Invitrogen

CD4 Monoclonal Antibody (GK1.5), FITC, eBioscience™

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

97 Published Figures

415 References

View all (606) CD4 antibodies

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CD4 Antibody (11-0041-82) in Flow

Staining of mouse thymocytes with Anti-Mouse CD8a PE (Product # 12-0081-82) (left) or mouse splenocytes with Anti-Mouse CD3e PE (Product # 12-0031-82) (right) and Anti-Mouse CD4 FITC. Total viable cells were used for analysis.

CD4 Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)

Product Image Gallery

CD4 Antibody — Staining of mouse splenocytes. As expected based on known relative expression patterns, CD4 clone GK1.5 stains about 25% of total lymphocytes and does not stain CD45R (B220)+ B cells. Details: Balb/c splenocytes were surface stained with CD45R (B220, clone RA3-6B2) and Rat IgG2b Isotype Control or CD4 (clone GK1.5). Cells in the lymphocyte gate were used for analysis. {RE}

Product Details

11-0041-82

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 20 publications 20 publications

Immunohistochemistry (Paraffin) (IHC (P))

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

View 7 publications 7 publications

Flow Cytometry (Flow)

0.25 µg/test

View 380 publications 380 publications

Functional Assay (Functional)

View 2 publications 2 publications

Miscellaneous PubMed (Misc)

View 3 publications 3 publications

Product Specifications

Species Reactivity

Mouse

Published species

Fish, Human, Mouse, Rat

Host/Isotype

Rat / IgG2b, kappa

Recommended Isotype Control

Rat IgG2b kappa Isotype Control (eB149/10H5), FITC, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

GK1.5

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_464892

Product Specific Information

Description: The GK1.5 monoclonal antibody reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor expressed by a majority of thymocytes, subpopulation of mature T cells and dendritic cells. CD4 binds to MHC class II on the surface of antigen presenting cells and plays an important role both in T cell development and in optimal functioning of mature T cells. In T cells, CD4 associates with protein tyrosine kinase p56lck through its cytoplasmic tail. Binding of GK1.5 is blocked by RM4-5.

Applications Reported: The GK1.5 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This GK1.5 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes. This can be used at less than or equal to 0.25 µg per test A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

Product References

Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis.

Neural regeneration research

Liu C,Guo S,Liu R,Guo M,Wang Q,Chai Z,Xiao B,Ma C

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2024

YAP/STAT3 inhibited CD8⁺ T cells activity in the breast cancer immune microenvironment by inducing M2 polarization of tumor-associated macrophages.

Cancer medicine

Wang C,Shen N,Guo Q,Tan X,He S

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

Heterologous vaccination utilizing viral vector and protein platforms confers complete protection against SFTSV.

Scientific reports

Kim JY,Jeon K,Hong JJ,Park SI,Cho H,Park HJ,Kwak HW,Park HJ,Bang YJ,Lee YS,Bae SH,Kim SH,Hwang KA,Jung DI,Cho SH,Seo SH,Kim G,Oh H,Lee HY,Kim KH,Lim HY,Jeon P,Lee JY,Chung J,Lee SM,Ko HL,Song M,Cho NH,Lee YS,Hong SH,Nam JH

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Sat May 20 00:00:00 EDT 2023

B cell extracellular vesicles contain monomeric IgM that binds antigen and enters target cells.

iScience

Gutknecht MF,Holodick NE,Rothstein TL

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Sep 15 00:00:00 EDT 2023

Subconjunctival injection of human umbilical cord mesenchymal stem cells alleviates experimental allergic conjunctivitis via regulating T cell response.

Stem cell research & therapy

Li D,Ou Q,Shen Q,Lu MM,Xu JY,Jin C,Gao F,Wang J,Zhang J,Zhang J,Li J,Lu L,Xu GT,Tian H

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Oct 02 00:00:00 EDT 2023

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge.

Biomaterials

Sun S,Li E,Zhao G,Tang J,Zuo Q,Cai L,Xu C,Sui C,Ou Y,Liu C,Li H,Ding Y,Li C,Lu D,Zhang W,Luo P,Cheng P,Gao Y,Tu C,Pitard B,Rosenecker J,Wang B,Liu Y,Zou Q,Guan S

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2023

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge.

Biomaterials

Sun S,Li E,Zhao G,Tang J,Zuo Q,Cai L,Xu C,Sui C,Ou Y,Liu C,Li H,Ding Y,Li C,Lu D,Zhang W,Luo P,Cheng P,Gao Y,Tu C,Pitard B,Rosenecker J,Wang B,Liu Y,Zou Q,Guan S

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2023

BATF2 promotes HSC myeloid differentiation by amplifying IFN response mediators during chronic infection.

iScience

Le DT,Florez MA,Kus P,Tran BT,Kain B,Zhu Y,Christensen K,Jain A,Malovannaya A,King KY

11-0041-82 was used in Flow cytometry/Cell sorting to elucidate potential therapeutic strategies to boost immunity while preserving HSC function during chronic infection.

Fri Feb 17 00:00:00 EST 2023

HSF1 promotes CD69⁺ Treg differentiation to inhibit colitis progression.

Theranostics

Yu L,Zhou B,Zhu Y,Li L,Zhong Y,Zhu L,Wang H,Chen H,Xu J,Guo T,Feng L,Wang X,Cai Z,Wang J,Jin H

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Apr 18 00:00:00 EDT 2023

Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-like Autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Hodgson R,Crockford TL,Bhandari A,Kepple JD,Back J,Cawthorne E,Abeler-Dörner L,Laing AG,Clare S,Speak A,Adams DJ,Dougan G,Hayday AC,Deobagkar-Lele M,Cornall RJ,Bull KR

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Dexmedetomidine alleviates acute lung injury by promoting Tregs differentiation via activation of AMPK/SIRT1 pathway.

Inflammopharmacology

Zhang ZT,Xie K,Luo RJ,Zhang DY,He ZW,Li KF,Lin SH,Xu F

11-0041-82 was used in Flow cytometry/Cell sorting to explore the anti-inflammatory effect and the potential mechanism of dexmedetomidine in ARDS/ALI.

Wed Feb 01 00:00:00 EST 2023

Molecular Imaging of Oxygenation Changes during Immunotherapy in Combination with Paclitaxel in Triple Negative Breast Cancer.

Biomedicines

Napier TS,Lynch SE,Lu Y,Song PN,Burns AC,Sorace AG

11-0041-82 was used in Flow cytometry/Cell sorting to provide insights into how PEF protein dynamics affect secretion of important physiological cargoes such as collagen I and significantly impact ER stress.

Wed Jan 04 00:00:00 EST 2023

Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting.

Frontiers in immunology

Clubb JHA,Kudling TV,Girych M,Haybout L,Pakola S,Hamdan F,Cervera-Carrascon V,Hemmes A,Grönberg-Vähä-Koskela S,Santos JM,Quixabeira DCA,Basnet S,Heiniö C,Arias V,Jirovec E,Kaptan S,Havunen R,Sorsa S,Erikat A,Schwartz J,Anttila M,Aro K,Viitala T,Vattulainen I,Cerullo V,Kanerva A,Hemminki A

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Feb 27 00:00:00 EST 2023

GH18 family glycoside hydrolase Chitinase A of Salmonella enhances virulence by facilitating invasion and modulating host immune responses.

PLoS pathogens

Chandra K,Roy Chowdhury A,Chatterjee R,Chakravortty D

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Apr 01 00:00:00 EDT 2022

Hydroxychloroquine induces apoptosis of myeloid-derived suppressor cells via up-regulation of CD81 contributing to alleviate lupus symptoms.

Molecular medicine (Cambridge, Mass.)

Ni J,Zhu H,Lu L,Zhao Z,Jiang J,You X,Wang Y,Ma Y,Yang Z,Hou Y,Dou H

11-0041-82 was used in Flow cytometry/Cell sorting to support that HCQ promoted the apoptosis of MDSCs by up-regulating the expression level of CD81 in MDSCs, and ultimately alleviated lupus symptoms. Our results may assist scholars to develop further effective therapies for SLE.

Wed Jun 15 00:00:00 EDT 2022

Abdominopelvic FLASH Irradiation Improves PD-1 Immune Checkpoint Inhibition in Preclinical Models of Ovarian Cancer.

Molecular cancer therapeutics

Eggold JT,Chow S,Melemenidis S,Wang J,Natarajan S,Loo PE,Manjappa R,Viswanathan V,Kidd EA,Engleman E,Dorigo O,Loo BW,Rankin EB

11-0041-82 was used in Flow cytometry/Cell sorting to highlight the potential for FLASH irradiation to improve the therapeutic efficacy of checkpoint inhibition in the treatment of ovarian cancer.

Tue Feb 01 00:00:00 EST 2022

Rotenone aggravates PD-like pathology in A53T mutant human α-synuclein transgenic mice in an age-dependent manner.

Frontiers in aging neuroscience

Chen AD,Cao JX,Chen HC,Du HL,Xi XX,Sun J,Yin J,Jing YH,Gao LP

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Aug 26 00:00:00 EDT 2022

IL-33 Deficiency Attenuates Lung Inflammation by Inducing Th17 Response and Impacting the Th17/Treg Balance in LPS-Induced ARDS Mice via Dendritic Cells.

Journal of immunology research

Cheng L,Jiao Y,Jiang W,Zhang X,Zhang L,Jia G

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Dec 27 00:00:00 EST 2022

Interferon-γ Stimulates Interleukin-27 Derived from Dendritic Cells to Regulate Th9 Differentiation through STAT1/3 Pathway.

Disease markers

Xiong P,Liu T,Chen Y,Xu Q,Hu X,Han F,Shi L

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Oct 31 00:00:00 EDT 2022

CD4⁺ CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.

Aging and disease

Shen S,Li Y,Jin M,Fan D,Pan R,Lin A,Chen Y,Xiang L,Zhao RC,Shao J

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2022

Free Fatty Acid Receptor 4 (FFA4) Activation Ameliorates Imiquimod-Induced Psoriasis in Mice.

International journal of molecular sciences

Son SE,Koh JM,Im DS

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Apr 19 00:00:00 EDT 2022

Free Fatty Acid Receptor 4 (FFA4) Activation Ameliorates Imiquimod-Induced Psoriasis in Mice.

International journal of molecular sciences

Son SE,Koh JM,Im DS

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Apr 19 00:00:00 EDT 2022

Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage.

Cell death & disease

Del Rio Oliva M,Basler M

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2022

Withdrawn: Parecoxib inhibits inflammatory responses in a mouse model of sepsis.

FEBS open bio

No authors listed

11-0041 was used in Flow cytometry/Cell sorting to suggest that Parecoxib inhibits the inflammatory response and has protective effects against sepsis in mice, and may have potential as a novel therapeutic method for treating sepsis.

Sat Jan 01 00:00:00 EST 2022

Maternal-fetal conflict averted by progesterone- induced FOXP3+ regulatory T cells.

iScience

Severance AL,Kinder JM,Xin L,Burg AR,Shao TY,Pham G,Tilburgs T,Goodman WA,Mesiano S,Way SS

11-0041-82 was used in Flow cytometry/Cell sorting to show that the female reproductive hormone, progesterone, coordinates immune tolerance by stimulating expansion of FOXP3+ regulatory T cells.

Fri Jun 17 00:00:00 EDT 2022

Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression.

Nature communications

Qi M,Xia Y,Wu Y,Zhang Z,Wang X,Lu L,Dai C,Song Y,Xu K,Ji W,Zhan L

11-0041-82 was used in Flow Cytometry to demonstrate that Lin28B promotes lung metastasis of breast cancer by building an immune-suppressive pre-metastatic niche.

Wed Feb 16 00:00:00 EST 2022

Lentinan alleviates arsenic-induced hepatotoxicity in mice via downregulation of OX40/IL-17A and activation of Nrf2 signaling.

BMC pharmacology & toxicology

Yang Y,Song S,Nie Y,Chen R,Chen P

11-0041-82 was used in Flow Cytometry to demonstrate that lentinan antagonizes SA-induced hepatotoxicity in mice, may be involved in the downregulations of pro-inflammatory OX40 or IL-17A and the activation of anti-oxidative Nrf2, NQO1 signals.

Tue Mar 22 00:00:00 EDT 2022

Growth arrest-specific protein 2 (GAS2) interacts with CXCR4 to promote T-cell leukemogenesis partially via c-MYC.

Molecular oncology

Ma W,Wan Y,Zhang J,Yao J,Wang Y,Lu J,Liu H,Huang X,Zhang X,Zhou H,He Y,Wu D,Wang J,Zhao Y

11-0041-82 was used in Flow cytometry/Cell sorting to suggest that targeting the GAS2/CXCR4 axis is a potential therapeutic strategy for T-ALL.

Sat Oct 01 00:00:00 EDT 2022

Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy.

Science advances

Poh AR,Love CG,Chisanga D,Steer JH,Baloyan D,Chopin M,Nutt S,Rautela J,Huntington ND,Etemadi N,O'Brien M,O'Keefe R,Ellies LG,Macri C,Mintern JD,Whitehead L,Gangadhara G,Boon L,Chand AL,Lowell CA,Shi W,Pixley FJ,Ernst M

11-0041-82 was used in Flow cytometry/Cell sorting to suggest that therapeutic targeting of HCK activity enhances response to immunotherapy by simultaneously stimulating immune cell activation and inhibiting the immunosuppressive tumor microenvironment.

Fri Jun 24 00:00:00 EDT 2022

Structural and Functional Changes in Aged Skin Lymphatic Vessels.

Frontiers in aging

Kataru RP,Park HJ,Shin J,Baik JE,Sarker A,Brown S,Mehrara BJ

11-0041-82 was used in Flow cytometry/Cell sorting to quantitatively analyze the effects of aging on skin initial and collecting lymphatic vessels, dendritic cell migration, cutaneous lymphatic pumping, and VEGFR-3 signaling in lymphatic endothelial cells (LECs).

Fri Aug 25 00:00:00 EDT 2023

Btla signaling in conventional and regulatory lymphocytes coordinately tempers humoral immunity in the intestinal mucosa.

Cell reports

Stienne C,Virgen-Slane R,Elmén L,Veny M,Huang S,Nguyen J,Chappell E,Balmert MO,Shui JW,Hurchla MA,Kronenberg M,Peterson SN,Murphy KM,Ware CF,Šedý JR

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunohistochemistry

Tue Mar 22 00:00:00 EDT 2022

Protective Effect of Poria Cocos Polysaccharides on Fecal Peritonitis-Induced Sepsis in Mice Through Inhibition of Oxidative Stress, Inflammation, Apoptosis, and Reduction of Treg Cells.

Frontiers in microbiology

Wu Y,Li D,Wang H,Wan X

11-0041-82 was used in Flow cytometry/Cell sorting to show that PCPs have pharmacological and biological effects on FP-induced septic mice, and its molecular mechanism is related to antioxidative, anti-inflammation, anti-apoptosis, and the reduction of Treg activity in splenic cells.

Sat Jul 16 00:00:00 EDT 2022

MIF confers survival advantage to pancreatic CAFs by suppressing interferon pathway-induced p53-dependent apoptosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Suresh V,Dash P,Suklabaidya S,Murmu KC,Sasmal PK,Jogdand GM,Parida D,Sethi M,Das B,Mohapatra D,Saha S,Prasad P,Satoskar A,Senapati S

11-0041-82 was used in Flow Cytometry to report that the PSCs of mouse or cancer-associated fibroblast cells (CAFs) of human expresses MIF and its receptors, whose expression gets upregulated upon LPS or TNF-α stimulation.

Mon Aug 01 00:00:00 EDT 2022

Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.

Immunity

Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury in a non-human primate model of COVID-19.

Nature nanotechnology

Li Z,Wang Z,Dinh PC,Zhu D,Popowski KD,Lutz H,Hu S,Lewis MG,Cook A,Andersen H,Greenhouse J,Pessaint L,Lobo LJ,Cheng K

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunocytochemistry

Sun Aug 01 00:00:00 EDT 2021

NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.

Nature immunology

Gu M,Zhou X,Sohn JH,Zhu L,Jie Z,Yang JY,Zheng X,Xie X,Yang J,Shi Y,Brightbill HD,Kim JB,Wang J,Cheng X,Sun SC

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase.

International journal of oral science

Zhao X,Liu J,Zhang C,Yu N,Lu Z,Zhang S,Li Y,Li Q,Liu J,Liu D,Pan Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.

The Journal of experimental medicine

Sasai M,Ma JS,Okamoto M,Nishino K,Nagaoka H,Takashima E,Pradipta A,Lee Y,Kosako H,Suh PG,Yamamoto M

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Jul 05 00:00:00 EDT 2021

High Ambient Temperature Aggravates Experimental Autoimmune Uveitis Symptoms.

Frontiers in cell and developmental biology

Pan S,Tan H,Chang R,Wang Q,Zhu Y,Chen L,Li H,Su G,Zhou C,Cao Q,Kijlstra A,Yang P

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Apr 13 00:00:00 EDT 2021

High Ambient Temperature Aggravates Experimental Autoimmune Uveitis Symptoms.

Frontiers in cell and developmental biology

Pan S,Tan H,Chang R,Wang Q,Zhu Y,Chen L,Li H,Su G,Zhou C,Cao Q,Kijlstra A,Yang P

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Apr 13 00:00:00 EDT 2021

Dynamic changes in the systemic immune responses of spinal cord injury model mice.

Neural regeneration research

Gao TY,Huang FF,Xie YY,Wang WQ,Wang LD,Mu D,Cui Y,Wang B

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Dynamic changes in the systemic immune responses of spinal cord injury model mice.

Neural regeneration research

Gao TY,Huang FF,Xie YY,Wang WQ,Wang LD,Mu D,Cui Y,Wang B

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

VX-765 reduces neuroinflammation after spinal cord injury in mice.

Neural regeneration research

Chen J,Chen YQ,Shi YJ,Ding SQ,Shen L,Wang R,Wang QY,Zha C,Ding H,Hu JG,Lü HZ

11-0041-82 was used in Flow Cytometry to suggest that VX-765 can reduce neuroinflammation and improve nerve function recovery after spinal cord injury by inhibiting caspase-1/interleukin-1β/interleukin-18.

Wed Sep 01 00:00:00 EDT 2021

Generation of a Novel Oncolytic Vaccinia Virus Using the IHD-W Strain.

Human gene therapy

Shin J,Hong SO,Kim M,Lee H,Choi H,Kim J,Hong J,Kang H,Lee E,Lee S,Kong B,Kim M,Choi H,Kim S

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

CXCR3 alleviates renal ischemia‑reperfusion injury via increase of Tregs.

Molecular medicine reports

Xian W,Wu J,Li Q,Du X,Wang N,Chen D,Gao W,Cao J

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Jul 01 00:00:00 EDT 2021

CXCR3 alleviates renal ischemia‑reperfusion injury via increase of Tregs.

Molecular medicine reports

Xian W,Wu J,Li Q,Du X,Wang N,Chen D,Gao W,Cao J

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Jul 01 00:00:00 EDT 2021

Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.

Oncology letters

Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Preliminary analysis of immunoregulatory mechanism of hyperhomocysteinemia-induced brain injury in Wistar-Kyoto rats.

Experimental and therapeutic medicine

Zhang Y,Wang L,Li X,Geng J

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Exposure to Low to Moderate Doses of Ionizing Radiation Induces A Reduction of Pro-Inflammatory Ly6chigh Monocytes and a U-Curved Response of T Cells in APOE -/- Mice.

Dose-response : a publication of International Hormesis Society

Rey N,Ebrahimian T,Gloaguen C,Kereselidze D,Magneron V,Bontemps CA,Demarquay C,Olsson G,Haghdoost S,Lehoux S,Ebrahimian TG

11-0041-82 was used in Flow Cytometry to investigate the immunomodulatory response of different doses and dose-rates of irradiation in ApoE-/- mice.

Fri Jun 25 00:00:00 EDT 2021

Estrogen receptor beta signaling in CD8⁺ T cells boosts T cell receptor activation and antitumor immunity through a phosphotyrosine switch.

Journal for immunotherapy of cancer

Yuan B,Clark CA,Wu B,Yang J,Drerup JM,Li T,Jin VX,Hu Y,Curiel TJ,Li R

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2021

Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy.

Frontiers in immunology

Agalave NM,Mody PH,Szabo-Pardi TA,Jeong HS,Burton MD

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Sep 20 00:00:00 EDT 2021

Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model.

Vaccines

Trofimova O,Korotkaja K,Skrastina D,Jansons J,Spunde K,Isaguliants M,Zajakina A

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Oct 27 00:00:00 EDT 2021

A lymph node-targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2.

Science advances

Steinbuck MP,Seenappa LM,Jakubowski A,McNeil LK,Haqq CM,DeMuth PC

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation.

Frontiers in immunology

Amobi-McCloud A,Muthuswamy R,Battaglia S,Yu H,Liu T,Wang J,Putluri V,Singh PK,Qian F,Huang RY,Putluri N,Tsuji T,Lugade AA,Liu S,Odunsi K

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Oct 29 00:00:00 EDT 2021

Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells.

Stem cell research & therapy

Liu W,Zhou N,Liu Y,Zhang W,Li X,Wang Y,Zheng R,Zhang Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Feb 26 00:00:00 EST 2021

G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence.

Cell death & disease

Sun SN,Ni SH,Li Y,Liu X,Deng JP,Chen ZX,Li H,Feng WJ,Huang YS,Li DN,Xian SX,Yang ZQ,Wang LJ,Lu L

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Jun 08 00:00:00 EDT 2021

Butyrate Improves Skin/Lung Fibrosis and Intestinal Dysbiosis in Bleomycin-Induced Mouse Models.

International journal of molecular sciences

Park HJ,Jeong OY,Chun SH,Cheon YH,Kim M,Kim S,Lee SI

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Mar 09 00:00:00 EST 2021

Mapping Rora expression in resting and activated CD4+ T cells.

PloS one

Haim-Vilmovsky L,Henriksson J,Walker JA,Miao Z,Natan E,Kar G,Clare S,Barlow JL,Charidemou E,Mamanova L,Chen X,Proserpio V,Pramanik J,Woodhouse S,Protasio AV,Efremova M,Griffin JL,Berriman M,Dougan G,Fisher J,Marioni JC,McKenzie ANJ,Teichmann SA

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Nov 12 00:00:00 EST 2021

Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid.

The Journal of biological chemistry

Zhao Y,Cheng R,Zhao Y,Ge W,Yang Y,Ding Z,Xu X,Wang Z,Wu Z,Zhang J

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Oct 01 00:00:00 EDT 2021

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.

Cancers

Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Oct 07 00:00:00 EDT 2021

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.

Cancers

Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Oct 07 00:00:00 EDT 2021

A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.

Nature communications

Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.

Nature communications

Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Sang W,Xie L,Wang G,Li J,Zhang Z,Li B,Guo S,Deng CX,Dai Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Sang W,Xie L,Wang G,Li J,Zhang Z,Li B,Guo S,Deng CX,Dai Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Systemic Delivery of Oncolytic Adenovirus to Tumors Using Tumor-Infiltrating Lymphocytes as Carriers.

Cells

Santos J,Heiniö C,Quixabeira D,Zafar S,Clubb J,Pakola S,Cervera-Carrascon V,Havunen R,Kanerva A,Hemminki A

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Apr 22 00:00:00 EDT 2021

Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.

Theranostics

Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Jan 28 00:00:00 EST 2022

Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.

Theranostics

Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Jan 28 00:00:00 EST 2022

Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair.

Frontiers in immunology

Ramavath NN,Gadipudi LL,Provera A,Gigliotti LC,Boggio E,Bozzola C,Albano E,Dianzani U,Sutti S

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Feb 14 00:00:00 EST 2022

Remote Limb Ischemic Postconditioning Protects Against Ischemic Stroke by Promoting Regulatory T Cells Thriving.

Journal of the American Heart Association

Yu HH,Ma XT,Ma X,Chen M,Chu YH,Wu LJ,Wang W,Qin C,Tian DS

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Nov 16 00:00:00 EST 2021

Remote Limb Ischemic Postconditioning Protects Against Ischemic Stroke by Promoting Regulatory T Cells Thriving.

Journal of the American Heart Association

Yu HH,Ma XT,Ma X,Chen M,Chu YH,Wu LJ,Wang W,Qin C,Tian DS

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Nov 16 00:00:00 EST 2021

TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells.

JCI insight

de Mattos Barbosa MG,Lefferts AR,Huynh D,Liu H,Zhang Y,Fu B,Barnes J,Samaniego M,Bram RJ,Geha RS,Shikanov A,Prak ETL,Farkash EA,Platt JL,Cascalho M

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunohistochemistry

Wed Sep 08 00:00:00 EDT 2021

Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.

International journal of molecular sciences

Sato S,Shimizu E,He J,Ogawa M,Asai K,Yazu H,Rusch R,Yamane M,Yang F,Fukuda S,Kawakami Y,Tsubota K,Ogawa Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunocytochemistry

Sat Apr 03 00:00:00 EDT 2021

Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.

International journal of molecular sciences

Sato S,Shimizu E,He J,Ogawa M,Asai K,Yazu H,Rusch R,Yamane M,Yang F,Fukuda S,Kawakami Y,Tsubota K,Ogawa Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunocytochemistry

Sat Apr 03 00:00:00 EDT 2021

Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression.

Clinical and translational medicine

Cheng CS,Tan HY,Wang N,Chen L,Meng Z,Chen Z,Feng Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunohistochemistry

Tue Jun 01 00:00:00 EDT 2021

G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.

Nature communications

Gurusamy M,Tischner D,Shao J,Klatt S,Zukunft S,Bonnavion R,Günther S,Siebenbrodt K,Kestner RI,Kuhlmann T,Fleming I,Offermanns S,Wettschureck N

11-0041-82 was used in Flow cytometry/Cell sorting to show that in mice lacking P2Y10 in the CD4 T cell compartment, the severity of experimental autoimmune encephalomyelitis and cutaneous contact hypersensitivity is reduced.

Tue Nov 23 00:00:00 EST 2021

Investigating the Mechanism of Trimethoprim-Induced Skin Rash and Liver Injury.

Toxicological sciences : an official journal of the Society of Toxicology

Cao Y,Bairam A,Jee A,Liu M,Uetrecht J

11-0041-82 was used in Flow cytometry/Cell sorting to provide important data required to understand the mechanism of TMP-induced skin rash and drug-induced skin rash in general.

Fri Feb 26 00:00:00 EST 2021

Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.

Frontiers in immunology

Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Jul 05 00:00:00 EDT 2021

Intravesical High Dose BCG Tokyo and Low Dose BCG Tokyo with GMCSF+IFN α Induce Systemic Immunity in a Murine Orthotopic Bladder Cancer Model.

Biomedicines

Tham SM,Rahmat JN,Chiong E,Wu Q,Esuvaranathan K,Mahendran R

11-0041-82 was used in Flow cytometry/Cell sorting to evaluate a short therapy schedule for bladder cancer using BCG Tokyo. BCG Tokyo was evaluated in vitro using bone marrow derived dendritic cells, neutrophils, RAW macrophages and the murine bladder cancer cell line, MB49PSA, and compared to other BCG strains.

Thu Nov 25 00:00:00 EST 2021

Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response.

Cell reports

Vaena S,Chakraborty P,Lee HG,Janneh AH,Kassir MF,Beeson G,Hedley Z,Yalcinkaya A,Sofi MH,Li H,Husby ML,Stahelin RV,Yu XZ,Mehrotra S,Ogretmen B

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunocytochemistry

Tue May 04 00:00:00 EDT 2021

Myocardial infarction accelerates breast cancer via innate immune reprogramming.

Nature medicine

Koelwyn GJ,Newman AAC,Afonso MS,van Solingen C,Corr EM,Brown EJ,Albers KB,Yamaguchi N,Narke D,Schlegel M,Sharma M,Shanley LC,Barrett TJ,Rahman K,Mezzano V,Fisher EA,Park DS,Newman JD,Quail DF,Nelson ER,Caan BJ,Jones LW,Moore KJ

11-0041 was used in Flow cytometry/Cell sorting to show that myocardial infarction (MI) accelerates breast cancer outgrowth and cancer-specific mortality in mice and humans. I.

Tue Sep 01 00:00:00 EDT 2020

The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.

Cell

Kitamoto S,Nagao-Kitamoto H,Jiao Y,Gillilland MG,Hayashi A,Imai J,Sugihara K,Miyoshi M,Brazil JC,Kuffa P,Hill BD,Rizvi SM,Wen F,Bishu S,Inohara N,Eaton KA,Nusrat A,Lei YL,Giannobile WV,Kamada N

11-0041-82 was used in Flow Cytometry to conclude that oral inflammation, such as periodontitis, exacerbates gut inflammation by supplying the gut with both colitogenic pathobionts and pathogenic T cells.

Thu Jul 23 00:00:00 EDT 2020

Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.

Immunity

Bonavita E,Bromley CP,Jonsson G,Pelly VS,Sahoo S,Walwyn-Brown K,Mensurado S,Moeini A,Flanagan E,Bell CR,Chiang SC,Chikkanna-Gowda CP,Rogers N,Silva-Santos B,Jaillon S,Mantovani A,Reis e Sousa C,Guerra N,Davis DM,Zelenay S

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Dec 15 00:00:00 EST 2020

Immuno-moodulin: A new anxiogenic factor produced by Annexin-A1 transgenic autoimmune-prone T cells.

Brain, behavior, and immunity

Piras G,Rattazzi L,Paschalidis N,Oggero S,Berti G,Ono M,Bellia F,D'Addario C,Dell'Osso B,Pariante CM,Perretti M,D'Acquisto F

11-0041-82 was used in Flow Cytometry to identify a novel factor, a small protein of approximately 21 kDa encoded by the gene 2610019F03Rik, thus named Immuno-moodulin, associated with overexpressing Annexin-A1 exclusively in T cells, as a novel peripheral determinant that modulates anxiety behavior.

Wed Jul 01 00:00:00 EDT 2020

Splenic Capture and In Vivo Intracellular Biodegradation of Biological-Grade Graphene Oxide Sheets.

ACS nano

Newman L,Jasim DA,Prestat E,Lozano N,de Lazaro I,Nam Y,Assas BM,Pennock J,Haigh SJ,Bussy C,Kostarelos K

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Aug 25 00:00:00 EDT 2020

Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.

The Journal of experimental medicine

Kang YA,Pietras EM,Passegué E

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Mar 02 00:00:00 EST 2020

Critical role of OX40 in drug-induced acute liver injury.

British journal of pharmacology

Zhang C,Jin H,Wang Y,Li C,Zhao X,Li Y,Shi W,Tian Y,Xu H,Tian D,Liu K,Jia J,Sun G,Zhang D

11-0041-82 was used in Flow Cytometry to show that OX40 is a key molecule that promotes both pro-inflammatory macrophage and CD4+ T-cell function, exacerbating paracetamol-induced liver injury.

Wed Jul 01 00:00:00 EDT 2020

Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells.

PLoS pathogens

Akhtar MN,Mishra M,Yadav V,Yadav M,Gujar R,Lal S,Kumar R,Khatri N,Sen P

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Free fatty acid receptor 4 (FFA4) activation ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis by increasing regulatory T cells in mice.

Acta pharmacologica Sinica

Son SE,Park SJ,Koh JM,Im DS

11-0041 was used in Flow cytometry/Cell sorting to show the activation of FFA4 ameliorates atopic dermatitis.

Thu Oct 01 00:00:00 EDT 2020

Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.

Journal of cellular and molecular medicine

Wu R,Liu C,Deng X,Chen L,Hao S,Ma L

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma.

Journal of cellular and molecular medicine

Song Y,Wang Z,Jiang J,Piao Y,Li L,Xu C,Piao H,Li L,Yan G

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma.

Journal of cellular and molecular medicine

Song Y,Wang Z,Jiang J,Piao Y,Li L,Xu C,Piao H,Li L,Yan G

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.

Journal of Cancer

Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Effects of combined treatment with PD‑L1 Ig and CD40L mAb on immune tolerance in the CBA/J x DBA/2 mouse model.

Molecular medicine reports

Li G,Yang L,Li D,Zhang J,Du L,Xia L,Liu Y,Hu W

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

IDO inhibitor synergized with radiotherapy to delay tumor growth by reversing T cell exhaustion.

Molecular medicine reports

Liu M,Li Z,Yao W,Zeng X,Wang L,Cheng J,Ma B,Zhang R,Min W,Wang H

11-0041-82 was used in Flow Cytometry to investigate whether an iindoleamine 2,3‚dioxygenase (IDO) inhibitor synergized with radiotherapy (RT) can further inhibit tumor growth.

Wed Jan 01 00:00:00 EST 2020

FUT1 deficiency elicits immune dysregulation and corneal opacity in steady state and under stress.

Cell death & disease

Kim KW,Ryu JS,Ko JH,Kim JY,Kim HJ,Lee HJ,Oh JH,Chung JH,Oh JY

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Apr 24 00:00:00 EDT 2020

Elevated granulocytic myeloid-derived suppressor cells are closely related with elevation of Th17 cells in mice with experimental asthma.

International journal of biological sciences

Xue F,Yu M,Li L,Zhang W,Ma Y,Dong L,Shan W,Zheng Y,Wang T,Feng D,Lv J,Wang X

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Nov 12 00:00:00 EST 2021

Elevated granulocytic myeloid-derived suppressor cells are closely related with elevation of Th17 cells in mice with experimental asthma.

International journal of biological sciences

Xue F,Yu M,Li L,Zhang W,Ma Y,Dong L,Shan W,Zheng Y,Wang T,Feng D,Lv J,Wang X

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Nov 12 00:00:00 EST 2021

Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.

International journal of molecular sciences

Yoon CH,Ryu JS,Hwang HS,Kim MK

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Jun 11 00:00:00 EDT 2020

Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma.

Cells

Martinikova AS,Burocziova M,Stoyanov M,Macurek L

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Sep 10 00:00:00 EDT 2020

Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma.

Cells

Martinikova AS,Burocziova M,Stoyanov M,Macurek L

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Sep 10 00:00:00 EDT 2020

Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.

JCI insight

Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Aug 20 00:00:00 EDT 2020

Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.

Communications biology

Waaler J,Mygland L,Tveita A,Strand MF,Solberg NT,Olsen PA,Aizenshtadt A,Fauskanger M,Lund K,Brinch SA,Lycke M,Dybing E,Nygaard V,Bøe SL,Heintz KM,Hovig E,Hammarström C,Corthay A,Krauss S

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Apr 24 00:00:00 EDT 2020

CRID3, a blocker of apoptosis associated speck like protein containing a card, ameliorates murine spinal cord injury by improving local immune microenvironment.

Journal of neuroinflammation

Chen YQ,Wang SN,Shi YJ,Chen J,Ding SQ,Tang J,Shen L,Wang R,Ding H,Hu JG,Lü HZ

11-0041 was used in Flow cytometry/Cell sorting to study the effect of CRID3 on the local microenvironment and the possible role in neuroprotection following spinal cord injury.

Sat Aug 29 00:00:00 EDT 2020

Critical role of WNK1 in MYC-dependent early mouse thymocyte development.

eLife

Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL

11-0041 was used in Flow cytometry/Cell sorting to ind that WNK1 is required for the transition of double negative (DN) thymocytes through the β-selection checkpoint and subsequent proliferation and differentiation into double positive (DP) thymocytes.

Wed Oct 14 00:00:00 EDT 2020

BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages.

eLife

Li J,Zhang L,Zheng Y,Shao R,Liang Q,Yu W,Wang H,Zou W,Wang D,Xiang J,Lin A

11-0041-82 was used in Flow Cytometry to put forward a model in which inactivation of BAD confers the apoptosis resistance on synovial sublining macrophages, thereby contributing to the development of arthritis, suggesting that BAD may be a potential therapeutic target for RA.

Thu Dec 03 00:00:00 EST 2020

CD8⁺ T Cell Functional Exhaustion Overrides Pregnancy-Induced Fetal Antigen Alloimmunization.

Cell reports

Kinder JM,Turner LH,Stelzer IA,Miller-Handley H,Burg A,Shao TY,Pham G,Way SS

11-0041-82 was used in Flow Cytometry to demonstrate distinct mechanisms whereby fetal tolerance is maintained during primary compared with subsequent pregnancies.

Tue Jun 23 00:00:00 EDT 2020

The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function.

International journal of molecular sciences

Subbannayya Y,Haug M,Pinto SM,Mohanty V,Meås HZ,Flo TH,Prasad TSK,Kandasamy RK

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Dec 29 00:00:00 EST 2020

MicroRNA-200a induces immunosuppression by promoting PTEN-mediated PD-L1 upregulation in osteosarcoma.

Aging

Liu Z,Wen J,Wu C,Hu C,Wang J,Bao Q,Wang H,Wang J,Zhou Q,Wei L,Shen Y,Zhang W

11-0041 was used in Flow cytometry/Cell sorting to provide important and novel insight into a regulatory axis involving microRNA-200a/PTEN/ PD-L1 axis, which determines osteosarcoma growth and the efficacy of PD-L1-targeted immunotherapy.

Fri Jan 24 00:00:00 EST 2020

ABCA1 Exerts Tumor-Suppressor Function in Myeloproliferative Neoplasms.

Cell reports

Viaud M,Abdel-Wahab O,Gall J,Ivanov S,Guinamard R,Sore S,Merlin J,Ayrault M,Guilbaud E,Jacquel A,Auberger P,Wang N,Levine RL,Tall AR,Yvan-Charvet L

11-0041 was used in Flow cytometry/Cell sorting to identify somatic mutations in ABCA1 that subvert its anti-proliferative and cholesterol efflux functions and permit the progression of myeloid neoplasms.

Tue Mar 10 00:00:00 EDT 2020

ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.

PloS one

Hanson A,Elpek K,Duong E,Shallberg L,Fan M,Johnson C,Wallace M,Mabry GR,Sazinsky S,Pepper L,Shu CJ,Sathyanarayanan S,Zuerndorfer S,Simpson T,Gostissa M,Briskin M,Law D,Michaelson J,Harvey CJ

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Nov 16 00:00:00 EST 2020

Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.

Scientific reports

Kedzierska AE,Lorek D,Slawek A,Chelmonska-Soyta A

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Jun 29 00:00:00 EDT 2020

Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.

Frontiers in immunology

Yu Y,Wu DM,Li J,Deng SH,Liu T,Zhang T,He M,Zhao YY,Xu Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Jun 21 00:00:00 EDT 2021

Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.

Frontiers in immunology

Yu Y,Wu DM,Li J,Deng SH,Liu T,Zhang T,He M,Zhao YY,Xu Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Jun 21 00:00:00 EDT 2021

Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.

Nature

Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Jul 01 00:00:00 EDT 2019

A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation.

Immunity

Minutti CM,Modak RV,Macdonald F,Li F,Smyth DJ,Dorward DA,Blair N,Husovsky C,Muir A,Giampazolias E,Dobie R,Maizels RM,Kendall TJ,Griggs DW,Kopf M,Henderson NC,Zaiss DM

11-0041-82 was used in Flow Cytometry to identify macrophages as a critical source of Amphiregulin, revealing a direct effector mechanism by which these cells contribute to tissue restoration after acute injury.

Tue Mar 19 00:00:00 EDT 2019

Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer.

The Journal of clinical investigation

Soukup AA,Zheng Y,Mehta C,Wu J,Liu P,Cao M,Hofmann I,Zhou Y,Zhang J,Johnson KD,Choi K,Keles S,Bresnick EH

11-0041 was used in Flow cytometry/Cell sorting to study the mechanisms underlying how GATA2 enhancer disease mutations impact hematopoiesis and pathology.

Fri Mar 01 00:00:00 EST 2019

T helper 2 differentiation is necessary for development of lymphedema.

Translational research : the journal of laboratory and clinical medicine

Ly CL,Nores GDG,Kataru RP,Mehrara BJ

11-0041 was used in Flow cytometry/Cell sorting to analyse the effect of lymphatic injury in transgenic mice with mutations that cause defects in Th1 and Th2 cell generation (T-bet knockout or T-betKO and STAT6 knockout or STAT6KO mice, respectively).

Mon Apr 01 00:00:00 EDT 2019

Epigenetically modulated FOXM1 suppresses dendritic cell maturation in pancreatic cancer and colon cancer.

Molecular oncology

Zhou Z,Chen H,Xie R,Wang H,Li S,Xu Q,Xu N,Cheng Q,Qian Y,Huang R,Shao Z,Xiang M

11-0041 was used in Flow cytometry/Cell sorting to show that upregulation of FOXM1 by H3K79me2 in pancreatic cancer and colon cancer significantly inhibits maturation phenotypes and function of bone marrow dendritic cells (BMDCs) through the Wnt5a signaling pathway, and thus provide novel insights into FOXM1-based antitumor immunotherapy.

Mon Apr 01 00:00:00 EDT 2019

Total Glycosides of Peony Protects Against Inflammatory Bowel Disease by Regulating IL-23/IL-17 Axis and Th17/Treg Balance.

The American journal of Chinese medicine

Li Q,Shan Q,Sang X,Zhu R,Chen X,Cao G

11-0041 was used in Flow cytometry/Cell sorting to investigate the effects of total glycoside of peony on experimental colitis mice.

Fri Mar 15 00:00:00 EDT 2019

Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.

Laboratory investigation; a journal of technical methods and pathology

Hensel JA,Khattar V,Ashton R,Ponnazhagan S

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2019

Cyclooxygenase-1 Regulates the Development of Follicular Th Cells via Prostaglandin E₂.

Journal of immunology (Baltimore, Md. : 1950)

Liu T,Yang Q,Cao YJ,Yuan WM,Lei AH,Zhou P,Zhou W,Liu YD,Shi MH,Yang Q,Tang JY,Wang HK,Zhang H,Yu Y,Zhou J

11-0041-82 was used in Flow Cytometry to indicate that COX-1 plays an important role in the development of TFH cells.

Thu Aug 15 00:00:00 EDT 2019

Bryostatin-1 ameliorated experimental colitis in Il-10^-/- Mice by protecting the intestinal barrier and limiting immune dysfunction.

Journal of cellular and molecular medicine

Zuo L,Li J,Ge S,Ge Y,Shen M,Wang Y,Zhou C,Wu R,Hu J

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Aug 01 00:00:00 EDT 2019

Bryostatin-1 ameliorated experimental colitis in Il-10^-/- Mice by protecting the intestinal barrier and limiting immune dysfunction.

Journal of cellular and molecular medicine

Zuo L,Li J,Ge S,Ge Y,Shen M,Wang Y,Zhou C,Wu R,Hu J

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Aug 01 00:00:00 EDT 2019

Lactobacillus rhamnosus GG attenuates tenofovir disoproxil fumarate-induced bone loss in male mice via gut-microbiota-dependent anti-inflammation.

Therapeutic advances in chronic disease

Liu H,Gu R,Li W,Zhou W,Cong Z,Xue J,Liu Y,Wei Q,Zhou Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Sat Apr 09 00:00:00 EDT 2022

Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway.

Mediators of inflammation

Xu Y,Tang X,Yang M,Zhang S,Li S,Chen Y,Liu M,Guo Y,Lu M

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Jun 11 00:00:00 EDT 2019

IL-31 plays dual roles in lung inflammation in an OVA-induced murine asthma model.

Biology open

Huang J,Yue H,Jiang T,Gao J,Shi Y,Shi B,Wu X,Gou X

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Jan 15 00:00:00 EST 2019

Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.

Anti-cancer drugs

Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.

Anti-cancer drugs

Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses.

NPJ vaccines

Li G,Adam A,Luo H,Shan C,Cao Z,Fontes-Garfias CR,Sarathy VV,Teleki C,Winkelmann ER,Liang Y,Sun J,Bourne N,Barrett ADT,Shi PY,Wang T

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Next Generation Sequencing for Long Non-coding RNAs Profile for CD4⁺ T Cells in the Mouse Model of Acute Asthma.

Frontiers in genetics

Wang Z,Ji N,Chen Z,Wu C,Sun Z,Yu W,Hu F,Huang M,Zhang M

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Apr 08 00:00:00 EDT 2022

Sex Differences in Mouse Popliteal Lymph Nodes.

Scientific reports

Dill-Garlow R,Chen KE,Walker AM

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Jan 30 00:00:00 EST 2019

TLR1/2 Specific Small-Molecule Agonist Suppresses Leukemia Cancer Cell Growth by Stimulating Cytotoxic T Lymphocytes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cen X,Zhu G,Yang J,Yang J,Guo J,Jin J,Nandakumar KS,Yang W,Yin H,Liu S,Cheng K

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri May 17 00:00:00 EDT 2019

Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles.

Cell reports

Cianciaruso C,Beltraminelli T,Duval F,Nassiri S,Hamelin R,Mozes A,Gallart-Ayala H,Ceada Torres G,Torchia B,Ries CH,Ivanisevic J,De Palma M

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Jun 04 00:00:00 EDT 2019

Pharmacological inhibition of β-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating T_reg cells.

Science advances

Feng M,Jin JQ,Xia L,Xiao T,Mei S,Wang X,Huang X,Chen J,Liu M,Chen C,Rafi S,Zhu AX,Feng YX,Zhu D

11-0041 was used in Flow cytometry/Cell sorting to develop potent, selective inhibitors targeting the Wnt/B catenin pathway.

Wed May 01 00:00:00 EDT 2019

Amlexanox attenuates experimental autoimmune encephalomyelitis by inhibiting dendritic cell maturation and reprogramming effector and regulatory T cell responses.

Journal of neuroinflammation

Quan MY,Song XJ,Liu HJ,Deng XH,Hou HQ,Chen LP,Ma TZ,Han X,He XX,Jia Z,Guo L

11-0041-82 was used in Flow Cytometry to study the effect of ALX on the maturation of dendritic cells and the responses of effector and regulatory T cells.

Fri Mar 01 00:00:00 EST 2019

Epithelial EP4 plays an essential role in maintaining homeostasis in colon.

Scientific reports

Matsumoto Y,Nakanishi Y,Yoshioka T,Yamaga Y,Masuda T,Fukunaga Y,Sono M,Yoshikawa T,Nagao M,Araki O,Ogawa S,Goto N,Hiramatsu Y,Breyer RM,Fukuda A,Seno H

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunohistochemistry

Wed Oct 23 00:00:00 EDT 2019

The IRE1α Arm of UPR Regulates Muscle Cells Immune Characters by Restraining p38 MAPK Activation.

Frontiers in physiology

Gu R,Huang T,Xiao J,Liao Z,Li J,Lan H,Ouyang J,Hu J,Liao H

11-0041-82 was used in Flow Cytometry to demonstrate that p38 MAPK contributes greatly to IRE1α arm-dependent immunobiological suppression in myocytes under inflammatory stress conditions.

Wed Sep 30 00:00:00 EDT 2020

MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner.

Frontiers in immunology

Demeyer A,Skordos I,Driege Y,Kreike M,Hochepied T,Baens M,Staal J,Beyaert R

11-0041 was used in Flow cytometry/Cell sorting to establish that suppression of autoimmune responses is due to the T-cell intrinsic role of MALT1 proteolytic activity.

Mon Oct 05 00:00:00 EDT 2020

The Inhibitory T Cell Receptors PD1 and 2B4 Are Differentially Regulated on CD4 and CD8 T Cells in a Mouse Model of Non-alcoholic Steatohepatitis.

Frontiers in pharmacology

Hansel C,Erschfeld S,Baues M,Lammers T,Weiskirchen R,Trautwein C,Kroy DC,Drescher HK

11-0041 was used in Flow cytometry/Cell sorting to investigate the expression profile of inhibitory T cell receptors on CD4 and CD8 T cells in a mouse model of non-alcoholic steatohepatitis.

Wed Sep 30 00:00:00 EDT 2020

Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production.

Frontiers in immunology

Kiss MG,Ozsvár-Kozma M,Porsch F,Göderle L,Papac-Miličević N,Bartolini-Gritti B,Tsiantoulas D,Pickering MC,Binder CJ

11-0041-82 was used in Flow Cytometry to indicate that CFH, through its function as a complement repressor, acts as a negative regulator of BCR signaling and limits autoimmunity.

Tue Oct 13 00:00:00 EDT 2020

Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells.

Immunity

Halim TYF,Rana BMJ,Walker JA,Kerscher B,Knolle MD,Jolin HE,Serrao EM,Haim-Vilmovsky L,Teichmann SA,Rodewald HR,Botto M,Vyse TJ,Fallon PG,Li Z,Withers DR,McKenzie ANJ

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Jun 19 00:00:00 EDT 2018

E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.

Immunity

Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC

11-0041 was used in Immunohistochemistry to indicate that the VHL-HIF-glycolysis axis is essential for the late-stage maturation and function of ILC2s via targeting IL-33-ST2 pathway.

Tue Feb 20 00:00:00 EST 2018

CD150^high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine.

Cell stem cell

Hirata Y,Furuhashi K,Ishii H,Li HW,Pinho S,Ding L,Robson SC,Frenette PS,Fujisaki J

11-0041-82 was used in Flow Cytometry to describe a Treg subpopulation that controls hematopoietic stem cell (HSC) quiescence and engraftment.

Thu Mar 01 00:00:00 EST 2018

Insulin resistance causes inflammation in adipose tissue.

The Journal of clinical investigation

Shimobayashi M,Albert V,Woelnerhanssen B,Frei IC,Weissenberger D,Meyer-Gerspach AC,Clement N,Moes S,Colombi M,Meier JA,Swierczynska MM,Jenö P,Beglinger C,Peterli R,Hall MN

11-0041 was used in Flow cytometry/Cell sorting to elucidate the causal relationship between obesity-induced insulin resistance, and macrophage accumulation and inflammation in adipose tissue.

Mon Apr 02 00:00:00 EDT 2018

Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling.

The Journal of clinical investigation

Emmerson A,Trevelin SC,Mongue-Din H,Becker PD,Ortiz C,Smyth LA,Peng Q,Elgueta R,Sawyer G,Ivetic A,Lechler RI,Lombardi G,Shah AM

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Jul 02 00:00:00 EDT 2018

An OX40/OX40L interaction directs successful immunity to hepatitis B virus.

Science translational medicine

Publicover J,Gaggar A,Jespersen JM,Halac U,Johnson AJ,Goodsell A,Avanesyan L,Nishimura SL,Holdorf M,Mansfield KG,Judge JB,Koshti A,Croft M,Wakil AE,Rosenthal P,Pai E,Cooper S,Baron JL

11-0041 was used in Flow cytometry/Cell sorting to study the mechanistic action of the immune pathways and cells necessary for HBV immunity and identify potential therapeutic targets for resolving chronic HBV infection.

Wed Mar 21 00:00:00 EDT 2018

PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8⁺ T-Cell-Driven Antitumor Immunity.

Clinical cancer research : an official journal of the American Association for Cancer Research

Buchan SL,Fallatah M,Thirdborough SM,Taraban VY,Rogel A,Thomas LJ,Penfold CA,He LZ,Curran MA,Keler T,Al-Shamkhani A

11-0041 was used in Flow cytometry/Cell sorting to show that suboptimal T-cell invigoration in cancer patients undergoing treatment with PD-1 checkpoint blockers will be improved by dual PD-1 blockade and CD27 agonism.

Tue May 15 00:00:00 EDT 2018

Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.

Molecular therapy : the journal of the American Society of Gene Therapy

Ricca JM,Oseledchyk A,Walther T,Liu C,Mangarin L,Merghoub T,Wolchok JD,Zamarin D

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Apr 04 00:00:00 EDT 2018

Multipotent Adult Progenitor Cells Suppress T Cell Activation in In Vivo Models of Homeostatic Proliferation in a Prostaglandin E2-Dependent Manner.

Frontiers in immunology

Carty F,Corbett JM,Cunha JPMCM,Reading JL,Tree TIM,Ting AE,Stubblefield SR,English K

11-0041 was used in Flow cytometry/Cell sorting to investigate, using a mouse model of homeostatic proliferation, the immunosuppressive properties of multipotent adult progenitor cells, through their ability to control T cell proliferation.

Tue Jun 25 00:00:00 EDT 2019

NH36 and F3 Antigen-Primed Dendritic Cells Show Preserved Migrating Capabilities and CCR7 Expression and F3 Is Effective in Immunotherapy of Visceral Leishmaniasis.

Frontiers in immunology

Nico D,Martins Almeida F,Maria Motta J,Soares Dos Santos Cardoso F,Freire-de-Lima CG,Freire-de-Lima L,de Luca PM,Maria Blanco Martinez A,Morrot A,Palatnik-de-Sousa CB

11-0041 was used in Flow cytometry/Cell sorting to assess whether NH36 or the F3 peptide are capable of preventing the migrating effect of dendritic cells by restoring the expression of CCR7 receptors.

Thu Jul 11 00:00:00 EDT 2019

A fully-virulent retargeted oncolytic HSV armed with IL-12 elicits local immunity and vaccine therapy towards distant tumors.

PLoS pathogens

Leoni V,Vannini A,Gatta V,Rambaldi J,Sanapo M,Barboni C,Zaghini A,Nanni P,Lollini PL,Casiraghi C,Campadelli-Fiume G

11-0041 was used in Flow cytometry/Cell sorting to analyse the efficacy of a fully-virulent HER2-retargeted oncolytic HSV, demonstrating its ability to elicit a local immune response and systemic therapy vaccine effects.

Wed Aug 01 00:00:00 EDT 2018

MicroRNA-126 deficiency enhanced the activation and function of CD4⁺ T cells by elevating IRS-1 pathway.

Clinical and experimental immunology

Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells.

World journal of gastroenterology

Müller-Graff FT,Fitzner B,Jaster R,Vollmar B,Zechner D

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Sat Jul 28 00:00:00 EDT 2018

Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells.

World journal of gastroenterology

Müller-Graff FT,Fitzner B,Jaster R,Vollmar B,Zechner D

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Sat Jul 28 00:00:00 EDT 2018

Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells.

World journal of gastroenterology

Müller-Graff FT,Fitzner B,Jaster R,Vollmar B,Zechner D

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Sat Jul 28 00:00:00 EDT 2018

Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.

Evidence-based complementary and alternative medicine : eCAM

Pang P,Zheng K,Wu S,Xu H,Deng L,Shi Y,Chen X

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.

eLife

Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Nov 20 00:00:00 EST 2018

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.

Journal of neuroinflammation

Unger MS,Schernthaner P,Marschallinger J,Mrowetz H,Aigner L

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Sep 21 00:00:00 EDT 2018

Plasmodium co-infection protects against chikungunya virus-induced pathologies.

Nature communications

Teo TH,Lum FM,Ghaffar K,Chan YH,Amrun SN,Tan JJL,Lee CYP,Chua TK,Carissimo G,Lee WWL,Claser C,Rajarethinam R,Rénia L,Ng LFP

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Sep 25 00:00:00 EDT 2018

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects.

Journal of experimental & clinical cancer research : CR

Xu L,Zhang Y,Tian K,Chen X,Zhang R,Mu X,Wu Y,Wang D,Wang S,Liu F,Wang T,Zhang J,Liu S,Zhang Y,Tu C,Liu H

11-0041 was used in Flow cytometry/Cell sorting to investigate the effects of the flavonoid apigenin on the PD-L1 expression and the tumourigenesis of melanoma.

Mon Oct 29 00:00:00 EDT 2018

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects.

Journal of experimental & clinical cancer research : CR

Xu L,Zhang Y,Tian K,Chen X,Zhang R,Mu X,Wu Y,Wang D,Wang S,Liu F,Wang T,Zhang J,Liu S,Zhang Y,Tu C,Liu H

11-0041 was used in Flow cytometry/Cell sorting to investigate the effects of the flavonoid apigenin on the PD-L1 expression and the tumourigenesis of melanoma.

Mon Oct 29 00:00:00 EDT 2018

Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.

Nature communications

Xu Y,Ikeda S,Sumida K,Yamamoto R,Tanaka H,Minato N

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Mar 02 00:00:00 EST 2018

Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.

JCI insight

McCall CE,Zabalawi M,Liu T,Martin A,Long DL,Buechler NL,Arts RJW,Netea M,Yoza BK,Stacpoole PW,Vachharajani V

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Aug 09 00:00:00 EDT 2018

CD4⁺ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema.

Nature communications

García Nores GD,Ly CL,Cuzzone DA,Kataru RP,Hespe GE,Torrisi JS,Huang JJ,Gardenier JC,Savetsky IL,Nitti MD,Yu JZ,Rehal S,Mehrara BJ

11-0041 was used in Flow cytometry/Cell sorting to demonstrate that blocking T cell release from lymph nodes using a sphingosine-1-phosphate receptor modulator prevents lymphedema.

Thu May 17 00:00:00 EDT 2018

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.

eLife

Lian G,Gnanaprakasam JR,Wang T,Wu R,Chen X,Liu L,Shen Y,Yang M,Yang J,Chen Y,Vasiliou V,Cassel TA,Green DR,Liu Y,Fan TW,Wang R

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Sep 10 00:00:00 EDT 2018

SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2.

Nature communications

Singh AK,Khare P,Obaid A,Conlon KP,Basrur V,DePinho RA,Venuprasad K

11-0041 was used in Flow cytometry/Cell sorting to define the molecular mechanisms that govern the transcription factor activity of ROR-γt in the regulation of IL-17.

Tue Oct 30 00:00:00 EDT 2018

Orally administered heat-killed Lactobacillus paracasei MCC1849 enhances antigen-specific IgA secretion and induces follicular helper T cells in mice.

PloS one

Arai S,Iwabuchi N,Takahashi S,Xiao JZ,Abe F,Hachimura S

11-0041 was used in Flow cytometry/Cell sorting to investigate the effects of orally administered heat-killed MCC1849 on IgA production in the intestine and on Tfh cell induction in vivo.

Wed Jan 02 00:00:00 EST 2019

A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.

Nature communications

Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Apr 18 00:00:00 EDT 2018

Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Peng J,Xiao Y,Li W,Yang Q,Tan L,Jia Y,Qu Y,Qian Z

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue May 01 00:00:00 EDT 2018

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.

Nature communications

Cho S,Lee HM,Yu IS,Choi YS,Huang HY,Hashemifar SS,Lin LL,Chen MC,Afanasiev ND,Khan AA,Lin SW,Rudensky AY,Crotty S,Lu LF

11-0041 was used in Flow cytometry/Cell sorting to reveal differential cell-intrinsic regulations of GC B and Tfh cells by miR-146a and miR-146b.

Mon Jul 16 00:00:00 EDT 2018

Trichinella spiralis Infection Mitigates Collagen-Induced Arthritis via Programmed Death 1-Mediated Immunomodulation.

Frontiers in immunology

Cheng Y,Zhu X,Wang X,Zhuang Q,Huyan X,Sun X,Huang J,Zhan B,Zhu X

11-0041 was used in Flow cytometry/Cell sorting to introduce the first evidence that PD-1 plays a critical role in Trichinella spiralis infection-attenuated collagen-induced arthritis in a mouse model by regulating the CD4+ T cell function, which may provide the new insights into the mechanisms of helminth-induced immunomodulation of host autoimmunity.

Mon Jan 28 00:00:00 EST 2019

Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells.

Cell reports

Kirkling ME,Cytlak U,Lau CM,Lewis KL,Resteu A,Khodadadi-Jamayran A,Siebel CW,Salmon H,Merad M,Tsirigos A,Collin M,Bigley V,Reizis B

11-0041 was used in Flow cytometry/Cell sorting to examine the role of Notch signalling in the in vitro generation of classical dendritic cells.

Tue Jun 19 00:00:00 EDT 2018

The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING.

Cell reports

Li S,Hong Z,Wang Z,Li F,Mei J,Huang L,Lou X,Zhao S,Song L,Chen W,Wang Q,Liu H,Cai Y,Yu H,Xu H,Zeng G,Wang Q,Zhu J,Liu X,Tan N,Wang C

11-0041 was used in Flow cytometry/Cell sorting to characterise a STING-specific small-molecular inhibitor that may be applied for potentially manipulating the STING-mediated clinical diseases.

Tue Dec 18 00:00:00 EST 2018

Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung.

Frontiers in physiology

Lim D,Kim W,Lee C,Bae H,Kim J

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

In utero nanoparticle delivery for site-specific genome editing.

Nature communications

Ricciardi AS,Bahal R,Farrelly JS,Quijano E,Bianchi AH,Luks VL,Putman R,López-Giráldez F,Coşkun S,Song E,Liu Y,Hsieh WC,Ly DH,Stitelman DH,Glazer PM,Saltzman WM

11-0041 was used in Flow cytometry/Cell sorting to demonstrate the safe intravenous and intra-amniotic administration of polymeric nanoparticles to foetal mouse tissues at selected gestational ages with no effect on survival or postnatal growth.

Tue Jun 26 00:00:00 EDT 2018

Sumoylation of RORγt regulates T_H17 differentiation and thymocyte development.

Nature communications

He Z,Zhang J,Huang Z,Du Q,Li N,Zhang Q,Chen Y,Sun Z

11-0041 was used in Flow cytometry/Cell sorting to study the mechanism underlying the regulation of RORyt function.

Mon Nov 19 00:00:00 EST 2018

Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice.

mSphere

Quach D,Collins F,Parameswaran N,McCabe L,Britton RA

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation.

Nature communications

Li H,Yao Q,Mariscal AG,Wu X,Hülse J,Pedersen E,Helin K,Waisman A,Vinkel C,Thomsen SF,Avgustinova A,Benitah SA,Lovato P,Norsgaard H,Mortensen MS,Veng L,Rozell B,Brakebusch C

11-0041 was used in Flow cytometry/Cell sorting to show that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation with an IL-17 profile in mice.

Thu Apr 12 00:00:00 EDT 2018

Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.

Immunity, inflammation and disease

Omodho B,Miao T,Symonds ALJ,Singh R,Li S,Wang P

11-0041 was used in Flow cytometry/Cell sorting to show that despite impaired proliferation and IL2 production, tolerant T cells can display inflammatory responses in response to antigen stimulation and this is controlled at least partly by Egr2 and 3.

Fri Jun 01 00:00:00 EDT 2018

Store-Operated Ca²⁺ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.

Immunity

Vaeth M,Maus M,Klein-Hessling S,Freinkman E,Yang J,Eckstein M,Cameron S,Turvey SE,Serfling E,Berberich-Siebelt F,Possemato R,Feske S

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

Direct Pharmacological Targeting of a Mitochondrial Ion Channel Selectively Kills Tumor Cells In Vivo.

Cancer cell

Leanza L,Romio M,Becker KA,Azzolini M,Trentin L,Managò A,Venturini E,Zaccagnino A,Mattarei A,Carraretto L,Urbani A,Kadow S,Biasutto L,Martini V,Severin F,Peruzzo R,Trimarco V,Egberts JH,Hauser C,Visentin A,Semenzato G,Kalthoff H,Zoratti M,Gulbins E,Paradisi C,Szabo I

11-0041 was used in Flow cytometry/Cell sorting to demonstrate that specific pharmacological targeting of a mitochondrial potassium channel can lead to reactive oxygen species-mediated selective apoptosis of cancer cells in vivo, without significant side effects.

Mon Apr 10 00:00:00 EDT 2017

Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis.

Gastroenterology

King A,Houlihan DD,Kavanagh D,Haldar D,Luu N,Owen A,Suresh S,Than NN,Reynolds G,Penny J,Sumption H,Ramachandran P,Henderson NC,Kalia N,Frampton J,Adams DH,Newsome PN

11-0041 was used in Flow cytometry/Cell sorting to investigate the role of sphingosine-1-phosphate in the response of hematopoietic stem cells to liver fibrosis in mice.

Sat Jul 01 00:00:00 EDT 2017

Commensal Fungi Recapitulate the Protective Benefits of Intestinal Bacteria.

Cell host & microbe

Jiang TT,Shao TY,Ang WXG,Kinder JM,Turner LH,Pham G,Whitt J,Alenghat T,Way SS

11-0041 was used in Flow cytometry/Cell sorting to show that commensal fungi can functionally replace intestinal bacteria by conferring protection against injury to mucosal tissues and positively calibrating the responsiveness of circulating immune cells.

Wed Dec 13 00:00:00 EST 2017

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.

The Journal of clinical investigation

Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

The Journal of experimental medicine

Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Jun 05 00:00:00 EDT 2017

GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia.

Developmental cell

Hewitt KJ,Katsumura KR,Matson DR,Devadas P,Tanimura N,Hebert AS,Coon JJ,Kim JS,Dewey CN,Keles S,Hao S,Paulson RF,Bresnick EH

11-0041 was used in Flow cytometry/Cell sorting to propose that Samd14-Enh and an ensemble of anemia-responsive enhancers are essential for erythrocyte regeneration in stress erythropoiesis.

Mon Aug 07 00:00:00 EDT 2017

Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.

Cancer research

Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B

11-0041-82 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.

Wed Nov 01 00:00:00 EDT 2017

Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination.

Cancer research

Jiang H,Rivera-Molina Y,Gomez-Manzano C,Clise-Dwyer K,Bover L,Vence LM,Yuan Y,Lang FF,Toniatti C,Hossain MB,Fueyo J

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Sat Jul 15 00:00:00 EDT 2017

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

Proceedings of the National Academy of Sciences of the United States of America

Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Mar 21 00:00:00 EDT 2017

Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b⁺Ly6G⁺ intratumor myeloid cells through the TICAM-1 signaling pathway.

Cell death and differentiation

Shime H,Matsumoto M,Seya T

11-0041 was used in Flow cytometry/Cell sorting to study the response of CD11b+Ly6G+ granulocytic myeloid-derived suppressor cells to polyI:C in an EL4 tumour implant model.

Wed Mar 01 00:00:00 EST 2017

Modulation of Endoplasmic Reticulum Stress Controls CD4⁺ T-cell Activation and Antitumor Function.

Cancer immunology research

Thaxton JE,Wallace C,Riesenberg B,Zhang Y,Paulos CM,Beeson CC,Liu B,Li Z

11-0041 was used in Flow cytometry/Cell sorting to investigate whether the endoplasmic reticulum stress response may be important for CD4+ T-cell activation and whether gp96 is integral to this process.

Tue Aug 01 00:00:00 EDT 2017

PI3Kγ Activates Integrin α₄ and Promotes Immune Suppressive Myeloid Cell Polarization during Tumor Progression.

Cancer immunology research

Foubert P,Kaneda MM,Varner JA

11-0041 was used in Flow cytometry/Cell sorting to highlight PI3Kγ and integrin α4 as targets for the design of cancer therapeutics.

Wed Nov 01 00:00:00 EDT 2017

Upregulation of Intestinal Barrier Function in Mice with DSS-Induced Colitis by a Defined Bacterial Consortium Is Associated with Expansion of IL-17A Producing Gamma Delta T Cells.

Frontiers in immunology

Li M,Wang B,Sun X,Tang Y,Wei X,Ge B,Tang Y,Deng Y,He C,Yuan J,Li X

11-0041 was used in Flow cytometry/Cell sorting to investigate bacterial consortium transplantation as a treatment for IBD, showing an upregulation of intestinal barrier function associated with expansion of IL-17A producing gamma delta T cells.

Wed Nov 20 00:00:00 EST 2019

Ras Signaling Inhibitors Attenuate Disease in Adjuvant-Induced Arthritis via Targeting Pathogenic Antigen-Specific Th17-Type Cells.

Frontiers in immunology

Zayoud M,Marcu-Malina V,Vax E,Jacob-Hirsch J,Elad-Sfadia G,Barshack I,Kloog Y,Goldstein I

11-0041 was used in Flow cytometry/Cell sorting to test the therapeutic and immunomodulatory effects of farnesylthiosalicylic acid and its derivative 5-fluoro-FTS in the rat adjuvant-induced arthritis model.

Wed Nov 20 00:00:00 EST 2019

IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection.

PLoS pathogens

Valanparambil RM,Tam M,Gros PP,Auger JP,Segura M,Gros P,Jardim A,Geary TG,Ozato K,Stevenson MM

11-0041 was used in Flow cytometry/Cell sorting to study the role of interferon regulatory factor-8 on Th2 immunity to Helimosomoides polygyrus bakeri infection.

Sun Oct 01 00:00:00 EDT 2017

Genetic Nrf2 Overactivation Inhibits the Deleterious Effects Induced by Hepatocyte-Specific c-met Deletion during the Progression of NASH.

Oxidative medicine and cellular longevity

Ramadori P,Drescher H,Erschfeld S,Fragoulis A,Kensler TW,Wruck CJ,Cubero FJ,Trautwein C,Streetz KL,Kroy DC

11-0041 was used in Flow cytometry/Cell sorting to elucidate the effect of Nrf2 overactivation on cellular events in c-met deficient hepatocytes.

Wed Jan 31 00:00:00 EST 2018

Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.

Acta pharmacologica Sinica

Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

CD8+ T cells produce a dialyzable antigen-specific activator of dendritic cells.

Journal of leukocyte biology

Myles IA,Zhao M,Nardone G,Olano LR,Reckhow JD,Saleem D,Break TJ,Lionakis MS,Myers TG,Gardina PJ,Kirkpatrick CH,Holland SM,Datta SK

11-0041 was used in Flow cytometry/Cell sorting to show that extracts from antigen-targeted T cells enhance immunity to Staphylococcus aureus and Candida albicans.

Sun Jan 01 00:00:00 EST 2017

Cornea lymphatics drive the CD8⁺ T-cell response to herpes simplex virus-1.

Immunology and cell biology

Gurung HR,Carr MM,Carr DJ

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2017

Pathogenic roles of CXCL10 signaling through CXCR3 and TLR4 in macrophages and T cells: relevance for arthritis.

Arthritis research & therapy

Lee JH,Kim B,Jin WJ,Kim HH,Ha H,Lee ZH

11-0041 was used in Immunohistochemistry-immunofluorescence to highlight the importance of CXCL10 signaling in the pathogenesis of RA and provide previously unidentified details of the mechanisms by which CXCL10 promotes the development of arthritis.

Wed Jul 19 00:00:00 EDT 2017

ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.

RNA biology

Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu May 04 00:00:00 EDT 2017

ID3 may protect mice from anti‑GBM glomerulonephritis by regulating the differentiation of Th17 and Treg cells.

Molecular medicine reports

Zhou H,Wang L,Xu Q,Liu Q,Liu H,Qiu W,Hu T,Lv Y,Zhang Q

Fri Dec 01 00:00:00 EST 2017

A polysaccharide component from Strongylocentrotus nudus eggs inhibited hepatocellular carcinoma in mice by activating T lymphocytes.

Oncology letters

Zhang M,Liu Y,Li J,Ke M,Yu J,Dou J,Wang H,Zhou C

Wed Mar 01 00:00:00 EST 2017

Location of tumor affects local and distant immune cell type and number.

Immunity, inflammation and disease

Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

TLR2^-/- Mice Display Increased Clearance of Dermatophyte Trichophyton mentagrophytes in the Setting of Hyperglycemia.

Frontiers in cellular and infection microbiology

Almeida DF,Fraga-Silva TF,Santos AR,Finato AC,Marchetti CM,Golim MA,Lara VS,Arruda MS,Venturini J

11-0041 was used in Flow cytometry/Cell sorting to demonstrate that TLR2 diminishes the development of adaptive immune responses during experimental deep dermatophytosis and, in a diabetic scenario, acts to intensify a non-protective inflammatory response.

Mon Sep 18 00:00:00 EDT 2017

Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury.

Stem cell research & therapy

Zhu D,Tan J,Maleken AS,Muljadi R,Chan ST,Lau SN,Elgass K,Leaw B,Mockler J,Chambers D,Leeman KT,Kim CF,Wallace EM,Lim R

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Nov 10 00:00:00 EST 2017

Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.

Scientific reports

Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H

11-0041 was used in Flow cytometry/Cell sorting to investigate the effect Paeoniflorin has on Th cells and dendritic cells in a mouse MS model.

Mon Feb 06 00:00:00 EST 2017

Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery.

Scientific reports

Ai J,Li J,Gessler DJ,Su Q,Wei Q,Li H,Gao G

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunofluorescence

Mon Jan 09 00:00:00 EST 2017

MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis.

Stem cell reports

Shigemoto-Kuroda T,Oh JY,Kim DK,Jeong HJ,Park SY,Lee HJ,Park JW,Kim TW,An SY,Prockop DJ,Lee RH

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue May 09 00:00:00 EDT 2017

IFNGR1 signaling is associated with adverse pregnancy outcomes during infection with malaria parasites.

PloS one

Niikura M,Inoue SI,Mineo S,Asahi H,Kobayashi F

11-0041 was used in Flow cytometry/Cell sorting to explore the role of IFN-γ receptor 1 signalling in placental pathology during severe malaria using luciferase-expressing rodent malaria parasites, P. berghei NK65.

Wed Nov 29 00:00:00 EST 2017

Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mice by Selectively Altering the Gut Microbiota and Promoting Intestinal Gamma-Delta T Cells.

Frontiers in pharmacology

Li M,Gao J,Tang Y,Liu M,Wu S,Qu K,Long X,Li H,Liu M,Liu Y,Yuan J,Mao L,Liu Y,Zheng X,Wang E,Wang J,Yang Y

Wed Sep 30 00:00:00 EDT 2020

Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies.

PloS one

Min M,Yan BX,Wang P,Landeck L,Chen JQ,Li W,Cai SQ,Zheng M,Man XY

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Jan 16 00:00:00 EST 2018

Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program.

Cell reports

Mehta C,Johnson KD,Gao X,Ong IM,Katsumura KR,McIver SC,Ranheim EA,Bresnick EH

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Sep 19 00:00:00 EDT 2017

Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation.

JCI insight

Tischner D,Grimm M,Kaur H,Staudenraus D,Carvalho J,Looso M,Günther S,Wanke F,Moos S,Siller N,Breuer J,Schwab N,Zipp F,Waisman A,Kurschus FC,Offermanns S,Wettschureck N

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Aug 03 00:00:00 EDT 2017

Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.

Oncoimmunology

Huang RY,Francois A,McGray AR,Miliotto A,Odunsi K

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.

JCI insight

Azzam KM,Madenspacher JH,Cain DW,Lai L,Gowdy KM,Rai P,Janardhan K,Clayton N,Cunningham W,Jensen H,Patel PS,Kearney JF,Taylor GA,Fessler MB

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Aug 17 00:00:00 EDT 2017

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.

Nature communications

Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Feb 13 00:00:00 EST 2017

A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation.

EBioMedicine

Ma J,Teng X,Wang X,Fan X,Wu Y,Tian M,Zhou Z,Li L

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated with Suppressed Inflammatory Transcriptional Networks in the Mouse Colon.

Frontiers in physiology

Yang T,Ahmari N,Schmidt JT,Redler T,Arocha R,Pacholec K,Magee KL,Malphurs W,Owen JL,Krane GA,Li E,Wang GP,Vickroy TW,Raizada MK,Martyniuk CJ,Zubcevic J

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunofluorescence

Thu Oct 01 00:00:00 EDT 2020

Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease.

Scientific reports

Ogawa Y,He H,Mukai S,Imada T,Nakamura S,Su CW,Mahabole M,Tseng SC,Tsubota K

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunohistochemistry

Mon Feb 06 00:00:00 EST 2017

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Cell

Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Oct 06 00:00:00 EDT 2016

Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.

Cell

Wang A,Huen SC,Luan HH,Yu S,Zhang C,Gallezot JD,Booth CJ,Medzhitov R

11-0041 was used in an ELISA assay to analyse the effects of anorxia in mouse models wih viral and bacterial infections.

Thu Sep 08 00:00:00 EDT 2016

Foxp3 and Toll-like receptor signaling balance T_reg cell anabolic metabolism for suppression.

Nature immunology

Gerriets VA,Kishton RJ,Johnson MO,Cohen S,Siska PJ,Nichols AG,Warmoes MO,de Cubas AA,MacIver NJ,Locasale JW,Turka LA,Wells AD,Rathmell JC

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2016

NLRP2 controls age-associated maternal fertility.

The Journal of experimental medicine

Kuchmiy AA,D'Hont J,Hochepied T,Lamkanfi M

11-0041 was used in Flow cytometry/Cell sorting to identify Nlrp2 as a critical regulator of oocyte quality.

Mon Dec 12 00:00:00 EST 2016

CD8⁺ T cells drive autoimmune hematopoietic stem cell dysfunction and bone marrow failure.

Journal of autoimmunity

Gravano DM,Al-Kuhlani M,Davini D,Sanders PD,Manilay JO,Hoyer KK

11-0041 was used in Flow cytometry/Cell sorting to investigate whether CD8+ T cells play a non-redundant role in driving bone marrow failure.

Thu Dec 01 00:00:00 EST 2016

The Effect of a BSA Conjugate of a Synthetic Hexasaccharide Related to the Fragment of Capsular Polysaccharide of Streptococcus pneumoniae Type 14 on the Activation of Innate and Adaptive Immune Responses.

Frontiers in immunology

Akhmatova NK,Kurbatova EA,Akhmatov EA,Egorova NB,Logunov DY,Gening ML,Sukhova EV,Yashunsky DV,Tsvetkov YE,Nifantiev NE

11-0041 was used in Flow cytometry/Cell sorting to evaluate the effects of immunisation with a synthetic hexasaccharide conjugate, with and without an adjuvant, on TLR activation, dendritic cell maturation, and cytokine production in mice.

Fri Jul 22 00:00:00 EDT 2016

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.

Immunology

Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2016

Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection.

European journal of immunology

Venkatasubramanian S,Tripathi D,Tucker T,Paidipally P,Cheekatla S,Welch E,Raghunath A,Jeffers A,Tvinnereim AR,Schechter ME,Andrade BB,Mackman N,Idell S,Vankayalapati R

11-0041 was used in Flow cytometry/Cell sorting to determine the role of tissue factor expressed by myeloid cells during Mycobacterium tuberculosis infection.

Mon Feb 01 00:00:00 EST 2016

p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.

European journal of immunology

Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Intranasal immunization with heat shock protein 60 induces CD4(+) CD25(+) GARP(+) and type 1 regulatory T cells and inhibits early atherosclerosis.

Clinical and experimental immunology

Zhong Y,Tang H,Wang X,Zeng Q,Liu Y,Zhao XI,Yu K,Shi H,Zhu R,Mao X

11-0041 was used in Flow cytometry/Cell sorting to investigate the impact of nasal heat shock protein 60 on atherosclerosis and the mechanisms underlying the anti-atherosclerosis responses.

Tue Mar 01 00:00:00 EST 2016

Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.

Journal of immunology (Baltimore, Md. : 1950)

Menendez CM,Jinkins JK,Carr DJ

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Aug 15 00:00:00 EDT 2016

Multispectral Imaging of T and B Cells in Murine Spleen and Tumor.

Journal of immunology (Baltimore, Md. : 1950)

Feng Z,Jensen SM,Messenheimer DJ,Farhad M,Neuberger M,Bifulco CB,Fox BA

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunofluorescence

Sun May 01 00:00:00 EDT 2016

Overexpression of a glucokinase point mutant in the treatment of diabetes mellitus.

Gene therapy

Lu G,Teng X,Zheng Z,Zhang R,Peng L,Zheng F,Liu J,Huang H,Xiong H

11-0041 was used in Flow cytometry/Cell sorting to study the role of Glucokinase in glucose metabolism and assess its potential as a target to treat diabetes.

Fri Apr 01 00:00:00 EDT 2016

Overexpression of a glucokinase point mutant in the treatment of diabetes mellitus.

Gene therapy

Lu G,Teng X,Zheng Z,Zhang R,Peng L,Zheng F,Liu J,Huang H,Xiong H

11-0041 was used in Flow cytometry/Cell sorting to study the role of Glucokinase in glucose metabolism and assess its potential as a target to treat diabetes.

Fri Apr 01 00:00:00 EDT 2016

Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.

Molecular medicine reports

Gu L,Deng WS,Sun XF,Zhou H,Xu Q

11-0041 was used in Immunofluorescence to study how rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.

Mon Aug 01 00:00:00 EDT 2016

PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.

Biology open

Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Sun May 15 00:00:00 EDT 2016

Human embryonic mesenchymal stem cells alleviate pathologic changes of MRL/Lpr mice by regulating Th7 cell differentiation.

Renal failure

Yuan L,Xiao ZT,Huang XZ,Wu MJ,Shi H,Liu AF

11-0041-82 was used in Flow cytometry/Cell sorting to suggest that hMSC therapy could alleviate systemic and local renal lesions in MRL/Lpr mice, probably by secreting immune regulating factors and regulating Th17 cell differentiation in MRL/Lpr mice.

Sat Oct 01 00:00:00 EDT 2016

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.

Nature communications

Brinkman CC,Iwami D,Hritzo MK,Xiong Y,Ahmad S,Simon T,Hippen KL,Blazar BR,Bromberg JS

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Jun 21 00:00:00 EDT 2016

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.

Nature communications

Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Jun 08 00:00:00 EDT 2016

Mycobacterium tuberculosis Induces Expansion of Foxp3 Positive CD4 T-cells with a Regulatory Profile in Tuberculin Non-sensitized Healthy Subjects: Implications for Effective Immunization against TB.

Journal of clinical & cellular immunology

Hirsch CS,Rojas R,Wu M,Toossi Z

11-0041 was used in Flow cytometry/Cell sorting to investigate the basis of iT-reg expansion in response to MTB stimulation, in the absence of prior T cell antigen responsiveness.

Wed Jun 01 00:00:00 EDT 2016

The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis.

PloS one

Braun J,Meixner A,Brachner A,Foisner R

11-0041 was used in Flow cytometry/Cell sorting to test whether ANKLE1 may contribute to Holliday junction resolution during DNA repair in mice.

Fri Aug 12 00:00:00 EDT 2016

Interleukin-10 deficiency impairs regulatory T cell-derived neuropilin-1 functions and promotes Th1 and Th17 immunity.

Scientific reports

Wang S,Gao X,Shen G,Wang W,Li J,Zhao J,Wei YQ,Edwards CK

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Apr 14 00:00:00 EDT 2016

NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.

Nature communications

Alrefai H,Muhammad K,Rudolf R,Pham DA,Klein-Hessling S,Patra AK,Avots A,Bukur V,Sahin U,Tenzer S,Goebeler M,Kerstan A,Serfling E

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed May 25 00:00:00 EDT 2016

Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice.

BMC complementary and alternative medicine

Zhang S,Liu X,Mei L,Wang H,Fang F

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Aug 31 00:00:00 EDT 2016

CD8(+) T-cell Immune Evasion Enables Oncolytic Virus Immunotherapy.

EBioMedicine

Pourchet A,Fuhrmann SR,Pilones KA,Demaria S,Frey AB,Mulvey M,Mohr I

11-0041 was used in Flow cytometry/Cell sorting to establish TAP inhibitor-armed OVs that evade CD8(+) T-cells as an immunotherapy strategy to elicit potent anti-tumour responses.

Tue Mar 01 00:00:00 EST 2016

MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.

eLife

Ogawa Y,Morikawa S,Okano H,Mabuchi Y,Suzuki S,Yaguchi T,Sato Y,Mukai S,Yaguchi S,Inaba T,Okamoto S,Kawakami Y,Tsubota K,Matsuzaki Y,Shimmura S

11-0041 was used in Flow cytometry/Cell sorting to investigate the fibrosis in a scleroderma mouse model which is triggered by antigen mismatched bone marrow stromal/stem cells.

Tue Jan 26 00:00:00 EST 2016

Dendritic cell-derived nitric oxide inhibits the differentiation of effector dendritic cells.

Oncotarget

Si C,Zhang R,Wu T,Lu G,Hu Y,Zhang H,Xu F,Wei P,Chen K,Tang H,Yeretssian G,Xiong H

11-0041 was used in Flow cytometry/Cell sorting to demonstrate that DC-derived nitric oxide restrains effector DC development to treat autoimmune and inflammatory diseases.

Tue Nov 15 00:00:00 EST 2016

Flagellin is a strong vaginal adjuvant of a therapeutic vaccine for genital cancer.

Oncoimmunology

Lee SE,Hong SH,Verma V,Lee YS,Duong TN,Jeong K,Uthaman S,Sung YC,Lee JT,Park IK,Min JJ,Rhee JH

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2016

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms.

Cell reports

Choi IY,Piccio L,Childress P,Bollman B,Ghosh A,Brandhorst S,Suarez J,Michalsen A,Cross AH,Morgan TE,Wei M,Paul F,Bock M,Longo VD

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Jun 07 00:00:00 EDT 2016

Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.

Nature communications

Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B

11-0041 was used in Flow cytometry/Cell sorting to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.

Mon Nov 21 00:00:00 EST 2016

Antigen presenting cell abnormalities in the Cln3(-/-) mouse model of juvenile neuronal ceroid lipofuscinosis.

Biochimica et biophysica acta

Hersrud SL,Kovács AD,Pearce DA

11-0041 was used in Flow cytometry/Cell sorting to show that CLN3 deficiency alters antigen presenting cells, which can contribute to the autoimmune response in juvenile neuronal ceroid lipofuscinosis.

Fri Jul 01 00:00:00 EDT 2016

TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection.

Cell reports

Schleicher U,Paduch K,Debus A,Obermeyer S,König T,Kling JC,Ribechini E,Dudziak D,Mougiakakos D,Murray PJ,Ostuni R,Körner H,Bogdan C

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue May 03 00:00:00 EDT 2016

Multicomponent LBSap vaccine displays immunological and parasitological profiles similar to those of Leish-Tec® and Leishmune® vaccines against visceral leishmaniasis.

Parasites & vectors

de Mendonça LZ,Resende LA,Lanna MF,Aguiar-Soares RD,Roatt BM,Castro RA,Batista MA,Silveira-Lemos D,Gomes Jde A,Fujiwara RT,Rezende SA,Martins-Filho OA,Corrêa-Oliveira R,Dutra WO,Reis AB,Giunchetti RC

11-0041 was used in Flow cytometry/Cell sorting to compare the effects of the multicomponent LBSap vaccine with those of Leish-Tec® and Leishmune®.

Tue Aug 30 00:00:00 EDT 2016

1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis.

Cell death & disease

Wei C,Mei J,Tang L,Liu Y,Li D,Li M,Zhu X

11-0041 was used in Flow cytometry/Cell sorting to investigate the high percentage of peritoneal Treg in endometriosis patients, showing that 1-Methyl-tryptophan attenuates Treg differentiation due to the inhibition of estrogen-IDO1-MRC2 axis.

Thu Dec 01 00:00:00 EST 2016

Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential.

PloS one

Qualai J,Li LX,Cantero J,Tarrats A,Fernández MA,Sumoy L,Rodolosse A,McSorley SJ,Genescà M

11-0041 was used in Flow cytometry/Cell sorting to find markers associated with non-conventional T cell subsets, including γδ T cells and invariant natural killer T cells.

Thu Mar 16 00:00:00 EDT 2017

Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.

Scientific reports

Ochi T,Feng Y,Kitamoto S,Nagao-Kitamoto H,Kuffa P,Atarashi K,Honda K,Teitelbaum DH,Kamada N

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Jun 15 00:00:00 EDT 2016

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Nature

Huang YH,Zhu C,Kondo Y,Anderson AC,Gandhi A,Russell A,Dougan SK,Petersen BS,Melum E,Pertel T,Clayton KL,Raab M,Chen Q,Beauchemin N,Yazaki PJ,Pyzik M,Ostrowski MA,Glickman JN,Rudd CE,Ploegh HL,Franke A,Petsko GA,Kuchroo VK,Blumberg RS

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Jan 15 00:00:00 EST 2015

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.

Nature biotechnology

Kim J,Li WA,Choi Y,Lewin SA,Verbeke CS,Dranoff G,Mooney DJ

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2015

Rapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis.

Nature immunology

Kim MS,Yan J,Wu W,Zhang G,Zhang Y,Cai D

11-0041 was used in Flow cytometry/Cell sorting to investigate the role of the brain in innate immunological signals, showing rapid linkage of innate signals and adaptive immunity by the brain-fat axis.

Fri May 01 00:00:00 EDT 2015

Recipient T cell TIM-3 and hepatocyte galectin-9 signalling protects mouse liver transplants against ischemia-reperfusion injury.

Journal of hepatology

Liu Y,Ji H,Zhang Y,Shen X,Gao F,He X,Li GA,Busuttil RW,Kuchroo VK,Kupiec-Weglinski JW

11-0041 was used in Flow cytometry/Cell sorting to investigate whether negative T cell-dependent TIM-3 co-stimulation rescues orthotopic liver transplants stressed by ischaemia-reperfusion from innate immunity-driven inflammation.

Sun Mar 01 00:00:00 EST 2015

Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner.

Blood

Yi W,Hu X,Chen Z,Liu L,Tian Y,Chen H,Cong YS,Yang F,Zhang L,Rudolph KL,Zhang Z,Zhao Y,Ju Z

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Jul 30 00:00:00 EDT 2015

IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.

The Journal of experimental medicine

Pallangyo CK,Ziegler PK,Greten FR

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Dec 14 00:00:00 EST 2015

Cis-regulatory mechanisms governing stem and progenitor cell transitions.

Science advances

Johnson KD,Kong G,Gao X,Chang YI,Hewitt KJ,Sanalkumar R,Prathibha R,Ranheim EA,Dewey CN,Zhang J,Bresnick EH

11-0041 was used in Flow cytometry/Cell sorting to illustrate a paradigm in which cis-elements in a locus differentially control stem and progenitor cell transitions.

Tue Sep 01 00:00:00 EDT 2015

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Developmental cell

Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunofluorescence

Mon Sep 14 00:00:00 EDT 2015

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Developmental cell

Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunofluorescence

Mon Sep 14 00:00:00 EDT 2015

B cell autophagy mediates TLR7-dependent autoimmunity and inflammation.

Autophagy

Weindel CG,Richey LJ,Bolland S,Mehta AJ,Kearney JF,Huber BT

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunohistochemistry

Mon Apr 18 00:00:00 EDT 2016

IFN-γ ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation.

Proceedings of the National Academy of Sciences of the United States of America

Sosa RA,Murphey C,Robinson RR,Forsthuber TG

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunofluorescence

Tue Sep 08 00:00:00 EDT 2015

Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.

Cell death and differentiation

Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse.

The Journal of cell biology

Na BR,Kim HR,Piragyte I,Oh HM,Kwon MS,Akber U,Lee HS,Park DS,Song WK,Park ZY,Im SH,Rho MC,Hyun YM,Kim M,Jun CD

11-0041 was used in Flow cytometry/Cell sorting to reveal a novel function of TAGLN2 in enhancing T cell responses.

Mon Apr 13 00:00:00 EDT 2015

Activated NKT cells imprint NK-cell differentiation, functionality and education.

European journal of immunology

Riese P,Trittel S,May T,Cicin-Sain L,Chambers BJ,Guzmán CA

11-0041 was used in Flow cytometry/Cell sorting to study the cellular cross-talk between natural killer T cells and natural killer cells.

Mon Jun 01 00:00:00 EDT 2015

Mice lacking Axl and Mer tyrosine kinase receptors are susceptible to experimental autoimmune orchitis induction.

Immunology and cell biology

Li N,Liu Z,Zhang Y,Chen Q,Liu P,Cheng CY,Lee WM,Chen Y,Han D

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2015

IFN-β Selectively Inhibits IL-2 Production through CREM-Mediated Chromatin Remodeling.

Journal of immunology (Baltimore, Md. : 1950)

Otero DC,Fares-Frederickson NJ,Xiao M,Baker DP,David M

11-0041 was used in Flow cytometry/Cell sorting to investigate the mechanism by which interferon beta limits T cell responses and its potential therapeutic use for multiple sclerosis.

Mon Jun 01 00:00:00 EDT 2015

B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses.

Journal of immunology (Baltimore, Md. : 1950)

Pone EJ,Lam T,Lou Z,Wang R,Chen Y,Liu D,Edinger AL,Xu Z,Casali P

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2015

MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR.

Journal of immunology (Baltimore, Md. : 1950)

Singh Y,Garden OA,Lang F,Cobb BS

11-0041 was used in Flow cytometry/Cell sorting to understand miRNA function in Treg development..

Tue Dec 15 00:00:00 EST 2015

Histone deacetylation of memory T lymphocytes by You-Gui-Wan alleviates allergen-induced eosinophilic airway inflammation in asthma.

Chinese medicine

Zhang HP,Fu JJ,Fan T,Zhang WB,Wang ZL,Wang L,Wang G

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Jun 15 00:00:00 EDT 2015

Modulatory Effects of Astragalus Polysaccharides on T-Cell Polarization in Mice with Polymicrobial Sepsis.

Mediators of inflammation

Hou YC,Wu JM,Wang MY,Wu MH,Chen KY,Yeh SL,Lin MT

11-0041 was used in Flow cytometry/Cell sorting to demonstrate that appropriate dosage of APS reduces Treg populations and elicits a more balanced Th1/Th2 response to attenuate sepsis-induced immunosuppression.

Tue Sep 20 00:00:00 EDT 2016

Control of the Survival and Growth of Human Glioblastoma Grafted Into the Spinal Cord of Mice by Taking Advantage of Immunorejection.

Cell transplantation

Itakura G,Kobayashi Y,Nishimura S,Iwai H,Takano M,Iwanami A,Toyama Y,Okano H,Nakamura M

11-0041 was used in Flow cytometry/Cell sorting to establish a glioblastoma multiforme xenograft model mouse.

Mon Apr 11 00:00:00 EDT 2016

Distinct Contributions of CD4+ and CD8+ T Cells to Pathogenesis of Trypanosoma brucei Infection in the Context of Gamma Interferon and Interleukin-10.

Infection and immunity

Liu G,Sun D,Wu H,Zhang M,Huan H,Xu J,Zhang X,Zhou H,Shi M

11-0041 was used in Immunocytochemistry to study the distinct roles of CD4 and CD8 T cells in the context of IFN-γ and IL-10 during Trypanosoma brucei infections.

Wed Jul 01 00:00:00 EDT 2015

Distinct Contributions of CD4+ and CD8+ T Cells to Pathogenesis of Trypanosoma brucei Infection in the Context of Gamma Interferon and Interleukin-10.

Infection and immunity

Liu G,Sun D,Wu H,Zhang M,Huan H,Xu J,Zhang X,Zhou H,Shi M

11-0041 was used in Immunocytochemistry to study the distinct roles of CD4 and CD8 T cells in the context of IFN-γ and IL-10 during Trypanosoma brucei infections.

Wed Jul 01 00:00:00 EDT 2015

Targeted Mutation of Nuclear Bone Morphogenetic Protein 2 Impairs Secondary Immune Response in a Mouse Model.

BioMed research international

Olsen DS,Goar WA,Nichols BA,Bailey KT,Christensen SL,Merriam KR,Reynolds PR,Wilson E,Weber KS,Bridgewater LC

11-0041-82 was used in Flow Cytometry to suggest that the recently described nuclear variant of BMP2 is necessary for efficient secondary immune responses.

Mon Aug 01 00:00:00 EDT 2016

Injectable cryogel-based whole-cell cancer vaccines.

Nature communications

Bencherif SA,Warren Sands R,Ali OA,Li WA,Lewin SA,Braschler TM,Shih TY,Verbeke CS,Bhatta D,Dranoff G,Mooney DJ

11-0041 was used in Flow cytometry/Cell sorting to investigate cancer vaccines based on injectable whole-cell cryogels.

Wed Aug 12 00:00:00 EDT 2015

BTLA associates with increased Foxp3 expression in CD4(+) T cells in dextran sulfate sodium-induced colitis.

International journal of clinical and experimental pathology

Zhang HX,Zhu B,Fu XX,Zeng JC,Zhang JA,Wang WD,Kong B,Xiang WY,Zhong J,Wang CY,Zheng XB,Xu JF

11-0041 was used in Immunofluorescence to determine that BTLA may be involved in the control of inflammatory responses through increasing Foxp3 expression in DSS-induced colitis.

Tue Mar 01 00:00:00 EST 2016

BTLA associates with increased Foxp3 expression in CD4(+) T cells in dextran sulfate sodium-induced colitis.

International journal of clinical and experimental pathology

Zhang HX,Zhu B,Fu XX,Zeng JC,Zhang JA,Wang WD,Kong B,Xiang WY,Zhong J,Wang CY,Zheng XB,Xu JF

11-0041 was used in Immunofluorescence to determine that BTLA may be involved in the control of inflammatory responses through increasing Foxp3 expression in DSS-induced colitis.

Tue Mar 01 00:00:00 EST 2016

CD11c(hi) Dendritic Cells Regulate Ly-6C(hi) Monocyte Differentiation to Preserve Immune-privileged CNS in Lethal Neuroinflammation.

Scientific reports

Kim JH,Choi JY,Kim SB,Uyangaa E,Patil AM,Han YW,Park SY,Lee JH,Kim K,Eo SK

11-0041 was used in Flow cytometry/Cell sorting to define the contribution of DCs to T cell-independent innate defence in immune-privileged CNS upon infection with neurotropic viruses.

Wed Dec 02 00:00:00 EST 2015

Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion.

The Journal of biological chemistry

Pamir N,Liu NC,Irwin A,Becker L,Peng Y,Ronsein GE,Bornfeldt KE,Duffield JS,Heinecke JW

11-0041 was used in Flow cytometry/Cell sorting to investigate dendritic cells and show cells that are dependent on GM-CSF restrain lean adipose tissue expansion.

Fri Jun 05 00:00:00 EDT 2015

Role of T-cell reconstitution in HIV-1 antiretroviral therapy-induced bone loss.

Nature communications

Ofotokun I,Titanji K,Vikulina T,Roser-Page S,Yamaguchi M,Zayzafoon M,Williams IR,Weitzmann MN

11-0041 was used in Flow cytometry/Cell sorting to suggest T-cell repopulation and/or immune reconstitution as putative mechanisms for bone loss following ART initiation.

Tue Sep 22 00:00:00 EDT 2015

Mannan-modified adenovirus targeting TERT and VEGFR-2: A universal tumour vaccine.

Scientific reports

Wang Y,Zhang J,Wu Y,Ding ZY,Luo XM,Liu J,Zhong WN,Deng GH,Xia XY,Deng YT,Wei YQ,Jiang Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Jun 18 00:00:00 EDT 2015

Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.

Cell transplantation

Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Nov 16 00:00:00 EST 2015

Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.

Cell transplantation

Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Nov 16 00:00:00 EST 2015

Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents.

Scientific reports

Guo A,He D,Xu HB,Geng CA,Zhao J

11-0041 was used in Flow cytometry/Cell sorting to study how the promotion of regulatory T cell induction could be an underlying mechanism of the herbal medicine licorice.

Tue Sep 15 00:00:00 EDT 2015

Intranasal Administration of Lentiviral miR-135a Regulates Mast Cell and Allergen-Induced Inflammation by Targeting GATA-3.

PloS one

Deng YQ,Yang YQ,Wang SB,Li F,Liu MZ,Hua QQ,Tao ZZ

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue May 31 00:00:00 EDT 2016

H9N2 influenza whole inactivated virus combined with polyethyleneimine strongly enhances mucosal and systemic immunity after intranasal immunization in mice.

Clinical and vaccine immunology : CVI

Qin T,Yin Y,Huang L,Yu Q,Yang Q

11-0041 was used in Flow cytometry/Cell sorting to investigate the immune activity of polyethyleneimine with H9N2 influenza whole inactivated virus, showing that it enhances mucosal and systemic immunity after intranasal immunization.

Wed Apr 01 00:00:00 EDT 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Sep 15 00:00:00 EDT 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Sep 15 00:00:00 EDT 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Sep 15 00:00:00 EDT 2015

Controlling immune rejection is a fail-safe system against potential tumorigenicity after human iPSC-derived neural stem cell transplantation.

PloS one

Itakura G,Kobayashi Y,Nishimura S,Iwai H,Takano M,Iwanami A,Toyama Y,Okano H,Nakamura M

11-0041 was used in Flow cytometry/Cell sorting to determine the feasibility of ablation of the tumors formed after hiPSC-NS/PC transplantation through immunoregulation.

Tue Dec 01 00:00:00 EST 2015

Effects of Feijining Decoction on vascular endothelial growth factor protein expression and changes of T cell subsets in Lewis lung carcinoma-bearing mice.

Biomedical reports

Zhou L,Pan Y,Xing Y,Gao H,Xie X,Yin D

11-0041 was used in Flow cytometry/Cell sorting to investigate the effects of Feijining Decoction (FJND) on VEGF protein expression and T-cell subsets in Lewis lung cancer bearing mice, showing that mice treated with FJND had significantly reduced VEGF and increased splenic CD4(+) and CD4(+)/CD8(+), suggesting that FJND can inhibit tumour growth.

Fri May 01 00:00:00 EDT 2015

Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses.

Stem cell reports

Wang WB,Yen ML,Liu KJ,Hsu PJ,Lin MH,Chen PM,Sudhir PR,Chen CH,Chen CH,Sytwu HK,Yen BL

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Sep 08 00:00:00 EDT 2015

DC targeting DNA vaccines induce protective and therapeutic antitumor immunity in mice.

International journal of clinical and experimental medicine

Wang Q,Cao W,Yang ZG,Zhao GF

11-0041 was used in Magnetic cell separation to show that DNA vaccine which targeting of dendritic cells in situ by the means of antibody-antigen conjugates may be a novel way to induce long-lasting antitumor immunity.

Fri Jan 15 00:00:00 EST 2016

Immunoglobulin E plays an immunoregulatory role in lupus.

The Journal of experimental medicine

Dema B,Charles N,Pellefigues C,Ricks TK,Suzuki R,Jiang C,Scheffel J,Hasni S,Hoffman V,Jablonski M,Sacré K,Gobert D,Papo T,Daugas E,Crampton S,Bolland S,Rivera J

11-0041 was used in Flow cytometry/Cell sorting to explore the effect of IgE deficiency on the inflammatory response in FcγRIIB-deficient mice, which hastens and results in a more aggressive lupuslike disease.

Mon Oct 20 00:00:00 EDT 2014

Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.

Autophagy

Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Jul 01 00:00:00 EDT 2014

CX3CR1⁺ cells facilitate the activation of CD4 T cells in the colonic lamina propria during antigen-driven colitis.

Mucosal immunology

Rossini V,Zhurina D,Radulovic K,Manta C,Walther P,Riedel CU,Niess JH

11-0041 was used in Flow cytometry/Cell sorting to study immune cell communication during the development of transfer colitis.

Thu May 01 00:00:00 EDT 2014

Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.

PLoS pathogens

Ataide MA,Andrade WA,Zamboni DS,Wang D,Souza Mdo C,Franklin BS,Elian S,Martins FS,Pereira D,Reed G,Fitzgerald KA,Golenbock DT,Gazzinelli RT

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2014

Low-dose 5-aza-2'-deoxycytidine pretreatment inhibits experimental autoimmune encephalomyelitis by induction of regulatory T cells.

Molecular medicine (Cambridge, Mass.)

Chan MW,Chang CB,Tung CH,Sun J,Suen JL,Wu SF

11-0041 was used in Flow cytometry/Cell sorting to investigate whether loss of P53 function contributes to persistent activation of STAT3 and modification of the pancreatic tumor stroma.

Thu Jun 26 00:00:00 EDT 2014

Wnt5a regulates hematopoietic stem cell proliferation and repopulation through the Ryk receptor.

Stem cells (Dayton, Ohio)

Povinelli BJ,Nemeth MJ

11-0041 was used in Immunocytochemistry to study whether Ryk protein regulates the response of haematopoietic stem cells to Wnt5a.

Wed Jan 01 00:00:00 EST 2014

Hepatic stellate cells promote tumor progression by enhancement of immunosuppressive cells in an orthotopic liver tumor mouse model.

Laboratory investigation; a journal of technical methods and pathology

Zhao W,Zhang L,Xu Y,Zhang Z,Ren G,Tang K,Kuang P,Zhao B,Yin Z,Wang X

11-0041 was used in Flow cytometry/Cell sorting to study the complex tumor-host interactions in hepatocellular carcinoma, specifically how the immunosuppressive properties of hepatic stellate cells may contribute to hepatocellular carcinoma occurrence and development..

Sat Feb 01 00:00:00 EST 2014

CD1d(hi)CD5+ B cells expanded by GM-CSF in vivo suppress experimental autoimmune myasthenia gravis.

Journal of immunology (Baltimore, Md. : 1950)

Sheng JR,Quan S,Soliven B

11-0041 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the tolorogenic effects of B10 cells in Experimental Autoimmune Myasthenia Gravis.

Mon Sep 15 00:00:00 EDT 2014

Innate PI3K p110δ regulates Th1/Th17 development and microbiota-dependent colitis.

Journal of immunology (Baltimore, Md. : 1950)

Steinbach EC,Kobayashi T,Russo SM,Sheikh SZ,Gipson GR,Kennedy ST,Uno JK,Mishima Y,Borst LB,Liu B,Herfarth H,Ting JP,Sartor RB,Plevy SE

11-0041 was used in Flow cytometry/Cell sorting to explore the role of IL-10 and IL-12/23 in the development of microbiota-dependent colitis.

Tue Apr 15 00:00:00 EDT 2014

Oral combined therapy with probiotics and alloantigen induces B cell-dependent long-lasting specific tolerance.

Journal of immunology (Baltimore, Md. : 1950)

Mercadante AC,Perobelli SM,Alves AP,Gonçalves-Silva T,Mello W,Gomes-Santos AC,Miyoshi A,Azevedo V,Faria AM,Bonomo A

11-0041 was used in Flow cytometry/Cell sorting to suggest that combined therapy is a promising strategy for prevention of GVHD with preservation of graft-versus-leukemia in allogenic HSCT.

Sat Feb 15 00:00:00 EST 2014

Tryptophan catabolism restricts IFN-γ-expressing neutrophils and Clostridium difficile immunopathology.

Journal of immunology (Baltimore, Md. : 1950)

El-Zaatari M,Chang YM,Zhang M,Franz M,Shreiner A,McDermott AJ,van der Sluijs KF,Lutter R,Grasberger H,Kamada N,Young VB,Huffnagle GB,Kao JY

11-0041 was used in Flow cytometry/Cell sorting to show tryptophan catabolism restricts IGN-gamma expressing neutrophils and Clostridium difficile immunopathology.

Tue Jul 15 00:00:00 EDT 2014

Regulation of cyp26a1 on Th17 cells in mouse peri-implantation.

Journal of cellular and molecular medicine

Liu HY,Chao H,Liu ZK,Xia HF,Song Z,Yang Y,Peng JP

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Sat Mar 01 00:00:00 EST 2014

The Serine Protease Inhibitor, 4-(2-aminoethyl) Benzene Sulfonyl Fluoride Hydrochloride, Reduces Allergic Inflammation in a House Dust Mite Allergic Rhinitis Mouse Model.

Allergy, asthma & immunology research

Kim BY,Park HR,Shin JH,Kim SW,Cho JH,Park YJ,Kim SW

11-0041 was used in Flow cytometry/Cell sorting to investigate the applications of the serine protease inhibitor 4-(2-aminoethyl) benzene sulfonyl fluoride hydrochloride in a mouse model of allergic rhinitis.

Sat Nov 01 00:00:00 EDT 2014

Tumor-promoting role of TGFβ1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells.

Carcinogenesis

Ravindran A,Mohammed J,Gunderson AJ,Cui X,Glick AB

11-0041 was used in Flow cytometry/Cell sorting to study how TGFβ1 signalling has a tumour-promoting role in UVB-induced skin carcinogenesis, which is mediated in part through its role in UVB-induced migration of dDC and cutaneous inflammation.

Tue Apr 01 00:00:00 EDT 2014

Increased Th17 cells in flow cytometer-sorted CD45RO-positive memory CD4 T cells from patients with systemic lupus erythematosus.

Lupus science & medicine

Liu MF,Wang CR

11-0041 was used in Flow cytometry/Cell sorting to show that increased frequencies of Th17 cells positively correlate with disease activity and proteinuria in SLE patients, confirming the dysregulation of Th17/IL-17 in SLE.

Thu Jan 01 00:00:00 EST 2015

Immunomodulatory effects of polysaccharide from marine fungus Phoma herbarum YS4108 on T cells and dendritic cells.

Mediators of inflammation

Chen S,Ding R,Zhou Y,Zhang X,Zhu R,Gao XD

11-0041 was used in Flow cytometry/Cell sorting to investigate the immunomodulatory effects of polysaccharide from a marine fungus Phoma herbarum on T cells and dendritic cells.

Tue Sep 08 00:00:00 EDT 2015

Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.

Human vaccines & immunotherapeutics

Wang S,Wu B,Xue J,Wang M,Chen R,Wang B

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Jan 05 00:00:00 EST 2015

Enhancement of SIV-specific cell mediated immune responses by co-administration of soluble PD-1 and Tim-3 as molecular adjuvants in mice.

Human vaccines & immunotherapeutics

Xiao L,Wang D,Sun C,Li P,Jin Y,Feng L,Chen L

11-0041 was used in Flow cytometry/Cell sorting to study whether co-administration of sPD-1 and sTim-3 with an adenovirus vectored SIV vaccine (rAd5-SIV) can enhance cell mediated immune responses.

Mon Mar 30 00:00:00 EDT 2015

High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Somatostatin inhibits the production of interferon-γ by intestinal epithelial cells during intestinal ischemia-reperfusion in macaques.

Digestive diseases and sciences

Liu L,Tan Q,Hu B,Wu H,Wang C,Tang C

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunohistochemistry

Wed Oct 01 00:00:00 EDT 2014

Immune selection of tumor cells in TCR β-chain transgenic mice.

Journal of immunotoxicology

Silaeva YY,Grinenko TS,Vagida MS,Kalinina AA,Khromykh LM,Kazansky DB

11-0041 was used in Flow cytometry/Cell sorting to compare the ability of WT and transgenic, immune-compromised mice to reject EL4 thymoma cells.

Wed Oct 01 00:00:00 EDT 2014

Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects.

BMC cancer

Tian H,Shi G,Yang G,Zhang J,Li Y,Du T,Wang J,Xu F,Cheng L,Zhang X,Dai L,Chen X,Zhang S,Yang Y,Yu D,Wei Y,Deng H

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Jan 29 00:00:00 EST 2014

Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects.

BMC cancer

Tian H,Shi G,Yang G,Zhang J,Li Y,Du T,Wang J,Xu F,Cheng L,Zhang X,Dai L,Chen X,Zhang S,Yang Y,Yu D,Wei Y,Deng H

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Jan 29 00:00:00 EST 2014

A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking β-glucans.

PloS one

Dong B,Li D,Li R,Chen SC,Liu W,Liu W,Chen L,Chen Y,Zhang X,Tong Z,Xia Y,Xia P,Wang Y,Duan Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2015

Autophagy is a critical regulator of memory CD8(+) T cell formation.

eLife

Puleston DJ,Zhang H,Powell TJ,Lipina E,Sims S,Panse I,Watson AS,Cerundolo V,Townsend AR,Klenerman P,Simon AK

11-0041 was used in Flow cytometry/Cell sorting to show that mice lacking the autophagy gene Atg7 in T cells failed to establish CD8(+) T cell memory to influenza and MCMV infection.

Tue Nov 11 00:00:00 EST 2014

Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.

BMC biology

Reynolds C,Chong D,Raynsford E,Quigley K,Kelly D,Llewellyn-Hughes J,Altmann D,Boyton R

11-0041 was used in Flow cytometry/Cell sorting to study how the conformation of TCR alpha chain CDR3 favours different CD4 cytokine profiles.

Fri May 09 00:00:00 EDT 2014

Simultaneous inhibition of T helper 2 and T regulatory cell differentiation by small molecules enhances Bacillus Calmette-Guerin vaccine efficacy against tuberculosis.

The Journal of biological chemistry

Bhattacharya D,Dwivedi VP,Kumar S,Reddy MC,Van Kaer L,Moodley P,Das G

11-0041 was used in Flow cytometry/Cell sorting to study the inhibition of Th2 cells and Tregs and the subsequent enhancement of the BCG vaccine efficacy.

Fri Nov 28 00:00:00 EST 2014

ASK1 promotes the contact hypersensitivity response through IL-17 production.

Scientific reports

Mizukami J,Sato T,Camps M,Ji H,Rueckle T,Swinnen D,Tsuboi R,Takeda K,Ichijo H

11-0041 was used in Flow cytometry/Cell sorting to study the role of ASK1 in the contact hypersensitivity response.

Wed Apr 16 00:00:00 EDT 2014

Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation.

PloS one

Carty SA,Koretzky GA,Jordan MS

11-0041 was used in Flow cytometry/Cell sorting to investigate the signaling pathways required for IL-4 induction of Eomes and CD8(+) innate-like lymphocyte markers in murine CD8SP thymocytes and peripheral CD8(+) T cells.

Thu May 21 00:00:00 EDT 2015

Small molecule-directed immunotherapy against recurrent infection by Mycobacterium tuberculosis.

The Journal of biological chemistry

Bhattacharya D,Dwivedi VP,Maiga M,Maiga M,Van Kaer L,Bishai WR,Das G

11-0041 was used in Flow cytometry/Cell sorting to investigate small molecule-directed immunotherapy against Th2 and regulatory T cell subsets to reduce recurrent Mycobacterium tuberculosis infection and drug resistance.

Fri Jun 06 00:00:00 EDT 2014

Interleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under Interleukin-2 deprivation conditions.

PloS one

Khattar M,Miyahara Y,Schroder PM,Xie A,Chen W,Stepkowski SM

11-0041 was used in Flow cytometry/Cell sorting to investigate the role of IL-2 during early events of T cell activation, showing that IL-21 is a critical regulator of T cell survival during priming under IL-2 deprivation.

Mon Sep 08 00:00:00 EDT 2014

An orally active immune adjuvant prepared from cones of Pinus sylvestris, enhances the proliferative phase of a primary T cell response.

BMC complementary and alternative medicine

Bradley WG,Holm KN,Tanaka A

11-0041 was used in Flow cytometry/Cell sorting to investigate the mechanism by which polyphenylpropanoid polysaccharide complex enhances the proliferative phase of a primary T cell response.

Thu May 22 00:00:00 EDT 2014

Isoniazid induces apoptosis of activated CD4+ T cells: implications for post-therapy tuberculosis reactivation and reinfection.

The Journal of biological chemistry

Tousif S,Singh DK,Ahmad S,Moodley P,Bhattacharyya M,Van Kaer L,Das G

11-0041 was used in Flow cytometry/Cell sorting to show that Isoniazid treatment of Mycobacterium tuberculosis treatment is associated with immune impairment.

Fri Oct 31 00:00:00 EDT 2014

Differential potency of regulatory T cell-mediated immunosuppression in kidney tumors compared to subcutaneous tumors.

Oncoimmunology

Devaud C,Westwood JA,Teng MW,John LB,Yong CS,Duong CP,Smyth MJ,Darcy PK,Kershaw MH

11-0041 was used in Flow cytometry/Cell sorting to provide insights into the immunosuppressive nature of the immune response generated in the kidney microenvironment.

Sat Nov 01 00:00:00 EDT 2014

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells.

Nature immunology

Pierson W,Cauwe B,Policheni A,Schlenner SM,Franckaert D,Berges J,Humblet-Baron S,Schönefeldt S,Herold MJ,Hildeman D,Strasser A,Bouillet P,Lu LF,Matthys P,Freitas AA,Luther RJ,Weaver CT,Dooley J,Gray DH,Liston A

11-0041 was used in Flow cytometry/Cell sorting to study the regulation of the Foxp3+ T cell pool by proliferation and apoptosis, and specifically the role of antiapoptoic Mcl-1 in T cell survival.

Sun Sep 01 00:00:00 EDT 2013

Emotional change-associated T cell mobilization at the early stage of a mouse model of multiple sclerosis.

Frontiers in immunology

Piras G,Rattazzi L,McDermott A,Deacon R,D'Acquisto F

11-0041 was used in Flow cytometry/Cell sorting to explore a possible correlation between T cell activation and changes in emotional behavior in a multiple sclerosis mouse model.

Fri Dec 06 00:00:00 EST 2013

Intravaginal TLR agonists increase local vaccine-specific CD8 T cells and human papillomavirus-associated genital-tumor regression in mice.

Mucosal immunology

Domingos-Pereira S,Decrausaz L,Derré L,Bobst M,Romero P,Schiller JT,Jichlinski P,Nardelli-Haefliger D

11-0041 was used in Flow cytometry/Cell sorting to study the immune effects of the instillation of Toll-like receptor agonists after subcutaneous E7 vaccination.

Fri Mar 01 00:00:00 EST 2013

TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity.

The Journal of investigative dermatology

Mohammed J,Gunderson AJ,Khong HH,Koubek RD,Udey MC,Glick AB

11-0041 was used in Flow cytometry/Cell sorting to highlight a role for keratinocyte-derived TGFβ1 in dendritic cell trafficking and in the initiation of skin inflammation.

Tue Jan 01 00:00:00 EST 2013

Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.

Development (Cambridge, England)

Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2013

Intrinsic T- and B-cell defects impair T-cell-dependent antibody responses in mice lacking the actin-bundling protein L-plastin.

European journal of immunology

Todd EM,Deady LE,Morley SC

11-0041 was used in Flow cytometry/Cell sorting to study the role of L-plastin in the modulation of both T- and B-cell immune responses.

Mon Jul 01 00:00:00 EDT 2013

Enhanced autoimmunity associated with induction of tumor immunity in thyroiditis-susceptible mice.

Thyroid : official journal of the American Thyroid Association

Kari S,Flynn JC,Zulfiqar M,Snower DP,Elliott BE,Kong YC

11-0041 was used in Flow cytometry/Cell sorting to indicate that genetic predisposition to autoimmune disease could enhance autoimmunity during induction of tumor immunity in thyroiditis-susceptible mice.

Sun Dec 01 00:00:00 EST 2013

A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).

Disease models & mechanisms

Carofino BL,Ayanga B,Justice MJ

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Nov 01 00:00:00 EDT 2013

Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice.

Human vaccines & immunotherapeutics

Wu B,Zou Q,Hu Y,Wang B

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2013

The crosstalk: Tumor-infiltrating lymphocytes rich in regulatory T cells suppressed cancer-associated fibroblasts.

Acta oncologica (Stockholm, Sweden)

Fu Z,Zuo Y,Li D,Xu W,Li D,Chen H,Zheng S

11-0041 was used in Flow cytometry/Cell sorting to investigate the suppression of CAFs and NFs by Tregs-rich TILs.

Fri Nov 01 00:00:00 EDT 2013

An increased number of CD4+CD25+ cells induced by an oral administration of Lactobacillus plantarum NRIC0380 are involved in antiallergic activity.

International archives of allergy and immunology

Yoshida T,Fujiwara W,Enomoto M,Nakayama S,Matsuda H,Sugiyama H,Shimojoh M,Okada S,Hattori M

11-0041 was used in Flow cytometry/Cell sorting to study how increased CD4+CD25+ cells are involved in antiallergic activity.

Fri Feb 07 00:00:00 EST 2014

No immunogenicity of IPS cells in syngeneic host studied by in vivo injection and 3D scaffold experiments.

BioMed research international

Thanasegaran S,Cheng Z,Ito S,Nishio N,Isobe K

11-0041 was used in Immunohistochemistry to investigate the change in iPSC density inside a three-dimensional porous scaffold transplanted into sygeneic and allogeneic mice.

Wed Dec 04 00:00:00 EST 2013

The role of IL-2 in the activation and expansion of regulatory T-cells and the development of experimental autoimmune encephalomyelitis.

Immunobiology

Rouse M,Nagarkatti M,Nagarkatti PS

11-0041 was used in Flow cytometry/Cell sorting to investigate the effect of administration of IL-2 on the development of EAE, showing that pre-treatment causes significant amelioration of EAE.

Mon Apr 01 00:00:00 EDT 2013

Enhanced immune response against HIV-1 induced by a heterologous DNA prime-adenovirus boost vaccination using mannosylated polyethyleneimine as DNA vaccine adjuvant.

International journal of nanomedicine

Li M,Jiang Y,Xu C,Zhang Z,Sun X

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Wed Apr 02 00:00:00 EDT 2014

Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.

PloS one

Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Jul 31 00:00:00 EDT 2014

Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.

The Journal of biological chemistry

Steelman AJ,Smith R,Welsh CJ,Li J

11-0041 was used in Flow cytometry/Cell sorting to investigate the role of galectin-9 in the pathogenesis of multiple sclerosis.

Fri Aug 16 00:00:00 EDT 2013

DNA vaccines targeting the encoded antigens to dendritic cells induce potent antitumor immunity in mice.

BMC immunology

Cao J,Jin Y,Li W,Zhang B,He Y,Liu H,Xia N,Wei H,Yan J

11-0041 was used in Flow cytometry/Cell sorting to investigate anti-tumoural efficacy and underlying mechanisms of DC-targeting DNA vaccines in mouse breast cancer models, showing that it induces potent anti-tumour immunity in mice.

Wed Aug 14 00:00:00 EDT 2013

Thymic stromal lymphopoietin attenuates the development of atherosclerosis in ApoE-/- mice.

Journal of the American Heart Association

Yu K,Zhu P,Dong Q,Zhong Y,Zhu Z,Lin Y,Huang Y,Meng K,Ji Q,Yi G,Zhang W,Wu B,Mao Y,Cheng P,Zhao X,Mao X,Zeng Q

11-0041 was used in Flow cytometry/Cell sorting to examine the phenotype of TSLP-conditioned bone marrow dendritic cells of apolipoprotein E-deficient mice and their capacity to induce the differentiation of Tregs.

Wed Aug 28 00:00:00 EDT 2013

Roscovitine suppresses CD4+ T cells and T cell-mediated experimental uveitis.

PloS one

Zhang Z,Liu Q,Leskov KS,Wu X,Duan J,Zhang GL,Hall M,Rosenbaum JT

11-0041 was used in Flow cytometry/Cell sorting to test the immunosuppressive effect of roscovitine, a potent CdK2 inhibitor, on CD4+ T cell activation, proliferation, and function.

Mon Jun 30 00:00:00 EDT 2014

CD4⁺ but not CD8⁺ T cells revert the impaired emotional behavior of immunocompromised RAG-1-deficient mice.

Translational psychiatry

Rattazzi L,Piras G,Ono M,Deacon R,Pariante CM,D'Acquisto F

11-0041 was used in Flow cytometry/Cell sorting to understand the mechanisms linking an immunocompromised state to a variety of mood disorders.

Tue Jul 09 00:00:00 EDT 2013

Resistance to malaria by enhanced phagocytosis of erythrocytes in LMP7-deficient mice.

PloS one

Duan X,Imai T,Chou B,Tu L,Himeno K,Suzue K,Hirai M,Taniguchi T,Okada H,Shimokawa C,Hisaeda H

11-0041 was used in Flow cytometry/Cell sorting to study how RBCs of LMP7-deficient mice were more likely to deform in response to infection with malaria parasites.

Tue Sep 17 00:00:00 EDT 2013

Partial depletion of regulatory T cells does not influence the inflammation caused by high dose hemi-body irradiation.

PloS one

Ma S,Richardson JA,Bitmansour A,Solberg TD,Pidikiti R,Song K,Stojadinovic S,Vitetta ES,Meyer JJ

11-0041 was used in Flow cytometry/Cell sorting to investigate the effects of partial depletion of regulatory T cells alongside ionizing radiation on inflammation and tissue injury in mice.

Mon Jul 29 00:00:00 EDT 2013

Lack of endogenous IL-10 enhances production of proinflammatory cytokines and leads to Brucella abortus clearance in mice.

PloS one

Corsetti PP,de Almeida LA,Carvalho NB,Azevedo V,Silva TM,Teixeira HC,Faria AC,Oliveira SC

11-0041 was used in Flow cytometry/Cell sorting to evaluate the contribution of IL-10 in host immune response and pathology during B. abortus infection.

Sun Jun 15 00:00:00 EDT 2014

The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine.

PloS one

Radulovic K,Rossini V,Manta C,Holzmann K,Kestler HA,Niess JH

11-0041 was used in Flow cytometry/Cell sorting to show CD69 is a negative regulator of inflammatory responses in the intestine, reducing the accumulation of CD4 T cells in cLP during colitis.

Thu Jan 23 00:00:00 EST 2014

The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine.

PloS one

Radulovic K,Rossini V,Manta C,Holzmann K,Kestler HA,Niess JH

11-0041 was used in Flow cytometry/Cell sorting to show CD69 is a negative regulator of inflammatory responses in the intestine, reducing the accumulation of CD4 T cells in cLP during colitis.

Thu Jan 23 00:00:00 EST 2014

Transient combination therapy targeting the immune synapse abrogates T cell responses and prolongs allograft survival in mice.

PloS one

Schroder PM,Khattar M,Deng R,Xie A,Chen W,Stepkowski SM

11-0041 was used in Flow cytometry/Cell sorting to study the effect of transient anti-TCRB and anti-LFA1 mAb combination therapy on T cell responses and prolonged allograft survival in mice.

Thu Feb 20 00:00:00 EST 2014

Angiotensin II is a new component involved in splenic T lymphocyte responses during Plasmodium berghei ANKA infection.

PloS one

Silva-Filho JL,Souza MC,Ferreira-Dasilva CT,Silva LS,Costa MF,Padua TA,Henriques Md,Morrot A,Savino W,Caruso-Neves C,Pinheiro AA

11-0041 was used in Flow cytometry/Cell sorting to provide evidence for the potential role of Ang II in regulating the splenic immune response.

Tue Nov 26 00:00:00 EST 2013

Transcription factor RORα is critical for nuocyte development.

Nature immunology

Wong SH,Walker JA,Jolin HE,Drynan LF,Hams E,Camelo A,Barlow JL,Neill DR,Panova V,Koch U,Radtke F,Hardman CS,Hwang YY,Fallon PG,McKenzie AN

11-0041 was used in Flow cytometry/Cell sorting to study how nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, indicating they are a distinct, previously unknown member of the lymphoid lineage.

Sun Jan 22 00:00:00 EST 2012

Concomitant inactivation of Rb and E2f8 in hematopoietic stem cells synergizes to induce severe anemia.

Blood

Hu T,Ghazaryan S,Sy C,Wiedmeyer C,Chang V,Wu L

11-0041 was used in Flow cytometry/Cell sorting to reveal the specificity of E2F8 in mediating Rb function in erythropoiesis.

Thu May 10 00:00:00 EDT 2012

Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity.

The Journal of clinical investigation

Johnson KD,Hsu AP,Ryu MJ,Wang J,Gao X,Boyer ME,Liu Y,Lee Y,Calvo KR,Keles S,Zhang J,Holland SM,Bresnick EH

11-0041 was used in Flow cytometry/Cell sorting to identify a novel mutation in a GATA2 cis-element which causes deficits in haematopoietic stem/progenitor activity.

Mon Oct 01 00:00:00 EDT 2012

Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.

Oncogene

Darlington Y,Nguyen TA,Moon SH,Herron A,Rao P,Zhu C,Lu X,Donehower LA

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Mar 01 00:00:00 EST 2012

Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue.

The Journal of infectious diseases

Angin M,Kwon DS,Streeck H,Wen F,King M,Rezai A,Law K,Hongo TC,Pyo A,Piechocka-Trocha A,Toth I,Pereyra F,Ghebremichael M,Rodig SJ,Milner DA,Richter JM,Altfeld M,Kaufmann DE,Walker BD,Addo MM

11-0041 was used in Flow cytometry/Cell sorting to study the frequency and function of Tregs in HIV-1-infected individuals.

Tue May 15 00:00:00 EDT 2012

CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential.

Journal of immunology (Baltimore, Md. : 1950)

Radulovic K,Manta C,Rossini V,Holzmann K,Kestler HA,Wegenka UM,Nakayama T,Niess JH

11-0041 was used in Flow cytometry/Cell sorting to demonstrate that CD69 knockout can modulate mucosal CD4 T cells and increase colitis levels in a mouse transfer model of the disease.

Wed Feb 15 00:00:00 EST 2012

Arsenic trioxide exerts antitumor activity through regulatory T cell depletion mediated by oxidative stress in a murine model of colon cancer.

Journal of immunology (Baltimore, Md. : 1950)

Thomas-Schoemann A,Batteux F,Mongaret C,Nicco C,Chéreau C,Annereau M,Dauphin A,Goldwasser F,Weill B,Lemare F,Alexandre J

11-0041 was used in Flow cytometry/Cell sorting to examine the potential for As(2)O(3) to enhance adoptive immunotherapy strategies in human cancer.

Sat Dec 01 00:00:00 EST 2012

Mannose-capped lipoarabinomannan from Mycobacterium tuberculosis preferentially inhibits sphingosine-1-phosphate-induced migration of Th1 cells.

Journal of immunology (Baltimore, Md. : 1950)

Richmond JM,Lee J,Green DS,Kornfeld H,Cruikshank WW

11-0041 was used in Flow cytometry/Cell sorting to examine the ability of ManLAM to desensitize T cells to other chemoattractants during mycobacterial infection.

Sat Dec 15 00:00:00 EST 2012

A critical role for Rictor in T lymphopoiesis.

Journal of immunology (Baltimore, Md. : 1950)

Tang F,Wu Q,Ikenoue T,Guan KL,Liu Y,Zheng P

11-0041 was used in Flow cytometry/Cell sorting to investigate the signalling pathway required for T lymphopoiesis, showing a critical role for Rictor.

Wed Aug 15 00:00:00 EDT 2012

Identification of a selective RORγ ligand that suppresses T(H)17 cells and stimulates T regulatory cells.

ACS chemical biology

Solt LA,Kumar N,He Y,Kamenecka TM,Griffin PR,Burris TP

11-0041 was used in Flow cytometry/Cell sorting to evaluate the specificity of a synthetic compound for RORγ and its effects on Th17 and Treg cell development.

Fri Sep 21 00:00:00 EDT 2012

In vivo two-photon imaging of T cell motility in joint-draining lymph nodes in a mouse model of rheumatoid arthritis.

Cellular immunology

Kobezda T,Ghassemi-Nejad S,Glant TT,Mikecz K

11-0041 was used in Flow cytometry/Cell sorting to examine whether lymph node T cells reduce their motility upon contact with relevant antigen-presenting cells in WT mice.

Mon Jan 07 00:00:00 EST 2013

MyD88-dependent recruitment of monocytes and dendritic cells required for protection from pulmonary Burkholderia mallei infection.

Infection and immunity

Goodyear A,Troyer R,Bielefeldt-Ohmann H,Dow S

11-0041 was used in Flow cytometry/Cell sorting to find that MyD88-/- mice were highly susceptible to pulmonary challenge with B. mallei and had significantly short survival times, increased bacterial burdens, and severe organ pathology compared to wild-type mice.

Sun Jan 01 00:00:00 EST 2012

Resveratrol analogue HS-1793 induces the modulation of tumor-derived T cells.

Experimental and therapeutic medicine

Choi YJ,Yang KM,Kim SD,Yoo YH,Lee SW,Seo SY,Suh H,Yee ST,Jeong MH,Jo WS

11-0041 was used in Flow cytometry/Cell sorting to reveal the suppressive effect HS-1793 has on Treg cells, and its likely contribution to tumor-specific cytotoxic T lymphocyte responses.

Sun Apr 01 00:00:00 EDT 2012

Interleukin-7 influences FOXP3+CD4+ regulatory T cells peripheral homeostasis.

PloS one

Simonetta F,Gestermann N,Martinet KZ,Boniotto M,Tissières P,Seddon B,Bourgeois C

11-0041 was used in Flow cytometry/Cell sorting to elucidate the mechanisms governing Treg cell survival and homeostasis.

Wed Sep 26 00:00:00 EDT 2012

Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.

PloS one

Gong Y,Wang Z,Liang Z,Duan H,Ouyang L,Yu Q,Xu Z,Shen G,Weng X,Wu X

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Fri Jul 19 00:00:00 EDT 2013

Granulocytes and vascularization regulate uterine bleeding and tissue remodeling in a mouse menstruation model.

PloS one

Menning A,Walter A,Rudolph M,Gashaw I,Fritzemeier KH,Roese L

11-0041 was used in Flow cytometry/Cell sorting to investigate mechanisms underlying pathogenesis of menstrual disorders, showing that granulocytes and vascularisation regulate uterine bleeding and tissue remodelling.

Thu Jan 10 00:00:00 EST 2013

Flt3L combined with rapamycin promotes cardiac allograft tolerance by inducing regulatory dendritic cells and allograft autophagy in mice.

PloS one

Xiong A,Duan L,Chen J,Fan Z,Zheng F,Tan Z,Gong F,Fang M

11-0041 was used in Flow cytometry/Cell sorting to investigate the role of Flt3 and Flt3L in immune tolerance, showing that Flt3L combined with rapamycin promotes cardiac allograft tolerance via dendritic cell induction.

Tue Jun 11 00:00:00 EDT 2013

MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1.

PloS one

Yao R,Ma YL,Liang W,Li HH,Ma ZJ,Yu X,Liao YH

11-0041 was used in Flow cytometry/Cell sorting to investigate the role of miR-155 in the mechanisms involved in CD4(+) CD25(+) regulatory T (Treg)/T helper (Th)17 cell differentiation and function.

Thu Mar 28 00:00:00 EDT 2013

RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.

Immunity

Powolny-Budnicka I,Riemann M,Tänzer S,Schmid RM,Hehlgans T,Weih F

11-0041 was used in Flow cytometry/Cell sorting to investigate the contribution of NF-κB to IL-17 production by T cells, showing that RelA and RelB in distinct thymocyte populations control lymphotoxin-dependent IL-17 production.

Fri Mar 25 00:00:00 EDT 2011

Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle.

Molecular medicine (Cambridge, Mass.)

Eghtesad S,Jhunjhunwala S,Little SR,Clemens PR

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunohistochemistry

Sun Mar 25 00:00:00 EDT 2012

Inferring relevant control mechanisms for interleukin-12 signaling in naïve CD4+ T cells.

Immunology and cell biology

Finley SD,Gupta D,Cheng N,Klinke DJ

11-0041 was used in Flow cytometry/Cell sorting to infer the relative importance of regulatory mechanisms that modulate the activation of STAT4 in naive CD4(+) T cells.

Sat Jan 01 00:00:00 EST 2011

T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.

Journal of immunology (Baltimore, Md. : 1950)

Wang R,Xie H,Huang Z,Ma J,Fang X,Ding Y,Sun Z

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2011

Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility.

Journal of immunology (Baltimore, Md. : 1950)

Kondilis-Mangum HD,Shih HY,Mahowald G,Sleckman BP,Krangel MS

11-0041 was used in Flow cytometry/Cell sorting to analyse the contributions of chromatin accessibility and locus conformation to feedback inhibition.

Thu Dec 15 00:00:00 EST 2011

Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.

Journal of immunology (Baltimore, Md. : 1950)

LaCasse CJ,Janikashvili N,Larmonier CB,Alizadeh D,Hanke N,Kartchner J,Situ E,Centuori S,Har-Noy M,Bonnotte B,Katsanis E,Larmonier N

11-0041 was used in Flow cytometry/Cell sorting to investigate the regulation of murine dendritic cell cytotoxic functions by T lymphocytes.

Thu Dec 15 00:00:00 EST 2011

Genetic variation determines mast cell functions in experimental asthma.

Journal of immunology (Baltimore, Md. : 1950)

Becker M,Reuter S,Friedrich P,Doener F,Michel A,Bopp T,Klein M,Schmitt E,Schild H,Radsak MP,Echtenacher B,Taube C,Stassen M

11-0041 was used in Flow cytometry/Cell sorting to investigate the role of mast cells in allergic asthma.

Wed Jun 15 00:00:00 EDT 2011

Regulation of experimental autoimmune uveoretinitis by anti-delta-like ligand 4 monoclonal antibody.

Investigative ophthalmology & visual science

Ishida W,Fukuda K,Sakamoto S,Koyama N,Koyanagi A,Yagita H,Fukushima A

11-0041 was used in Flow cytometry/Cell sorting to investigate the involvement of δ-like ligand (Dll)4 in the development of experimental autoimmune uveoretinitis in B10.RIII mice.

Mon Oct 17 00:00:00 EDT 2011

Toll-like receptor 9 is required for full host resistance to Mycobacterium avium infection but plays no role in induction of Th1 responses.

Infection and immunity

Carvalho NB,Oliveira FS,Durães FV,de Almeida LA,Flórido M,Prata LO,Caliari MV,Appelberg R,Oliveira SC

11-0041 was used in Flow cytometry/Cell sorting to investigate the role of Toll-like receptor 9 (TLR9) in innate immunity to Mycobacterium avium.

Fri Apr 01 00:00:00 EDT 2011

T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival.

PloS one

Moro H,Otero DC,Tanabe Y,David M

11-0041 was used in Flow cytometry/Cell sorting to demonstrate that type I interferons and STAT1 play an important role in the survival of MHC class I-restricted T cells.

Fri Feb 03 00:00:00 EST 2012

Multiple phenotypes in adult mice following inactivation of the Coxsackievirus and Adenovirus Receptor (Car) gene.

PloS one

Pazirandeh A,Sultana T,Mirza M,Rozell B,Hultenby K,Wallis K,Vennström B,Davis B,Arner A,Heuchel R,Löhr M,Philipson L,Sollerbrant K

11-0041 was used in Flow cytometry/Cell sorting to demonstrate that CAR exerts important functions in the physiology of several organs in vivo in mice.

Fri Sep 30 00:00:00 EDT 2011

C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells.

European journal of immunology

Weaver DJ,Reis ES,Pandey MK,Köhl G,Harris N,Gerard C,Köhl J

11-0041 was used in Flow cytometry/Cell sorting to demonstrate that C5aR signalling in DCs affects the development of immune cells.

Mon Mar 01 00:00:00 EST 2010

Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome.

European journal of immunology

Reimer T,Shaw MH,Franchi L,Coban C,Ishii KJ,Akira S,Horii T,Rodriguez A,Núñez G

11-0041 was used in Flow cytometry/Cell sorting to study the role of Nlrp3 in experimental cerebral malaria.

Mon Mar 01 00:00:00 EST 2010

Measles virus-induced immunosuppression in SLAM knock-in mice.

Journal of virology

Koga R,Ohno S,Ikegame S,Yanagi Y

11-0041 was used in Flow cytometry/Cell sorting to generate a model to investigate the mechanism by which the measles virus causes immunosuppression, showing that SLAM knock-in mice lacking the expression of the alpha/beta-interferon receptor could serve as a model.

Sat May 01 00:00:00 EDT 2010

Effective immunotherapy of weakly immunogenic solid tumours using a combined immunogene therapy and regulatory T-cell inactivation.

Cancer gene therapy

Whelan MC,Casey G,MacConmara M,Lederer JA,Soden D,Collins JK,Tangney M,O'Sullivan GC

11-0041 was used in Flow cytometry/Cell sorting to study the use of a combined immunogene therapy and regulatory T-cell inactivation against weakly immunogenic solid tumours.

Thu Jul 01 00:00:00 EDT 2010

The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract infection.

Journal of immunology (Baltimore, Md. : 1950)

Sivick KE,Schaller MA,Smith SN,Mobley HL

11-0041 was used in Flow cytometry/Cell sorting to show that IL-17A is a key mediator for the innate immune response to UTIs.

Mon Feb 15 00:00:00 EST 2010

CCR6 marks regulatory T cells as a colon-tropic, IL-10-producing phenotype.

Journal of immunology (Baltimore, Md. : 1950)

Kitamura K,Farber JM,Kelsall BL

11-0041 was used in Flow cytometry/Cell sorting to conclude that CCR6 expression on Treg cells was required for the full function of Treg cell-mediated suppression in a model of colitis.

Wed Sep 15 00:00:00 EDT 2010

IL-1-induced inflammation promotes development of leishmaniasis in susceptible BALB/c mice.

International immunology

Voronov E,Dotan S,Gayvoronsky L,White RM,Cohen I,Krelin Y,Benchetrit F,Elkabets M,Huszar M,El-On J,Apte RN

11-0041 was used in Flow cytometry/Cell sorting to assess the role of host derived IL-1 on the course of Leishmania major infection in susceptible BLAB/c mice.

Thu Apr 01 00:00:00 EDT 2010

Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity.

Gene therapy

Eghtesad S,Zheng H,Nakai H,Epperly MW,Clemens PR

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Immunohistochemistry

Wed Sep 01 00:00:00 EDT 2010

CCR7 deficiency leads to leukocyte activation and increased clearance in response to pulmonary Pseudomonas aeruginosa infection.

Infection and immunity

Eppert BL,Motz GT,Wortham BW,Flury JL,Borchers MT

11-0041 was used in Flow cytometry/Cell sorting to investigate the roles of CCR7 in the host defense against pulmonary infection, showing that CCR7 deficiency leads to leukocyte activation and increased infection clearance.

Sat May 01 00:00:00 EDT 2010

Efficient isolation of mouse liver NKT cells by perfusion.

PloS one

Fang X,Du P,Liu Y,Tang J

11-0041 was used in Flow cytometry/Cell sorting to develop a simple method to isolate NKT cells using perfusion, with similar yield to the traditional methods.

Wed Apr 21 00:00:00 EDT 2010

Flow cytometry analysis of transcription factors in T lymphocytes.

Methods in molecular biology (Clifton, N.J.)

Albu DI,Califano D,Avram D

11-0041 was used in Flow cytometry/Cell sorting to develop and optimise a protocol for the rapid and convenient detection of the transcription factor BCL11B in T lymphocyte subpopulations.

Tue Dec 28 00:00:00 EST 2010

Activation-induced T helper cell death contributes to Th1/Th2 polarization following murine Schistosoma japonicum infection.

Journal of biomedicine & biotechnology

Xu X,Wen X,Chi Y,He L,Zhou S,Wang X,Zhao J,Liu F,Su C

11-0041 was used in Flow cytometry/Cell sorting to suggest that Th1 or Th2 cell apoptosis is preferentially induced by different schistosome antigens during different stages of infection.

Thu Apr 01 00:00:00 EDT 2010

Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury.

Journal of the American Society of Nephrology : JASN

Kinsey GR,Sharma R,Huang L,Li L,Vergis AL,Ye H,Ju ST,Okusa MD

11-0041 was used in Flow cytometry/Cell sorting to investigate whether the anti-inflammatory effects of CD4(+)CD25(+)FoxP3(+) Tregs protect against renal IRI.

Sat Aug 01 00:00:00 EDT 2009

Naturally-existing CD4(+)CD25(+)Foxp3(+) regulatory T cells are required for tolerance to experimental autoimmune thyroiditis induced by either exogenous or endogenous autoantigen.

Journal of autoimmunity

Morris GP,Brown NK,Kong YC

11-0041 was used in Flow cytometry/Cell sorting to highlight the important role of Tregs in mediating self-tolerance in relation to experimental autoimmune thyroiditis.

Sat Aug 01 00:00:00 EDT 2009

The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies.

Cancer research

Ozao-Choy J,Ma G,Kao J,Wang GX,Meseck M,Sung M,Schwartz M,Divino CM,Pan PY,Chen SH

11-0041 was used in Flow cytometry/Cell sorting to suggest that sunitinib can be used to reverse immune suppression and as a potentially useful adjunct for enhancing the efficacy of immune-based cancer therapy for advanced malignancies.

Sun Mar 15 00:00:00 EDT 2009

Naringenin: a potential immunomodulator for inhibiting lung fibrosis and metastasis.

Cancer research

Du G,Jin L,Han X,Song Z,Zhang H,Liang W

11-0041 was used in Flow cytometry/Cell sorting to determine whether mouse models of idiopathic pulmonary fibrosis have high incidence of lung cancer, showing that Naringenin could treat lung fibrosis and metastasis.

Wed Apr 01 00:00:00 EDT 2009

Human CD8+CXCR3+ T cells have the same function as murine CD8+CD122+ Treg.

European journal of immunology

Shi Z,Okuno Y,Rifa'i M,Endharti AT,Akane K,Isobe K,Suzuki H

11-0041-82 was used in Flow Cytometry to suggest that human CD8(+)CXCR3(+) T cells are the counterparts of murine CD8(+)CD122(+) Treg.

Sat Aug 01 00:00:00 EDT 2009

Lymphocyte and antibody responses reduce enterovirus 71 lethality in mice by decreasing tissue viral loads.

Journal of virology

Lin YW,Chang KC,Kao CM,Chang SP,Tung YY,Chen SH

11-0041 was used in Flow cytometry/Cell sorting to investigate the functions of lymphocyte and antibody responses in EV71 infection.

Wed Jul 01 00:00:00 EDT 2009

Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy.

Cancer gene therapy

Boczkowski D,Lee J,Pruitt S,Nair S

11-0041 was used in Flow cytometry/Cell sorting to show significantly enhanced tumor immunity through vaccination with a combination of anti-GITR-secreting dendritic cells and tumor antigen-presenting dendritic cells, providing an effective tumor vaccine adjuvant.

Tue Dec 01 00:00:00 EST 2009

The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression.

Journal of immunology (Baltimore, Md. : 1950)

Cen O,Ueda A,Guzman L,Jain J,Bassiri H,Nichols KE,Stein PL

11-0041 was used in Flow cytometry/Cell sorting to study the mechanism by which signalling lymphocytic activation molecule-associated protein exerts control over natural killer T cell development and cytokine production.

Sun Feb 01 00:00:00 EST 2009

4-1BB functions as a survival factor in dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Choi BK,Kim YH,Kwon PM,Lee SC,Kang SW,Kim MS,Lee MJ,Kwon BS

11-0041 was used in Flow cytometry/Cell sorting to investigate the function of CD137 on dendritic cells, showing that it functions as a survival factor.

Wed Apr 01 00:00:00 EDT 2009

Scalable analysis of flow cytometry data using R/Bioconductor.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Klinke DJ,Brundage KM

11-0041 was used in Flow cytometry/Cell sorting to demonstrate usage of a platform for the graphical and data analysis of flow cytometry data.

Sat Aug 01 00:00:00 EDT 2009

Nylon wool purification alters the activation of T cells.

Molecular immunology

Wohler JE,Barnum SR

11-0041 was used in Flow cytometry/Cell sorting to examine the effects of nylon wool purification on T cell proliferation, activation marker expression and cytokine production.

Sun Feb 01 00:00:00 EST 2009

Impact of preexisting vector-specific immunity on vaccine potency: characterization of listeria monocytogenes-specific humoral and cellular immunity in humans and modeling studies using recombinant vaccines in mice.

Infection and immunity

Leong ML,Hampl J,Liu W,Mathur S,Bahjat KS,Luckett W,Dubensky TW,Brockstedt DG

11-0041 was used in Flow cytometry/Cell sorting to establish the level of L. monocytogenes-specific cellular immunity in healthy adults and support the protocol of repeated L. monocytogenes vaccination regimens to elicit a desired therapeutic effect.

Tue Sep 01 00:00:00 EDT 2009

Glutamic acid decarboxylase-derived epitopes with specific domains expand CD4(+)CD25(+) regulatory T cells.

PloS one

Chen G,Han G,Feng J,Wang J,Wang R,Xu R,Shen B,Qian J,Li Y

11-0041 was used in Flow cytometry/Cell sorting to investigate how structural analysis of epitopes may aid predictions of protective epitopes to expand functional Tregs.

Sun Sep 13 00:00:00 EDT 2009

Nitric oxide is a key component in inflammation-accelerated tumorigenesis.

Cancer research

Hussain SP,He P,Subleski J,Hofseth LJ,Trivers GE,Mechanic L,Hofseth AB,Bernard M,Schwank J,Nguyen G,Mathe E,Djurickovic D,Haines D,Weiss J,Back T,Gruys E,Laubach VE,Wiltrout RH,Harris CC

11-0041 was used in Flow cytometry/Cell sorting to test the hypothesis that an inflammatory microenvironment with an enhanced level of nitric oxide accelerates spontaneous tumour development (tumorigenesis).

Mon Sep 01 00:00:00 EDT 2008

H2E-derived Ealpha52-68 peptide presented by H2Ab interferes with clonal deletion of autoreactive T cells in autoimmune thyroiditis.

Journal of immunology (Baltimore, Md. : 1950)

Brown NK,McCormick DJ,David CS,Kong YC

11-0041 was used in Flow cytometry/Cell sorting to investigate the role of H2E-derived Ealpha52-68 peptide in autoimmune thyroiditis.

Thu May 15 00:00:00 EDT 2008

Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses.

Journal of immunology (Baltimore, Md. : 1950)

Drake PM,Nathan JK,Stock CM,Chang PV,Muench MO,Nakata D,Reader JR,Gip P,Golden KP,Weinhold B,Gerardy-Schahn R,Troy FA,Bertozzi CR

11-0041 was used in Flow cytometry/Cell sorting to investigate the expression and possible function of polysialic acid in the immune system.

Sat Nov 15 00:00:00 EST 2008

Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses.

Journal of immunology (Baltimore, Md. : 1950)

Drake PM,Nathan JK,Stock CM,Chang PV,Muench MO,Nakata D,Reader JR,Gip P,Golden KP,Weinhold B,Gerardy-Schahn R,Troy FA,Bertozzi CR

11-0041 was used in Flow cytometry/Cell sorting to investigate the expression and possible function of polysialic acid in the immune system.

Sat Nov 15 00:00:00 EST 2008

Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.

Investigative ophthalmology & visual science

Mochimaru H,Usui T,Yaguchi T,Nagahama Y,Hasegawa G,Usui Y,Shimmura S,Tsubota K,Amano S,Kawakami Y,Ishida S

Thu May 01 00:00:00 EDT 2008

Psychological stress impairs the local CD8+ T cell response to mucosal HSV-1 infection and allows for increased pathogenicity via a glucocorticoid receptor-mediated mechanism.

Psychoneuroendocrinology

Ashcraft KA,Hunzeker J,Bonneau RH

11-0041 was used in Flow cytometry/Cell sorting to determine how psychological stress and associated increases in corticosterone may increase susceptibility to herpes simplex virus encephalitis.

Fri Aug 01 00:00:00 EDT 2008

Pathogenic role of B cells and antibodies in murine Leishmania amazonensis infection.

International journal for parasitology

Wanasen N,Xin L,Soong L

11-0041 was used in Flow cytometry/Cell sorting to suggest that B cell activity enhances L. amazonensis infection by promoting T cell priming and cellular migration to the infection site.

Sat Mar 01 00:00:00 EST 2008

Role of natural killer cells in modulating dendritic cell responses to Leishmania amazonensis infection.

Infection and immunity

Sanabria MX,Vargas-Inchaustegui DA,Xin L,Soong L

11-0041 was used in Flow cytometry/Cell sorting to suggest differential roles of DC-NK cell cross talk at different stages of Leishmania infection.

Sat Nov 01 00:00:00 EDT 2008

Regulatory roles of CD1d-restricted NKT cells in the induction of toxic shock-like syndrome in an animal model of fatal ehrlichiosis.

Infection and immunity

Stevenson HL,Crossley EC,Thirumalapura N,Walker DH,Ismail N

11-0041 was used in Flow cytometry/Cell sorting to investigate the physiopathological roles of natural killer T cells in lethal ehrlichial infection using CD1d-deficient mice.

Tue Apr 01 00:00:00 EDT 2008

RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla.

The Journal of experimental medicine

Rossi SW,Kim MY,Leibbrandt A,Parnell SM,Jenkinson WE,Glanville SH,McConnell FM,Scott HS,Penninger JM,Jenkinson EJ,Lane PJ,Anderson G

11-0041 was used in Flow cytometry/Cell sorting to demonstrate a novel role for a CD4(+)3(-) inducer cell population, showing that RANK signals regulate development of Aire-expressing epithelial cells in the thymic medulla.

Mon Jun 11 00:00:00 EDT 2007

Novel exosome-targeted CD4+ T cell vaccine counteracting CD4+25+ regulatory T cell-mediated immune suppression and stimulating efficient central memory CD8+ CTL responses.

Journal of immunology (Baltimore, Md. : 1950)

Hao S,Liu Y,Yuan J,Zhang X,He T,Wu X,Wei Y,Sun D,Xiang J

11-0041 was used in Flow cytometry/Cell sorting to study the effects of a novel exosome-targeted CD4+ T cell vaccine.

Sat Sep 01 00:00:00 EDT 2007

Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load.

Journal of immunology (Baltimore, Md. : 1950)

Millington KA,Innes JA,Hackforth S,Hinks TS,Deeks JJ,Dosanjh DP,Guyot-Revol V,Gunatheesan R,Klenerman P,Lalvani A

11-0041 was used in Magnetic cell separation to assess the relationship between the profile of IFN-γ- and IL-2-secreting tuberculosis-specific T-cells and antigen load.

Sun Apr 15 00:00:00 EDT 2007

Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.

Circulation

Yang Z,Day YJ,Toufektsian MC,Xu Y,Ramos SI,Marshall MA,French BA,Linden J

Tue Nov 07 00:00:00 EST 2006

An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes.

International immunology

Tellier J,van Meerwijk JP,Romagnoli P

11-0041 was used in Flow cytometry/Cell sorting to investigate factors that affect the levels of Tregs in the thymus.

Wed Nov 01 00:00:00 EST 2006

An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes.

International immunology

Tellier J,van Meerwijk JP,Romagnoli P

11-0041 was used in Flow cytometry/Cell sorting to investigate factors that affect the levels of Tregs in the thymus.

Wed Nov 01 00:00:00 EST 2006

Cytosolic entry controls CD8+-T-cell potency during bacterial infection.

Infection and immunity

Bahjat KS,Liu W,Lemmens EE,Schoenberger SP,Portnoy DA,Dubensky TW,Brockstedt DG

11-0041 was used in Flow cytometry/Cell sorting to investigate microbial invasion of the cytosol as a key factor in inducing CD8+- T cell-mediated protection against L.monocytogenes.

Wed Nov 01 00:00:00 EST 2006

Plasmacytoid dendritic cells of different origins have distinct characteristics and function: studies of lymphoid progenitors versus myeloid progenitors.

Journal of immunology (Baltimore, Md. : 1950)

Yang GX,Lian ZX,Kikuchi K,Moritoki Y,Ansari AA,Liu YJ,Ikehara S,Gershwin ME

11-0041-82 was used in Flow Cytometry to indicate that MPs are multipotential and have the capacity to develop into not only myeloid cells, but also pDCs, which have distinct characteristics and function compared to that of lymphoid origin and, therefore, imply a more important role for MP-derived pDCs in conditions where the function of lymphoid progenitors is impaired or compromised.

Thu Dec 01 00:00:00 EST 2005

Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes.

The Journal of experimental medicine

Auerbuch V,Brockstedt DG,Meyer-Morse N,O'Riordan M,Portnoy DA

11-0041 was used in Flow cytometry/Cell sorting to investigate the role of type I interferon receptors in viral defense using Listeria monocytogenes infection of mice as a model.

Mon Aug 16 00:00:00 EDT 2004

Lack of the growth factor midkine enhances survival against cisplatin-induced renal damage.

The American journal of pathology

Kawai H,Sato W,Yuzawa Y,Kosugi T,Matsuo S,Takei Y,Kadomatsu K,Muramatsu T

11-0041 was used in Immunohistochemistry on frozen tissues to investigate the significance of the secondary effects of cisplatin on proximal tubule survival.

Mon Nov 01 00:00:00 EST 2004

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis.

Proceedings of the National Academy of Sciences of the United States of America

Woolf E,Xiao C,Fainaru O,Lotem J,Rosen D,Negreanu V,Bernstein Y,Goldenberg D,Brenner O,Berke G,Levanon D,Groner Y

Published figure using CD4 monoclonal antibody (Product # 11-0041-82) in Flow Cytometry

Tue Jun 24 00:00:00 EDT 2003

Bioinformatics

Protein Aliases: CD4; CD4 antigen p55; cd4a; fCD4; Leu-3; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4)

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Gene Aliases: Cd4; L3T4; Ly-4

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UniProt ID: (Mouse) P06332

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Entrez Gene ID: (Mouse) 12504

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Function(s)

glycoprotein binding protein binding zinc ion binding coreceptor activity enzyme binding protein kinase binding protein homodimerization activity

Process(es)

cytokine production immune system process induction by virus of host cell-cell fusion immune response cell adhesion cell surface receptor signaling pathway T cell differentiation maintenance of protein location in cell T cell activation T cell selection protein palmitoleylation positive regulation of protein kinase activity positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-negative bacterium positive regulation of calcium-mediated signaling regulation of T cell activation positive regulation of T cell activation

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CD4 Monoclonal Antibody (GK1.5), FITC, eBioscience™

CD4 Antibody (11-0041-82) in Flow

Product Details

11-0041-82

Immunohistochemistry (IHC)

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Immunohistochemistry (Frozen) (IHC (F))

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