Invitrogen

CD4 Monoclonal Antibody (GK1.5), Functional Grade, eBioscience™

Advanced Verification

This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.

92 Published Figures

268 References

View all (606) CD4 antibodies

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FIGURE: 1 / 95

CD4 Antibody (16-0041-82) in Flow

Staining of mouse splenocytes with Anti-Mouse CD4 PE.Appropriate isotype controls were used (open histogram).Total viable cells were used for analysis.

CD4 Antibody in Immunocytochemistry (ICC/IF)

CD4 Antibody in Immunocytochemistry, Immunohistochemistry, Immunohistochemistry (Frozen), Flow Cytometry (ICC/IF, IHC, IHC (F), Flow)

CD4 Antibody in Immunocytochemistry, Flow Cytometry (ICC/IF, Flow)

CD4 Antibody in Immunohistochemistry, Immunohistochemistry (Paraffin) (IHC, IHC (P))

CD4 Antibody in Immunohistochemistry (Frozen) (IHC (F))

CD4 Antibody in Immunohistochemistry (IHC)

CD4 Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)

Product Image Gallery

CD4 Antibody — Staining of mouse splenocytes. As expected based on known relative expression patterns, CD4 clone GK1.5 stains about 25% of total lymphocytes and does not stain CD45R (B220)+ B cells. Details: Balb/c splenocytes were surface stained with CD45R (B220, clone RA3-6B2) and Rat IgG2b Isotype Control or CD4 (clone GK1.5). Cells in the lymphocyte gate were used for analysis. {RE}

Product Details

16-0041-82

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 22 publications 22 publications

Immunohistochemistry (Paraffin) (IHC (P))

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

View 6 publications 6 publications

Flow Cytometry (Flow)

0.125 µg/test

View 220 publications 220 publications

ELISA (ELISA)

View 3 publications 3 publications

Neutralization (Neu)

Assay-Dependent

View 4 publications 4 publications

Functional Assay (Functional)

Assay-Dependent

View 10 publications 10 publications

Product Specifications

Species Reactivity

Mouse

Published species

Fish, Hamster, Human, Mouse

Host/Isotype

Rat / IgG2b, kappa

Recommended Isotype Control

Rat IgG2b kappa Isotype Control (eB149/10H5), Functional Grade, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

GK1.5

Conjugate

Functional Grade Functional Grade Functional Grade

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

no preservative

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_468861

Product Specific Information

Description: The GK1.5 monoclonal antibody reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor expressed by a majority of thymocytes, subpopulation of mature T cells and dendritic cells. CD4 binds to MHC class II on the surface of antigen presenting cells and plays an important role both in T cell development and in optimal functioning of mature T cells. In T cells, CD4 associates with protein tyrosine kinase p56lck through its cytoplasmic tail. Binding of GK1.5 is blocked by RM4-5.

Applications Reported: The GK1.5 antibody has been reported for use in flow cytometric analysis. It has also been reported in isolation and depletion of CD4+ cells, blocking of ligand binding and T cell activation via CD4.

Applications Tested: The GK1.5 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Storage and handling: Use in a sterile environment.

Filtration: 0.2 µm post-manufacturing filtered.

Purity: Greater than 90%, as determined by SDS-PAGE.

Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.

Aggregation: Less than 10%, as determined by HPLC.

Target Information

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis.

Neural regeneration research

Liu C,Guo S,Liu R,Guo M,Wang Q,Chai Z,Xiao B,Ma C

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2024

YAP/STAT3 inhibited CD8⁺ T cells activity in the breast cancer immune microenvironment by inducing M2 polarization of tumor-associated macrophages.

Cancer medicine

Wang C,Shen N,Guo Q,Tan X,He S

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

B cell extracellular vesicles contain monomeric IgM that binds antigen and enters target cells.

iScience

Gutknecht MF,Holodick NE,Rothstein TL

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Sep 15 00:00:00 EDT 2023

Subconjunctival injection of human umbilical cord mesenchymal stem cells alleviates experimental allergic conjunctivitis via regulating T cell response.

Stem cell research & therapy

Li D,Ou Q,Shen Q,Lu MM,Xu JY,Jin C,Gao F,Wang J,Zhang J,Zhang J,Li J,Lu L,Xu GT,Tian H

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Oct 02 00:00:00 EDT 2023

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge.

Biomaterials

Sun S,Li E,Zhao G,Tang J,Zuo Q,Cai L,Xu C,Sui C,Ou Y,Liu C,Li H,Ding Y,Li C,Lu D,Zhang W,Luo P,Cheng P,Gao Y,Tu C,Pitard B,Rosenecker J,Wang B,Liu Y,Zou Q,Guan S

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2023

Potential involvement of the bone marrow in experimental Graves' disease and thyroid eye disease.

Frontiers in endocrinology

Gulbins A,Horstmann M,Keitsch S,Soddemann M,Wilker B,Wilson GC,Zeidan R,Hammer GD,Daser A,Bechrakis NE,Görtz GE,Eckstein A

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Oct 10 00:00:00 EDT 2023

HSF1 promotes CD69⁺ Treg differentiation to inhibit colitis progression.

Theranostics

Yu L,Zhou B,Zhu Y,Li L,Zhong Y,Zhu L,Wang H,Chen H,Xu J,Guo T,Feng L,Wang X,Cai Z,Wang J,Jin H

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Apr 18 00:00:00 EDT 2023

Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-like Autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Hodgson R,Crockford TL,Bhandari A,Kepple JD,Back J,Cawthorne E,Abeler-Dörner L,Laing AG,Clare S,Speak A,Adams DJ,Dougan G,Hayday AC,Deobagkar-Lele M,Cornall RJ,Bull KR

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Secretory MPP3 reinforce myeloid differentiation trajectory and amplify myeloid cell production.

The Journal of experimental medicine

Kang YA,Paik H,Zhang SY,Chen JJ,Olson OC,Mitchell CA,Collins A,Swann JW,Warr MR,Fan R,Passegué E

16-0041-82 was used in Flow Cytometry to identify a novel regulatory function for a secretory MPP3 subset that controls myeloid differentiation through lineage-priming and cytokine production and acts as a self-reinforcing amplification compartment in inflammatory stress and disease conditions.

Mon Aug 07 00:00:00 EDT 2023

Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting.

Frontiers in immunology

Clubb JHA,Kudling TV,Girych M,Haybout L,Pakola S,Hamdan F,Cervera-Carrascon V,Hemmes A,Grönberg-Vähä-Koskela S,Santos JM,Quixabeira DCA,Basnet S,Heiniö C,Arias V,Jirovec E,Kaptan S,Havunen R,Sorsa S,Erikat A,Schwartz J,Anttila M,Aro K,Viitala T,Vattulainen I,Cerullo V,Kanerva A,Hemminki A

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Feb 27 00:00:00 EST 2023

GH18 family glycoside hydrolase Chitinase A of Salmonella enhances virulence by facilitating invasion and modulating host immune responses.

PLoS pathogens

Chandra K,Roy Chowdhury A,Chatterjee R,Chakravortty D

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Apr 01 00:00:00 EDT 2022

Rotenone aggravates PD-like pathology in A53T mutant human α-synuclein transgenic mice in an age-dependent manner.

Frontiers in aging neuroscience

Chen AD,Cao JX,Chen HC,Du HL,Xi XX,Sun J,Yin J,Jing YH,Gao LP

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Aug 26 00:00:00 EDT 2022

IL-33 Deficiency Attenuates Lung Inflammation by Inducing Th17 Response and Impacting the Th17/Treg Balance in LPS-Induced ARDS Mice via Dendritic Cells.

Journal of immunology research

Cheng L,Jiao Y,Jiang W,Zhang X,Zhang L,Jia G

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Dec 27 00:00:00 EST 2022

Interferon-γ Stimulates Interleukin-27 Derived from Dendritic Cells to Regulate Th9 Differentiation through STAT1/3 Pathway.

Disease markers

Xiong P,Liu T,Chen Y,Xu Q,Hu X,Han F,Shi L

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Oct 31 00:00:00 EDT 2022

CD4⁺ CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.

Aging and disease

Shen S,Li Y,Jin M,Fan D,Pan R,Lin A,Chen Y,Xiang L,Zhao RC,Shao J

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2022

Free Fatty Acid Receptor 4 (FFA4) Activation Ameliorates Imiquimod-Induced Psoriasis in Mice.

International journal of molecular sciences

Son SE,Koh JM,Im DS

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Apr 19 00:00:00 EDT 2022

Btla signaling in conventional and regulatory lymphocytes coordinately tempers humoral immunity in the intestinal mucosa.

Cell reports

Stienne C,Virgen-Slane R,Elmén L,Veny M,Huang S,Nguyen J,Chappell E,Balmert MO,Shui JW,Hurchla MA,Kronenberg M,Peterson SN,Murphy KM,Ware CF,Šedý JR

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunohistochemistry

Tue Mar 22 00:00:00 EDT 2022

Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage.

Cell death & disease

Del Rio Oliva M,Basler M

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2022

Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.

Immunity

Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury in a non-human primate model of COVID-19.

Nature nanotechnology

Li Z,Wang Z,Dinh PC,Zhu D,Popowski KD,Lutz H,Hu S,Lewis MG,Cook A,Andersen H,Greenhouse J,Pessaint L,Lobo LJ,Cheng K

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunocytochemistry

Sun Aug 01 00:00:00 EDT 2021

NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.

Nature immunology

Gu M,Zhou X,Sohn JH,Zhu L,Jie Z,Yang JY,Zheng X,Xie X,Yang J,Shi Y,Brightbill HD,Kim JB,Wang J,Cheng X,Sun SC

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase.

International journal of oral science

Zhao X,Liu J,Zhang C,Yu N,Lu Z,Zhang S,Li Y,Li Q,Liu J,Liu D,Pan Y

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.

The Journal of experimental medicine

Sasai M,Ma JS,Okamoto M,Nishino K,Nagaoka H,Takashima E,Pradipta A,Lee Y,Kosako H,Suh PG,Yamamoto M

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Jul 05 00:00:00 EDT 2021

Eliminating mesothelioma by AAV-vectored, PD1-based vaccination in the tumor microenvironment.

Molecular therapy oncolytics

Tan Z,Chiu MS,Yan CW,Man K,Chen Z

16-0041-82 was used in Flow Cytometry to evaluate the potential of recombinant adeno-associated virus (rAAV)-vectored, PD1-based vaccination in the tumor microenvironment (TME) to activate antigen-specific T cell responses in the immune-competent murine mesothelioma model.

Fri Mar 26 00:00:00 EDT 2021

High Ambient Temperature Aggravates Experimental Autoimmune Uveitis Symptoms.

Frontiers in cell and developmental biology

Pan S,Tan H,Chang R,Wang Q,Zhu Y,Chen L,Li H,Su G,Zhou C,Cao Q,Kijlstra A,Yang P

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Apr 13 00:00:00 EDT 2021

Dynamic changes in the systemic immune responses of spinal cord injury model mice.

Neural regeneration research

Gao TY,Huang FF,Xie YY,Wang WQ,Wang LD,Mu D,Cui Y,Wang B

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Generation of a Novel Oncolytic Vaccinia Virus Using the IHD-W Strain.

Human gene therapy

Shin J,Hong SO,Kim M,Lee H,Choi H,Kim J,Hong J,Kang H,Lee E,Lee S,Kong B,Kim M,Choi H,Kim S

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

CXCR3 alleviates renal ischemia‑reperfusion injury via increase of Tregs.

Molecular medicine reports

Xian W,Wu J,Li Q,Du X,Wang N,Chen D,Gao W,Cao J

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Jul 01 00:00:00 EDT 2021

Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.

Oncology letters

Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Preliminary analysis of immunoregulatory mechanism of hyperhomocysteinemia-induced brain injury in Wistar-Kyoto rats.

Experimental and therapeutic medicine

Zhang Y,Wang L,Li X,Geng J

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Estrogen receptor beta signaling in CD8⁺ T cells boosts T cell receptor activation and antitumor immunity through a phosphotyrosine switch.

Journal for immunotherapy of cancer

Yuan B,Clark CA,Wu B,Yang J,Drerup JM,Li T,Jin VX,Hu Y,Curiel TJ,Li R

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2021

TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells.

JCI insight

de Mattos Barbosa MG,Lefferts AR,Huynh D,Liu H,Zhang Y,Fu B,Barnes J,Samaniego M,Bram RJ,Geha RS,Shikanov A,Prak ETL,Farkash EA,Platt JL,Cascalho M

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunohistochemistry

Wed Sep 08 00:00:00 EDT 2021

Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy.

Frontiers in immunology

Agalave NM,Mody PH,Szabo-Pardi TA,Jeong HS,Burton MD

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Sep 20 00:00:00 EDT 2021

Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model.

Vaccines

Trofimova O,Korotkaja K,Skrastina D,Jansons J,Spunde K,Isaguliants M,Zajakina A

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Oct 27 00:00:00 EDT 2021

A lymph node-targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2.

Science advances

Steinbuck MP,Seenappa LM,Jakubowski A,McNeil LK,Haqq CM,DeMuth PC

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.

International journal of molecular sciences

Sato S,Shimizu E,He J,Ogawa M,Asai K,Yazu H,Rusch R,Yamane M,Yang F,Fukuda S,Kawakami Y,Tsubota K,Ogawa Y

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunohistochemistry

Sat Apr 03 00:00:00 EDT 2021

Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.

International journal of molecular sciences

Sato S,Shimizu E,He J,Ogawa M,Asai K,Yazu H,Rusch R,Yamane M,Yang F,Fukuda S,Kawakami Y,Tsubota K,Ogawa Y

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunohistochemistry

Sat Apr 03 00:00:00 EDT 2021

Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression.

Clinical and translational medicine

Cheng CS,Tan HY,Wang N,Chen L,Meng Z,Chen Z,Feng Y

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunohistochemistry

Tue Jun 01 00:00:00 EDT 2021

IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation.

Frontiers in immunology

Amobi-McCloud A,Muthuswamy R,Battaglia S,Yu H,Liu T,Wang J,Putluri V,Singh PK,Qian F,Huang RY,Putluri N,Tsuji T,Lugade AA,Liu S,Odunsi K

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Oct 29 00:00:00 EDT 2021

Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells.

Stem cell research & therapy

Liu W,Zhou N,Liu Y,Zhang W,Li X,Wang Y,Zheng R,Zhang Y

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Feb 26 00:00:00 EST 2021

G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence.

Cell death & disease

Sun SN,Ni SH,Li Y,Liu X,Deng JP,Chen ZX,Li H,Feng WJ,Huang YS,Li DN,Xian SX,Yang ZQ,Wang LJ,Lu L

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Jun 08 00:00:00 EDT 2021

Butyrate Improves Skin/Lung Fibrosis and Intestinal Dysbiosis in Bleomycin-Induced Mouse Models.

International journal of molecular sciences

Park HJ,Jeong OY,Chun SH,Cheon YH,Kim M,Kim S,Lee SI

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Mar 09 00:00:00 EST 2021

Mapping Rora expression in resting and activated CD4+ T cells.

PloS one

Haim-Vilmovsky L,Henriksson J,Walker JA,Miao Z,Natan E,Kar G,Clare S,Barlow JL,Charidemou E,Mamanova L,Chen X,Proserpio V,Pramanik J,Woodhouse S,Protasio AV,Efremova M,Griffin JL,Berriman M,Dougan G,Fisher J,Marioni JC,McKenzie ANJ,Teichmann SA

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Nov 12 00:00:00 EST 2021

Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid.

The Journal of biological chemistry

Zhao Y,Cheng R,Zhao Y,Ge W,Yang Y,Ding Z,Xu X,Wang Z,Wu Z,Zhang J

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Oct 01 00:00:00 EDT 2021

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.

Cancers

Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Oct 07 00:00:00 EDT 2021

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.

Cancers

Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Oct 07 00:00:00 EDT 2021

A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.

Nature communications

Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Sang W,Xie L,Wang G,Li J,Zhang Z,Li B,Guo S,Deng CX,Dai Y

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Systemic Delivery of Oncolytic Adenovirus to Tumors Using Tumor-Infiltrating Lymphocytes as Carriers.

Cells

Santos J,Heiniö C,Quixabeira D,Zafar S,Clubb J,Pakola S,Cervera-Carrascon V,Havunen R,Kanerva A,Hemminki A

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Apr 22 00:00:00 EDT 2021

Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response.

Cell reports

Vaena S,Chakraborty P,Lee HG,Janneh AH,Kassir MF,Beeson G,Hedley Z,Yalcinkaya A,Sofi MH,Li H,Husby ML,Stahelin RV,Yu XZ,Mehrotra S,Ogretmen B

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunocytochemistry

Tue May 04 00:00:00 EDT 2021

Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.

Theranostics

Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Jan 28 00:00:00 EST 2022

Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair.

Frontiers in immunology

Ramavath NN,Gadipudi LL,Provera A,Gigliotti LC,Boggio E,Bozzola C,Albano E,Dianzani U,Sutti S

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Feb 14 00:00:00 EST 2022

Remote Limb Ischemic Postconditioning Protects Against Ischemic Stroke by Promoting Regulatory T Cells Thriving.

Journal of the American Heart Association

Yu HH,Ma XT,Ma X,Chen M,Chu YH,Wu LJ,Wang W,Qin C,Tian DS

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Nov 16 00:00:00 EST 2021

Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.

Frontiers in immunology

Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Jul 05 00:00:00 EDT 2021

Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.

Immunity

Bonavita E,Bromley CP,Jonsson G,Pelly VS,Sahoo S,Walwyn-Brown K,Mensurado S,Moeini A,Flanagan E,Bell CR,Chiang SC,Chikkanna-Gowda CP,Rogers N,Silva-Santos B,Jaillon S,Mantovani A,Reis e Sousa C,Guerra N,Davis DM,Zelenay S

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Dec 15 00:00:00 EST 2020

Splenic Capture and In Vivo Intracellular Biodegradation of Biological-Grade Graphene Oxide Sheets.

ACS nano

Newman L,Jasim DA,Prestat E,Lozano N,de Lazaro I,Nam Y,Assas BM,Pennock J,Haigh SJ,Bussy C,Kostarelos K

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Aug 25 00:00:00 EDT 2020

Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.

The Journal of experimental medicine

Kang YA,Pietras EM,Passegué E

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Mar 02 00:00:00 EST 2020

Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells.

PLoS pathogens

Akhtar MN,Mishra M,Yadav V,Yadav M,Gujar R,Lal S,Kumar R,Khatri N,Sen P

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma.

Journal of cellular and molecular medicine

Song Y,Wang Z,Jiang J,Piao Y,Li L,Xu C,Piao H,Li L,Yan G

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.

Journal of cellular and molecular medicine

Wu R,Liu C,Deng X,Chen L,Hao S,Ma L

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.

Journal of Cancer

Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Effects of combined treatment with PD‑L1 Ig and CD40L mAb on immune tolerance in the CBA/J x DBA/2 mouse model.

Molecular medicine reports

Li G,Yang L,Li D,Zhang J,Du L,Xia L,Liu Y,Hu W

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma.

Cells

Martinikova AS,Burocziova M,Stoyanov M,Macurek L

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Sep 10 00:00:00 EDT 2020

FUT1 deficiency elicits immune dysregulation and corneal opacity in steady state and under stress.

Cell death & disease

Kim KW,Ryu JS,Ko JH,Kim JY,Kim HJ,Lee HJ,Oh JH,Chung JH,Oh JY

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Apr 24 00:00:00 EDT 2020

Elevated granulocytic myeloid-derived suppressor cells are closely related with elevation of Th17 cells in mice with experimental asthma.

International journal of biological sciences

Xue F,Yu M,Li L,Zhang W,Ma Y,Dong L,Shan W,Zheng Y,Wang T,Feng D,Lv J,Wang X

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Nov 12 00:00:00 EST 2021

The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function.

International journal of molecular sciences

Subbannayya Y,Haug M,Pinto SM,Mohanty V,Meås HZ,Flo TH,Prasad TSK,Kandasamy RK

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Dec 29 00:00:00 EST 2020

MicroRNA-200a induces immunosuppression by promoting PTEN-mediated PD-L1 upregulation in osteosarcoma.

Aging

Liu Z,Wen J,Wu C,Hu C,Wang J,Bao Q,Wang H,Wang J,Zhou Q,Wei L,Shen Y,Zhang W

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Jan 24 00:00:00 EST 2020

Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.

International journal of molecular sciences

Yoon CH,Ryu JS,Hwang HS,Kim MK

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Jun 11 00:00:00 EDT 2020

Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.

JCI insight

Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Aug 20 00:00:00 EDT 2020

ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.

PloS one

Hanson A,Elpek K,Duong E,Shallberg L,Fan M,Johnson C,Wallace M,Mabry GR,Sazinsky S,Pepper L,Shu CJ,Sathyanarayanan S,Zuerndorfer S,Simpson T,Gostissa M,Briskin M,Law D,Michaelson J,Harvey CJ

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Nov 16 00:00:00 EST 2020

Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.

Communications biology

Waaler J,Mygland L,Tveita A,Strand MF,Solberg NT,Olsen PA,Aizenshtadt A,Fauskanger M,Lund K,Brinch SA,Lycke M,Dybing E,Nygaard V,Bøe SL,Heintz KM,Hovig E,Hammarström C,Corthay A,Krauss S

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Apr 24 00:00:00 EDT 2020

Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.

Scientific reports

Kedzierska AE,Lorek D,Slawek A,Chelmonska-Soyta A

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Jun 29 00:00:00 EDT 2020

Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.

Frontiers in immunology

Yu Y,Wu DM,Li J,Deng SH,Liu T,Zhang T,He M,Zhao YY,Xu Y

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Jun 21 00:00:00 EDT 2021

Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.

Nature

Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Jul 01 00:00:00 EDT 2019

Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.

Cell host & microbe

Gogokhia L,Buhrke K,Bell R,Hoffman B,Brown DG,Hanke-Gogokhia C,Ajami NJ,Wong MC,Ghazaryan A,Valentine JF,Porter N,Martens E,O'Connell R,Jacob V,Scherl E,Crawford C,Stephens WZ,Casjens SR,Longman RS,Round JL

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Feb 13 00:00:00 EST 2019

TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.

Cell stem cell

Yamashita M,Passegué E

16-0041 was used in Flow cytometry/Cell sorting to reveal several TNF-α-mediated pro-survival mechanisms unique to HSCs, highlight an important role for necroptosis in HSC killing, and establish TNF-α as a major pro-survival and pro-regeneration factor for HSCs.

Thu Sep 05 00:00:00 EDT 2019

Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.

Laboratory investigation; a journal of technical methods and pathology

Hensel JA,Khattar V,Ashton R,Ponnazhagan S

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2019

Bryostatin-1 ameliorated experimental colitis in Il-10^-/- Mice by protecting the intestinal barrier and limiting immune dysfunction.

Journal of cellular and molecular medicine

Zuo L,Li J,Ge S,Ge Y,Shen M,Wang Y,Zhou C,Wu R,Hu J

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Aug 01 00:00:00 EDT 2019

Lactobacillus rhamnosus GG attenuates tenofovir disoproxil fumarate-induced bone loss in male mice via gut-microbiota-dependent anti-inflammation.

Therapeutic advances in chronic disease

Liu H,Gu R,Li W,Zhou W,Cong Z,Xue J,Liu Y,Wei Q,Zhou Y

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Sat Apr 09 00:00:00 EDT 2022

Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway.

Mediators of inflammation

Xu Y,Tang X,Yang M,Zhang S,Li S,Chen Y,Liu M,Guo Y,Lu M

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Jun 11 00:00:00 EDT 2019

IL-31 plays dual roles in lung inflammation in an OVA-induced murine asthma model.

Biology open

Huang J,Yue H,Jiang T,Gao J,Shi Y,Shi B,Wu X,Gou X

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Jan 15 00:00:00 EST 2019

Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.

Anti-cancer drugs

Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Epithelial EP4 plays an essential role in maintaining homeostasis in colon.

Scientific reports

Matsumoto Y,Nakanishi Y,Yoshioka T,Yamaga Y,Masuda T,Fukunaga Y,Sono M,Yoshikawa T,Nagao M,Araki O,Ogawa S,Goto N,Hiramatsu Y,Breyer RM,Fukuda A,Seno H

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunohistochemistry

Wed Oct 23 00:00:00 EDT 2019

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses.

NPJ vaccines

Li G,Adam A,Luo H,Shan C,Cao Z,Fontes-Garfias CR,Sarathy VV,Teleki C,Winkelmann ER,Liang Y,Sun J,Bourne N,Barrett ADT,Shi PY,Wang T

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Next Generation Sequencing for Long Non-coding RNAs Profile for CD4⁺ T Cells in the Mouse Model of Acute Asthma.

Frontiers in genetics

Wang Z,Ji N,Chen Z,Wu C,Sun Z,Yu W,Hu F,Huang M,Zhang M

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Apr 08 00:00:00 EDT 2022

Sex Differences in Mouse Popliteal Lymph Nodes.

Scientific reports

Dill-Garlow R,Chen KE,Walker AM

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Jan 30 00:00:00 EST 2019

TLR1/2 Specific Small-Molecule Agonist Suppresses Leukemia Cancer Cell Growth by Stimulating Cytotoxic T Lymphocytes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cen X,Zhu G,Yang J,Yang J,Guo J,Jin J,Nandakumar KS,Yang W,Yin H,Liu S,Cheng K

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri May 17 00:00:00 EDT 2019

Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles.

Cell reports

Cianciaruso C,Beltraminelli T,Duval F,Nassiri S,Hamelin R,Mozes A,Gallart-Ayala H,Ceada Torres G,Torchia B,Ries CH,Ivanisevic J,De Palma M

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Jun 04 00:00:00 EDT 2019

Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells.

Immunity

Halim TYF,Rana BMJ,Walker JA,Kerscher B,Knolle MD,Jolin HE,Serrao EM,Haim-Vilmovsky L,Teichmann SA,Rodewald HR,Botto M,Vyse TJ,Fallon PG,Li Z,Withers DR,McKenzie ANJ

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Jun 19 00:00:00 EDT 2018

Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling.

The Journal of clinical investigation

Emmerson A,Trevelin SC,Mongue-Din H,Becker PD,Ortiz C,Smyth LA,Peng Q,Elgueta R,Sawyer G,Ivetic A,Lechler RI,Lombardi G,Shah AM

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Jul 02 00:00:00 EDT 2018

Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.

Molecular therapy : the journal of the American Society of Gene Therapy

Ricca JM,Oseledchyk A,Walther T,Liu C,Mangarin L,Merghoub T,Wolchok JD,Zamarin D

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Apr 04 00:00:00 EDT 2018

MicroRNA-126 deficiency enhanced the activation and function of CD4⁺ T cells by elevating IRS-1 pathway.

Clinical and experimental immunology

Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells.

World journal of gastroenterology

Müller-Graff FT,Fitzner B,Jaster R,Vollmar B,Zechner D

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Sat Jul 28 00:00:00 EDT 2018

MicroRNA-126 Deficiency Affects the Development of Thymus CD4+ Single-Positive Cells through Elevating IRS-1.

International archives of allergy and immunology

Hu L,Xu H,Lu J,Zhou Y,Chu F,Zheng W,Lei L,Zhao J,Wang H,Guo M,Chen C,Xu L

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Dec 11 00:00:00 EST 2018

Human umbilical cord-derived mesenchymal stem cells ameliorate the enteropathy of food allergies in mice.

Experimental and therapeutic medicine

Yan N,Xu J,Zhao C,Wu Y,Gao F,Li C,Zhou W,Xiao T,Zhou X,Shao Q,Xia S

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Sat Dec 01 00:00:00 EST 2018

Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.

Evidence-based complementary and alternative medicine : eCAM

Pang P,Zheng K,Wu S,Xu H,Deng L,Shi Y,Chen X

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.

Nature communications

Xu Y,Ikeda S,Sumida K,Yamamoto R,Tanaka H,Minato N

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Mar 02 00:00:00 EST 2018

Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.

JCI insight

McCall CE,Zabalawi M,Liu T,Martin A,Long DL,Buechler NL,Arts RJW,Netea M,Yoza BK,Stacpoole PW,Vachharajani V

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Aug 09 00:00:00 EDT 2018

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.

eLife

Lian G,Gnanaprakasam JR,Wang T,Wu R,Chen X,Liu L,Shen Y,Yang M,Yang J,Chen Y,Vasiliou V,Cassel TA,Green DR,Liu Y,Fan TW,Wang R

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Sep 10 00:00:00 EDT 2018

A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.

Nature communications

Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Apr 18 00:00:00 EDT 2018

Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Peng J,Xiao Y,Li W,Yang Q,Tan L,Jia Y,Qu Y,Qian Z

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue May 01 00:00:00 EDT 2018

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.

eLife

Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Nov 20 00:00:00 EST 2018

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.

Journal of neuroinflammation

Unger MS,Schernthaner P,Marschallinger J,Mrowetz H,Aigner L

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Sep 21 00:00:00 EDT 2018

Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung.

Frontiers in physiology

Lim D,Kim W,Lee C,Bae H,Kim J

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Plasmodium co-infection protects against chikungunya virus-induced pathologies.

Nature communications

Teo TH,Lum FM,Ghaffar K,Chan YH,Amrun SN,Tan JJL,Lee CYP,Chua TK,Carissimo G,Lee WWL,Claser C,Rajarethinam R,Rénia L,Ng LFP

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Sep 25 00:00:00 EDT 2018

T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells.

Nature communications

Kim HR,Mun Y,Lee KS,Park YJ,Park JS,Park JH,Jeon BN,Kim CH,Jun Y,Hyun YM,Kim M,Lee SM,Park CS,Im SH,Jun CD

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Sep 07 00:00:00 EDT 2018

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects.

Journal of experimental & clinical cancer research : CR

Xu L,Zhang Y,Tian K,Chen X,Zhang R,Mu X,Wu Y,Wang D,Wang S,Liu F,Wang T,Zhang J,Liu S,Zhang Y,Tu C,Liu H

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Oct 29 00:00:00 EDT 2018

Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice.

mSphere

Quach D,Collins F,Parameswaran N,McCabe L,Britton RA

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.

Immunity, inflammation and disease

Omodho B,Miao T,Symonds ALJ,Singh R,Li S,Wang P

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Jun 01 00:00:00 EDT 2018

Store-Operated Ca²⁺ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.

Immunity

Vaeth M,Maus M,Klein-Hessling S,Freinkman E,Yang J,Eckstein M,Cameron S,Turvey SE,Serfling E,Berberich-Siebelt F,Possemato R,Feske S

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.

The Journal of clinical investigation

Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling.

The Journal of clinical investigation

Ying W,Wollam J,Ofrecio JM,Bandyopadhyay G,El Ouarrat D,Lee YS,Oh DY,Li P,Osborn O,Olefsky JM

16-0041 was used in Functional assays to demonstrate the importance of ATB2 cells in obesity-induced insulin resistance and suggest that inhibition of the LTB4/LTB4R1 axis might be a useful approach for developing insulin-sensitising therapeutics.

Wed Mar 01 00:00:00 EST 2017

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

The Journal of experimental medicine

Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Jun 05 00:00:00 EDT 2017

Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination.

Cancer research

Jiang H,Rivera-Molina Y,Gomez-Manzano C,Clise-Dwyer K,Bover L,Vence LM,Yuan Y,Lang FF,Toniatti C,Hossain MB,Fueyo J

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Sat Jul 15 00:00:00 EDT 2017

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

Proceedings of the National Academy of Sciences of the United States of America

Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Mar 21 00:00:00 EDT 2017

Upregulation of Intestinal Barrier Function in Mice with DSS-Induced Colitis by a Defined Bacterial Consortium Is Associated with Expansion of IL-17A Producing Gamma Delta T Cells.

Frontiers in immunology

Li M,Wang B,Sun X,Tang Y,Wei X,Ge B,Tang Y,Deng Y,He C,Yuan J,Li X

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.

Acta pharmacologica Sinica

Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Cornea lymphatics drive the CD8⁺ T-cell response to herpes simplex virus-1.

Immunology and cell biology

Gurung HR,Carr MM,Carr DJ

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2017

ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.

RNA biology

Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu May 04 00:00:00 EDT 2017

Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery.

Scientific reports

Ai J,Li J,Gessler DJ,Su Q,Wei Q,Li H,Gao G

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunofluorescence

Mon Jan 09 00:00:00 EST 2017

Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated with Suppressed Inflammatory Transcriptional Networks in the Mouse Colon.

Frontiers in physiology

Yang T,Ahmari N,Schmidt JT,Redler T,Arocha R,Pacholec K,Magee KL,Malphurs W,Owen JL,Krane GA,Li E,Wang GP,Vickroy TW,Raizada MK,Martyniuk CJ,Zubcevic J

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunofluorescence

Thu Oct 01 00:00:00 EDT 2020

Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease.

Scientific reports

Ogawa Y,He H,Mukai S,Imada T,Nakamura S,Su CW,Mahabole M,Tseng SC,Tsubota K

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunohistochemistry

Mon Feb 06 00:00:00 EST 2017

Location of tumor affects local and distant immune cell type and number.

Immunity, inflammation and disease

Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury.

Stem cell research & therapy

Zhu D,Tan J,Maleken AS,Muljadi R,Chan ST,Lau SN,Elgass K,Leaw B,Mockler J,Chambers D,Leeman KT,Kim CF,Wallace EM,Lim R

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Nov 10 00:00:00 EST 2017

MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis.

Stem cell reports

Shigemoto-Kuroda T,Oh JY,Kim DK,Jeong HJ,Park SY,Lee HJ,Park JW,Kim TW,An SY,Prockop DJ,Lee RH

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue May 09 00:00:00 EDT 2017

Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mice by Selectively Altering the Gut Microbiota and Promoting Intestinal Gamma-Delta T Cells.

Frontiers in pharmacology

Li M,Gao J,Tang Y,Liu M,Wu S,Qu K,Long X,Li H,Liu M,Liu Y,Yuan J,Mao L,Liu Y,Zheng X,Wang E,Wang J,Yang Y

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies.

PloS one

Min M,Yan BX,Wang P,Landeck L,Chen JQ,Li W,Cai SQ,Zheng M,Man XY

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Jan 16 00:00:00 EST 2018

Integrating Enhancer Mechanisms to Establish a Hierarchical Blood Development Program.

Cell reports

Mehta C,Johnson KD,Gao X,Ong IM,Katsumura KR,McIver SC,Ranheim EA,Bresnick EH

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Sep 19 00:00:00 EDT 2017

Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1⁺CXCR5^-/dim B-helper T cell induction.

Scientific reports

Eri T,Kawahata K,Kanzaki T,Imamura M,Michishita K,Akahira L,Bannai E,Yoshikawa N,Kimura Y,Satoh T,Uematsu S,Tanaka H,Yamamoto K

16-0041 was used in Immunofluorescence to study the relationship between lymphopenia and murine autoimmunity, mediated by the intestinal microbiota.

Wed Apr 26 00:00:00 EDT 2017

WASH maintains NKp46⁺ ILC3 cells by promoting AHR expression.

Nature communications

Xia P,Liu J,Wang S,Ye B,Du Y,Xiong Z,Han ZG,Tong L,Fan Z

16-0041 was used in Flow cytometry/Cell sorting to study how WASH-mediated AHR expression has a critical function in the maintenance of NKp46(+) ILC3s.

Wed Jun 07 00:00:00 EDT 2017

Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation.

JCI insight

Tischner D,Grimm M,Kaur H,Staudenraus D,Carvalho J,Looso M,Günther S,Wanke F,Moos S,Siller N,Breuer J,Schwab N,Zipp F,Waisman A,Kurschus FC,Offermanns S,Wettschureck N

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Aug 03 00:00:00 EDT 2017

Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.

Oncoimmunology

Huang RY,Francois A,McGray AR,Miliotto A,Odunsi K

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Tbet and IL-36γ cooperate in therapeutic DC-mediated promotion of ectopic lymphoid organogenesis in the tumor microenvironment.

Oncoimmunology

Weinstein AM,Chen L,Brzana EA,Patil PR,Taylor JL,Fabian KL,Wallace CT,Jones SD,Watkins SC,Lu B,Stroncek DF,Denning TL,Fu YX,Cohen PA,Storkus WJ

16-0041 was used in in vivo experiments to examine the factors that mediate the formation of ectopic lymphoid organogenesis in the tumour microenvironment.

Tue Jan 12 00:00:00 EST 2021

Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.

JCI insight

Azzam KM,Madenspacher JH,Cain DW,Lai L,Gowdy KM,Rai P,Janardhan K,Clayton N,Cunningham W,Jensen H,Patel PS,Kearney JF,Taylor GA,Fessler MB

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Aug 17 00:00:00 EDT 2017

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.

Nature communications

Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Feb 13 00:00:00 EST 2017

A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation.

EBioMedicine

Ma J,Teng X,Wang X,Fan X,Wu Y,Tian M,Zhou Z,Li L

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Cell

Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Oct 06 00:00:00 EDT 2016

Foxp3 and Toll-like receptor signaling balance T_reg cell anabolic metabolism for suppression.

Nature immunology

Gerriets VA,Kishton RJ,Johnson MO,Cohen S,Siska PJ,Nichols AG,Warmoes MO,de Cubas AA,MacIver NJ,Locasale JW,Turka LA,Wells AD,Rathmell JC

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2016

Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.

Nature cell biology

Pietras EM,Mirantes-Barbeito C,Fong S,Loeffler D,Kovtonyuk LV,Zhang S,Lakshminarasimhan R,Chin CP,Techner JM,Will B,Nerlov C,Steidl U,Manz MG,Schroeder T,Passegué E

16-0041 was used in Flow cytometry/Cell sorting to identify a critical regulatory circuit that tailors HSC responses to acute needs, and is likely to underlie deregulated blood homeostasis in chronic inflammation conditions.

Wed Jun 01 00:00:00 EDT 2016

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.

Immunology

Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2016

p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.

European journal of immunology

Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Multispectral Imaging of T and B Cells in Murine Spleen and Tumor.

Journal of immunology (Baltimore, Md. : 1950)

Feng Z,Jensen SM,Messenheimer DJ,Farhad M,Neuberger M,Bifulco CB,Fox BA

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunofluorescence

Sun May 01 00:00:00 EDT 2016

Multispectral Imaging of T and B Cells in Murine Spleen and Tumor.

Journal of immunology (Baltimore, Md. : 1950)

Feng Z,Jensen SM,Messenheimer DJ,Farhad M,Neuberger M,Bifulco CB,Fox BA

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunofluorescence

Sun May 01 00:00:00 EDT 2016

Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.

Journal of immunology (Baltimore, Md. : 1950)

Menendez CM,Jinkins JK,Carr DJ

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Aug 15 00:00:00 EDT 2016

Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.

Molecular medicine reports

Gu L,Deng WS,Sun XF,Zhou H,Xu Q

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice.

Autoimmunity

Haddad CS,Bhattacharya P,Alharshawi K,Marinelarena A,Kumar P,El-Sayed O,Elshabrawy HA,Epstein AL,Prabhakar BS

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.

Biology open

Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Sun May 15 00:00:00 EDT 2016

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.

Nature communications

Brinkman CC,Iwami D,Hritzo MK,Xiong Y,Ahmad S,Simon T,Hippen KL,Blazar BR,Bromberg JS

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Jun 21 00:00:00 EDT 2016

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.

Nature communications

Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Jun 08 00:00:00 EDT 2016

NPT088 reduces both amyloid-β and tau pathologies in transgenic mice.

Alzheimer's & dementia (New York, N. Y.)

Levenson JM,Schroeter S,Carroll JC,Cullen V,Asp E,Proschitsky M,Chung CH,Gilead S,Nadeem M,Dodiya HB,Shoaga S,Mufson EJ,Tsubery H,Krishnan R,Wright J,Solomon B,Fisher R,Gannon KS

16-0041 was used in Functional assays to establish NPT088 as a novel therapeutic approach and potential drug class that targets both Aβ and tau.

Thu Sep 01 00:00:00 EDT 2016

Interleukin-10 deficiency impairs regulatory T cell-derived neuropilin-1 functions and promotes Th1 and Th17 immunity.

Scientific reports

Wang S,Gao X,Shen G,Wang W,Li J,Zhao J,Wei YQ,Edwards CK

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Apr 14 00:00:00 EDT 2016

NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.

Nature communications

Alrefai H,Muhammad K,Rudolf R,Pham DA,Klein-Hessling S,Patra AK,Avots A,Bukur V,Sahin U,Tenzer S,Goebeler M,Kerstan A,Serfling E

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed May 25 00:00:00 EDT 2016

Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice.

BMC complementary and alternative medicine

Zhang S,Liu X,Mei L,Wang H,Fang F

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Aug 31 00:00:00 EDT 2016

OASL1 deficiency promotes antiviral protection against genital herpes simplex virus type 2 infection by enhancing type I interferon production.

Scientific reports

Oh JE,Lee MS,Kim YJ,Lee HK

16-0041 was used in Flow cytometry/Cell sorting to investigate the role of 2'-5' oligoadenylate synthetase-like 1 (OASL1) during localised viral infection in mice.

Mon Jan 11 00:00:00 EST 2016

Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition.

Oncoimmunology

Kleinpeter P,Fend L,Thioudellet C,Geist M,Sfrontato N,Koerper V,Fahrner C,Schmitt D,Gantzer M,Remy-Ziller C,Brandely R,Villeval D,Rittner K,Silvestre N,Erbs P,Zitvogel L,Quéméneur E,Préville X,Marchand JB

16-0041 was used in Flow cytometry/Cell sorting to develop a method to vectorise a hamster monoclonal IgG against murine PD-1 in Western Reserve oncolytic vaccina virus.

Tue Jan 12 00:00:00 EST 2021

Flagellin is a strong vaginal adjuvant of a therapeutic vaccine for genital cancer.

Oncoimmunology

Lee SE,Hong SH,Verma V,Lee YS,Duong TN,Jeong K,Uthaman S,Sung YC,Lee JT,Park IK,Min JJ,Rhee JH

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2016

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms.

Cell reports

Choi IY,Piccio L,Childress P,Bollman B,Ghosh A,Brandhorst S,Suarez J,Michalsen A,Cross AH,Morgan TE,Wei M,Paul F,Bock M,Longo VD

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Jun 07 00:00:00 EDT 2016

TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection.

Cell reports

Schleicher U,Paduch K,Debus A,Obermeyer S,König T,Kling JC,Ribechini E,Dudziak D,Mougiakakos D,Murray PJ,Ostuni R,Körner H,Bogdan C

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue May 03 00:00:00 EDT 2016

Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions.

Open biology

Swee LK,Tan ZW,Sanecka A,Yoshida N,Patel H,Grotenbreg G,Frickel EM,Ploegh HL

16-0041 was used in Flow cytometry/Cell sorting to show that potential effector functions and basal proliferation of CD8 T cells are set by self-reactivity thresholds.

Tue Nov 01 00:00:00 EDT 2016

Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.

Scientific reports

Ochi T,Feng Y,Kitamoto S,Nagao-Kitamoto H,Kuffa P,Atarashi K,Honda K,Teitelbaum DH,Kamada N

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Jun 15 00:00:00 EDT 2016

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Nature

Huang YH,Zhu C,Kondo Y,Anderson AC,Gandhi A,Russell A,Dougan SK,Petersen BS,Melum E,Pertel T,Clayton KL,Raab M,Chen Q,Beauchemin N,Yazaki PJ,Pyzik M,Ostrowski MA,Glickman JN,Rudd CE,Ploegh HL,Franke A,Petsko GA,Kuchroo VK,Blumberg RS

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Jan 15 00:00:00 EST 2015

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.

Nature biotechnology

Kim J,Li WA,Choi Y,Lewin SA,Verbeke CS,Dranoff G,Mooney DJ

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2015

Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner.

Blood

Yi W,Hu X,Chen Z,Liu L,Tian Y,Chen H,Cong YS,Yang F,Zhang L,Rudolph KL,Zhang Z,Zhao Y,Ju Z

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Jul 30 00:00:00 EDT 2015

IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.

The Journal of experimental medicine

Pallangyo CK,Ziegler PK,Greten FR

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Dec 14 00:00:00 EST 2015

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Developmental cell

Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Sep 14 00:00:00 EDT 2015

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Developmental cell

Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Sep 14 00:00:00 EDT 2015

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Developmental cell

Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Sep 14 00:00:00 EDT 2015

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Developmental cell

Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Sep 14 00:00:00 EDT 2015

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Developmental cell

Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Sep 14 00:00:00 EDT 2015

B cell autophagy mediates TLR7-dependent autoimmunity and inflammation.

Autophagy

Weindel CG,Richey LJ,Bolland S,Mehta AJ,Kearney JF,Huber BT

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunohistochemistry

Mon Apr 18 00:00:00 EDT 2016

IFN-γ ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation.

Proceedings of the National Academy of Sciences of the United States of America

Sosa RA,Murphey C,Robinson RR,Forsthuber TG

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunofluorescence

Tue Sep 08 00:00:00 EDT 2015

Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.

Cell death and differentiation

Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

Commensal enteric bacteria lipopolysaccharide impairs host defense against disseminated Candida albicans fungal infection.

Mucosal immunology

Jiang TT,Chaturvedi V,Ertelt JM,Xin L,Clark DR,Kinder JM,Way SS

16-0041 was used in Flow cytometry/Cell sorting to study susceptibility against Candida albicans fungal infectiong following eradication of commensal enteric bacteria, showing loss of commensal bacteria enhances antifungal immunity through robust systemic expansion of Ly6G(hi)Ly6C(int) neutrophils, suggesting that enteric bacteria restrains activation of some immune components.

Wed Jul 01 00:00:00 EDT 2015

Natural Immunity to Ebola Virus in the Syrian Hamster Requires Antibody Responses.

The Journal of infectious diseases

Prescott J,Falzarano D,Feldmann H

16-0041 was used in Neutralization experiments to investigate what constitutes an appropriate immune response to infection by ebolavirus, showing that CD4(+) T cell antibody response is required for immunity to ebola virus infection in the syrian hamster.

Thu Oct 01 00:00:00 EDT 2015

Mice lacking Axl and Mer tyrosine kinase receptors are susceptible to experimental autoimmune orchitis induction.

Immunology and cell biology

Li N,Liu Z,Zhang Y,Chen Q,Liu P,Cheng CY,Lee WM,Chen Y,Han D

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2015

B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses.

Journal of immunology (Baltimore, Md. : 1950)

Pone EJ,Lam T,Lou Z,Wang R,Chen Y,Liu D,Edinger AL,Xu Z,Casali P

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2015

Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.

Journal of immunology (Baltimore, Md. : 1950)

Suryawanshi A,Manoharan I,Hong Y,Swafford D,Majumdar T,Taketo MM,Manicassamy B,Koni PA,Thangaraju M,Sun Z,Mellor AL,Munn DH,Manicassamy S

16-0041 was used in Flow cytometry/Cell sorting to study the factors in the tissue microenvironment and signalling networks critical for programming dendritic cells to control chronic inflammation and promote tolerance, showing that Th1/Th17 responses are regulated by canonical Wnt signalling in dendritic cells and suppresses autoimmune neuroinflammation.

Wed Apr 01 00:00:00 EDT 2015

Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome.

Journal of immunology (Baltimore, Md. : 1950)

Li JT,Melton AC,Su G,Hamm DE,LaFemina M,Howard J,Fang X,Bhat S,Huynh KM,O'Kane CM,Ingram RJ,Muir RR,McAuley DF,Matthay MA,Sheppard D

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2015

Histone deacetylation of memory T lymphocytes by You-Gui-Wan alleviates allergen-induced eosinophilic airway inflammation in asthma.

Chinese medicine

Zhang HP,Fu JJ,Fan T,Zhang WB,Wang ZL,Wang L,Wang G

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Jun 15 00:00:00 EDT 2015

Programmed cell death receptor ligand 1 modulates the regulatory T cells' capacity to repress shock/sepsis-induced indirect acute lung injury by recruiting phosphatase SRC homology region 2 domain-containing phosphatase 1.

Shock (Augusta, Ga.)

Tang L,Bai J,Chung CS,Lomas-Neira J,Chen Y,Huang X,Ayala A

16-0041 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which the programmed cell death receptor 1 ligand suppresses lung injury.

Thu Jan 01 00:00:00 EST 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunofluorescence

Tue Sep 15 00:00:00 EDT 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunofluorescence

Tue Sep 15 00:00:00 EDT 2015

Mannan-modified adenovirus targeting TERT and VEGFR-2: A universal tumour vaccine.

Scientific reports

Wang Y,Zhang J,Wu Y,Ding ZY,Luo XM,Liu J,Zhong WN,Deng GH,Xia XY,Deng YT,Wei YQ,Jiang Y

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Jun 18 00:00:00 EDT 2015

Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.

Cell transplantation

Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Nov 16 00:00:00 EST 2015

Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents.

Scientific reports

Guo A,He D,Xu HB,Geng CA,Zhao J

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Sep 15 00:00:00 EDT 2015

MFG-E8 Is Critical for Embryonic Stem Cell-Mediated T Cell Immunomodulation.

Stem cell reports

Tan Y,AlKhamees B,Jia D,Li L,Couture JF,Figeys D,Jinushi M,Wang L

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Nov 10 00:00:00 EST 2015

Intranasal Administration of Lentiviral miR-135a Regulates Mast Cell and Allergen-Induced Inflammation by Targeting GATA-3.

PloS one

Deng YQ,Yang YQ,Wang SB,Li F,Liu MZ,Hua QQ,Tao ZZ

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue May 31 00:00:00 EDT 2016

Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses.

Stem cell reports

Wang WB,Yen ML,Liu KJ,Hsu PJ,Lin MH,Chen PM,Sudhir PR,Chen CH,Chen CH,Sytwu HK,Yen BL

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Sep 08 00:00:00 EDT 2015

In Situ Peptide-MHC-II Tetramer Staining of Antigen-Specific CD4+ T Cells in Tissues.

PloS one

Dileepan T,Kim HO,Cleary PP,Skinner PJ

16-0041 was used in Immunohistochemistry to show 2W:I-Ab tetramer-binding CD4+ T cells in GAS-2W- but not GAS-infected mice.

Thu Apr 21 00:00:00 EDT 2016

Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells.

Nature immunology

Mahmud SA,Manlove LS,Schmitz HM,Xing Y,Wang Y,Owen DL,Schenkel JM,Boomer JS,Green JM,Yagita H,Chi H,Hogquist KA,Farrar MA

16-0041 was used in Flow cytometry/Cell sorting to study the role of TNF receptors in the thymic development of Treg cells..

Thu May 01 00:00:00 EDT 2014

12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor.

The Journal of experimental medicine

Liu M,Saeki K,Matsunobu T,Okuno T,Koga T,Sugimoto Y,Yokoyama C,Nakamizo S,Kabashima K,Narumiya S,Shimizu T,Yokomizo T

16-0041 was used in Flow cytometry/Cell sorting to demonstrate the potential use of BLT2 agonists as therapeutic agents to accelerate wound healing.

Mon Jun 02 00:00:00 EDT 2014

Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.

Autophagy

Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Jul 01 00:00:00 EDT 2014

Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity.

Proceedings of the National Academy of Sciences of the United States of America

Wang L,Le Mercier I,Putra J,Chen W,Liu J,Schenk AD,Nowak EC,Suriawinata AA,Li J,Noelle RJ

16-0041 was used in Flow cytometry/Cell sorting to study the effect of VISTA genetic deficiency on T-cell-mediated inflammation, showing that the threshold for activation was lowered and that there was increased susceptibility to autoimmunity.

Tue Oct 14 00:00:00 EDT 2014

STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment.

Cancer immunology research

Ohkuri T,Ghosh A,Kosaka A,Zhu J,Ikeura M,David M,Watkins SC,Sarkar SN,Okada H

16-0041 was used in Flow cytometry/Cell sorting to display a potential use of STING agonists for the development of effective immunotherapy.

Mon Dec 01 00:00:00 EST 2014

Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.

PLoS pathogens

Ataide MA,Andrade WA,Zamboni DS,Wang D,Souza Mdo C,Franklin BS,Elian S,Martins FS,Pereira D,Reed G,Fitzgerald KA,Golenbock DT,Gazzinelli RT

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2014

CD8+ T cell-independent tumor regression induced by Fc-OX40L and therapeutic vaccination in a mouse model of glioma.

Journal of immunology (Baltimore, Md. : 1950)

Murphy KA,Erickson JR,Johnson CS,Seiler CE,Bedi J,Hu P,Pluhar GE,Epstein AL,Ohlfest JR

16-0041 was used in Flow cytometry/Cell sorting to study how Fc-OX40L and therapeutic vaccination can induce CD8+ T cell-independent tumor regression.

Wed Jan 01 00:00:00 EST 2014

Characterization of conventional and atypical receptors for the chemokine CCL2 on mouse leukocytes.

Journal of immunology (Baltimore, Md. : 1950)

Ford LB,Cerovic V,Milling SW,Graham GJ,Hansell CA,Nibbs RJ

16-0041 was used in Flow cytometry/Cell sorting to define the expression profile, scavenging activity, and ligand specificity of CCL2 receptors on mouse leukocytes.

Tue Jul 01 00:00:00 EDT 2014

Tryptophan catabolism restricts IFN-γ-expressing neutrophils and Clostridium difficile immunopathology.

Journal of immunology (Baltimore, Md. : 1950)

El-Zaatari M,Chang YM,Zhang M,Franz M,Shreiner A,McDermott AJ,van der Sluijs KF,Lutter R,Grasberger H,Kamada N,Young VB,Huffnagle GB,Kao JY

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Jul 15 00:00:00 EDT 2014

INAM plays a critical role in IFN-γ production by NK cells interacting with polyinosinic-polycytidylic acid-stimulated accessory cells.

Journal of immunology (Baltimore, Md. : 1950)

Kasamatsu J,Azuma M,Oshiumi H,Morioka Y,Okabe M,Ebihara T,Matsumoto M,Seya T

16-0041 was used in Flow cytometry/Cell sorting to investigate the in vivo function of IFN regulatory factor 3-dependent NK-activating molecule by studying a deficient mouse model.

Sat Nov 15 00:00:00 EST 2014

Regulation of cyp26a1 on Th17 cells in mouse peri-implantation.

Journal of cellular and molecular medicine

Liu HY,Chao H,Liu ZK,Xia HF,Song Z,Yang Y,Peng JP

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Sat Mar 01 00:00:00 EST 2014

Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.

Human vaccines & immunotherapeutics

Wang S,Wu B,Xue J,Wang M,Chen R,Wang B

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Jan 05 00:00:00 EST 2015

Memory B cells form in aged mice despite impaired affinity maturation and germinal center kinetics.

Experimental gerontology

Goenka R,Scholz JL,Naradikian MS,Cancro MP

16-0041 was used in Flow cytometry/Cell sorting to study how age influences the overall germinal centre reaction during a primary immune response to a thymus-dependent antigen.

Sun Jun 01 00:00:00 EDT 2014

High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Somatostatin inhibits the production of interferon-γ by intestinal epithelial cells during intestinal ischemia-reperfusion in macaques.

Digestive diseases and sciences

Liu L,Tan Q,Hu B,Wu H,Wang C,Tang C

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunohistochemistry

Wed Oct 01 00:00:00 EDT 2014

Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects.

BMC cancer

Tian H,Shi G,Yang G,Zhang J,Li Y,Du T,Wang J,Xu F,Cheng L,Zhang X,Dai L,Chen X,Zhang S,Yang Y,Yu D,Wei Y,Deng H

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Jan 29 00:00:00 EST 2014

Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects.

BMC cancer

Tian H,Shi G,Yang G,Zhang J,Li Y,Du T,Wang J,Xu F,Cheng L,Zhang X,Dai L,Chen X,Zhang S,Yang Y,Yu D,Wei Y,Deng H

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Jan 29 00:00:00 EST 2014

Systemic sensitization with the protein allergen ovalbumin augments local sensitization in atopic dermatitis.

Journal of inflammation research

Yoo J,Manicone AM,McGuire JK,Wang Y,Parks WC

16-0041 was used in Immunofluorescence to reveal a mouse model of atopic dermatitis that reveals novel insights into the pathogenesis of this complex disease.

Thu Mar 27 00:00:00 EDT 2014

Protective immunity against lethal F. tularensis holarctica LVS provided by vaccination with selected novel CD8+ T cell epitopes.

PloS one

Rotem S,Cohen O,Bar-Haim E,Bar-On L,Ehrlich S,Shafferman A

16-0041 was used in an ELISpot assay to demonstrate a novel method for bacterial clearance involving the induction of an immune response to specific pathogenic epitopes.

Wed Sep 10 00:00:00 EDT 2014

A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking β-glucans.

PloS one

Dong B,Li D,Li R,Chen SC,Liu W,Liu W,Chen L,Chen Y,Zhang X,Tong Z,Xia Y,Xia P,Wang Y,Duan Y

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2015

Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.

Development (Cambridge, England)

Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2013

Adeno-associated virus serotype 8 (AAV8) delivery of recombinant A20 to skeletal muscle reduces pathological activation of nuclear factor (NF)-κB in muscle of mdx mice.

Molecular medicine (Cambridge, Mass.)

Charan RA,Niizawa G,Nakai H,Clemens PR

16-0041 was used in Immunohistochemistry to show that overexpression of A20, using a muscle-specific promoter delivered with an adeno-associated virus serotype 8 vector, decreases activation of the NF-κB pathway in mice skeletal muscle.

Fri Feb 08 00:00:00 EST 2013

Breakdown of immune homeostasis in the testis of mice lacking Tyro3, Axl and Mer receptor tyrosine kinases.

Immunology and cell biology

Zhang Y,Li N,Chen Q,Yan K,Liu Z,Zhang X,Liu P,Chen Y,Han D

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Mon Jul 01 00:00:00 EDT 2013

β-Arrestin-1 deficiency protects mice from experimental colitis.

The American journal of pathology

Lee T,Lee E,Irwin R,Lucas PC,McCabe LR,Parameswaran N

16-0041 was used in Flow cytometry/Cell sorting to demonstrate that altered interleukin production in β-arrestin-1-deficient mice likely leads to attenuated gut inflammation.

Mon Apr 01 00:00:00 EDT 2013

A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).

Disease models & mechanisms

Carofino BL,Ayanga B,Justice MJ

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Nov 01 00:00:00 EDT 2013

Interferon gamma causes olfactory dysfunction without concomitant neuroepithelial damage.

International forum of allergy & rhinology

Pozharskaya T,Lane AP

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunohistochemistry

Fri Nov 01 00:00:00 EDT 2013

Programmed death receptor-1/programmed death receptor ligand-1 blockade after transient lymphodepletion to treat myeloma.

Journal of immunology (Baltimore, Md. : 1950)

Kearl TJ,Jing W,Gershan JA,Johnson BD

16-0041 was used in Flow cytometry/Cell sorting to demonstrate that a blockade of the PD-1/PD-L1 pathway yields positive antitumour results.

Sat Jun 01 00:00:00 EDT 2013

Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice.

Human vaccines & immunotherapeutics

Wu B,Zou Q,Hu Y,Wang B

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2013

TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes.

Developmental biology

Bai X,Trowbridge JJ,Riley E,Lee JA,DiBiase A,Kaartinen VM,Orkin SH,Zon LI

16-0041 was used in Flow cytometry/Cell sorting to study the role of TIF1γ in murine erythropoiesis and to assess its function in other blood lineages.

Tue Jan 15 00:00:00 EST 2013

The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine.

PloS one

Radulovic K,Rossini V,Manta C,Holzmann K,Kestler HA,Niess JH

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Jan 23 00:00:00 EST 2014

The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine.

PloS one

Radulovic K,Rossini V,Manta C,Holzmann K,Kestler HA,Niess JH

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Jan 23 00:00:00 EST 2014

Gr1(int)CD11b+ myeloid-derived suppressor cells in Mycobacterium tuberculosis infection.

PloS one

Obregón-Henao A,Henao-Tamayo M,Orme IM,Ordway DJ

16-0041 was used in Flow cytometry/Cell sorting to compare the bacterial burden, lung pathology and Gr1(int)CD11b(+) myeloid-derived suppressor cell immune responses in M. tuberculosis infected mice.

Fri Jun 20 00:00:00 EDT 2014

Enhanced immune response against HIV-1 induced by a heterologous DNA prime-adenovirus boost vaccination using mannosylated polyethyleneimine as DNA vaccine adjuvant.

International journal of nanomedicine

Li M,Jiang Y,Xu C,Zhang Z,Sun X

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Wed Apr 02 00:00:00 EDT 2014

Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.

PloS one

Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Jul 31 00:00:00 EDT 2014

Postnatal muscle modification by myogenic factors modulates neuropathology and survival in an ALS mouse model.

Nature communications

Park KH,Franciosi S,Leavitt BR

16-0041 was used in Functional assays to suggest that postnatal muscle modification by myogenic and metabolic regulators influences disease progression in an ALS mouse model.

Tue Jul 08 00:00:00 EDT 2014

Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse.

PloS one

Torrado E,Fountain JJ,Robinson RT,Martino CA,Pearl JE,Rangel-Moreno J,Tighe M,Dunn R,Cooper AM

16-0041 was used in an ELISpot assay to elucidate the role of B cells for the control of mycobacterial infections.

Thu Nov 14 00:00:00 EST 2013

Differential and site specific impact of B cells in the protective immune response to Mycobacterium tuberculosis in the mouse.

PloS one

Torrado E,Fountain JJ,Robinson RT,Martino CA,Pearl JE,Rangel-Moreno J,Tighe M,Dunn R,Cooper AM

16-0041 was used in an ELISpot assay to elucidate the role of B cells for the control of mycobacterial infections.

Thu Nov 14 00:00:00 EST 2013

Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo.

PloS one

Duarte JH,Di Meglio P,Hirota K,Ahlfors H,Stockinger B

16-0041 was used in Flow cytometry/Cell sorting to study how the immuno-modulatory effect of TCDD administration for EAE is not the consequence of de novo Treg generation, but the inhibition of Th17 cell differentiation.

Tue Aug 12 00:00:00 EDT 2014

New perspective on dextran sodium sulfate colitis: antigen-specific T cell development during intestinal inflammation.

PloS one

Morgan ME,Zheng B,Koelink PJ,van de Kant HJ,Haazen LC,van Roest M,Garssen J,Folkerts G,Kraneveld AD

16-0041 was used in Flow cytometry/Cell sorting to investigate the specificity of the immune cell response to colitis.

Wed Mar 05 00:00:00 EST 2014

In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation.

PloS one

Vink PM,Smout WM,Driessen-Engels LJ,de Bruin AM,Delsing D,Krajnc-Franken MA,Jansen AJ,Rovers EF,van Puijenbroek AA,Kaptein A,Nolte MA,Garritsen A,van Eenennaam H

16-0041 was used in Flow cytometry/Cell sorting to study the function of TAK1 protein in the adult immune system.

Fri Sep 06 00:00:00 EDT 2013

Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.

The Journal of experimental medicine

Billiard F,Lobry C,Darrasse-Jèze G,Waite J,Liu X,Mouquet H,DaNave A,Tait M,Idoyaga J,Leboeuf M,Kyratsous CA,Burton J,Kalter J,Klinakis A,Zhang W,Thurston G,Merad M,Steinman RM,Murphy AJ,Yancopoulos GD,Aifantis I,Skokos D

16-0041 was used in Flow cytometry/Cell sorting to investigate how Dll4-Notch signaling affects pro-T cell fate and thymic DC development, showing that it is a novel Flt3-independent pathway for DC development and autoimmunity.

Mon May 07 00:00:00 EDT 2012

Lymphotoxin-beta receptor blockade induces inflammation and fibrosis in tolerized cardiac allografts.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Nakayama Y,Bromberg JS

16-0041 was used in Flow cytometry/Cell sorting to study the effect of LTβRIg treatment in a murine cardiac allograft model.

Sat Sep 01 00:00:00 EDT 2012

Absence of Wip1 partially rescues Atm deficiency phenotypes in mice.

Oncogene

Darlington Y,Nguyen TA,Moon SH,Herron A,Rao P,Zhu C,Lu X,Donehower LA

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Mar 01 00:00:00 EST 2012

Epithelial expression of the cytosolic retinoid chaperone cellular retinol binding protein II is essential for in vivo imprinting of local gut dendritic cells by lumenal retinoids.

The American journal of pathology

McDonald KG,Leach MR,Brooke KWM,Wang C,Wheeler LW,Hanly EK,Rowley CW,Levin MS,Wagner M,Li E,Newberry RD

16-0041 was used in Flow cytometry/Cell sorting to study dendritic cell production of all-trans retinoic acid (ATRA) in vivo.

Thu Mar 01 00:00:00 EST 2012

Intratumoral hu14.18-IL-2 (IC) induces local and systemic antitumor effects that involve both activated T and NK cells as well as enhanced IC retention.

Journal of immunology (Baltimore, Md. : 1950)

Yang RK,Kalogriopoulos NA,Rakhmilevich AL,Ranheim EA,Seo S,Kim K,Alderson KL,Gan J,Reisfeld RA,Gillies SD,Hank JA,Sondel PM

16-0041 was used in Flow cytometry/Cell sorting to study how IT-IC resulted in increased numbers of activated T and NK cells within tumours, better IC retention in the tumour, enhanced inhibition of tumour growth, and improved survival compared with i.v.-IC.

Sat Sep 01 00:00:00 EDT 2012

Th2 type inflammation promotes the gradual progression of HPV-infected cervical cells to cervical carcinoma.

Gynecologic oncology

Feng Q,Wei H,Morihara J,Stern J,Yu M,Kiviat N,Hellstrom I,Hellstrom KE

16-0041 was used in Flow cytometry/Cell sorting to study the effect of Th2 inflammation upon the tumorigenesis of cervical cancer in human papillomavirus infected women.

Thu Nov 01 00:00:00 EDT 2012

Extra-thymic physiological T lineage progenitor activity is exclusively confined to cells expressing either CD127, CD90, or high levels of CD117.

PloS one

Saran N,Pommerencke J,Witzlau K,Regelin M,Krueger A

16-0041 was used in Flow cytometry/Cell sorting to suggest that a physiological thymic microenvironment does not optimally support T cell differentiation from triple negative precursors.

Mon Jun 18 00:00:00 EDT 2012

β-defensin 2 as an adjuvant promotes anti-melanoma immune responses and inhibits the growth of implanted murine melanoma in vivo.

PloS one

Mei HF,Jin XB,Zhu JY,Zeng AH,Wu Q,Lu XM,Li XB,Shen J

16-0041 was used in Flow cytometry/Cell sorting to evaluate possible function of β-defensin 2 as a positive regulator, promoting anti-tumour NK and T cell responses in vivo.

Tue Jul 31 00:00:00 EDT 2012

TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression.

PloS one

Gao X,Zhu Y,Li G,Huang H,Zhang G,Wang F,Sun J,Yang Q,Zhang X,Lu B

16-0041 was used in Flow cytometry/Cell sorting to reveal a new role for TIM-3 as an important immune regulator in the tumour microenvironment.

Fri Jun 29 00:00:00 EDT 2012

Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.

PloS one

Gong Y,Wang Z,Liang Z,Duan H,Ouyang L,Yu Q,Xu Z,Shen G,Weng X,Wu X

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Jul 19 00:00:00 EDT 2013

Clusters versus affinity-based approaches in F. tularensis whole genome search of CTL epitopes.

PloS one

Zvi A,Rotem S,Cohen O,Shafferman A

16-0041 was used in an ELISpot assay to suggest that a cluster-based approach can be valuable in identification of novel CTL epitopes in proteomes.

Fri Sep 21 00:00:00 EDT 2012

Intranasal administration of dsRNA analog poly(I:C) induces interferon-α receptor-dependent accumulation of antigen experienced T cells in the airways.

PloS one

McNally B,Willette M,Ye F,Partida-Sanchez S,Flaño E

16-0041 was used in Flow cytometry/Cell sorting to elucidate the airway immune cell response to intranasally administered poly(I:C).

Tue Jun 11 00:00:00 EDT 2013

The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.

Nature immunology

Papadopoulou AS,Dooley J,Linterman MA,Pierson W,Ucar O,Kyewski B,Zuklys S,Hollander GA,Matthys P,Gray DH,De Strooper B,Liston A

16-0041 was used in Flow cytometry/Cell sorting to find that the microRNA network dependent on the endoribonuclease Dicer, was critical for diminishing the sensitivity of the thymic epithelium to simulated infection signals.

Sun Dec 18 00:00:00 EST 2011

Leukocyte nicotinamide adenine dinucleotide phosphate-reduced oxidase is required for isocyanate-induced lung inflammation.

The Journal of allergy and clinical immunology

Liu SY,Wang WZ,Yen CL,Tsai MY,Yang PW,Wang JY,Ho CY,Shieh CC

16-0041 was used in Neutralization experiments to reveal that leukocyte NADPH oxidase is an essential regulator of toluene diisocyanate-induced airway inflammation through redox modification of immune responses.

Fri Apr 01 00:00:00 EDT 2011

The ICOS/ICOSL pathway is required for optimal antitumor responses mediated by anti-CTLA-4 therapy.

Cancer research

Fu T,He Q,Sharma P

16-0041 was used in Flow cytometry/Cell sorting to identify mechanisms that elicit clinical benefit in the setting of anti-CTLA-4 therapy.

Mon Aug 15 00:00:00 EDT 2011

IL-33 synergizes with TCR and IL-12 signaling to promote the effector function of CD8+ T cells.

European journal of immunology

Yang Q,Li G,Zhu Y,Liu L,Chen E,Turnquist H,Zhang X,Finn OJ,Chen X,Lu B

16-0041 was used in Flow cytometry/Cell sorting to study expression of the IL-33 receptor ST2 by type 1 cytotoxic T cells.

Tue Nov 01 00:00:00 EDT 2011

Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle.

Molecular medicine (Cambridge, Mass.)

Eghtesad S,Jhunjhunwala S,Little SR,Clemens PR

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunohistochemistry

Sun Mar 25 00:00:00 EDT 2012

T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.

Journal of immunology (Baltimore, Md. : 1950)

Wang R,Xie H,Huang Z,Ma J,Fang X,Ding Y,Sun Z

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2011

Absence of β2 integrins impairs regulatory T cells and exacerbates CD4+ T cell-dependent autoimmune carditis.

Journal of immunology (Baltimore, Md. : 1950)

Haasken S,Auger JL,Binstadt BA

16-0041 was used in Neutralization experiments to investigate the contribution of CD4(+) T cells and β(2) integrins in the pathogenesis of autoimmune arthritis and endocarditis.

Thu Sep 01 00:00:00 EDT 2011

TLR1/2 activation during heterologous prime-boost vaccination (DNA-MVA) enhances CD8+ T Cell responses providing protection against Leishmania (Viannia).

PLoS neglected tropical diseases

Jayakumar A,Castilho TM,Park E,Goldsmith-Pestana K,Blackwell JM,McMahon-Pratt D

16-0041 was used in Functional assays to investigate whether the conserved vaccine candidate antigen tryparedoxin peroxidase could provide protection against infection/disease.

Wed Jun 01 00:00:00 EDT 2011

Multiple phenotypes in adult mice following inactivation of the Coxsackievirus and Adenovirus Receptor (Car) gene.

PloS one

Pazirandeh A,Sultana T,Mirza M,Rozell B,Hultenby K,Wallis K,Vennström B,Davis B,Arner A,Heuchel R,Löhr M,Philipson L,Sollerbrant K

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Fri Sep 30 00:00:00 EDT 2011

Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation.

Proceedings of the National Academy of Sciences of the United States of America

Ishikawa E,Miyake Y,Hara H,Saito T,Yamasaki S

16-0041 was used in Flow cytometry/Cell sorting to investigate the mechanism underlying this ligand-independent pre-T-cell receptor (TCR) signalling in vivo, showing that germ-line elimination of electric charge on pre-T-cell receptor impairs autonomous signaling for beta-selection and TCR repertoire formation.

Tue Nov 16 00:00:00 EST 2010

Persistent gamma-herpesvirus infection induces a CD4 T cell response containing functionally distinct effector populations.

Journal of immunology (Baltimore, Md. : 1950)

Stuller KA,Cush SS,Flaño E

16-0041 was used in Flow cytometry/Cell sorting to investigate the response of CD4 T cells to persistent γ-herpesvirus latent infection, and the mechanism by which they mediate these effects.

Thu Apr 01 00:00:00 EDT 2010

Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity.

Gene therapy

Eghtesad S,Zheng H,Nakai H,Epperly MW,Clemens PR

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunohistochemistry

Wed Sep 01 00:00:00 EDT 2010

Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity.

Gene therapy

Eghtesad S,Zheng H,Nakai H,Epperly MW,Clemens PR

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Immunohistochemistry

Wed Sep 01 00:00:00 EDT 2010

Inhibition of T cells provides protection against early invasive pneumococcal disease.

Infection and immunity

LeMessurier K,Häcker H,Tuomanen E,Redecke V

16-0041 was used in Functional assays to investigate the role of T cells during early stages of Streptococcus pneumoniae infection and invasive pneumococcal disease.

Wed Dec 01 00:00:00 EST 2010

CD4 T cells mediate mucosal and systemic immune responses to experimental hookworm infection.

Parasite immunology

Dondji B,Sun T,Bungiro RD,Vermeire JJ,Harrison LM,Bifulco C,Cappello M

16-0041 was used in Flow cytometry/Cell sorting to demonstrate an effector role for CD4+ T-cells in hookworm immunity and disease pathogenesis.

Tue Jun 01 00:00:00 EDT 2010

Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness.

American journal of respiratory and critical care medicine

Wilson RH,Whitehead GS,Nakano H,Free ME,Kolls JK,Cook DN

16-0041 was used in Flow cytometry/Cell sorting to investigate whether allergic sensitisation through the airway elicits immune responses qualitatively different than those arising in the peritoneum.

Thu Oct 15 00:00:00 EDT 2009

Migratory and antigen presentation functions of IFN-producing killer dendritic cells.

Cancer research

Himoudi N,Yan M,Bouma G,Morgenstern D,Wallace R,Seddon B,Buddle J,Eddaoudi A,Howe SJ,Cooper N,Anderson J

16-0041 was used in Flow cytometry/Cell sorting to study how BM-IKDCs are capable of cytotoxic killing of tumour targets, and also of potent antigen presentation after encountering antigen in the context of a viable target cell.

Sat Aug 15 00:00:00 EDT 2009

CD4+ T lymphocytes mediate acute pulmonary ischemia-reperfusion injury.

The Journal of thoracic and cardiovascular surgery

Yang Z,Sharma AK,Linden J,Kron IL,Laubach VE

16-0041 was used in Neutralization experiments to show that CD4(+) T cells play a critical role in stimulating chemokine production and neutrophil chemotaxis during acute pulmonary ischemia-reperfusion injury.

Sun Mar 01 00:00:00 EST 2009

Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity.

Journal of leukocyte biology

Alves BN,Leong J,Tamang DL,Elliott V,Edelnant J,Redelman D,Singer CA,Kuhn AR,Miller R,Lowe ME,Hudig D

16-0041 was used in Flow cytometry/Cell sorting to study how extracellular PLRP2 lipase is unable to increase the cytotoxicity lost through PLRP2 ablation, and the overall role of PLRP2 in CD8 T cells..

Tue Sep 01 00:00:00 EDT 2009

Reduced Fas ligand-expressing splenic CD5+ B lymphocytes in severe collagen-induced arthritis.

Arthritis research & therapy

Lundy SK,Fox DA

16-0041 was used in Flow cytometry/Cell sorting to investigate immune regulation in a mouse model of rheumatoid arthritis that exhibits considerable heterogeneity of disease activity.

Wed Dec 16 00:00:00 EST 2009

Chlamydia muridarum-specific CD4 T-cell clones recognize infected reproductive tract epithelial cells in an interferon-dependent fashion.

Infection and immunity

Jayarapu K,Kerr MS,Katschke A,Johnson RM

16-0041 was used in Flow cytometry/Cell sorting to investigate the recognition of Chlamydia-infected epithelial cells by CD4 T-cell clones.

Thu Oct 01 00:00:00 EDT 2009

Insulin-like growth factor-binding protein-2 is a target for the immunomodulation of breast cancer.

Cancer research

Park KH,Gad E,Goodell V,Dang Y,Wild T,Higgins D,Fintak P,Childs J,Dela Rosa C,Disis ML

16-0041 was used in Functional assays to highlight IGFBP-2 as a human tumor antigen that may be a functional therapeutic target in breast cancer.

Wed Oct 15 00:00:00 EDT 2008

Enumeration and functional evaluation of virus-specific CD4+ and CD8+ T cells in lymphoid and peripheral sites of coxsackievirus B3 infection.

Journal of virology

Kemball CC,Harkins S,Whitton JL

16-0041 was used in Flow cytometry/Cell sorting to evaluate CVB3 epitope-specific CD8(+) and CD4(+) T-cell responses in the spleen, heart and pancreas of mice in vivo.

Thu May 01 00:00:00 EDT 2008

An eosinophil immune response characterizes the inflammatory skin disease observed in Tie-2 transgenic mice.

Journal of leukocyte biology

Voskas D,Babichev Y,Ling LS,Alami J,Shaked Y,Kerbel RS,Ciruna B,Dumont DJ

16-0041-82 was used in Functional assay to characterise the inflammatory component in the blood and skin of tyrosine kinase with immunoglobin-like and epidermal growth factor-like domain-2 (Tie-2) transgenic mice at cellular and molecular levels.

Tue Jul 01 00:00:00 EDT 2008

Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.

Investigative ophthalmology & visual science

Mochimaru H,Usui T,Yaguchi T,Nagahama Y,Hasegawa G,Usui Y,Shimmura S,Tsubota K,Amano S,Kawakami Y,Ishida S

Thu May 01 00:00:00 EDT 2008

The role of platelets in leukocyte recruitment in chronic contact hypersensitivity induced by repeated elicitation.

The American journal of pathology

Tamagawa-Mineoka R,Katoh N,Ueda E,Takenaka H,Kita M,Kishimoto S

16-0041 was used in Immunohistochemistry to demonstrate how controlling platelet activity may be useful for the treatment of chronic allergic dermatitis.

Fri Jun 01 00:00:00 EDT 2007

Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.

Circulation

Yang Z,Day YJ,Toufektsian MC,Xu Y,Ramos SI,Marshall MA,French BA,Linden J

Tue Nov 07 00:00:00 EST 2006

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis.

Proceedings of the National Academy of Sciences of the United States of America

Woolf E,Xiao C,Fainaru O,Lotem J,Rosen D,Negreanu V,Bernstein Y,Goldenberg D,Brenner O,Berke G,Levanon D,Groner Y

Published figure using CD4 monoclonal antibody (Product # 16-0041-82) in Flow Cytometry

Tue Jun 24 00:00:00 EDT 2003

Bioinformatics

Protein Aliases: CD4; CD4 antigen p55; cd4a; fCD4; Leu-3; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4)

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Gene Aliases: Cd4; L3T4; Ly-4

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UniProt ID: (Mouse) P06332

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Entrez Gene ID: (Mouse) 12504

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Function(s)

glycoprotein binding protein binding zinc ion binding coreceptor activity enzyme binding protein kinase binding protein homodimerization activity

Process(es)

cytokine production immune system process induction by virus of host cell-cell fusion immune response cell adhesion cell surface receptor signaling pathway T cell differentiation maintenance of protein location in cell T cell activation T cell selection protein palmitoleylation positive regulation of protein kinase activity positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-negative bacterium positive regulation of calcium-mediated signaling regulation of T cell activation positive regulation of T cell activation

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CD4 Monoclonal Antibody (GK1.5), Functional Grade, eBioscience™

CD4 Antibody (16-0041-82) in Flow

Product Details

16-0041-82

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (Frozen) (IHC (F))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

ELISA (ELISA)

Neutralization (Neu)

Functional Assay (Functional)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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