Invitrogen

CD4 Monoclonal Antibody (GK1.5), eFluor™ 450, eBioscience™

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

96 Published Figures

228 References

View all (606) CD4 antibodies

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CD4 Antibody (48-0041-82) in Flow

Staining of C57Bl/6 splenocytes with Anti-Human/Mouse CD45R (B220) FITC (Product # 11-0452-82) and 0.125 µg of Rat IgG2b K Isotype Control eFluor® 450 (Product # 48-4031-82) (left) or 0.125 µg of Anti-Mouse CD4 eFluor® 450 (right). Total viable cells were used for analysis.

CD4 Antibody in Immunocytochemistry (ICC/IF)

CD4 Antibody in Immunocytochemistry, Flow Cytometry (ICC/IF, Flow)

CD4 Antibody in Immunohistochemistry (Frozen) (IHC (F))

CD4 Antibody in Immunohistochemistry (IHC)

CD4 Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)

Product Image Gallery

CD4 Antibody — Staining of mouse splenocytes. As expected based on known relative expression patterns, CD4 clone GK1.5 stains about 25% of total lymphocytes and does not stain CD45R (B220)+ B cells. Details: Balb/c splenocytes were surface stained with CD45R (B220, clone RA3-6B2) and Rat IgG2b Isotype Control or CD4 (clone GK1.5). Cells in the lymphocyte gate were used for analysis. {RE}

Product Details

48-0041-82

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

View 17 publications 17 publications

Immunohistochemistry (Frozen) (IHC (F))

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Flow Cytometry (Flow)

0.25 µg/test

View 203 publications 203 publications

Functional Assay (Functional)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Mouse

Published species

Fish, Hamster, Human, Mouse

Host/Isotype

Rat / IgG2b, kappa

Recommended Isotype Control

Rat IgG2b kappa Isotype Control (eB149/10H5), eFluor™ 450, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

GK1.5

Conjugate

eFluor™ 450 eFluor™ 450 eFluor™ 450

Excitation/Emission Max

405/445 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10718983

Product Specific Information

Description: The GK1.5 monoclonal antibody reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor expressed by a majority of thymocytes, subpopulation of mature T cells and dendritic cells. CD4 binds to MHC class II on the surface of antigen presenting cells and plays an important role both in T cell development and in optimal functioning of mature T cells. In T cells, CD4 associates with protein tyrosine kinase p56lck through its cytoplasmic tail. Binding of GK1.5 is blocked by RM4-5.

Applications Reported: This GK1.5 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This GK1.5 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

eFluor® 450 is an alternative to Pacific Blue®. eFluor® 450 emits at 445 nm and is excited with the Violet laser (405 nm). Please make sure that your instrument is capable of detecting this fluorochome.

Excitation: 405 nm; Emission: 445 nm; Laser: Violet Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis.

Neural regeneration research

Liu C,Guo S,Liu R,Guo M,Wang Q,Chai Z,Xiao B,Ma C

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2024

YAP/STAT3 inhibited CD8⁺ T cells activity in the breast cancer immune microenvironment by inducing M2 polarization of tumor-associated macrophages.

Cancer medicine

Wang C,Shen N,Guo Q,Tan X,He S

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

B cell extracellular vesicles contain monomeric IgM that binds antigen and enters target cells.

iScience

Gutknecht MF,Holodick NE,Rothstein TL

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Sep 15 00:00:00 EDT 2023

Subconjunctival injection of human umbilical cord mesenchymal stem cells alleviates experimental allergic conjunctivitis via regulating T cell response.

Stem cell research & therapy

Li D,Ou Q,Shen Q,Lu MM,Xu JY,Jin C,Gao F,Wang J,Zhang J,Zhang J,Li J,Lu L,Xu GT,Tian H

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Oct 02 00:00:00 EDT 2023

Targeting PCSK9 reduces cancer cell stemness and enhances antitumor immunity in head and neck cancer.

iScience

Yang QC,Wang S,Liu YT,Song A,Wu ZZ,Wan SC,Li HM,Sun ZJ

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Jun 16 00:00:00 EDT 2023

Targeting PCSK9 reduces cancer cell stemness and enhances antitumor immunity in head and neck cancer.

iScience

Yang QC,Wang S,Liu YT,Song A,Wu ZZ,Wan SC,Li HM,Sun ZJ

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Jun 16 00:00:00 EDT 2023

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge.

Biomaterials

Sun S,Li E,Zhao G,Tang J,Zuo Q,Cai L,Xu C,Sui C,Ou Y,Liu C,Li H,Ding Y,Li C,Lu D,Zhang W,Luo P,Cheng P,Gao Y,Tu C,Pitard B,Rosenecker J,Wang B,Liu Y,Zou Q,Guan S

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2023

6-Mercaptopurine potently inhibits recruitment of SHP2 by phosphorylated PD-1 to inhibit PD-1 signalling and enhance T cell function.

Immunology

Liu L,Lei Y,Zheng Z,Zhou X,Chen S,Zeng G,Yu L,Wang P,Chen L

48-0041-82 was used in Flow Cytometry to reveal a novel anti-tumour mechanism for the drug 6-mercaptopurine (6-MP) and suggests that 6-MP warrants further clinical evaluation for other tumour types.

Sun Oct 01 00:00:00 EDT 2023

Sex-specific differences in T-cell immune dysregulation and aberrant response to inflammatory stimuli in offspring exposed to maternal chronic inflammation.

American journal of reproductive immunology (New York, N.Y. : 1989)

Liu J,Liu Y,Kirschen G,Liu A,Lei J,Burd I

48-0041-82 was used in Flow cytometry/Cell sorting to investigate how MI affects the T-cell immune development from the fetal to the neonatal period and how offspring responded to postnatal IL-1β challenge when exposed to an adverse intrauterine environment.

Wed Mar 01 00:00:00 EST 2023

TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state.

Cell reports

Matsuda S,Revandkar A,Dubash TD,Ravi A,Wittner BS,Lin M,Morris R,Burr R,Guo H,Seeger K,Szabolcs A,Che D,Nieman L,Getz GA,Ting DT,Lawrence MS,Gainor J,Haber DA,Maheswaran S

48-0041-82 was used in Flow Cytometry to investigate whether TGF-β in the hypoxic tumor microenvironment (TME) induces senescence in cancer and how the ensuing senescence-associated secretory phenotype (SASP) remodels the cellular TME to influence immune checkpoint inhibitor (ICI) responses.

Tue Mar 28 00:00:00 EDT 2023

HSF1 promotes CD69⁺ Treg differentiation to inhibit colitis progression.

Theranostics

Yu L,Zhou B,Zhu Y,Li L,Zhong Y,Zhu L,Wang H,Chen H,Xu J,Guo T,Feng L,Wang X,Cai Z,Wang J,Jin H

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Apr 18 00:00:00 EDT 2023

Deletion of CD36 exhibits limited impact on normal hematopoiesis and the leukemia microenvironment.

Cellular & molecular biology letters

Meng Y,Pospiech M,Ali A,Chandwani R,Vergel M,Onyemaechi S,Yaghmour G,Lu R,Alachkar H

48-0041-82 was used in Flow cytometry/Cell sorting to investigate whether targeting CD36 has any detrimental impact on normal hematopoietic cells.

Wed May 24 00:00:00 EDT 2023

The eIF4EBP-eIF4E axis regulates CD4⁺ T cell differentiation through modulation of T cell activation and metabolism.

iScience

Istomine R,Al-Aubodah TA,Alvarez F,Smith JA,Wagner C,Piccirillo CA

48-0041-82 was used in Flow Cytometry to examine how altered eIF4E activity affected T cell function using mice lacking eIF4E-binding proteins (BP-/-).

Fri May 19 00:00:00 EDT 2023

Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-like Autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Hodgson R,Crockford TL,Bhandari A,Kepple JD,Back J,Cawthorne E,Abeler-Dörner L,Laing AG,Clare S,Speak A,Adams DJ,Dougan G,Hayday AC,Deobagkar-Lele M,Cornall RJ,Bull KR

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Microbially-Induced Exosomes from Dendritic Cells Promote Paracrine Immune Senescence: Novel Mechanism of Bone Degenerative Disease in Mice.

Aging and disease

Elsayed R,Elashiry M,Liu Y,Morandini AC,El-Awady A,Elashiry MM,Hamrick M,Cutler CW

48-0041-82 was used in Flow cytometry/Cell sorting to conclude that immune senescence, compounded by advanced age, and accelerated by oral dysbiosis and its induced SASP exosomes, plays a pivotal role in the pathophysiology of experimental periodontitis.

Wed Feb 01 00:00:00 EST 2023

Loss of C3a and C5a receptors promotes adipocyte browning and attenuates diet-induced obesity via activating inosine/A2aR pathway.

Cell reports

Kong LR,Chen XH,Sun Q,Zhang KY,Xu L,Ding L,Zhou YP,Zhang ZB,Lin JR,Gao PJ

48-0041-82 was used in Flow cytometry/Cell sorting to identify C3aR and C5aR as critical switches to control adipocyte browning and energy balance in male mice, via inosine/A2aR pathway.

Tue Feb 28 00:00:00 EST 2023

Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting.

Frontiers in immunology

Clubb JHA,Kudling TV,Girych M,Haybout L,Pakola S,Hamdan F,Cervera-Carrascon V,Hemmes A,Grönberg-Vähä-Koskela S,Santos JM,Quixabeira DCA,Basnet S,Heiniö C,Arias V,Jirovec E,Kaptan S,Havunen R,Sorsa S,Erikat A,Schwartz J,Anttila M,Aro K,Viitala T,Vattulainen I,Cerullo V,Kanerva A,Hemminki A

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Feb 27 00:00:00 EST 2023

GH18 family glycoside hydrolase Chitinase A of Salmonella enhances virulence by facilitating invasion and modulating host immune responses.

PLoS pathogens

Chandra K,Roy Chowdhury A,Chatterjee R,Chakravortty D

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Apr 01 00:00:00 EDT 2022

Rotenone aggravates PD-like pathology in A53T mutant human α-synuclein transgenic mice in an age-dependent manner.

Frontiers in aging neuroscience

Chen AD,Cao JX,Chen HC,Du HL,Xi XX,Sun J,Yin J,Jing YH,Gao LP

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Aug 26 00:00:00 EDT 2022

IL-33 Deficiency Attenuates Lung Inflammation by Inducing Th17 Response and Impacting the Th17/Treg Balance in LPS-Induced ARDS Mice via Dendritic Cells.

Journal of immunology research

Cheng L,Jiao Y,Jiang W,Zhang X,Zhang L,Jia G

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Dec 27 00:00:00 EST 2022

Interferon-γ Stimulates Interleukin-27 Derived from Dendritic Cells to Regulate Th9 Differentiation through STAT1/3 Pathway.

Disease markers

Xiong P,Liu T,Chen Y,Xu Q,Hu X,Han F,Shi L

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Oct 31 00:00:00 EDT 2022

CD4⁺ CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.

Aging and disease

Shen S,Li Y,Jin M,Fan D,Pan R,Lin A,Chen Y,Xiang L,Zhao RC,Shao J

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2022

Free Fatty Acid Receptor 4 (FFA4) Activation Ameliorates Imiquimod-Induced Psoriasis in Mice.

International journal of molecular sciences

Son SE,Koh JM,Im DS

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Apr 19 00:00:00 EDT 2022

Btla signaling in conventional and regulatory lymphocytes coordinately tempers humoral immunity in the intestinal mucosa.

Cell reports

Stienne C,Virgen-Slane R,Elmén L,Veny M,Huang S,Nguyen J,Chappell E,Balmert MO,Shui JW,Hurchla MA,Kronenberg M,Peterson SN,Murphy KM,Ware CF,Šedý JR

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunohistochemistry

Tue Mar 22 00:00:00 EDT 2022

Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage.

Cell death & disease

Del Rio Oliva M,Basler M

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2022

Maternal-fetal conflict averted by progesterone- induced FOXP3+ regulatory T cells.

iScience

Severance AL,Kinder JM,Xin L,Burg AR,Shao TY,Pham G,Tilburgs T,Goodman WA,Mesiano S,Way SS

48-0041-82 was used in Flow cytometry/Cell sorting to show that the female reproductive hormone, progesterone, coordinates immune tolerance by stimulating expansion of FOXP3+ regulatory T cells.

Fri Jun 17 00:00:00 EDT 2022

Enhancing and inhibitory motifs regulate CD4 activity.

eLife

Lee MS,Tuohy PJ,Kim CY,Lichauco K,Parrish HL,Van Doorslaer K,Kuhns MS

48-0041-82 was used in Flow Cytometry to indicate that CD4-Lck interactions derive their importance from the counterbalancing activity of the inhibitory motif, as well as motifs that direct CD4-Lck pairs to specific membrane compartments.

Thu Jul 21 00:00:00 EDT 2022

In vivo genome-wide CRISPR screening identifies ZNF24 as a negative NF-κB modulator in lung cancer.

Cell & bioscience

Liu L,Lei Y,Chen W,Zhou Q,Zheng Z,Zeng G,Liu W,Feng P,Zhang Z,Yu L,Chen L

48-0041-82 was used in Flow cytometry/Cell sorting to reveal an important role played by loss of function of ZNF24 in lung tumorigenesis and shed new light in precision medicine for a portion of lung cancer patients.

Thu Dec 01 00:00:00 EST 2022

MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function.

Immunity

Sugiura A,Andrejeva G,Voss K,Heintzman DR,Xu X,Madden MZ,Ye X,Beier KL,Chowdhury NU,Wolf MM,Young AC,Greenwood DL,Sewell AE,Shahi SK,Freedman SN,Cameron AM,Foerch P,Bourne T,Garcia-Canaveras JC,Karijolich J,Newcomb DC,Mangalam AK,Rabinowitz JD,Rathmell JC

48-0041-82 was used in Flow cytometry/Cell sorting to show that MTHFD2 is a metabolic checkpoint to integrate purine metabolism with pathogenic effector cell signaling and is a potential therapeutic target within 1C metabolism pathways.

Tue Jan 11 00:00:00 EST 2022

Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.

Immunity

Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.

Immunity

Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury in a non-human primate model of COVID-19.

Nature nanotechnology

Li Z,Wang Z,Dinh PC,Zhu D,Popowski KD,Lutz H,Hu S,Lewis MG,Cook A,Andersen H,Greenhouse J,Pessaint L,Lobo LJ,Cheng K

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunocytochemistry

Sun Aug 01 00:00:00 EDT 2021

NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.

Nature immunology

Gu M,Zhou X,Sohn JH,Zhu L,Jie Z,Yang JY,Zheng X,Xie X,Yang J,Shi Y,Brightbill HD,Kim JB,Wang J,Cheng X,Sun SC

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase.

International journal of oral science

Zhao X,Liu J,Zhang C,Yu N,Lu Z,Zhang S,Li Y,Li Q,Liu J,Liu D,Pan Y

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.

The Journal of experimental medicine

Sasai M,Ma JS,Okamoto M,Nishino K,Nagaoka H,Takashima E,Pradipta A,Lee Y,Kosako H,Suh PG,Yamamoto M

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Jul 05 00:00:00 EDT 2021

An immune-competent, replication-permissive Syrian Hamster glioma model for evaluating Delta-24-RGD oncolytic adenovirus.

Neuro-oncology

Phillips LM,Li S,Gumin J,Daou M,Ledbetter D,Yang J,Singh S,Parker Kerrigan BC,Hossain A,Yuan Y,Gomez-Manzano C,Fueyo J,Lang FF

48-0041-82 was used in Flow cytometry/Cell sorting to develop the first intracranial glioma model that is both adenovirus replication-permissive and immunocompetent.

Tue Nov 02 00:00:00 EDT 2021

High Ambient Temperature Aggravates Experimental Autoimmune Uveitis Symptoms.

Frontiers in cell and developmental biology

Pan S,Tan H,Chang R,Wang Q,Zhu Y,Chen L,Li H,Su G,Zhou C,Cao Q,Kijlstra A,Yang P

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Apr 13 00:00:00 EDT 2021

Dynamic changes in the systemic immune responses of spinal cord injury model mice.

Neural regeneration research

Gao TY,Huang FF,Xie YY,Wang WQ,Wang LD,Mu D,Cui Y,Wang B

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Generation of a Novel Oncolytic Vaccinia Virus Using the IHD-W Strain.

Human gene therapy

Shin J,Hong SO,Kim M,Lee H,Choi H,Kim J,Hong J,Kang H,Lee E,Lee S,Kong B,Kim M,Choi H,Kim S

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

CXCR3 alleviates renal ischemia‑reperfusion injury via increase of Tregs.

Molecular medicine reports

Xian W,Wu J,Li Q,Du X,Wang N,Chen D,Gao W,Cao J

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Jul 01 00:00:00 EDT 2021

Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.

Oncology letters

Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Vitamin D has an effect on airway inflammation and Th17/Treg balance in asthmatic mice.

The Kaohsiung journal of medical sciences

Ma JG,Wu GJ,Xiao HL,Xiao YM,Zha L

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Dec 01 00:00:00 EST 2021

Preliminary analysis of immunoregulatory mechanism of hyperhomocysteinemia-induced brain injury in Wistar-Kyoto rats.

Experimental and therapeutic medicine

Zhang Y,Wang L,Li X,Geng J

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Estrogen receptor beta signaling in CD8⁺ T cells boosts T cell receptor activation and antitumor immunity through a phosphotyrosine switch.

Journal for immunotherapy of cancer

Yuan B,Clark CA,Wu B,Yang J,Drerup JM,Li T,Jin VX,Hu Y,Curiel TJ,Li R

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2021

TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells.

JCI insight

de Mattos Barbosa MG,Lefferts AR,Huynh D,Liu H,Zhang Y,Fu B,Barnes J,Samaniego M,Bram RJ,Geha RS,Shikanov A,Prak ETL,Farkash EA,Platt JL,Cascalho M

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunohistochemistry

Wed Sep 08 00:00:00 EDT 2021

Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy.

Frontiers in immunology

Agalave NM,Mody PH,Szabo-Pardi TA,Jeong HS,Burton MD

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Sep 20 00:00:00 EDT 2021

Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model.

Vaccines

Trofimova O,Korotkaja K,Skrastina D,Jansons J,Spunde K,Isaguliants M,Zajakina A

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Oct 27 00:00:00 EDT 2021

A lymph node-targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2.

Science advances

Steinbuck MP,Seenappa LM,Jakubowski A,McNeil LK,Haqq CM,DeMuth PC

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.

International journal of molecular sciences

Sato S,Shimizu E,He J,Ogawa M,Asai K,Yazu H,Rusch R,Yamane M,Yang F,Fukuda S,Kawakami Y,Tsubota K,Ogawa Y

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunohistochemistry

Sat Apr 03 00:00:00 EDT 2021

Positive Effects of Oral Antibiotic Administration in Murine Chronic Graft-Versus-Host Disease.

International journal of molecular sciences

Sato S,Shimizu E,He J,Ogawa M,Asai K,Yazu H,Rusch R,Yamane M,Yang F,Fukuda S,Kawakami Y,Tsubota K,Ogawa Y

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunohistochemistry

Sat Apr 03 00:00:00 EDT 2021

Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression.

Clinical and translational medicine

Cheng CS,Tan HY,Wang N,Chen L,Meng Z,Chen Z,Feng Y

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunohistochemistry

Tue Jun 01 00:00:00 EDT 2021

IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation.

Frontiers in immunology

Amobi-McCloud A,Muthuswamy R,Battaglia S,Yu H,Liu T,Wang J,Putluri V,Singh PK,Qian F,Huang RY,Putluri N,Tsuji T,Lugade AA,Liu S,Odunsi K

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Oct 29 00:00:00 EDT 2021

Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells.

Stem cell research & therapy

Liu W,Zhou N,Liu Y,Zhang W,Li X,Wang Y,Zheng R,Zhang Y

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Feb 26 00:00:00 EST 2021

G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence.

Cell death & disease

Sun SN,Ni SH,Li Y,Liu X,Deng JP,Chen ZX,Li H,Feng WJ,Huang YS,Li DN,Xian SX,Yang ZQ,Wang LJ,Lu L

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Jun 08 00:00:00 EDT 2021

Butyrate Improves Skin/Lung Fibrosis and Intestinal Dysbiosis in Bleomycin-Induced Mouse Models.

International journal of molecular sciences

Park HJ,Jeong OY,Chun SH,Cheon YH,Kim M,Kim S,Lee SI

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Mar 09 00:00:00 EST 2021

Mapping Rora expression in resting and activated CD4+ T cells.

PloS one

Haim-Vilmovsky L,Henriksson J,Walker JA,Miao Z,Natan E,Kar G,Clare S,Barlow JL,Charidemou E,Mamanova L,Chen X,Proserpio V,Pramanik J,Woodhouse S,Protasio AV,Efremova M,Griffin JL,Berriman M,Dougan G,Fisher J,Marioni JC,McKenzie ANJ,Teichmann SA

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Nov 12 00:00:00 EST 2021

Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid.

The Journal of biological chemistry

Zhao Y,Cheng R,Zhao Y,Ge W,Yang Y,Ding Z,Xu X,Wang Z,Wu Z,Zhang J

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Oct 01 00:00:00 EDT 2021

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.

Cancers

Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Oct 07 00:00:00 EDT 2021

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.

Cancers

Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Oct 07 00:00:00 EDT 2021

A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.

Nature communications

Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Sang W,Xie L,Wang G,Li J,Zhang Z,Li B,Guo S,Deng CX,Dai Y

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Systemic Delivery of Oncolytic Adenovirus to Tumors Using Tumor-Infiltrating Lymphocytes as Carriers.

Cells

Santos J,Heiniö C,Quixabeira D,Zafar S,Clubb J,Pakola S,Cervera-Carrascon V,Havunen R,Kanerva A,Hemminki A

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Apr 22 00:00:00 EDT 2021

Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response.

Cell reports

Vaena S,Chakraborty P,Lee HG,Janneh AH,Kassir MF,Beeson G,Hedley Z,Yalcinkaya A,Sofi MH,Li H,Husby ML,Stahelin RV,Yu XZ,Mehrotra S,Ogretmen B

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunocytochemistry

Tue May 04 00:00:00 EDT 2021

Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.

Theranostics

Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Jan 28 00:00:00 EST 2022

Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair.

Frontiers in immunology

Ramavath NN,Gadipudi LL,Provera A,Gigliotti LC,Boggio E,Bozzola C,Albano E,Dianzani U,Sutti S

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Feb 14 00:00:00 EST 2022

Remote Limb Ischemic Postconditioning Protects Against Ischemic Stroke by Promoting Regulatory T Cells Thriving.

Journal of the American Heart Association

Yu HH,Ma XT,Ma X,Chen M,Chu YH,Wu LJ,Wang W,Qin C,Tian DS

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Nov 16 00:00:00 EST 2021

Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.

Frontiers in immunology

Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Jul 05 00:00:00 EDT 2021

The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo.

Cell reports

Gerber AN,Abdi K,Singh NJ

48-0041-82 was used in Flow cytometry/Cell sorting to suggest that early secretion of IL-12p40 monomers by sentinel cells at the infection site may help prepare distal host tissues for potential pathogen arrival.

Tue Oct 12 00:00:00 EDT 2021

Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.

Immunity

Bonavita E,Bromley CP,Jonsson G,Pelly VS,Sahoo S,Walwyn-Brown K,Mensurado S,Moeini A,Flanagan E,Bell CR,Chiang SC,Chikkanna-Gowda CP,Rogers N,Silva-Santos B,Jaillon S,Mantovani A,Reis e Sousa C,Guerra N,Davis DM,Zelenay S

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Dec 15 00:00:00 EST 2020

Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.

Immunity

DiToro D,Harbour SN,Bando JK,Benavides G,Witte S,Laufer VA,Moseley C,Singer JR,Frey B,Turner H,Bruning J,Darley-Usmar V,Gao M,Conover C,Hatton RD,Frank S,Colonna M,Weaver CT

48-0041 was used in Flow cytometry/Cell sorting to show that, among effector T cell subsets, Th17 and Treg cells selectively expressed multiple components of the IGF system.

Tue Apr 14 00:00:00 EDT 2020

An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.

Immunity

Chopp LB,Gopalan V,Ciucci T,Ruchinskas A,Rae Z,Lagarde M,Gao Y,Li C,Bosticardo M,Pala F,Livak F,Kelly MC,Hannenhalli S,Bosselut R

48-0041-82 was used in Flow Cytometry to identify mouse and human αβ thymocyte developmental trajectories.

Tue Dec 15 00:00:00 EST 2020

An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.

Immunity

Chopp LB,Gopalan V,Ciucci T,Ruchinskas A,Rae Z,Lagarde M,Gao Y,Li C,Bosticardo M,Pala F,Livak F,Kelly MC,Hannenhalli S,Bosselut R

48-0041-82 was used in Flow Cytometry to identify mouse and human αβ thymocyte developmental trajectories.

Tue Dec 15 00:00:00 EST 2020

Dynamic regulation of chromatin organizer SATB1 via TCR-induced alternative promoter switch during T-cell development.

Nucleic acids research

Patta I,Madhok A,Khare S,Gottimukkala KP,Verma A,Giri S,Dandewad V,Seshadri V,Lal G,Misra-Sen J,Galande S

48-0041 was used in Flow cytometry/Cell sorting to study the mechanism regulating expression of SATB1 during T-cell development.

Fri Jun 19 00:00:00 EDT 2020

Splenic Capture and In Vivo Intracellular Biodegradation of Biological-Grade Graphene Oxide Sheets.

ACS nano

Newman L,Jasim DA,Prestat E,Lozano N,de Lazaro I,Nam Y,Assas BM,Pennock J,Haigh SJ,Bussy C,Kostarelos K

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Aug 25 00:00:00 EDT 2020

Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.

The Journal of experimental medicine

Kang YA,Pietras EM,Passegué E

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Mar 02 00:00:00 EST 2020

Excessive Costimulation Leads to Dysfunction of Adoptively Transferred T Cells.

Cancer immunology research

Wijewarnasuriya D,Bebernitz C,Lopez AV,Rafiq S,Brentjens RJ

48-0041 was used in Flow cytometry/Cell sorting to show excessive CD28 and 4-1BB co-stimulation can drive chimeric antigen receptor T-cell dysfunction.

Mon Jun 01 00:00:00 EDT 2020

Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells.

PLoS pathogens

Akhtar MN,Mishra M,Yadav V,Yadav M,Gujar R,Lal S,Kumar R,Khatri N,Sen P

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

IFN-Stimulated Gene 15 Is an Alarmin that Boosts the CTL Response via an Innate, NK Cell-Dependent Route.

Journal of immunology (Baltimore, Md. : 1950)

Iglesias-Guimarais V,Ahrends T,de Vries E,Knobeloch KP,Volkov A,Borst J

48-0041 was used in Flow cytometry/Cell sorting to conclude that free ISG15 is part of a newly recognized innate route to promote the CTL response.

Wed Apr 15 00:00:00 EDT 2020

IL-13 Ameliorates Neuroinflammation and Promotes Functional Recovery after Traumatic Brain Injury.

Journal of immunology (Baltimore, Md. : 1950)

Miao W,Zhao Y,Huang Y,Chen D,Luo C,Su W,Gao Y

48-0041 was used in Flow cytometry/Cell sorting to demonstrate that IL-13 treatment improved neurologic outcomes after Traumatic Brain Injury through adjusting microglia/macrophage phenotypes and inhibiting inflammatory responses.

Sun Mar 15 00:00:00 EDT 2020

DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma.

Journal of cellular and molecular medicine

Song Y,Wang Z,Jiang J,Piao Y,Li L,Xu C,Piao H,Li L,Yan G

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.

Journal of cellular and molecular medicine

Wu R,Liu C,Deng X,Chen L,Hao S,Ma L

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.

Journal of Cancer

Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Effects of combined treatment with PD‑L1 Ig and CD40L mAb on immune tolerance in the CBA/J x DBA/2 mouse model.

Molecular medicine reports

Li G,Yang L,Li D,Zhang J,Du L,Xia L,Liu Y,Hu W

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

Elevated granulocytic myeloid-derived suppressor cells are closely related with elevation of Th17 cells in mice with experimental asthma.

International journal of biological sciences

Xue F,Yu M,Li L,Zhang W,Ma Y,Dong L,Shan W,Zheng Y,Wang T,Feng D,Lv J,Wang X

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Nov 12 00:00:00 EST 2021

Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.

International journal of molecular sciences

Yoon CH,Ryu JS,Hwang HS,Kim MK

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Jun 11 00:00:00 EDT 2020

Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma.

Cells

Martinikova AS,Burocziova M,Stoyanov M,Macurek L

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Sep 10 00:00:00 EDT 2020

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.

JCI insight

Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Aug 20 00:00:00 EDT 2020

FUT1 deficiency elicits immune dysregulation and corneal opacity in steady state and under stress.

Cell death & disease

Kim KW,Ryu JS,Ko JH,Kim JY,Kim HJ,Lee HJ,Oh JH,Chung JH,Oh JY

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Apr 24 00:00:00 EDT 2020

CD8⁺ T Cell Functional Exhaustion Overrides Pregnancy-Induced Fetal Antigen Alloimmunization.

Cell reports

Kinder JM,Turner LH,Stelzer IA,Miller-Handley H,Burg A,Shao TY,Pham G,Way SS

48-0041-82 was used in Immunocytochemistry to demonstrate distinct mechanisms whereby fetal tolerance is maintained during primary compared with subsequent pregnancies.

Tue Jun 23 00:00:00 EDT 2020

The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function.

International journal of molecular sciences

Subbannayya Y,Haug M,Pinto SM,Mohanty V,Meås HZ,Flo TH,Prasad TSK,Kandasamy RK

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Dec 29 00:00:00 EST 2020

Methamphetamine induces cardiomyopathy by Sigmar1 inhibition-dependent impairment of mitochondrial dynamics and function.

Communications biology

Abdullah CS,Aishwarya R,Alam S,Morshed M,Remex NS,Nitu S,Kolluru GK,Traylor J,Miriyala S,Panchatcharam M,Hartman B,King J,Bhuiyan MAN,Chandran S,Woolard MD,Yu X,Goeders NE,Dominic P,Arnold CL,Stokes K,Kevil CG,Orr AW,Bhuiyan MS

48-0041-82 was used in Flow Cytometry to show that Sigmar1 is a therapeutic target for methamphetamine-associated cardiomyopathy.

Tue Nov 17 00:00:00 EST 2020

Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.

PloS one

Hanson A,Elpek K,Duong E,Shallberg L,Fan M,Johnson C,Wallace M,Mabry GR,Sazinsky S,Pepper L,Shu CJ,Sathyanarayanan S,Zuerndorfer S,Simpson T,Gostissa M,Briskin M,Law D,Michaelson J,Harvey CJ

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Nov 16 00:00:00 EST 2020

Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.

Communications biology

Waaler J,Mygland L,Tveita A,Strand MF,Solberg NT,Olsen PA,Aizenshtadt A,Fauskanger M,Lund K,Brinch SA,Lycke M,Dybing E,Nygaard V,Bøe SL,Heintz KM,Hovig E,Hammarström C,Corthay A,Krauss S

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Apr 24 00:00:00 EDT 2020

Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.

Scientific reports

Kedzierska AE,Lorek D,Slawek A,Chelmonska-Soyta A

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Jun 29 00:00:00 EDT 2020

Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.

Frontiers in immunology

Yu Y,Wu DM,Li J,Deng SH,Liu T,Zhang T,He M,Zhao YY,Xu Y

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Jun 21 00:00:00 EDT 2021

Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.

Nature

Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Jul 01 00:00:00 EDT 2019

Intravesical Ty21a Vaccine Promotes Dendritic Cells and T Cell-Mediated Tumor Regression in the MB49 Bladder Cancer Model.

Cancer immunology research

Domingos-Pereira S,Sathiyanadan K,La Rosa S,Polák L,Chevalier MF,Martel P,Hojeij R,Derré L,Haefliger JA,Jichlinski P,Nardelli-Haefliger D

48-0041 was used in Flow cytometry/Cell sorting to demonstrate mechanisms behind intravesical Ty21a therapy and suggest its potential as a safe and effective treatment for NMIBC patients.

Mon Apr 01 00:00:00 EDT 2019

Expression of Bioactive Chemerin by Keratinocytes Inhibits Late Stages of Tumor Development in a Chemical Model of Skin Carcinogenesis.

Frontiers in oncology

Dubois-Vedrenne I,De Henau O,Robert V,Langa F,Javary J,Al Delbany D,Vosters O,Angelats-Canals E,Vernimmen M,Luangsay S,Wittamer V,Parmentier M

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.

Laboratory investigation; a journal of technical methods and pathology

Hensel JA,Khattar V,Ashton R,Ponnazhagan S

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2019

Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.

Laboratory investigation; a journal of technical methods and pathology

Hensel JA,Khattar V,Ashton R,Ponnazhagan S

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2019

Bryostatin-1 ameliorated experimental colitis in Il-10^-/- Mice by protecting the intestinal barrier and limiting immune dysfunction.

Journal of cellular and molecular medicine

Zuo L,Li J,Ge S,Ge Y,Shen M,Wang Y,Zhou C,Wu R,Hu J

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Aug 01 00:00:00 EDT 2019

Lactobacillus rhamnosus GG attenuates tenofovir disoproxil fumarate-induced bone loss in male mice via gut-microbiota-dependent anti-inflammation.

Therapeutic advances in chronic disease

Liu H,Gu R,Li W,Zhou W,Cong Z,Xue J,Liu Y,Wei Q,Zhou Y

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Sat Apr 09 00:00:00 EDT 2022

Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway.

Mediators of inflammation

Xu Y,Tang X,Yang M,Zhang S,Li S,Chen Y,Liu M,Guo Y,Lu M

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Jun 11 00:00:00 EDT 2019

IL-31 plays dual roles in lung inflammation in an OVA-induced murine asthma model.

Biology open

Huang J,Yue H,Jiang T,Gao J,Shi Y,Shi B,Wu X,Gou X

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Jan 15 00:00:00 EST 2019

Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.

Anti-cancer drugs

Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Epithelial EP4 plays an essential role in maintaining homeostasis in colon.

Scientific reports

Matsumoto Y,Nakanishi Y,Yoshioka T,Yamaga Y,Masuda T,Fukunaga Y,Sono M,Yoshikawa T,Nagao M,Araki O,Ogawa S,Goto N,Hiramatsu Y,Breyer RM,Fukuda A,Seno H

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunohistochemistry

Wed Oct 23 00:00:00 EDT 2019

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses.

NPJ vaccines

Li G,Adam A,Luo H,Shan C,Cao Z,Fontes-Garfias CR,Sarathy VV,Teleki C,Winkelmann ER,Liang Y,Sun J,Bourne N,Barrett ADT,Shi PY,Wang T

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Next Generation Sequencing for Long Non-coding RNAs Profile for CD4⁺ T Cells in the Mouse Model of Acute Asthma.

Frontiers in genetics

Wang Z,Ji N,Chen Z,Wu C,Sun Z,Yu W,Hu F,Huang M,Zhang M

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Apr 08 00:00:00 EDT 2022

A non-functional neoepitope specific CD8⁺ T-cell response induced by tumor derived antigen exposure in vivo.

Oncoimmunology

Vormehr M,Reinhard K,Blatnik R,Josef K,Beck JD,Salomon N,Suchan M,Selmi A,Vascotto F,Zerweck J,Wenschuh H,Diken M,Kreiter S,Türeci Ö,Riemer AB,Sahin U

48-0041 was used in Flow cytometry/Cell sorting to investigate neoepitope-specific CD8+ T-cell responses mounted either spontaneously or after immunotherapy regimens in mice bearing tumors of the widely used colon carcinoma cell line CT26.

Tue Jan 12 00:00:00 EST 2021

Sex Differences in Mouse Popliteal Lymph Nodes.

Scientific reports

Dill-Garlow R,Chen KE,Walker AM

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Jan 30 00:00:00 EST 2019

Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation.

Cell reports

Ciecko AE,Foda B,Barr JY,Ramanathan S,Atkinson MA,Serreze DV,Geurts AM,Lieberman SM,Chen YG

48-0041-82 was used in Flow Cytometry to reveal that IL-27 contributes to autoimmunity in NOD mice through multiple mechanisms and provides substantial evidence to support its pathogenic role in human T1D.

Tue Dec 03 00:00:00 EST 2019

TLR1/2 Specific Small-Molecule Agonist Suppresses Leukemia Cancer Cell Growth by Stimulating Cytotoxic T Lymphocytes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cen X,Zhu G,Yang J,Yang J,Guo J,Jin J,Nandakumar KS,Yang W,Yin H,Liu S,Cheng K

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri May 17 00:00:00 EDT 2019

Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells.

JCI insight

Huang A,Shinde PV,Huang J,Senff T,Xu HC,Margotta C,Häussinger D,Willnow TE,Zhang J,Pandyra AA,Timm J,Weggen S,Lang KS,Lang PA

48-0041 was used in Flow cytometry/Cell sorting to show that progranulin (PGRN) can reduce NK cell cytotoxicity through reduction of NK cell expansion, granzyme B transcription, and NK cell-mediated lysis of target cells.

Thu Sep 05 00:00:00 EDT 2019

Persistence of Integrase-Deficient Lentiviral Vectors Correlates with the Induction of STING-Independent CD8⁺ T Cell Responses.

Cell reports

Cousin C,Oberkampf M,Felix T,Rosenbaum P,Weil R,Fabrega S,Morante V,Negri D,Cara A,Dadaglio G,Leclerc C

48-0041 was used in Flow cytometry/Cell sorting to demonstrate that integrase-deficient lentiviral vectors can trigger persistent adaptive response by the mediation of a weak and transient innate response alongside the persistence of the vector in tissues.

Tue Jan 29 00:00:00 EST 2019

Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles.

Cell reports

Cianciaruso C,Beltraminelli T,Duval F,Nassiri S,Hamelin R,Mozes A,Gallart-Ayala H,Ceada Torres G,Torchia B,Ries CH,Ivanisevic J,De Palma M

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Jun 04 00:00:00 EDT 2019

Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A.

Immunity

Wang M,Zhang S,Zheng G,Huang J,Songyang Z,Zhao X,Lin X

48-0041 was used in Flow cytometry/Cell sorting to show CARMA2 serves as a key mediator of IL-17A signaling and its constitutive activation in keratinocytes leads to the onset of psoriasis.

Tue Jul 17 00:00:00 EDT 2018

Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells.

Immunity

Halim TYF,Rana BMJ,Walker JA,Kerscher B,Knolle MD,Jolin HE,Serrao EM,Haim-Vilmovsky L,Teichmann SA,Rodewald HR,Botto M,Vyse TJ,Fallon PG,Li Z,Withers DR,McKenzie ANJ

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Jun 19 00:00:00 EDT 2018

PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy.

The Journal of clinical investigation

Zamarin D,Ricca JM,Sadekova S,Oseledchyk A,Yu Y,Blumenschein WM,Wong J,Gigoux M,Merghoub T,Wolchok JD

48-0041 was used in Flow cytometry/Cell sorting to use human tumour histocultures and syngeneic tumour models treated with Newcastle disease virus to identify immune targets upregulated by OV treatment.

Mon Apr 02 00:00:00 EDT 2018

Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling.

The Journal of clinical investigation

Emmerson A,Trevelin SC,Mongue-Din H,Becker PD,Ortiz C,Smyth LA,Peng Q,Elgueta R,Sawyer G,Ivetic A,Lechler RI,Lombardi G,Shah AM

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Jul 02 00:00:00 EDT 2018

PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8⁺ T-Cell-Driven Antitumor Immunity.

Clinical cancer research : an official journal of the American Association for Cancer Research

Buchan SL,Fallatah M,Thirdborough SM,Taraban VY,Rogel A,Thomas LJ,Penfold CA,He LZ,Curran MA,Keler T,Al-Shamkhani A

48-0041 was used in Flow cytometry/Cell sorting to show that suboptimal T-cell invigoration in cancer patients undergoing treatment with PD-1 checkpoint blockers will be improved by dual PD-1 blockade and CD27 agonism.

Tue May 15 00:00:00 EDT 2018

Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.

Molecular therapy : the journal of the American Society of Gene Therapy

Ricca JM,Oseledchyk A,Walther T,Liu C,Mangarin L,Merghoub T,Wolchok JD,Zamarin D

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Apr 04 00:00:00 EDT 2018

Role of TFH Cells in Promoting T Helper 17-Induced Neuroinflammation.

Frontiers in immunology

Quinn JL,Kumar G,Agasing A,Ko RM,Axtell RC

48-0041 was used in Flow cytometry/Cell sorting to study how T and B cells cooperate in the pathogenesis of multiple sclerosis.

Mon Apr 08 00:00:00 EDT 2019

Murine CMV induces type 1 IFN that impairs differentiation of MDSCs critical for transplantation tolerance.

Blood advances

Dangi A,Zhang L,Zhang X,Luo X

48-0041 was used in Flow cytometry/Cell sorting to provide a solid foundation for seeking effective therapies for promoting transplantation tolerance in settings of CMV infection.

Tue Mar 27 00:00:00 EDT 2018

MicroRNA-126 deficiency enhanced the activation and function of CD4⁺ T cells by elevating IRS-1 pathway.

Clinical and experimental immunology

Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells.

World journal of gastroenterology

Müller-Graff FT,Fitzner B,Jaster R,Vollmar B,Zechner D

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Sat Jul 28 00:00:00 EDT 2018

Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.

Evidence-based complementary and alternative medicine : eCAM

Pang P,Zheng K,Wu S,Xu H,Deng L,Shi Y,Chen X

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma.

Nature communications

Lorentsen KJ,Cho JJ,Luo X,Zuniga AN,Urban JF,Zhou L,Gharaibeh R,Jobin C,Kladde MP,Avram D

48-0041-82 was used in Flow Cytometry to establish novel roles for Bcl11b in the regulatory loop that licenses Th2 program in vivo.

Thu Apr 26 00:00:00 EDT 2018

Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.

Nature communications

Xu Y,Ikeda S,Sumida K,Yamamoto R,Tanaka H,Minato N

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Mar 02 00:00:00 EST 2018

Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.

JCI insight

McCall CE,Zabalawi M,Liu T,Martin A,Long DL,Buechler NL,Arts RJW,Netea M,Yoza BK,Stacpoole PW,Vachharajani V

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Aug 09 00:00:00 EDT 2018

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.

eLife

Lian G,Gnanaprakasam JR,Wang T,Wu R,Chen X,Liu L,Shen Y,Yang M,Yang J,Chen Y,Vasiliou V,Cassel TA,Green DR,Liu Y,Fan TW,Wang R

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Sep 10 00:00:00 EDT 2018

STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia.

Cell reports

Saint Fleur-Lominy S,Maus M,Vaeth M,Lange I,Zee I,Suh D,Liu C,Wu X,Tikhonova A,Aifantis I,Feske S

48-0041 was used in Flow cytometry/Cell sorting to investigate the role of store-operated Ca2+ entry mediated by ORAI1, and STIM1 and STIM2 in T-cell acute lymphoblastic leukaemia.

Tue Sep 11 00:00:00 EDT 2018

A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.

Nature communications

Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Apr 18 00:00:00 EDT 2018

Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Peng J,Xiao Y,Li W,Yang Q,Tan L,Jia Y,Qu Y,Qian Z

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue May 01 00:00:00 EDT 2018

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.

eLife

Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Nov 20 00:00:00 EST 2018

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.

Journal of neuroinflammation

Unger MS,Schernthaner P,Marschallinger J,Mrowetz H,Aigner L

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Sep 21 00:00:00 EDT 2018

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.

Journal of neuroinflammation

Unger MS,Schernthaner P,Marschallinger J,Mrowetz H,Aigner L

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Sep 21 00:00:00 EDT 2018

MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity.

Frontiers in immunology

Knolle MD,Chin SB,Rana BMJ,Englezakis A,Nakagawa R,Fallon PG,Git A,McKenzie ANJ

48-0041 was used in Flow cytometry/Cell sorting to identify a subset of micro-RNAs that are regulated upon group-2 innate lymphoid cells (ILC2) activation, and establish a specific role for miR-155 in regulating ILC2 survival following activation.

Mon Sep 30 00:00:00 EDT 2019

Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung.

Frontiers in physiology

Lim D,Kim W,Lee C,Bae H,Kim J

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Plasmodium co-infection protects against chikungunya virus-induced pathologies.

Nature communications

Teo TH,Lum FM,Ghaffar K,Chan YH,Amrun SN,Tan JJL,Lee CYP,Chua TK,Carissimo G,Lee WWL,Claser C,Rajarethinam R,Rénia L,Ng LFP

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Sep 25 00:00:00 EDT 2018

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects.

Journal of experimental & clinical cancer research : CR

Xu L,Zhang Y,Tian K,Chen X,Zhang R,Mu X,Wu Y,Wang D,Wang S,Liu F,Wang T,Zhang J,Liu S,Zhang Y,Tu C,Liu H

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Oct 29 00:00:00 EDT 2018

Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice.

mSphere

Quach D,Collins F,Parameswaran N,McCabe L,Britton RA

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

Store-Operated Ca²⁺ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.

Immunity

Vaeth M,Maus M,Klein-Hessling S,Freinkman E,Yang J,Eckstein M,Cameron S,Turvey SE,Serfling E,Berberich-Siebelt F,Possemato R,Feske S

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity.

Cell metabolism

Westerterp M,Gautier EL,Ganda A,Molusky MM,Wang W,Fotakis P,Wang N,Randolph GJ,D'Agati VD,Yvan-Charvet L,Tall AR

48-0041 was used in Flow cytometry/Cell sorting to identify an essential role of DC cholesterol efflux pathways in maintaining immune tolerance.

Tue Jun 06 00:00:00 EDT 2017

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.

The Journal of clinical investigation

Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

The Journal of experimental medicine

Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Jun 05 00:00:00 EDT 2017

Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination.

Cancer research

Jiang H,Rivera-Molina Y,Gomez-Manzano C,Clise-Dwyer K,Bover L,Vence LM,Yuan Y,Lang FF,Toniatti C,Hossain MB,Fueyo J

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Sat Jul 15 00:00:00 EDT 2017

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

Proceedings of the National Academy of Sciences of the United States of America

Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Mar 21 00:00:00 EDT 2017

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

Proceedings of the National Academy of Sciences of the United States of America

Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Mar 21 00:00:00 EDT 2017

Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.

Acta pharmacologica Sinica

Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Cornea lymphatics drive the CD8⁺ T-cell response to herpes simplex virus-1.

Immunology and cell biology

Gurung HR,Carr MM,Carr DJ

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2017

ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.

RNA biology

Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu May 04 00:00:00 EDT 2017

Calreticulin is an effective immunologic adjuvant to tumor-associated antigens.

Experimental and therapeutic medicine

Wang J,Gao ZP,Qin S,Liu CB,Zou LL

48-0041 was used in Flow cytometry/Cell sorting to examine whether calreticulin is able to act as an immunologic adjuvant and translocate itself and tumour-associated antigens to the cell surface to induce a specific anti-tumour immune response.

Sun Oct 01 00:00:00 EDT 2017

Adeno-associated virus serotype rh.10 displays strong muscle tropism following intraperitoneal delivery.

Scientific reports

Ai J,Li J,Gessler DJ,Su Q,Wei Q,Li H,Gao G

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunofluorescence

Mon Jan 09 00:00:00 EST 2017

Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated with Suppressed Inflammatory Transcriptional Networks in the Mouse Colon.

Frontiers in physiology

Yang T,Ahmari N,Schmidt JT,Redler T,Arocha R,Pacholec K,Magee KL,Malphurs W,Owen JL,Krane GA,Li E,Wang GP,Vickroy TW,Raizada MK,Martyniuk CJ,Zubcevic J

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunofluorescence

Thu Oct 01 00:00:00 EDT 2020

Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease.

Scientific reports

Ogawa Y,He H,Mukai S,Imada T,Nakamura S,Su CW,Mahabole M,Tseng SC,Tsubota K

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunohistochemistry

Mon Feb 06 00:00:00 EST 2017

Location of tumor affects local and distant immune cell type and number.

Immunity, inflammation and disease

Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury.

Stem cell research & therapy

Zhu D,Tan J,Maleken AS,Muljadi R,Chan ST,Lau SN,Elgass K,Leaw B,Mockler J,Chambers D,Leeman KT,Kim CF,Wallace EM,Lim R

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Nov 10 00:00:00 EST 2017

Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.

Scientific reports

Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H

48-0041 was used in Flow cytometry/Cell sorting to investigate the effect Paeoniflorin has on Th cells and dendritic cells in a mouse MS model.

Mon Feb 06 00:00:00 EST 2017

MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis.

Stem cell reports

Shigemoto-Kuroda T,Oh JY,Kim DK,Jeong HJ,Park SY,Lee HJ,Park JW,Kim TW,An SY,Prockop DJ,Lee RH

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue May 09 00:00:00 EDT 2017

Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mice by Selectively Altering the Gut Microbiota and Promoting Intestinal Gamma-Delta T Cells.

Frontiers in pharmacology

Li M,Gao J,Tang Y,Liu M,Wu S,Qu K,Long X,Li H,Liu M,Liu Y,Yuan J,Mao L,Liu Y,Zheng X,Wang E,Wang J,Yang Y

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies.

PloS one

Min M,Yan BX,Wang P,Landeck L,Chen JQ,Li W,Cai SQ,Zheng M,Man XY

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Jan 16 00:00:00 EST 2018

Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.

Oncoimmunology

Huang RY,Francois A,McGray AR,Miliotto A,Odunsi K

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.

JCI insight

Azzam KM,Madenspacher JH,Cain DW,Lai L,Gowdy KM,Rai P,Janardhan K,Clayton N,Cunningham W,Jensen H,Patel PS,Kearney JF,Taylor GA,Fessler MB

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Aug 17 00:00:00 EDT 2017

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.

Nature communications

Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP

Mon Feb 13 00:00:00 EST 2017

A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation.

EBioMedicine

Ma J,Teng X,Wang X,Fan X,Wu Y,Tian M,Zhou Z,Li L

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Cell

Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Oct 06 00:00:00 EDT 2016

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq.

Cell

Jaitin DA,Weiner A,Yofe I,Lara-Astiaso D,Keren-Shaul H,David E,Salame TM,Tanay A,van Oudenaarden A,Amit I

48-0041 was used in Flow cytometry/Cell sorting to establish CRISP-seq as a broadly applicable, comprehensive, and unbiased approach for elucidating mammalian regulatory circuits.

Thu Dec 15 00:00:00 EST 2016

Foxp3 and Toll-like receptor signaling balance T_reg cell anabolic metabolism for suppression.

Nature immunology

Gerriets VA,Kishton RJ,Johnson MO,Cohen S,Siska PJ,Nichols AG,Warmoes MO,de Cubas AA,MacIver NJ,Locasale JW,Turka LA,Wells AD,Rathmell JC

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2016

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.

Immunology

Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2016

p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.

European journal of immunology

Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Mast cell depletion in the preclinical phase of collagen-induced arthritis reduces clinical outcome by lowering the inflammatory cytokine profile.

Arthritis research & therapy

van der Velden D,Lagraauw HM,Wezel A,Launay P,Kuiper J,Huizinga TW,Toes RE,Bot I,Stoop JN

48-0041 was used in Flow cytometry/Cell sorting to suggest that mast cells may play a role in the regulation of the adaptive immune response during the development of arthritis.

Mon Jun 13 00:00:00 EDT 2016

Multispectral Imaging of T and B Cells in Murine Spleen and Tumor.

Journal of immunology (Baltimore, Md. : 1950)

Feng Z,Jensen SM,Messenheimer DJ,Farhad M,Neuberger M,Bifulco CB,Fox BA

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunofluorescence

Sun May 01 00:00:00 EDT 2016

Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.

Journal of immunology (Baltimore, Md. : 1950)

Menendez CM,Jinkins JK,Carr DJ

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Aug 15 00:00:00 EDT 2016

Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.

Molecular medicine reports

Gu L,Deng WS,Sun XF,Zhou H,Xu Q

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.

Biology open

Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Sun May 15 00:00:00 EDT 2016

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.

Nature communications

Brinkman CC,Iwami D,Hritzo MK,Xiong Y,Ahmad S,Simon T,Hippen KL,Blazar BR,Bromberg JS

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Jun 21 00:00:00 EDT 2016

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.

Nature communications

Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Jun 08 00:00:00 EDT 2016

Interleukin-10 deficiency impairs regulatory T cell-derived neuropilin-1 functions and promotes Th1 and Th17 immunity.

Scientific reports

Wang S,Gao X,Shen G,Wang W,Li J,Zhao J,Wei YQ,Edwards CK

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Apr 14 00:00:00 EDT 2016

NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.

Nature communications

Alrefai H,Muhammad K,Rudolf R,Pham DA,Klein-Hessling S,Patra AK,Avots A,Bukur V,Sahin U,Tenzer S,Goebeler M,Kerstan A,Serfling E

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed May 25 00:00:00 EDT 2016

Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice.

BMC complementary and alternative medicine

Zhang S,Liu X,Mei L,Wang H,Fang F

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Aug 31 00:00:00 EDT 2016

Flagellin is a strong vaginal adjuvant of a therapeutic vaccine for genital cancer.

Oncoimmunology

Lee SE,Hong SH,Verma V,Lee YS,Duong TN,Jeong K,Uthaman S,Sung YC,Lee JT,Park IK,Min JJ,Rhee JH

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2016

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms.

Cell reports

Choi IY,Piccio L,Childress P,Bollman B,Ghosh A,Brandhorst S,Suarez J,Michalsen A,Cross AH,Morgan TE,Wei M,Paul F,Bock M,Longo VD

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Jun 07 00:00:00 EDT 2016

TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection.

Cell reports

Schleicher U,Paduch K,Debus A,Obermeyer S,König T,Kling JC,Ribechini E,Dudziak D,Mougiakakos D,Murray PJ,Ostuni R,Körner H,Bogdan C

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue May 03 00:00:00 EDT 2016

Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.

Scientific reports

Ochi T,Feng Y,Kitamoto S,Nagao-Kitamoto H,Kuffa P,Atarashi K,Honda K,Teitelbaum DH,Kamada N

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Jun 15 00:00:00 EDT 2016

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Nature

Huang YH,Zhu C,Kondo Y,Anderson AC,Gandhi A,Russell A,Dougan SK,Petersen BS,Melum E,Pertel T,Clayton KL,Raab M,Chen Q,Beauchemin N,Yazaki PJ,Pyzik M,Ostrowski MA,Glickman JN,Rudd CE,Ploegh HL,Franke A,Petsko GA,Kuchroo VK,Blumberg RS

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Jan 15 00:00:00 EST 2015

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.

Nature biotechnology

Kim J,Li WA,Choi Y,Lewin SA,Verbeke CS,Dranoff G,Mooney DJ

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2015

Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner.

Blood

Yi W,Hu X,Chen Z,Liu L,Tian Y,Chen H,Cong YS,Yang F,Zhang L,Rudolph KL,Zhang Z,Zhao Y,Ju Z

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Jul 30 00:00:00 EDT 2015

IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.

The Journal of experimental medicine

Pallangyo CK,Ziegler PK,Greten FR

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Dec 14 00:00:00 EST 2015

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Developmental cell

Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunofluorescence

Mon Sep 14 00:00:00 EDT 2015

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Developmental cell

Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunofluorescence

Mon Sep 14 00:00:00 EDT 2015

B cell autophagy mediates TLR7-dependent autoimmunity and inflammation.

Autophagy

Weindel CG,Richey LJ,Bolland S,Mehta AJ,Kearney JF,Huber BT

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunohistochemistry

Mon Apr 18 00:00:00 EDT 2016

IFN-γ ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation.

Proceedings of the National Academy of Sciences of the United States of America

Sosa RA,Murphey C,Robinson RR,Forsthuber TG

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunofluorescence

Tue Sep 08 00:00:00 EDT 2015

Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.

Cell death and differentiation

Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

Mice lacking Axl and Mer tyrosine kinase receptors are susceptible to experimental autoimmune orchitis induction.

Immunology and cell biology

Li N,Liu Z,Zhang Y,Chen Q,Liu P,Cheng CY,Lee WM,Chen Y,Han D

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2015

B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses.

Journal of immunology (Baltimore, Md. : 1950)

Pone EJ,Lam T,Lou Z,Wang R,Chen Y,Liu D,Edinger AL,Xu Z,Casali P

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2015

Unexpected Role for Adaptive αβTh17 Cells in Acute Respiratory Distress Syndrome.

Journal of immunology (Baltimore, Md. : 1950)

Li JT,Melton AC,Su G,Hamm DE,LaFemina M,Howard J,Fang X,Bhat S,Huynh KM,O'Kane CM,Ingram RJ,Muir RR,McAuley DF,Matthay MA,Sheppard D

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2015

Histone deacetylation of memory T lymphocytes by You-Gui-Wan alleviates allergen-induced eosinophilic airway inflammation in asthma.

Chinese medicine

Zhang HP,Fu JJ,Fan T,Zhang WB,Wang ZL,Wang L,Wang G

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Jun 15 00:00:00 EDT 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Sep 15 00:00:00 EDT 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Sep 15 00:00:00 EDT 2015

Mannan-modified adenovirus targeting TERT and VEGFR-2: A universal tumour vaccine.

Scientific reports

Wang Y,Zhang J,Wu Y,Ding ZY,Luo XM,Liu J,Zhong WN,Deng GH,Xia XY,Deng YT,Wei YQ,Jiang Y

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Jun 18 00:00:00 EDT 2015

Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.

Cell transplantation

Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Nov 16 00:00:00 EST 2015

Intranasal Administration of Lentiviral miR-135a Regulates Mast Cell and Allergen-Induced Inflammation by Targeting GATA-3.

PloS one

Deng YQ,Yang YQ,Wang SB,Li F,Liu MZ,Hua QQ,Tao ZZ

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue May 31 00:00:00 EDT 2016

Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses.

Stem cell reports

Wang WB,Yen ML,Liu KJ,Hsu PJ,Lin MH,Chen PM,Sudhir PR,Chen CH,Chen CH,Sytwu HK,Yen BL

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Sep 08 00:00:00 EDT 2015

Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.

Autophagy

Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Jul 01 00:00:00 EDT 2014

Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.

PLoS pathogens

Ataide MA,Andrade WA,Zamboni DS,Wang D,Souza Mdo C,Franklin BS,Elian S,Martins FS,Pereira D,Reed G,Fitzgerald KA,Golenbock DT,Gazzinelli RT

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2014

Preemptive donor apoptotic cell infusions induce IFN-γ-producing myeloid-derived suppressor cells for cardiac allograft protection.

Journal of immunology (Baltimore, Md. : 1950)

Bryant J,Lerret NM,Wang JJ,Kang HK,Tasch J,Zhang Z,Luo X

48-0041 was used in Flow cytometry/Cell sorting to investigate the role of MDSCs in the graft protection provided by ECDI-SPs, showing that preemptive donor apoptotic cell infusions induce IFN-γ-producing MDSCs.

Sun Jun 15 00:00:00 EDT 2014

Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection.

Journal of immunology (Baltimore, Md. : 1950)

Jie Z,Liang Y,Hou L,Dong C,Iwakura Y,Soong L,Cong Y,Sun J

48-0041 was used in Flow cytometry/Cell sorting to investigate the source and regulation of the IL-17 surge in the liver microenvironment that occurs early in the response to viral infection.

Tue Apr 01 00:00:00 EDT 2014

Regulation of cyp26a1 on Th17 cells in mouse peri-implantation.

Journal of cellular and molecular medicine

Liu HY,Chao H,Liu ZK,Xia HF,Song Z,Yang Y,Peng JP

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Sat Mar 01 00:00:00 EST 2014

Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.

Human vaccines & immunotherapeutics

Wang S,Wu B,Xue J,Wang M,Chen R,Wang B

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Jan 05 00:00:00 EST 2015

An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection.

Genes and immunity

Lafferty EI,Flaczyk A,Angers I,Homer R,d'Hennezel E,Malo D,Piccirillo CA,Vidal SM,Qureshi ST

48-0041 was used in Flow cytometry/Cell sorting to establish a role for Unc93b1 and endosomal TLRs in the activation of both myeloid and lymphoid cells during the innate immune response to influenza.

Fri Apr 10 00:00:00 EDT 2015

High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Somatostatin inhibits the production of interferon-γ by intestinal epithelial cells during intestinal ischemia-reperfusion in macaques.

Digestive diseases and sciences

Liu L,Tan Q,Hu B,Wu H,Wang C,Tang C

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunohistochemistry

Wed Oct 01 00:00:00 EDT 2014

Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects.

BMC cancer

Tian H,Shi G,Yang G,Zhang J,Li Y,Du T,Wang J,Xu F,Cheng L,Zhang X,Dai L,Chen X,Zhang S,Yang Y,Yu D,Wei Y,Deng H

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Jan 29 00:00:00 EST 2014

Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects.

BMC cancer

Tian H,Shi G,Yang G,Zhang J,Li Y,Du T,Wang J,Xu F,Cheng L,Zhang X,Dai L,Chen X,Zhang S,Yang Y,Yu D,Wei Y,Deng H

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Jan 29 00:00:00 EST 2014

Conditional deletion of ferritin h in mice reduces B and T lymphocyte populations.

PloS one

Vanoaica L,Richman L,Jaworski M,Darshan D,Luther SA,Kühn LC

48-0041 was used in Flow cytometry/Cell sorting to investigate the effect of ferritin H deletion on lymphocytes, showing that it reduces B and T lymphocyte populations.

Tue Jan 13 00:00:00 EST 2015

A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking β-glucans.

PloS one

Dong B,Li D,Li R,Chen SC,Liu W,Liu W,Chen L,Chen Y,Zhang X,Tong Z,Xia Y,Xia P,Wang Y,Duan Y

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2015

Neutrophils contribute to excess serum BAFF levels and promote CD4+ T cell and B cell responses in lupus-prone mice.

PloS one

Coquery CM,Wade NS,Loo WM,Kinchen JM,Cox KM,Jiang C,Tung KS,Erickson LD

48-0041 was used in Flow cytometry/Cell sorting to analyse the phenotype, localisation and function of neutrophils in the spleens of healthy mice and congenic lupus-prone mice.

Fri Nov 06 00:00:00 EST 2015

Intravaginal TLR agonists increase local vaccine-specific CD8 T cells and human papillomavirus-associated genital-tumor regression in mice.

Mucosal immunology

Domingos-Pereira S,Decrausaz L,Derré L,Bobst M,Romero P,Schiller JT,Jichlinski P,Nardelli-Haefliger D

48-0041 was used in Flow cytometry/Cell sorting to study the immune effects of the instillation of Toll-like receptor agonists after subcutaneous E7 vaccination.

Fri Mar 01 00:00:00 EST 2013

Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.

Development (Cambridge, England)

Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2013

A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).

Disease models & mechanisms

Carofino BL,Ayanga B,Justice MJ

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Nov 01 00:00:00 EDT 2013

Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice.

Human vaccines & immunotherapeutics

Wu B,Zou Q,Hu Y,Wang B

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2013

The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine.

PloS one

Radulovic K,Rossini V,Manta C,Holzmann K,Kestler HA,Niess JH

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunofluorescence

Thu Jan 23 00:00:00 EST 2014

The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine.

PloS one

Radulovic K,Rossini V,Manta C,Holzmann K,Kestler HA,Niess JH

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunofluorescence

Thu Jan 23 00:00:00 EST 2014

Enhanced immune response against HIV-1 induced by a heterologous DNA prime-adenovirus boost vaccination using mannosylated polyethyleneimine as DNA vaccine adjuvant.

International journal of nanomedicine

Li M,Jiang Y,Xu C,Zhang Z,Sun X

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Wed Apr 02 00:00:00 EDT 2014

Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.

PloS one

Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Jul 31 00:00:00 EDT 2014

Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.

PloS one

Gong Y,Wang Z,Liang Z,Duan H,Ouyang L,Yu Q,Xu Z,Shen G,Weng X,Wu X

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Fri Jul 19 00:00:00 EDT 2013

Negative selection assay based on stimulation of T cell receptor transgenic thymocytes with peptide-MHC tetramers.

PloS one

Rybakin V,Gascoigne NR

48-0041 was used in Flow cytometry/Cell sorting to develop an assay for the induction of negative selection based on stimulation of T cell receptor transgenic thymocytes with peptide-MHC tetramers.

Fri Mar 22 00:00:00 EDT 2013

Rapamycin ameliorates dystrophic phenotype in mdx mouse skeletal muscle.

Molecular medicine (Cambridge, Mass.)

Eghtesad S,Jhunjhunwala S,Little SR,Clemens PR

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunohistochemistry

Sun Mar 25 00:00:00 EDT 2012

T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.

Journal of immunology (Baltimore, Md. : 1950)

Wang R,Xie H,Huang Z,Ma J,Fang X,Ding Y,Sun Z

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2011

Effects of irradiating adult mdx mice before full-length dystrophin cDNA transfer on host anti-dystrophin immunity.

Gene therapy

Eghtesad S,Zheng H,Nakai H,Epperly MW,Clemens PR

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Immunohistochemistry

Wed Sep 01 00:00:00 EDT 2010

Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.

Investigative ophthalmology & visual science

Mochimaru H,Usui T,Yaguchi T,Nagahama Y,Hasegawa G,Usui Y,Shimmura S,Tsubota K,Amano S,Kawakami Y,Ishida S

Thu May 01 00:00:00 EDT 2008

Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.

Circulation

Yang Z,Day YJ,Toufektsian MC,Xu Y,Ramos SI,Marshall MA,French BA,Linden J

Tue Nov 07 00:00:00 EST 2006

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis.

Proceedings of the National Academy of Sciences of the United States of America

Woolf E,Xiao C,Fainaru O,Lotem J,Rosen D,Negreanu V,Bernstein Y,Goldenberg D,Brenner O,Berke G,Levanon D,Groner Y

Published figure using CD4 monoclonal antibody (Product # 48-0041-82) in Flow Cytometry

Tue Jun 24 00:00:00 EDT 2003

Bioinformatics

Protein Aliases: CD4; CD4 antigen p55; cd4a; fCD4; Leu-3; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4)

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Gene Aliases: Cd4; L3T4; Ly-4

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UniProt ID: (Mouse) P06332

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Entrez Gene ID: (Mouse) 12504

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Function(s)

glycoprotein binding protein binding zinc ion binding coreceptor activity enzyme binding protein kinase binding protein homodimerization activity

Process(es)

cytokine production immune system process induction by virus of host cell-cell fusion immune response cell adhesion cell surface receptor signaling pathway T cell differentiation maintenance of protein location in cell T cell activation T cell selection protein palmitoleylation positive regulation of protein kinase activity positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-negative bacterium positive regulation of calcium-mediated signaling regulation of T cell activation positive regulation of T cell activation

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CD4 Monoclonal Antibody (GK1.5), eFluor™ 450, eBioscience™

CD4 Antibody (48-0041-82) in Flow

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48-0041-82

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