-HIV-1 inhibitor.
Sun Oct 01 00:00:00 EDT 2017
A Novel Bromodomain Inhibitor Reverses HIV-1 Latency through Specific Binding with BRD4 to Promote Tat and P-TEFb Association.
Frontiers in microbiology
Huang H,Liu S,Jean M,Simpson S,Huang H,Merkley M,Hayashi T,Kong W,Rodríguez-Sánchez I,Zhang X,Yosief HO,Miao H,Que J,Kobie JJ,Bradner J,Santoso NG,Zhang W,Zhu J
16-0289 was used in Functional assays to evaluate the potency of UMB-32 based methyl-triazolo bromodomain, and extra-terminal domain inhibitors as potential new latency-reversing agents.
Thu Oct 01 00:00:00 EDT 2020
RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization.
Cell death & disease
Meng YH,Zhou WJ,Jin LP,Liu LB,Chang KK,Mei J,Li H,Wang J,Li DJ,Li MQ
16-0289 was used in Functional assays to investigate the effect of RANKL from human embryonic trophoblasts and maternal decidual stromal cells on decidual macrophage differentiation and maternal-fetal immune tolerance.
Thu Oct 12 00:00:00 EDT 2017
Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination.
Proceedings of the National Academy of Sciences of the United States of America
Pageon SV,Tabarin T,Yamamoto Y,Ma Y,Nicovich PR,Bridgeman JS,Cohnen A,Benzing C,Gao Y,Crowther MD,Tungatt K,Dolton G,Sewell AK,Price DA,Acuto O,Parton RG,Gooding JJ,Rossy J,Rossjohn J,Gaus K
16-0289 was used in Functional assays to investigate how TCR-CD3 clusters can translate antigen recognition into signal initiation, and how cluster formation is a process of antigen discrimination.
Tue Sep 13 00:00:00 EDT 2016
CD16+ Monocyte Subset Was Enriched and Functionally Exacerbated in Driving T-Cell Activation and B-Cell Response in Systemic Lupus Erythematosus.
Frontiers in immunology
Zhu H,Hu F,Sun X,Zhang X,Zhu L,Liu X,Li X,Xu L,Shi L,Gan Y,Su Y
16-0289 was used in Flow cytometry/Cell sorting to demonstrate that CD16+monocytes were enriched and played a critical role in driving the pathogenic T- and B-cell responses in patients with systemic lupus erythematosus.
Wed Nov 20 00:00:00 EST 2019
A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes.
PLoS pathogens
Jones RB,Mueller S,O'Connor R,Rimpel K,Sloan DD,Karel D,Wong HC,Jeng EK,Thomas AS,Whitney JB,Lim SY,Kovacs C,Benko E,Karandish S,Huang SH,Buzon MJ,Lichterfeld M,Irrinki A,Murry JP,Tsai A,Yu H,Geleziunas R,Trocha A,Ostrowski MA,Irvine DJ,Walker BD
16-0289 was used in Functional assays to determine the efficacy of different latency-reversing agents in sensitising latency-infected cells or recognition by HIV-specific CD8+ T-cells, showing a subset of latency-reversing agents expose latency-infected cells for recognition.
Fri Apr 01 00:00:00 EDT 2016
Discovery and characterization of COVA322, a clinical-stage bispecific TNF/IL-17A inhibitor for the treatment of inflammatory diseases.
mAbs
Silacci M,Lembke W,Woods R,Attinger-Toller I,Baenziger-Tobler N,Batey S,Santimaria R,von der Bey U,Koenig-Friedrich S,Zha W,Schlereth B,Locher M,Bertschinger J,Grabulovski D
16-0289 was used in Functional assays to investigate the use of dual TNF/IL-17A inhibition to treat rheumatoid arthritis.
Fri Sep 30 00:00:00 EDT 2016
Clus-DoC: a combined cluster detection and colocalization analysis for single-molecule localization microscopy data.
Molecular biology of the cell
Pageon SV,Nicovich PR,Mollazade M,Tabarin T,Gaus K
16-0289 was used in Functional assays to develop Clus-DoC, an analysis strategy that quantifies both the spatial distribution of a protein and its colocalization status.
Mon Nov 07 00:00:00 EST 2016
Simultaneous, Single-Cell Measurement of Messenger RNA, Cell Surface Proteins, and Intracellular Proteins.
Current protocols in cytometry
Soh KT,Tario JD,Colligan S,Maguire O,Pan D,Minderman H,Wallace PK
16-0289 was used in Flow cytometry/Cell sorting to develop a protocol for the simultaneous, single-cell measurement of mRNA, cell surface proteins, and intracellular proteins.
Wed Jan 06 00:00:00 EST 2016
Genomic landscape of cutaneous T cell lymphoma.
Nature genetics
Choi J,Goh G,Walradt T,Hong BS,Bunick CG,Chen K,Bjornson RD,Maman Y,Wang T,Tordoff J,Carlson K,Overton JD,Liu KJ,Lewis JM,Devine L,Barbarotta L,Foss FM,Subtil A,Vonderheid EC,Edelson RL,Schatz DG,Boggon TJ,Girardi M,Lifton RP
16-0289 was used in Flow cytometry/Cell sorting to implicate mutations in 17 genes in CTCL pathogenesis, including genes involved in T cell activation and apoptosis, NF-κB signaling, chromatin remodeling and DNA damage response.
Tue Sep 01 00:00:00 EDT 2015
Soluble PD-1 aggravates progression of collagen-induced arthritis through Th1 and Th17 pathways.
Arthritis research & therapy
Liu C,Jiang J,Gao L,Wang X,Hu X,Wu M,Wu J,Xu T,Shi Q,Zhang X
16-0289 was used in Functional assays to study the role of soluble programmed death 1 (sPD-1) protein in the regulation of rheumatoid arthritis, showing that serum levels of sPD-1 were significantly correlated with titres of rheumatoid factor, and that it functionally blocked the inhibitory effect of PD-1 on T-cell activation, suggesting that sPD-1 may represent a biomarker or targer for rheumatoid arthritis.
Wed Nov 25 00:00:00 EST 2015
IL-10 Potentiates Differentiation of Human Induced Regulatory T Cells via STAT3 and Foxo1.
Journal of immunology (Baltimore, Md. : 1950)
Hsu P,Santner-Nanan B,Hu M,Skarratt K,Lee CH,Stormon M,Wong M,Fuller SJ,Nanan R
16-0289 was used in Flow cytometry/Cell sorting to investigate the action of IL-10 on regulatory T cells, and the potential therapeutic implications for the treatment of immune diseases that this may hold.
Thu Oct 15 00:00:00 EDT 2015
Helios, and not FoxP3, is the marker of activated Tregs expressing GARP/LAP.
Oncotarget
Elkord E,Abd Al Samid M,Chaudhary B
16-0289 was used in Flow cytometry/Cell sorting to define reliable and specific markers that can distinguish different Treg subpopulations.
Fri Aug 21 00:00:00 EDT 2015
Induced expression of FcγRIIIa (CD16a) on CD4+ T cells triggers generation of IFN-γhigh subset.
The Journal of biological chemistry
Chauhan AK,Chen C,Moore TL,DiPaolo RJ
16-0289 was used in Functional assays to describe for the first time a role for FcγRIIIa in CD4+ T-cell differentiation.
Fri Feb 20 00:00:00 EST 2015
Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients.
The Journal of clinical investigation
McDonald G,Deepak S,Miguel L,Hall CJ,Isenberg DA,Magee AI,Butters T,Jury EC
16-0289 was used in in vitro experiments to identify the defects in lymphocyte signalling and function that contribute to the pathogenesis of systemic lupus erythematosus.
Sat Feb 01 00:00:00 EST 2014
Alternative capture of noncoding RNAs or protein-coding genes by herpesviruses to alter host T cell function.
Molecular cell
Guo YE,Riley KJ,Iwasaki A,Steitz JA
16-0289 was used in Flow cytometry/Cell sorting to demonstrate that oncogenic γ-herpesviruses have evolved diverse strategies to converge on common targets in host T cells.
Thu Apr 10 00:00:00 EDT 2014
A CD8 T cell/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus.
Arthritis & rheumatology (Hoboken, N.J.)
Wang D,Feng X,Lu L,Konkel JE,Zhang H,Chen Z,Li X,Gao X,Lu L,Shi S,Chen W,Sun L
16-0289 was used in Functional assays to highlight a previously unrecognised CD8+ T cell/IFNγ/IDO axis that mediates the therapeutic effects of allogeneic MSCs in lupus patients.
Fri Aug 01 00:00:00 EDT 2014
Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Hartmann N,Giese NA,Giese T,Poschke I,Offringa R,Werner J,Ryschich E
16-0289 was used in Flow cytometry/Cell sorting to analyse how chemokines and extracellular matrix collagen interact in mediating T-cell infiltration in pancreatic ductal adenocarcinoma.
Tue Jul 01 00:00:00 EDT 2014
Human CD4+ HLA-G+ regulatory T cells are potent suppressors of graft-versus-host disease in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Pankratz S,Bittner S,Herrmann AM,Schuhmann MK,Ruck T,Meuth SG,Wiendl H
16-0289 was used in an ELISA assay to compare properties and molecular characteristics of human CD4(+) Treg cells using in vitro and in vivo studies.
Fri Aug 01 00:00:00 EDT 2014
Human CD4+ HLA-G+ regulatory T cells are potent suppressors of graft-versus-host disease in vivo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Pankratz S,Bittner S,Herrmann AM,Schuhmann MK,Ruck T,Meuth SG,Wiendl H
16-0289 was used in an ELISA assay to compare properties and molecular characteristics of human CD4(+) Treg cells using in vitro and in vivo studies.
Fri Aug 01 00:00:00 EDT 2014
Immunosuppressive activity of an aqueous Viola tricolor herbal extract.
Journal of ethnopharmacology
Hellinger R,Koehbach J,Fedchuk H,Sauer B,Huber R,Gruber CW,Gründemann C
16-0289 was used in Functional assays to provide a rationale for use of herbal Viola preparations in the therapy of disorders related to an overactive immune system.
Mon Sep 08 00:00:00 EDT 2014
Tumor-activated TCRγδ⁺ T cells from gastric cancer patients induce the antitumor immune response of TCRαβ⁺ T cells via their antigen-presenting cell-like effects.
Journal of immunology research
Mao C,Mou X,Zhou Y,Yuan G,Xu C,Liu H,Zheng T,Tong J,Wang S,Chen D
16-0289 was used in in vitro experiments to study how tumour-activated γδ T cells may induce adaptive immune responses through their APC-like functions.
Wed Jan 07 00:00:00 EST 2015
Cell-based measurements of mitochondrial function in human subjects.
Methods in enzymology
Kang JG,Wang PY,Hwang PM
16-0289 was used in Functional assays to describe methods for measuring the mitochondrial metabolism of blood lymphocytes and skeletal muscle myoblasts.
Tue May 26 00:00:00 EDT 2015
N-glycosylation of asparagine 8 regulates surface expression of major histocompatibility complex class I chain-related protein A (MICA) alleles dependent on threonine 24.
The Journal of biological chemistry
Mellergaard M,Skovbakke SL,Schneider CL,Lauridsen F,Andresen L,Jensen H,Skov S
16-0289 was used in Functional assays to determine the specific mode of regulation of NKG2D ligand surface expression by N-glycosylation.
Fri Jul 18 00:00:00 EDT 2014
Thrombospondin-1 is a CD47-dependent endogenous inhibitor of hydrogen sulfide signaling in T cell activation.
Matrix biology : journal of the International Society for Matrix Biology
Miller TW,Kaur S,Ivins-O'Keefe K,Roberts DD
16-0289 was used in Functional assays to investigate the mechanism of inhibition of T cell activation by thrombospondin-1.
Thu Aug 08 00:00:00 EDT 2013
Human neonatal naive CD4+ T cells have enhanced activation-dependent signaling regulated by the microRNA miR-181a.
Journal of immunology (Baltimore, Md. : 1950)
Palin AC,Ramachandran V,Acharya S,Lewis DB
16-0289 was used in Functional assays to investigate the developmental differences in immune function between human neonates and adults, showing that neonatal naive CD4+ T cells have enhanced activation-dependent signalling.
Fri Mar 15 00:00:00 EDT 2013
An efficient low cost method for gene transfer to T lymphocytes.
PloS one
Chicaybam L,Sodre AL,Curzio BA,Bonamino MH
16-0289 was used in Functional assays to describe a novel protocol for electroporation based modification of T lymphocytes.
Mon Sep 30 00:00:00 EDT 2013
GFP affects human T cell activation and cytokine production following in vitro stimulation.
PloS one
Koelsch KA,Wang Y,Maier-Moore JS,Sawalha AH,Wren JD
16-0289 was used in Functional assays to explore and characterise the effects of TurboGFP on the activation of primary T cells.
Tue Oct 22 00:00:00 EDT 2013
Crucial role of granulocytic myeloid-derived suppressor cells in the regulation of central nervous system autoimmune disease.
Journal of immunology (Baltimore, Md. : 1950)
Ioannou M,Alissafi T,Lazaridis I,Deraos G,Matsoukas J,Gravanis A,Mastorodemos V,Plaitakis A,Sharpe A,Boumpas D,Verginis P
16-0289 was used in Flow cytometry/Cell sorting to study granulocytic myeloid-derived suppressor cells in the natural resolution of experimental autoimmune encephalomyelitis in mice.
Wed Feb 01 00:00:00 EST 2012
The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin.
PloS one
Qi Y,Operario DJ,Georas SN,Mosmann TR
16-0289 was used in Flow cytometry/Cell sorting to collate a detailed analysis of the regulation of Amphiregulin expression by human T cell subsets.
Thu Dec 13 00:00:00 EST 2012
The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin.
PloS one
Qi Y,Operario DJ,Georas SN,Mosmann TR
16-0289 was used in Flow cytometry/Cell sorting to collate a detailed analysis of the regulation of Amphiregulin expression by human T cell subsets.
Thu Dec 13 00:00:00 EST 2012
Hydrogen sulfide is an endogenous potentiator of T cell activation.
The Journal of biological chemistry
Miller TW,Wang EA,Gould S,Stein EV,Kaur S,Lim L,Amarnath S,Fowler DH,Roberts DD
16-0289 was used in Flow cytometry/Cell sorting to study the effects of H(2)S exposure on T cell activation, and as a novel immunomodulatory molecule in T cells.
Fri Feb 03 00:00:00 EST 2012
Next-generation insights into regulatory T cells: expression profiling and FoxP3 occupancy in Human.
Nucleic acids research
Birzele F,Fauti T,Stahl H,Lenter MC,Simon E,Knebel D,Weith A,Hildebrandt T,Mennerich D
16-0289 was used in Functional assays to study the role of FoxP3 in generating transcriptional differences between primary human CD4(+) T helper and regulatory T-cells.
Sat Oct 01 00:00:00 EDT 2011
Glycogen synthase kinase-3β is a crucial mediator of signal-induced RelB degradation.
Oncogene
Neumann M,Klar S,Wilisch-Neumann A,Hollenbach E,Kavuri S,Leverkus M,Kandolf R,Brunner-Weinzierl MC,Klingel K
16-0289 was used in Functional assays to reveal that hReIB is inducibly phosphorylated by GSK-3b in vitro, identifying GSK-3b as a critical regulator of ReIB degradation and thus the NF-kB pathway.
Thu May 26 00:00:00 EDT 2011
Activation of HIV transcription by the viral Tat protein requires a demethylation step mediated by lysine-specific demethylase 1 (LSD1/KDM1).
PLoS pathogens
Sakane N,Kwon HS,Pagans S,Kaehlcke K,Mizusawa Y,Kamada M,Lassen KG,Chan J,Greene WC,Schnoelzer M,Ott M
16-0289 was used in Flow cytometry/Cell sorting to examine the interactions between monomethylation of lysine 51 and acetylation of lysine 50 within the RNA-binding domain of the HIV Tat protein.
Mon Aug 01 00:00:00 EDT 2011
CD23-bound IgE augments and dominates recall responses through human naive B cells.
Journal of immunology (Baltimore, Md. : 1950)
Griffith QK,Liang Y,Onguru DO,Mwinzi PN,Ganley-Leal LM
16-0289 was used in Functional assays to study the relationship between BCR and CD23-bound IgE-mediated B cell activation in the context of schistosomiasis, showing that CD23-bound IgE augments and dominates recall responses through naive B cells.
Sat Jan 15 00:00:00 EST 2011
Tracking immune cell proliferation and cytotoxic potential using flow cytometry.
Methods in molecular biology (Clifton, N.J.)
Tario JD,Muirhead KA,Pan D,Munson ME,Wallace PK
16-0289 was used in Functional assays to illustrate how tracking dye fluorescence profiles could be used to ascertain the precursor frequencies of different subsets in the T-cell pool.
Mon May 23 00:00:00 EDT 2011
MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1.
Journal of immunology (Baltimore, Md. : 1950)
Pan W,Zhu S,Yuan M,Cui H,Wang L,Luo X,Li J,Zhou H,Tang Y,Shen N
16-0289 was used in Functional assays to identify two miRNAs for regulating methylation in the autoimmune disease lupus through direct and indirect mechanisms, which may allow the development of future therapies.
Tue Jun 15 00:00:00 EDT 2010
Regulation of growth and survival of activated T cells by cell-transducing inhibitors of Ras.
FEBS letters
Malik NM,Gilroy DW,Kabouridis PS
16-0289 was used in Functional assays to develop cell-penetrating Ras inhibitors and to study their ability to inhibit T-cell activation, showing that anti-CD3/CD28-activated cells had a reduction in cell size, proliferation and increased apoptosis; revealing a role of Ras in survival in T cells.
Mon Jan 05 00:00:00 EST 2009
Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation.
PloS one
Brusko TM,Wasserfall CH,Hulme MA,Cabrera R,Schatz D,Atkinson MA
16-0289 was used in Functional assays to indicate that sCD25 functions as a surrogate marker of T-cell activation and an indicator of subsequent cellular death.
Tue Nov 24 00:00:00 EST 2009
miR-155 inhibition sensitizes CD4+ Th cells for TREG mediated suppression.
PloS one
Stahl HF,Fauti T,Ullrich N,Bopp T,Kubach J,Rust W,Labhart P,Alexiadis V,Becker C,Hafner M,Weith A,Lenter MC,Jonuleit H,Schmitt E,Mennerich D
16-0289 was used in Flow cytometry/Cell sorting to demonstrate a crucial role of miR-155 in nTreg cell-mediated tolerance.
Thu Sep 24 00:00:00 EDT 2009
