Product References
Polycomb Bodies Detection in Murine Fibromuscular Stroma from Skin, Skeletal Muscles, and Aortic Tissues.
Methods in molecular biology (Clifton, N.J.)
Rosti V,Gorini F,Santarelli P,Sarnicola ML,Magnani S,Lanzuolo C
48-0451-82 was used in Flow cytometry/Cell sorting to combine a fluorescence-activated cell sorter (FACS)-based method with an immunofluorescence staining.
Wed May 24 00:00:00 EDT 2023
Sexually dimorphic extracellular vesicle responses after chronic spinal cord injury are associated with neuroinflammation and neurodegeneration in the aged brain.
Journal of neuroinflammation
Li Y,Khan N,Ritzel RM,Lei Z,Allen S,Faden AI,Wu J
48-0451-82 was used in Flow cytometry/Cell sorting to investigate the impact of biological sex and aging on extracellular vesicles and brain after spinal cord injury.
Thu Aug 31 00:00:00 EDT 2023
Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms.
NPJ Regenerative medicine
Liu X,Han M,Weng W,Li Y,Pu W,Liu K,Li X,He L,Sun R,Shen R,He Y,Liang D,Chen YH,Wang QD,Tchorz JS,Zhou B
48-0451-82 was used in Flow cytometry/Cell sorting to generat Cre-activated functional ProTracer (fProTracer) mice, which enable simultaneous recording of cell proliferation and tissue-specific gene deletion, facilitating broad functional analysis of cell proliferation by any Cre driver.
Thu Aug 03 00:00:00 EDT 2023
Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants.
Nature chemical biology
Zhang L,Dutta S,Xiong S,Chan M,Chan KK,Fan TM,Bailey KL,Lindeblad M,Cooper LM,Rong L,Gugliuzza AF,Shukla D,Procko E,Rehman J,Malik AB
48-0451-82 was used in Flow Cytometry to demonstrate broad efficacy in vivo of an engineered ACE2 decoy against SARS-CoV-2 variants in mice and point to its therapeutic potential.
Tue Mar 01 00:00:00 EST 2022
Impairment of autophagy after spinal cord injury potentiates neuroinflammation and motor function deficit in mice.
Theranostics
Li Y,Lei Z,Ritzel RM,He J,Li H,Choi HMC,Lipinski MM,Wu J
48-0451-82 was used in Flow cytometry/Cell sorting to highlight the importance of autophagy in spinal cord microglia and its role in secondary injury after SCI.
Tue Aug 02 00:00:00 EDT 2022
Overexpression of mir-135b and mir-210 in mesenchymal stromal cells for the enrichment of extracellular vesicles with angiogenic factors.
PloS one
Vieira JMF,Zamproni LN,Wendt CHC,Rocha de Miranda K,Lindoso RS,Won Han S
48-0451-82 was used in Flow cytometry/Cell sorting to show that extracellular vesicle cargo can be modified by lentiviral vectors to enrich specific miRNAs to achieve a specific angiogenic potential.
Thu Aug 18 00:00:00 EDT 2022
Defined conditions for long-term expansion of murine and human alveolar epithelial stem cells in three-dimensional cultures.
STAR protocols
Konishi S,Tata A,Tata PR
48-0451-82 was used in Flow cytometry/Cell sorting to describe a detailed protocol for the isolation, purification, and culture of murine and human AT2s.
Fri Jun 17 00:00:00 EDT 2022
Nucleolin Therapeutic Targeting Decreases Pancreatic Cancer Immunosuppression.
Cancers
Ponzo M,Debesset A,Cossutta M,Chalabi-Dchar M,Houppe C,Pilon C,Nicolas-Boluda A,Meunier S,Raineri F,Thiolat A,Nicolle R,Maione F,Brundu S,Cojocaru CF,Bouvet P,Bousquet C,Gazeau F,Tournigand C,Courty J,Giraudo E,Cohen JL,Cascone I
48-0451-82 was used in Flow cytometry/Cell sorting to show that nucleolin (NCL) inhibition normalizes tumour vessels and impairs PDAC growth.
Wed Aug 31 00:00:00 EDT 2022
CD11bhigh B Cells Increase after Stroke and Regulate Microglia.
Journal of immunology (Baltimore, Md. : 1950)
Korf JM,Honarpisheh P,Mohan EC,Banerjee A,Blasco-Conesa MP,Honarpisheh P,Guzman GU,Khan R,Ganesh BP,Hazen AL,Lee J,Kumar A,McCullough LD,Chauhan A
48-0451-82 was used in Flow cytometry/Cell sorting to investigate the role of CD11bhigh B cells in immune responses after stroke in young and aged mice.
Fri Jul 15 00:00:00 EDT 2022
Neoantigen cancer vaccine augments anti-CTLA-4 efficacy.
NPJ vaccines
Salvatori E,Lione L,Compagnone M,Pinto E,Conforti A,Ciliberto G,Aurisicchio L,Palombo F
48-0451-82 was used in Flow Cytometry to support the use of NCV delivered by DNA-EP with αCTLA-4 and suggest a new combined therapy for clinical testing.
Wed Feb 02 00:00:00 EST 2022
STAT1 Contributes to Microglial/Macrophage Inflammation and Neurological Dysfunction in a Mouse Model of Traumatic Brain Injury.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhao Y,Ma C,Chen C,Li S,Wang Y,Yang T,Stetler RA,Bennett MVL,Dixon CE,Chen J,Shi Y
48-0451-82 was used in Flow cytometry/Cell sorting to show excellent efficacy of a selective STAT1 inhibitor fludarabine against TBI-induced functional deficits and brain injury using a mouse model, presenting STAT1 as a promising therapeutic target for TBI.
Wed Sep 28 00:00:00 EDT 2022
Activated Neutrophils Secrete Chitinase-Like 1 and Attenuate Liver Inflammation by Inhibiting Pro-Inflammatory Macrophage Responses.
Frontiers in immunology
Lu Y,Chang N,Zhao X,Xue R,Liu J,Yang L,Li L
48-0451-82 was used in Flow cytometry/Cell sorting to indicate that A-Neu could inhibit the pro-inflammatory macrophage responses by secreting CHIL1, thereby effectively inhibiting liver inflammation.
Tue May 10 00:00:00 EDT 2022
Fate mapping and scRNA sequencing reveal origin and diversity of lymph node stromal precursors.
Immunity
Lenti E,Genovese L,Bianchessi S,Maurizio A,Sain SB,di Lillo A,Mattavelli G,Harel I,Bernassola F,Hehlgans T,Pfeffer K,Crosti M,Abrignani S,Evans SM,Sitia G,Guimarães-Camboa N,Russo V,van de Pavert SA,Garcia-Manteiga JM,Brendolan A
48-0451-82 was used in Immunohistochemistry (Frozen) to identify the earliest embryonic sources of LN stromal and endothelial cells and demonstrates that stromal diversity begins already during LN development.
Tue Apr 12 00:00:00 EDT 2022
The voltage-gated proton channel Hv1 plays a detrimental role in contusion spinal cord injury via extracellular acidosis-mediated neuroinflammation.
Brain, behavior, and immunity
Li Y,Ritzel RM,He J,Cao T,Sabirzhanov B,Li H,Liu S,Wu LJ,Wu J
48-0451-82 was used in Flow Cytometry to show, using a contusion-induced traumatic spinal cord injury mouse model, tissue acidification is mediated by Hv1 which, in turn, contributes to functional outcome and neuronal death in the gray matter.
Fri Jan 01 00:00:00 EST 2021
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.
The Journal of experimental medicine
Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A
48-0451-82 was used in Flow Cytometry to show a persistent accumulation of T cells in mice and human autopsy samples for more than 1 mo after stroke.
Mon Aug 02 00:00:00 EDT 2021
Proton extrusion during oxidative burst in microglia exacerbates pathological acidosis following traumatic brain injury.
Glia
Ritzel RM,He J,Li Y,Cao T,Khan N,Shim B,Sabirzhanov B,Aubrecht T,Stoica BA,Faden AI,Wu LJ,Wu J
48-0451 was used in Flow cytometry/Cell sorting to demonstrate that intracellular pH in microglia and extracellular pH surrounding the lesion site are significantly reduced for weeks after injury.
Mon Mar 01 00:00:00 EST 2021
Antitumor efficacy of a neoantigen cancer vaccine delivered by electroporation is influenced by microbiota composition.
Oncoimmunology
Lione L,Salvatori E,Petrazzuolo A,Massacci A,Maggio R,Confroti A,Compagnone M,Aurisicchio L,Ciliberto G,Palombo F
48-0451-82 was used in Flow cytometry/Cell sorting to find that decreased microbiota diversity induced by prolonged antibiotic (ATB) treatment is associated with higher intratumor specific immune responses and consequently to a better antitumor effect induced by neoantigen cancer vaccines (NCVs) delivered by DNA-EP.
Tue Mar 23 00:00:00 EDT 2021
Early activation of the cardiac CX3CL1/CX3CR1 axis delays β-adrenergic-induced heart failure.
Scientific reports
Flamant M,Mougenot N,Balse E,Le Fèvre L,Atassi F,Gautier EL,Le Goff W,Keck M,Nadaud S,Combadière C,Boissonnas A,Pavoine C
48-0451-82 was used in Flow Cytometry to characterize macrophages (Mφ) in hearts early infused with isoproterenol as compared to control and failing hearts and evaluate the role of upregulated CX3CL1 in cardiac remodeling.
Thu Sep 09 00:00:00 EDT 2021
Reticulon-1C Involvement in Muscle Regeneration.
Metabolites
Rossin F,Avitabile E,Catarinella G,Fornetti E,Testa S,Oliverio S,Gargioli C,Cannata S,Latella L,Di Sano F
48-0451-82 was used in Flow cytometry/Cell sorting to suggest that changes in muscle metabolism such as mitochondrial dysfunction and dysregulation of intracellular Ca2+ homeostasis are implicated in many adverse conditions affecting skeletal muscle.
Wed Dec 08 00:00:00 EST 2021
Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40.
Nature communications
Yang F,He Z,Duan H,Zhang D,Li J,Yang H,Dorsey JF,Zou W,Nabavizadeh SA,Bagley SJ,Abdullah K,Brem S,Zhang L,Xu X,Byrne KT,Vonderheide RH,Gong Y,Fan Y
48-0451-82 was used in Flow Cytometry to investigate if an antibody cocktail-based immunotherapy that combines checkpoint blockade with dual-targeting of IL-6 and CD40 may offer exciting opportunities for glioblastoma and other solid tumors.
Tue Jun 08 00:00:00 EDT 2021
Heterogeneity of murine periosteum progenitors involved in fracture healing.
eLife
Matthews BG,Novak S,Sbrana FV,Funnell JL,Cao Y,Buckels EJ,Grcevic D,Kalajzic I
48-0451-82 was used in Flow Cytometry to demonstrate that the periosteum is highly enriched with skeletal progenitor cells, and there is heterogeneity in the populations of cells that contribute to mature lineages during periosteal fracture healing.
Tue Feb 09 00:00:00 EST 2021
Effects of Obesity-Associated Chronic Inflammation on Peripheral Blood Immunophenotype Are Not Mediated by TNF in Female C57BL/6J Mice.
ImmunoHorizons
Breznik JA,Foley KP,Maddiboina D,Schertzer JD,Sloboda DM,Bowdish DME
48-0451-82 was used in Flow Cytometry to characterize how TNF alters circulating cellular immunity in female mice with diet-induced obesity.
Fri Jun 04 00:00:00 EDT 2021
Dissociation of microdissected mouse brain tissue for artifact free single-cell RNA sequencing.
STAR protocols
Liu L,Besson-Girard S,Ji H,Gehring K,Bulut B,Kaya T,Usifo F,Simons M,Gokce O
48-0451-82 was used in Flow Cytometry to describe an enzymatic dissociation method for mouse brain that prevents dissociation artifacts and lowers technical variations with standardized steps.
Fri Jun 18 00:00:00 EDT 2021
Activation of skeletal muscle-resident glial cells upon nerve injury.
JCI insight
Proietti D,Giordani L,De Bardi M,D'Ercole C,Lozanoska-Ochser B,Amadio S,Volonté C,Marinelli S,Muchir A,Bouché M,Borsellino G,Sacco A,Puri PL,Madaro L
48-0451-82 was used in Flow cytometry/Cell sorting to report on the identification of Itga7-expressing muscle-resident glial cells activated by loss of neuromuscular junction (NMJ) integrity.
Thu Apr 08 00:00:00 EDT 2021
Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas.
Science advances
Heino S,Fang S,Lähde M,Högström J,Nassiri S,Campbell A,Flanagan D,Raven A,Hodder M,Nasreddin N,Xue HH,Delorenzi M,Leedham S,Petrova TV,Sansom O,Alitalo K
48-0451-82 was used in Flow Cytometry to show that Lef1 is expressed exclusively in Apc-mutant, Wnt ligand-independent tumors, but not in ligand-dependent, serrated tumors.
Fri Nov 19 00:00:00 EST 2021
Optimizing AAV2/6 microglial targeting identified enhanced efficiency in the photoreceptor degenerative environment.
Molecular therapy. Methods & clinical development
Maes ME,Wögenstein GM,Colombo G,Casado-Polanco R,Siegert S
48-0451-82 was used in Immunocytochemistry-immunoflourescence to provide a foundation for future studies optimizing AAV-mediated microglia transduction and highlight that environmental conditions influence microglial transduction efficiency.
Fri Dec 10 00:00:00 EST 2021
The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition.
Cell reports
Azzoni E,Frontera V,Anselmi G,Rode C,James C,Deltcheva EM,Demian AS,Brown J,Barone C,Patelli A,Harman JR,Nicholls M,Conway SJ,Morrissey E,Jacobsen SEW,Sparrow DB,Harris AL,Enver T,de Bruijn MFTR
48-0451-82 was used in Immunocytochemistry-immunoflourescence to investigate how and when the onset of circulation affects Hematopoietic stem cells emergence.
Tue Dec 14 00:00:00 EST 2021
Multi-color Flow Cytometry for Comprehensive Analysis of the Tumor Immune Infiltrate in a Murine Model of Breast Cancer.
Bio-protocol
Almeida AS,Fein MR,Egeblad M
48-0451-82 was used in Flow cytometry/Cell sorting to describe a detailed procedure for preparing a single-cell suspension from mammary tumors of the mouse mammary tumor virus-polyoma middle T (MMTV-PyMT) and analyzing these cells by multi-color flow cytometry.
Sat Jun 05 00:00:00 EDT 2021
Spinal cord injury alters microRNA and CD81+ exosome levels in plasma extracellular nanoparticles with neuroinflammatory potential.
Brain, behavior, and immunity
Khan NZ,Cao T,He J,Ritzel RM,Li Y,Henry RJ,Colson C,Stoica BA,Faden AI,Wu J
48-0451-82 was used in Flow cytometry/Cell sorting to provide the first detailed characterization of plasma EV dynamics after SCI and suggest that plasma EVs may be involved in posttraumatic brain inflammation.
Mon Feb 01 00:00:00 EST 2021
Skeletal Muscle Subpopulation Rearrangements upon Rhabdomyosarcoma Development through Single-Cell Mass Cytometry.
Journal of clinical medicine
Petrilli LL,Riccio F,Giuliani G,Palma A,Gargioli C,Vumbaca S,Faron M,Palmieri G,Pasquini L,Sacco F,Cesareni G,Castagnoli L,Fuoco C
48-0451 was used in Flow cytometry/Cell sorting to monitoring of the changes occurring in the mononuclear cell composition of skeletal muscle tissue during embryonal rhabdomyosarcoma development using mass spectrometry.
Wed Feb 17 00:00:00 EST 2021
Determining the effect of aging, recovery time, and post-stroke memantine treatment on delayed thalamic gliosis after cortical infarct.
Scientific reports
Kim GS,Stephenson JM,Al Mamun A,Wu T,Goss MG,Min JW,Li J,Liu F,Marrelli SP
48-0451-82 was used in Flow Cytometry to expand our understanding of gliosis in the thalamus following cortical stroke and demonstrate age-dependency of this secondary injury.
Tue Jun 15 00:00:00 EDT 2021
Exogenous inter-α inhibitor proteins prevent cell death and improve ischemic stroke outcomes in mice.
The Journal of clinical investigation
McCullough LD,Roy-O'Reilly M,Lai YJ,Patrizz A,Xu Y,Lee J,Holmes A,Kraushaar DC,Chauhan A,Sansing LH,Stonestreet BS,Zhu L,Kofler J,Lim YP,Venna VR
48-0451-82 was used in flow cytometry to indicate that IAIP is a potential therapeutic candidate for the treatment of ischemic stroke.
Wed Sep 01 00:00:00 EDT 2021
Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells.
Cell
Shwartz Y,Gonzalez-Celeiro M,Chen CL,Pasolli HA,Sheu SH,Fan SM,Shamsi F,Assaad S,Lin ET,Zhang B,Tsai PC,He M,Tseng YH,Lin SJ,Hsu YC
48-0451-82 was used in Flow Cytometry to demonstrate sympathetic nerves can modulate stem cells through synapse-like connections and neurotransmitters to couple tissue production with demands.
Thu Aug 06 00:00:00 EDT 2020
Development of a near infrared protein nanoprobe targeting Thomsen-Friedenreich antigen for intraoperative detection of submillimeter nodules in an ovarian peritoneal carcinomatosis mouse model.
Biomaterials
Coustets M,Ladurantie C,Bellard E,Prat M,Rols MP,Ecochard V,Ferron G,Chabot S,Golzio M,Paquereau L
48-0451 was used in Immunohistochemistry to develop a recombinant lectin as a nanoprobe for the microscopic detection of nodules in the peritoneal cavity of tumor-bearing mice.
Fri May 01 00:00:00 EDT 2020
The aging skin microenvironment dictates stem cell behavior.
Proceedings of the National Academy of Sciences of the United States of America
Ge Y,Miao Y,Gur-Cohen S,Gomez N,Yang H,Nikolova M,Polak L,Hu Y,Verma A,Elemento O,Krueger JG,Fuchs E
48-0451 was used in Flow cytometry/Cell sorting to highlight the importance of SC:niche interactions and favor a model where youthfulness of the niche microenvironment plays a dominant role in dictating the properties of its SCs and tissue health and fitness.
Tue Mar 10 00:00:00 EDT 2020
HDAC inhibitors tune miRNAs in extracellular vesicles of dystrophic muscle-resident mesenchymal cells.
EMBO reports
Sandonà M,Consalvi S,Tucciarone L,De Bardi M,Scimeca M,Angelini DF,Buffa V,D'Amico A,Bertini ES,Cazzaniga S,Bettica P,Bouché M,Bongiovanni A,Puri PL,Saccone V
48-0451-82 was used in Flow Cytometry to show that extracellular vesicles (EVs) released by mesenchymal cells (i.e., fibro-adipogenic progenitors-FAPs) mediate microRNA (miR) transfer to muscle stem cells (MuSCs) and that exposure of dystrophic FAPs to HDAC inhibitors (HDACis) increases the intra-EV levels of a subset of miRs, which cooperatively target biological processes of therapeutic interest, including regeneration, fibrosis, and inflammation.
Thu Sep 03 00:00:00 EDT 2020
Single cell and tissue-transcriptomic analysis of murine bladders reveals age- and TNFα-dependent but microbiota-independent tertiary lymphoid tissue formation.
Mucosal immunology
Ligon MM,Wang C,DeJong EN,Schulz C,Bowdish DME,Mysorekar IU
48-0451 was used in Flow cytometry/Cell sorting to indicate that chronic, age-associated inflammation underlies a fundamental alteration to the bladder and establishes a resource for further investigation of the bladder immune system in homeostasis, aging, and disease.
Sun Nov 01 00:00:00 EDT 2020
Mast Cells Occupy Stable Clonal Territories in Adult Steady-State Skin.
The Journal of investigative dermatology
Weitzmann A,Naumann R,Dudeck A,Zerjatke T,Gerbaulet A,Roers A
48-0451 was used in Flow cytometry/Cell sorting to conclude that during a limited window early in development, definitive MC precursors efficiently enter the skin, expand, and self-maintain, occupying stable territories.
Tue Dec 01 00:00:00 EST 2020
Life-span Extension Drug Interventions Affect Adipose Tissue Inflammation in Aging.
The journals of gerontology. Series A, Biological sciences and medical sciences
Mau T,O'Brien M,Ghosh AK,Miller RA,Yung R
48-0451 was used in Flow cytometry/Cell sorting to study the effects of three drugs identified in the Interventions Testing Program on inflammation in gonadal white adipose tissue of HET3 mice.
Wed Jan 01 00:00:00 EST 2020
Mycobacterial Trehalose 6,6'-Dimycolate-Induced M1-Type Inflammation.
The American journal of pathology
Nguyen TKT,d'Aigle J,Chinea L,Niaz Z,Hunter RL,Hwang SA,Actor JK
48-0451 was used in Flow cytometry/Cell sorting to investigate the role of trehalose 6,6'-dimycolate (TDM) in the early macrophages response during initiation of granulomas of primary pathology.
Sat Feb 01 00:00:00 EST 2020
Neuroprotective and neuro-rehabilitative effects of acute purinergic receptor P2X4 (P2X4R) blockade after ischemic stroke.
Experimental neurology
Srivastava P,Cronin CG,Scranton VL,Jacobson KA,Liang BT,Verma R
48-0451-82 was used in Flow Cytometry to suggest that acute P2X4R inhibition protects against ischemic injury both at acute and chronic time-points after stroke.
Wed Jul 01 00:00:00 EDT 2020
IL-13 Ameliorates Neuroinflammation and Promotes Functional Recovery after Traumatic Brain Injury.
Journal of immunology (Baltimore, Md. : 1950)
Miao W,Zhao Y,Huang Y,Chen D,Luo C,Su W,Gao Y
48-0451 was used in Flow cytometry/Cell sorting to demonstrate that IL-13 treatment improved neurologic outcomes after Traumatic Brain Injury through adjusting microglia/macrophage phenotypes and inhibiting inflammatory responses.
Sun Mar 15 00:00:00 EDT 2020
Adipose tissue dendritic cell signals are required to maintain T cell homeostasis and obesity-induced expansion.
Molecular and cellular endocrinology
Porsche CE,Delproposto JB,Patrick E,Zamarron BF,Lumeng CN
48-0451 was used in Flow cytometry/Cell sorting to investigate the contribution of dendritic cells to adipose tissue derived chronic inflammation as professional antigen presenting cells in adipose issue.
Sun Apr 05 00:00:00 EDT 2020
Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction.
eLife
Alonso-Herranz L,Sahún-Español Á,Paredes A,Gonzalo P,Gkontra P,Núñez V,Clemente C,Cedenilla M,Villalba-Orero M,Inserte J,García-Dorado D,Arroyo AG,Ricote M
48-0451-82 was used in Immunocytochemistry to indicate the contribution of EndMT to cardiac fibrosis and adverse remodeling post-MI and identify Mφ MT1-MMP as a key regulator of this process.
Fri Oct 16 00:00:00 EDT 2020
Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP/TGFβ1 after myocardial infarction.
eLife
Alonso-Herranz L,Sahún-Español Á,Paredes A,Gonzalo P,Gkontra P,Núñez V,Clemente C,Cedenilla M,Villalba-Orero M,Inserte J,García-Dorado D,Arroyo AG,Ricote M
48-0451-82 was used in Immunocytochemistry to indicate the contribution of EndMT to cardiac fibrosis and adverse remodeling post-MI and identify Mφ MT1-MMP as a key regulator of this process.
Fri Oct 16 00:00:00 EDT 2020
Integrated Single-Cell Transcriptomics and Chromatin Accessibility Analysis Reveals Regulators of Mammary Epithelial Cell Identity.
Cell reports
Pervolarakis N,Nguyen QH,Williams J,Gong Y,Gutierrez G,Sun P,Jhutty D,Zheng GXY,Nemec CM,Dai X,Watanabe K,Kessenbrock K
48-0451-82 was used in Flow Cytometry to provide a resource to reveal cis/trans-regulatory elements associated with MEC identity and differentiation that will serve as a reference to determine how the chromatin accessibility landscape changes during breast cancer.
Tue Oct 20 00:00:00 EDT 2020
SHP-1 Regulates Antigen Cross-Presentation and Is Exploited by Leishmania to Evade Immunity.
Cell reports
Khouili SC,Cook ECL,Hernández-García E,Martínez-López M,Conde-Garrosa R,Iborra S
48-0451 was used in Flow cytometry/Cell sorting to demonstrate that SHP-1 inhibition improves CD11c+ cell-based vaccination against the parasite.
Tue Dec 01 00:00:00 EST 2020
Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice.
Nature communications
Wang S,Cao S,Arhatte M,Li D,Shi Y,Kurz S,Hu J,Wang L,Shao J,Atzberger A,Wang Z,Wang C,Zang W,Fleming I,Wettschureck N,Honoré E,Offermanns S
48-0451 was used in Flow cytometry/Cell sorting to study the mechanosensitive cationic channel Piezo1 and its mediation of diet-induced adipogenesis.
Fri May 08 00:00:00 EDT 2020
Potential caveats of putative microglia-specific markers for assessment of age-related cerebrovascular neuroinflammation.
Journal of neuroinflammation
Honarpisheh P,Lee J,Banerjee A,Blasco-Conesa MP,Honarpisheh P,d'Aigle J,Mamun AA,Ritzel RM,Chauhan A,Ganesh BP,McCullough LD
48-0451 was used in Flow cytometry/Cell sorting to examine changes in expression levels of these putative microglia markers in in vivo animal models of stroke, cerebral amyloid angiopathy (CAA), and aging as well as in an ex vivo LPS-induced inflammation model.
Tue Dec 01 00:00:00 EST 2020
Genetic deletion of the Rho GEF Net1 impairs mouse macrophage motility and actin cytoskeletal organization.
Small GTPases
Zuo Y,d'Aigle J,Chauhan A,Frost JA
48-0451 was used in Flow cytometry/Cell sorting to demonstrate that Net1 is an important regulator of RhoA signaling and motility in mouse macrophages in vitro, but that its function may be dispensable for macrophage recruitment to inflammatory sites in vivo.
Wed Jul 01 00:00:00 EDT 2020
Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis.
Cell reports
Leavitt T,Hu MS,Borrelli MR,Januszyk M,Garcia JT,Ransom RC,Mascharak S,desJardins-Park HE,Litzenburger UM,Walmsley GG,Marshall CD,Moore AL,Duoto B,Adem S,Foster DS,Salhotra A,Shen AH,Griffin M,Shen EZ,Barnes LA,Zielins ER,Maan ZN,Wei Y,Chan CKF,Wan DC,Lorenz HP,Chang HY,Gurtner GC,Longaker MT
48-0451-82 was used in Flow Cytometry to identify and characterise a fibroblast subpopulation in the mouse ventral dermis with intrinsic scar-forming potential.
Tue Nov 10 00:00:00 EST 2020
Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement.
eLife
Kalinski AL,Yoon C,Huffman LD,Duncker PC,Kohen R,Passino R,Hafner H,Johnson C,Kawaguchi R,Carbajal KS,Jara JS,Hollis E,Geschwind DH,Segal BM,Giger RJ
48-0451 was used in Flow cytometry/Cell sorting to analyse the inflammatory response to sciatic nerve injury.
Wed Dec 02 00:00:00 EST 2020
Resident macrophages acquire innate immune memory in staphylococcal skin infection.
eLife
Feuerstein R,Forde AJ,Lohrmann F,Kolter J,Ramirez NJ,Zimmermann J,Gomez de Agüero M,Henneke P
48-0451 was used in Flow cytometry/Cell sorting to show that resident dermal Mφ are programmed locally, independently of bone marrow-derived monocytes during staphylococcal skin infection leading to transiently increased resistance against a second infection.
Wed Jul 08 00:00:00 EDT 2020
Skeletal muscle healing by M1-like macrophages produced by transient expression of exogenous GM-CSF.
Stem cell research & therapy
Martins L,Gallo CC,Honda TSB,Alves PT,Stilhano RS,Rosa DS,Koh TJ,Han SW
48-0451 was used in Flow cytometry/Cell sorting to study the show if increasing the number of M1-like macrophages immediately after traumatic muscle injury can promotes muscle recovery with less fibrosis, and if this can be achieved by the transient expression of GM-CSF.
Fri Nov 06 00:00:00 EST 2020
Increased sensitivity of BCR-ABL-induced B-ALL to imatinib by releasing leukemia B cell differentiation blockage.
International journal of clinical and experimental pathology
Wang Z,Li Y,Lu X,Yuan J,Qiu Q,Pan C
48-0451 was used in Flow cytometry/Cell sorting to investigate whether it was possible to promote pro/pre-B cell maturation beyond this phase and make them sensitive to imatinib treatment by overexpressing immunoregulatory tyrosine activation motif (ITAM) with BCR-ABL in a Ph+ B-ALL mouse model.
Wed Dec 09 00:00:00 EST 2020
Delayed microglial depletion after spinal cord injury reduces chronic inflammation and neurodegeneration in the brain and improves neurological recovery in male mice.
Theranostics
Li Y,Ritzel RM,Khan N,Cao T,He J,Lei Z,Matyas JJ,Sabirzhanov B,Liu S,Li H,Stoica BA,Loane DJ,Faden AI,Wu J
48-0451 was used in Flow cytometry/Cell sorting to show deletion of microglia can improve recovery of cognition, depressive-like behavior, and motor function by reducing neuroinflammation in the injured spinal cord and brain.
Tue Jun 01 00:00:00 EDT 2021
EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity.
eLife
Frye M,Stritt S,Ortsäter H,Hernandez Vasquez M,Kaakinen M,Vicente A,Wiseman J,Eklund L,Martínez-Torrecuadrada JL,Vestweber D,Mäkinen T
48-0451 was used in Flow cytometry/Cell sorting to identify the transmembrane ligand EphrinB2 and its receptor EphB4 as critical homeostatic regulators of collecting lymphatic vessel integrity.
Tue Sep 08 00:00:00 EDT 2020
Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.
JCI insight
Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A
48-0451 was used in Flow cytometry/Cell sorting to study can serve as a foundation for trials testing immunotherapeutic approaches in patients with ovarian GCT.
Thu Aug 20 00:00:00 EDT 2020
Elucidating the fundamental fibrotic processes driving abdominal adhesion formation.
Nature communications
Foster DS,Marshall CD,Gulati GS,Chinta MS,Nguyen A,Salhotra A,Jones RE,Burcham A,Lerbs T,Cui L,King ME,Titan AL,Ransom RC,Manjunath A,Hu MS,Blackshear CP,Mascharak S,Moore AL,Norton JA,Kin CJ,Shelton AA,Januszyk M,Gurtner GC,Wernig G,Longaker MT
48-0451 was used in Flow cytometry/Cell sorting to present a systematic analysis of mouse and human adhesion tissues.
Thu Aug 13 00:00:00 EDT 2020
Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.
Communications biology
Waaler J,Mygland L,Tveita A,Strand MF,Solberg NT,Olsen PA,Aizenshtadt A,Fauskanger M,Lund K,Brinch SA,Lycke M,Dybing E,Nygaard V,Bøe SL,Heintz KM,Hovig E,Hammarström C,Corthay A,Krauss S
48-0451 was used in Flow cytometry/Cell sorting to show that a specific small-molecule tankyrase inhibitor, G007-LK, decreases WNT/β-catenin and YAP signaling in the syngeneic murine B16-F10 and Clone M-3 melanoma models and sensitizes the tumors to anti-PD-1 immune checkpoint therapy.
Fri Apr 24 00:00:00 EDT 2020
Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant.
NPJ vaccines
Van Den Eeckhout B,Van Hoecke L,Burg E,Van Lint S,Peelman F,Kley N,Uzé G,Saelens X,Tavernier J,Gerlo S
48-0451 was used in Flow cytometry/Cell sorting to demonstrate safe inclusion of IL-1β as an adjuvant in vaccination strategies, leading to full protection of mice against a high influenza virus challenge dose by raising potent T cell responses.
Tue Sep 19 00:00:00 EDT 2023
Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity.
Cell
Gauthier L,Morel A,Anceriz N,Rossi B,Blanchard-Alvarez A,Grondin G,Trichard S,Cesari C,Sapet M,Bosco F,Rispaud-Blanc H,Guillot F,Cornen S,Roussel A,Amigues B,Habif G,Caraguel F,Arrufat S,Remark R,Romagné F,Morel Y,Narni-Mancinelli E,Vivier E
48-0451 was used in Flow cytometry/Cell sorting to study a new generation of anti-cancer trifunctional natural killer cell engagers (NKCEs) that target activating receptors NKp46 and CD16.
Thu Jun 13 00:00:00 EDT 2019
Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity.
Immunity
Martínez-López M,Iborra S,Conde-Garrosa R,Mastrangelo A,Danne C,Mann ER,Reid DM,Gaboriau-Routhiau V,Chaparro M,Lorenzo MP,Minnerup L,Saz-Leal P,Slack E,Kemp B,Gisbert JP,Dzionek A,Robinson MJ,Rupérez FJ,Cerf-Bensussan N,Brown GD,Bernardo D,LeibundGut-Landmann S,Sancho D
48-0451-82 was used in Flow Cytometry to conclude that sensing of commensals by Mincle and Syk signaling in CD11c+ cells reinforces intestinal immune barrier and promotes host-microbiota mutualism, preventing systemic inflammation.
Tue Feb 19 00:00:00 EST 2019
The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability.
Cancer cell
Huang Y,Mouttet B,Warnatz HJ,Risch T,Rietmann F,Frommelt F,Ngo QA,Dobay MP,Marovca B,Jenni S,Tsai YC,Matzk S,Amstislavskiy V,Schrappe M,Stanulla M,Gstaiger M,Bornhauser B,Yaspo ML,Bourquin JP
48-0451-82 was used in Flow cytometry/Cell sorting to decipher the regulome of endogenous TCF3-HLF and dissect its essential transcriptional components and targets by functional genomics.
Mon Dec 09 00:00:00 EST 2019
cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
The Journal of clinical investigation
Wang Z,Chen J,Hu J,Zhang H,Xu F,He W,Wang X,Li M,Lu W,Zeng G,Zhou P,Huang P,Chen S,Li W,Xia LP,Xia X
48-0451 was used in Flow cytometry/Cell sorting to show that teniposide could trigger tumor immunogenicity and enable a potential chemoimmunotherapeutic approach to potentiating the therapeutic efficacy of anti-PD1 immunotherapy.
Tue Aug 13 00:00:00 EDT 2019
Engulfment of mast cell secretory granules on skin inflammation boosts dendritic cell migration and priming efficiency.
The Journal of allergy and clinical immunology
Dudeck J,Froebel J,Kotrba J,Lehmann CHK,Dudziak D,Speier S,Nedospasov SA,Schraven B,Dudeck A
48-0451 was used in Flow cytometry/Cell sorting to show peripheral mast cells can modify dendritic cell functionality to influence lymphoid tissue-borne adaptive immunity.
Wed May 01 00:00:00 EDT 2019
Myeloid cell IRF4 signaling protects neonatal brains from hypoxic ischemic encephalopathy.
Neurochemistry international
Al Mamun A,Yu H,Mirza MA,Romana S,McCullough LD,Liu F
48-0451 was used in Flow cytometry/Cell sorting to demonstrate that IRF4 is a potent regulator of the inflammatory response after in hypoxic ischemic encephalopathy (HIE).
Mon Jul 01 00:00:00 EDT 2019
In Situ Modification of Tissue Stem and Progenitor Cell Genomes.
Cell reports
Goldstein JM,Tabebordbar M,Zhu K,Wang LD,Messemer KA,Peacker B,Ashrafi Kakhki S,Gonzalez-Celeiro M,Shwartz Y,Cheng JKW,Xiao R,Barungi T,Albright C,Hsu YC,Vandenberghe LH,Wagers AJ
48-0451 was used in Flow cytometry/Cell sorting to demonstrate in vivo transduction of endogenous tissue stem cells in the muscle, blood, and skin by systemic or local administration of adeno-associated viruses (AAVs) encoding genome-modifying enzymes.
Tue Apr 23 00:00:00 EDT 2019
STAT6/Arg1 promotes microglia/macrophage efferocytosis and inflammation resolution in stroke mice.
JCI insight
Cai W,Dai X,Chen J,Zhao J,Xu M,Zhang L,Yang B,Zhang W,Rocha M,Nakao T,Kofler J,Shi Y,Stetler RA,Hu X,Chen J
48-0451 was used in Flow Cytometry to suggest that efferocytosis via STAT6/Arg1 modulates microglia/macrophage phenotype, accelerates inflammation resolution, and improves stroke outcomes.
Thu Oct 17 00:00:00 EDT 2019
Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis.
Cell metabolism
Choi WM,Kim HH,Kim MH,Cinar R,Yi HS,Eun HS,Kim SH,Choi YJ,Lee YS,Kim SY,Seo W,Lee JH,Shim YR,Kim YE,Yang K,Ryu T,Hwang JH,Lee CH,Choi HS,Gao B,Kim W,Kim SK,Kunos G,Jeong WI
48-0451-82 was used in Flow cytometry/Cell sorting to investigate hepatocyte cannabinoid receptor-1 in alcoholic liver disease and lipogenesis.
Tue Nov 05 00:00:00 EST 2019
Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers.
Nature communications
Zhang F,Parayath NN,Ene CI,Stephan SB,Koehne AL,Coon ME,Holland EC,Stephan MT
Tue Sep 03 00:00:00 EDT 2019
Sox17 is required for endothelial regeneration following inflammation-induced vascular injury.
Nature communications
Liu M,Zhang L,Marsboom G,Jambusaria A,Xiong S,Toth PT,Benevolenskaya EV,Rehman J,Malik AB
48-0451-82 was used in Flow Cytometry to study the mechanism of endothelial regeneration.
Thu May 09 00:00:00 EDT 2019
Quiescent Tissue Stem Cells Evade Immune Surveillance.
Immunity
Agudo J,Park ES,Rose SA,Alibo E,Sweeney R,Dhainaut M,Kobayashi KS,Sachidanandam R,Baccarini A,Merad M,Brown BD
48-0451 was used in Flow cytometry/Cell sorting to identify a link between stem cell quiescence, antigen presentation, and immune evasion.
Tue Feb 20 00:00:00 EST 2018
Aging alters the immunological response to ischemic stroke.
Acta neuropathologica
Ritzel RM,Lai YJ,Crapser JD,Patel AR,Schrecengost A,Grenier JM,Mancini NS,Patrizz A,Jellison ER,Morales-Scheihing D,Venna VR,Kofler JK,Liu F,Verma R,McCullough LD
48-0451 was used in Flow cytometry/Cell sorting to study the marked differences in the composition of circulating and infiltrating leukocytes recruited to the ischaemic brain of old male mice after stroke compared to young male mice.
Sun Jul 01 00:00:00 EDT 2018
High MUC2 Mucin Expression and Misfolding Induce Cellular Stress, Reactive Oxygen Production, and Apoptosis in Goblet Cells.
The American journal of pathology
Tawiah A,Cornick S,Moreau F,Gorman H,Kumar M,Tiwari S,Chadee K
48-0451 was used in Flow cytometry/Cell sorting to study the role of MUC2 in the depletion of goblet cells and mucus layer in inflammatory bowel disease.
Fri Jun 01 00:00:00 EDT 2018
Inflammatory Responses are Sex Specific in Chronic Hypoxic-Ischemic Encephalopathy.
Cell transplantation
Al Mamun A,Yu H,Romana S,Liu F
48-0451 was used in Flow cytometry/Cell sorting to investigate the sex difference in neonatal hypoxic-ischaemic encephalopathy outcomes and inflammatory response in the chronic stage.
Sat Sep 01 00:00:00 EDT 2018
Regulated Release of Cryptococcal Polysaccharide Drives Virulence and Suppresses Immune Cell Infiltration into the Central Nervous System.
Infection and immunity
Denham ST,Verma S,Reynolds RC,Worne CL,Daugherty JM,Lane TE,Brown JCS
48-0451 was used in Flow cytometry/Cell sorting to show that exo-glucuronoxylomannan (exo-GXM) performs a different role from capsule GXM during infection, altering cell size and suppressing inflammation.
Thu Mar 01 00:00:00 EST 2018
Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1I249/M280 Variant.
Frontiers in cellular neuroscience
Cardona SM,Kim SV,Church KA,Torres VO,Cleary IA,Mendiola AS,Saville SP,Watowich SS,Parker-Thornburg J,Soto-Ospina A,Araque P,Ransohoff RM,Cardona AE
Thu Oct 01 00:00:00 EDT 2020
An IFNγ/CXCL2 regulatory pathway determines lesion localization during EAE.
Journal of neuroinflammation
Stoolman JS,Duncker PC,Huber AK,Giles DA,Washnock-Schmid JM,Soulika AM,Segal BM
48-0451 was used in Flow cytometry/Cell sorting to show a new mechanism by which IFNγ and CXCL2 interact to direct regional recruitment of leukocytes in the central nervous system.
Mon Jul 16 00:00:00 EDT 2018
A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.
eLife
Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY
48-0451 was used in Flow cytometry/Cell sorting to study the activation of Bcl11b, which controls T-cell fate commitment.
Tue Nov 20 00:00:00 EST 2018
Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer.
Cell reports
Barros-Silva JD,Linn DE,Steiner I,Guo G,Ali A,Pakula H,Ashton G,Peset I,Brown M,Clarke NW,Bronson RT,Yuan GC,Orkin SH,Li Z,Baena E
48-0451 was used in Flow cytometry/Cell sorting to analyse the molecular heterogeneity in basal and luminal prostate compartments.
Tue Dec 18 00:00:00 EST 2018
A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy.
Nature communications
Lee RS,Waters AP,Brewer JM
48-0451 was used in Flow cytometry/Cell sorting to enumerate Plasmodium infected erythropoietic precursor cells using an in vivo rodent model of Plasmodium berghei.
Fri Apr 27 00:00:00 EDT 2018
Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program.
Nature communications
Frye M,Taddei A,Dierkes C,Martinez-Corral I,Fielden M,Ortsäter H,Kazenwadel J,Calado DP,Ostergaard P,Salminen M,He L,Harvey NL,Kiefer F,Mäkinen T
48-0451 was used in Flow cytometry/Cell sorting to study whether extracellular matrix stiffness impacts lymphatic vascular development.
Tue Apr 17 00:00:00 EDT 2018
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
48-0451 was used in Flow cytometry/Cell sorting to identify a regulatory subpopulation of innate lymphoid cells that exists in the gut, and harbour a unique gene identity.
Thu Sep 21 00:00:00 EDT 2017
Stem Cell Lineage Infidelity Drives Wound Repair and Cancer.
Cell
Ge Y,Gomez NC,Adam RC,Nikolova M,Yang H,Verma A,Lu CP,Polak L,Yuan S,Elemento O,Fuchs E
48-0451 was used in Flow cytometry/Cell sorting to investigate the homeostatic mechanisms of tissue regeneration and wound repair by tissue stem cells in the skin, that can be hijacked by cancer cells.
Thu May 04 00:00:00 EDT 2017
A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer.
Cancer cell
Mello SS,Valente LJ,Raj N,Seoane JA,Flowers BM,McClendon J,Bieging-Rolett KT,Lee J,Ivanochko D,Kozak MM,Chang DT,Longacre TA,Koong AC,Arrowsmith CH,Kim SK,Vogel H,Wood LD,Hruban RH,Curtis C,Attardi LD
48-0451 was used in Flow cytometry/Cell sorting to analyse pancreatic cancer development in mice expressing p53 transcriptional activation domain mutants.
Mon Oct 09 00:00:00 EDT 2017
Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction.
Cell host & microbe
Thevaranjan N,Puchta A,Schulz C,Naidoo A,Szamosi JC,Verschoor CP,Loukov D,Schenck LP,Jury J,Foley KP,Schertzer JD,Larché MJ,Davidson DJ,Verdú EF,Surette MG,Bowdish DME
48-0451 was used in Flow cytometry/Cell sorting to study the potential of changes to the microbiota as a strategy for reducing age-associated inflammation and the accompanying morbidity.
Wed Apr 12 00:00:00 EDT 2017
Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes.
The Journal of clinical investigation
Chang SK,Kohlgruber AC,Mizoguchi F,Michelet X,Wolf BJ,Wei K,Lee PY,Lynch L,Duquette D,Ceperuelo-Mallafré V,Banks AS,Brenner MB
48-0451 was used in Flow cytometry/Cell sorting to suggest that stromal fibroblasts expressing cadherin-11 regulate adipose tissue inflammation.
Fri Sep 01 00:00:00 EDT 2017
Eosinophils are required to suppress Th2 responses in Peyer's patches during intestinal infection by nematodes.
Mucosal immunology
Strandmark J,Steinfelder S,Berek C,Kühl AA,Rausch S,Hartmann S
48-0451 was used in Flow cytometry/Cell sorting to study whether eosinophils affect the local T-cell and antibody response in the gut-associated lymphoid tissue during enteric infections.
Mon May 01 00:00:00 EDT 2017
Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity.
Development (Cambridge, England)
Wang Y,Jin Y,Mäe MA,Zhang Y,Ortsäter H,Betsholtz C,Mäkinen T,Jakobsson L
48-0451 was used in Flow cytometry/Cell sorting to demonstrate that platelet-derived growth factor B regulates lymphatic smooth muscle cell recruitment in multiple vascular beds.
Sun Oct 01 00:00:00 EDT 2017
Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis.
mAbs
Vicari AP,Schoepfer AM,Meresse B,Goffin L,Léger O,Josserand S,Guégan N,Yousefi S,Straumann A,Cerf-Bensussan N,Simon HU,Chvatchko Y
48-0451 was used in Flow cytometry/Cell sorting to identify and characterise a humanised antibody against IL-15.
Wed Nov 20 00:00:00 EST 2019
Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.
Journal of immunology (Baltimore, Md. : 1950)
Dolina JS,Cechova S,Rudy CK,Sung SJ,Tang WW,Lee J,Hahn YS,Le TH
48-0451 was used in Flow cytometry/Cell sorting to identify the functional role of collectrin in the liver.
Wed Mar 15 00:00:00 EDT 2017
Herpes simplex virus-1 infects the olfactory bulb shortly following ocular infection and exhibits a long-term inflammatory profile in the form of effector and HSV-1-specific T cells.
Journal of neuroinflammation
Menendez CM,Carr DJJ
48-0451 was used in Flow cytometry/Cell sorting to characterise the capacity of Herpes simplex virus 1 to establish latency within olfactory bulb tissue and profile the local T lymphocyte response.
Fri Jun 23 00:00:00 EDT 2017
Loss of IRF2BP2 in Microglia Increases Inflammation and Functional Deficits after Focal Ischemic Brain Injury.
Frontiers in cellular neuroscience
Cruz SA,Hari A,Qin Z,Couture P,Huang H,Lagace DC,Stewart AFR,Chen HH
48-0451 was used in Flow cytometry/Cell sorting to identify that IRF2 binding protein 2 expression in macrophages/microglia is important in limiting inflammation and stroke injury, by mediating the beneficial effect of interferon beta.
Thu Mar 17 00:00:00 EDT 2022
Praja1 E3 ubiquitin ligase promotes skeletal myogenesis through degradation of EZH2 upon p38α activation.
Nature communications
Consalvi S,Brancaccio A,Dall'Agnese A,Puri PL,Palacios D
48-0451 was used in Flow cytometry/Cell sorting to determine that signal-dependent degradation of EZH2, a PRC2 subunit, is a prerequisite for satellite cell differentiation.
Mon Jan 09 00:00:00 EST 2017
Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity.
NPJ vaccines
Stephen J,Scales HE,Benson RA,Erben D,Garside P,Brewer JM
48-0451 was used in Flow cytometry/Cell sorting to show that the very early injection site reaction is characterised by inflammatory chemokine production and neutrophil recruitment.
Fri Apr 08 00:00:00 EDT 2022
Creation of an immunodeficient HLA-transgenic mouse (HUMAMICE) and functional validation of human immunity after transfer of HLA-matched human cells.
PloS one
Zeng Y,Liu B,Rubio MT,Wang X,Ojcius DM,Tang R,Durrbach A,Ru Z,Zhou Y,Lone YC
48-0451 was used in Flow cytometry/Cell sorting to generate a novel immuno-deficient mouse strain expressing human HLA molecules instead of mouse MHC molecules.
Tue Sep 05 00:00:00 EDT 2017
Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency.
Immunity
Terashima A,Okamoto K,Nakashima T,Akira S,Ikuta K,Takayanagi H
48-0451 was used in Flow cytometry/Cell sorting to study how lymphoma persists after the accelerated sepsis induced-lymphocyte apoptosis subsides.
Tue Jun 21 00:00:00 EDT 2016
Strand-specific in vivo screen of cancer-associated miRNAs unveils a role for miR-21(∗) in SCC progression.
Nature cell biology
Ge Y,Zhang L,Nikolova M,Reva B,Fuchs E
48-0451 was used in Flow cytometry/Cell sorting to identify which of the microRNAs abundantly expressed in squamous cell carcinoma are key drivers in malignant progression.
Fri Jan 01 00:00:00 EST 2016
Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation.
Nature cell biology
Welte T,Kim IS,Tian L,Gao X,Wang H,Li J,Holdman XB,Herschkowitz JI,Pond A,Xie G,Kurley S,Nguyen T,Liao L,Dobrolecki LE,Pang L,Mo Q,Edwards DP,Huang S,Xin L,Xu J,Li Y,Lewis MT,Wang T,Westbrook TF,Rosen JM,Zhang XH
48045182 was used in flow cytometry to describe the role of mTOR signalling in recruiting pro-tumorigenic myeloid-derived suppressor cells.
Wed Jun 01 00:00:00 EDT 2016
Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment.
The Journal of clinical investigation
Starobinets H,Ye J,Broz M,Barry K,Goldsmith J,Marsh T,Rostker F,Krummel M,Debnath J
48-0451 was used in Flow cytometry/Cell sorting to evaluate how autophagy inhibition impacts the antitumor immune response in immune-competent mouse models of melanoma and mammary cancer.
Thu Dec 01 00:00:00 EST 2016
Lymphatic vessels regulate immune microenvironments in human and murine melanoma.
The Journal of clinical investigation
Lund AW,Wagner M,Fankhauser M,Steinskog ES,Broggi MA,Spranger S,Gajewski TF,Alitalo K,Eikesdal HP,Wiig H,Swartz MA
48-0451 was used in Immunohistochemistry to suggest that the establishment of tumour-associated inflammation and immunity critically depends on lymphatic vessel remodelling and drainage.
Thu Sep 01 00:00:00 EDT 2016
Lymphatic vessels regulate immune microenvironments in human and murine melanoma.
The Journal of clinical investigation
Lund AW,Wagner M,Fankhauser M,Steinskog ES,Broggi MA,Spranger S,Gajewski TF,Alitalo K,Eikesdal HP,Wiig H,Swartz MA
48-0451 was used in Immunohistochemistry to suggest that the establishment of tumour-associated inflammation and immunity critically depends on lymphatic vessel remodelling and drainage.
Thu Sep 01 00:00:00 EDT 2016
Lymphatic vessels regulate immune microenvironments in human and murine melanoma.
The Journal of clinical investigation
Lund AW,Wagner M,Fankhauser M,Steinskog ES,Broggi MA,Spranger S,Gajewski TF,Alitalo K,Eikesdal HP,Wiig H,Swartz MA
48-0451 was used in Immunohistochemistry to suggest that the establishment of tumour-associated inflammation and immunity critically depends on lymphatic vessel remodelling and drainage.
Thu Sep 01 00:00:00 EDT 2016
Lymphatic vessels regulate immune microenvironments in human and murine melanoma.
The Journal of clinical investigation
Lund AW,Wagner M,Fankhauser M,Steinskog ES,Broggi MA,Spranger S,Gajewski TF,Alitalo K,Eikesdal HP,Wiig H,Swartz MA
48-0451 was used in Immunohistochemistry to suggest that the establishment of tumour-associated inflammation and immunity critically depends on lymphatic vessel remodelling and drainage.
Thu Sep 01 00:00:00 EDT 2016
Lineage tracing of cells involved in atherosclerosis.
Atherosclerosis
Albarrán-Juárez J,Kaur H,Grimm M,Offermanns S,Wettschureck N
48-0451 was used in Flow cytometry/Cell sorting to identify the origin of vascular smooth muscle cells and macrophages within atherosclerosis lesions.
Mon Aug 01 00:00:00 EDT 2016
Depletion of regulatory T cells leads to an exacerbation of delayed-type hypersensitivity arthritis in C57BL/6 mice that can be counteracted by IL-17 blockade.
Disease models & mechanisms
Atkinson SM,Hoffmann U,Hamann A,Bach E,Danneskiold-Samsøe NB,Kristiansen K,Serikawa K,Fox B,Kruse K,Haase C,Skov S,Nansen A
48-0451 was used in Flow cytometry/Cell sorting to investigate the role of regulatory T cells in delayed-type hypersensitivity arthritis through depletion, and the rescuing effect of IL-7 in connection to regulatory T cell depletion.
Fri Apr 01 00:00:00 EDT 2016
Pdgfrb-Cre targets lymphatic endothelial cells of both venous and non-venous origins.
Genesis (New York, N.Y. : 2000)
Ulvmar MH,Martinez-Corral I,Stanczuk L,Mäkinen T
48-0451 was used in Flow cytometry/Cell sorting to show that Pdgfrb-Cre does not target YS HemEC or YS-derived erythro-myeloid progenitors.
Wed Jun 01 00:00:00 EDT 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
48-0451 was used in Flow cytometry/Cell sorting to describe a protocol to obtain mature and functional MΦ from healthy as well as disease-specific murine iPSCs.
Tue Aug 09 00:00:00 EDT 2016
SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors.
Oncotarget
Xue W,Brentville VA,Symonds P,Cook KW,Yagita H,Metheringham RL,Durrant LG
48-0451 was used in Flow cytometry/Cell sorting to investigate the anti-tumour effect of a huIgG1 antibody DNA vaccine and PD-1 blockade.
Tue Dec 13 00:00:00 EST 2016
TBP/TFIID-dependent activation of MyoD target genes in skeletal muscle cells.
eLife
Malecova B,Dall'Agnese A,Madaro L,Gatto S,Coutinho Toto P,Albini S,Ryan T,Tora L,Puri PL
48-0451 was used in Flow cytometry/Cell sorting to demonstrate that TBP2 does not replace TBP during muscle differentiation.
Thu Feb 25 00:00:00 EST 2016
Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.
Nature communications
Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B
48-0451 was used in Flow cytometry/Cell sorting to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.
Mon Nov 21 00:00:00 EST 2016
Ly6C(hi) Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis.
Cell reports
Möhle L,Mattei D,Heimesaat MM,Bereswill S,Fischer A,Alutis M,French T,Hambardzumyan D,Matzinger P,Dunay IR,Wolf SA
48-0451 was used in Flow cytometry/Cell sorting to detect that treatment of adult mice with antibiotics decreases hippocampal neurogenesis and memory retention.
Tue May 31 00:00:00 EDT 2016
Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options.
Nature genetics
Fischer U,Forster M,Rinaldi A,Risch T,Sungalee S,Warnatz HJ,Bornhauser B,Gombert M,Kratsch C,Stütz AM,Sultan M,Tchinda J,Worth CL,Amstislavskiy V,Badarinarayan N,Baruchel A,Bartram T,Basso G,Canpolat C,Cario G,Cavé H,Dakaj D,Delorenzi M,Dobay MP,Eckert C,Ellinghaus E,Eugster S,Frismantas V,Ginzel S,Haas OA,Heidenreich O,Hemmrich-Stanisak G,Hezaveh K,Höll JI,Hornhardt S,Husemann P,Kachroo P,Kratz CP,Te Kronnie G,Marovca B,Niggli F,McHardy AC,Moorman AV,Panzer-Grümayer R,Petersen BS,Raeder B,Ralser M,Rosenstiel P,Schäfer D,Schrappe M,Schreiber S,Schütte M,Stade B,Thiele R,von der Weid N,Vora A,Zaliova M,Zhang L,Zichner T,Zimmermann M,Lehrach H,Borkhardt A,Bourquin JP,Franke A,Korbel JO,Stanulla M,Yaspo ML
48-0451 was used in Flow cytometry/Cell sorting to identify distinct mutation, gene expression and drug response profiles in TCF3-HLF-positive and treatment-responsive TCF3-PBX1-positive ALL.
Tue Sep 01 00:00:00 EDT 2015
TREM2 sustains microglial expansion during aging and response to demyelination.
The Journal of clinical investigation
Poliani PL,Wang Y,Fontana E,Robinette ML,Yamanishi Y,Gilfillan S,Colonna M
48-0451 was used in Flow cytometry/Cell sorting to uncover the role played by TREM 2 in the promoting microglial expansion during aging, and microglial response to white matter damage.
Fri May 01 00:00:00 EDT 2015
Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling.
The Journal of clinical investigation
Menéndez-Gutiérrez MP,Rőszer T,Fuentes L,Núñez V,Escolano A,Redondo JM,De Clerck N,Metzger D,Valledor AF,Ricote M
48-0451 was used in Flow cytometry/Cell sorting to reveal that retinoid X receptor signalling mediates bone homeostasis.
Sun Feb 01 00:00:00 EST 2015
Brahma is required for cell cycle arrest and late muscle gene expression during skeletal myogenesis.
EMBO reports
Albini S,Coutinho Toto P,Dall'Agnese A,Malecova B,Cenciarelli C,Felsani A,Caruso M,Bultman SJ,Puri PL
48-0451 was used in Flow cytometry/Cell sorting to show that Brahma and Brg1 have distinct functions at discrete stages of muscle differentiation.
Sat Aug 01 00:00:00 EDT 2015
Inflammatory monocytes recruited to the liver within 24 hours after virus-induced inflammation resemble Kupffer cells but are functionally distinct.
Journal of virology
Movita D,van de Garde MD,Biesta P,Kreefft K,Haagmans B,Zuniga E,Herschke F,De Jonghe S,Janssen HL,Gama L,Boonstra A,Vanwolleghem T
48-0451 was used in Flow cytometry/Cell sorting to demonstrate the enormous functional and genetic plasticity of monocytes infiltrating the liver after inflammation.
Fri May 01 00:00:00 EDT 2015
Abatacept decreases disease activity in a absence of CD4(+) T cells in a collagen-induced arthritis model.
Arthritis research & therapy
Jansen DT,el Bannoudi H,Arens R,Habets KL,Hameetman M,Huizinga TW,Stoop JN,Toes RE
48-0451 was used in Flow cytometry to determine whether the mode of action of abatacept depends solely on its ability to halt T cell activation in established disease.
Thu Aug 20 00:00:00 EDT 2015
Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection.
International journal for parasitology
Bourke CD,Prendergast CT,Sanin DE,Oulton TE,Hall RJ,Mountford AP
48-0451 was used in Flow cytometry/Cell sorting to indicate that S.mansoni cercariae and their excretory/secretory products act directly upon epidermal keratinocytes.
Sun Mar 01 00:00:00 EST 2015
Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model.
Autoimmunity
Atkinson SM,Nansen A,Usher PA,Sondergaard BC,Mackay CR,Friedrichsen B,Chang CC,Tang R,Skov S,Haase C,Hornum L
48-0451 was used in Flow cytometry/Cell sorting to investigate the effect of blocking C5a receptors during early phases of arthritis, showing that it leads to early-onset clinical and mechanistic effects.
Wed Aug 17 00:00:00 EDT 2016
Alveolar macrophage phenotype expression in airway-instilled bone marrow cells in mice.
SpringerPlus
Okui M,Goto T,Asakura K,Kamiyama I,Ohtsuka T
48-0451 was used in Flow cytometry/Cell sorting to study how intratracheally instilled bone marrow cells adapt to the surrounding microenvironment, directly differentiating into alveolar macrophages, and remain in the alveolar space for at least 3 months.
Mon Dec 21 00:00:00 EST 2015
Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion.
The Journal of biological chemistry
Pamir N,Liu NC,Irwin A,Becker L,Peng Y,Ronsein GE,Bornfeldt KE,Duffield JS,Heinecke JW
48-0451 was used in Flow cytometry/Cell sorting to investigate dendritic cells and show cells that are dependent on GM-CSF restrain lean adipose tissue expansion.
Fri Jun 05 00:00:00 EDT 2015
Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross.
PLoS genetics
Gralinski LE,Ferris MT,Aylor DL,Whitmore AC,Green R,Frieman MB,Deming D,Menachery VD,Miller DR,Buus RJ,Bell TA,Churchill GA,Threadgill DW,Katze MG,McMillan L,Valdar W,Heise MT,Pardo-Manuel de Villena F,Baric RS
48-0451 was used in Flow cytometry/Cell sorting to validate the Collaborative Cross platform as a resource for uncovering the genetic contributions of complex traits in microbial diseases, inflammation and viral replication.
Thu Oct 01 00:00:00 EDT 2015
Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation.
Circulation research
Ali SR,Ranjbarvaziri S,Talkhabi M,Zhao P,Subat A,Hojjat A,Kamran P,Müller AM,Volz KS,Tang Z,Red-Horse K,Ardehali R
48-0451 was used in Flow cytometry/Cell sorting to study the developmental origins of cardiac fibroblasts and characterise their corresponding phenotypes, to aid in determining the proliferation rates of each developmental subset.
Fri Sep 12 00:00:00 EDT 2014
Foxp3+ CD4+ T cells improve healing after myocardial infarction by modulating monocyte/macrophage differentiation.
Circulation research
Weirather J,Hofmann UD,Beyersdorf N,Ramos GC,Vogel B,Frey A,Ertl G,Kerkau T,Frantz S
48-0451 was used in Flow cytometry/Cell sorting to determine the mechanisms by which regulatory T cells promote an appropriate healing response after a heart attack.
Fri Jun 20 00:00:00 EDT 2014
Purinergic signaling on leukocytes infiltrating the LPS-injured lung.
PloS one
Friebe D,Yang T,Schmidt T,Borg N,Steckel B,Ding Z,Schrader J
48-0451 was used in Flow cytometry/Cell sorting to investigate the role of extracellular nucleotides/nucleosides in acute lung injury, showing purinergic signaling on leukocytes infiltrating the injured lung.
Thu Jan 15 00:00:00 EST 2015
Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity.
Cell reports
Toso A,Revandkar A,Di Mitri D,Guccini I,Proietti M,Sarti M,Pinton S,Zhang J,Kalathur M,Civenni G,Jarrossay D,Montani E,Marini C,Garcia-Escudero R,Scanziani E,Grassi F,Pandolfi PP,Catapano CV,Alimonti A
48-0451 was used in Flow cytometry/Cell sorting to demonstrate that immune surveillance of senescent tumour cells can be suppressed in specific genetic backgrounds but also evoked by pharmacological treatments.
Thu Oct 09 00:00:00 EDT 2014
Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity.
Molecular therapy. Nucleic acids
Dolina JS,Sung SS,Novobrantseva TI,Nguyen TM,Hahn YS
48-0451 was used in Flow cytometry/Cell sorting to demonstrate that PD-L1 knockdown on KCs is central in determining the outcome of liver viral infections, and they represent a new class of gene therapy.
Tue Feb 19 00:00:00 EST 2013
Differential expression of the Ly49G(B6), but not the Ly49G(BALB), receptor isoform during natural killer cell reconstitution after hematopoietic stem cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Barao I,Wright PW,Sungur CM,Anderson SK,Redelman D,Murphy WJ
48-0451 was used in Flow cytometry/Cell sorting to evaluate the expression of two isoforms of the inhibitory NK cell receptor, Ly49G, in CB6F1 mice following hematopoietic stem cell transplantation.
Tue Oct 01 00:00:00 EDT 2013
Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development.
Journal of immunology (Baltimore, Md. : 1950)
Li J,Zhao Z,Carter C,Ehrlich LI,Bedford MT,Richie ER
48-0451 was used in Flow cytometry/Cell sorting to demonstrate how CARM1 is a key epigenetic regulator of hematopoiesis that affects multiple lineages at various stages of differentiation.
Tue Jan 15 00:00:00 EST 2013
CD11c+ alveolar macrophages are a source of IL-23 during lipopolysaccharide-induced acute lung injury.
Shock (Augusta, Ga.)
Bosmann M,Grailer JJ,Russkamp NF,Ruemmler R,Zetoune FS,Sarma JV,Ward PA
48-0451 was used in Flow cytometry/Cell sorting to investigate the production and downstream effects of IL-23 using a mouse model of lipopolysaccharide-induced acute lung injury.
Wed May 01 00:00:00 EDT 2013
Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis.
PLoS pathogens
Lionakis MS,Fischer BG,Lim JK,Swamydas M,Wan W,Richard Lee CC,Cohen JI,Scheinberg P,Gao JL,Murphy PM
48-0451 was used in Flow cytometry/Cell sorting to show that mice lacking the chemokine receptor Ccr1 have improved renal function and survival without affecting the tissue fungal burden.
Mon Dec 17 00:00:00 EST 2012
Kupffer cells express a unique combination of phenotypic and functional characteristics compared with splenic and peritoneal macrophages.
Journal of leukocyte biology
Movita D,Kreefft K,Biesta P,van Oudenaren A,Leenen PJ,Janssen HL,Boonstra A
48-0451 was used in Flow cytometry/Cell sorting to observe that freshly isolated Kupffer cells are endocytic and show a relatively high basal ROS content.
Mon Oct 01 00:00:00 EDT 2012
Establishment and characterization of a sustained delayed-type hypersensitivity model with arthritic manifestations in C57BL/6J mice.
Arthritis research & therapy
Atkinson SM,Usher PA,Kvist PH,Markholst H,Haase C,Nansen A
48-0451 was used in Flow cytometry/Cell sorting to demonstrate that the DTH-arthritis model could hold potential in the preclinical screening of novel drugs targeting RA.
Thu Jun 07 00:00:00 EDT 2012
Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia.
Journal of neuroinflammation
Horiuchi M,Wakayama K,Itoh A,Kawai K,Pleasure D,Ozato K,Itoh T
48-0451 was used in Flow cytometry/Cell sorting to compare microglial function in wild type and IRF8-deficient mice.
Fri Sep 28 00:00:00 EDT 2012
Epidermal ablation of Dlx3 is linked to IL-17-associated skin inflammation.
Proceedings of the National Academy of Sciences of the United States of America
Hwang J,Kita R,Kwon HS,Choi EH,Lee SH,Udey MC,Morasso MI
48-0451 was used in Flow cytometry/Cell sorting to investigate the role of Distal-less 3 (Dlx3) in cutaneous biology and pathophysiology, showing that ablation is linked to IL-17-associated skin inflammation.
Tue Jul 12 00:00:00 EDT 2011
Tonic BCR signaling represses receptor editing via Raf- and calcium-dependent signaling pathways.
Immunology letters
Ramsey LB,Vegoe AL,Miller AT,Cooke MP,Farrar MA
48-0451 was used in Flow cytometry/Cell sorting to provide evidence that enhanced BCR signalling at the immature B cell stage of development suppresses light chain receptor editing.
Wed Mar 30 00:00:00 EDT 2011
The outcome of polymicrobial sepsis is independent of T and B cells.
Shock (Augusta, Ga.)
Bosmann M,Russkamp NF,Patel VR,Zetoune FS,Sarma JV,Ward PA
48-0451 was used in Flow cytometry/Cell sorting to use mice lacking the recombination activating gene 1 (Rag-1) to study the role of T and B cells in sepsis after cecal ligation and puncture (CLP).
Sat Oct 01 00:00:00 EDT 2011
