Invitrogen

FOXP3 Monoclonal Antibody (FJK-16s), PerCP-Cyanine5.5, eBioscience™

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

97 Published Figures

211 References

View all (163) FOXP3 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

FIGURE: 1 / 99

FOXP3 Antibody (45-5773-82) in Flow

Surface staining of C57BL/6 splenocytes with Anti-Mouse CD4 FITC (Product # 11-0041-82) followed by intracellular staining with 0.125 µg of Rat IgG2a K Isotype Control PerCP-Cyanine5-5 (left) or 0.125 µg of Anti-Mouse/Rat Foxp3 PerCP-Cyanine5-5 (right) using the Foxp3 Staining Buffers (Product # 00-5523-00). Cells in the lymphocyte gate were used for analysis.

Product Image Gallery

FOXP3 Antibody — Intracellular staining of mouse splenocytes. As expected based on known relative expression patterns, Foxp3 clone FJK-16s stains a subset of the CD4+ T cells and does not stain the CD8+ T cells. Details: Balb/c splenocytes were surface stained with CD3 (clone 17A2), CD4 (clone GK1.5) and CD8 (clone 53-6.7), followed by intracellular staining with Foxp3 (clone FJK-16s) using the Foxp3/Transcription Factor Staining Buffer Set and protocol. Lymphocytes in the CD3+CD8+ (blue histogram) and CD3+CD4+ (purple histogram) gates were used for analysis. {RE}

Product Details

45-5773-82

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

0.25 µg/test

View 211 publications 211 publications

Product Specifications

Species Reactivity

Bovine, Dog, Cat, Mouse, Pig, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rat / IgG2a, kappa

Recommended Isotype Control

Rat IgG2a kappa Isotype Control (eBR2a), PerCP-Cyanine5.5, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

FJK-16s

Conjugate

PerCP-Cyanine5.5 PerCP-Cyanine5.5 PerCP-Cyanine5.5

Excitation/Emission Max

489/679 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_914351

Product Specific Information

Description: The FJK-16s antibody reacts with mouse, rat, dog, porcine, bovine and cat Foxp3 also known as FORKHEAD BOX P3, SCURFIN, and JM2; cross reactivity of this antibody to other proteins has not been determined. Foxp3, a 49-55 kDa protein, is a member of the forkhead/winged-helix family of transcriptional regulators, and was identified as the gene defective in 'scurfy' (sf) mice. Constitutive high expression of foxP3 mRNA has been shown in CD4+CD25+ regulatory T cells (Treg cells), and ectopic expression of foxp3 in CD4+CD25- cells imparts a Treg phenotype in these cells.

Immunoblotting with FJK-16s antibody has mapped the epitope to amino acids 75-125 of the mouse Foxp3 protein. In the human, this region has been shown to be alternatively spliced at the mRNA level. Both the alternatively-spliced and non-spliced isoforms are present in the CD4+CD25+ subset of lymphocytes. Preliminary RT-PCR experiments have not revealed this alternatively-spliced isoform in mouse splenocytes, suggesting different gene regulation in the mouse and human.

Please note that FJK-16s has been optimized for use with the Foxp3/Transcription Factor Buffer Staining Set (Product # 00-5523-00). The use of other fixation and staining buffers is not recommended.

Applications Reported: This FJK-16s antibody has been reported for use in intracellular staining followed by flow cytometric analysis.

Applications Tested: This FJK-16s antibody has been tested by intracellular staining of mouse splenocytes using the Foxp3/Transcription Factor Buffer Set (Product # 00-5523-00) and protocol. Please see Best Protocols Section (Staining intracellular Antigens for Flow Cytometry) for staining protocol (refer to Protocol B: One-step protocol for intracellular (nuclear) proteins). This antibody can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 488 nm; Emission: 695 nm; Laser: Blue Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

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Arwood ML,Sun IH,Patel CH,Sun IM,Oh MH,Bettencourt IA,Claiborne MD,Chan-Li Y,Zhao L,Waickman AT,Mavrothalassitis O,Wen J,Aja S,Powell JD

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Jun 01 00:00:00 EDT 2023

A phase I, first-in-human study to evaluate the safety and tolerability, pharmacokinetics, and pharmacodynamics of MRG-001 in healthy subjects.

Cell reports. Medicine

Ahmadi AR,Atiee G,Chapman B,Reynolds L,Sun J,Cameron AM,Wesson RN,Burdick JF,Sun Z

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Sep 19 00:00:00 EDT 2023

The PTP1B Inhibitor Trodusquemine (MSI-1436) Improves Glucose Uptake in Equine Metabolic Syndrome Affected Liver through Anti-Inflammatory and Antifibrotic Activity.

International journal of inflammation

Bourebaba L,Serwotka-Suszczak A,Bourebaba N,Zyzak M,Marycz K

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Oct 10 00:00:00 EDT 2023

Fermented cordyceps powder alleviates silica-induced pulmonary inflammation and fibrosis in rats by regulating the Th immune response.

Chinese medicine

Pu S,Yang Z,Zhang X,Li M,Han N,Yang X,He J,Yu G,Meng X,Jia Q,Shao H

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Oct 12 00:00:00 EDT 2023

Hypertonic Salt Solution Enhances Inflammatory Responses in Cultured Splenic T-Cells from Dahl Salt-Sensitive Rats but Not Dahl Salt-Resistant Rats.

Journal of cardiovascular development and disease

Jang S,Kim JY,Kim CW,Kim I

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Oct 02 00:00:00 EDT 2023

Hypertonic Salt Solution Enhances Inflammatory Responses in Cultured Splenic T-Cells from Dahl Salt-Sensitive Rats but Not Dahl Salt-Resistant Rats.

Journal of cardiovascular development and disease

Jang S,Kim JY,Kim CW,Kim I

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Oct 02 00:00:00 EDT 2023

Berberine plays a cardioprotective role by inhibiting macrophage Wnt5a/β-catenin pathway in the myocardium of mice after myocardial infarction.

Phytotherapy research : PTR

Tian CX,Li MY,Shuai XX,Jiang F,Dong YL,Gui Y,Zhang ZL,Qin RJ,Kang ZY,Lin L,Sarapultsev A,Wu B,Luo SS,Hu DS

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2023

Tumor-specific cholinergic CD4⁺ T lymphocytes guide immunosurveillance of hepatocellular carcinoma.

Nature cancer

Zheng C,Snow BE,Elia AJ,Nechanitzky R,Dominguez-Brauer C,Liu S,Tong Y,Cox MA,Focaccia E,Wakeham AC,Haight J,Tobin C,Hodgson K,Gill KT,Ma W,Berger T,Heikenwälder M,Saunders ME,Fortin J,Leung SY,Mak TW

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Sun Oct 01 00:00:00 EDT 2023

Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer's disease.

Nature communications

Choi BJ,Park MH,Park KH,Han WH,Yoon HJ,Jung HY,Hong JY,Chowdhury MR,Kim KY,Lee J,Song IS,Pang M,Choi MK,Gulbins E,Reichel M,Kornhuber J,Hong CW,Kim C,Kim SH,Schuchman EH,Jin HK,Bae JS

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Mar 24 00:00:00 EDT 2023

Crosstalk between microbiome, regulatory T cells and HCA2 orchestrates the inflammatory response in a murine psoriasis model.

Frontiers in immunology

Schwarz A,Philippsen R,Piticchio SG,Hartmann JN,Häsler R,Rose-John S,Schwarz T

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Mar 27 00:00:00 EDT 2023

SARS-CoV-2 spike protein promotes inflammatory cytokine activation and aggravates rheumatoid arthritis.

Cell communication and signaling : CCS

Lee AR,Woo JS,Lee SY,Lee YS,Jung J,Lee CR,Park SH,Cho ML

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Mar 02 00:00:00 EST 2023

IFN-γ signature enables selection of neoadjuvant treatment in patients with stage III melanoma.

The Journal of experimental medicine

Reijers ILM,Rao D,Versluis JM,Menzies AM,Dimitriadis P,Wouters MW,Spillane AJ,Klop WMC,Broeks A,Bosch LJW,Lopez-Yurda M,van Houdt WJ,Rawson RV,Grijpink-Ongering LG,Gonzalez M,Cornelissen S,Bouwman J,Sanders J,Plasmeijer E,Elshot YS,Scolyer RA,van de Wiel BA,Peeper DS,van Akkooi ACJ,Long GV,Blank CU

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2023

TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions.

Frontiers in immunology

O'Neill TJ,Gewies A,Seeholzer T,Krappmann D

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Feb 13 00:00:00 EST 2023

Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

Aiolos represses CD4⁺ T cell cytotoxic programming via reciprocal regulation of T_FH transcription factors and IL-2 sensitivity.

Nature communications

Read KA,Jones DM,Pokhrel S,Hales EDS,Varkey A,Tuazon JA,Eisele CD,Abdouni O,Saadey A,Leonard MR,Warren RT,Powell MD,Boss JM,Hemann EA,Yount JS,Xin G,Ghoneim HE,Lio CJ,Freud AG,Collins PL,Oestreich KJ

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Mar 24 00:00:00 EDT 2023

Aiolos represses CD4⁺ T cell cytotoxic programming via reciprocal regulation of T_FH transcription factors and IL-2 sensitivity.

Nature communications

Read KA,Jones DM,Pokhrel S,Hales EDS,Varkey A,Tuazon JA,Eisele CD,Abdouni O,Saadey A,Leonard MR,Warren RT,Powell MD,Boss JM,Hemann EA,Yount JS,Xin G,Ghoneim HE,Lio CJ,Freud AG,Collins PL,Oestreich KJ

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Mar 24 00:00:00 EDT 2023

Myeloid TLR4 signaling promotes post-injury withdrawal resolution of murine liver fibrosis.

iScience

Takimoto Y,Chu PS,Nakamoto N,Hagihara Y,Mikami Y,Miyamoto K,Morikawa R,Teratani T,Taniki N,Fujimori S,Suzuki T,Koda Y,Ishihara R,Ichikawa M,Honda A,Kanai T

45-5773-82 was used in flow cytometry to highlight a pro-fibrolytic role of myeloid TLR4 signaling after injury withdrawal and may provide targets for anti-fibrotic therapy.

Fri Mar 17 00:00:00 EDT 2023

miR-126 ameliorates multiple organ dysfunction in septic rats by regulating the differentiation of Th17/Treg.

Molecular biology reports

Zou Q,Liu C,Hu N,Wang W,Wang H

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Apr 01 00:00:00 EDT 2022

Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity.

Cancer cell

Chryplewicz A,Scotton J,Tichet M,Zomer A,Shchors K,Joyce JA,Homicsko K,Hanahan D

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Oct 10 00:00:00 EDT 2022

Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity.

Cancer cell

Chryplewicz A,Scotton J,Tichet M,Zomer A,Shchors K,Joyce JA,Homicsko K,Hanahan D

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Oct 10 00:00:00 EDT 2022

Twelve-week high-fat diet for improving adverse ventricular remodeling post-myocardial infarction by alleviating local inflammation.

Annals of translational medicine

Yang J,Mai B,Su Y,Liang S,Su Z,Chen Y,Xie S

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2022

Protocol to assess cell-intrinsic regulatory mechanisms using an ex vivo murine T cell polarization and co-culture system.

STAR protocols

Ma S,Hernandez JE,Huang WJM

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Sep 16 00:00:00 EDT 2022

Nucleolin Therapeutic Targeting Decreases Pancreatic Cancer Immunosuppression.

Cancers

Ponzo M,Debesset A,Cossutta M,Chalabi-Dchar M,Houppe C,Pilon C,Nicolas-Boluda A,Meunier S,Raineri F,Thiolat A,Nicolle R,Maione F,Brundu S,Cojocaru CF,Bouvet P,Bousquet C,Gazeau F,Tournigand C,Courty J,Giraudo E,Cohen JL,Cascone I

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Aug 31 00:00:00 EDT 2022

Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells.

EMBO reports

Lopez Krol A,Nehring HP,Krause FF,Wempe A,Raifer H,Nist A,Stiewe T,Bertrams W,Schmeck B,Luu M,Leister H,Chung HR,Bauer UM,Adhikary T,Visekruna A

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Dec 06 00:00:00 EST 2022

Impaired Treg-DC interactions contribute to autoimmunity in leukocyte adhesion deficiency type 1.

JCI insight

Klaus T,Wilson AS,Vicari E,Hadaschik E,Klein M,Helbich SSC,Kamenjarin N,Hodapp K,Schunke J,Haist M,Butsch F,Probst HC,Enk AH,Mahnke K,Waisman A,Bednarczyk M,Bros M,Bopp T,Grabbe S

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Dec 22 00:00:00 EST 2022

Impad1 and Syt11 work in an epistatic pathway that regulates EMT-mediated vesicular trafficking to drive lung cancer invasion and metastasis.

Cell reports

Bajaj R,Rodriguez BL,Russell WK,Warner AN,Diao L,Wang J,Raso MG,Lu W,Khan K,Solis LS,Batra H,Tang X,Fradette JF,Kundu ST,Gibbons DL

45-5773-82 was used in Flow cytometry/Cell sorting to identify Impad1 as a regulator of EMT and secretome-mediated changes during lung cancer progression.

Tue Sep 27 00:00:00 EDT 2022

Inhibition of PDE4 by apremilast attenuates skin fibrosis through directly suppressing activation of M1 and T cells.

Acta pharmacologica Sinica

Lu QK,Fan C,Xiang CG,Wu B,Lu HM,Feng CL,Yang XQ,Li H,Tang W

45-5773-82 was used in Flow cytometry/Cell sorting to suggested that inhibiting PDE4 by apremilast might provide a novel therapeutic option for clinical treatment of systemic sclerosis (SSc) patients.

Tue Feb 01 00:00:00 EST 2022

Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections.

Immunity

Harb H,Benamar M,Lai PS,Contini P,Griffith JW,Crestani E,Schmitz-Abe K,Chen Q,Fong J,Marri L,Filaci G,Del Zotto G,Pishesha N,Kolifrath S,Broggi A,Ghosh S,Gelmez MY,Oktelik FB,Cetin EA,Kiykim A,Kose M,Wang Z,Cui Y,Yu XG,Li JZ,Berra L,Stephen-Victor E,Charbonnier LM,Zanoni I,Ploegh H,Deniz G,De Palma R,Chatila TA

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Jun 08 00:00:00 EDT 2021

Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility.

The Journal of experimental medicine

Wirasinha RC,Davies AR,Srivastava M,Sheridan JM,Sng XYX,Delmonte OM,Dobbs K,Loh KL,Miosge LA,Lee CE,Chand R,Chan A,Yap JY,Keller MD,Chen K,Rossjohn J,La Gruta NL,Vinuesa CG,Reid HH,Lionakis MS,Notarangelo LD,Gray DHD,Goodnow CC,Cook MC,Daley SR

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

CYBB/NOX2 in conventional DCs controls T cell encephalitogenicity during neuroinflammation.

Autophagy

Keller CW,Kotur MB,Mundt S,Dokalis N,Ligeon LA,Shah AM,Prinz M,Becher B,Münz C,Lünemann JD

45-5773-82 was used in Sample Preparation to report that the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2, also known as CYBB/NOX2, in conventional DCs (cDCs) regulates endocytosed MOG (myelin oligodendrocyte protein) antigen processing and supports MOG-antigen presentation to CD4+ T cells through LC3-associated phagocytosis (LAP).

Sat May 01 00:00:00 EDT 2021

IL1β Promotes Immune Suppression in the Tumor Microenvironment Independent of the Inflammasome and Gasdermin D.

Cancer immunology research

Kiss M,Vande Walle L,Saavedra PHV,Lebegge E,Van Damme H,Murgaski A,Qian J,Ehling M,Pretto S,Bolli E,Keirsse J,Bardet PMR,Arnouk SM,Elkrim Y,Schmoetten M,Brughmans J,Debraekeleer A,Fossoul A,Boon L,Raes G,van Loo G,Lambrechts D,Mazzone M,Beschin A,Wullaert A,Lamkanfi M,Van Ginderachter JA,Laoui D

45-5773-82 was used in Flow Cytometry to investigate roles for IL1β in driving tumor progression in two distinct mouse tumor models.

Mon Mar 01 00:00:00 EST 2021

Ubiquitin-specific peptidase 18 regulates the differentiation and function of Treg cells.

Genes & diseases

Yang L,Jing Y,Kang D,Jiang P,Li N,Zhou X,Chen Y,Westerberg LS,Liu C

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Thymic atrophy creates holes in Treg-mediated immuno-regulation via impairment of an antigen-specific clone.

Immunology

Thomas R,Oh J,Wang W,Su DM

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Sun Aug 01 00:00:00 EDT 2021

Romidepsin (FK228) regulates the expression of the immune checkpoint ligand PD-L1 and suppresses cellular immune functions in colon cancer.

Cancer immunology, immunotherapy : CII

Shi Y,Fu Y,Zhang X,Zhao G,Yao Y,Guo Y,Ma G,Bai S,Li H

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2021

Sirt6 Regulates the Development of Medullary Thymic Epithelial Cells and Contributes to the Establishment of Central Immune Tolerance.

Frontiers in cell and developmental biology

Zhang Q,Liang Z,Zhang J,Lei T,Dong X,Su H,Chen Y,Zhang Z,Tan L,Zhao Y

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Apr 21 00:00:00 EDT 2021

HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1 Expression.

Journal of immunology (Baltimore, Md. : 1950)

Rowswell-Turner RB,Singh RK,Urh A,Yano N,Kim KK,Khazan N,Pandita R,Sivagnanalingam U,Hovanesian V,James NE,Ribeiro JR,Kadambi S,Linehan DC,Moore RG

45-5773-82 was used in Flow cytometry/Cell sorting to identify HE4 as a mediator of tumor-immune suppression in ovarian cancer, highlighting this molecule as a potential therapeutic target for the treatment of this devastating disease.

Sat May 15 00:00:00 EDT 2021

Generation of a Novel Oncolytic Vaccinia Virus Using the IHD-W Strain.

Human gene therapy

Shin J,Hong SO,Kim M,Lee H,Choi H,Kim J,Hong J,Kang H,Lee E,Lee S,Kong B,Kim M,Choi H,Kim S

45-5773 was used in Flow cytometry/Cell sorting to develope a novel oncolytic vaccinia virus with high potency and a favorable safety profile.

Sat May 01 00:00:00 EDT 2021

Transfer of Th17 from Adult Spontaneous Hypertensive Rats Accelerates Development of Hypertension in Juvenile Spontaneous Hypertensive Rats.

BioMed research international

Kim JY,Lee E,Koo S,Kim CW,Kim I

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue May 25 00:00:00 EDT 2021

Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.

The Journal of international medical research

Li W,Luo Y,Xu H,Ma Q,Yao Q

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Apr 01 00:00:00 EDT 2021

Intratumoral expression of interleukin 23 variants using oncolytic vaccinia virus elicit potent antitumor effects on multiple tumor models via tumor microenvironment modulation.

Theranostics

Chen L,Chen H,Ye J,Ge Y,Wang H,Dai E,Ren J,Liu W,Ma C,Ju S,Guo ZS,Liu Z,Bartlett DL

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Aug 04 00:00:00 EDT 2021

Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model.

Vaccines

Trofimova O,Korotkaja K,Skrastina D,Jansons J,Spunde K,Isaguliants M,Zajakina A

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Oct 27 00:00:00 EDT 2021

IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation.

Frontiers in immunology

Amobi-McCloud A,Muthuswamy R,Battaglia S,Yu H,Liu T,Wang J,Putluri V,Singh PK,Qian F,Huang RY,Putluri N,Tsuji T,Lugade AA,Liu S,Odunsi K

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Oct 29 00:00:00 EDT 2021

The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia.

Journal of neuroinflammation

Malone K,Diaz Diaz AC,Shearer JA,Moore AC,Waeber C

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Sat Jan 30 00:00:00 EST 2021

ILC3s control airway inflammation by limiting T cell responses to allergens and microbes.

Cell reports

Teng F,Tachó-Piñot R,Sung B,Farber DL,Worgall S,Hammad H,Lambrecht BN,Hepworth MR,Sonnenberg GF

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Nov 23 00:00:00 EST 2021

Dual Role of Interleukin-10 in Murine NZB/W F1 Lupus.

International journal of molecular sciences

Amend A,Wickli N,Schäfer AL,Sprenger DTL,Manz RA,Voll RE,Chevalier N

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Jan 29 00:00:00 EST 2021

Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology.

Science advances

Da Mesquita S,Herz J,Wall M,Dykstra T,de Lima KA,Norris GT,Dabhi N,Kennedy T,Baker W,Kipnis J

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.

Theranostics

Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Jan 28 00:00:00 EST 2022

Rodent Models of Spondyloarthritis Have Decreased White and Bone Marrow Adipose Tissue Depots.

Frontiers in immunology

Furesi G,Fert I,Beaufrère M,Araujo LM,Glatigny S,Baschant U,von Bonin M,Hofbauer LC,Horwood NJ,Breban M,Rauner M

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Oct 25 00:00:00 EDT 2021

Anti-PD-1 Checkpoint Therapy Can Promote the Function and Survival of Regulatory T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Vick SC,Kolupaev OV,Perou CM,Serody JS

45-5773-82 was used in Flow cytometry/Cell sorting to show that this immunotherapy blockade increases proliferation, protection from apoptosis, and suppressive capabilities of Tregs, thus leading to enhanced immunosuppression in the TME.

Mon Nov 15 00:00:00 EST 2021

A collagen glucosyltransferase drives lung adenocarcinoma progression in mice.

Communications biology

Guo HF,Bota-Rabassedas N,Terajima M,Leticia Rodriguez B,Gibbons DL,Chen Y,Banerjee P,Tsai CL,Tan X,Liu X,Yu J,Tokmina-Roszyk M,Stawikowska R,Fields GB,Miller MD,Wang X,Lee J,Dalby KN,Creighton CJ,Phillips GN,Tainer JA,Yamauchi M,Kurie JM

45-5773-82 was used in Flow cytometry/Cell sorting to identify a previously unrecognized collagen GGT activity that drives LUAD progression.

Mon Apr 19 00:00:00 EDT 2021

Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.

Frontiers in immunology

Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Jul 05 00:00:00 EDT 2021

p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi.

Science advances

Tan X,Banerjee P,Shi L,Xiao GY,Rodriguez BL,Grzeskowiak CL,Liu X,Yu J,Gibbons DL,Russell WK,Creighton CJ,Kurie JM

45-5773-82 was used in Flow Cytometry to show that p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi.

Tue Jun 01 00:00:00 EDT 2021

MAFG-driven astrocytes promote CNS inflammation.

Nature

Wheeler MA,Clark IC,Tjon EC,Li Z,Zandee SEJ,Couturier CP,Watson BR,Scalisi G,Alkwai S,Rothhammer V,Rotem A,Heyman JA,Thaploo S,Sanmarco LM,Ragoussis J,Weitz DA,Petrecca K,Moffitt JR,Becher B,Antel JP,Prat A,Quintana FJ

45-5773-82 was used in Flow Cytometry to identify candidate therapeutic targets in multiple sclerosis.

Sat Feb 01 00:00:00 EST 2020

Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy.

Cell

Jiang L,Wang YJ,Zhao J,Uehara M,Hou Q,Kasinath V,Ichimura T,Banouni N,Dai L,Li X,Greiner DL,Shultz LD,Zhang X,Sun ZJ,Curtin I,Vangos NE,Yeoh ZC,Geffken EA,Seo HS,Liu ZX,Heffron GJ,Shah K,Dhe-Paganon S,Abdi R

45-5773 was used in Flow cytometry/Cell sorting to describe a molecular target that permits a combination of tumor ablation, interference within the TME, and immunotherapy in one potential modality.

Wed Nov 25 00:00:00 EST 2020

A Genome-wide CRISPR Screen Reveals a Role for the Non-canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function.

Immunity

Loo CS,Gatchalian J,Liang Y,Leblanc M,Xie M,Ho J,Venkatraghavan B,Hargreaves DC,Zheng Y

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Jul 14 00:00:00 EDT 2020

Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.

The Journal of clinical investigation

Webb LM,Sengupta S,Edell C,Piedra-Quintero ZL,Amici SA,Miranda JN,Bevins M,Kennemer A,Laliotis G,Tsichlis PN,Guerau-de-Arellano M

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

Protection of Batf3-deficient mice from experimental cerebral malaria correlates with impaired cytotoxic T-cell responses and immune regulation.

Immunology

Kuehlwein JM,Borsche M,Korir PJ,Risch F,Mueller AK,Hübner MP,Hildner K,Hoerauf A,Dunay IR,Schumak B

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Sat Feb 01 00:00:00 EST 2020

Activated pathogenic Th17 lymphocytes induce hypertension following high-fructose intake in Dahl salt-sensitive but not Dahl salt-resistant rats.

Disease models & mechanisms

Lee E,Kim N,Kang J,Yoon S,Lee HA,Jung H,Kim SH,Kim I

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed May 27 00:00:00 EDT 2020

MOSPD2 is a therapeutic target for the treatment of CNS inflammation.

Clinical and experimental immunology

Yacov N,Kafri P,Salem Y,Propheta-Meiran O,Feldman B,Breitbart E,Mendel I

45-5773 was used in Flow cytometry/Cell sorting to study the therapeutic potential of MOSPD2 in central nervous system disease.

Sat Aug 01 00:00:00 EDT 2020

Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.

Journal of cellular and molecular medicine

Wu R,Liu C,Deng X,Chen L,Hao S,Ma L

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

A novel inhibitory role of microRNA-224 in particulate matter 2.5-induced asthmatic mice by inhibiting TLR2.

Journal of cellular and molecular medicine

Li P,Wang J,Guo F,Zheng B,Zhang X

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2020

A Phase I, Dose Escalation, Single Dose Trial of Oral Attenuated Salmonella typhimurium Containing Human IL-2 in Patients With Metastatic Gastrointestinal Cancers.

Journal of immunotherapy (Hagerstown, Md. : 1997)

Gniadek TJ,Augustin L,Schottel J,Leonard A,Saltzman D,Greeno E,Batist G

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2020

HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.

Journal of Cancer

Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Japanese Kampo Medicine Juzentaihoto Enhances Antitumor Immunity in CD1d^-/- Mice Lacking NKT Cells.

Integrative cancer therapies

Takaku S,Shimizu M,Takahashi H

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Mar 23 00:00:00 EDT 2020

Horses with equine recurrent uveitis have an activated CD4+ T-cell phenotype that can be modulated by mesenchymal stem cells in vitro.

Veterinary ophthalmology

Saldinger LK,Nelson SG,Bellone RR,Lassaline M,Mack M,Walker NJ,Borjesson DL

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

Dietary Glucose Consumption Promotes RALDH Activity in Small Intestinal CD103⁺CD11b⁺ Dendritic Cells.

Frontiers in immunology

Ko HJ,Hong SW,Verma R,Jung J,Lee M,Kim N,Kim D,Surh CD,Kim KS,Rudra D,Im SH

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Apr 19 00:00:00 EDT 2021

Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease.

Cell reports

Nguyen HD,Ticer T,Bastian D,Kuril S,Li H,Du H,Yan C,Yu XZ

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Oct 27 00:00:00 EDT 2020

Assessing IL-2-Induced STAT5 Phosphorylation in Fixed, Permeabilized Foxp3⁺ Treg Cells by Multiparameter Flow Cytometry.

STAR protocols

Li C,Park JH

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Dec 18 00:00:00 EST 2020

Follicular Regulatory T Cells Can Access the Germinal Center Independently of CXCR5.

Cell reports

Vanderleyden I,Fra-Bido SC,Innocentin S,Stebegg M,Okkenhaug H,Evans-Bailey N,Pierson W,Denton AE,Linterman MA

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Jan 21 00:00:00 EST 2020

FOXD3 Regulates VISTA Expression in Melanoma.

Cell reports

Rosenbaum SR,Knecht M,Mollaee M,Zhong Z,Erkes DA,McCue PA,Chervoneva I,Berger AC,Lo JA,Fisher DE,Gershenwald JE,Davies MA,Purwin TJ,Aplin AE

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Jan 14 00:00:00 EST 2020

Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy.

Nature communications

Baumann D,Hägele T,Mochayedi J,Drebant J,Vent C,Blobner S,Noll JH,Nickel I,Schumacher C,Boos SL,Daniel AS,Wendler S,Volkmar M,Strobel O,Offringa R

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2020

Donor bone-marrow CXCR4+ Foxp3+ T-regulatory cells are essential for costimulation blockade-induced long-term survival of murine limb transplants.

Scientific reports

Wang L,Wang Z,Han R,Samanta A,Ge G,Levin LS,Levine MH,Hancock WW

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Jun 09 00:00:00 EDT 2020

Host deficiency in ephrin-A1 inhibits breast cancer metastasis.

F1000Research

Shiuan E,Inala A,Wang S,Song W,Youngblood V,Chen J,Brantley-Sieders DM

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Respiratory Syncytial Virus Infection Reduces Kynurenic Acid Production and Reverses Th17/Treg Balance by Modulating Indoleamine 2,3-Dioxygenase (IDO) Molecules in Plasmacytoid Dendritic Cells.

Medical science monitor : international medical journal of experimental and clinical research

Jin L,Hu Q,Hu Y,Chen Z,Liao W

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Dec 02 00:00:00 EST 2020

Respiratory Syncytial Virus Infection Reduces Kynurenic Acid Production and Reverses Th17/Treg Balance by Modulating Indoleamine 2,3-Dioxygenase (IDO) Molecules in Plasmacytoid Dendritic Cells.

Medical science monitor : international medical journal of experimental and clinical research

Jin L,Hu Q,Hu Y,Chen Z,Liao W

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Dec 02 00:00:00 EST 2020

Treatment of mice with a ligand binding blocking anti-CD28 monoclonal antibody improves healing after myocardial infarction.

PloS one

Gladow N,Hollmann C,Ramos G,Frantz S,Kerkau T,Beyersdorf N,Hofmann U

45-5773 was used in Flow cytometry/Cell sorting to demonstrate that CD28-dependent costimulation of CD4+ T-cells impairs myocardial healing.

Mon Jul 06 00:00:00 EDT 2020

Treatment of mice with a ligand binding blocking anti-CD28 monoclonal antibody improves healing after myocardial infarction.

PloS one

Gladow N,Hollmann C,Ramos G,Frantz S,Kerkau T,Beyersdorf N,Hofmann U

45-5773 was used in Flow cytometry/Cell sorting to demonstrate that CD28-dependent costimulation of CD4+ T-cells impairs myocardial healing.

Mon Jul 06 00:00:00 EDT 2020

3'-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models.

Scientific reports

Kang LJ,Oh E,Cho C,Kwon H,Lee CG,Jeon J,Lee H,Choi S,Han SJ,Nam J,Song CU,Jung H,Kim HY,Park EJ,Choi EJ,Kim J,Eyun SI,Yang S

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Mar 27 00:00:00 EDT 2020

Ginsenoside RG1 enhances the paracrine effects of bone marrow-derived mesenchymal stem cells on radiation induced intestinal injury.

Aging

Luo Y,Wang B,Liu J,Ma F,Luo D,Zheng Z,Lu Q,Zhou W,Zheng Y,Zhang C,Wang Q,Sha W,Chen H

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Dec 03 00:00:00 EST 2020

Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Restructures the Immune Contexture to Improve Checkpoint Blockade Efficacy.

Biomedicines

Ebelt ND,Zuniga E,Marzagalli M,Zamloot V,Blazar BR,Salgia R,Manuel ER

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Dec 16 00:00:00 EST 2020

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine.

Nature communications

Campesato LF,Budhu S,Tchaicha J,Weng CH,Gigoux M,Cohen IJ,Redmond D,Mangarin L,Pourpe S,Liu C,Zappasodi R,Zamarin D,Cavanaugh J,Castro AC,Manfredi MG,McGovern K,Merghoub T,Wolchok JD

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Aug 11 00:00:00 EDT 2020

Foxo3 Promotes the Differentiation and Function of Follicular Helper T Cells.

Cell reports

Qi H,Tian D,Li M,Zhang C,Jin H,Liu L,Zhao X,Ma L,Zhao W,Ge Q,Duan T,Zhang D

45-5773 was used in Flow cytometry/Cell sorting to unveil a critical role of Foxo3 in the regulation of Tfh differentiation and IL-21 production.

Tue May 12 00:00:00 EDT 2020

A micropeptide encoded by lncRNA MIR155HG suppresses autoimmune inflammation via modulating antigen presentation.

Science advances

Niu L,Lou F,Sun Y,Sun L,Cai X,Liu Z,Zhou H,Wang H,Wang Z,Bai J,Yin Q,Zhang J,Chen L,Peng D,Xu Z,Gao Y,Tang S,Fan L,Wang H

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri May 01 00:00:00 EDT 2020

Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses.

Scientific reports

Hrdý J,Alard J,Couturier-Maillard A,Boulard O,Boutillier D,Delacre M,Lapadatescu C,Cesaro A,Blanc P,Pot B,Ryffel B,Chamaillard M,Grangette C

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Mar 24 00:00:00 EDT 2020

Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development.

Cell reports

Ramstead AG,Wallace JA,Lee SH,Bauer KM,Tang WW,Ekiz HA,Lane TE,Cluntun AA,Bettini ML,Round JL,Rutter J,O'Connell RM

45-5773 was used in Flow cytometry/Cell sorting to demonstrate that pyruvate oxidation by T cell precursors is necessary for optimal αβ T cell development.

Tue Mar 03 00:00:00 EST 2020

Mesenchymal stromal cells induce distinct myeloid-derived suppressor cells in inflammation.

JCI insight

Lee HJ,Ko JH,Kim HJ,Jeong HJ,Oh JY

45-5773 was used in Flow cytometry/Cell sorting to reveal that suppression of prostaglandin E2 (PGE2) and HGF secretion in MSCs by siRNA transfection partially reversed the effects of MSCs on MDSC differentiation.

Thu Jun 18 00:00:00 EDT 2020

Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.

Nature communications

Sidwell T,Liao Y,Garnham AL,Vasanthakumar A,Gloury R,Blume J,Teh PP,Chisanga D,Thelemann C,de Labastida Rivera F,Engwerda CR,Corcoran L,Kometani K,Kurosaki T,Smyth GK,Shi W,Kallies A

45-5773 was used in Flow cytometry/Cell sorting to show homeostasis of thymically-derived and peripherally-derived Treg cells is maintained through the balancing of TCR signaling induced transcriptional activity by Bach2.

Tue Jan 14 00:00:00 EST 2020

IFN-γ promoted exosomes from mesenchymal stem cells to attenuate colitis via miR-125a and miR-125b.

Cell death & disease

Yang R,Huang H,Cui S,Zhou Y,Zhang T,Zhou Y

45-5773-82 was used in Flow Cytometry to investigate the potential anti-inflammatory effects of bone marrow mesenchymal stem cell-derived exosomes.

Thu Jul 30 00:00:00 EDT 2020

Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth.

Cell reports

Davidson S,Efremova M,Riedel A,Mahata B,Pramanik J,Huuhtanen J,Kar G,Vento-Tormo R,Hagai T,Chen X,Haniffa MA,Shields JD,Teichmann SA

45-5773-82 was used in Flow Cytometry to identify complex interplays and increase stromal diversity as a tumor develops, revealing that stromal cells acquire the capacity to modulate immune landscapes from early disease.

Tue May 19 00:00:00 EDT 2020

Axenic Caenorhabditis elegans antigen protects against development of type-1 diabetes in NOD mice.

Journal of translational autoimmunity

Jackson-Thompson BM,Torrero M,Mitre BK,Long J,Packiam M,Mitre E

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Compartmentalized gut lymph node drainage dictates adaptive immune responses.

Nature

Esterházy D,Canesso MCC,Mesin L,Muller PA,de Castro TBR,Lockhart A,ElJalby M,Faria AMC,Mucida D

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed May 01 00:00:00 EDT 2019

Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS.

Cell

Chao CC,Gutiérrez-Vázquez C,Rothhammer V,Mayo L,Wheeler MA,Tjon EC,Zandee SEJ,Blain M,de Lima KA,Takenaka MC,Avila-Pacheco J,Hewson P,Liu L,Sanmarco LM,Borucki DM,Lipof GZ,Trauger SA,Clish CB,Antel JP,Prat A,Quintana FJ

45-5773-82 was used in Flow Cytometry to define a novel immunometabolic mechanism that drives pro-inflammatory astrocyte activities.

Thu Dec 12 00:00:00 EST 2019

The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.

Cell

Collins N,Han SJ,Enamorado M,Link VM,Huang B,Moseman EA,Kishton RJ,Shannon JP,Dixit D,Schwab SR,Hickman HD,Restifo NP,McGavern DB,Schwartzberg PL,Belkaid Y

45-5773-82 was used in Flow Cytometry to show that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction (DR) but dramatically accumulated within the bone marrow (BM), where they adopted a state associated with energy conservation.

Thu Aug 22 00:00:00 EDT 2019

Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy.

Cell research

Zhang Y,Du X,Liu M,Tang F,Zhang P,Ai C,Fields JK,Sundberg EJ,Latinovic OS,Devenport M,Zheng P,Liu Y

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Aug 01 00:00:00 EDT 2019

Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells.

Immunity

Tibbitt CA,Stark JM,Martens L,Ma J,Mold JE,Deswarte K,Oliynyk G,Feng X,Lambrecht BN,De Bleser P,Nylén S,Hammad H,Arsenian Henriksson M,Saeys Y,Coquet JM

45-5773-82 was used in Flow cytometry/Cell sorting to provide insight into the differentiation of pathogenic Th2 cells in the context of allergy.

Tue Jul 16 00:00:00 EDT 2019

Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis.

Cell host & microbe

Gogokhia L,Buhrke K,Bell R,Hoffman B,Brown DG,Hanke-Gogokhia C,Ajami NJ,Wong MC,Ghazaryan A,Valentine JF,Porter N,Martens E,O'Connell R,Jacob V,Scherl E,Crawford C,Stephens WZ,Casjens SR,Longman RS,Round JL

45-5773 was used in Flow cytometry/Cell sorting to indicate that bacteriophages can alter mucosal immunity to impact mammalian health.

Wed Feb 13 00:00:00 EST 2019

Inhibition of phosphodiesterase-4 attenuates murine ulcerative colitis through interference with mucosal immunity.

British journal of pharmacology

Li H,Fan C,Feng C,Wu Y,Lu H,He P,Yang X,Zhu F,Qi Q,Gao Y,Zuo J,Tang W

45-5773 was used in Flow cytometry/Cell sorting to demonstrate that inhibition of PDE4 by apremilast protected against ulcerative colitis, by interfering with mucosal immunity in mice.

Mon Jul 01 00:00:00 EDT 2019

Consequences of early postnatal lipopolysaccharide exposure on developing lungs in mice.

American journal of physiology. Lung cellular and molecular physiology

Shrestha AK,Bettini ML,Menon RT,Gopal VYN,Huang S,Edwards DP,Pammi M,Barrios R,Shivanna B

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2019

Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.

Laboratory investigation; a journal of technical methods and pathology

Hensel JA,Khattar V,Ashton R,Ponnazhagan S

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2019

Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway.

Mediators of inflammation

Xu Y,Tang X,Yang M,Zhang S,Li S,Chen Y,Liu M,Guo Y,Lu M

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Jun 11 00:00:00 EDT 2019

Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.

Anti-cancer drugs

Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

Mast Cells Are Mediators of Fibrosis and Effector Cell Recruitment in Dermal Chronic Graft-vs.-Host Disease.

Frontiers in immunology

Strattan E,Palaniyandi S,Kumari R,Du J,Hakim N,Huang T,Kesler MV,Jennings CD,Sturgill JL,Hildebrandt GC

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Nov 17 00:00:00 EST 2020

Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.

Frontiers in immunology

Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Oct 14 00:00:00 EDT 2020

Loss of TET2 and TET3 in regulatory T cells unleashes effector function.

Nature communications

Yue X,Lio CJ,Samaniego-Castruita D,Li X,Rao A

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed May 01 00:00:00 EDT 2019

Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.

Nature communications

Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue May 14 00:00:00 EDT 2019

Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth.

Nature communications

Kusano T,Ehirchiou D,Matsumura T,Chobaz V,Nasi S,Castelblanco M,So A,Lavanchy C,Acha-Orbea H,Nishino T,Okamoto K,Busso N

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Oct 28 00:00:00 EDT 2019

Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis.

Scientific reports

Brichacek AL,Benkovic SA,Chakraborty S,Nwafor DC,Wang W,Jun S,Dakhlallah D,Geldenhuys WJ,Pinkerton AB,Millán JL,Brown CM

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Dec 11 00:00:00 EST 2019

A20 as an immune tolerance factor can determine islet transplant outcomes.

JCI insight

Zammit NW,Walters SN,Seeberger KL,O'Connell PJ,Korbutt GS,Grey ST

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Nov 01 00:00:00 EDT 2019

Anti-IL-6 eluting immunomodulatory biomaterials prolong skin allograft survival.

Scientific reports

Uehara M,Li X,Sheikhi A,Zandi N,Walker B,Saleh B,Banouni N,Jiang L,Ordikhani F,Dai L,Yonar M,Vohra I,Kasinath V,Orgill DP,Khademhosseini A,Annabi N,Abdi R

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Apr 25 00:00:00 EDT 2019

Requirement of Mitochondrial Transcription Factor A in Tissue-Resident Regulatory T Cell Maintenance and Function.

Cell reports

Fu Z,Ye J,Dean JW,Bostick JW,Weinberg SE,Xiong L,Oliff KN,Chen ZE,Avram D,Chandel NS,Zhou L

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Jul 02 00:00:00 EDT 2019

Sex Differences in Mouse Popliteal Lymph Nodes.

Scientific reports

Dill-Garlow R,Chen KE,Walker AM

45-5773 was used in Flow cytometry/Cell sorting to investigate the underlying sex differences that may contribute to differential footpad delayed-type hypersensitivity responses using wildtype and four core genotypes mice and popliteal lymphnode cellularity and gene expression.

Wed Jan 30 00:00:00 EST 2019

Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.

Cell

Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Jun 28 00:00:00 EDT 2018

Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity.

Immunity

Shi H,Liu C,Tan H,Li Y,Nguyen TM,Dhungana Y,Guy C,Vogel P,Neale G,Rankin S,Feng Y,Peng J,Tao W,Chi H

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Nov 20 00:00:00 EST 2018

Non-conventional Inhibitory CD4⁺Foxp3^-PD-1^hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity.

Cancer cell

Zappasodi R,Budhu S,Hellmann MD,Postow MA,Senbabaoglu Y,Manne S,Gasmi B,Liu C,Zhong H,Li Y,Huang AC,Hirschhorn-Cymerman D,Panageas KS,Wherry EJ,Merghoub T,Wolchok JD

45-5773-82 was used in Flow Cytometry to provide evidence that mouse and human circulating and intra-tumor 4PD1hi inhibit T cell functions in a PD-1/PD-L1 dependent fashion and resemble follicular helper T cell (TFH)-like cells.

Mon Jun 11 00:00:00 EDT 2018

PPARγ deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects.

The Journal of clinical investigation

Kraakman MJ,Liu Q,Postigo-Fernandez J,Ji R,Kon N,Larrea D,Namwanje M,Fan L,Chan M,Area-Gomez E,Fu W,Creusot RJ,Qiang L

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Jun 01 00:00:00 EDT 2018

Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling.

The Journal of clinical investigation

Emmerson A,Trevelin SC,Mongue-Din H,Becker PD,Ortiz C,Smyth LA,Peng Q,Elgueta R,Sawyer G,Ivetic A,Lechler RI,Lombardi G,Shah AM

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Jul 02 00:00:00 EDT 2018

MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance.

Autophagy

Liang Z,Zhang L,Su H,Luan R,Na N,Sun L,Zhao Y,Zhang X,Zhang Q,Li J,Zhang L,Zhao Y

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Mar 22 00:00:00 EDT 2019

Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.

Molecular therapy : the journal of the American Society of Gene Therapy

Ricca JM,Oseledchyk A,Walther T,Liu C,Mangarin L,Merghoub T,Wolchok JD,Zamarin D

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Apr 04 00:00:00 EDT 2018

Bryostatin-1 alleviates experimental multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America

Kornberg MD,Smith MD,Shirazi HA,Calabresi PA,Snyder SH,Kim PM

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Feb 27 00:00:00 EST 2018

Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function.

British journal of pharmacology

Lu Y,Kim NM,Jiang YW,Zhang H,Zheng D,Zhu FX,Liang R,Li B,Xu HX

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Sun Apr 01 00:00:00 EDT 2018

Tolerogenic Nanoparticles Induce Antigen-Specific Regulatory T Cells and Provide Therapeutic Efficacy and Transferrable Tolerance against Experimental Autoimmune Encephalomyelitis.

Frontiers in immunology

LaMothe RA,Kolte PN,Vo T,Ferrari JD,Gelsinger TC,Wong J,Chan VT,Ahmed S,Srinivasan A,Deitemeyer P,Maldonado RA,Kishimoto TK

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Mar 21 00:00:00 EDT 2019

CD4⁺ T Cell Fate Decisions Are Stochastic, Precede Cell Division, Depend on GITR Co-Stimulation, and Are Associated With Uropodium Development.

Frontiers in immunology

Cobbold SP,Adams E,Howie D,Waldmann H

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Jan 31 00:00:00 EST 2022

Indirect presentation in the thymus limits naive and regulatory T-cell differentiation by promoting deletion of self-reactive thymocytes.

Immunology

Yap JY,Wirasinha RC,Chan A,Howard DR,Goodnow CC,Daley SR

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Sun Jul 01 00:00:00 EDT 2018

TRPM2 Exacerbates Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis by Increasing Production of CXCL2 Chemokines.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Tsutsui M,Hirase R,Miyamura S,Nagayasu K,Nakagawa T,Mori Y,Shirakawa H,Kaneko S

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Sep 26 00:00:00 EDT 2018

PDL-1 Blockade Prevents T Cell Exhaustion, Inhibits Autophagy, and Promotes Clearance of Leishmania donovani.

Infection and immunity

Habib S,El Andaloussi A,Elmasry K,Handoussa A,Azab M,Elsawey A,Al-Hendy A,Ismail N

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Jun 01 00:00:00 EDT 2018

Immunological effects of a low-dose cytarabine, aclarubicin and granulocyte-colony stimulating factor priming regimen on a mouse leukemia model.

Oncology letters

Chen J,Yang N,Liu H,Yao H,Wang J,Yang Y,Zhang W

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Sat Sep 01 00:00:00 EDT 2018

Assessment of tumor growth factor-β1 neutralizing antibody in the treatment of allergic rhinitis and asthma.

Experimental and therapeutic medicine

Wei Y,Zhang Z,Wang F,Zhou S

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Jan 01 00:00:00 EST 2018

Combined treatment with simvastatin and rapamycin attenuates cardiac allograft rejection through the regulation of T helper 17 and regulatory T cells.

Experimental and therapeutic medicine

Liu Y,Sun L,Chen W,Chuai J,Shang Y,Zhang D,Fu B,Tian H,Jiang S

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3⁺RORγt⁺ Regulatory T Cells.

Cell reports

Ogawa C,Bankoti R,Nguyen T,Hassanzadeh-Kiabi N,Nadeau S,Porritt RA,Couse M,Fan X,Dhall D,Eberl G,Ohnmacht C,Martins GA

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Oct 02 00:00:00 EDT 2018

Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice.

Scientific reports

Quan S,Principe DR,Dean AE,Park SH,Grippo PJ,Gius D,Horikoshi N

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Nov 07 00:00:00 EST 2018

Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.

Nature communications

Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Nov 08 00:00:00 EST 2018

REV-ERBα Regulates T_H17 Cell Development and Autoimmunity.

Cell reports

Amir M,Chaudhari S,Wang R,Campbell S,Mosure SA,Chopp LB,Lu Q,Shang J,Pelletier OB,He Y,Doebelin C,Cameron MD,Kojetin DJ,Kamenecka TM,Solt LA

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Dec 26 00:00:00 EST 2018

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype.

Nature communications

Chen D,Xie J,Fiskesund R,Dong W,Liang X,Lv J,Jin X,Liu J,Mo S,Zhang T,Cheng F,Zhou Y,Zhang H,Tang K,Ma J,Liu Y,Huang B

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Feb 28 00:00:00 EST 2018

Lymphotoxin α fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells.

Nature communications

Lopes N,Charaix J,Cédile O,Sergé A,Irla M

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Mar 28 00:00:00 EDT 2018

IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells.

Nature communications

Hsieh WC,Hsu TS,Chang YJ,Lai MZ

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Jan 31 00:00:00 EST 2018

Neuregulin-1 elicits a regulatory immune response following traumatic spinal cord injury.

Journal of neuroinflammation

Alizadeh A,Santhosh KT,Kataria H,Gounni AS,Karimi-Abdolrezaee S

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Feb 21 00:00:00 EST 2018

High dietary salt intake correlates with modulated Th17-Treg cell balance resulting in enhanced bone loss and impaired bone-microarchitecture in male mice.

Scientific reports

Dar HY,Singh A,Shukla P,Anupam R,Mondal RK,Mishra PK,Srivastava RK

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Feb 06 00:00:00 EST 2018

Limited Foxp3⁺ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8⁺ T Cell Immunity.

Frontiers in immunology

Araujo Furlan CL,Tosello Boari J,Rodriguez C,Canale FP,Fiocca Vernengo F,Boccardo S,Beccaria CG,Adoue V,Joffre O,Gruppi A,Montes CL,Acosta Rodriguez EV

45-5773 was used in Flow cytometry/Cell sorting to study the role of regulatory T cells during Trypanosoma cruzi infection.

Thu Sep 26 00:00:00 EDT 2019

An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.

Cancer cell

Palazon A,Tyrakis PA,Macias D,Veliça P,Rundqvist H,Fitzpatrick S,Vojnovic N,Phan AT,Loman N,Hedenfalk I,Hatschek T,Lövrot J,Foukakis T,Goldrath AW,Bergh J,Johnson RS

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Nov 13 00:00:00 EST 2017

Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.

Cell host & microbe

Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Apr 12 00:00:00 EDT 2017

Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment.

The Journal of clinical investigation

Wang YT,Chen J,Chang CW,Jen J,Huang TY,Chen CM,Shen R,Liang SY,Cheng IC,Yang SC,Lai WW,Cheng KH,Hsieh TS,Lai MZ,Cheng HC,Wang YC,Chen RH

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.

The Journal of clinical investigation

Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.

The Journal of clinical investigation

Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

PTEN drives Th17 cell differentiation by preventing IL-2 production.

The Journal of experimental medicine

Kim HS,Jang SW,Lee W,Kim K,Sohn H,Hwang SS,Lee GR

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Nov 06 00:00:00 EST 2017

IL-2 prevents deletion of developing T-regulatory cells in the thymus.

Cell death and differentiation

Hu DY,Wirasinha RC,Goodnow CC,Daley SR

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Jun 01 00:00:00 EDT 2017

A bidirectional association between the gut microbiota and CNS disease in a biphasic murine model of multiple sclerosis.

Gut microbes

Colpitts SL,Kasper EJ,Keever A,Liljenberg C,Kirby T,Magori K,Kasper LH,Ochoa-Repáraz J

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Nov 02 00:00:00 EDT 2017

The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice.

Journal of immunology (Baltimore, Md. : 1950)

Sitrin J,Suto E,Wuster A,Eastham-Anderson J,Kim JM,Austin CD,Lee WP,Behrens TW

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Aug 15 00:00:00 EDT 2017

Dichloroacetate induces regulatory T-cell differentiation and suppresses Th17-cell differentiation by pyruvate dehydrogenase kinase-independent mechanism.

The Journal of pharmacy and pharmacology

Makita N,Ishiguro J,Suzuki K,Nara F

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2017

Growth Arrest-Specific 6 Enhances the Suppressive Function of CD4⁺CD25⁺ Regulatory T Cells Mainly through Axl Receptor.

Mediators of inflammation

Zhao GJ,Zheng JY,Bian JL,Chen LW,Dong N,Yu Y,Hong GL,Chandoo A,Yao YM,Lu ZQ

45-5773 was used in Flow cytometry/Cell sorting to investigate the role of the TAM ligand, growth arrest-specific 6, as an immune modulator.

Mon Jul 10 00:00:00 EDT 2017

SH479, a Betulinic Acid Derivative, Ameliorates Experimental Autoimmune Encephalomyelitis by Regulating the T Helper 17/Regulatory T Cell Balance.

Molecular pharmacology

Li J,Jing J,Bai Y,Li Z,Xing R,Tan B,Ma X,Qiu WW,Du C,Du B,Yang F,Tang J,Siwko S,Liu M,Chen H,Luo J

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

Placenta‑derived mesenchymal stem cells improve airway hyperresponsiveness and inflammation in asthmatic rats by modulating the Th17/Treg balance.

Molecular medicine reports

Li Y,Li H,Cao Y,Wu F,Ma W,Wang Y,Sun S

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Dec 01 00:00:00 EST 2017

Adipose-derived mesenchymal stem cells suppress of acute rejection in small bowel transplantation.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association

Zhang Y,Meng Q,Zhang Y,Chen X,Wang Y

45-5773 was used in Flow cytometry/Cell sorting to demonstrate that adipose-derived mesenchymal stem cells improve allogeneic small bowel allograft outcomes by attenuating acute rejection and reducing inflammatory responses.

Mon Nov 05 00:00:00 EST 2018

B cells inhibit the antitumor immunity against an established murine fibrosarcoma.

Oncology letters

Maglioco A,Machuca DG,Badano MN,Nannini P,Camerano GV,Costa H,Meiss R,Ruggiero RA,Giordano M,Dran GI

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

Enhancement of antitumor immunity by combination of anti-CTLA-4 antibody and radioimmunotherapy through the suppression of Tregs.

Oncology letters

Son CH,Bae J,Lee HR,Yang K,Park YS

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon May 01 00:00:00 EDT 2017

Immunological effects of vaccines combined with granulocyte colony-stimulating factor on a murine WEHI-3 leukemia model.

Oncology letters

Chen J,Zhang M,Zhou F,Wang J,Niu B,Zhang W

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

Proteomic changes of CD4⁺/CD25⁺/forkhead box p3⁺ regulatory T cells in a 30-day rat model of sepsis survival.

Experimental and therapeutic medicine

Jiao Y,Tan S,Xiong J

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Dec 01 00:00:00 EST 2017

Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APP_SWE/PS1_ΔE9 murine model of Alzheimer's disease.

Scientific reports

Minter MR,Hinterleitner R,Meisel M,Zhang C,Leone V,Zhang X,Oyler-Castrillo P,Zhang X,Musch MW,Shen X,Jabri B,Chang EB,Tanzi RE,Sisodia SS

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Sep 05 00:00:00 EDT 2017

Batf3-dependent CD8α⁺ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.

EBioMedicine

Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.

Scientific reports

Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Feb 06 00:00:00 EST 2017

Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy.

Nature communications

Liu Z,Ravindranathan R,Kalinski P,Guo ZS,Bartlett DL

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Mar 27 00:00:00 EDT 2017

MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis.

Stem cell reports

Shigemoto-Kuroda T,Oh JY,Kim DK,Jeong HJ,Park SY,Lee HJ,Park JW,Kim TW,An SY,Prockop DJ,Lee RH

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue May 09 00:00:00 EDT 2017

The effects of freeze-dried Ganoderma lucidum mycelia on a recurrent oral ulceration rat model.

BMC complementary and alternative medicine

Xie L,Zhong X,Liu D,Liu L,Xia Z

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Dec 01 00:00:00 EST 2017

Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.

Oncoimmunology

Huang RY,Francois A,McGray AR,Miliotto A,Odunsi K

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis.

PloS one

Komegae EN,Souza TA,Grund LZ,Lima C,Lopes-Ferreira M

45577382 was used in flow cytometry to study the therapeutic TnP peptide in inflammation and demyelination in a mouse model of multiple sclerosis.

Thu Aug 17 00:00:00 EDT 2017

Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.

The Journal of biological chemistry

Hayakawa M,Hayakawa H,Petrova T,Ritprajak P,Sutavani RV,Jiménez-Andrade GY,Sano Y,Choo MK,Seavitt J,Venigalla RKC,Otsu K,Georgopoulos K,Arthur JSC,Park JM

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Feb 03 00:00:00 EST 2017

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.

Nature communications

Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Feb 13 00:00:00 EST 2017

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.

Cell

Clever D,Roychoudhuri R,Constantinides MG,Askenase MH,Sukumar M,Klebanoff CA,Eil RL,Hickman HD,Yu Z,Pan JH,Palmer DC,Phan AT,Goulding J,Gattinoni L,Goldrath AW,Belkaid Y,Restifo NP

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Aug 25 00:00:00 EDT 2016

Lymphatic vessels regulate immune microenvironments in human and murine melanoma.

The Journal of clinical investigation

Lund AW,Wagner M,Fankhauser M,Steinskog ES,Broggi MA,Spranger S,Gajewski TF,Alitalo K,Eikesdal HP,Wiig H,Swartz MA

45-5773 was used in Flow cytometry/Cell sorting to suggest that the establishment of tumour-associated inflammation and immunity critically depends on lymphatic vessel remodelling and drainage.

Thu Sep 01 00:00:00 EDT 2016

B-cell anergy induces a Th17 shift in a novel B lymphocyte transgenic NOD mouse model, the 116C-NOD mouse.

European journal of immunology

Carrascal J,Carrillo J,Arpa B,Egia-Mendikute L,Rosell-Mases E,Pujol-Autonell I,Planas R,Mora C,Mauricio D,Ampudia RM,Vives-Pi M,Verdaguer J

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Mar 01 00:00:00 EST 2016

Natural genetic variation profoundly regulates gene expression in immune cells and dictates susceptibility to CNS autoimmunity.

Genes and immunity

Bearoff F,Del Rio R,Case LK,Dragon JA,Nguyen-Vu T,Lin CY,Blankenhorn EP,Teuscher C,Krementsov DN

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2016

Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.

Molecular medicine reports

Gu L,Deng WS,Sun XF,Zhou H,Xu Q

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model.

Molecular medicine reports

Yue Y,Li P,Song N,Li B,Li Z,Guo Y,Zhang W,Wei MQ,Gai Z,Meng H,Wang J,Qin L

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Sun May 01 00:00:00 EDT 2016

Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice.

Autoimmunity

Haddad CS,Bhattacharya P,Alharshawi K,Marinelarena A,Kumar P,El-Sayed O,Elshabrawy HA,Epstein AL,Prabhakar BS

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin.

Veterinary immunology and immunopathology

Wang Z,Navarro-Alvarez N,Shah JA,Zhang H,Huang Q,Zheng Q,Madsen JC,Sachs DH,Huang CA,Wang Z

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2016

Kappa opioid receptor activation alleviates experimental autoimmune encephalomyelitis and promotes oligodendrocyte-mediated remyelination.

Nature communications

Du C,Duan Y,Wei W,Cai Y,Chai H,Lv J,Du X,Zhu J,Xie X

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Apr 04 00:00:00 EDT 2016

Protection from experimental autoimmune encephalomyelitis by polyclonal IgG requires adjuvant-induced inflammation.

Journal of neuroinflammation

Quast I,Keller CW,Weber P,Schneider C,von Gunten S,Lünemann JD

45-5773 was used in Flow cytometry/Cell sorting to identify factors affecting the efficacy of intravenous immunoglobulin treatment for multiple sclerosis.

Thu Feb 18 00:00:00 EST 2016

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.

Nature communications

Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Wed Jun 08 00:00:00 EDT 2016

Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis.

JCI insight

Federico G,Meister M,Mathow D,Heine GH,Moldenhauer G,Popovic ZV,Nordström V,Kopp-Schneider A,Hielscher T,Nelson PJ,Schaefer F,Porubsky S,Fliser D,Arnold B,Gröne HJ

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Jan 21 00:00:00 EST 2016

Vitamin D3 improves the effects of low dose Der p 2 allergoid treatment in Der p 2 sensitized BALB/c mice.

Clinical and molecular allergy : CMA

Petrarca C,Clemente E,Amato V,Gatta A,Cortese S,Lamolinara A,Rossi C,Zanotta S,Mistrello G,Paganelli R,Di Gioacchino M

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Aug 08 00:00:00 EDT 2016

Viral Infection of the Central Nervous System Exacerbates Interleukin-10 Receptor Deficiency-Mediated Colitis in SJL Mice.

PloS one

Uhde AK,Herder V,Akram Khan M,Ciurkiewicz M,Schaudien D,Teich R,Floess S,Baumgärtner W,Huehn J,Beineke A

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Aug 25 00:00:00 EDT 2017

Induced Treg Cells Augment the Th17-Mediated Intestinal Inflammatory Response in a CTLA4-Dependent Manner.

PloS one

Watanabe N,Kaminuma O,Kitamura N,Hiroi T

45-5773 was used in Flow cytometry/Cell sorting to study whether Th17 and Tregs that promote and suppress inflammatory responses, respectively, work with or against each other in immune reactions, showing that cotransfer of Th17 and induced Tregs led to increased inflammation, and blockage of CTLA4 led to abrogation of this effect.

Mon Aug 01 00:00:00 EDT 2016

Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy.

Nature communications

Shi LZ,Fu T,Guan B,Chen J,Blando JM,Allison JP,Xiong L,Subudhi SK,Gao J,Sharma P

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Aug 08 00:00:00 EDT 2016

Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination.

Scientific reports

Stifter K,Schuster C,Schlosser M,Boehm BO,Schirmbeck R

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Jul 11 00:00:00 EDT 2016

MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health.

Cell host & microbe

Kubinak JL,Petersen C,Stephens WZ,Soto R,Bake E,O'Connell RM,Round JL

45-5773 was used in Flow cytometry/Cell sorting to show that signalling through the innate adaptor MyD88 in gut T cells coordinates germinal center responses, including T follicular helper cell and IgA+ B cell development.

Wed Feb 11 00:00:00 EST 2015

FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3.

The Journal of clinical investigation

Wang L,Liu Y,Han R,Beier UH,Bhatti TR,Akimova T,Greene MI,Hiebert SW,Hancock WW

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Mar 02 00:00:00 EST 2015

Towards programming immune tolerance through geometric manipulation of phosphatidylserine.

Biomaterials

Roberts RA,Eitas TK,Byrne JD,Johnson BM,Short PJ,McKinnon KP,Reisdorf S,Luft JC,DeSimone JM,Ting JP

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2015

MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.

Proceedings of the National Academy of Sciences of the United States of America

Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Dec 29 00:00:00 EST 2015

Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance.

International journal of obesity (2005)

Khan IM,Perrard XY,Brunner G,Lui H,Sparks LM,Smith SR,Wang X,Shi ZZ,Lewis DE,Wu H,Ballantyne CM

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Sun Nov 01 00:00:00 EDT 2015

Leptin receptor signaling in T cells is required for Th17 differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Reis BS,Lee K,Fanok MH,Mascaraque C,Amoury M,Cohn LB,Rogoz A,Dallner OS,Moraes-Vieira PM,Domingos AI,Mucida D

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2015

Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology.

Nature communications

Baruch K,Rosenzweig N,Kertser A,Deczkowska A,Sharif AM,Spinrad A,Tsitsou-Kampeli A,Sarel A,Cahalon L,Schwartz M

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Aug 18 00:00:00 EDT 2015

Vesicular stomatitis virus expressing interferon-β is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer.

Oncotarget

Patel MR,Jacobson BA,Ji Y,Drees J,Tang S,Xiong K,Wang H,Prigge JE,Dash AS,Kratzke AK,Mesev E,Etchison R,Federspiel MJ,Russell SJ,Kratzke RA

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Oct 20 00:00:00 EDT 2015

Promotion of regulatory T cell induction by immunomodulatory herbal medicine licorice and its two constituents.

Scientific reports

Guo A,He D,Xu HB,Geng CA,Zhao J

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Sep 15 00:00:00 EDT 2015

Bi-Allelic TCRα or β Recombination Enhances T Cell Development but Is Dispensable for Antigen Responses and Experimental Autoimmune Encephalomyelitis.

PloS one

Schuldt NJ,Auger JL,Hogquist KA,Binstadt BA

45-5773 was used in Flow cytometry/Cell sorting to investigate dual TCRβ expression in T cells.

Thu Jun 23 00:00:00 EDT 2016

Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.

Nature communications

Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Sep 29 00:00:00 EDT 2015

MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres.

Nature communications

Pratama A,Srivastava M,Williams NJ,Papa I,Lee SK,Dinh XT,Hutloff A,Jordan MA,Zhao JL,Casellas R,Athanasopoulos V,Vinuesa CG

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Mar 06 00:00:00 EST 2015

Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression.

Cancer cell

Xu C,Fillmore CM,Koyama S,Wu H,Zhao Y,Chen Z,Herter-Sprie GS,Akbay EA,Tchaicha JH,Altabef A,Reibel JB,Walton Z,Ji H,Watanabe H,Jänne PA,Castrillon DH,Rustgi AK,Bass AJ,Freeman GJ,Padera RF,Dranoff G,Hammerman PS,Kim CF,Wong KK

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon May 12 00:00:00 EDT 2014

The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.

Nature immunology

Nagashima H,Okuyama Y,Asao A,Kawabe T,Yamaki S,Nakano H,Croft M,Ishii N,So T

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity.

Annals of neurology

Breuer J,Schwab N,Schneider-Hohendorf T,Marziniak M,Mohan H,Bhatia U,Gross CC,Clausen BE,Weishaupt C,Luger TA,Meuth SG,Loser K,Wiendl H

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Tryptophan catabolism restricts IFN-γ-expressing neutrophils and Clostridium difficile immunopathology.

Journal of immunology (Baltimore, Md. : 1950)

El-Zaatari M,Chang YM,Zhang M,Franz M,Shreiner A,McDermott AJ,van der Sluijs KF,Lutter R,Grasberger H,Kamada N,Young VB,Huffnagle GB,Kao JY

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Jul 15 00:00:00 EDT 2014

Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.

Human vaccines & immunotherapeutics

Wang S,Wu B,Xue J,Wang M,Chen R,Wang B

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Jan 05 00:00:00 EST 2015

High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.

Nature immunology

Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2013

IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.

Nature immunology

Mascanfroni ID,Yeste A,Vieira SM,Burns EJ,Patel B,Sloma I,Wu Y,Mayo L,Ben-Hamo R,Efroni S,Kuchroo VK,Robson SC,Quintana FJ

45-5773 was used in Flow cytometry/Cell sorting to assess the regulation of T cells by dendritic cells.

Tue Oct 01 00:00:00 EDT 2013

Diesel exhaust particle induction of IL-17A contributes to severe asthma.

The Journal of allergy and clinical immunology

Brandt EB,Kovacic MB,Lee GB,Gibson AM,Acciani TH,Le Cras TD,Ryan PH,Budelsky AL,Khurana Hershey GK

45-5773 was used in Flow cytometry/Cell sorting to determine the mechanism by which diesel exhaust particles affect asthma severity, showing that diesel exhaust particles increase airway responsiveness to house dust mite extract due to increased levels of IL-17A, suggesting neutralisation of IL-17A could be used as a future therapy.

Fri Nov 01 00:00:00 EDT 2013

Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.

Cardiovascular research

Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2013

PLG scaffold delivered antigen-specific regulatory T cells induce systemic tolerance in autoimmune diabetes.

Tissue engineering. Part A

Graham JG,Zhang X,Goodman A,Pothoven K,Houlihan J,Wang S,Gower RM,Luo X,Shea LD

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Sat Jun 01 00:00:00 EDT 2013

Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.

PloS one

Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Thu Jul 31 00:00:00 EDT 2014

Regulatory T cells are protective in systemic inflammation response syndrome induced by zymosan in mice.

PloS one

Jia W,Cao L,Yang S,Dong H,Zhang Y,Wei H,Jing W,Hou L,Wang C

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Dec 17 00:00:00 EST 2013

Artemisinin analogue SM934 ameliorates murine experimental autoimmune encephalomyelitis through enhancing the expansion and functions of regulatory T cell.

PloS one

Li X,Li TT,Zhang XH,Hou LF,Yang XQ,Zhu FH,Tang W,Zuo JP

45-5773 was used in Flow cytometry/Cell sorting to explore the effects of SM934 on Th1, Th17 and Treg cell differentiation.

Wed Apr 16 00:00:00 EDT 2014

Regulatory T cells that recognize a ubiquitous stress-inducible self-antigen are long-lived suppressors of autoimmune arthritis.

Proceedings of the National Academy of Sciences of the United States of America

van Herwijnen MJ,Wieten L,van der Zee R,van Kooten PJ,Wagenaar-Hilbers JP,Hoek A,den Braber I,Anderton SM,Singh M,Meiring HD,van Els CA,van Eden W,Broere F

45-5773 was used in Flow cytometry/Cell sorting to uncover potent disease-suppressive Treg cells that recognise Hsp 70, with the potential for re-establishing self-tolerance in autoimmunity.

Tue Aug 28 00:00:00 EDT 2012

Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Mineharu Y,Muhammad AK,Yagiz K,Candolfi M,Kroeger KM,Xiong W,Puntel M,Liu C,Levy E,Lugo C,Kocharian A,Allison JP,Curran MA,Lowenstein PR,Castro MG

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Mon Oct 01 00:00:00 EDT 2012

Role of donor-specific regulatory T cells in long-term acceptance of rat hind limb allograft.

PloS one

Wang Y,Zheng Z,Wang Y,Liu J,Li N,Hu X,Han F,Liu Y,Hu D

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Feb 19 00:00:00 EST 2013

CD4(+) CD25(+) FoxP3(+) regulatory T cells suppress cytotoxicity of CD8(+) effector T cells: implications for their capacity to limit inflammatory central nervous system damage at the parenchymal level.

Journal of neuroinflammation

Göbel K,Bittner S,Melzer N,Pankratz S,Dreykluft A,Schuhmann MK,Meuth SG,Wiendl H

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Feb 28 00:00:00 EST 2012

MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.

Journal of immunology (Baltimore, Md. : 1950)

McPhee CG,Sproule TJ,Shin DM,Bubier JA,Schott WH,Steinbuck MP,Avenesyan L,Morse HC,Roopenian DC

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Tue Nov 01 00:00:00 EDT 2011

Sensitive detection of Foxp3 expression in bovine lymphocytes by flow cytometry.

Veterinary immunology and immunopathology

Gerner W,Stadler M,Hammer SE,Klein D,Saalmüller A

Mon Nov 15 00:00:00 EST 2010

Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells.

Self/nonself

Capurso NA,Look M,Jeanbart L,Nowyhed H,Abraham C,Craft J,Fahmy TM

Published figure using FOXP3 monoclonal antibody (Product # 45-5773-82) in Flow Cytometry

Fri Oct 01 00:00:00 EDT 2010

Bioinformatics

Protein Aliases: Forkhead box protein P3; forkhead/winged helix transcription factor 3; Foxp3; MGC141961; MGC141963; RP23-54C14.1; Scurfin; scurfy

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Gene Aliases: Foxp3; JM2; RGD1562112; scurfin; sf

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UniProt ID: (Mouse) Q99JB6

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Entrez Gene ID: (Dog) 491876, (Pig) 444998, (Bovine) 506053, (Cat) 100037405, (Mouse) 20371, (Rat) 317382

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Function(s)

core promoter binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription corepressor activity protein binding histone acetyltransferase binding protein homodimerization activity histone deacetylase binding sequence-specific DNA binding metal ion binding NFAT protein binding RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function

Process(es)

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FOXP3 Monoclonal Antibody (FJK-16s), PerCP-Cyanine5.5, eBioscience™

FOXP3 Antibody (45-5773-82) in Flow

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45-5773-82

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