Product References
Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge.
Biomaterials
Sun S,Li E,Zhao G,Tang J,Zuo Q,Cai L,Xu C,Sui C,Ou Y,Liu C,Li H,Ding Y,Li C,Lu D,Zhang W,Luo P,Cheng P,Gao Y,Tu C,Pitard B,Rosenecker J,Wang B,Liu Y,Zou Q,Guan S
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2023
HSF1 promotes CD69+ Treg differentiation to inhibit colitis progression.
Theranostics
Yu L,Zhou B,Zhu Y,Li L,Zhong Y,Zhu L,Wang H,Chen H,Xu J,Guo T,Feng L,Wang X,Cai Z,Wang J,Jin H
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Apr 18 00:00:00 EDT 2023
Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-like Autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Hodgson R,Crockford TL,Bhandari A,Kepple JD,Back J,Cawthorne E,Abeler-Dörner L,Laing AG,Clare S,Speak A,Adams DJ,Dougan G,Hayday AC,Deobagkar-Lele M,Cornall RJ,Bull KR
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2023
Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting.
Frontiers in immunology
Clubb JHA,Kudling TV,Girych M,Haybout L,Pakola S,Hamdan F,Cervera-Carrascon V,Hemmes A,Grönberg-Vähä-Koskela S,Santos JM,Quixabeira DCA,Basnet S,Heiniö C,Arias V,Jirovec E,Kaptan S,Havunen R,Sorsa S,Erikat A,Schwartz J,Anttila M,Aro K,Viitala T,Vattulainen I,Cerullo V,Kanerva A,Hemminki A
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Feb 27 00:00:00 EST 2023
GH18 family glycoside hydrolase Chitinase A of Salmonella enhances virulence by facilitating invasion and modulating host immune responses.
PLoS pathogens
Chandra K,Roy Chowdhury A,Chatterjee R,Chakravortty D
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Apr 01 00:00:00 EDT 2022
Rotenone aggravates PD-like pathology in A53T mutant human α-synuclein transgenic mice in an age-dependent manner.
Frontiers in aging neuroscience
Chen AD,Cao JX,Chen HC,Du HL,Xi XX,Sun J,Yin J,Jing YH,Gao LP
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Aug 26 00:00:00 EDT 2022
IL-33 Deficiency Attenuates Lung Inflammation by Inducing Th17 Response and Impacting the Th17/Treg Balance in LPS-Induced ARDS Mice via Dendritic Cells.
Journal of immunology research
Cheng L,Jiao Y,Jiang W,Zhang X,Zhang L,Jia G
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Dec 27 00:00:00 EST 2022
Interferon-γ Stimulates Interleukin-27 Derived from Dendritic Cells to Regulate Th9 Differentiation through STAT1/3 Pathway.
Disease markers
Xiong P,Liu T,Chen Y,Xu Q,Hu X,Han F,Shi L
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Oct 31 00:00:00 EDT 2022
CD4+ CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.
Aging and disease
Shen S,Li Y,Jin M,Fan D,Pan R,Lin A,Chen Y,Xiang L,Zhao RC,Shao J
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2022
Free Fatty Acid Receptor 4 (FFA4) Activation Ameliorates Imiquimod-Induced Psoriasis in Mice.
International journal of molecular sciences
Son SE,Koh JM,Im DS
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Apr 19 00:00:00 EDT 2022
Btla signaling in conventional and regulatory lymphocytes coordinately tempers humoral immunity in the intestinal mucosa.
Cell reports
Stienne C,Virgen-Slane R,Elmén L,Veny M,Huang S,Nguyen J,Chappell E,Balmert MO,Shui JW,Hurchla MA,Kronenberg M,Peterson SN,Murphy KM,Ware CF,Šedý JR
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry
Tue Mar 22 00:00:00 EDT 2022
Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage.
Cell death & disease
Del Rio Oliva M,Basler M
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2022
Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.
Immunity
Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury in a non-human primate model of COVID-19.
Nature nanotechnology
Li Z,Wang Z,Dinh PC,Zhu D,Popowski KD,Lutz H,Hu S,Lewis MG,Cook A,Andersen H,Greenhouse J,Pessaint L,Lobo LJ,Cheng K
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunocytochemistry
Sun Aug 01 00:00:00 EDT 2021
NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.
Nature immunology
Gu M,Zhou X,Sohn JH,Zhu L,Jie Z,Yang JY,Zheng X,Xie X,Yang J,Shi Y,Brightbill HD,Kim JB,Wang J,Cheng X,Sun SC
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase.
International journal of oral science
Zhao X,Liu J,Zhang C,Yu N,Lu Z,Zhang S,Li Y,Li Q,Liu J,Liu D,Pan Y
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Sep 30 00:00:00 EDT 2021
Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.
The Journal of experimental medicine
Sasai M,Ma JS,Okamoto M,Nishino K,Nagaoka H,Takashima E,Pradipta A,Lee Y,Kosako H,Suh PG,Yamamoto M
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
Splicing factor SRSF1 limits IFN-γ production via RhoH and ameliorates experimental nephritis.
Rheumatology (Oxford, England)
Katsuyama T,Li H,Krishfield SM,Kyttaris VC,Moulton VR
14-0041-82 was used in Flow Cytometry to uncover a previously unrecognized role of SRSF1 in restraining IFN-γ production and Th1 differentiation through the control of RhoH.
Tue Jan 05 00:00:00 EST 2021
High Ambient Temperature Aggravates Experimental Autoimmune Uveitis Symptoms.
Frontiers in cell and developmental biology
Pan S,Tan H,Chang R,Wang Q,Zhu Y,Chen L,Li H,Su G,Zhou C,Cao Q,Kijlstra A,Yang P
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Apr 13 00:00:00 EDT 2021
Dynamic changes in the systemic immune responses of spinal cord injury model mice.
Neural regeneration research
Gao TY,Huang FF,Xie YY,Wang WQ,Wang LD,Mu D,Cui Y,Wang B
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
SZB120 Exhibits Immunomodulatory Effects by Targeting eIF2α to Suppress Th17 Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Chen L,Bai J,Peng D,Gao Y,Cai X,Zhang J,Tang S,Niu L,Sun Y,Lou F,Zhou H,Yin Q,Wang Z,Sun L,Du X,Xu Z,Wang H,Li Q,Wang H
14-0041-82 was used in Flow Cytometry to characterise the target and mechanism of an acetylated beta-boswellic acid derivative termed SZB120, and evaluate the anti-inflammatory activities in vitro and in vivo.
Mon Mar 01 00:00:00 EST 2021
Generation of a Novel Oncolytic Vaccinia Virus Using the IHD-W Strain.
Human gene therapy
Shin J,Hong SO,Kim M,Lee H,Choi H,Kim J,Hong J,Kang H,Lee E,Lee S,Kong B,Kim M,Choi H,Kim S
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Oncolytic Herpes Simplex Virus Type 2 Can Effectively Inhibit Colorectal Cancer Liver Metastasis by Modulating the Immune Status in the Tumor Microenvironment and Inducing Specific Antitumor Immunity.
Human gene therapy
Zhang W,Zeng B,Hu X,Zou L,Liang J,Song Y,Liu B,Liu S
14-0041 was used in Immunohistochemistry to show that oHSV2 can effectively kill the primary tumour and attack distal and metastatic tumours by inducing immune responses, resulting in lasting antitumour efficacy and preventing tumour recurrence.
Mon Feb 01 00:00:00 EST 2021
CXCR3 alleviates renal ischemia‑reperfusion injury via increase of Tregs.
Molecular medicine reports
Xian W,Wu J,Li Q,Du X,Wang N,Chen D,Gao W,Cao J
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Jul 01 00:00:00 EDT 2021
Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.
Oncology letters
Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Preliminary analysis of immunoregulatory mechanism of hyperhomocysteinemia-induced brain injury in Wistar-Kyoto rats.
Experimental and therapeutic medicine
Zhang Y,Wang L,Li X,Geng J
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Estrogen receptor beta signaling in CD8+ T cells boosts T cell receptor activation and antitumor immunity through a phosphotyrosine switch.
Journal for immunotherapy of cancer
Yuan B,Clark CA,Wu B,Yang J,Drerup JM,Li T,Jin VX,Hu Y,Curiel TJ,Li R
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells.
JCI insight
de Mattos Barbosa MG,Lefferts AR,Huynh D,Liu H,Zhang Y,Fu B,Barnes J,Samaniego M,Bram RJ,Geha RS,Shikanov A,Prak ETL,Farkash EA,Platt JL,Cascalho M
14-0041-82 was used in Immunohistochemistry (Frozen) to conclude that the wide variation in inflammatory reactions associated with TNFRSF13B diversity suggests polymorphisms could underlie variation in host defense and explosive inflammatory responses that sometimes enhance morbidity associated with immune responses.
Wed Sep 08 00:00:00 EDT 2021
TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells.
JCI insight
de Mattos Barbosa MG,Lefferts AR,Huynh D,Liu H,Zhang Y,Fu B,Barnes J,Samaniego M,Bram RJ,Geha RS,Shikanov A,Prak ETL,Farkash EA,Platt JL,Cascalho M
14-0041-82 was used in Immunohistochemistry (Frozen) to conclude that the wide variation in inflammatory reactions associated with TNFRSF13B diversity suggests polymorphisms could underlie variation in host defense and explosive inflammatory responses that sometimes enhance morbidity associated with immune responses.
Wed Sep 08 00:00:00 EDT 2021
Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy.
Frontiers in immunology
Agalave NM,Mody PH,Szabo-Pardi TA,Jeong HS,Burton MD
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Sep 20 00:00:00 EDT 2021
Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model.
Vaccines
Trofimova O,Korotkaja K,Skrastina D,Jansons J,Spunde K,Isaguliants M,Zajakina A
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Oct 27 00:00:00 EDT 2021
A lymph node-targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2.
Science advances
Steinbuck MP,Seenappa LM,Jakubowski A,McNeil LK,Haqq CM,DeMuth PC
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.
International journal of molecular sciences
Sato S,Shimizu E,He J,Ogawa M,Asai K,Yazu H,Rusch R,Yamane M,Yang F,Fukuda S,Kawakami Y,Tsubota K,Ogawa Y
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry
Sat Apr 03 00:00:00 EDT 2021
Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.
International journal of molecular sciences
Sato S,Shimizu E,He J,Ogawa M,Asai K,Yazu H,Rusch R,Yamane M,Yang F,Fukuda S,Kawakami Y,Tsubota K,Ogawa Y
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry
Sat Apr 03 00:00:00 EDT 2021
Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression.
Clinical and translational medicine
Cheng CS,Tan HY,Wang N,Chen L,Meng Z,Chen Z,Feng Y
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry
Tue Jun 01 00:00:00 EDT 2021
IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation.
Frontiers in immunology
Amobi-McCloud A,Muthuswamy R,Battaglia S,Yu H,Liu T,Wang J,Putluri V,Singh PK,Qian F,Huang RY,Putluri N,Tsuji T,Lugade AA,Liu S,Odunsi K
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Oct 29 00:00:00 EDT 2021
Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells.
Stem cell research & therapy
Liu W,Zhou N,Liu Y,Zhang W,Li X,Wang Y,Zheng R,Zhang Y
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Feb 26 00:00:00 EST 2021
G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence.
Cell death & disease
Sun SN,Ni SH,Li Y,Liu X,Deng JP,Chen ZX,Li H,Feng WJ,Huang YS,Li DN,Xian SX,Yang ZQ,Wang LJ,Lu L
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Jun 08 00:00:00 EDT 2021
Butyrate Improves Skin/Lung Fibrosis and Intestinal Dysbiosis in Bleomycin-Induced Mouse Models.
International journal of molecular sciences
Park HJ,Jeong OY,Chun SH,Cheon YH,Kim M,Kim S,Lee SI
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Mar 09 00:00:00 EST 2021
Mapping Rora expression in resting and activated CD4+ T cells.
PloS one
Haim-Vilmovsky L,Henriksson J,Walker JA,Miao Z,Natan E,Kar G,Clare S,Barlow JL,Charidemou E,Mamanova L,Chen X,Proserpio V,Pramanik J,Woodhouse S,Protasio AV,Efremova M,Griffin JL,Berriman M,Dougan G,Fisher J,Marioni JC,McKenzie ANJ,Teichmann SA
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Nov 12 00:00:00 EST 2021
Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid.
The Journal of biological chemistry
Zhao Y,Cheng R,Zhao Y,Ge W,Yang Y,Ding Z,Xu X,Wang Z,Wu Z,Zhang J
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Oct 01 00:00:00 EDT 2021
Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.
Cancers
Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Oct 07 00:00:00 EDT 2021
Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.
Cancers
Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Oct 07 00:00:00 EDT 2021
A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.
Nature communications
Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Sep 30 00:00:00 EDT 2021
Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Sang W,Xie L,Wang G,Li J,Zhang Z,Li B,Guo S,Deng CX,Dai Y
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Systemic Delivery of Oncolytic Adenovirus to Tumors Using Tumor-Infiltrating Lymphocytes as Carriers.
Cells
Santos J,Heiniö C,Quixabeira D,Zafar S,Clubb J,Pakola S,Cervera-Carrascon V,Havunen R,Kanerva A,Hemminki A
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Apr 22 00:00:00 EDT 2021
Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response.
Cell reports
Vaena S,Chakraborty P,Lee HG,Janneh AH,Kassir MF,Beeson G,Hedley Z,Yalcinkaya A,Sofi MH,Li H,Husby ML,Stahelin RV,Yu XZ,Mehrotra S,Ogretmen B
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunocytochemistry
Tue May 04 00:00:00 EDT 2021
Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.
Theranostics
Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Jan 28 00:00:00 EST 2022
Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair.
Frontiers in immunology
Ramavath NN,Gadipudi LL,Provera A,Gigliotti LC,Boggio E,Bozzola C,Albano E,Dianzani U,Sutti S
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Feb 14 00:00:00 EST 2022
Remote Limb Ischemic Postconditioning Protects Against Ischemic Stroke by Promoting Regulatory T Cells Thriving.
Journal of the American Heart Association
Yu HH,Ma XT,Ma X,Chen M,Chu YH,Wu LJ,Wang W,Qin C,Tian DS
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Nov 16 00:00:00 EST 2021
Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.
Frontiers in immunology
Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.
Frontiers in immunology
Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.
Immunity
Bonavita E,Bromley CP,Jonsson G,Pelly VS,Sahoo S,Walwyn-Brown K,Mensurado S,Moeini A,Flanagan E,Bell CR,Chiang SC,Chikkanna-Gowda CP,Rogers N,Silva-Santos B,Jaillon S,Mantovani A,Reis e Sousa C,Guerra N,Davis DM,Zelenay S
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Dec 15 00:00:00 EST 2020
Splenic Capture and In Vivo Intracellular Biodegradation of Biological-Grade Graphene Oxide Sheets.
ACS nano
Newman L,Jasim DA,Prestat E,Lozano N,de Lazaro I,Nam Y,Assas BM,Pennock J,Haigh SJ,Bussy C,Kostarelos K
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Aug 25 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells.
PLoS pathogens
Akhtar MN,Mishra M,Yadav V,Yadav M,Gujar R,Lal S,Kumar R,Khatri N,Sen P
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2020
DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma.
Journal of cellular and molecular medicine
Song Y,Wang Z,Jiang J,Piao Y,Li L,Xu C,Piao H,Li L,Yan G
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2020
Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.
Journal of cellular and molecular medicine
Wu R,Liu C,Deng X,Chen L,Hao S,Ma L
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2020
HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.
Journal of Cancer
Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Sep 28 00:00:00 EDT 2020
Loss of Setd4 delays radiation-induced thymic lymphoma in mice.
DNA repair
Feng X,Lu H,Yue J,Schneider N,Liu J,Denzin LK,Chan CS,De S,Shen Z
14-0041 was used in Immunohistochemistry to report that conditional Setd4 deletion in adult mice significantly extended the survival of radiation-induced T-lymphoma.
Sat Feb 01 00:00:00 EST 2020
Effects of combined treatment with PD‑L1 Ig and CD40L mAb on immune tolerance in the CBA/J x DBA/2 mouse model.
Molecular medicine reports
Li G,Yang L,Li D,Zhang J,Du L,Xia L,Liu Y,Hu W
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
FUT1 deficiency elicits immune dysregulation and corneal opacity in steady state and under stress.
Cell death & disease
Kim KW,Ryu JS,Ko JH,Kim JY,Kim HJ,Lee HJ,Oh JH,Chung JH,Oh JY
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Apr 24 00:00:00 EDT 2020
Elevated granulocytic myeloid-derived suppressor cells are closely related with elevation of Th17 cells in mice with experimental asthma.
International journal of biological sciences
Xue F,Yu M,Li L,Zhang W,Ma Y,Dong L,Shan W,Zheng Y,Wang T,Feng D,Lv J,Wang X
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Nov 12 00:00:00 EST 2021
Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.
International journal of molecular sciences
Yoon CH,Ryu JS,Hwang HS,Kim MK
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Jun 11 00:00:00 EDT 2020
Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma.
Cells
Martinikova AS,Burocziova M,Stoyanov M,Macurek L
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Sep 10 00:00:00 EDT 2020
Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.
JCI insight
Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Aug 20 00:00:00 EDT 2020
Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.
Communications biology
Waaler J,Mygland L,Tveita A,Strand MF,Solberg NT,Olsen PA,Aizenshtadt A,Fauskanger M,Lund K,Brinch SA,Lycke M,Dybing E,Nygaard V,Bøe SL,Heintz KM,Hovig E,Hammarström C,Corthay A,Krauss S
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Apr 24 00:00:00 EDT 2020
A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation.
Science advances
Niu L,Lou F,Sun Y,Sun L,Cai X,Liu Z,Zhou H,Wang H,Wang Z,Bai J,Yin Q,Zhang J,Chen L,Peng D,Xu Z,Gao Y,Tang S,Fan L,Wang H
14-0041-82 was used in Flow Cytometry to demonstrate the endogenous existence of a micropeptide encoded by a transcript annotated as "non-protein coding" and characterize a micropeptide as a regulator of antigen presentation and a suppressor of inflammatory diseases.
Fri May 01 00:00:00 EDT 2020
The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function.
International journal of molecular sciences
Subbannayya Y,Haug M,Pinto SM,Mohanty V,Meås HZ,Flo TH,Prasad TSK,Kandasamy RK
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Dec 29 00:00:00 EST 2020
Antimesothelioma Immunotherapy by CTLA-4 Blockade Depends on Active PD1-Based TWIST1 Vaccination.
Molecular therapy oncolytics
Tan Z,Chiu MS,Yan CW,Wong YC,Huang H,Man K,Chen Z
14-0041-82 was used in Flow Cytometry to demonstrate that TWIST1, the basic helix-loop-helix transcription factor, was associated with human mesothelioma tumorigenesis and is required for the invasion and metastasis of mesothelioma in the immune-competent murine AB1 model.
Fri Mar 27 00:00:00 EDT 2020
ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.
PloS one
Hanson A,Elpek K,Duong E,Shallberg L,Fan M,Johnson C,Wallace M,Mabry GR,Sazinsky S,Pepper L,Shu CJ,Sathyanarayanan S,Zuerndorfer S,Simpson T,Gostissa M,Briskin M,Law D,Michaelson J,Harvey CJ
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Nov 16 00:00:00 EST 2020
Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.
Scientific reports
Kedzierska AE,Lorek D,Slawek A,Chelmonska-Soyta A
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Jun 29 00:00:00 EDT 2020
Distinct Waves from the Hemogenic Endothelium Give Rise to Layered Lymphoid Tissue Inducer Cell Ontogeny.
Cell reports
Simic M,Manosalva I,Spinelli L,Gentek R,Shayan RR,Siret C,Girard-Madoux M,Wang S,de Fabritus L,Verschoor J,Kerdiles YM,Bajenoff M,Stumm R,Golub R,van de Pavert SA
14-0041-81 was used in Immunocytochemistry to identify a major contribution from embryonic hemogenic endothelium, but not the yolk sac, toward LTi progenitors.
Tue Aug 11 00:00:00 EDT 2020
Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.
Frontiers in immunology
Yu Y,Wu DM,Li J,Deng SH,Liu T,Zhang T,He M,Zhao YY,Xu Y
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Jun 21 00:00:00 EDT 2021
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.
Nature
Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Jul 01 00:00:00 EDT 2019
TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis.
Nature cell biology
Zhu L,Li Y,Xie X,Zhou X,Gu M,Jie Z,Ko CJ,Gao T,Hernandez BE,Cheng X,Sun SC
14-0041 was used in Flow cytometry/Cell sorting to suggest a PKCθ-TBKBP1-TBK1 growth factor signalling axis that mediates both tumour growth and immunosuppression.
Sun Dec 01 00:00:00 EST 2019
Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis.
Blood
Albeituni S,Verbist KC,Tedrick PE,Tillman H,Picarsic J,Bassett R,Nichols KE
14-0041-82 was used in Flow Cytometry to show that ruxolitinib operates through IFN-γ-dependent and -independent mechanisms to dampen HLH by targeting the deleterious effects of T cells and neutrophils, with the latter representing an unappreciated and understudied cell type that contributes to HLH pathogenesis.
Thu Jul 11 00:00:00 EDT 2019
Repurposing the selective estrogen receptor modulator bazedoxifene to suppress gastrointestinal cancer growth.
EMBO molecular medicine
Thilakasiri P,Huynh J,Poh AR,Tan CW,Nero TL,Tran K,Parslow AC,Afshar-Sterle S,Baloyan D,Hannan NJ,Buchert M,Scott AM,Griffin MD,Hollande F,Parker MW,Putoczki TL,Ernst M,Chand AL
14-0041-82 was used in Flow Cytometry to establish the in vivo utility of bazedoxifene, a steroid analog clinically approved for the treatment of osteoporosis, to suppress gp130-dependent tumor growth of the gastrointestinal epithelium.
Mon Apr 01 00:00:00 EDT 2019
GARP Dampens Cancer Immunity by Sustaining Function and Accumulation of Regulatory T Cells in the Colon.
Cancer research
Salem M,Wallace C,Velegraki M,Li A,Ansa-Addo E,Metelli A,Kwon H,Riesenberg B,Wu B,Zhang Y,Guglietta S,Sun S,Liu B,Li Z
14-0041-82 was used in Flow Cytometry to demonstrate that loss of GARP in Treg cells leads to spontaneous inflammation with highly activated CD4+ and CD8+ T cells and development of enteritis.
Fri Mar 15 00:00:00 EDT 2019
Fimasartan reduces neointimal formation and inflammation after carotid arterial injury in apolipoprotein E knockout mice.
Molecular medicine (Cambridge, Mass.)
Kim JH,Lim IR,Joo HJ,Park CY,Choi SC,Jeong HS,Hong SJ
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry
Mon Jul 15 00:00:00 EDT 2019
Fimasartan reduces neointimal formation and inflammation after carotid arterial injury in apolipoprotein E knockout mice.
Molecular medicine (Cambridge, Mass.)
Kim JH,Lim IR,Joo HJ,Park CY,Choi SC,Jeong HS,Hong SJ
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry
Mon Jul 15 00:00:00 EDT 2019
Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.
Laboratory investigation; a journal of technical methods and pathology
Hensel JA,Khattar V,Ashton R,Ponnazhagan S
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Jan 01 00:00:00 EST 2019
Bryostatin-1 ameliorated experimental colitis in Il-10-/- Mice by protecting the intestinal barrier and limiting immune dysfunction.
Journal of cellular and molecular medicine
Zuo L,Li J,Ge S,Ge Y,Shen M,Wang Y,Zhou C,Wu R,Hu J
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Aug 01 00:00:00 EDT 2019
Lactobacillus rhamnosus GG attenuates tenofovir disoproxil fumarate-induced bone loss in male mice via gut-microbiota-dependent anti-inflammation.
Therapeutic advances in chronic disease
Liu H,Gu R,Li W,Zhou W,Cong Z,Xue J,Liu Y,Wei Q,Zhou Y
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Sat Apr 09 00:00:00 EDT 2022
Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway.
Mediators of inflammation
Xu Y,Tang X,Yang M,Zhang S,Li S,Chen Y,Liu M,Guo Y,Lu M
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Jun 11 00:00:00 EDT 2019
Diabetes-mediated IL-17A enhances retinal inflammation, oxidative stress, and vascular permeability.
Cellular immunology
Sigurdardottir S,Zapadka TE,Lindstrom SI,Liu H,Taylor BE,Lee CA,Kern TS,Taylor PR
14-0041-82 was used in Flow Cytometry to examine the role of IL-17A in the development of retinal inflammation and long-term vascular pathology in diabetic mice.
Mon Jul 01 00:00:00 EDT 2019
IL-31 plays dual roles in lung inflammation in an OVA-induced murine asthma model.
Biology open
Huang J,Yue H,Jiang T,Gao J,Shi Y,Shi B,Wu X,Gou X
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Jan 15 00:00:00 EST 2019
Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.
Anti-cancer drugs
Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2019
Epithelial EP4 plays an essential role in maintaining homeostasis in colon.
Scientific reports
Matsumoto Y,Nakanishi Y,Yoshioka T,Yamaga Y,Masuda T,Fukunaga Y,Sono M,Yoshikawa T,Nagao M,Araki O,Ogawa S,Goto N,Hiramatsu Y,Breyer RM,Fukuda A,Seno H
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry
Wed Oct 23 00:00:00 EDT 2019
Specific Inhibition of Soluble γc Receptor Attenuates Collagen-Induced Arthritis by Modulating the Inflammatory T Cell Responses.
Frontiers in immunology
Lee B,Jo Y,Kim G,Ali LA,Sohn DH,Lee SG,Kim K,Shin E,Ryu SH,Hong C
14-0041 was used in Flow cytometry/Cell sorting to block the functions of sγc by inhibiting the formation of homodimeric sγc.
Tue Feb 25 00:00:00 EST 2020
An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses.
NPJ vaccines
Li G,Adam A,Luo H,Shan C,Cao Z,Fontes-Garfias CR,Sarathy VV,Teleki C,Winkelmann ER,Liang Y,Sun J,Bourne N,Barrett ADT,Shi PY,Wang T
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
Next Generation Sequencing for Long Non-coding RNAs Profile for CD4+ T Cells in the Mouse Model of Acute Asthma.
Frontiers in genetics
Wang Z,Ji N,Chen Z,Wu C,Sun Z,Yu W,Hu F,Huang M,Zhang M
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Apr 08 00:00:00 EDT 2022
Sex Differences in Mouse Popliteal Lymph Nodes.
Scientific reports
Dill-Garlow R,Chen KE,Walker AM
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Jan 30 00:00:00 EST 2019
TLR1/2 Specific Small-Molecule Agonist Suppresses Leukemia Cancer Cell Growth by Stimulating Cytotoxic T Lymphocytes.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Cen X,Zhu G,Yang J,Yang J,Guo J,Jin J,Nandakumar KS,Yang W,Yin H,Liu S,Cheng K
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri May 17 00:00:00 EDT 2019
Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation.
JCI insight
Kono M,Maeda K,Stocton-Gavanescu I,Pan W,Umeda M,Katsuyama E,Burbano C,Orite SYK,Vukelic M,Tsokos MG,Yoshida N,Tsokos GC
14-0041 was used in Flow cytometry/Cell sorting to demonstrate that CaMK4 binds to PKM2 and promotes its activity, which is requisite for Th1 and Th17 differentiation.
Thu Jun 20 00:00:00 EDT 2019
Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection.
Frontiers in immunology
Schreiber M,Weigelt M,Karasinsky A,Anastassiadis K,Schallenberg S,Petzold C,Bonifacio E,Kretschmer K,Hommel A
14-0041 was used in Flow cytometry/Cell sorting to show that transient hyperexpression of IL-7 can impair immune regulation, through disturbances in lymphocyte development pathways, and decrease graft survival time, even under immunosuppression.
Mon Sep 14 00:00:00 EDT 2020
Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.
Oncoimmunology
Salerno F,Guislain A,Freen-Van Heeren JJ,Nicolet BP,Young HA,Wolkers MC
14-0041 was used in Flow cytometry/Cell sorting to conclude that post-transcriptional mechanisms could be modulated to potentiate effective T cell therapies in cancer.
Tue Jan 12 00:00:00 EST 2021
Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles.
Cell reports
Cianciaruso C,Beltraminelli T,Duval F,Nassiri S,Hamelin R,Mozes A,Gallart-Ayala H,Ceada Torres G,Torchia B,Ries CH,Ivanisevic J,De Palma M
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Jun 04 00:00:00 EDT 2019
CXCR5-negative natural killer cells ameliorate experimental autoimmune myasthenia gravis by suppressing follicular helper T cells.
Journal of neuroinflammation
Yang CL,Zhang P,Liu RT,Zhang N,Zhang M,Li H,Du T,Li XL,Dou YC,Duan RS
14-0041-82 was used in Flow Cytometry to investigate the function of NK cells in experimental autoimmune myasthenia gravis in vivo.
Sun Dec 29 00:00:00 EST 2019
Virus-Induced Interferon-γ Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity.
Immunity
Šestan M,Marinović S,Kavazović I,Cekinović Đ,Wueest S,Turk Wensveen T,Brizić I,Jonjić S,Konrad D,Wensveen FM,Polić B
14-0041 was used in Flow cytometry/Cell sorting to study how viral infection effects insulin resistance.
Tue Jul 17 00:00:00 EDT 2018
Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells.
Immunity
Halim TYF,Rana BMJ,Walker JA,Kerscher B,Knolle MD,Jolin HE,Serrao EM,Haim-Vilmovsky L,Teichmann SA,Rodewald HR,Botto M,Vyse TJ,Fallon PG,Li Z,Withers DR,McKenzie ANJ
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Jun 19 00:00:00 EDT 2018
Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling.
The Journal of clinical investigation
Emmerson A,Trevelin SC,Mongue-Din H,Becker PD,Ortiz C,Smyth LA,Peng Q,Elgueta R,Sawyer G,Ivetic A,Lechler RI,Lombardi G,Shah AM
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Jul 02 00:00:00 EDT 2018
Autophagy orchestrates the regulatory program of tumor-associated myeloid-derived suppressor cells.
The Journal of clinical investigation
Alissafi T,Hatzioannou A,Mintzas K,Barouni RM,Banos A,Sormendi S,Polyzos A,Xilouri M,Wielockx B,Gogas H,Verginis P
14-0041 was used in Immunofluorescence in immunohistochemistry on frozen tissues to identify autophagy as a crucial pathway for myeloid-derived suppressor cell-mediated suppression of antitumour immunity.
Fri Aug 31 00:00:00 EDT 2018
The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.
The Journal of experimental medicine
Zhang W,Li Q,Li D,Li J,Aki D,Liu YC
14-0041 was used in Flow cytometry/Cell sorting to show VHL regulates alveolar macrophages and acts as a crucial egulatory factor in lung inflammation and fibrosis.
Mon Dec 03 00:00:00 EST 2018
Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.
Molecular therapy : the journal of the American Society of Gene Therapy
Ricca JM,Oseledchyk A,Walther T,Liu C,Mangarin L,Merghoub T,Wolchok JD,Zamarin D
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Apr 04 00:00:00 EDT 2018
Long-term health in recipients of transplanted in vitro propagated spermatogonial stem cells.
Human reproduction (Oxford, England)
Mulder CL,Catsburg LAE,Zheng Y,de Winter-Korver CM,van Daalen SKM,van Wely M,Pals S,Repping S,van Pelt AMM
Mon Jan 01 00:00:00 EST 2018
MicroRNA-126 deficiency enhanced the activation and function of CD4+ T cells by elevating IRS-1 pathway.
Clinical and experimental immunology
Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Feb 01 00:00:00 EST 2018
STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Majri SS,Fritz JM,Villarino AV,Zheng L,Kanellopoulou C,Chaigne-Delalande B,Grönholm J,Niemela JE,Afzali B,Biancalana M,Pittaluga S,Sun A,Cohen JL,Holland SM,O'Shea JJ,Uzel G,Lenardo MJ
14-0041 was used in Flow cytometry/Cell sorting to show that STAT5B, a transcription factor downstream of multiple cytokines involved in RICD, is essential for triggering apoptosis of mouse and human TEM cells, and that altered STAT5B transcriptional activity drives immunodeficiency and dysfunction.
Mon Jan 01 00:00:00 EST 2018
Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells.
World journal of gastroenterology
Müller-Graff FT,Fitzner B,Jaster R,Vollmar B,Zechner D
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Sat Jul 28 00:00:00 EDT 2018
Radiation Therapy Combined with Cowpea Mosaic Virus Nanoparticle in Situ Vaccination Initiates Immune-Mediated Tumor Regression.
ACS omega
Patel R,Czapar AE,Fiering S,Oleinick NL,Steinmetz NF
14-0041 was used in Immunohistochemistry to test a novel immunotherapeutic approach utilising combination radiation therapy with immunostimulatory cowpea mosaic virus in a preclinical syngeneic mouse model of ovarian carcinoma.
Mon Apr 30 00:00:00 EDT 2018
Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.
Evidence-based complementary and alternative medicine : eCAM
Pang P,Zheng K,Wu S,Xu H,Deng L,Shi Y,Chen X
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.
Nature communications
Xu Y,Ikeda S,Sumida K,Yamamoto R,Tanaka H,Minato N
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Mar 02 00:00:00 EST 2018
Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.
JCI insight
McCall CE,Zabalawi M,Liu T,Martin A,Long DL,Buechler NL,Arts RJW,Netea M,Yoza BK,Stacpoole PW,Vachharajani V
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Aug 09 00:00:00 EDT 2018
Inhibition of Rspo-Lgr4 Facilitates Checkpoint Blockade Therapy by Switching Macrophage Polarization.
Cancer research
Tan B,Shi X,Zhang J,Qin J,Zhang N,Ren H,Qian M,Siwko S,Carmon K,Liu Q,Han H,Du B,Liu M
14-0041-82 was used in Flow cytometry/Cell sorting to identify Lgr4 as a critical switch in TAMs polarization and a potentially good drug target for cancer immune therapy.
Sat Sep 01 00:00:00 EDT 2018
Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.
eLife
Lian G,Gnanaprakasam JR,Wang T,Wu R,Chen X,Liu L,Shen Y,Yang M,Yang J,Chen Y,Vasiliou V,Cassel TA,Green DR,Liu Y,Fan TW,Wang R
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Sep 10 00:00:00 EDT 2018
A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.
Nature communications
Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Apr 18 00:00:00 EDT 2018
Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Peng J,Xiao Y,Li W,Yang Q,Tan L,Jia Y,Qu Y,Qian Z
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue May 01 00:00:00 EDT 2018
A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.
eLife
Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Nov 20 00:00:00 EST 2018
Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.
Journal of neuroinflammation
Unger MS,Schernthaner P,Marschallinger J,Mrowetz H,Aigner L
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Sep 21 00:00:00 EDT 2018
The Potential Role of a Soluble γ-Chain Cytokine Receptor as a Regulator of IL-7-Induced Lymphoproliferative Disorders.
International journal of molecular sciences
Kim G,Jo Y,Lee B,Ali LA,Lee B,Hong C
14-0041 was used in Flow cytometry/Cell sorting to determine whether IL-7-induced lymphoproliferative disorders could be regulated using a soluble γ-chain cytokine receptor.
Sun Oct 28 00:00:00 EDT 2018
Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung.
Frontiers in physiology
Lim D,Kim W,Lee C,Bae H,Kim J
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Sep 30 00:00:00 EDT 2020
TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival.
Nature communications
Zhu L,Xie X,Zhang L,Wang H,Jie Z,Zhou X,Shi J,Zhao S,Zhang B,Cheng X,Sun SC
14-0041 was used in Flow cytometry/Cell sorting to study the mechanism of IL-15 function in autophagy and natural killer cell survival.
Wed Jul 18 00:00:00 EDT 2018
Plasmodium co-infection protects against chikungunya virus-induced pathologies.
Nature communications
Teo TH,Lum FM,Ghaffar K,Chan YH,Amrun SN,Tan JJL,Lee CYP,Chua TK,Carissimo G,Lee WWL,Claser C,Rajarethinam R,Rénia L,Ng LFP
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Sep 25 00:00:00 EDT 2018
Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects.
Journal of experimental & clinical cancer research : CR
Xu L,Zhang Y,Tian K,Chen X,Zhang R,Mu X,Wu Y,Wang D,Wang S,Liu F,Wang T,Zhang J,Liu S,Zhang Y,Tu C,Liu H
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Oct 29 00:00:00 EDT 2018
Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice.
mSphere
Quach D,Collins F,Parameswaran N,McCabe L,Britton RA
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.
Immunity
Vaeth M,Maus M,Klein-Hessling S,Freinkman E,Yang J,Eckstein M,Cameron S,Turvey SE,Serfling E,Berberich-Siebelt F,Possemato R,Feske S
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Oct 17 00:00:00 EDT 2017
Caveolin-1-dependent nanoscale organization of the BCR regulates B cell tolerance.
Nature immunology
Minguet S,Kläsener K,Schaffer AM,Fiala GJ,Osteso-Ibánez T,Raute K,Navarro-Lérida I,Hartl FA,Seidl M,Reth M,Del Pozo MA
14-0041 was used in Flow cytometry/Cell sorting to study the role of Caveolin-1 in controlling the distribution of nanoclusters of isotype-specific B cell antigen receptors on the surface of B cells.
Sun Oct 01 00:00:00 EDT 2017
A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.
The Journal of clinical investigation
Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling.
The Journal of clinical investigation
Ansa-Addo EA,Zhang Y,Yang Y,Hussey GS,Howley BV,Salem M,Riesenberg B,Sun S,Rockey DC,Karvar S,Howe PH,Liu B,Li Z
14-0041 was used in Flow cytometry/Cell sorting to investigate whether moesin plays a role during the generation of TGF-β-induced Tregs, showing that it controls Treg differentiation and antitumor immunity.
Mon Apr 03 00:00:00 EDT 2017
LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Xu X,Han L,Zhao G,Xue S,Gao Y,Xiao J,Zhang S,Chen P,Wu ZY,Ding J,Hu R,Wei B,Wang H
14-0041 was used in Flow cytometry/Cell sorting to demonstrate LRCH1 as a novel effector to restrain PKCα-DOCK8-Cdc42 module-induced T cell migration and ameliorate EAE.
Sun Jan 01 00:00:00 EST 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Jun 05 00:00:00 EDT 2017
Mast cells acquire MHCII from dendritic cells during skin inflammation.
The Journal of experimental medicine
Dudeck J,Medyukhina A,Fröbel J,Svensson CM,Kotrba J,Gerlach M,Gradtke AC,Schröder B,Speier S,Figge MT,Dudeck A
14-0041 was used in Flow cytometry/Cell sorting to identify an innate intercellular communication arming resident mast cells with key dendritic cell(DC) functions that might contribute to the acute defence potential during critical periods of migration-based DC absence.
Mon Dec 04 00:00:00 EST 2017
MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation.
The Journal of experimental medicine
Singh PB,Pua HH,Happ HC,Schneider C,von Moltke J,Locksley RM,Baumjohann D,Ansel KM
14-0041 was used in Flow cytometry/Cell sorting to establish the physiological requirements for miRNAs in ILC2 homeostasis and immune function ans compare the global miRNA repertoire of resting and activated ILC2s and T helper type 2 cells.
Mon Dec 04 00:00:00 EST 2017
Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity.
The Journal of experimental medicine
Chen S,Cai C,Li Z,Liu G,Wang Y,Blonska M,Li D,Du J,Lin X,Yang M,Dong Z
14-0041-82 was used in Flow Cytometry to examine NKT cell development and humoral immunity in mice completely deficient in SFR.
Wed Feb 01 00:00:00 EST 2017
Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination.
Cancer research
Jiang H,Rivera-Molina Y,Gomez-Manzano C,Clise-Dwyer K,Bover L,Vence LM,Yuan Y,Lang FF,Toniatti C,Hossain MB,Fueyo J
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Sat Jul 15 00:00:00 EDT 2017
Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms.
Proceedings of the National Academy of Sciences of the United States of America
Briseño CG,Gargaro M,Durai V,Davidson JT,Theisen DJ,Anderson DA,Novack DV,Murphy TL,Murphy KM
14-0041 was used in Flow cytometry/Cell sorting to suggest that there is an unrecognized but critical role for RelB within the nonhematopoietic niche that controls normal myelopoiesis.
Tue Apr 11 00:00:00 EDT 2017
Activated T Lymphocytes are Essential Drivers of Pathological Remodeling in Ischemic Heart Failure.
Circulation. Heart failure
Bansal SS,Ismahil MA,Goel M,Patel B,Hamid T,Rokosh G,Prabhu SD
Wed Mar 01 00:00:00 EST 2017
The Spontaneous Autoimmune Neuromyopathy in ICOSL-/- NOD Mice Is CD4+ T-Cell and Interferon-γ Dependent.
Frontiers in immunology
Briet C,Bourdenet G,Rogner UC,Becourt C,Tardivel I,Drouot L,Arnoult C,do Rego JC,Prevot N,Massaad C,Boyer O,Boitard C
14-0041 was used in Immunohistochemistry to characterise the ICOSL-/-NOD model.
Wed Nov 20 00:00:00 EST 2019
An Antigen-Presenting and Apoptosis-Inducing Polymer Microparticle Prolongs Alloskin Graft Survival by Selectively and Markedly Depleting Alloreactive CD8+ T Cells.
Frontiers in immunology
Wang W,Shahzad KA,Li M,Zhang A,Zhang L,Xu T,Wan X,Shen C
14-0041 was used in Immunohistochemistry to document the high potential of PLGA MP-based KaAPCs as a novel antigen-specific immunotherapy for allograft rejection and autoimmune disorder.
Wed Nov 20 00:00:00 EST 2019
Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.
Acta pharmacologica Sinica
Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
Minimally manipulated murine regulatory T cells purified by reversible Fab Multimers are potent suppressors for adoptive T-cell therapy.
European journal of immunology
Mohr F,Fischer JC,Nikolaus M,Stemberger C,Dreher S,Verschoor A,Haas T,Poeck H,Busch DH
14-0041 was used in Flow cytometry/Cell sorting to demonstrate how reversible Fab multimer-based murine regulatory T cell (Treg) isolation can prevent conventional antibody label-induced interferences, and offer higher potency when applied to Treg-based therapies.
Fri Dec 01 00:00:00 EST 2017
NCR1-deficiency diminishes the generation of protective murine cytomegalovirus antibodies by limiting follicular helper T-cell maturation.
European journal of immunology
Miletic A,Lenartic M,Popovic B,Brizic I,Trsan T,Miklic K,Mandelboim O,Krmpotic A,Jonjic S
14-0041 was used in Flow cytometry/Cell sorting to provide evidence for the role of NCR1 in antibody response to mouse cytomegalovirus infection.
Fri Sep 01 00:00:00 EDT 2017
Thymidine Kinase-Negative Herpes Simplex Virus 1 Can Efficiently Establish Persistent Infection in Neural Tissues of Nude Mice.
Journal of virology
Huang CY,Yao HW,Wang LC,Shen FH,Hsu SM,Chen SH
14-0041 was used in Flow cytometry/Cell sorting to investigate the significance of viral thymidine kinase and host T cells for the persistence of Herpes simplex virus-1 in neural tissues.
Wed Feb 15 00:00:00 EST 2017
Cornea lymphatics drive the CD8+ T-cell response to herpes simplex virus-1.
Immunology and cell biology
Gurung HR,Carr MM,Carr DJ
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2017
ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.
RNA biology
Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu May 04 00:00:00 EDT 2017
Protection against Streptococcus pneumoniae Invasive Pathogenesis by a Protein-Based Vaccine Is Achieved by Suppression of Nasopharyngeal Bacterial Density during Influenza A Virus Coinfection.
Infection and immunity
Khan MN,Xu Q,Pichichero ME
14-0041 was used in Flow cytometry/Cell sorting to show an outcome with regard to prevention of invasive S. pneumoniae pathogenesis with a protein vaccine similar to that which occurs with a glycoconjugate vaccine despite a less robust reduction in nasopharynx bacterial density.
Wed Feb 01 00:00:00 EST 2017
Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery.
Scientific reports
Ai J,Li J,Gessler DJ,Su Q,Wei Q,Li H,Gao G
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunofluorescence
Mon Jan 09 00:00:00 EST 2017
Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated with Suppressed Inflammatory Transcriptional Networks in the Mouse Colon.
Frontiers in physiology
Yang T,Ahmari N,Schmidt JT,Redler T,Arocha R,Pacholec K,Magee KL,Malphurs W,Owen JL,Krane GA,Li E,Wang GP,Vickroy TW,Raizada MK,Martyniuk CJ,Zubcevic J
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunofluorescence
Thu Oct 01 00:00:00 EDT 2020
Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease.
Scientific reports
Ogawa Y,He H,Mukai S,Imada T,Nakamura S,Su CW,Mahabole M,Tseng SC,Tsubota K
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry
Mon Feb 06 00:00:00 EST 2017
Location of tumor affects local and distant immune cell type and number.
Immunity, inflammation and disease
Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
Alternative activation generates IL-10 producing type 2 innate lymphoid cells.
Nature communications
Seehus CR,Kadavallore A,Torre B,Yeckes AR,Wang Y,Tang J,Kaye J
14-0041 was used in Functional assays to demonstrate the generation of a previously unappreciated IL-10 producing type 2 innate lymphoid cell effector cell population.
Fri Dec 01 00:00:00 EST 2017
Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury.
Stem cell research & therapy
Zhu D,Tan J,Maleken AS,Muljadi R,Chan ST,Lau SN,Elgass K,Leaw B,Mockler J,Chambers D,Leeman KT,Kim CF,Wallace EM,Lim R
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Nov 10 00:00:00 EST 2017
A robust in vitro model for trans-lymphatic endothelial migration.
Scientific reports
Xiong Y,Brinkman CC,Famulski KS,Mongodin EF,Lord CJ,Hippen KL,Blazar BR,Bromberg JS
14-0041 was used in Flow cytometry/Cell sorting to establish an in vitro system to evaluate lymphatic Trans-endothelial migration for various cell types across primary mouse and human lymphatic endothelial cells.
Tue May 09 00:00:00 EDT 2017
Relevance of CCL3/CCR5 axis in oral carcinogenesis.
Oncotarget
da Silva JM,Moreira Dos Santos TP,Sobral LM,Queiroz-Junior CM,Rachid MA,Proudfoot AEI,Garlet GP,Batista AC,Teixeira MM,Leopoldino AM,Russo RC,Silva TA
14-0041 was used in Immunohistochemistry to show how, in oral carcinogenesis, CCL3/CCR5 axis has pro-tumourigenic effects by inflammatory and angiogenic pathway induction and recruitment of eosinophils.
Tue Aug 01 00:00:00 EDT 2017
MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis.
Stem cell reports
Shigemoto-Kuroda T,Oh JY,Kim DK,Jeong HJ,Park SY,Lee HJ,Park JW,Kim TW,An SY,Prockop DJ,Lee RH
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue May 09 00:00:00 EDT 2017
Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mice by Selectively Altering the Gut Microbiota and Promoting Intestinal Gamma-Delta T Cells.
Frontiers in pharmacology
Li M,Gao J,Tang Y,Liu M,Wu S,Qu K,Long X,Li H,Liu M,Liu Y,Yuan J,Mao L,Liu Y,Zheng X,Wang E,Wang J,Yang Y
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Sep 30 00:00:00 EDT 2020
Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies.
PloS one
Min M,Yan BX,Wang P,Landeck L,Chen JQ,Li W,Cai SQ,Zheng M,Man XY
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Jan 16 00:00:00 EST 2018
Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.
Oncoimmunology
Huang RY,Francois A,McGray AR,Miliotto A,Odunsi K
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Autophagy is a signature of a signaling network that maintains hematopoietic stem cells.
PloS one
Nguyen-McCarty M,Klein PS
14-0041 was used in Flow cytometry/Cell sorting to identify the downstream effectors of mTORC1 in hematopoietic stem cells.
Fri Sep 15 00:00:00 EDT 2017
Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis.
PloS one
Tornack J,Reece ST,Bauer WM,Vogelzang A,Bandermann S,Zedler U,Stingl G,Kaufmann SH,Melchers F
14-0041-82 was used in Flow Cytometry to conclude that LT-pHSCs, together with MSCs of Mtb-infected humans and mice serve as a hitherto unappreciated quiescent cellular depot for Mtb during latent TB infection.
Tue Sep 05 00:00:00 EDT 2017
Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.
JCI insight
Azzam KM,Madenspacher JH,Cain DW,Lai L,Gowdy KM,Rai P,Janardhan K,Clayton N,Cunningham W,Jensen H,Patel PS,Kearney JF,Taylor GA,Fessler MB
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Aug 17 00:00:00 EDT 2017
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Nature communications
Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Feb 13 00:00:00 EST 2017
A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation.
EBioMedicine
Ma J,Teng X,Wang X,Fan X,Wu Y,Tian M,Zhou Z,Li L
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2017
CD4 T Cell Dependent Colitis Exacerbation Following Re-Exposure of Mycobacterium avium ssp. paratuberculosis.
Frontiers in cellular and infection microbiology
Suwandi A,Bargen I,Pils MC,Krey M,Zur Lage S,Singh AK,Basler T,Falk CS,Seidler U,Hornef MW,Goethe R,Weiss S
14-0041 was used in Immunohistochemistry to reveal the specific ability of MAP to aggravate intestinal inflammation and clinical symptoms.
Tue Sep 19 00:00:00 EDT 2017
Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.
Cell
Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Oct 06 00:00:00 EDT 2016
Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation.
Nature immunology
Monticelli LA,Buck MD,Flamar AL,Saenz SA,Tait Wojno ED,Yudanin NA,Osborne LC,Hepworth MR,Tran SV,Rodewald HR,Shah H,Cross JR,Diamond JM,Cantu E,Christie JD,Pearce EL,Artis D
14-0041 was used in Flow cytometry/Cell sorting to identify Arg1 as a key regulator of group 2 innate lymphoid cell bioenergetics that control proliferative capacity and pro-inflammatory functions.
Wed Jun 01 00:00:00 EDT 2016
Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.
Nature immunology
Gerriets VA,Kishton RJ,Johnson MO,Cohen S,Siska PJ,Nichols AG,Warmoes MO,de Cubas AA,MacIver NJ,Locasale JW,Turka LA,Wells AD,Rathmell JC
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2016
Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.
Circulation research
Sager HB,Hulsmans M,Lavine KJ,Moreira MB,Heidt T,Courties G,Sun Y,Iwamoto Y,Tricot B,Khan OF,Dahlman JE,Borodovsky A,Fitzgerald K,Anderson DG,Weissleder R,Libby P,Swirski FK,Nahrendorf M
14-0041 was used in Flow cytometry/Cell sorting to elucidate the origin and roles of macrophages in the post-myocardial infarction remodelling of nonischaemic remote myocardium.
Fri Sep 16 00:00:00 EDT 2016
Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.
The Journal of clinical investigation
Massaad MJ,Zhou J,Tsuchimoto D,Chou J,Jabara H,Janssen E,Glauzy S,Olson BG,Morbach H,Ohsumi TK,Schmitz K,Kyriacos M,Kane J,Torisu K,Nakabeppu Y,Notarangelo LD,Chouery E,Megarbane A,Kang PB,Al-Idrissi E,Aldhekri H,Meffre E,Mizui M,Tsokos GC,Manis JP,Al-Herz W,Wallace SS,Geha RS
14-0041 was used in Flow cytometry/Cell sorting to investigate alterations in immune cell apoptosis during autoimmunity, showing that deficiency in NEIL3 drives increased predisposition to autoimmunity.
Tue Nov 01 00:00:00 EDT 2016
pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation.
Journal of autoimmunity
Duraes FV,Lippens C,Steinbach K,Dubrot J,Brighouse D,Bendriss-Vermare N,Issazadeh-Navikas S,Merkler D,Hugues S
14-0041 was used in Flow cytometry/Cell sorting to investigate novel pDC-based cell therapies in autoimmune diseases, aiming at specifically modulating pathogenic cells that induce and sustain autoimmune inflammation.
Mon Feb 01 00:00:00 EST 2016
Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa.
Proceedings of the National Academy of Sciences of the United States of America
Oh JE,Kim BC,Chang DH,Kwon M,Lee SY,Kang D,Kim JY,Hwang I,Yu JW,Nakae S,Lee HK
14-0041 was used in Flow cytometry/Cell sorting to provide insight into the mechanisms of homeostasis maintained by commensal bacteria, and reveal a deleterious consequence of dysbiosis in antiviral immune defense.
Tue Feb 09 00:00:00 EST 2016
Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.
Immunology
Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Sat Oct 01 00:00:00 EDT 2016
p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.
European journal of immunology
Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
Multispectral Imaging of T and B Cells in Murine Spleen and Tumor.
Journal of immunology (Baltimore, Md. : 1950)
Feng Z,Jensen SM,Messenheimer DJ,Farhad M,Neuberger M,Bifulco CB,Fox BA
Sun May 01 00:00:00 EDT 2016
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Aug 15 00:00:00 EDT 2016
Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.
Journal of immunology (Baltimore, Md. : 1950)
Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA
14-0041 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.
Tue Nov 15 00:00:00 EST 2016
Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.
Journal of immunology (Baltimore, Md. : 1950)
Poczobutt JM,Nguyen TT,Hanson D,Li H,Sippel TR,Weiser-Evans MC,Gijon M,Murphy RC,Nemenoff RA
14-0041 was used in Flow cytometry/Cell sorting to reveal an antitumorigenic role for 5-LO products in the microenvironment during lung cancer progression through T cell regulation.
Fri Jan 15 00:00:00 EST 2016
Exaggerated IL-15 and Altered Expression of foxp3+ Cell-Derived Cytokines Contribute to Enhanced Colitis in Nlrp3-/- Mice.
Mediators of inflammation
Hirota SA,Ueno A,Tulk SE,Becker HM,Schenck LP,Potentier MS,Li Y,Ghosh S,Muruve DA,MacDonald JA,Beck PL
14-0041 was used in Flow cytometry/Cell sorting to suggest that the NLRP3 inflammasome can regulate intestinal inflammation through noncanonical mechanisms.
Mon Jun 05 00:00:00 EDT 2017
Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.
Molecular medicine reports
Gu L,Deng WS,Sun XF,Zhou H,Xu Q
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.
Biology open
Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Sun May 15 00:00:00 EDT 2016
Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.
Nature communications
Brinkman CC,Iwami D,Hritzo MK,Xiong Y,Ahmad S,Simon T,Hippen KL,Blazar BR,Bromberg JS
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Jun 21 00:00:00 EDT 2016
Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.
Nature communications
Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Jun 08 00:00:00 EDT 2016
In vitro Differentiation of Murine Innate Lymphoid Cells from Common Lymphoid Progenitor Cells.
Bio-protocol
Seehus C,Kaye J
14004182 was used in flow cytometry to detail how to obtain innate lymphoid cells from isolated common lymphoid progenitors
Sun Mar 20 00:00:00 EDT 2016
Interleukin-10 deficiency impairs regulatory T cell-derived neuropilin-1 functions and promotes Th1 and Th17 immunity.
Scientific reports
Wang S,Gao X,Shen G,Wang W,Li J,Zhao J,Wei YQ,Edwards CK
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Apr 14 00:00:00 EDT 2016
NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.
Nature communications
Alrefai H,Muhammad K,Rudolf R,Pham DA,Klein-Hessling S,Patra AK,Avots A,Bukur V,Sahin U,Tenzer S,Goebeler M,Kerstan A,Serfling E
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed May 25 00:00:00 EDT 2016
Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice.
BMC complementary and alternative medicine
Zhang S,Liu X,Mei L,Wang H,Fang F
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Aug 31 00:00:00 EDT 2016
Flagellin is a strong vaginal adjuvant of a therapeutic vaccine for genital cancer.
Oncoimmunology
Lee SE,Hong SH,Verma V,Lee YS,Duong TN,Jeong K,Uthaman S,Sung YC,Lee JT,Park IK,Min JJ,Rhee JH
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2016
Essential Contribution of CD4+ T Cells to Antigen-Induced Nasal Hyperresponsiveness in Experimental Allergic Rhinitis.
PloS one
Nishimura T,Kaminuma O,Saeki M,Kitamura N,Matsuoka K,Yonekawa H,Mori A,Hiroi T
14-0041 was used in Functional assays to demonstrate that CD4+ T-cells are crucial in the pathogenesis of allergic rhinitis via induction of nasal hyperresponsiveness.
Mon Jul 04 00:00:00 EDT 2016
A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms.
Cell reports
Choi IY,Piccio L,Childress P,Bollman B,Ghosh A,Brandhorst S,Suarez J,Michalsen A,Cross AH,Morgan TE,Wei M,Paul F,Bock M,Longo VD
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Jun 07 00:00:00 EDT 2016
Conditions for the generation of cytotoxic CD4(+) Th cells that enhance CD8(+) CTL-mediated tumor regression.
Clinical & translational immunology
Li K,Baird M,Yang J,Jackson C,Ronchese F,Young S
14-0041 was used in Flow cytometry/Cell sorting to provide valuable data for further research into in vitro expansion of CD4(+) Th1-like cells, with potential applications to cancer treatment involving ACT.
Mon Aug 01 00:00:00 EDT 2016
TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection.
Cell reports
Schleicher U,Paduch K,Debus A,Obermeyer S,König T,Kling JC,Ribechini E,Dudziak D,Mougiakakos D,Murray PJ,Ostuni R,Körner H,Bogdan C
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue May 03 00:00:00 EDT 2016
Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent.
eLife
Westernberg L,Conche C,Huang YH,Rigaud S,Deng Y,Siegemund S,Mukherjee S,Nosaka L,Das J,Sauer K
14-0041 was used in Flow cytometry/Cell sorting to elucidate the mechanisms underlying the establishment of the Notch-dependent nature of β-selection.
Thu Feb 11 00:00:00 EST 2016
Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction.
Nature communications
Cruz AC,Ramaswamy M,Ouyang C,Klebanoff CA,Sengupta P,Yamamoto TN,Meylan F,Thomas SK,Richoz N,Eil R,Price S,Casellas R,Rao VK,Lippincott-Schwartz J,Restifo NP,Siegel RM
14-0041 was used in Functional assays to elucidate how palmitoylation defects in the Fas/CD95 receptor impact primary immune cells.
Fri Dec 23 00:00:00 EST 2016
Fas/CD95 prevents autoimmunity independently of lipid raft localization and efficient apoptosis induction.
Nature communications
Cruz AC,Ramaswamy M,Ouyang C,Klebanoff CA,Sengupta P,Yamamoto TN,Meylan F,Thomas SK,Richoz N,Eil R,Price S,Casellas R,Rao VK,Lippincott-Schwartz J,Restifo NP,Siegel RM
14-0041 was used in Functional assays to elucidate how palmitoylation defects in the Fas/CD95 receptor impact primary immune cells.
Fri Dec 23 00:00:00 EST 2016
PD-1 pathway-mediated regulation of islet-specific CD4+ T cell subsets in autoimmune diabetes.
Immunoendocrinology (Houston, Tex.)
Martinov T,Spanier JA,Pauken KE,Fife BT
14-0041 was used in Flow cytometry/Cell sorting to understand the role of PD-1 in maintaining islet-specific tolerance in diabetes-resistant strains.
Wed Mar 30 00:00:00 EDT 2022
Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.
Scientific reports
Ochi T,Feng Y,Kitamoto S,Nagao-Kitamoto H,Kuffa P,Atarashi K,Honda K,Teitelbaum DH,Kamada N
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Jun 15 00:00:00 EDT 2016
CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Nature
Huang YH,Zhu C,Kondo Y,Anderson AC,Gandhi A,Russell A,Dougan SK,Petersen BS,Melum E,Pertel T,Clayton KL,Raab M,Chen Q,Beauchemin N,Yazaki PJ,Pyzik M,Ostrowski MA,Glickman JN,Rudd CE,Ploegh HL,Franke A,Petsko GA,Kuchroo VK,Blumberg RS
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Jan 15 00:00:00 EST 2015
Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.
Nature biotechnology
Kim J,Li WA,Choi Y,Lewin SA,Verbeke CS,Dranoff G,Mooney DJ
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Jan 01 00:00:00 EST 2015
Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner.
Blood
Yi W,Hu X,Chen Z,Liu L,Tian Y,Chen H,Cong YS,Yang F,Zhang L,Rudolph KL,Zhang Z,Zhao Y,Ju Z
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Jul 30 00:00:00 EDT 2015
Bcl11b is essential for group 2 innate lymphoid cell development.
The Journal of experimental medicine
Walker JA,Oliphant CJ,Englezakis A,Yu Y,Clare S,Rodewald HR,Belz G,Liu P,Fallon PG,McKenzie AN
14-0041 was used in Flow cytometry/Cell sorting to study the role of Bcl11b in the differentiation of group 2 innate lymphoid cells.
Mon Jun 01 00:00:00 EDT 2015
IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.
The Journal of experimental medicine
Pallangyo CK,Ziegler PK,Greten FR
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Dec 14 00:00:00 EST 2015
Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo.
Science advances
Hoffmann MM,Molina-Mendiola C,Nelson AD,Parks CA,Reyes EE,Hansen MJ,Rajagopalan G,Pease LR,Schrum AG,Gil D
14-0041 was used in Flow cytometry/Cell sorting to investigate co-potentiation, showing that weak T-cell responses can be boosted to provide immunotherapy in vivo.
Thu Oct 01 00:00:00 EDT 2015
Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases.
The Journal of allergy and clinical immunology
Russell SL,Gold MJ,Reynolds LA,Willing BP,Dimitriu P,Thorson L,Redpath SA,Perona-Wright G,Blanchet MR,Mohn WW,Finlay BB,McNagny KM
14-0041 was used in Immunofluorescence to assess the effect of perinatal exposure to antibiotics on the severity of Saccharopolyspora rectivirgula infection.
Thu Jan 01 00:00:00 EST 2015
Adaptive Immune Regulation of Mammary Postnatal Organogenesis.
Developmental cell
Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Sep 14 00:00:00 EDT 2015
Adaptive Immune Regulation of Mammary Postnatal Organogenesis.
Developmental cell
Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Sep 14 00:00:00 EDT 2015
B cell autophagy mediates TLR7-dependent autoimmunity and inflammation.
Autophagy
Weindel CG,Richey LJ,Bolland S,Mehta AJ,Kearney JF,Huber BT
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry
Mon Apr 18 00:00:00 EDT 2016
β-catenin promotes regulatory T-cell responses in tumors by inducing vitamin A metabolism in dendritic cells.
Cancer research
Hong Y,Manoharan I,Suryawanshi A,Majumdar T,Angus-Hill ML,Koni PA,Manicassamy B,Mellor AL,Munn DH,Manicassamy S
14-0041 was used in Flow cytometry/Cell sorting to show that dendritic cells in the tumour microenvironment acquire the ability to metabolise vitamin A to produce retinoic acid, driving immune tolerance.
Sun Feb 15 00:00:00 EST 2015
IFN-γ ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation.
Proceedings of the National Academy of Sciences of the United States of America
Sosa RA,Murphey C,Robinson RR,Forsthuber TG
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunofluorescence
Tue Sep 08 00:00:00 EDT 2015
Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
Cell death and differentiation
Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.
PLoS biology
Gallego-Ortega D,Ledger A,Roden DL,Law AM,Magenau A,Kikhtyak Z,Cho C,Allerdice SL,Lee HJ,Valdes-Mora F,Herrmann D,Salomon R,Young AI,Lee BY,Sergio CM,Kaplan W,Piggin C,Conway JR,Rabinovich B,Millar EK,Oakes SR,Chtanova T,Swarbrick A,Naylor MJ,O'Toole S,Green AR,Timpson P,Gee JM,Ellis IO,Clark SJ,Ormandy CJ
14-0041 was used in Flow cytometry/Cell sorting to implicate ELF5 as a defining factor in the acquisition of the key aspects of the lethal phenotype in luminal A breast cancer.
Tue Dec 01 00:00:00 EST 2015
A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine.
Mucosal immunology
Dunne A,Mielke LA,Allen AC,Sutton CE,Higgs R,Cunningham CC,Higgins SC,Mills KH
14-0041 was used in Flow cytometry/Cell sorting to investigate the identification and characterisation of novel TLR2-activating lipoproteins from B. pertussis.
Fri May 01 00:00:00 EDT 2015
Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice.
Mucosal immunology
Bertin S,Lozano-Ruiz B,Bachiller V,García-Martínez I,Herdman S,Zapater P,Francés R,Such J,Lee J,Raz E,González-Navajas JM
14-0041 was used in Flow cytometry/Cell sorting to demonstrate that DUSP6 regulates CD4+ T-cell activation and differentiation by inhibiting TCR-dependent ERK1/2 activation.
Fri May 01 00:00:00 EDT 2015
Mice lacking Axl and Mer tyrosine kinase receptors are susceptible to experimental autoimmune orchitis induction.
Immunology and cell biology
Li N,Liu Z,Zhang Y,Chen Q,Liu P,Cheng CY,Lee WM,Chen Y,Han D
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Sun Mar 01 00:00:00 EST 2015
Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection.
Journal of immunology (Baltimore, Md. : 1950)
Sun C,Schattgen SA,Pisitkun P,Jorgensen JP,Hilterbrand AT,Wang LJ,West JA,Hansen K,Horan KA,Jakobsen MR,O'Hare P,Adler H,Sun R,Ploegh HL,Damania B,Upton JW,Fitzgerald KA,Paludan SR
14-0041 was used in Flow cytometry/Cell sorting to report that murine gammaherpesvirus 68 induces very limited innate immune responses through DNA-stimulated pathways.
Sun Feb 15 00:00:00 EST 2015
Cellular Dynamics of Memory B Cell Populations: IgM+ and IgG+ Memory B Cells Persist Indefinitely as Quiescent Cells.
Journal of immunology (Baltimore, Md. : 1950)
Jones DD,Wilmore JR,Allman D
14-0041 was used in Flow cytometry/Cell sorting to demonstrate that once established, both IgG-positive and less frequent IgM-positive memory populations are exceptionally stable, with little evidence of attrition or cellular turnover.
Sun Nov 15 00:00:00 EST 2015
B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses.
Journal of immunology (Baltimore, Md. : 1950)
Pone EJ,Lam T,Lou Z,Wang R,Chen Y,Liu D,Edinger AL,Xu Z,Casali P
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2015
Histone deacetylation of memory T lymphocytes by You-Gui-Wan alleviates allergen-induced eosinophilic airway inflammation in asthma.
Chinese medicine
Zhang HP,Fu JJ,Fan T,Zhang WB,Wang ZL,Wang L,Wang G
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Jun 15 00:00:00 EDT 2015
Batf3 deficiency is not critical for the generation of CD8α⁺ dendritic cells.
Immunobiology
Mott KR,Maazi H,Allen SJ,Zandian M,Matundan H,Ghiasi YN,Sharifi BG,Underhill D,Akbari O,Ghiasi H
14-0041 was used in Immunohistochemistry to demonstrate that Batf3-/- mice express CD8α + dendritic cells without any known infection.
Wed Apr 01 00:00:00 EDT 2015
dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.
Nature communications
Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Sep 15 00:00:00 EDT 2015
dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.
Nature communications
Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Sep 15 00:00:00 EDT 2015
ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy.
Nature communications
Albright RA,Stabach P,Cao W,Kavanagh D,Mullen I,Braddock AA,Covo MS,Tehan M,Yang G,Cheng Z,Bouchard K,Yu ZX,Thorn S,Wang X,Folta-Stogniew EJ,Negrete A,Sinusas AJ,Shiloach J,Zubal G,Madri JA,De La Cruz EM,Braddock DT
14-0041 was used in Functional assays to investigate treatment options for generalized arterial calcification of infancy.
Tue Dec 01 00:00:00 EST 2015
Chronic Trichuris muris Infection in C57BL/6 Mice Causes Significant Changes in Host Microbiota and Metabolome: Effects Reversed by Pathogen Clearance.
PloS one
Houlden A,Hayes KS,Bancroft AJ,Worthington JJ,Wang P,Grencis RK,Roberts IS
14-0041 was used in Flow cytometry/Cell sorting to investigate the effects of T. muris infection on the faecal microbiota of mice.
Wed Apr 06 00:00:00 EDT 2016
Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells.
Nature communications
Gao Y,Yang P,Shen H,Yu H,Song X,Zhang L,Zhang P,Cheng H,Xie Z,Hao S,Dong F,Ma S,Ji Q,Bartlow P,Ding Y,Wang L,Liu H,Li Y,Cheng H,Miao W,Yuan W,Yuan Y,Cheng T,Xie XQ
14-0041 was used in Flow cytometry/Cell sorting to investigate how putative small-molecule inhibitors for p18 protein are valuable for further dissecting the signalling pathways of stem cell self-renewal.
Wed Feb 18 00:00:00 EST 2015
Mannan-modified adenovirus targeting TERT and VEGFR-2: A universal tumour vaccine.
Scientific reports
Wang Y,Zhang J,Wu Y,Ding ZY,Luo XM,Liu J,Zhong WN,Deng GH,Xia XY,Deng YT,Wei YQ,Jiang Y
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Jun 18 00:00:00 EDT 2015
Mechanisms of immunity in post-exposure vaccination against Ebola virus infection.
PloS one
Bradfute SB,Anthony SM,Stuthman KS,Ayithan N,Tailor P,Shaia CI,Bray M,Ozato K,Bavari S
14-0041 was used in Functional assays to analyse the expression levels of various cytokines in the serum of mice given an Ebola virus-like particle.
Tue Feb 23 00:00:00 EST 2016
Intranasal Administration of Lentiviral miR-135a Regulates Mast Cell and Allergen-Induced Inflammation by Targeting GATA-3.
PloS one
Deng YQ,Yang YQ,Wang SB,Li F,Liu MZ,Hua QQ,Tao ZZ
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue May 31 00:00:00 EDT 2016
Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses.
Stem cell reports
Wang WB,Yen ML,Liu KJ,Hsu PJ,Lin MH,Chen PM,Sudhir PR,Chen CH,Chen CH,Sytwu HK,Yen BL
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Sep 08 00:00:00 EDT 2015
Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint.
PloS one
Tamehiro N,Oda H,Shirai M,Suzuki H
14-0041 was used in Flow cytometry/Cell sorting to indicate that an excess amount of RhoH is able to initiate pre-TCR signalling in the absence of pre-TCR complexes.
Mon Apr 25 00:00:00 EDT 2016
Protection against H5N1 Influenza Virus Induced by Matrix-M Adjuvanted Seasonal Virosomal Vaccine in Mice Requires Both Antibodies and T Cells.
PloS one
Cox F,Baart M,Huizingh J,Tolboom J,Dekking L,Goudsmit J,Saeland E,Radošević K
14-0041 was used in Functional assays to investigate the contribution of humoral and cellular immune responses to heterosubtypic protection against H5N1 induced by a Matrix-M adjuvanted seasonal influenza vaccine.
Fri Jun 24 00:00:00 EDT 2016
Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction.
Nature communications
Rouhani SJ,Eccles JD,Riccardi P,Peske JD,Tewalt EF,Cohen JN,Liblau R,Mäkinen T,Engelhard VH
14-0041 was used in Flow cytometry/Cell sorting to demonstrate that when β-galactosidase (β-gal) is expressed in LECs, β-gal-specific CD8 T cells undergo deletion via the PD-1/PD-L1 and LAG-3/MHC-II pathways.
Fri Apr 10 00:00:00 EDT 2015
Disease severity and mortality can be independently regulated in a mouse model of experimental graft versus host disease.
PloS one
Galvani RG,Lemos R,Areal RB,Salvador PA,Zamboni DS,Wanderley JL,Bonomo A
14-0041 was used in Flow cytometry/Cell sorting to investigate the exact cause of death in graft versus host disease, showing that disease severity and mortality can be independently regulated.
Mon Oct 19 00:00:00 EDT 2015
A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.
Nature medicine
Herranz D,Ambesi-Impiombato A,Palomero T,Schnell SA,Belver L,Wendorff AA,Xu L,Castillo-Martin M,Llobet-Navás D,Cordon-Cardo C,Clappier E,Soulier J,Ferrando AA
14-0041 was used in Flow cytometry/Cell sorting to identify N-Me as a long-range oncogenic enhancer implicated directly in the pathogenesis of human leukaemia.
Wed Oct 01 00:00:00 EDT 2014
The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells.
Nature immunology
Xiao N,Eto D,Elly C,Peng G,Crotty S,Liu YC
14-0041 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms that regulate the induction of T(FH) cells, showing that Itch is required.
Tue Jul 01 00:00:00 EDT 2014
In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.
Blood
Derderian SC,Togarrati PP,King C,Moradi PW,Reynaud D,Czechowicz A,Weissman IL,MacKenzie TC
14-0041 was used in Flow cytometry/Cell sorting to develop a successful foetal conditioning strategy associated with minimal toxicity.
Thu Aug 07 00:00:00 EDT 2014
Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.
The Journal of clinical investigation
Kong G,Wunderlich M,Yang D,Ranheim EA,Young KH,Wang J,Chang YI,Du J,Liu Y,Tey SR,Zhang X,Juckett M,Mattison R,Damnernsawad A,Zhang J,Mulloy JC,Zhang J
14-0041 was used in Flow cytometry/Cell sorting to investigate the effect of combined targeting of MEK/ERK and JAK/STAT signalling on the murine myeloproliferative neoplasm.
Sun Jun 01 00:00:00 EDT 2014
Intrinsic TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition.
The Journal of clinical investigation
Bhadra R,Moretto MM,Castillo JC,Petrovas C,Ferrando-Martinez S,Shokal U,Leal M,Koup RA,Eleftherianos I,Khan IA
14-0041 was used in Flow cytometry/Cell sorting to investigate the progressive loss of CD8+ T cell polyfunctionality during aging, using animals challenged with the obligate intracellular pathogen Encephalitozoon cuniculi.
Sun Jun 01 00:00:00 EDT 2014
Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.
EMBO molecular medicine
Basler M,Mundt S,Muchamuel T,Moll C,Jiang J,Groettrup M,Kirk CJ
14-0041 was used in Flow cytometry/Cell sorting to investigate the therapeutic efficacy of an immunoproteasome inhibitor, ONX 0914, in two different mouse models of multiple sclerosis.
Sat Feb 01 00:00:00 EST 2014
Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.
Autophagy
Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Jul 01 00:00:00 EDT 2014
Diacylglycerol kinase α establishes T cell polarity by shaping diacylglycerol accumulation at the immunological synapse.
Science signaling
Chauveau A,Le Floc'h A,Bantilan NS,Koretzky GA,Huse M
14-0041 was used in Immunofluorescence to reveal a previously unappreciated function of DGK-α and provide insight into the mechanisms that determine lymphocyte polarity.
Tue Aug 26 00:00:00 EDT 2014
Requirement for interactions of natural killer T cells and myeloid-derived suppressor cells for transplantation tolerance.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Hongo D,Tang X,Baker J,Engleman EG,Strober S
14-0041 was used in Flow cytometry/Cell sorting to investigate the cellular and molecular mechanisms required for suitable immune tolerance for combined bone marrow and heart transplant acceptance in mice.
Sat Nov 01 00:00:00 EDT 2014
Dietary supplementation with high doses of regular vitamin D3 safely reduces diabetes incidence in NOD mice when given early and long term.
Diabetes
Takiishi T,Ding L,Baeke F,Spagnuolo I,Sebastiani G,Laureys J,Verstuyf A,Carmeliet G,Dotta F,Van Belle TL,Gysemans CA,Mathieu C
14-0041 was used in Flow cytometry/Cell sorting to investigate the effect of vitamin D3 administration during different periods of life on diabetes prevention in NOD mice.
Sun Jun 01 00:00:00 EDT 2014
Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.
PLoS pathogens
Ataide MA,Andrade WA,Zamboni DS,Wang D,Souza Mdo C,Franklin BS,Elian S,Martins FS,Pereira D,Reed G,Fitzgerald KA,Golenbock DT,Gazzinelli RT
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2014
Few Foxp3⁺ regulatory T cells are sufficient to protect adult mice from lethal autoimmunity.
European journal of immunology
Mayer CT,Ghorbani P,Kühl AA,Stüve P,Hegemann M,Berod L,Gershwin ME,Sparwasser T
14-0041 was used in Flow cytometry/Cell sorting to study the mechanisms underlying why regulatory T cell-depletion fails to cause autoimmunity in adult Depletion of REGulatory T cells mice.
Wed Oct 01 00:00:00 EDT 2014
Internalization and TLR-dependent type I interferon production by monocytes in response to Toxoplasma gondii.
Immunology and cell biology
Han SJ,Melichar HJ,Coombes JL,Chan SW,Koshy AA,Boothroyd JC,Barton GM,Robey EA
14-0041 was used in Flow cytometry/Cell sorting to show that inflammatory monocytes, but not neutrophils, produce IFN-β in response to T. gondii infection.
Sat Nov 01 00:00:00 EDT 2014
IRF4 in dendritic cells inhibits IL-12 production and controls Th1 immune responses against Leishmania major.
Journal of immunology (Baltimore, Md. : 1950)
Akbari M,Honma K,Kimura D,Miyakoda M,Kimura K,Matsuyama T,Yui K
14-0041 was used in Flow cytometry/Cell sorting to investigate the roles of the transcription factor IRF4 in dendritic cells and macrophages in vivo.
Sat Mar 01 00:00:00 EST 2014
Innate immune cell CD45 regulates lymphopenia-induced T cell proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Saunders AE,Shim YA,Johnson P
14-0041 was used in Flow cytometry/Cell sorting to demonstrate a novel role for CD45 on innate immune cells in promoting lymphopenia-induced T cell proliferation.
Mon Sep 15 00:00:00 EDT 2014
Regulation of cyp26a1 on Th17 cells in mouse peri-implantation.
Journal of cellular and molecular medicine
Liu HY,Chao H,Liu ZK,Xia HF,Song Z,Yang Y,Peng JP
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Sat Mar 01 00:00:00 EST 2014
Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.
Human vaccines & immunotherapeutics
Wang S,Wu B,Xue J,Wang M,Chen R,Wang B
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Jan 05 00:00:00 EST 2015
High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu May 01 00:00:00 EDT 2014
Somatostatin inhibits the production of interferon-γ by intestinal epithelial cells during intestinal ischemia-reperfusion in macaques.
Digestive diseases and sciences
Liu L,Tan Q,Hu B,Wu H,Wang C,Tang C
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry
Wed Oct 01 00:00:00 EDT 2014
Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects.
BMC cancer
Tian H,Shi G,Yang G,Zhang J,Li Y,Du T,Wang J,Xu F,Cheng L,Zhang X,Dai L,Chen X,Zhang S,Yang Y,Yu D,Wei Y,Deng H
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Jan 29 00:00:00 EST 2014
Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects.
BMC cancer
Tian H,Shi G,Yang G,Zhang J,Li Y,Du T,Wang J,Xu F,Cheng L,Zhang X,Dai L,Chen X,Zhang S,Yang Y,Yu D,Wei Y,Deng H
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Jan 29 00:00:00 EST 2014
A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking β-glucans.
PloS one
Dong B,Li D,Li R,Chen SC,Liu W,Liu W,Chen L,Chen Y,Zhang X,Tong Z,Xia Y,Xia P,Wang Y,Duan Y
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Mon Sep 28 00:00:00 EDT 2015
Toll-like receptor 9 agonist enhances anti-tumor immunity and inhibits tumor-associated immunosuppressive cells numbers in a mouse cervical cancer model following recombinant lipoprotein therapy.
Molecular cancer
Chang LS,Leng CH,Yeh YC,Wu CC,Chen HW,Huang HM,Liu SJ
14-0041 was used in Functional assays to assess the anti-tumour efficacy of a combination therapy of TLR9 agonist and rlipo-E7m.
Wed Mar 19 00:00:00 EDT 2014
The spleen responds to intestinal manipulation but does not participate in the inflammatory response in a mouse model of postoperative ileus.
PloS one
Costes LM,van der Vliet J,Farro G,Matteoli G,van Bree SH,Olivier BJ,Nolte MA,Boeckxstaens GE,Cailotto C
14-0041 was used in Flow cytometry/Cell sorting to demonstrate that intestinal manipulation results in two distinct phenomena: local intestinal inflammation and a decrease in splenic cellularity.
Fri Nov 06 00:00:00 EST 2015
Epigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming.
Nature communications
Harland KL,Day EB,Apte SH,Russ BE,Doherty PC,Turner SJ,Kelso A
14-0041 was used in Flow cytometry/Cell sorting to study whether epigenetic modifications affecting T-cells persist following adoptive transfer of the cells.
Fri Mar 28 00:00:00 EDT 2014
Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis.
PloS one
May SL,Zhou Q,Lewellen M,Carter CM,Coffey D,Highfill SL,Bucher CM,Matise I,Morse HC,O'Sullivan MG,Schutten M,Johnson C,Bellgrau D,Blazar BR,Modiano JF
14-0041 was used in Flow cytometry/Cell sorting to study how Nfatc2 and Tob1 are non-redundant regulators of lymphocyte homeostasis.
Mon Oct 19 00:00:00 EDT 2015
CD8α dendritic cells drive establishment of HSV-1 latency.
PloS one
Mott KR,Allen SJ,Zandian M,Konda B,Sharifi BG,Jones C,Wechsler SL,Town T,Ghiasi H
14-0041 was used in Immunohistochemistry to investigate the impact of CD8α dendritic cells on HSV-1 latency in mice.
Tue Jan 20 00:00:00 EST 2015
CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.
eLife
Linterman MA,Denton AE,Divekar DP,Zvetkova I,Kane L,Ferreira C,Veldhoen M,Clare S,Dougan G,Espéli M,Smith KG
14-0041 was used in Flow cytometry/Cell sorting to determine the role for CD28 after T cell priming.
Mon Oct 27 00:00:00 EDT 2014
Innate signaling promotes formation of regulatory nitric oxide-producing dendritic cells limiting T-cell expansion in experimental autoimmune myocarditis.
Circulation
Kania G,Siegert S,Behnke S,Prados-Rosales R,Casadevall A,Lüscher TF,Luther SA,Kopf M,Eriksson U,Blyszczuk P
14-0041 was used in Flow cytometry/Cell sorting to investigate how activation of innate pattern-recognition receptors is critical not only for disease induction but also for counterregulatory mechanisms, protecting the heart from exaggerated autoimmunity.
Tue Jun 11 00:00:00 EDT 2013
Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells.
Nature immunology
Cohen NR,Brennan PJ,Shay T,Watts GF,Brigl M,Kang J,Brenner MB
14-0041 was used in Flow cytometry/Cell sorting to profile gene expression in invariant natural killer T cells during ontogeny and in peripheral subsets.
Tue Jan 01 00:00:00 EST 2013
CD40L expression permits CD8+ T cells to execute immunologic helper functions.
Blood
Frentsch M,Stark R,Matzmohr N,Meier S,Durlanik S,Schulz AR,Stervbo U,Jürchott K,Gebhardt F,Heine G,Reuter MA,Betts MR,Busch D,Thiel A
14-0041 was used in Flow cytometry/Cell sorting to investigate the role of CD40L in CD8+ T cells, showing that expression permits CD8+ T cells to execute immunologic helper functions.
Thu Jul 18 00:00:00 EDT 2013
Mesenchymal stem cells attenuate ischemic acute kidney injury by inducing regulatory T cells through splenocyte interactions.
Kidney international
Hu J,Zhang L,Wang N,Ding R,Cui S,Zhu F,Xie Y,Sun X,Wu D,Hong Q,Li Q,Shi S,Liu X,Chen X
14-0041 was used in Flow cytometry/Cell sorting to study how mesenchymal stem cells ameliorate ischemic acute kidney injury by inducing regulatory T cells through interactions with splenocytes.
Sun Sep 01 00:00:00 EDT 2013
HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.
The Journal of experimental medicine
Gautier EL,Westerterp M,Bhagwat N,Cremers S,Shih A,Abdel-Wahab O,Lütjohann D,Randolph GJ,Levine RL,Tall AR,Yvan-Charvet L
14-0041 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms leading to high metabolic rate in myeloproliferative disorders, showing that HDL and Glut1 inhibition reverse hypermetabolic state.
Mon Feb 11 00:00:00 EST 2013
Interleukin-6-signal transducer and activator of transcription-3 signaling mediates aortic dissections induced by angiotensin II via the T-helper lymphocyte 17-interleukin 17 axis in C57BL/6 mice.
Arteriosclerosis, thrombosis, and vascular biology
Ju X,Ijaz T,Sun H,Ray S,Lejeune W,Lee C,Recinos A,Guo DC,Milewicz DM,Tilton RG,Brasier AR
14-0041 was used in Flow cytometry/Cell sorting to suggest that the Th17-IL-17 axis is an important effector arm of Ang II-mediated vascular inflammation.
Mon Jul 01 00:00:00 EDT 2013
Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity.
PLoS pathogens
Worthington JJ,Klementowicz JE,Rahman S,Czajkowska BI,Smedley C,Waldmann H,Sparwasser T,Grencis RK,Travis MA
14-0041 was used in Flow cytometry/Cell sorting to describe a novel cellular and molecular pathway involved in the development of chronic intestinal parasite infection.
Mon May 26 00:00:00 EDT 2014
IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
PLoS pathogens
Schmitz I,Schneider C,Fröhlich A,Frebel H,Christ D,Leonard WJ,Sparwasser T,Oxenius A,Freigang S,Kopf M
14-0041 was used in Flow cytometry/Cell sorting to investigate the role of Foxp3+ regulatory T (Treg) cells during viral infections, showing that IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
Mon Dec 09 00:00:00 EST 2013
Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.
Development (Cambridge, England)
Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Feb 01 00:00:00 EST 2013
A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).
Disease models & mechanisms
Carofino BL,Ayanga B,Justice MJ
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Nov 01 00:00:00 EDT 2013
Interferon gamma causes olfactory dysfunction without concomitant neuroepithelial damage.
International forum of allergy & rhinology
Pozharskaya T,Lane AP
14-0041 was used in Immunohistochemistry to investigate the direct effect of IFN-γ on olfactory neuron function that may underlie olfactory loss in CRSsNP or viral infections.
Fri Nov 01 00:00:00 EDT 2013
Intrinsic molecular factors cause aberrant expansion of the splenic marginal zone B cell population in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950)
Stolp J,Mariño E,Batten M,Sierro F,Cox SL,Grey ST,Silveira PA
14-0041 was used in Flow cytometry/Cell sorting to investigate the underlying causes of augmented marginal zone B cell production in NOD mice.
Mon Jul 01 00:00:00 EDT 2013
The influence of T cell Ig mucin-3 signaling on central nervous system autoimmune disease is determined by the effector function of the pathogenic T cells.
Journal of immunology (Baltimore, Md. : 1950)
Lee SY,Goverman JM
14-0041 was used in Flow cytometry/Cell sorting to analyse the role of Tim-3 signalling within various innate immune cells on the development of experimental autoimmune encephalomyelitis.
Wed May 15 00:00:00 EDT 2013
Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice.
Human vaccines & immunotherapeutics
Wu B,Zou Q,Hu Y,Wang B
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2013
Interleukin-6 expands homeostatic space for peripheral T cells.
Cytokine
Hong C,Nam AS,Keller HR,Ligons DL,Park JY,Yoon HW,Park JJ,Luckey MA,Park JH
14-0041 was used in Flow cytometry/Cell sorting to investigate whether IL-6 promotes T cell survival and homeostasis in vivo, showing that it expands homeostatic space for peripheral T cells.
Fri Nov 01 00:00:00 EDT 2013
The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine.
PloS one
Radulovic K,Rossini V,Manta C,Holzmann K,Kestler HA,Niess JH
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Jan 23 00:00:00 EST 2014
The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine.
PloS one
Radulovic K,Rossini V,Manta C,Holzmann K,Kestler HA,Niess JH
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Jan 23 00:00:00 EST 2014
Enhanced immune response against HIV-1 induced by a heterologous DNA prime-adenovirus boost vaccination using mannosylated polyethyleneimine as DNA vaccine adjuvant.
International journal of nanomedicine
Li M,Jiang Y,Xu C,Zhang Z,Sun X
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Wed Apr 02 00:00:00 EDT 2014
T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells.
PloS one
Li G,Yang Q,Zhu Y,Wang HR,Chen X,Zhang X,Lu B
14-0041 was used in Flow cytometry/Cell sorting to investigate the role of T-bet and Eomes in shaping the memory T cell pool.
Tue Oct 10 00:00:00 EDT 2017
Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.
PloS one
Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Jul 31 00:00:00 EDT 2014
Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo.
PloS one
Duarte JH,Di Meglio P,Hirota K,Ahlfors H,Stockinger B
14-0041 was used in Flow cytometry/Cell sorting to study how the immuno-modulatory effect of TCDD administration for EAE is not the consequence of de novo Treg generation, but the inhibition of Th17 cell differentiation.
Tue Aug 12 00:00:00 EDT 2014
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice.
Nature
Devkota S,Wang Y,Musch MW,Leone V,Fehlner-Peach H,Nadimpalli A,Antonopoulos DA,Jabri B,Chang EB
14-0041 was used in Flow cytometry/Cell sorting to show that different dietary fat change the conditions for microbial assemblage in the digestive system in a T helper 1 cell dependent manner.
Thu Jul 05 00:00:00 EDT 2012
The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development.
Immunity
Kageyama R,Cannons JL,Zhao F,Yusuf I,Lao C,Locci M,Schwartzberg PL,Crotty S
14-0041 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the defects in humoural immunity present in humans and mice deficient in the adaptor protein, SAP.
Fri Jun 29 00:00:00 EDT 2012
Prostaglandin E2 suppresses antifungal immunity by inhibiting interferon regulatory factor 4 function and interleukin-17 expression in T cells.
Immunity
Valdez PA,Vithayathil PJ,Janelsins BM,Shaffer AL,Williamson PR,Datta SK
14-0041 was used in Flow cytometry/Cell sorting to study the effect of prostaglandin E2 on the function of Th17 cells during differentiation.
Fri Apr 20 00:00:00 EDT 2012
Molecular definition of the identity and activation of natural killer cells.
Nature immunology
Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL
14-0041 was used in Flow cytometry/Cell sorting to systematically define the transcriptome of mouse natural killer cells in several contexts.
Mon Oct 01 00:00:00 EDT 2012
Tryptophan hydroxylase-1 regulates immune tolerance and inflammation.
The Journal of experimental medicine
Nowak EC,de Vries VC,Wasiuk A,Ahonen C,Bennett KA,Le Mercier I,Ha DG,Noelle RJ
14-0041 was used in Flow cytometry/Cell sorting to investigate the role of Tph-1 in regulation of immunity.
Mon Oct 22 00:00:00 EDT 2012
An in vivo immunotherapy screen of costimulatory molecules identifies Fc-OX40L as a potent reagent for the treatment of established murine gliomas.
Clinical cancer research : an official journal of the American Association for Cancer Research
Murphy KA,Lechner MG,Popescu FE,Bedi J,Decker SA,Hu P,Erickson JR,O'Sullivan MG,Swier L,Salazar AM,Olin MR,Epstein AL,Ohlfest JR
14-0041 was used in Flow cytometry/Cell sorting to investigate the combination of a tumor lysate vaccine with a panel of costimulatory molecules for treatment of gliomas.
Sat Sep 01 00:00:00 EDT 2012
Immune response is an important aspect of the antitumor effect produced by a CD40L-encoding oncolytic adenovirus.
Cancer research
Diaconu I,Cerullo V,Hirvinen ML,Escutenaire S,Ugolini M,Pesonen SK,Bramante S,Parviainen S,Kanerva A,Loskog AS,Eliopoulos AG,Pesonen S,Hemminki A
14-0041 was used in Immunohistochemistry to test whether a transcriptionally targeted oncolytic adenovirus, which features a capsid modification and is armed with CD40L, can result in oncolytic antitumor activity and stimulate an immune response.
Tue May 01 00:00:00 EDT 2012
PIDDosome-independent tumor suppression by Caspase-2.
Cell death and differentiation
Manzl C,Peintner L,Krumschnabel G,Bock F,Labi V,Drach M,Newbold A,Johnstone R,Villunger A
14-0041 was used in Flow cytometry/Cell sorting to investigate the role of PIDD, RIP-1 kinase and Nemo/IKKγ in oncogenesis induced by DNA damage or oncogenic stress in gene-ablated mice.
Mon Oct 01 00:00:00 EDT 2012
Immunity to sand fly salivary protein LJM11 modulates host response to vector-transmitted leishmania conferring ulcer-free protection.
The Journal of investigative dermatology
Gomes R,Oliveira F,Teixeira C,Meneses C,Gilmore DC,Elnaiem DE,Kamhawi S,Valenzuela JG
14-0041 was used in Flow cytometry/Cell sorting to investigate LJM11 as an immunomodulator that drives an efficient and controlled protective immune response to a sand fly-transmitted Leishmania.
Sat Dec 01 00:00:00 EST 2012
FOXO3 regulates CD8 T cell memory by T cell-intrinsic mechanisms.
PLoS pathogens
Sullivan JA,Kim EH,Plisch EH,Peng SL,Suresh M
14-0041-82 was used in Immunodepletion to elucidate the potentially dynamic role for FOXO3 in regulating homeostasis of activated CD8 T cells in lymphoid and non-lymphoid organs.
Wed Feb 01 00:00:00 EST 2012
Age-related dysfunction of the lacrimal gland and oxidative stress: evidence from the Cu,Zn-superoxide dismutase-1 (Sod1) knockout mice.
The American journal of pathology
Kojima T,Wakamatsu TH,Dogru M,Ogawa Y,Igarashi A,Ibrahim OM,Inaba T,Shimizu T,Noda S,Obata H,Nakamura S,Wakamatsu A,Shirasawa T,Shimazaki J,Negishi K,Tsubota K
14-0041 was used in Immunofluorescence to investigate how Sod1(-/-) mice may be a good model system in which to study the mechanism of reactive oxygen species-mediated lacrimal gland alterations.
Tue May 01 00:00:00 EDT 2012
NK cells are required for costimulatory blockade induced tolerance to vascularized allografts.
Transplantation
van der Touw W,Burrell B,Lal G,Bromberg JS
14-0041 was used in Immunohistochemistry on frozen tissues to investigate the role of NK cells in allograft tolerance, showing that they are required for costimulatory blockade induced tolerance to vascularised allografts.
Thu Sep 27 00:00:00 EDT 2012
Role of Francisella lipid A phosphate modification in virulence and long-term protective immune responses.
Infection and immunity
Kanistanon D,Powell DA,Hajjar AM,Pelletier MR,Cohen IE,Way SS,Skerrett SJ,Wang X,Raetz CR,Ernst RK
14-0041 was used in Flow cytometry/Cell sorting to study the pathogenic effects of LPS modifications at the lipid A component of a Francisella novicida mutant.
Thu Mar 01 00:00:00 EST 2012
Depletion of neutrophils in a protective model of pulmonary cryptococcosis results in increased IL-17A production by γδ T cells.
BMC immunology
Wozniak KL,Kolls JK,Wormley FL
14-0041 was used in Immunodepletion to study the role of γδ+ T cells in mediating IL-17A production in neutropenic mice during the protective response to Cryptococcus neoformans infection.
Fri Dec 07 00:00:00 EST 2012
Recombinant lipidated HPV E7 induces a Th-1-biased immune response and protective immunity against cervical cancer in a mouse model.
PloS one
Huang CY,Chen JJ,Shen KY,Chang LS,Yeh YC,Chen IH,Chong P,Liu SJ,Leng CH
14-0041 was used in Functional assays to demonstrate that rlipo-E7m could be a promising candidate for treating HPV-associated tumors.
Wed Jan 16 00:00:00 EST 2013
CD69 does not affect the extent of T cell priming.
PloS one
Alari-Pahissa E,Notario L,Lorente E,Vega-Ramos J,Justel A,López D,Villadangos JA,Lauzurica P
14-0041 was used in Flow cytometry/Cell sorting to investigate the role of CD69 in T cell activation, showing that CD69 does not affect the extent of T cell priming.
Mon May 06 00:00:00 EDT 2013
Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.
PloS one
Gong Y,Wang Z,Liang Z,Duan H,Ouyang L,Yu Q,Xu Z,Shen G,Weng X,Wu X
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Fri Jul 19 00:00:00 EDT 2013
CD4 T-cell-independent antibody response reduces enterovirus 71 lethality in mice by decreasing tissue viral loads.
Clinical & developmental immunology
Wang LC,Kao CM,Ling P,Su IJ,Chang TM,Chen SH
14-0041 was used in Flow cytometry/Cell sorting to show that the CD4 T-cell-independent antibody response promotes the survival of EV71-infected mice.
Thu May 16 00:00:00 EDT 2013
Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice.
The Journal of clinical investigation
Woller N,Knocke S,Mundt B,Gürlevik E,Strüver N,Kloos A,Boozari B,Schache P,Manns MP,Malek NP,Sparwasser T,Zender L,Wirth TC,Kubicka S,Kühnel F
14-0041 was used in Functional assays to highlight viruses as attractive tools for eliciting effective antitumour responses upon DC vaccination.
Fri Jul 01 00:00:00 EDT 2011
VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.
The Journal of experimental medicine
Wang L,Rubinstein R,Lines JL,Wasiuk A,Ahonen C,Guo Y,Lu LF,Gondek D,Wang Y,Fava RA,Fiser A,Almo S,Noelle RJ
14-0041 was used in Functional assays to show that VISTA has functional activities that are nonredundant with other Ig superfamily members and may play a role in the development of autoimmunity.
Mon Mar 14 00:00:00 EDT 2011
Maximal T cell-mediated antitumor responses rely upon CCR5 expression in both CD4(+) and CD8(+) T cells.
Cancer research
González-Martín A,Gómez L,Lustgarten J,Mira E,Mañes S
14-0041 was used in Immunofluorescence to investigate the relevance of the chemokine receptor CCR5 in tumoural immune control.
Mon Aug 15 00:00:00 EDT 2011
T cell-mediated protection against lethal 2009 pandemic H1N1 influenza virus infection in a mouse model.
Journal of virology
Guo H,Santiago F,Lambert K,Takimoto T,Topham DJ
14-0041 was used in Functional assays to explore the protection mechanisms of cross-reactive T-cell responses against H1N1 in vivo.
Sat Jan 01 00:00:00 EST 2011
Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle.
Molecular medicine (Cambridge, Mass.)
Eghtesad S,Jhunjhunwala S,Little SR,Clemens PR
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry
Sun Mar 25 00:00:00 EDT 2012
T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950)
Wang R,Xie H,Huang Z,Ma J,Fang X,Ding Y,Sun Z
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2011
Identification of semaphorin 4B as a negative regulator of basophil-mediated immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Nakagawa Y,Takamatsu H,Okuno T,Kang S,Nojima S,Kimura T,Kataoka TR,Ikawa M,Toyofuku T,Katayama I,Kumanogoh A
14-0041 was used in Flow cytometry/Cell sorting to screen semaphorins for immune involvement, identifying Sema4B as a suppressor of basophil-mediated Th2-skewing.
Tue Mar 01 00:00:00 EST 2011
T cell-intrinsic factors contribute to the differential ability of CD8+ T cells to rapidly secrete IFN-γ in the absence of antigen.
Journal of immunology (Baltimore, Md. : 1950)
Bou Ghanem EN,Nelson CC,D'Orazio SE
14-0041 was used in Flow cytometry/Cell sorting to demonstrate that the microenvironment in L. monocytogenes-infected BALB/c mice is sufficient to induce responsive CD8(+) T cells to rapidly secrete IFN-γ.
Tue Feb 01 00:00:00 EST 2011
Protective immunity against experimental pulmonary cryptococcosis in T cell-depleted mice.
Clinical and vaccine immunology : CVI
Wozniak KL,Young ML,Wormley FL
14-0041 was used in Functional assays to determine whether protection against experimental pulmonary cryptococcosis can be generated in T cell-deficient hosts.
Sun May 01 00:00:00 EDT 2011
Localized delivery of interferon-β by Lactobacillus exacerbates experimental colitis.
PloS one
McFarland AP,Savan R,Wagage S,Addison A,Ramakrishnan K,Karwan M,Duong T,Young HA
14-0041 was used in Flow cytometry/Cell sorting to identify a correlation between the loss/down-regulation of IFNAR1 on DCs and exacerbation of colitis.
Fri Feb 18 00:00:00 EST 2011
Expression of miRNAs miR-133b and miR-206 in the Il17a/f locus is co-regulated with IL-17 production in αβ and γδ T cells.
PloS one
Haas JD,Nistala K,Petermann F,Saran N,Chennupati V,Schmitz S,Korn T,Wedderburn LR,Förster R,Krueger A,Prinz I
14-0041 was used in Flow cytometry/Cell sorting to investigate epigenetic modifications of the Il17a/f locus, showing that expression of miRNAs miR-133b and miR-206 is co-regulated with IL-17 production in αβ and γδ T cells.
Thu Sep 29 00:00:00 EDT 2011
Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad.
Blood
Frenzel A,Labi V,Chmelewskij W,Ploner C,Geley S,Fiegl H,Tzankov A,Villunger A
14-0041 was used in Flow cytometry/Cell sorting to demonstrate the potential of BH3-only proapoptotic Bcl-2 family members to regulate excessive lymphocyte proliferation.
Thu Feb 04 00:00:00 EST 2010
Angiotensin II sustains brain inflammation in mice via TGF-beta.
The Journal of clinical investigation
Lanz TV,Ding Z,Ho PP,Luo J,Agrawal AN,Srinagesh H,Axtell R,Zhang H,Platten M,Wyss-Coray T,Steinman L
14-0041 was used in Flow cytometry/Cell sorting to identify angiotensin II as a paracrine mediator, sustaining inflammation in the CNS via TGF-β.
Sun Aug 01 00:00:00 EDT 2010
In situ vaccination combined with androgen ablation and regulatory T-cell depletion reduces castration-resistant tumor burden in prostate-specific pten knockout mice.
Cancer research
Akins EJ,Moore ML,Tang S,Willingham MC,Tooze JA,Dubey P
14-0041 was used in Immunofluorescence on frozen tissues to assess the acute and chronic effect of androgen ablation on the localisation of T-cell subsets within castration-resistant murine prostate cancer.
Sat May 01 00:00:00 EDT 2010
Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia-reperfusion injury.
The Journal of thoracic and cardiovascular surgery
Sharma AK,Laubach VE,Ramos SI,Zhao Y,Stukenborg G,Linden J,Kron IL,Yang Z
14-0041 was used in Immunohistochemistry to investigate how CD4+ T cells play a key role in mediating lung inflammation after ischemia-reperfusion.
Mon Feb 01 00:00:00 EST 2010
Store-operated Ca2+ entry through ORAI1 is critical for T cell-mediated autoimmunity and allograft rejection.
Journal of immunology (Baltimore, Md. : 1950)
McCarl CA,Khalil S,Ma J,Oh-hora M,Yamashita M,Roether J,Kawasaki T,Jairaman A,Sasaki Y,Prakriya M,Feske S
14-0041 was used in Flow cytometry/Cell sorting to reaffirm the critical role of ORAI1 for T cell function, and provide important insights into the in vivo functions of CRAC channels for T cell-mediated immunity.
Mon Nov 15 00:00:00 EST 2010
T-bet and eomesodermin are required for T cell-mediated antitumor immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Zhu Y,Ju S,Chen E,Dai S,Li C,Morel P,Liu L,Zhang X,Lu B
14-0041 was used in Flow cytometry/Cell sorting to define T-bet and Eomes as critical regulators of T cell-mediated immune responses against tumours.
Wed Sep 15 00:00:00 EDT 2010
Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity.
Gene therapy
Eghtesad S,Zheng H,Nakai H,Epperly MW,Clemens PR
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Immunohistochemistry
Wed Sep 01 00:00:00 EDT 2010
Cryptococcus neoformans variants generated by phenotypic switching differ in virulence through effects on macrophage activation.
Infection and immunity
Guerrero A,Jain N,Wang X,Fries BC
14-0041 was used in Flow cytometry/Cell sorting to investigate the interaction between macrophages and cells from smooth-colony or mucoid-colony variants arising from phenotypic switching of Cryptococcus neoformans.
Mon Mar 01 00:00:00 EST 2010
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.
Nature immunology
Koch MA,Tucker-Heard G,Perdue NR,Killebrew JR,Urdahl KB,Campbell DJ
14-0041 was used in Flow cytometry/Cell sorting to study how in a subset of CD4(+) T cells, the activities of the transcription factors Foxp3 and T-bet are overlaid.
Mon Jun 01 00:00:00 EDT 2009
Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury.
The Journal of clinical investigation
Heymann F,Meyer-Schwesinger C,Hamilton-Williams EE,Hammerich L,Panzer U,Kaden S,Quaggin SE,Floege J,Gröne HJ,Kurts C
14-0041 was used in Flow cytometry/Cell sorting to investigate the role of several immune cell types within tubulointerstitial mononuclear cell infiltrates in the progression of kidney disease.
Fri May 01 00:00:00 EDT 2009
Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice.
Diabetes
Emamaullee JA,Davis J,Merani S,Toso C,Elliott JF,Thiesen A,Shapiro AM
14-0041 was used in Immunofluorescence to suggest that Th17 cells are involved in the pathogenesis of autoimmune diabetes.
Mon Jun 01 00:00:00 EDT 2009
Critical roles of lysosomal acid lipase in T cell development and function.
The American journal of pathology
Qu P,Du H,Wilkes DS,Yan C
14-0041-82 was used in Flow Cytometry to conclude that the altered development and function of lal(-/-) T cells contributes to disease formation in various organs during LAL deficiency.
Sun Mar 01 00:00:00 EST 2009
Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis.
The American journal of pathology
Saegusa J,Hsu DK,Chen HY,Yu L,Fermin A,Fung MA,Liu FT
14-0041 was used in Immunohistochemistry on frozen tissues to investigate the role of galectin-3 in the development of allergic skin inflammation.
Sun Mar 01 00:00:00 EST 2009
Peripheral dendritic cells are essential for both the innate and adaptive antiviral immune responses in the central nervous system.
Virology
Steel CD,Hahto SM,Ciavarra RP
14-0041-82 was used in Flow Cytometry to study the adaptive primary antiviral immune response in the CNS and the effect of dendritic cells upon this in vivo.
Sat Apr 25 00:00:00 EDT 2009
Gene expression profiling of leukemia stem cells.
Methods in molecular biology (Clifton, N.J.)
Krivtsov AV,Wang Y,Feng Z,Armstrong SA
14-0041 was used in Flow cytometry/Cell sorting to illustrate methods to isolate a leukemia stem cell population, amplify RNA, and perform microarray analyses.
Tue May 19 00:00:00 EDT 2009
Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines.
Blood
Ahonen CL,Wasiuk A,Fuse S,Turk MJ,Ernstoff MS,Suriawinata AA,Gorham JD,Kedl RM,Usherwood EJ,Noelle RJ
14-0041 was used in Flow cytometry/Cell sorting to report the therapeutic effects of combinatorial use of CD40 and TLR agonists as a cancer vaccine.
Sat Mar 15 00:00:00 EDT 2008
Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus.
The Journal of experimental medicine
Iijima N,Linehan MM,Zamora M,Butkus D,Dunn R,Kehry MR,Laufer TM,Iwasaki A
14-0041 was used in Functional assays to investigate the antiviral mechanism of Th1, showing that dendritic cells and B cells maximise mucosal Th1 memory response to herpes simplex virus.
Mon Dec 22 00:00:00 EST 2008
Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus.
The Journal of experimental medicine
Iijima N,Linehan MM,Zamora M,Butkus D,Dunn R,Kehry MR,Laufer TM,Iwasaki A
14-0041 was used in Functional assays to investigate the antiviral mechanism of Th1, showing that dendritic cells and B cells maximise mucosal Th1 memory response to herpes simplex virus.
Mon Dec 22 00:00:00 EST 2008
Fundamental differences in the dynamics of CNS lesion development and composition in MP4- and MOG peptide 35-55-induced experimental autoimmune encephalomyelitis.
Clinical immunology (Orlando, Fla.)
Kuerten S,Javeri S,Tary-Lehmann M,Lehmann PV,Angelov DN
14-0041 was used in Immunohistochemistry to investigate the histopathological differences between two mouse models of experimental autoimmune encephalomyelitis.
Sat Nov 01 00:00:00 EDT 2008
IL-10 from CD4CD25Foxp3CD127 adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection.
PLoS pathogens
Couper KN,Blount DG,Wilson MS,Hafalla JC,Belkaid Y,Kamanaka M,Flavell RA,de Souza JB,Riley EM
14-0041 was used in Flow cytometry/Cell sorting to investigate the cellular source of IL-10 and TGF-beta during malaria infection, showing that IL-10 from CD4+CD25-Foxp3-CD127- adaptive Tregs modulates parasite clearance and pathology.
Fri Feb 29 00:00:00 EST 2008
Unique receptor repertoire in mouse uterine NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Yadi H,Burke S,Madeja Z,Hemberger M,Moffett A,Colucci F
14-0041-82 was used in Flow Cytometry to define the receptor repertoire and phenotype of uterine NK cells at mid-gestation in mice.
Sat Nov 01 00:00:00 EDT 2008
Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.
Investigative ophthalmology & visual science
Mochimaru H,Usui T,Yaguchi T,Nagahama Y,Hasegawa G,Usui Y,Shimmura S,Tsubota K,Amano S,Kawakami Y,Ishida S
Thu May 01 00:00:00 EDT 2008
Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulation.
The Journal of biological chemistry
Kathrein KL,Chari S,Winandy S
14-0041 was used in Flow cytometry/Cell sorting to investigate the role of the transcriptional regulator Ikaros in the regulation of the transcriptional repressor of Hes1.
Fri Apr 18 00:00:00 EDT 2008
Neutralization of IL-4 and IFN-γ Facilitates inducing TGF-β-induced CD4(+)Foxp3(+) Regulatory Cells.
International journal of biomedical science : IJBS
Tao X,Ma J,Zhang Y,Yu J,Cai L,Wang J,Zheng SG
14-0041 was used in Magnetic cell separation to determine cytokine factors that can affect the ability of TGF-β to induce Foxp3 expression.
Sat Mar 01 00:00:00 EST 2008
RhoH is important for positive thymocyte selection and T-cell receptor signaling.
Blood
Dorn T,Kuhn U,Bungartz G,Stiller S,Bauer M,Ellwart J,Peters T,Scharffetter-Kochanek K,Semmrich M,Laschinger M,Holzmann B,Klinkert WE,Straten PT,Køllgaard T,Sixt M,Brakebusch C
14-0041 was used in Flow cytometry/Cell sorting to investigate how RhoH is important for pre-TCR and TCR signaling because it allows the efficient interaction of ZAP70 with the LAT signalosome, thus regulating thymocyte development.
Thu Mar 15 00:00:00 EDT 2007
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla.
The Journal of experimental medicine
Rossi SW,Kim MY,Leibbrandt A,Parnell SM,Jenkinson WE,Glanville SH,McConnell FM,Scott HS,Penninger JM,Jenkinson EJ,Lane PJ,Anderson G
14-0041 was used in Immunofluorescence to demonstrate a novel role for a CD4(+)3(-) inducer cell population, showing that RANK signals regulate development of Aire-expressing epithelial cells in the thymic medulla.
Mon Jun 11 00:00:00 EDT 2007
Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.
Circulation
Yang Z,Day YJ,Toufektsian MC,Xu Y,Ramos SI,Marshall MA,French BA,Linden J
Tue Nov 07 00:00:00 EST 2006
Novel animal models for Sjögren's syndrome: expression and transfer of salivary gland dysfunction from regulatory T cell-deficient mice.
Journal of autoimmunity
Sharma R,Zheng L,Guo X,Fu SM,Ju ST,Jarjour WN
14-0041 was used in Flow cytometry/Cell sorting to investigate whether salivary and lacrimal glands are targeted in IL-2 knockout, IL-2Ralpha KO and scurfy mice.
Fri Dec 01 00:00:00 EST 2006
Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis.
Proceedings of the National Academy of Sciences of the United States of America
Woolf E,Xiao C,Fainaru O,Lotem J,Rosen D,Negreanu V,Bernstein Y,Goldenberg D,Brenner O,Berke G,Levanon D,Groner Y
Published figure using CD4 monoclonal antibody (Product # 14-0041-82) in Flow Cytometry
Tue Jun 24 00:00:00 EDT 2003
